ライフサイエンスコーパス: stall

1 ce of UV-induced DNA lesions these complexes stall.

2 high-fidelity (HiFi) DNA polymerase (Pol) to stall.

3 cial mutations, its adaptive evolution would stall.

4 template in which reverse transcriptase (RT) stalls.

5 cular mechanisms that lead to these ribosome stalls.

6 and income inequality in the LAC region has stalled.

7 gardless of whether forks are replicating or stalled.

8 on malaria prevalence, however, has recently stalled.

9 ical relevance of this octameric M(pro) have stalled.

10 ission across Africa since 2000, progress is stalling.

11 t, but can be stabilized by replication fork stalling.

12 ted genome instability, and replication fork stalling.

13 ficial mutations contributed to evolutionary stalling.

14 The mechanosensing fibers strengthened upon stalling.

15 on downstream of endogenous and exogenous RF-stalling.

16 mations of the protein to enable sliding and stalling.

17 e persistent foci are not caused by physical stalling.

18 ion of Hel2 observed at a lower frequency of stalling.

19 k progression and increased replication fork stalling.

20 Since then, progress has stalled(2), and with insecticidal bednets losing efficac

21 T/s (or 102 kW/mol), and the stall torque: G(stall) ~ 3 k(B)T/rad (or 0.01 nN.nm/rad).

22 obust growth, the rise in US life expectancy stalled after 2010.

23 combining one WT and one D274A monomer also stalled after one electron was transferred in the WT hal

24 t full-length protein can still be made when stalling after the first N terminal helix has inserted i

25 However, stalling after the first three helices have exited the r

26 e such as, mechanistically, how growth cones stall and how axonal microtubules resist forces that wou

27 and only become targets if they subsequently stall and incur collisions.

28 expressome, whereas transcription inhibition stalled and rearranged it.

29 g, which can alter frameshifting in both the stalled and trailing ribosomes.

30 . pylori, is accompanied by replication fork stalling and can be observed also in primary cells deriv

31 the APP/PS1 genotype and a Hfd on capillary stalling and CBF.

32 ased amounts of spontaneous replication fork stalling and chromosomal aberrations, as well as fewer c

33 ecifically sensitive to the replication fork stalling and collapse caused by methyl methanesulfonate

34 during translation of mRNAs lead to ribosome stalling and collisions that trigger a series of quality

35 ated and then saturated in plagioclase after stalling and cooling in shallow-level chambers.

36 t studies indicate polyA runs cause ribosome stalling and frameshifting, triggering mRNA surveillance

37 prone bypass, whereas Gh or Sp causes strong stalling and only allows slow error-prone incorporation

38 ts within the translated mRNA cause ribosome stalling and reduce protein output.

39 d how they are implicated in transcriptional stalling and TC-NER in the cell remain unknown.

40 AL4-VVD movements, such as binding, sliding, stalling, and dissociation, was observed.

41 incomplete polypeptides produced by ribosome stalling, and Ltn1 mutation leads to neurodegeneration i

42 ations of mRNA in the A sites of all studied stall- and collision-inducing sequences.

43 ic Gram-negative bacterium Shigella flexneri stalls apoptosis by inhibiting effector caspase activity

44 translation process that cause ribosomes to stall as well as how cells use RQC to detect stalled rib

45 strated a complex I assembly defect, and the stalled assembly intermediates corroborate the role of N

46 ded C-Pro domains is mediated by recognizing stalled assembly of triple-helical domains or by direct

47 We found that most converging forks stall at a very late stage, indicating a role for additi

48 oadblocks to DNA replication, which tends to stall at these secondary structures.

49 complexes had completed promoter escape when stalled at +49.

50 ietic recovery, whereas recovery of controls stalled at 60%.

51 Ribo-T maturation is stalled at a late assembly stage.

52 -bound, multi-domain calcium-binding protein stalled at different points in translation with the nasc

53 complexes retained the GTFs when pol II was stalled at position +27 relative to the transcription st

54 the absence of Dcc, some ganglion cell axons stalled at the optic disc, whereas others perforated the

55 the normal size range derived from ribosomes stalled at the take-off codon.

