ライフサイエンスコーパス: splicing pattern

1 understanding of the molecular basis of the splicing pattern.

2 -sequence changes created its human-specific splicing pattern.

3 ion or stability of MAPK mRNA but alters its splicing pattern.

4 e levels of SMN protein due to its defective splicing pattern.

5 ecular weight form that was dependent on the splicing pattern.

6 mp20(-/-)mice revealed no differences in the splicing pattern.

7 regulators that mediate the neuron-specific splicing pattern.

8 cing pattern was distinct from the canonical splicing pattern.

9 re cycling through its modulation of the tim splicing pattern.

10 -isobutyl-1-methylxanthine) also changed the splicing pattern.

11 a competitive advantage to the exon-skipping splicing pattern.

12 tere phenotype and second for effects on the splicing pattern.

13 for dominant effects on the Ubx alternative splicing pattern.

14 a dramatic sequence variation and a complex splicing pattern.

15 (in the C57BL/6 strain) changes the pre-mRNA splicing pattern.

16 nomic context using CRISPR/Cas9, changed the splicing pattern.

17 the transgenic mice, and had a more complex splicing pattern.

18 transcription and disruption of normal mRNA splicing patterns.

19 assay, we showed that c.790A>G altered CIZ1 splicing patterns.

20 These mutations alter pre-mRNA splicing patterns.

21 ntributor to the emergence of human-specific splicing patterns.

22 d 15 MIR exons with tissue-specific shift in splicing patterns.

23 y determined targets were unaltered in their splicing patterns.

24 were able to induce a change in alternative splicing patterns.

25 ition from non-NS to NS-specific alternative splicing patterns.

26 NA and coincided with reversion to embryonic splicing patterns.

27 result from use of alternative promoters and splicing patterns.

28 an SR proteins exhibit the same unproductive splicing patterns.

29 ls and to select cells that express specific splicing patterns.

30 a particular impact on pre-mRNA alternative splicing patterns.

31 es, and confirmed that ETR-3 regulates their splicing patterns.

32 ity, overlapping reading frames, and complex splicing patterns.

33 ture termination of HIV-1 RNAs, and abnormal splicing patterns.

34 ential to identify novel genes and elucidate splicing patterns.

35 in SMN2) is responsible for the alternative splicing patterns.

36 -processing defects and alternative pre-mRNA splicing patterns.

37 ormation to sort out the complex alternative splicing patterns.

38 ormal, and there are no major changes in the splicing patterns.

39 ifferences in cell-type-specific alternative splicing patterns.

40 exons play a role in determining alternative splicing patterns.

41 participate in the control of cell-specific splicing patterns.

42 trength and balance of interactions to alter splicing patterns.

43 actors that alter these relatively conserved splicing patterns.

44 ntrolling tissue and neuron subtype-specific splicing patterns.

45 different mechanisms of regulation of these splicing patterns.

46 nal activation, or modulation of alternative splicing patterns.

47 eled large-scale changes in mRNA alternative splicing patterns.

48 t Quaking (QKI) broadly promotes mesenchymal splicing patterns.

49 n-based effects that can change or determine splicing patterns.

50 chromatin binding and luminal expression and splicing patterns.

51 accurate information to identify meaningful splicing patterns.

52 histones modifications modulate alternative splicing patterns.

53 ession through altering alternative pre-mRNA splicing patterns.

54 plicing factors helping to establish meiotic splicing patterns.

55 The data also show that changes in mRNA splicing patterns accompany metastatic progression, whic

56 Here, we show that alterations in RNA splicing patterns across the human transcriptome that oc

57 hat ATP hydrolysis locks splice sites into a splicing pattern after stable U2 snRNP association to th

58 downregulated) show a reversion to neonatal splicing patterns after Celf1 re-expression in adults.

59 ases, specific inhibition of the IAV-induced splicing pattern also attenuates viral infection.

60 We have investigated the splicing pattern and expression of the kainate receptor

61 among U2 snRNPs and affects global pre-mRNA splicing pattern and extensive gene expression.

