ライフサイエンスコーパス: spontaneously hypertensive rat

1 MT- 3 infusion was also investigated in SHR (spontaneously hypertensive rats).

2 y approximately 15 mm Hg, exclusively in the spontaneously hypertensive rat.

3 term reduction in high blood pressure in the spontaneously hypertensive rat.

4 id formation and renal function in the young spontaneously hypertensive rat.

5 al cerebral ischemia and 24 h reperfusion in spontaneously hypertensive rats.

6 e similar in the kidneys of Wistar-Kyoto and spontaneously hypertensive rats.

7 cle in vitro and decreases blood pressure in spontaneously hypertensive rats.

8 ng mice, mice with diet-induced obesity, and spontaneously hypertensive rats.

9 ertensive rats, with a greater inhibition in spontaneously hypertensive rats.

10 mean arterial pressure (MAP) in anesthetized spontaneously hypertensive rats.

11 voke a required restoration of MAP levels in spontaneously hypertensive rats.

12 prehypertensive and 10-week-old hypertensive spontaneously hypertensive rats.

13 ificantly upregulated compared with sham-RDN spontaneously hypertensive rats.

14 pressure in response to vasoconstrictors in spontaneously hypertensive rats.

15 eported for insulin resistance and BP in the spontaneously hypertensive rats.

16 antagonist SC51322 reduced blood pressure in spontaneously hypertensive rats.

17 dependent on the carotid body (CB) input in spontaneously hypertensive rat, a model that also exhibi

18 lly, AM404 reduced hyperactivity in juvenile spontaneously hypertensive rats, a putative model of att

19 n distal middle cerebral artery occlusion in spontaneously hypertensive rats, a strain representative

20 In contrast, in spontaneously hypertensive rats, administration of C-21

21 blood pressure lasting for four-six hours in spontaneously hypertensive rats after a single dose of T

22 al tumor incidence and origin in a cohort of spontaneously hypertensive rats aged 20-24 months (SHRs;

23 nd we have described disordered breathing in spontaneously hypertensive rats, an animal model of gene

24 ntegrity and wall pathology were examined in spontaneously hypertensive rat and chronic angiotensin I

25 ntegrity and wall pathology were examined in spontaneously hypertensive rat and chronic angiotensin I

26 lodalton protein isolated from hypertrophied spontaneously hypertensive rat and dilated cardiomyopath

27 1a(+) immune cells are dominant in the (SHR) spontaneously hypertensive rat and expand in response to

28 duced a long-term antihypertensive effect in spontaneously hypertensive rats and antifibrotic effects

29 DDR2-integrin-beta1 link was also evident in spontaneously hypertensive rats and DDR2-knockout mice.

30 , purified, and sequenced from the hearts of spontaneously hypertensive rats and dilated cardiomyopat

31 ertensive rats (BHR), the first offspring of spontaneously hypertensive rats and normotensive Wistar-

32 ivation, attenuated hypertension in both the spontaneously hypertensive rats and the chronic angioten

33 Fetal hepatocytes were harvested from spontaneously hypertensive rats and transplanted into re

34 manner, with similar levels of inhibition in spontaneously hypertensive rats and Wistar-Kyoto rats; m

35 ion-induced damage than is the kidney of the spontaneously hypertensive rat, and (b) establish the fe

36 enase and the development of hypertension in spontaneously hypertensive rats, and 2) a relationship b

37 sympathetic stellate ganglion of Wistar and spontaneously hypertensive rats, and human-induced pluri

38 n myotrophin-induced cardiac hypertrophy, in spontaneously hypertensive rats, and in dilated cardiomy

39 After BM ablation in spontaneously hypertensive rats, and reconstitution with

40 This study explored the spontaneously hypertensive rat as an animal model of pul

41 antly larger increases in MAP and HR in male spontaneously hypertensive rats as compared to normotens

42 ide hydrolase (sEH) reduce blood pressure in spontaneously hypertensive rats as well as the findings

43 asting (~6 hours) antihypertensive effect in spontaneously hypertensive rats, associated with a signi

44 ide antihypertensive effect was evaluated in spontaneously hypertensive rats at an oral dose of 10 mg

45 himeric Wistar-Kyoto rats reconstituted with spontaneously hypertensive rat BM.

