ライフサイエンスコーパス: spontaneous activity

1 sting to unmask previously unknown pulses of spontaneous activity.

2 ponsiveness, consistently exhibited elevated spontaneous activity.

3 the generation, maintenance, and richness of spontaneous activity.

4 local cortical microcircuits to decorrelate spontaneous activity.

5 help to enlighten the mechanisms underlying spontaneous activity.

6 vascular regulation for both stimulation and spontaneous activity.

7 46 prolongs evoked release, without altering spontaneous activity.

8 ity generated by BCs rather than to initiate spontaneous activity.

9 used a dramatic loss of spatial coherence of spontaneous activity.

10 role of calcium signaling in regulating GoC spontaneous activity.

11 twork inhibition, followed by an increase in spontaneous activity.

12 rons (CINs) based on statistical measures of spontaneous activity.

13 poglycemia, reduce CSF glucose, and suppress spontaneous activity.

14 eir information coding by suppressing shared spontaneous activity.

15 anthanum alone was a potent inhibitor of the spontaneous activity.

16 cid, and carbenoxolone significantly blocked spontaneous activity.

17 rrelation index to investigate the nature of spontaneous activity.

18 rd 'window current' at rest, contributing to spontaneous activity.

19 cortex neurons displayed a 26% reduction in spontaneous activity.

20 of awake mice during visual stimulation and spontaneous activity.

21 This phenomenon was modulated by daily spontaneous activity.

22 tracking system in near-darkness to monitor spontaneous activity.

23 ained across the cortex by locally-generated spontaneous activity.

24 ortex displays rich, coordinated patterns of spontaneous activity.

25 e to these interregional interactions during spontaneous activity.

26 eased anterior piriform cortical single-unit spontaneous activity.

27 ces are robustly replayed during a regime of spontaneous activity.

28 yperexcitable state and for triggering their spontaneous activity.

29 experience, but guided by molecular cues and spontaneous activity.

30 nimally required amount of I(K1) suppressing spontaneous activity.

31 lly influence the amplitude and frequency of spontaneous activity.

32 tion, as well as in response variability and spontaneous activity.

33 rmal neuritogenesis and void of synchronized spontaneous activity.

34 esentation and by controlling the pattern of spontaneous activity.

35 erience on the systems-level organization of spontaneous activity.

36 ar membrane potential and thus reduces their spontaneous activity.

37 creased expression of Nav1.7 associated with spontaneous activity.

38 ntly increased visually evoked responses and spontaneous activity, a decreased signal-to-noise ratio

39 ow that copper is an endogenous modulator of spontaneous activity, a property of functional neural ci

40 ell activity elevates the synchronization of spontaneous activity across a broad frequency range and

41 t auditory cortical areas, and then recorded spontaneous activity across this defined network.

42 mechanisms could interact extensively, with spontaneous activity affecting the expression and functi

43 h early electrophysiological signs of muscle spontaneous activities and histological signs of muscle

44 n was associated with a rapid development of spontaneous activities and hyperexcitability of nocicept

45 mined by field potential recordings revealed spontaneous activities and pathological high-frequency o

46 We find that SynII(-) neurons have increased spontaneous activity and a reduced threshold for the ind

47 efore, elucidating conductances that mediate spontaneous activity and changes of firing pattern in th

48 We show that elevated and noisy spontaneous activity and contrast-dependent noisy spikin

49 Activation of feedback increased spontaneous activity and decreased stimulus selectivity

50 alized calcium signals, yet reduces afferent spontaneous activity and disrupts the timing of stimulus

51 red (IR) sensing of mice was used to monitor spontaneous activity and distress of mice.

52 Spontaneous activity and energy expenditure did not diff

53 ptive site of angiotensin release) displayed spontaneous activity and evoked responses to either elec

54 physiological consequences are a decrease in spontaneous activity and excessive excitation, likely to

55 These results indicate an increased spontaneous activity and faster deactivation of PDE6C co

56 g signal detection, norepinephrine decreased spontaneous activity and firing during stimuli, yet it s

57 Tg(sm/p22phox) mice displayed impaired spontaneous activity and increased mitochondrial ROS pro

58 factory sensory neurons have greatly reduced spontaneous activity and lack odour-evoked responses.

