ライフサイエンスコーパス: sporulation

1 i-GMP) determines when Streptomyces initiate sporulation.

2 ess, which controls many genes essential for sporulation.

3 ain vegetative growth and prevent entry into sporulation.

4 s an inhibitor that blocks the initiation of sporulation.

5 pores, a process collectively referred to as sporulation.

6 including metabolism, biofilm formation, and sporulation.

7 n factor sigma(F), a hallmark for entry into sporulation.

8 hrose delayed spore germination and enhanced sporulation.

9 the enzyme is tetrameric during B. subtilis sporulation.

10 ce KinA can bypass the salt-imposed block in sporulation.

11 wall biogenesis during growth, division and sporulation.

12 rocesses: protein sorting to the vacuole and sporulation.

13 l division relative to the chromosome during sporulation.

14 a lytic transglycosylase (LT) essential for sporulation.

15 ating that CD1492 is a negative regulator of sporulation.

16 ertions that trigger premature initiation of sporulation.

17 y regulatory protein controlling clostridial sporulation.

18 ipate in cell-cell signaling pathways during sporulation.

19 multicellular fruiting body development, and sporulation.

20 switch from fermentation to respiration and sporulation.

21 pression to developmental transitions during sporulation.

22 uring mitosis, and if Boi1 is present during sporulation.

23 nd membrane fission during Bacillus subtilis sporulation.

24 ses are involved in their degradation during sporulation.

25 Mutations in the devTRS genes impair sporulation.

26 during the critical period of commitment to sporulation.

27 A cooperatively regulate genes important for sporulation.

28 the biofilm, even though sigma(B) represses sporulation.

29 on of the dev operon, which is important for sporulation.

30 iological functions ranging from motility to sporulation.

31 ch as energy regulation, transportation, and sporulation.

32 lus subtilis 168 and plays a key role in its sporulation.

33 teins in that neither is required for sexual sporulation.

34 lloprotease that cleaves Pro-sigma(K) during sporulation.

35 enes are employed for GABA generation during sporulation.

36 om DeltabsrA cultures also resulted in early sporulation.

37 aturation, but CcdA2 could still function in sporulation.

38 ted accumulation of Spo0A approximately P on sporulation.

39 al release of an EndoG homolog, Nuc1, during sporulation.

40 . subtilis cells, and stimulates B. subtilis sporulation.

41 rasites, which leads to meiotic division and sporulation.

42 erence resulted in chlorosis and reduced Pst sporulation.

43 n from aggregation to sporulation, or during sporulation.

44 t assemble in an orchestrated fashion during sporulation.

45 AbrB repression in regulating C. perfringens sporulation.

46 lon are translated at different times during sporulation.

47 ain under selective conditions that required sporulation.

48 evel of epsilon toxin production and repress sporulation.

49 enriched in genes involved with dormancy and sporulation.

50 the TCA cycle and lipid biosynthesis during sporulation.

51 ate stage of symptom expression and pathogen sporulation (168 hpi).

52 tional, and other signals that normally make sporulation a post-exponential-phase response.

53 he methyltransferase gene negatively impacts sporulation, a key step in C. difficile disease transmis

54 During the early stages of sporulation, a subpopulation of Bacillus subtilis cells

55 positive and negative signals, ensuring that sporulation, a time- and energy-consuming process that m

56 xplained by continuous selection to increase sporulation ability in young colonies.

57 Both sigma(B) and sporulation activity increase in a gradient, peaking at

58 influence or trigger chromosome segregation, sporulation, aerotaxis, and social behaviors, including

59 Bacterial sporulation allows starving cells to differentiate into

60 During sporulation, an asymmetrically-positioned septum generat

61 exists in a low-activity (pT) form early in sporulation and a high-activity (pT/pY) form later in th

62 onsistently underexpressed pathways included sporulation and amino acid biosynthesis, whereas up-regu

63 mental changes leading to biofilm formation, sporulation and competence.

