ライフサイエンスコーパス: splicing factor

1 metabolism (RNA helicases, PRP19, p54(nrb), splicing factors).

2 a U1 small nuclear ribonucleoprotein (snRNP) splicing factor.

3 (TDP-43) is a transcriptional repressor and splicing factor.

4 e proper subnuclear storage of an SR protein splicing factor.

5 clear speckles, where it targets a cell mRNA splicing factor.

6 pre-mRNA splicing by lysine methylation of a splicing factor.

7 ed with the expression of DDX39A, encoding a splicing factor.

8 to each peak, including known and candidate splicing factors.

9 ng the RNA-binding preferences of individual splicing factors.

10 atively few genes and typically focus on RNA splicing factors.

11 gonism between CELF2 and the RBFOX family of splicing factors.

12 eme among MDS-relevant mutations of pre-mRNA splicing factors.

13 tion and is a frequent target of alternative splicing factors.

14 ts, and contribute to the timely eviction of splicing factors.

15 emodellers, microRNA-processing proteins and splicing factors.

16 odifications are balanced in these essential splicing factors.

17 y 'hotspots' of the SF3B1 and U2AF1 pre-mRNA splicing factors.

18 SR) proteins are essential nucleus-localized splicing factors.

19 difications and changes in the expression of splicing factors.

20 a ternary complex with U2AF(65) and U2AF(35) splicing factors.

21 ding of shuttling dynamics of Arabidopsis SR splicing factors.

22 ts UHM domain and ULM motifs in constitutive splicing factors.

23 , likely through modulating accessibility of splicing factors.

24 splicing program with sequence specific NOVA splicing factors.

25 proteins, thus functionally inactivating the splicing factors.

26 viral RNA cis elements and host trans-acting splicing factors.

27 HM domains from alternative and constitutive splicing factors.

28 spliceosomes in collaboration with numerous splicing factors.

29 er elements, as well as in genes that encode splicing factors.

30 i.e., protein-protein interactions with key splicing factors.

31 cularly in genes encoding RNA processing and splicing factors.

32 ed by both intronic repeats and trans-acting splicing factors.

33 s-sense mutations of genes encoding pre-mRNA splicing factors.

34 ations in splice regulatory sites or altered splicing factors.

35 rporated into condensates that are formed by splicing factors.

36 by other RNA-binding proteins, particularly splicing factors.

37 requires study of snRNAs, as well as protein splicing factors.

38 Splicing factor 1 (SF1) recognizes 3' splice sites of th

39 that are reduced by dietary restriction via splicing factor 1 (SFA-1; the C. elegans homologue of SF

40 Serine/arginine-rich splicing factor 1 (SRSF1) is an essential RNA-binding pr

41 ess a mutated allele of serine/arginine-rich splicing factor 2 (Srsf2(P95H))-which commonly occurs in

42 We identify the serine/arginine rich splicing factor 2 (SRSF2) as a novel VTRNA1.1-binding pr

43 Serine/arginine-rich splicing factor 2 (SRSF2) is an RNA-binding protein that

44 h high affinity to serine- and arginine-rich splicing factor 2 (SRSF2), a crucial protein in exon def

45 ntain binding sites for serine/arginine-rich splicing factor 2 (SRSF2), and SRSF2 knockdown lowered l

46 We recently described serine/arginine-rich splicing factor 3 (SRSF3 or SRp20) being a proto-oncogen

47 in, in conjunction with serine/arginine-rich splicing factor 3 (SRSF3) and SRSF10.

