ライフサイエンスコーパス: spontaneous mutation

1 that cells usually use and a major source of spontaneous mutation.

2 ia inter- and intragenomic recombination and spontaneous mutation.

3 reby limiting illegitimate recombination and spontaneous mutation.

4 ance, that is the propensity to change under spontaneous mutation.

5 integrity and do so, in part, by suppressing spontaneous mutation.

6 imply a role for yafN, yafO, and/or yafP in spontaneous mutation.

7 f Min 2 (Mom2) locus that is the result of a spontaneous mutation.

8 coli pol IV, which enhances the frequency of spontaneous mutation.

9 uivalent to approximately 100 generations of spontaneous mutation.

10 geting the pcaHG genes of A. tumefaciens for spontaneous mutation.

11 ern, though the condition has a high rate of spontaneous mutation.

12 Two sites showed selective enrichment of spontaneous mutations.

13 gnificantly different initial frequencies of spontaneous mutations.

14 arental origin trends for different types of spontaneous mutations.

15 should fail more safely in response to most spontaneous mutations.

16 mismatch repair (MMR) increases the risk of spontaneous mutations.

17 y involving pharmaceutical manipulations and spontaneous mutations.

18 out an accompanied increased accumulation of spontaneous mutations.

19 tuitous repair may be an important source of spontaneous mutations.

20 rotective mechanisms have elevated levels of spontaneous mutations.

21 t significantly increase the accumulation of spontaneous mutations.

22 tiology composed of dominant-acting de novo (spontaneous) mutations.

23 auses severe polyarthritis in bone phenotype spontaneous mutation 1 (BPSM1) mice.

24 s of PilC-mediated pilus phase variation and spontaneous mutation, a finding consistent with a role f

25 In this report, we analyze spontaneous mutations accumulated over thousands of gene

26 Spontaneous mutation accumulation (MA) experiments have

27 The polyploid state reduces spontaneous mutation accumulation by gene conversion, th

28 phenotype in such mice is due to accelerated spontaneous mutation accumulation, we crossed these muta

29 l responses degrade over time as a result of spontaneous mutation accumulation.

30 experienced an average of 370 generations of spontaneous mutation accumulation.

31 These spontaneous mutations affected two regions of the TolC p

32 The per-genome, per-generation rate of spontaneous mutation affecting fitness (U) and the mean

33 entation to deficiencies to map QTL at which spontaneous mutations affecting Drosophila abdominal and

34 ts are widely used to estimate parameters of spontaneous mutations affecting fitness.

35 Moreover, we found that mice carrying a spontaneous mutation allelic to the most common mutation

36 ia coli results in an increased frequency of spontaneous mutation and an imbalance in dNTP pool level

37 freading act in parallel pathways to prevent spontaneous mutation and cancer.

38 2 protein functions in a process that avoids spontaneous mutation and insures faithful meiotic chromo

39 yp-resistant Mom2R phenotype resulted from a spontaneous mutation and linkage analysis localized Mom2

40 tandard approach for inferring properties of spontaneous mutation and necessitates further developmen

41 data provide a better understanding of EBOV spontaneous mutation and suggest that ribavirin may have

42 ation of nuclease activities led to frequent spontaneous mutations and accumulation of incompletely d

43 potential for epistatic interactions between spontaneous mutations and QTL affecting bristle number o

44 nhance, rather than diminish, the effects of spontaneous mutations and recombinations.

45 the frequency and structure of primary-site spontaneous mutations and second-site suppressors result

46 ighlights the plasticity of TCSs mediated by spontaneous mutations and suggests that mutation-induced

47 uency ( approximately 10(-2) to 10(-4)) than spontaneous mutations, and all phenotypes were reversibl

48 The chemical events responsible for spontaneous mutation are also highly sensitive to temper

49 The rates and patterns of spontaneous mutation are fundamental parameters of molec

50 ble, error-prone DNA polymerase IV (DinB) in spontaneous mutation are resolved by the finding that mu

51 Our results suggest that rare spontaneous mutations are an important contributor to ri

52 Because a considerable fraction of spontaneous mutations are caused by TE insertions, where

53 mmonium are in AMT4 and a high proportion of spontaneous mutations are caused by transposon-related e