56 In vivo, the AtaT2 activity induces ribosome stalling at all four glycyl codons but does not evoke a

57 Leading-strand polymerase stalling at DNA damage impairs replication fork progress

58 We demonstrate that DNA polymerase stalling at DNA structures induces error-prone DNA synth

59 t not SPRTN, protects replication forks from stalling at poly(ADP-ribose) polymerase 1 (PARP1)-DNA co

60 ides of the lesion, implying that polymerase stalling at the DPC activates SPRTN on both leading and

61 s indicate abnormal organelle morphology and stalling at the G2/M checkpoint in Mrp null cells.

62 oded by defective messenger RNAs and undergo stalling at the ribosome during translation.

63 tryptophan codons, along with their expected stalling at the tryptophan codon.

64 n heat stress, m(5) C loss leads to ribosome stalling at UUG triplets, the only codon translated by a

65 ll membrane buds at low resting tensions and stalls at a flat pit at high resting tensions.

66 repair is activated when a replication fork stalls at an ICL(2); this triggers monoubiquitination of

67 bserved when either Pol epsilon or Pol delta stalls at leading-strand damage, and do not require spec

68 es, disruption of endocytic trafficking, and stalled autophagic flux.

69 icularly Pol zeta alone showed a tendency to stall before the ICL, whereas Pol eta stalled just after

70 cortical astrocytes, and many striatal ones, stalled before entering transit-amplifying divisions.

71 ved through crystallization of cooling magma stalled beneath the crust.

72 One of the major polymerisation effects was stalling, but each of the individual proteins could inse

73 r these conditions does not result from fork stalling, but rather occurs at gaps formed by PrimPol re

74 e snapshots of how polymerase II (Pol II) is stalled by a nonbulky Gh lesion in a stepwise manner, in

75 Reducing capillary stalling by blocking neutrophil adhesion improved CBF an

76 No stalling by Rev1-Pol zeta directly past the ICL was obse

77 inhibitory response to serum starvation and stalls cell growth.

78 Stalled cells exhibited prolonged S-phase, were defectiv

79 Acute treatment with replication-stalling chemotherapeutics causes reversal of replicatio

80 es either promoted (PD0325901 and GW8510) or stalled (CHIR99021 and roscovitine) differentiation, res

81 significant differences in replication fork stalling, collapse, and DNA damage were detected between

82 t Dbr1 activity, HIV-1 reverse transcription stalls, consistent with blockage of viral reverse transc

83 fficient translation initiation allows these stall-containing endogenous mRNAs to escape collision-st

84 rent knowledge of how these different Pol II stalling contexts are distinguished by the cell, how the

85 equilibrium of the GTPase cycle towards the stalled 'dark state'.

86 partum care in SSA is critical to addressing stalling declines in maternal mortality and morbidity.

87 complementary drivers of network transition stalls developmental progression, emulating environmenta

88 ng-strand DNA synthesis, and the recovery of stalled DNA replication forks (RFs).

89 Defects in DNA repair and the protection of stalled DNA replication forks are thought to underlie th

90 ed to deleterious nucleolytic degradation of stalled DNA replication forks in a manner similar to tha

91 In bacteria, the restart of stalled DNA replication forks requires the DNA helicase

92 details in the interactions between PriA and stalled DNA replication forks with or without SSB.

93 mechanism that removes RNA polymerase (RNAP)-stalling DNA damage from the transcribed strand (TS) of

94 , POLE suppression leads to replication fork stalling, DNA damage, and a senescence-like state or cel

95 th synergistic increases in replication fork stalling, double-strand breaks, and apoptosis.

96 Intriguingly, we found that, when stalled due to interaction with the parental duplex, DNA

97 hich can lead to "parasite-induced migratory stalling" due to a positive feedback between increasing

98 Ribosomes stalled during translation must be rescued to replenish

99 tDNA deletions initiated by replication fork stalling during strand displacement mtDNA synthesis.