46 with blood pressure returning to baseline in spontaneously hypertensive rats by three days after trea

47 The spontaneously hypertensive rat can be a model of pulmona

48 upregulated or downregulated in 12-week-old spontaneously hypertensive rats compared to normotensive

49 mmunohistochemical staining of the aortae of spontaneously hypertensive rats demonstrated strong corr

50 Wistar Kyoto rat BM, the resultant chimeric spontaneously hypertensive rats displayed significant re

51 l ester was given by daily s.c. injection to spontaneously hypertensive rats exposed to filtered air

52 The right MCA was occluded in spontaneously hypertensive rats for 0, 60 and 120 min.

53 (AT(1)R-AS) in a retroviral vector prevents spontaneously hypertensive rats from developing hyperten

54 (ii) Spontaneously hypertensive rats have more orexin neurons

55 in, a hypertrophic activator identified from spontaneously hypertensive rat heart and cardiomyopathic

56 and myocardial microstructure of healthy and spontaneously hypertensive rat hearts at the ages of 12

57 recording in freely moving normotensive and spontaneously hypertensive rats, high-resolution echocar

58 an animal model of stroke, the stroke-prone spontaneously hypertensive rat, implicated the gene enco

59 tolic blood pressure (Delta=48+/-5 mm Hg) in spontaneously hypertensive rats, indicating that SNX5 de

60 d 20-HETE formation in renal microsomes from spontaneously hypertensive rats, it has been proposed th

61 In older spontaneously hypertensive rats, it reduced left ventric

62 the cortex and outer medulla of 1-4-week-old spontaneously hypertensive rat kidneys relative to the c

63 s chronic hypertension develops in the young spontaneously hypertensive rat, medullary Na,K-ATPase ac

64 In spontaneously hypertensive rats, MGR and HDCF effectivel

65 ins long-term blood pressure regulation in a spontaneously hypertensive rat model over 4 weeks.

66 We have used a spontaneously hypertensive rat model to investigate the

67 either the overload of heart failure (or the spontaneously hypertensive rat model) or the profound un

68 nder Dox-induced cardiotoxic conditions in a spontaneously hypertensive rat model.

69 efective in prehypertensive and hypertensive spontaneously hypertensive rats, presenting a potential

70 rom normal (Wistar Kyoto) and hypertrophied (spontaneously hypertensive rat) rats was investigated by

71 Spontaneously hypertensive rats received either bilatera

72 f the cationic peptides (200mg/kgbodywt.) to spontaneously hypertensive rats resulted in a more rapid

73 Elevated Chga occurs in spontaneously hypertensive rat (SHR) adrenal glands and

74 oad LVH using 2 standard rat models: (1) the spontaneously hypertensive rat (SHR) and (2) aortic band

75 The spontaneously hypertensive rat (SHR) and its normotensiv

76 xygen consumption have been described in the spontaneously hypertensive rat (SHR) and may contribute

77 binant inbred (RI) strains, derived from the spontaneously hypertensive rat (SHR) and normotensive Br

78 organism, mated it with the stroke-resistant spontaneously hypertensive rat (SHR) and performed a gen

79 quantify metabolic substrate shifts with the spontaneously hypertensive rat (SHR) as a model of left

80 for this heightened action of Ang II in the spontaneously hypertensive rat (SHR) brain neurons.