59 ervations indicate that there are changes in spontaneous activity and light-evoked responses in RGCs

60 ing in the brainstem inhibit inner hair cell spontaneous activity and may further refine maturation.

61 f stimulation in 1A fibers, besides 1B fiber spontaneous activity and mechanical sensitization in FMS

62 n as the network state) that include ongoing spontaneous activity and neuromodulation.

63 and blunted the impact of D2R activation on spontaneous activity and neuronal excitability.

64 ator norepinephrine modulates olfactory bulb spontaneous activity and odor responses so as to generat

65 y, OFF-transient RGCs displayed decreases in spontaneous activity and receptive field size.

66 MUA) from macaque V1, S1, and A1 during both spontaneous activity and sensory stimulation.

67 neural responses are highly variable during spontaneous activity and sensory stimulation.

68 1) current is required to inject to stop the spontaneous activity and suggests the use of the Ishihar

69 ient to maintain the intrinsically generated spontaneous activity and that patterned spontaneous acti

70 nhibition ratio impacts the structure of the spontaneous activity and the information transmission at

71 excitability of NPY neurons to modulate the spontaneous activity and the integration of synaptic inp

72 stent with predictions for modular networks, spontaneous activity and the rate of synchronized bursts

73 rams to identify groups of CINs with similar spontaneous activity and then asked how these groups map

74 Finally, alcohol failed to enhance RMTg spontaneous activity and to prolong RMTg-induced silenci

75 tained hiPSC-CM APs and CaTrs were used from spontaneous activity and under optical pacing in control

76 Our measurements during spontaneous activity and visual stimulation reveal an in

77 ns are highly irregular both during ongoing, spontaneous activity and when driven at high firing rate

78 lenged skin exhibited a greater incidence of spontaneous activity and/or abnormal after-discharges in

79 rols (n=20) on offspring energy expenditure, spontaneous activity, and body composition at 3, 6, and

80 ry responsiveness yet had minimal impacts on spontaneous activity, and cck expression induced the opp

81 obutyric acid (GABA) signaling, limits early spontaneous activity, and constrains dendritic growth.

82 atively unusual approach: the observation of spontaneous activity, and correlated patterns in spontan

83 ocomotion had two main effects: it increased spontaneous activity, and it weakened the suppressive si

84 e injury influenced the functional rewiring, spontaneous activity, and network plasticity following i

85 olarize the membrane potential, decrease the spontaneous activity, and reduce the intracellular Ca(2+

86 , we tracked receptive field reorganization, spontaneous activity, and response gain from individual

87 cells recruited during perceptual tasks and spontaneous activity are also turned off together as a u

88 In the auditory system, rhythmic bursts of spontaneous activity are generated in cochlear hair cell

89 ation shows that these changes in evoked and spontaneous activity are important for sound perception.

90 ay are understanding how patterns of ongoing spontaneous activity are modified by task performance an

91 has revealed that infraslow fluctuations in spontaneous activity are organized into stereotyped spat

92 and the spatial extent and frequency of the spontaneous activity are tightly regulated by stage.

93 s are electrophysiologically mature, display spontaneous activity, are surrounded by nonreactive astr

94 t common physiologic mechanisms may underlie spontaneous activity as imaged with fMRI in humans and s

95 2-electrode array (60 mum spacing) to record spontaneous activity at 20 kHz from up to 500 neurons si

96 nd the induced events propagate similarly to spontaneous activity at earlier stages, though without i

97 vidence that the precise temporal pattern of spontaneous activity before hearing onset is crucial for

98 rent input modulates, rather than initiates, spontaneous activity before hearing onset.