62 Ultraviolet radiation (UV) changed the splicing pattern and induced or increased expression of

63 These results indicate that both the splicing pattern and longevity of alpha 0 mRNA are regul

64 The splicing pattern and molecular structure of SR1D indicat

65 s (TB1) in cell culture revealed an aberrant splicing pattern and production of a stable small (0.95-

66 e deficiency increased the complexity of the splicing pattern and triggered the differential alternat

67 n in these tumors correlates with the FGFR-2 splicing pattern and with Akt phosphorylation and Akt3 e

68 nges in cell-fate-dependent gene expression, splicing patterns and allelic imbalances.

69 is applicable to the majority of alternative splicing patterns and can be used to quantify alternativ

70 SRSF10 in knockout cells recovered wild-type splicing patterns and considerably rescued the stress-re

71 , relying on a splice graph representing the splicing patterns and exon expression levels indicated b

72 ively spliced introns/exons, events, isoform splicing patterns and isoform peptide sequences.

73 with high affinity have been shown to alter splicing patterns and offer promise as therapeutics.

74 sociated with memory, and exhibits intricate splicing patterns and post-translational modifications.

75 y facilitates the interpretation of abnormal splicing patterns and the detection of genomic rearrange

76 y improves the performance in predicting the splicing patterns and their changes during hESC differen

77 s and techniques to detect alternative BRCA1 splicing patterns and their potential use in cancer diag

78 e may enhance transcription and reverse SMN2 splicing pattern, and has induced promising motor-functi

79 SHV K15 resembles LMP2A in genomic location, splicing pattern, and protein structure and by the prese

80 model the between-sample correlation in exon splicing patterns, and a Markov chain Monte Carlo (MCMC)

81 pported by polyadenylation data, alternative splicing patterns, and RT-PCR validation.

82 B. distachyon SCL33 splicing patterns are also strikingly conserved compared

83 pe B transmitted/founder viruses showed that splicing patterns are conserved, but with surprising var

84 GAIP/RGS19 alternative splicing patterns are differentially expressed in variou

85 Recent studies have highlighted that splicing patterns are frequently altered in cancer and t

86 Aberrant splicing patterns are frequently observed in cancer init

87 Polymorphisms that alter gene-splicing patterns are functionally very important becaus

88 Here, we demonstrate that alternative splicing patterns are irreversibly chosen at a kinetic s

89 te-deficient plants suggests that changes in splicing patterns are nutrient specific and not or not c

90 be difficult to detect and interpret because splicing patterns are often heterogeneous even in normal

91 Alternative splicing patterns are regulated by factors that direct t

92 C. elegans reveals that overall alternative splicing patterns are relatively unchanged.

93 Three different splicing patterns are used, and each type is found polya

94 scripts; five that resulted from alternative splicing patterns arising from the utilization of normal

95 ce exhibit the same tissue-specific aberrant splicing patterns as seen in FD patients.

96 of specific gene expression and alternative splicing patterns, as well as coexpression networks, ass

97 firm the deFuse results and identify unusual splicing patterns associated with fusion events.

98 Of note is that the alternative splicing patterns associated with U2AF1 mutations were a

99 Comparison of splicing patterns at orthologous loci in seven Drosophil

100 cluding multiple promoter sites, alternative splicing patterns, autoregulation, and stop codons.

101 xpression of a gene, but also changes in its splicing pattern between different tissues.

102 ds of splice junctions that exhibit distinct splicing patterns between tissue types or within the ner

103 tive cassette exons for changes in embryonic splicing patterns between wild-type and 12 different str

104 lovirus promoter mimicked 1B-promoter-driven splicing patterns but differed from 1A-promoter-driven s

105 oan gene transcripts exhibit neuron-specific splicing patterns, but the developmental control of thes

106 Alteration of correct splicing patterns by disruption of an exonic splicing en

107 Transcribed Alu sequences can alter splicing patterns by generating new exons, but other imp

108 Changes in alternative splicing patterns can result from both inherited and acq

109 Fibronectin mRNA alternative splicing patterns change from B+A+V+ to B+A-V+ during ch

110 en or among selected tumor types, or explore splicing pattern changes between tumor and adjacent norm

111 f the possibility that widespread changes in splicing patterns contribute to lymphocyte function duri

112 ripts across inbred strains of mice, and its splicing pattern cosegregates with the Pas1 allele.

