ライフサイエンスコーパス: sphingosine-1-phosphate receptor

1 adenosine receptors, dopamine receptor, and sphingosine 1-phosphate receptor.

2 contrasting with the proposed access for the sphingosine 1-phosphate receptor.

3 from chemokine receptors, integrins, and the sphingosine-1-phosphate receptor.

4 of activation-induced cytidine deaminase and sphingosine-1-phosphate receptor.

5 s such as vasa, pumilio and piwi, as well as sphingosine-1-phosphate receptor.

6 d maturation by activating G protein-coupled sphingosine 1-phosphate receptors.

7 d apoptosis was independent of activation of sphingosine 1-phosphate receptors.

8 n and mouse S1P(5) gene products as encoding sphingosine 1-phosphate receptors.

9 signals mediated by chemokine, integrin, and sphingosine-1-phosphate receptors.

10 er cell apoptosis in a manner independent of sphingosine-1-phosphate receptors.

11 extramedullary tissues into lymph depends on sphingosine-1-phosphate receptors.

12 ndent "transactivation" of G protein-coupled sphingosine-1-phosphate receptors.

13 homodimers: the CXC chemokine receptor 4 and sphingosine-1-phosphate receptors.

14 ation of surface-expressed G protein-coupled sphingosine-1-phosphate receptors.

15 to optimize the oral exposure of a series of sphingosine 1-phosphate receptor 1 (S1P(1)) antagonists

16 A series of subtype selective sphingosine 1-phosphate receptor 1 (S1P(1)) antagonists

17 Sphingosine 1-phosphate receptor 1 (S1P(1)) is a G prote

18 The sphingosine 1-phosphate receptor 1 (S1P(1)) promotes lym

19 Activation of the sphingosine 1-phosphate receptor 1 (S1P(1)R) protects ag

20 Sphingosine 1-phosphate receptor 1 (S1P1) plays a pivota

21 Sphingosine 1-phosphate receptor 1 (S1P1), a G protein-c

22 Whereas the role of sphingosine 1-phosphate receptor 1 (S1PR1) in T cell egr

23 4 protect hypoxia-induced BBB disruption via Sphingosine 1-phosphate receptor 1 (S1PR1) modulation.

24 targets, including the key migratory factor sphingosine 1-phosphate receptor 1 (S1PR1).

25 Endothelial cells were stimulated with sphingosine 1-phosphate receptor 1 agonists to determine

26 th sphingosine 1-phosphate, FTY720, or other sphingosine 1-phosphate receptor 1 agonists.

27 L/6 mice with bleomycin to assess effects of sphingosine 1-phosphate receptor 1 agonists.

28 ves a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-

29 red mice maintains significantly higher lung sphingosine 1-phosphate receptor 1 expression compared w

30 receptor 1 agonists to determine effects on sphingosine 1-phosphate receptor 1 expression.

31 ere, we present the crystal structure of the sphingosine 1-phosphate receptor 1 fused to T4-lysozyme

32 ave important implications for targeting the sphingosine 1-phosphate receptor 1 in solid organ transp

33 Agonism of sphingosine 1-phosphate receptor 1 inhibited the entry o

34 r-promoting agent that effectively maintains sphingosine 1-phosphate receptor 1 levels and improves o

35 The selective sphingosine 1-phosphate receptor 1 modulator RP101075 im

36 Synthetic sphingosine 1-phosphate receptor 1 modulators constitute

37 FTY720 (S)-phosphonate maintains endothelial sphingosine 1-phosphate receptor 1 protein expression in

38 FTY720 is a high-affinity agonist at the sphingosine 1-phosphate receptor 1 that prevents lymphoc

39 e does not induce beta-arrestin recruitment, sphingosine 1-phosphate receptor 1 ubiquitination, and p

40 Reduction of sphingosine 1-phosphate receptor 1 with small interferen

41 ed these observations to confirm that S1PR1 (sphingosine 1-phosphate receptor 1) and integrin beta4 (

42 he cell surface and consequent activation of sphingosine 1-phosphate receptor 1, Src and Fyn tyrosine

43 pathway, and a downstream target of KLF2 is sphingosine 1-phosphate receptor 1.