99 In sensory systems, patterned spontaneous activity before the onset of sensation is th

100 ound rhythmic patterns of global synchronous spontaneous activity between neurons, which depends on v

101 By contrast, synchronous spontaneous activity between non-neuronal cells is media

102 hotoactivation of VALopA not only suppresses spontaneous activity but also alters the maturation of t

103 play a significant role in the generation of spontaneous activity but are critical for the transition

104 e clustering, on the other hand, facilitated spontaneous activity but led to degenerating patterns of

105 Many developing circuits exhibit spontaneous activity, but its role in the synaptic organ

106 or nuclei involves a novel interplay between spontaneous activity, cadherin expression and gap juncti

107 During sequences of spontaneous activity, calcium signals recorded at each l

108 terspike intervals (ISIs) of cat ANFs during spontaneous activity can be modeled as resulting from re

109 ule cell layer, it is not known whether this spontaneous activity can be modulated in a long-term man

110 Studies of patterned spontaneous activity can elucidate how the organization

111 These apparent connections revealed during spontaneous activity coactivation by GCaMP3 were confirm

112 that co-time-tuned neurons exhibit enhanced spontaneous activity correlations that increase just pri

113 ler temperatures, coupled with a decrease in spontaneous activity, could also allow individuals to in

114 ecular guidance cues expressed in gradients; spontaneous activity-dependent axonal and dendritic remo

115 c effects contributed 3% and 8% of the SD of spontaneous activity-dependent GCaMP3 fluorescence when

116 antial evidence that altering the pattern of spontaneous activity disrupts refinement, but the mechan

117 Spontaneous activity drives early mammalian circuit deve

118 mice engineered to have very little afferent spontaneous activity due to the overexpression of the in

119 By correlating spontaneous activity during "resting states" [1], studie

120 neural circuits are established by patterned spontaneous activity during development.

121 However, similar Ca(2+)-dependent spontaneous activity during hypokalemia was only observe

122 In the human brain, spontaneous activity during resting state consists of ra

123 animate target significantly correlated with spontaneous activity during the resting state indexed by

124 mesoscale architectures in the regulation of spontaneous activity dynamics.SIGNIFICANCE STATEMENT Com

125 ses to sensory stimuli and exhibit intricate spontaneous activity even without external sensory input

126 d the frequency and pairwise correlations of spontaneous activity events in the primary visual cortex

127 els in the RTN are essential determinants of spontaneous activity ex vivo, and downstream effectors f

128 ing-state activity) is spontaneous, but this spontaneous activity exhibits a surprising level of spat

129 They often served as broker of spontaneous activity flow, confirming that hub nodes and

130 rbachol had a transient excitatory effect on spontaneous activity followed by a rapid weakening of ac

131 stic startle to assess tinnitus, we recorded spontaneous activity from fusiform cells, the principle

132 ur experiments argue for the dissociation of spontaneous activity from hard-wired developmental progr

133 ssociable: neuropeptide expression uncoupled spontaneous activity from sensory responsiveness, and un

134 we used two-photon calcium imaging to record spontaneous activity from the same set of cells in mouse

135 We record spontaneous activity from up to 150 neurons in the hippo

136 ergic agonist carbachol normally decorrelate spontaneous activity generated by deep layer prefrontal

137 neurons simultaneously to study patterns of spontaneous activity generated by these circuits under n

138 actions between cadherins, gap junctions and spontaneous activity governs neuron assembly, presaging

139 TB) to the lateral superior olive (LSO) this spontaneous activity guides the strengthening and silenc

140 While spontaneous activity has been shown to instruct map form

141 In human resting-state fMRI, spontaneous activity has been understood predominantly i

142 Cortical variability and spontaneous activity have been variously proposed to rep

143 he axotomized L5 spinal nerve attenuated the spontaneous activities in L4 DRG and pain behavior.

144 ce are effective mechanisms to desynchronize spontaneous activity in a spatiotemporal manner, while a

145 um imaging indicates that serotonin inhibits spontaneous activity in abdominal LK neurons.

146 ekplexia mutations, Q226E and V280M, induced spontaneous activity in alpha1 glycine receptors.

147 ondria complex (ER-mitochondria complex), or spontaneous activity in astrocytes.

148 Ongoing spontaneous activity in cortical circuits defines cortic

149 nnel alters the spatiotemporal properties of spontaneous activity in developing hippocampal and retin

150 ly knocking down Nav1.8 after SCI suppressed spontaneous activity in dissociated dorsal root ganglion

151 vestigate how the mesoscale structure shapes spontaneous activity in generic networks of rat cortical

152 rk reveals an instructive role for patterned spontaneous activity in guiding the functional developme

153 ls, activating L2/3 predominantly suppressed spontaneous activity in L5, whereas deactivating L2/3 ma

154 ls were used to quantify total body area and spontaneous activity in live embryos.