81 regulatory brain areas, was increased in the spontaneously hypertensive rat (SHR) compared to the Wis

82 in was significantly enhanced in the RVLM of spontaneously hypertensive rat (SHR) compared with normo

83 rent at physiological membrane potentials in spontaneously hypertensive rat (SHR) compared with Wista

84 The adult spontaneously hypertensive rat (SHR) has been shown to e

85 The spontaneously hypertensive rat (SHR) has been suggested

86 The spontaneously hypertensive rat (SHR) has been widely use

87 IL-17 family in genetic hypertension in the spontaneously hypertensive rat (SHR) has not been invest

88 factor that stimulates myocytes growth, from spontaneously hypertensive rat (SHR) heart and patients

89 The spontaneously hypertensive rat (SHR) is a model of these

90 In contrast, the spontaneously hypertensive rat (SHR) is highly resistant

91 The spontaneously hypertensive rat (SHR) is insulin resistan

92 The spontaneously hypertensive rat (SHR) is often used as a

93 P-catalyzed EET formation was altered in the spontaneously hypertensive rat (SHR) kidney.

94 Using the spontaneously hypertensive rat (SHR) model of ADHD, we r

95 In the spontaneously hypertensive rat (SHR) model of genetic hy

96 system to safely ablate the CB in vivo in a spontaneously hypertensive rat (SHR) model of hypertensi

97 tatively the cTnI phosphorylation changes in spontaneously hypertensive rat (SHR) model of hypertensi

98 n pre- and early-onset hypertension from the spontaneously hypertensive rat (SHR) model, which repres

99 chronic cardiac injury was evaluated in the spontaneously hypertensive rat (SHR) model.

100 robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model.

101 We tested the hypothesis that in spontaneously hypertensive rat (SHR) NO produced central

102 fold in renal cortical S9 fractions from the spontaneously hypertensive rat (SHR) relative to the nor

103 middle cerebral artery occlusion (tMCAO) in spontaneously hypertensive rat (SHR) resulted in signifi

104 ng clinically relevant cyclic stretch and in spontaneously hypertensive rat (SHR) retina.

105 The spontaneously hypertensive rat (SHR) strain exists in li

106 Previous studies in the spontaneously hypertensive rat (SHR) support a role for

107 Previous studies in the spontaneously hypertensive rat (SHR) support a role for

108 For this study, we hypothesized that spontaneously hypertensive rat (SHR) vessels should have

109 P expression is significantly reduced in the spontaneously hypertensive rat (SHR) which could contrib

110 and SHR.WKY-Sa) derived from a cross of the spontaneously hypertensive rat (SHR) with the Wistar-Kyo

111 aintenance of elevated blood pressure in the spontaneously hypertensive rat (SHR), a genetic model fo

112 nd maintenance of high blood pressure in the spontaneously hypertensive rat (SHR), a model of primary

113 n pre- and early-onset hypertension from the spontaneously hypertensive rat (SHR), a model that resem

114 The spontaneously hypertensive rat (SHR), a putative animal

115 The spontaneously hypertensive rat (SHR), a widely used anim

116 vents the development of hypertension in the spontaneously hypertensive rat (SHR), an animal model fo

117 In the spontaneously hypertensive rat (SHR), in spite of normal

118 rtriglyceridemia and hyperinsulinemia of the spontaneously hypertensive rat (SHR).

119 d to be increased in proximal tubules of the spontaneously hypertensive rat (SHR).

120 when administered orally at 10 mg/kg to the spontaneously hypertensive rat (SHR).

121 ADHD as well as an animal model of ADHD, the spontaneously hypertensive rat (SHR).

122 olic heart failure (HF) were examined in the spontaneously hypertensive rat (SHR).

123 ain-specific translational regulation in the spontaneously hypertensive rat (SHR/Ola).

