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1 ng domain (MTBD) at the end of a coiled-coil stalk.
2 periplasmic ring complex (PRC), and central stalk.
3 exible hinge between F(1) and the peripheral stalk.
4 in II of the uL10 subunit of the ribosomal P-stalk.
5 positively charged sequences on the CD8beta stalk.
6 uding its recruiter SpmX, at the base of the stalk.
7 rst fusion intermediate state, the so-called stalk.
8 upled together by a central and a peripheral stalk.
9 iated with low peptidoglycan turnover in the stalk.
10 her lowers the total work required to form a stalk.
11 the AAA ring by a ~ 135 angstrom coiled-coil stalk.
12 of two rows of cells into a single-cell-wide stalk.
13 subunits that dimerize through a coiled-coil stalk.
14 ntain persistent spores on top of a cellular stalk.
15 ane cap (OMC), a periplasmic ring (PR) and a stalk.
16 specific morphotype of Alphaproteobacterial stalks.
17 X, define and constrain PG synthesis to form stalks?
19 g tail, a coiled-coil central stalk (central stalk), a neck, and two identical C-terminal motor domai
20 1 and show how it promotes assembly of the P stalk, a critical element for recruitment of GTPases tha
21 he 584 kDa protein, comprising an N-terminal stalk, a dynein-like core with six ATPase units, and a m
22 is, and tshbetab cells near to the pituitary stalk, a location comparable to the pars tuberalis TSH c
24 at protecting against H1N1 infection than HA stalk Abs.IMPORTANCE Abs targeting the HA head of influe
27 articles can induce the formation of a lipid stalk and also drive its expansion into a fusion pore up
29 no correlation (postvaccination) between H1/stalk and HAI antibody responses, whereas a strong corre
30 no correlation (post-vaccination) between H1/stalk and HAI antibody responses, whereas a strong corre
31 extracellular portion of CD23, including the stalk and head domain; 1 variant was identical with the
32 pression upregulated in the Foxg1(-/-) optic stalk and hypothesized that, similar to what is observed
33 the destabilization of proteins in the 60S P-stalk and in the 40S beak, two binding regions of the eu
36 ses, specifically those in the hemagglutinin stalk and neuraminidase, are currently being developed(3
39 P21 but did not observe differences between stalk and swelling subcompartments in the mature calyx.
40 ace of KIF1C motor domain interacts with its stalk and that these autoinhibitory interactions are rel
41 und that the morphology of the optic cup and stalk and the closure of the optic fissure were substant
43 omposition of the peptidoglycan cell wall of stalks and cell bodies and identified key differences in
45 the peptidyl transferase center, the uL7/12 stalk, and 30S contact sites all show severe assembly de
46 aining of cells in the bk4 mutant leaves and stalk, and deformation of vascular bundles in the stalk
47 the human mitoribosome, including the L7/L12 stalk, and eight structures of its functional complexes
49 diated by sliding of the coiled-coils of the stalk, and that coordinated conformational changes of dy
50 ead of the infecting virus, to the conserved stalk, and to a broad chronological range of H3s consist
51 pment of membrane proximity, nucleation of a stalk, and triggered expansion of the fusion pore, here
55 hould consider including and evaluating anti-stalk antibodies as part of a multi-faceted strategy rat
56 tant consideration since broadly reactive HA stalk antibodies can protect against infection, and univ
57 radoxically, these heterosubtypic-boosted HA stalk antibodies do not bind efficiently to the boosting
59 s later in life since these viruses boost HA stalk antibodies that do not bind efficiently to the boo
60 vaccine regimens induced detectable anti-H1 stalk antibody (2.2-5.6 times induction over baseline),
61 ting NA, hemagglutination inhibiting, and HA stalk antibody levels and influenza viral shedding and d
62 results demonstrate that an individual's HA stalk antibody response is dependent on the specific sub
64 on inhibition, neuraminidase inhibition, and stalk antibody titers; peripheral blood leukocyte host g
66 h strong "immunological imprints" against HA stalk antigens first encountered during primary influenz
67 of this study suggest that a monoclonal anti-stalk approach to prevent or treat influenza infection m
68 Because the length and angle of the dynein stalk are fully conserved among species, our findings pr
70 the previous observation that C. crescentus stalks are lysozyme-resistant, we compared the compositi
71 ays an economic role in the countryside were stalks are produced mainly for human consumption without
73 lity and reinforce the notion of the central stalk as a key mechanical determinant of kinesin-14 moti
74 mmunity toward the more conserved HA stem or stalk as a means of broadening protective antibody respo
78 rastically lower the free energy of both the stalk barrier and metastable stalk, which is not trivial
79 have little effect on the free energy of the stalk barrier, likely because of its single molecular na
81 chamber termini and the morphogenesis of the stalk between adjacent egg chambers, which develops thro
83 ared the effectiveness of hemagglutinin (HA) stalk-binding bNAbs administered through the airway (int