48 te-specific deletion of serine/arginine-rich splicing factor 3 (SRSF3) impairs hepatocyte maturation

49 Serine rich splicing factor 3 (SRSF3) plays a critical role in liver

50 or splicing factor, serine and arginine rich splicing factor 3 (SRSF3), was frequently upregulated in

51 Cancer-associated mutations of the core splicing factor 3 B1 (SF3B1) result in selection of nove

52 dentify the same hotspot somatic mutation in splicing factor 3 subunit B1 (SF3B1(R625H)) in 19.8% of

53 The RBP SRSF3 (serine/arginine-rich splicing factor 3) is essential for blastocyst formation

54 HCC (BCLC B/C) showed higher frequencies of splicing factor 3b subunit 1 (SF3B1) (P = 0.0003), TP53

55 ons in spliceosome components, including the splicing factor 3b subunit 1 (SF3B1), are associated wit

56 s currently the most potent modulator of the splicing factor 3b subunit 1 and used by dozens of resea

57 odysplastic syndrome (MDS) have mutations in Splicing Factor 3B, Subunit 1 (SF3B1).

58 we show that FANCI and FANCD2 associate with splicing factor 3B1 (SF3B1), a key spliceosomal protein

59 ere we report a protein related to the human splicing factor 45 (SPF45) named splicing factor for phy

60 Splicing factor 45 kDa (SPF45) is an alternative splicin

61 MLs) and identify new recurrent mutations in splicing factors (5/12 AMLs in SF3B1 and 2/12 AMLs in U2

62 tion of DHX38, encoding an USP39-interacting splicing factor, also reduces the viability of these cel

63 Shot summarizes our current understanding of splicing-factor alterations in cancers.

64 ion with a reovirus strain that targets this splicing factor alters splicing of cell mRNAs involved i

65 t DARPP-32 regulates the expression of SRp20 splicing factor and co-exists with it in the same protei

66 in RBFOX2 in DM1 heart tissue-due to altered splicing factor and microRNA activities-induces cardiac

67 function as a signal responsive trans-acting splicing factor and scaffold that recruits and stabilize

68 e first evidence of viral antagonism of this splicing factor and suggest that downstream consequences

69 efect is directly linked to the SC35 (SRSF2) splicing factor and to the presence of nuclear aggregate

70 The top hit was SNW1, a splicing factor and transcriptional coactivator.

71 I (RNAPII) elongation and the recruitment of splicing factors and adaptor proteins to chromatin compo

72 was found between gene expression changes in splicing factors and alternative spicing of other genes

73 d interaction with serine-arginine rich (SR) splicing factors and appearance of nuclear speckle-local

74 the arginine rich N-terminus interacts with splicing factors and binds to RNA.

75 f the test substrate promoted recruitment of splicing factors and consequent pre-mRNA structural remo

76 egulation by viral RNA cis elements and host splicing factors and offers potential therapeutic target

77 enous human cohesin interactome and identify splicing factors and RBPs as functionally significant co

78 Furthermore, cohesin-interacting splicing factors and RBPs followed the cohesin cycle and

79 Depletion of cohesin-interacting splicing factors and RBPs resulted in aberrant mitotic p

80 GSK-3-dependent phosphorylation of multiple splicing factors and regulators of RNA biosynthesis as w

81 und that cohesin interacts with a panoply of splicing factors and RNA-binding proteins (RBPs).

82 here remains much to be understood about the splicing factors and the cis sequence elements controlli

83 The interaction between splicing factors and the transcriptional machinery provi

84 ers of TNPO3, including SR domain-containing splicing factors and tRNAs that reenter the nucleus.

85 ith other U2AF ligand motif (ULM)-containing splicing factors, and further established that SF3b1 ass

86 ates with precursor messenger RNA (pre-mRNA) splicing factors, and inactivation of RBM39 by indisulam

87 tes of splicing-associated histone marks and splicing factors, and thereby unexpectedly could modulat

88 n rates, (ii) binding to pre-mRNA to recruit splicing factors, and/or (iii) blocking the association

89 bunits, CFIm, CPSF, and CstF; lack essential splicing factors; and associate with transcription elong

90 liceosomal proteins and accessory regulatory splicing factors are among the most common targets of so

91 t super-enhancers(7,8), and large numbers of splicing factors are concentrated in nuclear speckles, s

92 ontrast to their GMAS targets, the predicted splicing factors are more conserved than expected, sugge

93 Mutations in RNA splicing factors are the single most common class of gen

94 Variants in PRPF31, a splicing factor, are a common cause of autosomal dominan

95 mplified system with fewer than half as many splicing factors as humans.