54 Using data on older donors, we show that spontaneous mutations are not uniformly distributed thro

55 Spontaneous mutations are stochastic events.

56 Spontaneous mutations are the source of genetic variatio

57 Spontaneous mutations are the source of new genetic vari

58 Estimates suggest that spontaneous mutations arise in about a third of those ce

59 Spontaneous mutations arising before or during use can i

60 Spontaneous mutations arising during ES cell culture may

61 E. coli nfi(-)alkA(-) strain protected from spontaneous mutations arising in saturated cultures and

62 In this study, we present evidence for two spontaneous mutations as the molecular basis for this SC

63 We have isolated a number of spontaneous mutations as well as constructed directed mu

64 Spontaneous mutations associated with cancer also lie do

65 The hyperlipidemia results from spontaneous mutation at a locus, Hyplip1, on distal mous

66 lectively neutral makes it possible to study spontaneous mutation at a new level of resolution.

67 ng cells, like other cells, probably undergo spontaneous mutation at a rate of 10(-9) per nucleotide.

68 , mutS60, results in almost normal levels of spontaneous mutations at 37 degrees C but above this tem

69 ein homology modeling showed the presence of spontaneous mutations at important residues within the G

70 Spontaneous mutations at numerous sites distant from the

71 While studying spontaneous mutations at the maize bronze (bz) locus, we

72 These results eliminate spontaneous mutation, between-strain complementation, an

73 We promoted the accumulation of spontaneous mutations by subjecting independent lineages

74 Rates of random, spontaneous mutation can vary plastically, dependent upo

75 The rough coat (rc) spontaneous mutation causes sebaceous gland (SG) hypertr

76 This is the first report of a spontaneous mutation causing HCM in a non-human species.

77 y, as demonstrated by increased frequency of spontaneous mutations, chromosome nondisjunction, and te

78 to demonstrate that the measured effects of spontaneous mutations, combined with stabilizing selecti

79 oximately a 100-fold increase in the rate of spontaneous mutation compared with prophage-free strains

80 Spontaneous mutations conferring drug resistance were co

81 The other three spontaneous mutations created the same frameshift near t

82 Mice carrying a spontaneous mutation, Dancer (Dc), exhibit CL/P in homoz

83 e-genome sequencing to identify nearly 1,000 spontaneous mutation events accumulated over approximate

84 were conducted to examine recombination and spontaneous mutation events within clusters of resistanc

85 NA represents a potential source of frequent spontaneous mutation for hyperthermophiles.

86 tions in a set of lines that had accumulated spontaneous mutations for 33 generations.

87 ls deficient in MMR are grown anaerobically, spontaneous mutation frequencies are reduced compared wi

88 Spontaneous mutation frequencies of JP26 mutY mutants, a

89 lementation of the JP26 mutY mutant restored spontaneous mutation frequencies to wild-type levels.

90 Spontaneous mutation frequencies were scored in cohorts

91 Strains lacking MutS exhibited increased spontaneous mutation frequencies, and reversion assays d

92 treated with DEA/NO had significantly higher spontaneous mutation frequencies, increased numbers of A

93 functional Fpg, MutY or Smn showed elevated spontaneous mutation frequencies; and, these mutator phe

94 em, termed mutators, which exhibit increased spontaneous-mutation frequencies.

95 howed that MmuNeil3 greatly reduced both the spontaneous mutation frequency and the level of FapyG in

96 ency, additional loss of Mbd4 does not alter spontaneous mutation frequency at the endogenous Dlb-1b

97 iability and no growth defects or changes in spontaneous mutation frequency but had increased sensiti

98 Spontaneous mutation frequency in somatic cells is appro

99 if the lack of poleta significantly elevates spontaneous mutation frequency in various organs and tis

100 We determined the spontaneous mutation frequency of EBOV, which is relevan

101 uorescent protein were used to determine the spontaneous mutation frequency of EBOV.

102 c) The deletion of e.1 does not increase the spontaneous mutation frequency of T4 phage.

103 oxidized [Fe-S] clusters, and decreased the spontaneous mutation frequency of the cells.