124 Furthermore, antihypertensive effects in spontaneously hypertensive rats (SHR) also revealed that

125 the susceptibility of 5- to 6-month-old male spontaneously hypertensive rats (SHR) and age/sex-matche

126 The development of hypertension in spontaneously hypertensive rats (SHR) and hyperactive vo

127 edback (TGF) activity in 7-wk-old, euvolemic spontaneously hypertensive rats (SHR) and in Wistar-Kyot

128 ne rats (SHR-SP) have more brain injury than spontaneously hypertensive rats (SHR) and normotensive c

129 Spontaneously hypertensive rats (SHR) and normotensive W

130 smutase (ECSOD) reduces arterial pressure in spontaneously hypertensive rats (SHR) and whether its he

131 ght neurobehavioral tests were performed for Spontaneously Hypertensive rats (SHR) and Wistar Kyoto r

132 Cell counts were also made in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (

133 Spontaneously hypertensive rats (SHR) are the most widel

134 myosin light chain kinase (smMLCK) by using spontaneously hypertensive rats (SHR) as an experimental

135 solated carotid body glomus cells from young spontaneously hypertensive rats (SHR) before the onset o

136 mined in DHI, Losartan, and placebo- treated Spontaneously Hypertensive Rats (SHR) by both noninvasiv

137 Ischemic tolerance was induced in spontaneously hypertensive rats (SHR) by injection of a

138 d renal sympathetic nerve activity (RSNA) in spontaneously hypertensive rats (SHR) compared to normot

139 red in distal mesenteric arteries from adult spontaneously hypertensive rats (SHR) compared with norm

140 ion showed greater levels of PRR mRNA in the spontaneously hypertensive rats (SHR) compared with norm

141 gher in the paraventricular nucleus (PVN) of spontaneously hypertensive rats (SHR) compared with thei

142 uscle cells (ASMCs) obtained from adult male spontaneously hypertensive rats (SHR) compared with thos

143 After a period of stable hypertrophy, male spontaneously hypertensive rats (SHR) develop heart fail

144 wever, AMPAR-EPSCs of labeled PVN neurons in spontaneously hypertensive rats (SHR) displayed inward r

145 Experiments used spontaneously hypertensive rats (SHR) during the early d

146 Recent evidence in vivo indicates that spontaneously hypertensive rats (SHR) exhibit an increas

147 We used Spontaneously Hypertensive Rats (SHR) exhibiting many fe

148 Spontaneously hypertensive rats (SHR) had a 90 min middl

149 Spontaneously hypertensive rats (SHR) have an activated

150 nsive strain rats having the highest and the spontaneously hypertensive rats (SHR) having the lowest

151 emitted at a higher pitch by male Wistar and spontaneously hypertensive rats (SHR) in an intensified

152 Spontaneously hypertensive rats (SHR) respond with exagg

153 ied the metabolic effects of pioglitazone in spontaneously hypertensive rats (SHR) that harbor a dele

154 d Ang II-induced inhibition of baroreflex in spontaneously hypertensive rats (SHR) versus WKY rats.

155 Spontaneously hypertensive rats (SHR) were compared to n

156 Male 20-week-old spontaneously hypertensive rats (SHR) were divided into

157 Groups of spontaneously hypertensive rats (SHR) were given 1 mg/kg

158 Spontaneously hypertensive rats (SHR) were treated with

159 al behavior were examined in male and female spontaneously hypertensive rats (SHR), a commonly used a

160 evation of peripheral vascular resistance in spontaneously hypertensive rats (SHR), a glucocorticoid-

161 rted that subjects with ADHD as well as male spontaneously hypertensive rats (SHR), a strain that is

162 KY) rats with borderline hypertension and in spontaneously hypertensive rats (SHR), a widely used gen

163 ng in the PVN in sympathetic overactivity in spontaneously hypertensive rats (SHR), a widely used gen

164 responses are impaired in arterioles of male spontaneously hypertensive rats (SHR), but they are stil

165 In spontaneously hypertensive rats (SHR), cannabinoid-1 rec

166 In spontaneously hypertensive rats (SHR), high NaCl diets i

167 us injection of AdECSOD(R213G) or AdECSOD in spontaneously hypertensive rats (SHR), immunostaining de

168 t regressing left ventricular hypertrophy in spontaneously hypertensive rats (SHR), possibly because

169 ts and increases smMLCK promoter activity in spontaneously hypertensive rats (SHR).