113 ibroblasts, we speculate that a differential splicing pattern could conceivably lead to phenotypic re

114 Moreover, splicing patterns demonstrate previously unobserved leve

115 hat the CSHMT message levels and alternative splicing patterns display tissue-specific variations.

116 Some of the human-specific brain splicing patterns disrupt domains critical for protein-p

117 Alt-d mRNA shares the same coding region, splicing pattern, downstream untranslated region, and si

118 ched deletion mice show that RBMXL2 controls splicing patterns during meiosis.

119 Two regulators known to control splicing patterns during neuron and muscle differentiati

120 An altered SNX14 splicing pattern for a CCD case was demonstrated by RNA

121 We discuss the implications of this unusual splicing pattern for the diverse mechanisms of exon reco

122 ves a graphical or sequence-level summary of splicing patterns for a specific gene.

123 MBNL proteins promote opposite splicing patterns for cTNT and IR alternative exons, bot

124 The overall splicing patterns for exclusive and inclusive exons show

125 d MBNL1 in adult heart induces the embryonic splicing patterns for more than half of the developmenta

126 U2OSE64b and the p53-/- cells showed altered splicing patterns for the CD44 receptor.

127 Alternative splicing patterns for the engulfment and cell motility 1

128 The RNA splicing patterns for TNF, LT-alpha and LT-beta genes ar

129 ural regulatory element dictates alternative splicing patterns (for example, human cardiac troponin T

130 ene accurately recapitulates the alternative-splicing pattern found in humans.

131 tes two cryptic splice sites, and alters the splicing pattern from extant splice sites.

132 Similar splicing patterns have also been found with murine melan

133 l protein complement, and aberrations in the splicing pattern impair HIV-1 replication.

134 ly erythroid-specific, ie, distinct from the splicing patterns imposed on the same transcripts in non

135 ress different exon 4 variants, and that the splicing pattern in a given neuron can change over time.

136 /squid transcript, shows an altered pre-mRNA splicing pattern in PSI mutant testes.

137 ence of cross-species retention of a complex splicing pattern in the 3' portion of RPGR, the function

138 y alternatively spliced, and we describe its splicing pattern in the flight muscles, identifying a ne

139 rs changed little in either concentration or splicing pattern in the same cells.

140 We compared the E1a alternative splicing pattern in transcripts expressed from the full-

141 th other UGC elements disrupted the alpha-TM splicing pattern in transfected cells.

142 ller isoform is produced from an alternative splicing pattern in which two exons are skipped.

143 We identified different alternative splicing patterns in 35 genes comparing cells with mutan

144 Importantly, we found aberrant alternative splicing patterns in a mouse model of RTT.

145 ele-specific ACE minigenes generated similar splicing patterns in both ACE-expressing and non-express

146 Aberrant splicing patterns in cancers have been implicated in suc

147 Caenorhabditis elegans, we demonstrate that splicing patterns in different neurons are often distinc

148 However, programming of splicing patterns in engineered biological systems remai

149 or the acquisition of cardiomyocyte-specific splicing patterns in fibroblasts.

150 n (IBD) showed that LEDGF/p75 contributes to splicing patterns in half of the transcription units tha

151 P1 revealed its impact on disease-associated splicing patterns in HD.

152 Splicing patterns in human immunodeficiency virus type 1

153 UG and to act as an inhibitor of alternative splicing patterns in muscle.

154 ements have led to the discovery of aberrant splicing patterns in oncogenesis, while more recent adva

155 This study highlights the robustness of splicing patterns in plants and the importance of ongoin

156 Alternative splicing patterns in pollen and seedling were highly cor

157 ost likely due to recapitulation of neonatal splicing patterns in regenerating fibers.

158 Cells can change alternative splicing patterns in response to a signal, which creates

159 ound classes altered SMN mRNA levels or mRNA splicing patterns in SMA patient-derived fibroblasts.