104 e are viable and do not show the increase in spontaneous mutation frequency or cancer incidence that

105 These results demonstrate that EBOV has a spontaneous mutation frequency similar to those of other

106 Spermatogenic cells exhibit a lower spontaneous mutation frequency than somatic tissues in a

107 urther, and the mutant had a slightly higher spontaneous mutation frequency than the wild type in the

108 sensitivity to stress-related chemicals and spontaneous mutation frequency).

109 osatellite instability (MSI) and an elevated spontaneous mutation frequency, characteristic of MMR-de

110 used to infect bacterial cells to obtain the spontaneous mutation frequency.

111 by organic peroxides and it had the highest spontaneous mutation frequency.

112 o oxidized [Fe-S] clusters, and decrease the spontaneous mutation frequency.

113 d not only strain-dependent increases in the spontaneous-mutation frequency but also shifts in mutati

114 estimates of the rate and fitness effect of spontaneous mutations generated by mutation accumulation

115 Spontaneous mutations generated in the ORF14, ORF16, and

116 Recently, genes responsible for these spontaneous mutations have been identified.

117 e11-Rad50-Nbs1 complex is essential, several spontaneous mutations have been noted in various cancers

118 Although spontaneous mutations have the potential to generate abu

119 evealed that the underlying genes of natural spontaneous mutations high pigment 1 (hp1), high pigment

120 Here, we present a novel spontaneous mutation in a mitochondrial-associated gene

121 A study of spontaneous mutation in Arabidopsis thaliana was initiat

122 A spontaneous mutation in Bruton's tyrosine kinase (Btk) i

123 ecombination could be an important source of spontaneous mutation in cells that are not proliferating

124 y reported that in the Nuc1 rat, which has a spontaneous mutation in Cryba1 (the gene encoding betaA3

125 letions appear to play a much larger role in spontaneous mutation in D. melanogaster than in H. sapie

126 s of retinal amacrine cells from mice with a spontaneous mutation in Down syndrome cell adhesion mole

127 investigate the molecular nature and rate of spontaneous mutation in Drosophila melanogaster, we scre

128 Analysis of mice that carry a spontaneous mutation in DSCAM (DSCAM(del17)) revealed gr

129 Moreover, mechanisms of spontaneous mutation in E. coli remain obscure.

130 Here, we identify a spontaneous mutation in GALC, GALCtwi-5J, that precisely

131 esults reveal that ZIKV evolved to acquire a spontaneous mutation in its NS1 protein, resulting in in

132 Mice with a spontaneous mutation in Ncf1, which encodes the NCF1 (p4

133 This trait was due to a spontaneous mutation in the gene encoding the transcript

134 Recently, a spontaneous mutation in the gene encoding trafficking pr

135 Here we characterize a new spontaneous mutation in the mouse, cappuccino (cno), tha

136 r these conditions, the bacterium acquires a spontaneous mutation in the putative promoter region of

137 Here we describe a spontaneous mutation in the Zdhhc13 (zinc finger, DHHC d

138 8- to 15-fold increases in the frequency of spontaneous mutation in their germlines.

139 rophages, macrophages from mice that carry a spontaneous mutation in TLR4 (P712H) were hyporesponsive

140 (sw/sw)) mice previously reported to carry a spontaneous mutation in Wnt1 share major features of OI

141 p a high-resolution picture of the effect of spontaneous mutations in a hypermutator (DeltamutS) stra

142 y serotype M1 GAS strains have high rates of spontaneous mutations in covS during invasive GAS infect

143 To detect spontaneous mutations in csrRS, mucoid and large colony

144 rs, which have been proposed to give rise to spontaneous mutations in DNA and misincorporation errors

145 Three populations were screened for spontaneous mutations in downy mildew resistance.

146 In mice carrying spontaneous mutations in Dscam (Dscam(del17) ; Dscam(2J)

147 y and mismatch repair, we accumulated 40,000 spontaneous mutations in eight diploid yeast strains in

148 Tumorigenesis was assisted by either spontaneous mutations in Kras or experimental introducti

149 ecame invasive; invasion was associated with spontaneous mutations in Kras.

150 ight on the source, frequency, and nature of spontaneous mutations in maize.

151 Spontaneous mutations in mice have already provided impo

152 ontribute significantly to the appearance of spontaneous mutations in microorganisms and in human dis

153 ts, more than half the leukemic mice develop spontaneous mutations in Notch1.