64 lsed response allows cells to decide between sporulation and continued vegetative growth during each

65 rent study asked whether CodY also regulates sporulation and CPE production in SM101, a derivative of

66 ed strain recovered wild-type levels of both sporulation and CPE production.

67 wth, pigment and aerial mycelium production, sporulation and dimorphic transition to blastospore prod

68 the abrB gene in SM101 reduced the levels of sporulation and enterotoxin production, supporting the i

69 film formation, we found that RapP regulates sporulation and genetic competence as a result of its ab

70 oligopeptide permease that is essential for sporulation and genetic competence development, proved t

71 In this review, the regulation of the sporulation and germination pathways and the morphogenes

72 hese polyketides act as chemical triggers of sporulation and granulose accumulation in this strain.

73 s that are more resistant and have increased sporulation and host colonization capacity when glucose

74 w that disruption of the gene CD3668 reduces sporulation and increases toxin production and motility.

75 olved in the regulatory cascade of bacterial sporulation and inhibits the open complex formation due

76 ikingly, extra copies of septin CDC10 rescue sporulation and LEP localization in cells lacking Sma1,

77 DnfA is involved in asexual sporulation and polarized growth.

78 data indicate that CD1492 negatively affects sporulation and positively influences motility and virul

79 significantly stimulates biofilm-associated sporulation and production of an undefined brown pigment

80 chanisms of PHB contribution to B. anthracis sporulation and provide valuable insight into the metabo

81 protease to degrade SpoIVA, thereby halting sporulation and resulting in lysis of defective sporulat

82 ignificant since CPE is produced only during sporulation and since C. perfringens can sporulate in th

83 bromii strains possess a full complement of sporulation and spore germination genes and we demonstra

84 of differentiation such as those that allow sporulation and spore germination, (iii) contribution to

85 n of environmental conditions prompting cell sporulation and spores germination.

86 eRS is required in B. subtilis for efficient sporulation and suggests that editing by aminoacyl-tRNA

87 e newly forming species that are involved in sporulation and the metabolism of simple dietary sugars.

88 ve renamed this locus rstA, for regulator of sporulation and toxins.

89 rs serve a different function in controlling sporulation and virulence in C. difficile than in Bacill

90 discovery of new genes and novel pathways in sporulation and, combined with the recently completed nu

91 ng (S)-malate and ornithine, quorum sensing, sporulation, and cell wall remodeling, suggesting a glob

92 signal transduction, adhesion, conjugation, sporulation, and outer membrane protein folding.

93 aspects of the fungus, such as germination, sporulation, appressorial formation as well as its patho

94 on in which life stages such as motility and sporulation are conserved and lost as discrete units.

95 d targets determining the timing and mode of sporulation are genes involved in cell division and the

96 actors involved in cell wall remodelling and sporulation are the main drivers of adaptation in S. cer

97 ID nevertheless plays auxiliary roles during sporulation, as it enhances levels of the exosporium mor

98 Through targeted gene knock-outs, sporulation assays and microscopic investigations we fou

99 Cells begin committing to sporulation at 24-30 h poststarvation, but the mechanism

100 The same QTLs determined delayed sporulation at the seedling stage in laboratory experime

101 During sporulation, Bacillus subtilis divides around the nucleo

102 otypes such as virulence, host colonization, sporulation, biofilm formation, among others.

103 r lifestyle switch, e.g., between virulence, sporulation, biofilm formation, and cell division.

104 color, it is required for the late stages of sporulation, but precisely how it functions is unknown.

105 ictyostelium, did not affect Polysphondylium sporulation, but prevented encystation.

106 related with within-host growth and onset of sporulation, but total spore production is decoupled fro

107 We have reported that this complex acts in sporulation by accelerating the phosphorylation of the r

108 Sporulation by Bacillus subtilis is a cell density-depen

109 inase and was originally proposed to promote sporulation by directly phosphorylating Spo0A.