44 experiments to determine whether ASP4058, a sphingosine 1-phosphate receptor 1/5 (S1P1/5) agonist, i

45 Sphingosine-1 phosphate receptor 1 (S1P1) is critical fo

46 controlling cell-movement regulators such as sphingosine-1 phosphate receptor 1 (S1PR1).

47 CD62L and beta7-integrin, yet expression of sphingosine-1 phosphate receptor 1 (which is a critical

48 The sphingosine-1-phosphate receptor 1 (S1P(1)) is expressed

49 Sphingosine-1-phosphate receptor 1 (S1P(1)) was recently

50 g a newly characterized potent and selective sphingosine-1-phosphate receptor 1 (S1P) agonist with ph

51 Activation of the GPCR sphingosine-1-phosphate receptor 1 (S1P1) by sphingosine

52 nic lymphocyte accumulation involved reduced sphingosine-1-phosphate receptor 1 (S1P1) expression and

53 Furthermore, deletion of the sphingosine-1-phosphate receptor 1 (S1P1) in these precu

54 und that iNKT cells are divided into CD69(+) sphingosine-1-phosphate receptor 1 (S1P1)(-) tissue resi

55 ly activates the promoters of both CD62L and sphingosine-1-phosphate receptor 1 (S1P1), whose express

56 by utilizing the clinically important GPCR, sphingosine-1-phosphate receptor 1 (S1P1).

57 phingosine-related therapeutics, agonists of sphingosine-1-phosphate receptor 1 (S1P1).

58 pability and increased surface expression of sphingosine-1-phosphate receptor 1 (S1P1).

59 The sphingosine-1-phosphate receptor 1 (S1PR1) and beta1-adr

60 or lung migration, they failed to upregulate sphingosine-1-phosphate receptor 1 (S1PR1) and its criti

61 The activation of Sphingosine-1-phosphate receptor 1 (S1PR1) by S1P promot

62 agonist-induced internalisation of the GPCR sphingosine-1-phosphate receptor 1 (S1PR1) in these cell

63 Sphingosine-1-phosphate receptor 1 (S1PR1) is recognized

64 evant dose of FTY720/Fingolimod that targets sphingosine-1-phosphate receptor 1 (S1PR1), alleviated p

65 ASM stems from impaired signaling downstream sphingosine-1-phosphate receptor 1 (S1PR1), which normal

66 itical to this pathway was signaling through sphingosine-1-phosphate receptor 1 (S1PR1).

67 ate of GPCRs, exemplified by ER retention of sphingosine-1-phosphate receptor 1 (S1PR1).

68 of thymus-exiting and skin-homing molecules sphingosine-1-phosphate receptor 1 and CCR10 and accumul

69 Lymphocyte sequestration with sphingosine-1-phosphate receptor 1 antagonist FTY720 spe

70 Accordingly, FTY720, a sphingosine-1-phosphate receptor 1 antagonist, failed to

71 Teijaro et al. now demonstrate that sphingosine-1-phosphate receptor 1 ligands suppress all

72 novel immunomodulator FTY720 down-modulates sphingosine-1-phosphate receptor 1 on lymphocytes at low

73 r Rac1 and Rac2 in transducing chemokine and sphingosine-1-phosphate receptor 1 signals leading to mo

74 S1P1 (sphingosine-1-phosphate receptor 1) agonists prevent lym

75 and tissue retention markers but diminished sphingosine-1-phosphate receptor 1, a receptor that faci

76 Ana is known to act upon the sphingosine-1-phosphate receptor 1, and we determined th

77 nanomolar concentrations, thereby inhibiting sphingosine-1-phosphate receptor 1-dependent egress of l

78 his microRNA, including heme oxygenase-1 and sphingosine-1-phosphate receptor 1.