154 nthesis, our work identified the spectrum of spontaneous mutations in plastids and reveals that this

155 -lamp biomicroscopy, and ERG to discover new spontaneous mutations in strains from the Genetic Resour

156 However, both the rate and spectrum of spontaneous mutations in T. thermophilus resembled those

157 mouse models employed in sleep research have spontaneous mutations in the biosynthetic pathway(s) reg

158 The authors propose these two spontaneous mutations in the canine VMD2 gene, which cau

159 Routine characterization of spontaneous mutations in the gal operon guided the disco

160 auses of death worldwide, arises mainly from spontaneous mutations in the genome of Mycobacterium tub

161 far been described for these proteoglycans, spontaneous mutations in the human and induced deletions

162 Inherited or spontaneous mutations in the human homologue of the Dros

163 Here, we describe two new spontaneous mutations in the mouse Zpld1 gene, which wer

164 Spontaneous mutations in the murine Eda (Tabby) phenocop

165 Mice with spontaneous mutations in the PC-1 gene have hypermineral

166 different tissue specificities compared with spontaneous mutations in the same gene.

167 We have found that most spontaneous mutations in the thyA gene of Escherichia co

168 n mechanism, we identified and characterized spontaneous mutations in the tri-snRNP-specific protein,

169 e and a description of the properties of new spontaneous mutations in the unicellular green alga Chla

170 Further, spontaneous mutations in these subunits that impair axon

171 A number of spontaneous mutations in this antenna region cause the h

172 responsible for a significant proportion of spontaneous mutations in this cancer cell line.

173 )Ink4a/Arf(-/-) mNSC-derived tumors revealed spontaneous mutations in Tp53 in vivo with subsequent do

174 opportunity to investigate the formation of spontaneous mutations in vaccinia virus, which encodes i

175 e (pol) IV, a protein involved in increasing spontaneous mutations in vivo.

176 ion of PKR activity reduced the frequency of spontaneous mutations in vivo.

177 The nature of spontaneous mutations, including their rate, distributio

178 Loss of GpsB can be suppressed by spontaneous mutations, including within the gene encodin

179 If so, our data imply that one generation of spontaneous mutation increases the developmental time by

180 major forces are postulated to contribute to spontaneous mutations: intrinsic DNA polymerase errors,

181 Knowledge of the rate and nature of spontaneous mutation is fundamental to understanding evo

182 ave a mutator phenotype in which the rate of spontaneous mutation is greatly elevated, and they frequ

183 These results suggest that the site(s) of spontaneous mutation is in a gene(s) which lies upstream

184 Because spontaneous mutation is the source of all genetic divers

185 Understanding patterns of spontaneous mutations is of fundamental interest in stud

186 most direct and unbiased method of studying spontaneous mutations is via mutation accumulation (MA)

187 ce of a resistant subclone that has acquired spontaneous mutations largely independent of initial the

188 n serum transferrin (Trf) as the result of a spontaneous mutation linked to the murine Trf locus.

189 uble helix, Watson and Crick suggested that "spontaneous mutation may be due to a base occasionally o

190 munological reconstitution, drug-induced, or spontaneous mutation models in rodents.

191 With information on spontaneous mutations now available in a variety of orga

192 ur results show that much of the increase in spontaneous mutation observed in an exo1Delta strain is

193 A molecular analysis of spontaneous mutations observed for the nonirradiated tis

194 Transversions dominate the spectrum of spontaneous mutations observed here, whereas transitions

195 P) degradation of RNA is responsible for the spontaneous mutations observed in an MMR-deficient backg

196 urable effect, suggesting that a fraction of spontaneous mutations occur as a result of dinB polymera

197 lly very low, and it is widely accepted that spontaneous mutations occur at defined, but different, r

198 Spontaneous mutations occur at rates of ~10(-8) to 10(-9

199 urs while phage DNA is outside the host, and spontaneous mutations occur during phage DNA replication

200 n NH(4)(+)-limited chemostat, two sequential spontaneous mutations occurred.

