1 ibution of the underlying mechanisms of rime splintering and freezing fragmentation.

2 imple mechanical effects, including bending, splintering, and rotation.

3                                 We show that SPLINTER detects indels (up to 4 bp) and substitutions i

4 vealed inferotemporal optic disc oedema with splinter haemorrhages in the right eye and mild disc oed

5 1 patients (87.2%) and included leukonychia, splinter hemorrhage, onychoschizia, and distal nail hype

6 otal erythema/ulceration (6 [15%]), and nail splinter hemorrhages (5 [12%]).

7 r ulcerated lesions (n = 27, 42%), subungual splinter hemorrhages (n = 19, 29%), apparent distal infl

8 tinal edema in the inferopapillary area, and splinter hemorrhages and soft exudate in the left eye.

9                                              Splinter hemorrhages can be a feature of the antiphospho

10                We describe a patient in whom splinter hemorrhages developed following radial artery p

11 ral papilledema, juxtapapillary exudates and splinter hemorrhages.

12                                              SPLINTER integrates information from the synthetic libra

13 the capsid, (iv) removal, fragmentation, and splintering of tail sections, and (v) baseplate damage (

14 efficient for SIP than the better-known rime-splintering process.

15 h run and a new computational approach named SPLINTER that detects and quantifies short indels and su

16 ystal explosion due to ejection of debris or splintering, the chiral PGA crystals respond to internal