79 lipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.

80 enitor cells (NSCs) in vitro via a PAR1-PAR3-sphingosine-1-phosphate-receptor 1-Akt pathway, which su

81 lation of CC-chemokine receptor 7 (CCR7) and sphingosine 1- phosphate receptor-1 (S1PR1) expression a

82 m lymph nodes requires the G-protein-coupled sphingosine 1-phosphate receptor-1 (S1P(1)).

83 Lymphocyte egress requires sphingosine 1-phosphate receptor-1 (S1P1), and IFN-alpha

84 the beta2 adrenergic receptor (beta2AR), the sphingosine 1-phosphate receptor-1 (S1P1), or the kappa-

85 ed growth factor (PDGF)beta receptor and the sphingosine 1-phosphate receptor-1 (S1P1).

86 Here, we show that the deletion of the GPCR sphingosine 1-phosphate receptor-1 (S1PR1) from lymphati

87 gle-cell) and chromatin domains regulated by sphingosine 1-phosphate receptor-1 (S1PR1) in adult mous

88 Sphingosine 1-phosphate receptor-1 (S1PR1) in endothelia

89 Sphingosine 1-phosphate receptor-1 (S1PR1) is essential

90 We showed that sphingosine 1-phosphate receptor-1 agonist FTY720 induce

91 SEW2871, a sphingosine 1-phosphate receptor-1 agonist that activate

92 An established role of sphingosine 1-phosphate receptor-1 in T cells is to guid

93 lial sphingosine 1-phosphate signals through sphingosine 1-phosphate receptor-1 to prevent mitochondr

94 Sphingosine-1 phosphate receptor-1 (S1P(1)) plays fundam

95 use they down-regulate the expression of the sphingosine-1 phosphate receptor-1, which mediates the e

96 was required for effective transcription of sphingosine-1-phosphate receptor-1 (S1P(1)) and CD62L in

97 have identified cortical sinuses as sites of sphingosine-1-phosphate receptor-1 (S1P(1))-dependent T-

98 The mechanism by which sphingosine-1-phosphate receptor-1 (S1P1) acts to promot

99 We have shown that transgenic expression of sphingosine-1-phosphate receptor-1 (S1P1) in immature th

100 repressor Gfi1, which induces expression of sphingosine-1-phosphate receptor-1 (S1P1) on negatively

101 The expression of sphingosine-1-phosphate receptor-1 (S1PR1) and sphingosi

102 ible mouse model with a temporally disrupted sphingosine-1-phosphate receptor-1 (S1PR1) gene specific

103 We show that expression of sphingosine-1-phosphate receptor-1 (S1PR1), a G protein-

104 B-arr2-mediated sphingosine kinase-1 (SphK1)-sphingosine-1-phosphate receptor-1 (S1PR1)-Akt signaling

105 cular B-cell egress via the marginal zone is sphingosine-1-phosphate receptor-1 (S1PR1)-dependent.

106 clear receptor RORc and an antagonist of the sphingosine-1-phosphate receptor-1-via late-stage methyl

107 the sphingosine kinase-1 inhibitor, and the sphingosine-1-phosphate receptor-1/-3 antagonist VPC2301

108 inhibit PP2A and that FTY720-P, acting as a sphingosine-1-phosphate-receptor-1 agonist, elicits sign

109 amily (expressed in HEK293 cells) identified sphingosine-1-phosphate receptor 2 (S1P(2) ) as being ac

110 Here, we find that sphingosine-1-phosphate receptor 2 (S1PR2) acts in a cel

111 neutralizing anti-S1P antibody (mAb) and the sphingosine-1-phosphate receptor 2 (S1PR2) antagonist JT