201 --> T transitions, which are the most common spontaneous mutations occurring in living organisms and

202 rial cells varies widely depending on when a spontaneous mutation occurs during growth of the culture

203 udies, a synergistic increase in the rate of spontaneous mutations occurs in the absence of POLeta in

204 Spontaneous mutation of Fas (lpr) or FasL (gld) complete

205 Spontaneous mutation of the NPC-1 gene in mice generates

206 Here we report that spontaneous mutation of the transcription factor FOXP3 r

207 Our data show that spontaneous mutation of the transcriptional regulator ha

208 ombinant inbred congenic strain HcB-19 has a spontaneous mutation of the Txnip gene, and we now show

209 emains stable under cultural drift, i.e. the spontaneous mutation of traits in the population, still

210 Spontaneous mutations of a dominant allele (I or i(i)) t

211 Eleven spontaneous mutations of acetyl-CoA carboxylase have bee

212 of the nucleobases play fundamental roles in spontaneous mutations of DNA.

213 e a higher proportion of frameshifts than do spontaneous mutations of the same substrate.

214 ations in two sets of lines with accumulated spontaneous mutations on the second chromosome.

215 , E2f2-, and E2f3-deficient cells, either by spontaneous mutation or by conditional gene ablation, pr

216 netic breakdown of lethality systems by rare spontaneous mutations, or selection for inherent suppres

217 Another spontaneous mutation (P228H) in Gabrb1 also causes high

218 Spontaneous mutations play a fundamental role in the mai

219 inase mutants have an increased frequency of spontaneous mutation, possibly due to uracil misincorpor

220 These spontaneous mutations potentially result from disruption

221 s were at substantial densities, to minimize spontaneous mutation prior to irradiation.

222 These results shed further light on the spontaneous mutation process and on the possible basis f

223 We analyzed spontaneous mutation processes across multiple genomic r

224 stood about the genome-wide impact of MMR on spontaneous mutation processes and the extent to which M

225 or MMR exhibit a 10- to 100-fold increase in spontaneous mutation rate (mutator phenotype), and inact

226 rains exhibited comparable increases in both spontaneous mutation rate and chromosome aberrations.

227 However, present estimates of the spontaneous mutation rate and spectrum are derived from

228 on of recD2 confers a modest increase in the spontaneous mutation rate and that the mutational signat

229 Here, we directly estimated the spontaneous mutation rate by sequencing new Drosophila m

230 We recently found that an elevated spontaneous mutation rate can also result from increased

231 Recently, the genome-wide spontaneous mutation rate in inbred lines of Caenorhabdi

232 The maize spontaneous mutation rate is estimated to be 2.17 x 10(-

233 During cell division, the spontaneous mutation rate is expressed as the probabilit

234 We estimated a spontaneous mutation rate of at least 4 x 10(-9) substit

235 an explain why cancers arise even though the spontaneous mutation rate of differentiated mammalian ce

236 The spontaneous mutation rate of plasmid-borne lacS was 175-

237 balance probably contributes toward the high spontaneous mutation rate of the mitochondrial genome.

238 3-L612M S. cerevisiae strain has an elevated spontaneous mutation rate that is likely due to reduced

239 An argument is presented that the spontaneous mutation rate, the core of evolution theory,

240 -patch repair synthesis might lead to a high spontaneous mutation rate, unless subsequent steps in th

241 ll division exhibit substantial increases in spontaneous mutation rate.

242 e base editor, with a frequency close to the spontaneous mutation rate.

243 e, reduces DNA binding in vitro and elevates spontaneous mutation rates and resistance to MNNG treatm

244 processes requires that factors determining spontaneous mutation rates and spectra be identified and

245 NA backbone or mismatched base have elevated spontaneous mutation rates consistent with defective mis

246 A polymerases can also give rise to elevated spontaneous mutation rates if they are allowed to replic

247 e and repair, resulting in one of the lowest spontaneous mutation rates in the body.