110 processes with population density including sporulation, cannibalism, biofilm formation and genetic

111 During Bacillus subtilis sporulation, chromosome copy number is reduced to two, a

112 R analysis clearly demonstrated that, during sporulation, codY transcript levels remained high in SM1

113 uding the bacterial developmental pathway to sporulation, competence, and protease secretion.

114 enes involved in cellular processes, such as sporulation, competence, virulence, biofilm formation, c

115 nant exposure time, germinant concentration, sporulation conditions, and spore heat activation, as pr

116 om weak vegetative growth to induced asexual sporulation (conidiation) along a decreasing phenazine g

117 (Delta) of rgsD results in enhanced asexual sporulation coupled with increased mRNA levels of key de

118 The sporulation defect ranged from 3-fold to 30-fold and was

119 anisms have been disabled have a synergistic sporulation defect suggesting that both localization fac

120 utants that are delayed in the initiation of sporulation, defective in membrane remodeling, and impai

121 ng PSM, but previous studies noted only mild sporulation defects upon septin mutation.

122 nt with exogenous fatty acids overcame these sporulation defects, highlighting the importance of the

123 entified 133 out of the 148 genes with known sporulation defects.

124 ys a critical role in growth, asexual/sexual sporulation, deoxynivalenol production and virulence in

125 f 79 amino acids within the meiosis-specific sporulation domain SPO22.

126 gest that the phosphorelay is tuned to favor sporulation during growth in gastrointestinal B. subtili

127 Sporulation during growth occurs because Spo0A is more a

128 ncentration of ten antimicrobial agents, the sporulation efficiency and the colony forming ability.

129 Suppressors that modestly increase sporulation efficiency at high salinity map to the codin

130 However, sporulation efficiency drastically decreases concomitant

131 However, the sporulation efficiency in this artificial two-component

132 lative to that in the parental strain, while sporulation efficiency is unaffected in the mutants.

133 0A regulon expression, and that reduction in sporulation efficiency results from the reversal of that

134 ulence factor expression, and a reduction in sporulation efficiency.

135 Meiotic cell divisions are coordinated with sporulation events to produce haploid spores.

136 5-HT reduces the expression of sporulation factors and membrane transporters in T. sang

137 wider SEDS (shape, elongation, division and sporulation) family have now emerged as a previously unk

138 of the SEDS (shape, elongation, division and sporulation) family of proteins, which have essential bu

139 ble alterations in cell wall composition and sporulation features.

140 nd subsequent development of mycelium and/or sporulation; fifthly, assessments were carried out over

141 rential regulation of many genes involved in sporulation, flagella synthesis, carbohydrate metabolism

142 rganization of the cellular landscape during sporulation, from two cells that lie side by side to the

143 ulation was arrested at stage 0, and the key sporulation gene spo0A was upregulated only in B-type ce

144 resulted in the earlier expression of early sporulation genes and increased sporulation in vitro.

145 BldD represses expression of sporulation genes during vegetative growth in a manner t

146 ng (Tn-seq) to assess whether there were any sporulation genes left to be discovered.

147 ral gene for the S-layer protein Sap and the sporulation genes spo0A, spo0B, and spo0F in B. anthraci

148 t target of BldD, which functions to repress sporulation genes, including whiG, ftsZ and ssgB, during

149 cutes revealed typically clostridial sets of sporulation genes.

150 nd was due to a delay in activation of early sporulation genes.

151 ficile and Bacillus subtilis at the level of sporulation, germination, and spore coat and exosporium

152 he mechanisms underlying PHB contribution to sporulation have not been defined.

153 tarvation persists and halting commitment to sporulation if nutrients reappear.

154 ith the transition from vegetative growth to sporulation in a complex developmental life cycle.