96 d identify USP39, which encodes an essential splicing factor, as a critical gene for the viability of

97 nRNPA1, an RNA-binding protein and auxiliary splicing factor, as a substrate of TRAF6.

98 response induced by driver mutations of key splicing factors associated with myelodysplastic syndrom

99 ssion of relevant spliceosome components and splicing factors (at mRNA and protein levels) in well ch

100 SR45 is an unusual SR splicing factor bearing two RS domains.

101 of transcripts, as is enrichment for several splicing factor binding motifs.

102 ogate the detrimental sequestration of MBNL1 splicing factor by nuclear RNA foci and consequently MBN

103 report the engineering of CRISPR Artificial Splicing Factors (CASFx) based on RNA-targeting CRISPR-C

104 Here we demonstrate that expression of the splicing factor CELF2 (CUGBP, Elav-like family member 2)

105 Thus, LEDGF/p75 interacts with splicing factors, contributes to exon choice, and direct

106 report that SON, previously known as an RNA splicing factor, controls MLL complex-mediated transcrip

107 d CCA1 intron in vitro, suggesting that this splicing factor could be involved in regulation of intro

108 KI-7 expression is tightly controlled by RNA splicing factors CUG-BP and hnRNPM through direct bindin

109 n between its central protein, eIF4AIII, and splicing factor CWC22, we found that eIF4AIII and the ot

110 ugh interaction with SRSF3, a host oncogenic splicing factor differentially expressed in epithelial c

111 rovide functional evidence that mutations in splicing factors drive myeloid malignancy development, a

112 riation, mutations within the gene body, and splicing factor dysregulation.

113 Depletion of this cell splicing factor enhances reovirus replication and cytopa

114 ed that mice lacking the epithelial-specific splicing factor Esrp1 have fully penetrant bilateral cle

115 ining non-coding mutations in well-known RNA splicing factors exhibit similar gene expression signatu

116 om patients and controls, we identified four splicing factors exhibiting significantly altered expres

117 suggest that age-associated dysregulation of splicing factor expression and cellular senescence may d

118 ine/Threonine kinase inhibitor SH-6 restored splicing factor expression and reversed both hormone sta

119 ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence.

120 tream targets of the ERK and AKT pathways on splicing factor expression, cellular senescence, and pro

121 AKT and ERK pathways led to up-regulation of splicing factor expression, reduction in senescent cell

122 Recently, we identified a factor called SPLICING FACTOR FOR PHYTOCHROME SIGNALING (SFPS) that di

123 o the human splicing factor 45 (SPF45) named splicing factor for phytochrome signaling (SFPS), which

124 DAMAGE REPAIR/TOLERATION PROTEIN111 (DRT111)/SPLICING FACTOR FOR PHYTOCHROME SIGNALING is a splicing

125 nerally thought to activate the SR family of splicing factors for efficient splice-site recognition,

126 pecific cargoes such as serine/arginine-rich splicing factors from the cytoplasm to the nucleus.