160 Splicing patterns in somatic cells follow C. elegans con

161 irst demonstrations of identical alternative-splicing patterns in species that are separated by over

162 The establishment of efficient and stable splicing patterns in terminally differentiated cells is

163 T transcripts revealed two major alternative splicing patterns in the 5'-untranslated region (5'-UTR)

164 egy in mice, we show that mutually exclusive splicing patterns in the Ca(V)2.2 gene modulate N-type c

165 e as well as the altered gene expression and splicing patterns in the mutant.

166 channel, we systematically investigated the splicing patterns in the neonatal and adult rat hearts.

167 abditis elegans neurons, identifying complex splicing patterns in the neuronal kinase sad-1.

168 wide phylogenetic survey of lineage-specific splicing patterns in the primate brain, via high-density

169 DNAs demonstrated the occurrence of the same splicing patterns in these species.

170 cific exons in genes exhibiting differential splicing patterns in various cell types.

171 Analyses of the ewg splicing patterns in wild-type and ELAV-deficient eye im

172 ilar alterations in gene expression and mRNA splicing patterns, indicating that mislocalized FUS resu

173 of developmentally regulated calcium channel splicing patterns instructively alters differentiation i

174 The splicing pattern is cell-specific.

175 ate that the early, in contrast to the late, splicing pattern is not regulated by stage-specific or s

176 The embryonic splicing pattern is reproduced in primary skeletal muscl

177 The splicing pattern is tissue specific.

178 Variability in splicing patterns is a major source of protein diversity

179 streamlined graphical representation of gene splicing patterns is provided, and these patterns can al

180 g accurately identified the Qp-derived EBNA1 splicing pattern, lytic gene splicing, and a complex spl

181 yelofibrosis patients (14%) with distinct 3' splicing patterns, many of these with a protein-altering

182 Thus, mechanisms in addition to splicing patterns must control pyrin's subcellular distr

183 The splicing patterns observed in the Arabidopsis mutants pa

184 screens to detect compounds that affect the splicing pattern of a gene.

185 xpressed in various cancers, and shifted the splicing pattern of Bcl-x pre-mRNA from Bcl-x(L) to Bcl-

186 oligonucleotide (5'Bcl-x AS) that shifts the splicing pattern of Bcl-x pre-mRNA from the anti-apoptot

187 Analysis of the splicing pattern of ectopic transcripts in lymphocytes i

188 The exon-intron organization and splicing pattern of epilysin differ from that of other M

189 n a positive manner to mediate the embryonic splicing pattern of exon inclusion.

190 anges in splicing activity that modified the splicing pattern of Fas, a key pro-apoptotic, p53-induci

191 beta2 and TGF-beta1 modified the alternative splicing pattern of fibronectin pre-mRNA and enhanced th

192 Changes in the RNA splicing pattern of Ikaros occurred at two stages: (i) a

193 e compared the regulation of the alternative splicing pattern of LH2, both endogenously and in the mi

194 As in T cells, hnRNPLL also alters the splicing pattern of mRNA encoding the adhesion receptor

195 Meayamycin B switches the splicing pattern of myeloid cell leukemia factor 1 (MCL1

196 terpretation of BRCA2 variants affecting the splicing pattern of other essential exons.

197 ession in 293 cells, promotes a shift in the splicing pattern of RFXANK/Tvl-1 toward the transcriptio

198 The splicing pattern of specific isoforms of numerous genes

199 thereby alter the expression and alternative splicing pattern of target mRNAs.

200 egulates its expression without changing the splicing pattern of the ED-A segment.

201 ther variations in the SMN genes affects the splicing pattern of the genes.

202 hich SR proteins are responsible for AS, the splicing pattern of the GFP-intron-GFP reporter was inve

203 identify inter-individual differences in the splicing pattern of the GSTM4 gene, we used reverse tran

204 e find that VCP inhibition causes an altered splicing pattern of the large pruning gene molecule inte

205 Here we demonstrate that MBNL3 regulates the splicing pattern of the muscle transcription factor myoc

206 lines differentially affects the alternative splicing pattern of the same substrates, such as caspase

207 for snf in establishing the female-specific splicing pattern of the sex determination switch gene, s

208 in order to identify ones that can alter the splicing pattern of the SMN2 gene.