155 se of checkpoints that govern the entry into sporulation in B. subtilis and discuss how the use of re

156 ithin a cell structure that is a hallmark of sporulation in B. subtilis and other spore-forming Firmi

157 ese permeases are known to positively affect sporulation in Bacillus species through the import of sp

158 for signal transduction in the initiation of sporulation in Bacillus subtilis and in bacterial two-co

159 on septum near a randomly chosen pole during sporulation in Bacillus subtilis creates unequal sized d

160 bsrA) is important for appropriate timing of sporulation in Bacillus subtilis in that cells lacking 6

161 Sporulation in Bacillus subtilis is governed by a cascad

162 Entry into sporulation in Bacillus subtilis is governed by a phosph

163 During sporulation in Bacillus subtilis, germinant receptors as

164 During sporulation in Bacillus subtilis, the only convex (posit

165 cking in vivo basement layer assembly during sporulation in Bacillus subtilis.

166 e initiates and controls the early stages of sporulation in C. difficile are not highly conserved in

167 permeases, Opp and App, in the regulation of sporulation in C. difficile.

168 168 hpi, reflecting symptom development and sporulation in cultivar Viroflay, but not at 48 hpi.

169 Loss of AcrA and AcgA, both essential for sporulation in Dictyostelium, did not affect Polysphondy

170 (6)A methyltransferase, Ime4, in meiosis and sporulation in diploid strains is very well studied, but

171 robial redox metabolites are key signals for sporulation in filamentous fungi, which are communicated

172 e device in studying growth, germination and sporulation in Fusarium virguliforme that causes sudden

173 indicate that B. subtilis blocks entry into sporulation in high-salinity environments preventing com

174 udied were expressed in the forespore during sporulation in parallel with the associated GR operon, a

175 elae, which is capable of fairly synchronous sporulation in submerged growth conditions.

176 factor SigF controls late development during sporulation in the filamentous bacterium Streptomyces co

177 ion of early sporulation genes and increased sporulation in vitro.

178 plays a significant role in pathogenesis and sporulation in vivo.

179 ex biochemical diversification of LDs during sporulation in which Sfh3 and select other LD proteins r

180 hout engulfment suggests new roles for PG in sporulation, including a new model for how PG synthesis

181 t upon Septoria infection but reduced fungal sporulation indicating that TaR1 is key for prolonging t

182 hat deletion of CD1492 resulted in increased sporulation, indicating that CD1492 is a negative regula

183 y, both activities of Sae2 are important for sporulation, indicating that the processing of meiotic b

184 anscriptional profiling uncovered additional sporulation-induced genes required for successful spore

185 ur analysis also revealed that as many as 36 sporulation-induced genes with no previously reported mu

186 (F) in individual cells held under constant, sporulation-inducing conditions.

187 DNA is a potential target for development of sporulation inhibitors.

188 Sporulation initiates with an asymmetric cell division,

189 he nutritional status of the environment and sporulation initiation in C. difficile.

190 gh the phosphorelay is the limiting step for sporulation initiation in the gut strain.

191 Central to the decision of entering sporulation is a phosphorelay, through which sensor kina

192 The initial step of sporulation is asymmetric cell division, leading to a la

193 Sporulation is critical for C. perfringens type A food p

194 Others only sporulate, but if sporulation is disabled by heterozygosity at the IME1 lo

195 resistance in the harsh food environment and sporulation is essential for CPE production.

196 As sporulation is imperative to the successful transmission

197 The initiation of sporulation is known to be regulated through activation

198 indicates that there are conditions in which sporulation is lost or selected against.

199 ng multiple rounds of vegetative growth when sporulation is not required.

200 s provide further evidence that C. difficile sporulation is regulated differently from that of other

201 Endospore formation (sporulation) is a well conserved microbial developmental

202 During sporulation, it takes an average of 10.5 h for a conidio

203 we observe rapid and parallel losses of the sporulation life stage across species, induced by mutati

204 suggest that Opp and App indirectly inhibit sporulation, likely through the activities of the transc

205 produce cell-cycle coordinated pulses of the sporulation master regulator Spo0A approximately P.

206 ate supernatants from modified Duncan-Strong sporulation (MDS) medium cultures of three CPE-positive

207 ately 6.3 to 7.8, or at 4 degrees C in spent sporulation medium caused no significant changes in ribo

208 up to 30 days at 37 or 50 degrees C in spent sporulation medium degraded significant amounts of 3PGA

209 as some metabolism in spores stored in spent sporulation medium.