127 e isoform of the pan-eukaryotic Srrm2/SRm300 splicing factor gene, and subsequently became fixed in t

128 Moreover, GMAS-related splicing factors had stronger consensus motifs than expe

129 Recurrent mutations in core splicing factors have been reported in several clonal di

130 Relatively few splicing factors have been shown to be specific to the m

131 Recurrent mutations in splicing factors have emerged as a hallmark of several h

132 iates with GGGGCC repeat RNA in vitro is the splicing factor hnRNP H, and that this interaction is li

133 n the E6 ORF through interaction with a host splicing factor, hnRNP A1, and regulates E6 and E7 expre

134 Recently, the splicing factor hnRNPA2/B, which is decreased in Alzheim

135 dulation impacts on endogenous expression of splicing factors (HNRNPF and HNRNPH1) and on AS of MS-as

136 genome stability proteins, we find that the splicing factor Hsh155 disassembles from its partners an

137 An RNAi screen on splicing factors identified the little studied ZRANB2 an

138 rnative splicing but also revealed how these splicing factors impact functional properties of the hea

139 cing factor 45 kDa (SPF45) is an alternative splicing factor implicated in breast and lung cancers, a

140 the most frequently mutated gene encoding a splicing factor in a variety of hematologic malignancies

141 SF3B1 is the most commonly mutated RNA splicing factor in cancer(1-4), but the mechanisms by wh

142 SF3B1 is the most frequently mutated splicing factor in cancer, and SF3B1 mutants corrupt bra

143 p40A, a homologue of Prp40, an essential RNA-splicing factor in the budding yeast.

144 irst time the role of DARPP-32 in regulating splicing factors in gastric cancer cells.

145 events and characterize potential associated splicing factors in HD.

146 STAR proteins differ from most splicing factors, in that they contain a single RNA-bind

147 vered recurrent somatic mutations within RNA splicing factors, including SF3B1, SRSF2, U2AF1 and ZRSR

148 Knockdown of several splicing factors increased BMP4-dependent transcription

149 no functional evidence that mutations in RNA splicing factors initiate leukaemia.

150 17 (bZIP17), and the membrane-associated RNA splicing factor, INOSITOL REQUIRING ENZYME1 (IRE1).

151 on for splice sites and that combinations of splicing factors interact at cis regulatory sites on pre

152 n of serine/arginine rich (SR) proteins, the splicing factors involved in the production of FN isofor

153 The observed reduction in splicing factors is consistent with the elimination of s

154 r of the serine/arginine-rich (SR) family of splicing factors, is one of the mutation targets associa

155 migration indicated that SRPK1, encoding the splicing factor kinase SRSF protein kinase 1, is relevan

156 how reduced expression of this core pre-mRNA splicing factor leads to craniofacial defects.

157 ide insight into how the loss of a subset of splicing factors leads to a failure of centriole duplica

158 ide screen revealed that depletion of 14 RNA splicing factors leads to a specific defect in centriole

159 The enrichment of numerous splicing factors like hnRNP proteins before ZGA was surp

160 regulate exon 13 inclusion via trans-acting splicing factors like PTBP1 and TIAL1.

161 NA co-localizes with and sequesters the mRNA-splicing factor MBNL1, leading to missplicing of essenti

162 Here we demonstrate that the RNA alternative splicing factor MBNL1, which is sequestered in nuclear R

163 rocessing requires the conserved alternative splicing factor MEC-8/RBPMS.

164 CLIP-seq/RIP-seq datasets involving numerous splicing factors, microRNAs and m6A RNA methylation.

165 condensation, speckle enlargement, decreased splicing factor mobility, and defective mRNA export.

166 lter the strongest consensus position of the splicing factor motif, except the more than 100 GMAS SNV

167 utant alleles of nab2 and genes encoding the splicing factor, MUD2, and the RNA exosome, RRP6, with i

168 erize genome instability phenotypes in yeast splicing factor mutants and find that mitotic defects, a

169 everal mRNA isoforms promoted by the various splicing factor mutants comprise a premature termination

170 Splicing factor mutations change the pattern of splicing

171 Splicing factor mutations tend to occur in the founding

172 an emphasis on the clinical consequences of splicing factor mutations, mechanistic insights from ani

173 We previously reported that the SR45 splicing factor negatively regulates glucose signaling d

174 hannels; this requires nuclear export of the splicing factor Nova-2.