112 Additionally, we identified sphingosine-1-phosphate receptor 2 (S1PR2) as a novel in

113 We identified sphingosine-1-phosphate receptor 2 (S1PR2) as a sex- and

114 re we showed that reducing the expression of sphingosine-1-phosphate receptor 2 (S1PR2) in mice liver

115 We find that the sphingosine-1-phosphate receptor 2 (S1PR2) is repressed

116 bition of the G-protein-coupled BA receptor, sphingosine-1-phosphate receptor 2 (S1PR2), by JTE-013,

117 Moreover, we identified a BA receptor, sphingosine-1-phosphate receptor 2 (S1PR2), required for

118 act via HSPGs independently of its receptor, Sphingosine-1-Phosphate receptor 2 (S1PR2).

119 Work in mice showed that sphingosine-1-phosphate receptor-2 (S1PR2), a Galpha12 a

120 uencing revealed a Thr289Arg substitution in Sphingosine-1-Phosphate Receptor-2 (S1pr2).

121 ere more resistant but became dispersed when sphingosine-1-phosphate receptor-2 was also removed.

122 in the aPC pathway were fully compensated by sphingosine 1 phosphate receptor 3 (S1P3) deficiency or

123 We demonstrate here that local sphingosine 1-phosphate receptor 3 (S1P3) agonism recrui

124 Previously, we showed that levels of sphingosine-1 phosphate receptor 3 (S1PR3) are increased

125 In contrast, genetic deletion of sphingosine-1-phosphate receptor 3 (S1P3) and gp91phox/N

126 Here we investigate the role of sphingosine-1-phosphate receptor 3 (S1PR3) in regulating

127 Here we show that the sphingosine-1-phosphate receptor 3 (S1PR3) in the medial

128 We previously demonstrated that sphingosine-1-phosphate receptor 3 (S1PR3) in the medial

129 Notably, these cells express the sphingosine-1-phosphate receptor 3 (S1PR3), and stimulat

130 and this was attenuated by inhibition of the sphingosine-1-phosphate receptor 3 (S1PR3).

131 emokine receptors (CXCR1, CXCR2, and CXCR4), sphingosine 1-phosphate receptor-3 (S1P3), the melanocor

132 lls from lymph nodes in the mouse depends on sphingosine-1-phosphate receptor-3.

133 significantly upregulated the expression of sphingosine-1-phosphate receptor 4 on neutrophils, and t

134 Duane NK cells have a 30-fold deficiency in sphingosine-1-phosphate receptor 5 (S1P5) transcript lev

135 Sphingosine-1-phosphate receptor 5 (S1PR5) is a migrator

136 Sphingosine-1-phosphate receptor-5 (S1PR5) is highly exp

137 strongly support a cardioprotective role for sphingosine-1-phosphate receptor activation during MI.

138 We hypothesized that sphingosine-1-phosphate receptor activation with fingoli

139 Sphingosine-1-phosphate receptor activation with fingoli

140 treated with B cell-depleting (anti-CD20) or sphingosine 1-phosphate receptor agonist (fingolimod) th

141 Sphingosine 1-phosphate and the sphingosine 1-phosphate receptor agonist FTY720 did not

142 Notably, using a sphingosine 1-phosphate receptor agonist to sequester T

143 With this objective in mind, we used the sphingosine-1 phosphate receptor agonist fingolimod, a d

144 Since the new sphingosine-1-phosphate receptor agonist immunosuppressi

145 /HI administration of FTY720 (fingolimod), a sphingosine-1-phosphate receptor agonist that blocks lym

146 Mice lacking MZ B cells, or treated with a sphingosine-1-phosphate receptor agonist to dislocate th

147 eatment with sphingosine-1-phosphate or SEW (sphingosine-1-phosphate receptor agonist) remained effec

148 Fingolimod, a sphingosine-1-phosphate receptor agonist, is used for th

149 ral lymph nodes (LN) by direct activation of sphingosine 1-phosphate receptors, along with the partic