209 emonstrated that these mutations altered the splicing pattern of these genes.

210 ow that temperature dramatically changes the splicing pattern of tim in Drosophila.

211 The findings indicate that that the splicing pattern of transcripts of SPV and B19 is simila

212 We analyzed RNA deep sequencing to compare splicing patterns of 201 837 exons between the cases wit

213 Splicing patterns of a reporter gene that mimics the ear

214 nformation on the expression and alternative splicing patterns of any known gene.

215 However, the alternative splicing patterns of canine cTnT are different in develo

216 rrently with restoration of the normal adult-splicing patterns of four pre-mRNAs that are misspliced

217 t bicalutamide (Casodex) induced mesenchymal splicing patterns of genes including FLNB and CTNND1.

218 To assess its influence on the splicing patterns of genes involved in apoptosis, we per

219 lterations in gene expression and changes in splicing patterns of genes involved in differentiation a

220 ion, splicing regulation and the alternative splicing patterns of key genes in EndoC-betaH1 human bet

221 atabase was built upon genomic annotation of splicing patterns of known genes derived from spliced al

222 We analyzed the splicing patterns of known Tdp-43 target genes as well a

223 eciprocal regulation serves to fine tune the splicing patterns of many downstream target genes.

224 PTBP2 was found to maintain embryonic splicing patterns of many synaptic and cytoskeletal prot

225 nts of alternative splicing, we measured the splicing patterns of over two million (M) synthetic mini

226 nowing the identity, relative abundance, and splicing patterns of pollen transcripts will improve our

227 equence elements in the promoter that affect splicing patterns of pre-mRNAs, we analyzed effects of d

228 s displayed by heatmap analysis, and altered splicing patterns of RNA, as visualized by Sashimi plots

229 erved, as well as significant changes in the splicing patterns of SCN8A and SCN9A.

230 Further characterization of splicing patterns of several genes in MCF7 cells grown i

231 ssion of ASCO-RNA in Arabidopsis affects the splicing patterns of several NSR-regulated mRNA targets.

232 clear alterations in transcript profiles and splicing patterns of specific subsets of genes.

233 ute-2 (Ago-2) regulates alternative pre-mRNA splicing patterns of specific transcripts in the Drosoph

234 s that can be designed to specifically alter splicing patterns of target pre-mRNAs.

235 sual interface for exploring the alternative splicing patterns of TCGA tumors.

236 Furthermore, examination of splicing patterns of TDP-43 target genes in human ALS re

237 The observed splicing patterns of the med and medJ mutant transcripts

238 amined the tissue expression and alternative splicing patterns of these two isoforms.

239 not significantly affected, the alternative splicing patterns of two model pre-mRNAs switched in a m

240 n plant nuclei, we have analyzed the in vivo splicing patterns of two-intron constructs containing 5'

241 e Arabidopsis mutations lead to more complex splicing patterns often involving exon skipping.

242 pothesis testing of differential alternative splicing patterns on RNA-Seq data.

243 mary mRNA transcripts, thereby affecting the splicing pattern or coding potential of mature mRNAs.

244 ys through amino acid changes, alteration of splicing patterns or expression of genes, influencing th

245 umerous studies have indicated that aberrant splicing patterns or mutations in spliceosome components

246 lting in aberrant transcription, alternative splicing patterns, or both, thereby leading to DM.

247 upled with experimental examination of trans-splicing patterns, our comparative genomic analysis reve

248 ient to control the tissue-specific pre-mRNA splicing pattern prevalent in situ.