175 model gene, we show the coordination of the splicing factors NOVA1 and PTBP1 in cancer by regulating

176 We recently described one such splicing factor, NOVA1, that acts as an enhancer of FL h

177 The splicing factor NOVA2, which binds directly to L1CAM pre

178 heterodimer of the U2AF1 and U2AF2 pre-mRNA splicing factors nucleates spliceosome assembly at polyp

179 ults indicate that the SLO3 PPR protein is a splicing factor of nad7 intron 2 in Arabidopsis mitochon

180 ascribe a mechanistic function to individual splicing factors or even to discern which are critical f

181 Pre-mRNA splicing factors play a fundamental role in regulating t

182 exes, which serve as cis-elements to recruit splicing factors, play a critical role in regulating alt

183 Here we identify SFPQ (splicing factor, poly-glutamine rich) as an RBP that bin

184 SCs, and its processing is suppressed by the splicing factor PPIE, which is highly expressed in mESCs

185 nd that it binds with higher affinity to the splicing factor pre-mRNA-processing factor39-1 (PpPRP39-

186 LICING FACTOR FOR PHYTOCHROME SIGNALING is a splicing factor previously shown to interact with phytoc

187 e top candidates include three host proteins splicing factor proline and glutamine rich (SFPQ), non-P

188 omain containing octamer-binding protein and splicing factor proline/glutamine-rich.

189 The splicing factors PRPF4B and BUD31 and the transcription

190 The pre-mRNA splicing factor PRPF8 is a crucial component of the U5 s

191 responsible for increased expression of the splicing factor PTBP1 (polypyrimidine tract binding prot

192 oreover, follow-up molecular analyses of one splicing factor PTBP1 revealed its impact on disease-ass

193 In PH, miR-124, through the alternative splicing factor PTBP1, regulates the PKM2/PKM1 ratio, th

194 s driving Alzheimer's disease, including the splicing factor PTBP1.

195 led functional analysis of the top candidate splicing factor, Ptbp1, revealed that it is a critical b

196 cripts, which can sequester the trans-acting splicing factor PTBP2.

197 rose gradients with the previously described splicing factors Raa1 and Raa2.

198 1213 created a putative binding site for the splicing factor RBFOX2 and was associated with increased

199 Here, we demonstrate that splicing factor Rbfox2 is expressed in the neural crest

200 We hypothesized that alternative splicing factors RBFOX2 and RBFOX1 might mediate splicin

201 d Variants in the cardiomyocyte-specific RNA splicing factor RBM20 have been linked to familial cardi

202 ally, and are targets of the muscle-specific splicing factor RBM20.

203 We determined that the splicing factor RBM47 is downregulated during EMT and al

204 The multi-domain splicing factor RBM5 regulates the balance between antag

205 Gsk3 DKO reduced phosphorylation of the splicing factors RBM8A, SRSF9, and PSF as well as the nu

206 The interaction between cohesin and splicing factors/RBPs was RNA- and DNA-independent, occu

207 Somatic mutations of pre-mRNA splicing factors recur among patients with myelodysplast

208 Accordingly, AS of the putative splicing factor REDUCED RED-LIGHT RESPONSES IN CRY1CRY2

209 The Rbfox family of splicing factors regulate alternative splicing during an

210 It is generally thought that splicing factors regulate alternative splicing through b

211 The NOVA splicing factors regulate the developmental expression o

212 Here we show that SRp55, a splicing factor regulated by the diabetes susceptibility

213 Here, we identified 1723 AS events and 41 splicing factors regulated in a breast cancer cell model

214 ssion of proteins with relevant functions in splicing factor-related diseases both in association wit

215 15, a DEAH box containing RNA helicase, is a splicing factor required for the last step of splicing.

216 ered subnuclear organization specifically of splicing factors required for A complex formation, which

217 inding protein that associates with the core splicing factor RNA binding motif protein 39 (RBM39) and

218 possible recently through inhibition of the splicing factor RNA binding motif-20.