150 This pathway consists of cell-surface sphingosine-1-phosphate receptors, an intracellular casc

151 Recent studies have shown that sphingosine 1-phosphate receptors and their ligands are

152 We hypothesize that modulation of the sphingosine-1-phosphate receptor by FTY720 would be of t

153 We observe that CXC chemokine receptor 4 and sphingosine-1-phosphate receptors can form heterodimers

154 of goblet cell-associated antigen passages, sphingosine-1-phosphate receptor-dependent leukocyte tra

155 erized of a fourth, high affinity, rat brain sphingosine 1-phosphate receptor, Edg-8.

156 In mice deficient in sphingosine-1-phosphate receptor function, CB2 antagonis

157 that expression of CD69, by interfering with sphingosine-1-phosphate receptor function, is a critical

158 his comparative characterization of multiple sphingosine-1-phosphate receptor genes and their spatiot

159 Although modulation of sphingosine-1 phosphate receptors has proven beneficial

160 binoid CB(1) receptors and that it activates sphingosine-1-phosphate receptors in an enantiomer-speci

161 Nevertheless, the role of individual sphingosine-1-phosphate receptors in the regulation of a

162 nase inhibitor N, N-dimethylsphingosine or a sphingosine 1 phosphate receptor inhibitor VPC23019 on i

163 oring in patients with multiple sclerosis on sphingosine 1-phosphate receptor modulating agents.

164 Etrasimod (APD334) is an oral, selective sphingosine 1-phosphate receptor modulator in developmen

165 However, administration of FTY720, a sphingosine 1-phosphate receptor modulator that induces

166 Fingolimod, an oral sphingosine 1-phosphate receptor modulator, is effective

167 Ozanimod, a sphingosine 1-phosphate receptor modulator, selectively

168 Ozanimod is a sphingosine 1-phosphate receptor modulator, which select

169 we followed the hypothesis that siponimod, a sphingosine-1 phosphate receptor modulator, exerts prote

170 udy, fingolimod (FTY720), a lysophospholipid sphingosine-1-phosphate receptor modulator is administer

171 The sphingosine-1-phosphate receptor modulator, FTY720/fingo

172 Ozanimod, a selective sphingosine-1-phosphate receptor modulator, is under inv

173 Fingolimod (FTY720), a sphingosine-1-phosphate-receptor modulator that prevents

174 erferons, glatiramer acetate, teriflunomide, sphingosine 1-phosphate receptor modulators, fumarates,

175 atients receiving therapy with anti-CD20 and sphingosine-1 phosphate receptor modulators, antibody ti

176 n patients treated with anti-CD20 therapy or sphingosine-1 phosphate receptor modulators, the dynamic

177 yet robust comparative data on cladribine vs sphingosine-1-phosphate receptor modulators (S1PRMs) in

178 small molecules (Janus kinase inhibitors and sphingosine-1-phosphate receptor modulators).

179 or necrosis factor antagonists, vedolizumab, sphingosine-1-phosphate receptor modulators, interleukin

180 a specific anti-neurodegenerative effect of Sphingosine-1-phosphate-receptor modulators on astrocyte

181 onist or antagonist effects on select LPA or sphingosine 1-phosphate receptors, nor did they inhibit

182 matory sites by decreasing expression of the sphingosine-1 phosphate receptor normally required for e

183 IVIg or F(ab')2 fragments decrease the sphingosine-1 phosphate receptor on CD4 cells, thus sequ

184 After Tyro3 ligation, PS activated sphingosine 1-phosphate receptor (S1P(1)), resulting in

185 rapid recruitment (5 minutes) to CEMs of the sphingosine 1-phosphate receptor (S1P(1)), the serine/th

186 urn to the marginal zone was promoted by the sphingosine 1-phosphate receptors S1P1 and S1P3.

187 th the transcriptional downregulation of the sphingosine-1-phosphate receptor S1P1.