170 II (Ang II) and associated tissue injury in spontaneously hypertensive rats (SHR).

171 tail artery from normotensive rats (NTR) or spontaneously hypertensive rats (SHR).

172 lar smooth muscle cells (VSMC) isolated from spontaneously hypertensive rats (SHR).

173 Sprague-Dawley (SD), Wistar-Kyoto (WKY), and spontaneously hypertensive rats (SHR).

174 in normotensive (Wistar Kyoto rat, WKY) and spontaneously hypertensive rats (SHR).

175 nteracted the development of hypertension in spontaneously hypertensive rats (SHR).

176 s been shown to induce ischemic tolerance in spontaneously hypertensive rats (SHR).

177 of normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR).

178 st the ability to suppress blood pressure in spontaneously hypertensive rats (SHR).

179 follow the development of chronic changes in spontaneously hypertensive rats (SHR).

180 nsive effect of amaranth protein/peptides on spontaneously hypertensive rats (SHR).

181 12a2 results from altered DNA methylation in spontaneously hypertensive rats (SHR).

182 ment linked to the hypertensive phenotype in spontaneously hypertensive rats (SHR).

183 inflammation (SI; at a septic-like model) in spontaneously hypertensive rats (SHR).

184 inea pigs; and (3) vasoregulatory effects in spontaneously hypertensive rats (SHR).

185 in a rat model of chronic hypertension, the spontaneously hypertensive rats (SHR).

186 y on BP, cardiac function, and remodeling in spontaneously hypertensive rats (SHR).

187 intain resting sympathetic vasomotor tone in spontaneously hypertensive rats (SHR).

188 sartan on the progression of renal injury in spontaneously hypertensive rats (SHR).

189 ransplanted into unilaterally nephrectomized spontaneously hypertensive rats (SHR-RT1.N strain) that

190 in response to increased flow, stroke-prone spontaneously hypertensive rats (SHR-SP) exhibited a sma

191 Female spontaneously hypertensive rats (SHR; age, 4 months) wer

192 onducted on 4- to 5-week-old prehypertensive spontaneously hypertensive rats (SHRs) and age-matched n

193 N-mediated actions of Ang II are enhanced in spontaneously hypertensive rats (SHRs) and contribute to

194 aimed to observe effects of BSJYD on LVH in spontaneously hypertensive rats (SHRs) and explore its p

195 sparks in ventricular cells from 6-month-old spontaneously hypertensive rats (SHRs) and from age- and

196 eurons isolated from the stellate ganglia of spontaneously hypertensive rats (SHRs) and their normote

197 corded in spinally projecting PVN neurons in spontaneously hypertensive rats (SHRs) and Wistar-Kyoto

198 bers from normotensive Wistar-Kyoto rats and spontaneously hypertensive rats (SHRs) by cytofluorimetr

199 In pre-hypertensive (PH) and adult spontaneously hypertensive rats (SHRs) carotid body type

200 ed hypoxia-related proteins in the testes of spontaneously hypertensive rats (SHRs) compared to Wista

201 n increased level in the PVN tissue in adult spontaneously hypertensive rats (SHRs) compared with age

202 ker, candesartan, was orally administered to spontaneously hypertensive rats (SHRs) for 40 days, foll

203 a larger amplitude and shorter decay time in spontaneously hypertensive rats (SHRs) than in Wistar-Ky

204 Two cohorts of Spontaneously Hypertensive Rats (SHRs) were exposed to 1

205 Immune-competent spontaneously hypertensive rats (SHRs) were implanted wi

206 vior and social interaction were examined in spontaneously hypertensive rats (SHRs), a commonly used

207 tivity of spinally projecting PVN neurons in spontaneously hypertensive rats (SHRs), but not in normo

208 In spontaneously hypertensive rats (SHRs), high ABP is asso

209 not different between Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHRs), renal ETBR phosp

210 These effects are exaggerated in spontaneously hypertensive rats (SHRs), resulting in an

211 study, we examined conditioned inhibition in spontaneously hypertensive rats (SHRs), the most well-va

212 labelled spinally projecting PVN neurons in spontaneously hypertensive rats (SHRs).