219 The splicing factor RNA-binding motif 20 (RBM20) regulates t

220 genetic screens in C. elegans, we identified splicing factor RNP-6/PUF60 whose activity suppresses im

221 The splicing factor SC35/SRSF2 binds to nuclear RNA and faci

222 Here, we showed that a major splicing factor, serine and arginine rich splicing facto

223 The RNA isoform repertoire is regulated by splicing factor (SF) expression, and alterations in SF l

224 Specifically, TP53 (p=0.01) and splicing factor (SF, SF3B1, ZRSR2, SRSF2; p<0.001), but

225 Mutations in the splicing factor SF3B1 are found in several cancer types

226 One of these, the pre-mRNA splicing factor SF3B1, is also frequently mutated in can

227 Genes encoding the RNA splicing factors SF3B1, SRSF2, and U2AF1 are subject to

228 metrically dimethylates arginine residues on splicing factor SF3B2 (SAP145) and has been functionally

229 ion-resistance, eliciting its binding to the splicing factor SF3B3.

230 Another longevity promoting splicing factor, SFA-1, similarly exerts an immuno-suppr

231 Complete loss of function of the ubiquitous splicing factor SFPQ affects zebrafish motoneuron differ

232 ether, we uncover the axonal function of the splicing factor SFPQ in motor development and highlight

233 r-associated mutations in genes encoding RNA splicing factors (SFs) commonly occur in leukemias, as w

234 r approach identified lysine 130 of the mRNA splicing factor snRNP70 as a SETMAR substrate in vitro,

235 aH1 cells, as were some serine arginine rich splicing factor splicing activator and heterogeneous rib

236 The Ser/Arg (SR)-rich splicing factor (SRSF) protein kinase (SRPK), which is i

237 Splicing factor SRSF1 is upregulated in human breast tum

238 ay activation and induction of the oncogenic splicing factor SRSF1.

239 HIV-1 promoter is regulated by the cellular splicing factor SRSF1.

240 tein phosphatase 1 (PP1) with the SR protein splicing factor (SRSF1) to understand the foundation of

241 kles, where it forms a complex with the mRNA splicing factor SRSF2 and alters its subnuclear localiza

242 the first report of viral antagonism of the splicing factor SRSF2 and identifies the viral protein t

243 Here, we show that mice lacking the splicing factor SRSF2 but not SRSF1 in hepatocytes have

244 Here we report that mutations affecting the splicing factor SRSF2 directly impair hematopoietic diff

245 Oncogenic mutations in the RNA splicing factors SRSF2, SF3B1, and U2AF1 are the most fr

246 ypoxia-induced expression and binding of the splicing factor SRSF3, and increased binding of total an

247 There is evidence to suggest that the splicing factor SRSF6 is involved in the mechanism that

248 SR splicing factors (SRSFs) control splicing but can also c

249 n caused increased levels of the cellular SR splicing factors (SRSFs) SRSF1 (ASF/SF2), SRSF2 (SC35),

250 e gene is controlled by serine/arginine-rich splicing factors (SRSFs), and HPV16 infection induces ov

251 nding motif protein 25 (RBM25) is a putative splicing factor strongly conserved across eukaryotic lin

252 red for the IE2's fourth intron to bind to a splicing factor such as U2AF65, as determined by an RNA

253 peats form hairpin structures that sequester splicing factors such as muscleblind-like 1 (MBNL1).

254 finding that human ARS2 also interacts with splicing factors suggests a conserved mechanism mediates

255 combined with loss-of-heterozygosity in the splicing factor SUGP1 in five of these cases.

256 ional CAD risk genes, including the putative splicing factor SUGP1 Indeed, we found that rs10401969 r

257 ls splicing of ABI3 and acts upstream of the splicing factor SUPPRESSOR OF ABI3-ABI5.