249 sents intuitive graphical representations of splicing patterns, read counts and various statistical s

250 ic discharges, a shift toward adult pre-mRNA splicing patterns, reduced myofiber hypertrophy and a de

251 e report genome-wide analysis of alternative splicing patterns regulated by four Drosophila homologs

252 Our results suggest that alteration of splicing pattern represents a new approach to modificati

253 Establishment of the correct Sxl splicing pattern requires the coordinate regulation of t

254 r presence of TRPC2 a and b and describe the splicing patterns responsible for their formation, as we

255 splice site pairing establishes alternative splicing patterns resulting in the generation of multipl

256 es significantly due to numerous alternative splicing patterns, resulting in a prioritization problem

257 the level of similarity to their alternative splicing patterns, revealing patterns of tissue-specific

258 ndothelial cells from the injured liver, the splicing pattern reverted to that of normal cells, i.e.,

259 Despite these differences, the isoform splicing pattern seen in normal human brain is replicate

260 atterns but differed from 1A-promoter-driven splicing patterns, suggesting that promoter identity aff

261 The splicing patterns surrounding exons 6 and 11 of COP1 in

262 arly transcripts have a unique 5' exon and a splicing pattern that differs from that of the late tran

263 nce results from a previously unreported RNA splicing pattern that eliminates not only the V region b

264 ysis revealed that BART transcripts with the splicing pattern that generates the RPMS1 open reading f

265 ons, many of which exhibit a muscle-enriched splicing pattern that is conserved in vertebrates.

266 dysregulation of Gomafu leads to alternative splicing patterns that resemble those observed in SZ for

267 ow symmetric trends and genes with symmetric splicing patterns that tend to have similar biological f

268 he c.915+15A>C variant caused a shift in tau splicing pattern to a predominantly exon 10+ pattern pre

269 8 toward the consensus sequence switches the splicing pattern to include exon 18 in all larval transc

270 n, almost 290 genes change their alternative splicing pattern upon Brd2 depletion.

271 Because of the complex splicing pattern, use of alternative 5'-untranslated exo

272 rosophila projectin, as well as the possible splicing patterns used to generate different isoforms.

273 cription start sites, termination sites, and splicing patterns using rapid amplification of cDNA ends

274 jointly control constitutive and alternative splicing patterns via paralog compensation to control pa

275 hat developmental control of the alternative splicing pattern was distinct from the canonical splicin

276 Once induced, the new splicing pattern was maintained over multiple cell divis

277 RSF3 expression in glioma tissues, and their splicing pattern was modified using a CRISPR/Cas9 approa

278 The splicing pattern was not altered by diabetes.

279 An alteration in splicing pattern was observed for hnRNP A2/B1, itself th

280 nsitive changes in precursor mRNA (pre-mRNA) splicing pattern, we mapped the transcriptome of Fe-defi

281 determination of alterations leading to this splicing pattern, we performed a pan-TCGA screening for

282 e circulating WBCs demonstrate similar SCN5A splicing patterns, we hypothesized that these WBC-derive

283 ied and the mutations which alter the normal splicing pattern were characterized.

284 Sequence elements regulating the alternative splicing pattern were mapped by in vitro splicing assays

285 Splicing patterns were confirmed with isolates from an i

286 Wild-type and mutant GABRG2 mRNA splicing patterns were determined in both BAC-transfecte

287 reported or detected in this study, and the splicing patterns were determined.

288 Such cell type-specific splicing patterns were found in both mouse cerebellum an

289 Identical splicing patterns were found in transcripts from human p

290 entiation-associated changes in erythroblast splicing patterns were identified, including the previou

291 Aberrant splicing patterns were rescued in DM1 cells, and product

292 Aret also potently promoted flight muscle splicing patterns when ectopically expressed in jump mus

293 ESS did not significantly change the normal splicing pattern where the nt 3225 3' splice site is alr

294 dal variation in messenger RNA abundance and splicing patterns, which we validate by RNA-fluorescence

295 bidopsis intron mutations exhibiting complex splicing patterns will help to address fundamental quest

296 gene is spliced into five exons and shows a splicing pattern with exon boundaries similar to those o

297 nger coding region shares a highly conserved splicing pattern with several other Gli family members i

298 pattern, lytic gene splicing, and a complex splicing pattern within the BamHI A region.

299 previous studies have documented alternative splicing patterns within 5' and 3' regions of mRNAs enco

300 acids or small molecules) that modulate the splicing pattern would be facilitated by systems with wh