84 c compounds (WSOCs) were extracted from corn stalk biochar produced at increasing pyrolysis temperatu
85 onferred resistance to some of the potent HA stalk broadly neutralizing monoclonal antibodies (bNAbs)
86 ated kinesin-1 KIF5B-560, which contains the stalk but not the cargo-binding and autoregulatory regio
87 te-stipitate fruiting bodies (with a cap and stalk), but the group also contains crust-like resupinat
88 Here we show that immune pressure on the HA stalk can lead to expansion of escape mutant viruses in
90 -related activities, including expression of stalk-cell markers and cell proliferation, consistent wi
91 sprouting angiogenesis, endothelial tip and stalk cells coordinately remodel their cell-cell junctio
92 icle cell polarisation, as both follicle and stalk cells localise polarity factors correctly, despite
94 routs revealed that mainly leader cells, not stalk cells, exert contractile forces on the surrounding
97 rol of available CcrM in progeny swarmer and stalked cells serves to protect the hemimethylated state
99 rotubule-binding tail, a coiled-coil central stalk (central stalk), a neck, and two identical C-termi
102 e that LOXL2 has a rod-like structure with a stalk composed of the SRCR domains and the catalytic dom
104 pened during transcription initiation in the stalk-containing RNAPs, including archaeal and eukaryoti
105 rs during translation, we propose that the P-stalk could link GCN2 activation to translational stress
106 of a monoclonal antibody that targets the HA stalk (CR6261) in a H1N1pdm09 healthy volunteer human ch
108 stator, and how the action of the peripheral stalk damps the side-to-side rocking motions that occur
109 bk4 plants displayed a reduction in average stalk diameter and mechanical strength, dwarf stature, s
110 oss accessions, was positively correlated to stalk diameter and plant height, but negatively correlat
112 lyzed antibody responses to H1 hemagglutinin stalk domain (H1/stalk) following trivalent influenza in
114 vivo The purified WT CCHFV N protein and the stalk domain also recognize the vRNA panhandle of hazara
115 ich refocuses the immune response toward the stalk domain and the conserved neuraminidase, is current
117 adly cross-reactive antibodies targeting the stalk domain of group 1 haemagglutinin-expressing influe
123 , here we investigated whether extending the stalk domain of the NA could render it more immunogenic
125 rate that, in the mouse model, extending the stalk domain of the NA protein can enhance its immunogen
126 iruses encoding amino acid changes in the HA stalk domain replicated well in vitro, and viruses incor
127 rotein has a distant RNA-binding site in the stalk domain that specifically recognizes the vRNA panha
128 also had the unique Y66D substitution in the stalk domain, where 66Y was highly conserved in N1 NAs.
129 suggests that conformational changes in the stalk domain-triggered by substrate binding at the dista
137 lysed antibody responses to H1 hemagglutinin stalk-domain (H1/stalk) following trivalent influenza in
140 s in the G receptor binding and F-activating stalk domains, providing insights into the pathway of re
144 sis is tied to its dimorphic life cycle, and stalk elongation is regulated by phosphate availability.
145 We determined that ldtD is dispensable for stalk elongation; rather, stalk LD-transpeptidation refl
146 rmed an RNA-seq screen, identifying tip- and stalk-enriched gene sets in the developing collecting du
147 dy BDBV223, alone and complexed with its GP2 stalk epitope, an interesting site for therapeutic/vacci
149 t the possible emergence of viruses carrying stalk escape mutation(s) under sufficient immune pressur
151 vated viruses expressing wild-type NA or the stalk-extended NA variants were used to vaccinate mice.
155 sponses to H1 hemagglutinin stalk-domain (H1/stalk) following trivalent influenza inactivated vaccine
156 sponses to H1 hemagglutinin stalk domain (H1/stalk) following trivalent influenza inactivated vaccine
159 sequential mechanisms, one occurring before stalk formation and one after, are consistent with our e
160 o increase lipid tail protrusion and promote stalk formation and then acts to engage the distal leafl
161 actofilins have diverse functions, from cell stalk formation in Caulobacter crescentus to chromosome
163 Membrane topology changes such as poration, stalk formation, and hemifusion rupture are essential to
171 e genotype, B73, representative of the stiff stalk heterotic group was recently updated (AGPv4) using
184 results demonstrate an essential role of the stalk in regulating motor activity and coupling conforma
185 important for understanding the role of the stalk in toxin recruitment to the sarcin/ricin loop and
186 branes and the formation of transient fusion stalks in molecular dynamics simulations and a coexistin
187 F(o) motor generates rotation of the central stalk, inducing conformational changes in the F(1) motor
189 metrically with McrB protomers and inserts a stalk into the pore of the ring, reminiscent of the gamm
190 a group of glia that migrates from the optic stalk into the third instar larval eye disc while the ph