258 oncentrating hormone receptor 1 (MCHR1), and splicing factor SWAP homolog (SFRS8)] was associated wit

259 The transcription elongation and pre-mRNA splicing factor Tat-SF1 associates with the U2 small nuc

260 omolog of human transcription elongation and splicing factor, TCERG1, has opposite effects on lifespa

261 NA binding motif protein 48 (RBM48) is a U12 splicing factor that functions to promote cell different

262 uclear ribonucleoprotein complex and several splicing factors that are commonly mutated in cancer.

263 Several additional splicing factors that are required for centriole duplica

264 However, the scope of splicing factors that govern alternative splicing in the

265 k genes in fungi, plants, and flies, but the splicing factors that modulate these effects to ensure c

266 Serine-arginine (SR) proteins are essential splicing factors that promote numerous steps associated

267 eport suggesting that MCM7 is a critical RNA splicing factor, thus giving significant new insight int

268 this motif are necessary for the binding of splicing factors TIA1 and Pcbp1 and that these proteins

269 ) and narrowing tra function (from a general splicing factor to dedicated regulator of dsx).

270 Very few splicing factors to date have been described to interact

271 differentially regulates RNA processing and splicing factors to drive T cell differentiation.

272 ole of combinatorial regulation by different splicing factors to fine tune gene expression programs d

273 ort on the impact of mutated or dysregulated splicing factors to hematopoiesis, mRNA splicing, and MD

274 P1 to RNAPIIo and for the recruitment of RNA splicing factors to the actively transcribed chromatin,

275 NA synthesis, ZFP106 translocates with other splicing factors to the nucleolus.

276 translocation of Hnrnpa1 and other pre-mRNA splicing factors to the nucleus in a transcription-depen

277 licing by sterically blocking the binding of splicing factors to the pre-mRNA, are a promising therap

278 s and association with alternative splicing (splicing factors), transcript abundance (AGO2) and mRNA

279 How the essential pre-mRNA splicing factor U2AF(65) recognizes the polypyrimidine (

280 The essential splicing factor U2AF2 recognizes a polypyrimidine-tract

281 Recurrent mutations in the splicing factor U2AF35 are found in several cancers and

282 uclear localization and interaction with the splicing factor U2AF65, which promotes mRNA processing a

283 In mammalians and yeast, the splicing factor U2AF65/Mud2p functions in precursor mess

284 Here, we identified an additional pre-mRNA splicing factor, WBP11, as a novel protein required for

285 To understand how SRPK1 phosphorylates this splicing factor, we performed mass spectrometric and kin

286 licing event is likely regulated by multiple splicing factors, we identified the SRSF3 oncoprotein as

287 The loss of genes that encode RNA splicing factors weakens cancer cells in a way that coul

288 In particular, we observed that splicing factors were not necessarily enriched at exon j

289 Mutations in genes encoding splicing factors (which we refer to as spliceosomal gene

290 Since nuclear speckles are storage sites for splicing factors, which leave these sites to splice cell

291 that nuclear speckles are storage sites for splicing factors, which leave these sites to splice cell

292 Splicing factors, which orchestrate this process, demons

293 erved Pir2(ARS2) protein in association with splicing factors, which recruit RNA processing and chrom

294 rs, and/or (iii) blocking the association of splicing factors with pre-mRNA.

295 splicing include RNA-protein interactions of splicing factors with regulatory sites termed silencers

296 dicted that GMAS SNVs often alter binding of splicing factors, with SRSF1 affecting the most GMAS eve

297 MeCP2 and its partners, splicing factor Y-box binding protein 1 (YB-1) and methy

298 RBM48 is coselected with the U12 splicing factor, zinc finger CCCH-type, RNA binding moti

299 s1076560(T) disrupted a binding site for the splicing factor ZRANB2, diminished binding affinity betw

300 3 (RGH3) protein is orthologous to the human splicing factor, ZRSR2.