155 er and persisting spatiotemporal patterns of spontaneous activity in neuronal networks with neuron cl

156 l excitation in ZIv and caused inhibition of spontaneous activity in POm.

157 hesis by using two-photon calcium imaging of spontaneous activity in populations of retinal neurons a

158 in R-fMRI signals consistent with a role of spontaneous activity in representing task-relevant infor

159 Here we demonstrate a different role for spontaneous activity in sensory cortex: gating of sensor

160 Spontaneous activity in the absence of external input, i

161 n benzoate-both potent avermectins-abolished spontaneous activity in the absence of gross malformatio

162 indings provide new insight into the ongoing spontaneous activity in the awake and anesthetized state

163 extraretinal opsins early on, at a time when spontaneous activity in the developing CNS plays a role

164 Correlated spontaneous activity in the developing nervous system is

165 test this hypothesis, we recorded multiunit spontaneous activity in the fusiform soma layer (FSL) of

166 Spontaneous activity in the inner ear plays a critical r

167 sts, which reduce, but do not eliminate, the spontaneous activity in the IO.

168 Trial self-initiation decreases the rate of spontaneous activity in the majority of recorded cells.

169 ging, we studied spatio-temporal patterns of spontaneous activity in the optic tectum of Xenopus tadp

170 nges in spiking around an elevated baseline, spontaneous activity in the piriform cortex extends the

171 al both in vivo and in vitro, revealing that spontaneous activity in the prehearing cochlea promotes

172 onsmokers, only a few studies assessed brain spontaneous activity in the resting state in chronic smo

173 mework, based on predictive coding, in which spontaneous activity in the subcortical auditory pathway

174 ult auditory prediction is formed to explain spontaneous activity in the subcortical pathway, rather

175 Temporary circuits amplify spontaneous activity in the visual system of neonatal ra

176 GABAA receptors, whereas gabazine suppressed spontaneous activity in these receptors.

177 Interestingly, spontaneous activity in these regions also plays out ove

178 Y1 purinergic receptors dramatically reduced spontaneous activity in these three cell types.

179 morphology and architecture with respect to spontaneous activity in this population, we visualized t

180 demonstrate that cell-intrinsic blockade of spontaneous activity in vivo does not affect neuronal id

181 d to affect HR responses to isoproterenol or spontaneous activity in vivo or in SANC.

182 citatory postsynaptic currents and increased spontaneous activity in vivo.

183 critical contributor to that process is the spontaneous activity - in the form of limb twitches - th

184 taneous activity, and correlated patterns in spontaneous activity, in the "resting" brain.

185 eases whole-body oxygen consumption, reduces spontaneous activity, increases adiposity and glucose in

186 e we show that Drosophila astrocytes exhibit spontaneous, activity-independent microdomain Ca(2+) tra

187 +) mediated by experimental manipulations or spontaneous activity induce its transient redistribution

188 s activity are crucial for understanding how spontaneous activity influences circuit development.

189 To understand the source of the neuronal spontaneous activity, input to the tectum was systematic

190 Patterned spontaneous activity is a hallmark of developing sensory

191 One intriguing aspect of spontaneous activity is an apparent nonstationarity, or

192 easingly, functional connectivity mapping of spontaneous activity is being used to reveal the organiz

193 fers from the mammalian visual system, whose spontaneous activity is controlled by retinal waves.

194 maging (fMRI) in the resting state (R-fMRI), spontaneous activity is correlated between brain regions

195 However, intrinsic spontaneous activity is critical for axon branching and

196 Thus, spontaneous activity is driven primarily by activation o

197 EphA3/+) mice, demonstrating that correlated spontaneous activity is required for map heterogeneity.

198 Interestingly, spontaneous activity is sufficient for spatial refinemen

199 require visual experience to occur; rather, spontaneous activity is sufficient.

200 However, this spontaneous activity is suppressed by coupling to an ove

201 A prominent type of such spontaneous activity is the alpha rhythm, which influenc

202 ergic antagonists are known to abolish early spontaneous activity, it has long been assumed that spin

203 ion via patterns of coherent fluctuations in spontaneous activity, known as functional connectivity.