191 Pase, the mechanical property of the central stalk is a key determinant of the rate of ATP turnover.
193 in of unknown function (DUF) adjacent to the stalk is identified as an ATPase domain that is essentia
194 is dispensable for stalk elongation; rather, stalk LD-transpeptidation reflects an aging process asso
196 solated from CHO cells, but not those with P-stalk lesions, stimulated GCN2-dependent eIF2alpha phosp
198 atenin target molecules in the optic cup and stalk may underlie the molecular and morphological defec
200 tural analysis to localize the origins of L1 stalk movement and to understand its dynamic interaction
201 ndard cell cultures, a destabilizing H1N1 HA stalk mutation greatly diminishes viral replication and
203 flavonoid abundance, maize varieties (stiff-stalk, nonstiff-stalk, tropical, sweet maize, and popcor
204 ds immediately surrounding the transmembrane stalk of a model protein allows conformational changes i
205 flexible polypeptide linker into the central stalk of full-length GiKIN14a nearly reduces its ATP hyd
210 es whose numbers of bouton-like swellings on stalks of the nerve terminals inversely correlate with r
213 erved region of influenza hemagglutinin (HA) stalk (or stem) has gained attention as a potent target
214 der, race, ethnicity, affected eye, subtype, stalk origin, complications on presentation, length of f
215 onstitution and properties of the peripheral stalk, part of the membrane extrinsic region of the stat
216 pimelic acid and D-alanine residues, whereas stalk peptidoglycan had more LD-transpeptidation (meso-d
219 Upon asymmetric cell division, swarmer and stalked progeny cells employ distinct mechanisms to cont
223 e C-terminal tails (CTTs) in the P1 and P2 P-stalk proteins are also essential for GCN2 activation.
224 Stx2a holotoxin also binds to the CTD of P stalk proteins because the ribosome-binding site is expo
232 he appreciated mechanism of protection by HA stalk-reactive antibodies is to inhibit HA stalk reconfi
233 otection mediated by influenza hemagglutinin stalk-reactive antibodies, i.e., inhibition of neuramini
234 rtant component of protection mediated by HA stalk-reactive antibodies.IMPORTANCE This study reports
235 lucelvax also induced similar frequencies of stalk-reactive antibody-secreting cells, showing that HA
238 A stalk-reactive antibodies is to inhibit HA stalk reconfiguration, blocking viral fusion and entry.
239 st, except for an amino acid exchange in the stalk region abolishing the N-linked glycosylation site;
240 served for the antiparallel CC of the dynein stalk region and the nuclear pore complex and suggests t
241 bdominant influenza virus hemagglutinin (HA) stalk region is a potential universal group-specific inf
244 peptide specifically targeted the conserved stalk region of H1 hemagglutinin and was effective again
245 one such target is the relatively conserved stalk region of the influenza A hemagglutinin (HA) surfa
247 gens, hemagglutinin (HA) (including head and stalk regions) and neuraminidase (NA), impact influenza
248 tic echinoderm-like plated theca, a muscular stalk reminiscent of the hemichordates and a pair of fee
250 , and deformation of vascular bundles in the stalk resulting in the loss of xylem and phloem tissues.
255 on in B cells was required for nearly all HA stalk-specific IgG2c antibodies and for durable neutrali
261 Overexpression of ZmCtl1 enhanced mechanical stalk strength without affecting plant stature, senescen
263 8) rotor ring or, separately, its peripheral stalk subunits b and oligomycin sensitive conferral prot
268 n a potential obstacle for the success of HA-stalk-targeting universal influenza vaccines-viral escap
269 elongation or shortening of the coiled-coil stalk that connects the motor to the microtubule control
272 N-terminal domains assemble into a cytosolic stalk that interacts with a microtubule-tethering protei
273 h the action of the tethered-peptide agonist stalk that is occluded within the GAIN domain in the hol
279 of-of-principle study to show that high anti-stalk titres can be induced by a rationally designed vac
280 exposes a latent capacity of the ribosome P-stalk to activate GCN2 in cells and help explain the eme
281 m the motor domain-the linker, buttress, and stalk-together regulate directional tension-sensing.
282 ance, maize varieties (stiff-stalk, nonstiff-stalk, tropical, sweet maize, and popcorn) showed differ
283 genes encoding components of the ribosome P-stalk, uL10 and P1, selectively attenuated GCN2-mediated
285 A dietary fibre prepared from sugarcane stalk was compared with psyllium husk and wheat dextrin.
287 By changing the length and angle of the stalk, we successfully reversed the motility towards the
288 to determine if Abs against the HA head and stalk were associated with protection from naturally acq
290 (RPLP1/2), which form the ancient ribosomal stalk, were discovered decades ago but their functions r
291 s attached to a thin, cell envelope-spanning stalk, whereas the F4 structure consists of the pilus do
292 rucial determinant of the free energy of the stalk, whereas the free-energy barrier changes only slig
293 connected by a 12-residue segment termed the stalk, which adopts a beta-strand conformation, instead
294 rgy of both the stalk barrier and metastable stalk, which is not trivially explained by molecular sha
295 ghter coupling distance to SVs elevate Pr in stalks, while smaller clusters with looser coupling dist