248 Spontaneous mutation rates in the homozygous and heteroz

249 Dm mutants were identified corresponding to spontaneous mutation rates of 10(-3) to 10(-4) per gener

250 siae was identified on the basis of elevated spontaneous mutation rates of haploid cells deleted for

251 Over 70 years ago, increased spontaneous mutation rates were observed in Drosophila s

252 Typically, RNA viruses have high spontaneous mutation rates, which permit rapid adaptatio

253 narily conserved inhibitor of p53, caused by spontaneous mutation recently has been associated with a

254 was found to suppress the increased rates of spontaneous mutation, recombination, and chromosome loss

255 The spontaneous mutation resulting in this phenotype was not

256 We report here that spontaneous mutations resulting from replication errors,

257 For instance, spontaneous mutations resulting in non- functional alpha

258 We also identify the spontaneous mutation rib-vertebrae as a hypomorphic muta

259 time appears critical to the suppression of spontaneous mutation; second, 3 weeks following exposure

260 these organisms exhibit rates and spectra of spontaneous mutations similar to MMR-bearing species, su

261 ains deficient in RNH35 displayed a distinct spontaneous mutation spectrum of deletions characterized

262 seudogene divergence accurately reflects the spontaneous mutation spectrum.

263 port provides experimental evidence that the spontaneous mutation T544I is a tissue culture adaptatio

264 evidence showing that it is the result of a spontaneous mutation (T544I) specific to tissue culture

265 icate two-to threefold higher frequencies of spontaneous mutations than in the mouse, with most of th

266 The positional cloning of a spontaneous mutation that caused lipopolysaccharide resi

267 the molecular basis for high growth (hg), a spontaneous mutation that causes a 30-50% increase in po

268 Here we have studied a new spontaneous mutation that causes severe polyarthritis in

269 in a region containing blind-sterile (bs), a spontaneous mutation that causes spermatogenic defects a

270 Hemoglobin deficit (hbd) mice carry a spontaneous mutation that impairs erythroid iron assimil

271 6(lu/lu)mouse model, which harbors a natural spontaneous mutation that inactivates plzf.

272 enA mtrR penB gonococcal strain (PR100) as a spontaneous mutation that increased resistance to penici

273 (Wa-1) mice inherit an autosomal recessive, spontaneous mutation that results in a postnatal reducti

274 pinal tract defects in mice homozygous for a spontaneous mutation that truncates the Dcc transcript.

275 r-naked hairless (Hr(N)) is a semi-dominant, spontaneous mutation that was suggested by allelism test

276 used a frameshift reversion assay to examine spontaneous mutations that accumulate in yeast strains d

277 g resistance (MDR) transporters, we isolated spontaneous mutations that altered the substrate specifi

278 ents were identified in a genetic screen for spontaneous mutations that caused colonies of strain D39

279 Pif1-deficient cells, which was relieved by spontaneous mutations that eliminated their ability to f

280 on was initiated with the following premise: spontaneous mutations that increase virus release will b

281 n Oxytricha and a template that can transmit spontaneous mutations that may arise during somatic grow

282 Spontaneous mutations that restore spreading have been p

283 Spontaneous mutations that suppress arrest occur with a

284 Normal cells minimize spontaneous mutations through the combined actions of po

285 l mutability, as they possessed low rates of spontaneous mutation to drug resistance.

286 with each other and mismatch repair to limit spontaneous mutation to less than 1 per genome per cell

287 for a frequency as high as 2.8 x 10(-6) for spontaneous mutation to resistance to optochin and was 1

288 n frequency was accompanied by high rates of spontaneous mutation to rifampicin and nalidixic acid re

289 hpC mutants differed in their frequencies of spontaneous mutation to rifampin resistance and in their

290 correlated with DNA damage, the frequency of spontaneous mutation to rifampin resistance was studied.

291 These clones were prone to spontaneous mutation upon further propagation, however,

292 to measure the genome-wide mutation rate for spontaneous mutations, using measurements of traits in i

293 We discovered a new spontaneous mutation (vortex, symbol vtx) of Atp6v1b1 in

294 The nature of the spontaneous mutation was a single base-pair deletion in

295 n, we found that the rate of accumulation of spontaneous mutations was similar in fetuses produced by

296 Spontaneous mutations were accumulated for approximately

297 We obtained proof that the observed spontaneous mutations were responsible for improved fitn

298 in the low-risk families is mainly caused by spontaneous mutation with high penetrance in males and r

299 nce exchange between strains as well as from spontaneous mutation, with interstrain recombination bei

300 vironments during chronic infection involves spontaneous mutations, yet changes underlying adaptive p