213 dritic spine density are increased in NTS of spontaneously hypertensive rats (SHRs).

214 ex function in Wistar-Kyoto (WKY) but not in spontaneously hypertensive rats (SHRs).

215 ta(1)-ARs as well as lower blood pressure in spontaneously hypertensive rats (SHRs).

216 ist improves the baroreceptor reflex gain in spontaneously hypertensive rats (SHRs).

217 tivity of PVN presympathetic neurons in male spontaneously hypertensive rats (SHRs).

218 kDa (LFH <3 kDa) were orally administered to spontaneously hypertensive rats (SHRs).

219 ing shift that diminishes GABA inhibition in spontaneously hypertensive rats (SHRs).

220 VN neurons and sympathetic vasomotor tone in spontaneously hypertensive rats (SHRs).

221 on NTS baroreceptor second-order neurons in spontaneously hypertensive rats (SHRs).

222 eart rate (HR), observed in the stroke-prone spontaneously hypertensive rat (SHRSP(HD)), is a primary

223 We used the stroke-prone spontaneously hypertensive rat (SHRSP) as a model organi

224 The stroke-prone spontaneously hypertensive rat (SHRSP) is a genetically

225 icroangiopathy in salt-loaded, stroke-prone, spontaneously hypertensive rats (SHRSP) without controll

226 in male and female 16 week old stroke prone spontaneously hypertensive rats (SHRSP).

227 e rats and transplanted into recipient adult spontaneously hypertensive rat spleens.

228 m channel blocker, SNX-111, was evaluated in spontaneously hypertensive rats subjected to 60 min of f

229 greater renal vasoconstriction in 7-wk-old, spontaneously hypertensive rats than in Wistar-Kyoto rat

230 Here, in ventricular myocytes from spontaneously hypertensive rats that develop heart failu

231 hesized that in hypertensive diabetic state (spontaneously hypertensive rat), the CB is sensitized by

232 izes the authors' recent experience with the spontaneously hypertensive rat, the best experimental mo

233 In the MCAO model, conducted in the spontaneously hypertensive rat, the more polar 3-hydroxy

234 In anesthetized spontaneously hypertensive rats, the middle cerebral art

235 After oral administration to spontaneously hypertensive rats, the S1P1 selective comp

236 e used an animal model of ischemic stroke in spontaneously hypertensive rats to determine whether or

237 Male spontaneously hypertensive rats underwent occlusion of t

238 blood pressure reduction in both normal and spontaneously hypertensive rats via interactions with th

239 The increase in blood pressure in spontaneously hypertensive rat was associated with gut p

240 ithelial cells derived from Wistar-Kyoto and spontaneously hypertensive rats were grown to confluency

241 RF-RDN (n=14) or sham-RDN (n=14) treatment, spontaneously hypertensive rats were subjected to 30 min

242 Halothane-anesthetized spontaneously hypertensive rats were subjected to middle

243 Spontaneously hypertensive rats were treated with 2, 3-d

244 Obese ZSF1 (Zucker fatty and spontaneously hypertensive) rats were randomized to stan

245 od pressure in the aorta-ligated rat and the spontaneously hypertensive rat when administered orally.

246 reflex-function curves is exaggerated in the spontaneously hypertensive rat where the cardiac compone

247 Five-day twice daily treatment of spontaneously hypertensive rats with TMinh-23 produced s

248 enteric resistance arteries of wild-type and spontaneously hypertensive rats, with a greater inhibiti