188 ed phosphorylation of, the barrier-promoting sphingosine 1-phosphate receptor (S1P1) within caveolin-

189 phate (S1P) is the endogenous ligand for the sphingosine 1-phosphate receptors (S1P1-5) and evokes a

190 Here, we show that the sphingosine 1-phosphate receptor (S1PR) modulator fingol

191 m, fingolimod-phosphate (fingolimod-P), is a sphingosine 1-phosphate receptor (S1PR) modulator that i

192 Sphingosine 1-phosphate receptor (S1PR)1 stimulation con

193 as 5-fold greater selectivity for binding to sphingosine-1-phosphate receptor (S1PR) 1 (S1PR(1)) vers

194 acid ((11)C-CS1P1), a radiotracer targeting sphingosine-1-phosphate receptor (S1PR) 1 (S1PR1).

195 cent data have demonstrated the potential of sphingosine-1-phosphate receptor (S1PR) agonism in the t

196 termine the impact of fingolimod (FTY720), a sphingosine-1-phosphate receptor (S1PR) agonist, on 2 mo

197 Sphingosine-1-phosphate receptor (S1PR) agonists have be

198 Agonists of the sphingosine-1-phosphate receptor (S1PR) attenuate kidney

199 Sphingosine-1-phosphate receptor (S1PR) modulators are c

200 Sphingosine-1-phosphate receptor (S1PR) modulators provi

201 New sphingosine-1-phosphate receptor (S1PR) modulators with

202 reating multiple sclerosis, is an agonist of sphingosine-1-phosphate receptor (S1PR), which has been

203 a IL-6-induced STAT3 activation but also via sphingosine-1-phosphate receptor (S1PR)-mediated IL-6 an

204 iated through S1P binding to specific GPCRs [sphingosine-1-phosphate receptor (S1PR)1-5] and some oth

205 thymus through transcriptional activation of sphingosine-1-phosphate receptor S1pr1 as well as for na

206 he adenosine A(2A) receptor (AA2AR), and the sphingosine 1-phosphate receptor (S1PR1).

207 Here, we show that retinal endothelial sphingosine 1-phosphate receptors (S1PRs), which restrai

208 The sphingosine-1-phosphate receptors (S1PRs) are a well-stu

209 Sphingosine-1-phosphate receptors (S1PRs) are potent reg

210 ific protease activated receptors (PARs) and sphingosine-1-phosphate receptors (S1PRs), in that siRNA

211 or potential vanilloid 1 (TRPV1) channel and sphingosine-1-phosphate receptors.SA1P also showed diffe

212 S1P(2) sphingosine 1-phosphate receptor signaling can regulate

213 The sphingosine 1-phosphate receptor-signaling pathway is be

214 These results indicate that FTY720- and sphingosine 1-phosphate receptor-stimulated T cell migra

215 in-mediated cell growth and survival via the sphingosine 1-phosphate receptor subtype 2 (S1P2) follow

216 in a straightforward total synthesis of the sphingosine 1-phosphate receptor-subtype 1 (S1P(1)) agon

217 ceptor modulator, which selectively binds to sphingosine 1-phosphate receptor subtypes 1 and 5 with h

218 Ozanimod (RPC1063) is an oral agonist of the sphingosine-1-phosphate receptor subtypes 1 and 5 that i

219 ta demonstrate that Edg-8 is a high affinity sphingosine 1-phosphate receptor that couples to G(i/o)a

220 The capacity of drugs that act on type 1 sphingosine 1-phosphate receptors to suppress organ graf

221 alphabeta T cells require sphingosine 1-phosphate receptor type 1 (S1P(1)) and CD6

222 T cells deficient in sphingosine 1-phosphate receptor type 1 probed the sinus

223 us probing is followed by entry dependent on sphingosine 1-phosphate receptor type 1, capture of cell

224 Mice deficient in sphingosine 1-phosphate receptor type 2 (S1P(2)) develop