204 mitophagy-compromised mice displayed reduced spontaneous activity, loss of grip strength, and increas

205 nges in this activity, two key components of spontaneous activity maturation were revealed: (1) spind

206 a-fiber neurons (maximally by 19%) and basal spontaneous activity (maximally by 33%) in the rat trige

207 Our work indicates a framework for studying spontaneous activity measured by two-photon calcium imag

208 In both areas, spontaneous activity (measured during fixation while vie

209 in AIA mice exhibited a greater incidence of spontaneous activity, mechanically evoked after-discharg

210 As a result of depression during high spontaneous activity, more cartwheel interneurons were r

211 Spontaneous activity observed with resting-state fMRI is

212 nicotinic receptors, (2) independent on the spontaneous activity of cholinergic interneurons, and (3

213 ere is, in fact, a natural clustering of the spontaneous activity of CINs into six groups but that th

214 In the auditory system, spontaneous activity of cochlear inner hair cells (IHCs)

215 henotypes arose from concomitantly increased spontaneous activity of D1 medium spiny neurons (MSNs) a

216 The extent of inhibition depends on both spontaneous activity of GoCs and the excitatory synaptic

217 tic deletion of TMEM16A markedly reduces the spontaneous activity of IHCs and spiral ganglion neurons

218 ty to respond, latency, and preference), and spontaneous activity of individual L2/3 pyramidal neuron

219 Infra-red sensing to monitor spontaneous activity of mice showed that soy-tomato enri

220 C, we have visualized Ca(2+) dynamics during spontaneous activity of neuronal cultures as confirmed b

221 ed ZIP, induced a dose-dependent increase in spontaneous activity of neurons in dissociated cultures

222 ed ZIP, induced a dose-dependent increase in spontaneous activity of neurons in dissociated cultures

223 ne restores opioid responsiveness and blocks spontaneous activity of nociceptors after SCI.

224 A hyperexcitable state and spontaneous activity of nociceptors have been suggested

225 Circuit-specific recordings reveal that spontaneous activity of nucleus accumbens-projecting VTA

226 We also find that anxiety suppresses spontaneous activity of PFC neurons, and weakens encodin

227 The ionic mechanisms that support spontaneous activity of RTN neurons are unknown.

228 A hyperexcitable state and spontaneous activity of SCI-nociceptors have been propos

229 First, the spontaneous activity of sensory neurons falls.

230 The spontaneous activity of serotonergic neurons correlates

231 of presynaptic GABAb receptors gated by the spontaneous activity of somatostatin-expressing (Sst) in

232 In addition, the spontaneous activity of STN neurons in R6/2 mice was red

233 nction inhibitor carbenoxolone increases the spontaneous activity of suprachiasmatic nucleus neurones

234 The spontaneous activity of the brain shows different featur

235 ing (afferent) auditory system by inhibiting spontaneous activity of the IHCs.

236 we found that the strength of correlation in spontaneous activity of the individual cells varied as a

237 KEY POINTS: Spontaneous activity of the sensory inner hair cells sha

238 " (sensory evoked response) and the "noise" (spontaneous activity) of cortical responses.

239 zation of spatiotemporal network dynamics of spontaneous activity on the other.

240 nted on nogo trials, permitting us to assess spontaneous activity on trials in which a signal could h

241 ely small changes in key parameters, such as spontaneous activity or strength of the light manipulati

242 o any self-organising process facilitated by spontaneous activity or training.

243 rtical network recurrent circuitry generates spontaneous activity organized into Up (active) and Down

244 Interestingly, phase shifts observed during spontaneous activity paralleled latency differences for

245 euromodulator oxytocin differentially shapes spontaneous activity patterns across sensory cortices.

246 on inhibition in vitro as well its effect on spontaneous activity patterns in vivo.

247 natal development, sensory cortices generate spontaneous activity patterns shaped by both sensory exp

248 eurons and modulates specific features of V1 spontaneous activity patterns that are crucial for the w

249 exposure to pharmacological compounds-alter spontaneous activity patterns, which subsequently induce

250 -dependent correlation in sensory-driven and spontaneous activity patterns.