210 eir ploidy when grown on a glucose-rich "pre-sporulation" medium.

211 In Streptomyces, during sporulation, multiple Z rings are assembled and lead to

212 or partially suppress the phenotypes of > 25 sporulation mutants.

213 ole for the arrangement of Bacillus subtilis sporulation network genes on opposite sides of the chrom

214 We show that the arrangement of two sporulation network genes, one located close to the orig

215 unction of the conserved architecture of the sporulation network is controlling Spo0A activation dyna

216 This imbalance is detected by the sporulation network to produce cell-cycle coordinated pu

217 Furthermore, we find that B. subtilis sporulation observed prior to direct contact with P. chl

218 GRN differs strikingly from those governing sporulation of Bacillus and Streptomyces, suggesting tha

219 it activates or represses many genes during sporulation of Bacillus subtilis.

220 ial formation of complex fruiting bodies and sporulation of M. xanthus.

221 ey reduce mortality and also decrease fungal sporulation on dead aphids which may help protect nearby

222 jection assays, with eruption and subsequent sporulation on host cadavers greatly reduced in the muta

223 onSIX6 gene in Fon race 1 did not affect the sporulation or growth rate of the fungus but significant

224 ype, yet the mutants exhibited no changes in sporulation or spore resistance to heat.

225 ation, in the transition from aggregation to sporulation, or during sporulation.

226 For successful sporulation, oriC must be captured in the forespore.

227 ution of OM damage, increasing developmental sporulation outcomes of the combined population by allow

228 led that high salinity blocks entry into the sporulation pathway at a very early stage.

229 During CDI, C. difficile induces a sporulation pathway that produces more spores; these spo

230 , it has completely lost its activity in the sporulation pathway.

231 leads to all cell types exhibiting an early-sporulation phenotype.

232 Several mutants had novel sporulation phenotypes.

233 ng the penetrance of the ylbF, ymcA and yaaT sporulation phenotypes.

234 po0F approximately P, an intermediate of the sporulation phosphorelay system.

235 2-MIB production is an integral part of the sporulation process, completing the Streptomyces life cy

236 investigated in planta and fungal growth and sporulation production was measured in vitro.

237 mutant, and Cdc11 and Cdc12 fail to restore sporulation proficiency to spr3Delta/spr3Delta spr28Delt

238 opment may help maintain the fidelity of the sporulation program in the species.

239 ary deterioration and ultimately loss of the sporulation program.

240 Stage II sporulation protein D (SpoIID) is a lytic transglycosyla

241 Spo0J (stage 0 sporulation protein J, a member of the ParB superfamily)

242 o factors with limited similarity to the Rap sporulation proteins of other spore-forming bacteria.

243 gene expression is independent of additional sporulation proteins; vegetative cells engineered to div

244 Bacillus subtilis sporulation provides a dramatic example of intercompartm

245 Similar to other Rap proteins that control sporulation, Rap60 modulates phosphorylation of the tran

246 ces on fitness that may include an increased sporulation rate and qualitative differences in virulenc

247 ically degraded soon after expression during sporulation, rather than escaping the developing spore.

248 nitrogen regulation protein NT-NtrC, and the sporulation response regulator Spo0F.

249 iately trigger the activation of GerA during sporulation resulting in premature germination.

250 A) from the shape, elongation, division, and sporulation (SEDS) family to make up the core peptidogly

251 The shape, elongation, division and sporulation (SEDS) proteins are a highly conserved famil

252 ubiquitous Shape, Elongation, Division, and Sporulation (SEDS)-family proteins RodA and FtsW were sh

253 merase systems, shape, elongation, division, sporulation (SEDS)-family proteins working within the cy

254 During Bacillus subtilis sporulation, segregating sister chromosomes are anchored

255 n event in which the synthesis of ladders of sporulation septa convert multigenomic hyphae into chain

256 reptomyces dynamins specifically localize to sporulation septa in an FtsZ-dependent manner.

257 The sspA deletion mutant exhibits irregular sporulation septation and altered spore shape, suggestin

258 rowth, co-ordinating their expression during sporulation septation.

259 poIIQ is required to recruit SpoIIIAH to the sporulation septum on the mother cell side; however, the

260 alization microscopy in strains with a thick sporulation septum to investigate the architecture and f

261 in that is produced under the control of the sporulation sigma factor sigma(F) to create a negative f

262 ptomyces venezuelae through sequestering the sporulation sigma factor sigma(WhiG) and presents the cr

263 l analyses indicate that pzX co-forms during sporulation, so that upon the release of the spore to th

264 e have analyzed the regulation of the unique sporulation-specific diadenylate cyclase CdaS.

265 in regulating the autophosphorylation of the sporulation-specific kinase KinA, a novel activity for R

266 he absence of structural information for the sporulation-specific LT enzymes has hindered mechanistic

267 Fluorescence microscopy of sporulation-specific promoter fusions to gfp revealed th

268 t target for SigF, the gene sspA, encoding a sporulation-specific protein.

269 on in Bacillus species through the import of sporulation-specific quorum-sensing peptides.

270 acts in parallel with but distinct from the sporulation-specific RacA pathway of oriC placement, and

271 el anti-sigma (RsiG) to bind and sequester a sporulation-specific sigma factor (sigma(WhiG)).

272 IB synthases are under the direct control of sporulation-specific transcription factors, constraining

273 ion defect due to the decreased stability of sporulation-specific Z-rings, as demonstrated by kymogra

274 olventogensis (buk, ctf, aldh, adh, bcd) and sporulation (spo0A, sigE, sigma-70, bofA), cell motility

275 cilitates quantification of population-level sporulation states.

276 Sporulation studies have contributed a wealth of informa

277 logical problems (alternative sigma factors, sporulation, swarming, biofilm formation, stochastic cel

278 n of the dormant cell type called the spore (sporulation), the direct link between PHB accumulation a

279 During sporulation, the filamentous bacteria Streptomyces under

280 e programs include the initiation of meiotic sporulation, the formation of filamentous growth structu

281 A is a bifunctional protein that upregulates sporulation through an unidentified pathway and represse

282 at PHB deficiency impairs Bacillus anthracis sporulation through diminishing the energy status of the

283 gulated cell death maintains the fidelity of sporulation through selective removal of cells that misa

284 n function-from an ancestral role regulating sporulation to a derived role regulating biofilm formati

285 Despite the importance of sporulation to C. difficile pathogenesis, the molecular

286 asing sigma(B) expression shifts the peak of sporulation to the middle of the biofilm.

287 dynamics of spore germination, colonization, sporulation, toxin activity, and disease progression thr

288 in the M. xanthus chromosome did not impair sporulation under laboratory conditions.

289 Here, we visualize Bacillus subtilis sporulation using cryo-electron tomography coupled with

290 , it became apparent that CodY regulation of sporulation varies among different C. perfringens strain

291 lts suggest that Dictyostelium multicellular sporulation was a likely adaptation to a cold climate.

292 F-type cells's sporulation was arrested at stage 0, and the key sporula

293 k between PHB accumulation and efficiency of sporulation was observed in multiple studies.

294 tracellular carbon and energy source fueling sporulation was proposed several decades ago, the mechan

295 ofiling of these strains further showed that sporulation was related with strain-specific genomic cha

296 for SpoIIID and sigma(K) during C. difficile sporulation, we analyzed spoIIID and sigK mutants using

297 To assess the role of CdaS in sporulation, we assayed the germination of wild type and

298 o measure relative ATP concentrations during sporulation, we found that the MC ATP concentration rise

299 mutants that were defective in motility and sporulation were rescued by OME with healthy donors.

300 fungal mycelium growth, cell densities, and sporulation, which enhanced the disease symptoms of suga