251 hich tune weak network connectivity based on spontaneous activity patterns: a Hebbian model, where co

252 Patterned spontaneous activity periodically displays in developing

253 oposed that genetically encoded programs and spontaneous activity play complementary but independent

254 Our data suggest that spontaneous activity plays a critical role not only in t

255 In the developing mouse hindbrain, spontaneous activity propagates widely and the waves can

256 tion, mutations, and drugs on ATP-driven and spontaneous activity, providing insights for understandi

257 t RLn, compared to the right, and pathologic spontaneous activity (PSA) of myoelectrical activity wit

258 Disuse-driven spontaneous activity pulses may help preserve functional

259 ons in mouse visual cortex, we observed that spontaneous activity reliably encoded a high-dimensional

260 During sleep, spontaneous activity renormalizes net synaptic strength

261 sts measuring traits, such as body position, spontaneous activity, respiration, tremors, body tone, a

262 ated spontaneous activity and that patterned spontaneous activity results from input from multisensor

263 es from baseline, spatiotemporal analyses of spontaneous activity revealed that LFP became spatially

264 Persistent spontaneous activity (SA) generated in the cell bodies o

265 st in part by long-lasting sensitization and spontaneous activity (SA) in peripheral branches of prim

266 mM) significantly decreased the amplitude of spontaneous activity (SA) in SCI bladder muscle strips.

267 Spontaneous activity shifts at constant experimental con

268 nships can be modulated by the properties of spontaneous activity, suggesting its instructive role fo

269 te aminotransferase inhibitor attenuated the spontaneous activity, suggesting that retrograde signals

270 hyperexcitable state and for promoting their spontaneous activity, suggesting that T-type calcium cha

271 Abstract Spontaneous activity supports developmental processes in

272 or, and another approximately 15% have their spontaneous activity suppressed.

273 At the earliest developmental stages, spontaneous activity synchronizes local and large-scale

274 acute tests, whereas 5g was active only in a spontaneous activity test.

275 display lower response variability and less spontaneous activity than V1 neurons.

276 The human brain shows spontaneous activity that is strongly correlated across

277 In all stimulus conditions and during spontaneous activity, the average LFP power at frequenci

278 During spontaneous activity, the reduction of correlation accom

279 We used magnetoencephalography recordings of spontaneous activity to characterize whole-brain functio

280 le is known about the capacity for patterned spontaneous activity to drive the maturation of receptiv

281 ons showed both stimulus-evoked activity and spontaneous activity under physiological parameters.

282 in vivo and in vitro population measures of spontaneous activity, using the LFP, EEG, MEG or fMRI su

283 -sensitive potassium (KATP) channels exhibit spontaneous activity via a phosphatidylinositol-4,5-bisp

284 Spontaneous activity was detected in 31% of silent nocic

285 reased stepwise to suprathreshold levels and spontaneous activity was enhanced.

286 Electromyographically, spontaneous activity was found in 10 of 14 patients and

287 At the network level, spontaneous activity was less synchronized over cortical

288 Spontaneous activity was not affected by antagonist appl

289 The spike count, CV(2), and m-FF of spontaneous activity were also elevated in amblyopic neu

290 howed temporally simple responses and little spontaneous activity, whereas MT cells were spontaneousl

291 During spontaneous activity, which is a characteristic of devel

292 e found that all neurons participate in this spontaneous activity, which is characterized by brain-wi

293 ycles may provide insight into mechanisms of spontaneous activity, which recently has been shown to c

294 1A receptors promote divisive suppression of spontaneous activity, while 5-HT2A receptors act divisiv

295 Retinal waves are correlated bursts of spontaneous activity whose spatiotemporal patterns are c

296 d a 384-well-based HCS assay that quantifies spontaneous activity within single zebrafish embryos aft

297 ared mice suggesting a differential role for spontaneous activity within thalamocortical and intracor

298 d signals, but also completely shut down the spontaneous activity within the IO, which affects the re

299 patterns were also present in recordings of spontaneous activity without any sensory stimulation and

300 mice) altered the temporal fine structure of spontaneous activity without changing activity levels.