100 Stalling during translation triggers ribosome quality co

101 osomes to detect aberrant mRNAs selectively, stall elongation and trigger downstream quality control

102 disassembly of abnormally long-lived (i.e., stalled) elongation complexes.

103 es, change has slowed and on some indicators stalled entirely.

104 Here, we show that stalled Escherichia coli transcription elongation comple

105 The molecular mechanisms that drive these stalling events, however, are still unknown.

106 rection, termination sites, and fork pausing/stalling events.

107 en the wing is spread and operated in a deep-stall flight condition.

108 This force is higher than the stall force of a single Kip3 motor, supporting a collect

109 port gate, or by exerting equal and opposite stall force on it.

110 ce; it vanishes at a load equal to the motor stalling force and changes to a left-hand bias above tha

111 es of opposite polarity generates a backward stalling force that prevents entry into dendrites and th

112 SDE2 leads to impaired fork progression and stalled fork recovery, along with a failure to activate

113 BRCA1 may function upstream of BRCA2 in the stalled fork repair pathway.

114 ires SMARCAL1, suggesting that it depends on stalled fork reversal.

115 E3 ligase RFWD3 as an essential modulator of stalled fork stability in BRCA2-deficient cells and show

116 se uncoupling and establishment of prolonged stalled fork structures.

117 emoval is needed to restart DNA synthesis at stalled forks and promote survival following replication

118 le-stranded DNA-binding complex, localize at stalled forks and protect stalled forks from degradation

119 , and BRCA2 DNA repair associated (BRCA2) to stalled forks and that in their absence, nascent DNA str

120 ferase (HAT) that regulates the stability of stalled forks and the response to PARP inhibition in BRC

121 -CaMKK2-AMPK signaling cascade that protects stalled forks from degradation by phosphorylating and in

122 mplex, localize at stalled forks and protect stalled forks from degradation by the MRE11 nuclease.

123 exonuclease has been linked to protection of stalled forks from degradation.

124 Stalled forks in BRCA2-deficient cells accumulate phosph

125 ut it is unknown whether they activate HR at stalled forks or behind ongoing forks.

126 cA or RecA-independent template switching at stalled forks or postreplication gaps.

127 g a direct role of Nup1 in the relocation of stalled forks to NPCs and restriction of error-prone rec

128 At stalled forks, CMG removal results in fork breakage and

129 CST deficiency increases MRE11 binding to stalled forks, leading to nascent-strand degradation at

130 subset of BRCA2-deficient tumors, stabilize stalled forks, resulting in PARPi resistance in BRCA-def

131 ate that unlike the processing at HU-induced stalled forks, the function of the SNF2 translocases (SM

132 f RAD51-mediated homologous recombination at stalled forks.

133 64) to limit its association and activity at stalled forks.

134 11/EXO1 is required for their recruitment to stalled forks.

135 ing normal replication rates and stabilizing stalled forks.

136 lp maintain genomic integrity by stabilizing stalled forks.

137 Recently, stalling has also been linked to the activation of integ

138 However, such evolutionary stalling has not been empirically demonstrated, and it i

139 Explanations for the stall have focused on rising drug-related deaths.

140 alized TLS Pol is recruited and replaces the stalled HiFi Pol for lesion bypass.

141 F into one of three classes: open, close, or stall (i.e., no movement).

142 They suggest that T-cell lymphopoiesis might stall in individuals with short TL who are infected with

143 played reduced force output and inability to stall in optical trap assays but exhibited increased spe

144 lignancies where interneuron progenitors are stalled in differentiation by G34R/V mutations and malig

145 quiescent or entered another cell cycle but stalled in S-phase.

146 Neurons inhibited for Erk1/2 are stalled in the multipolar zone.

147 Our data indicate that ribosomes stalled in the polycysteine tract block mRNA structures

148 vel mRNA-induced mechanisms of translational stalling in eukaryotic ribosomes.

149 Thus, transient cell cycle stalling in G2 has key roles in wound healing but become

150 We show here that replication stalling in mitochondria leads to replication fork regre

151 ed to generate sufficient force to release a stall induced by the SecM stalling sequence and that rea

152 Remarkably, stalled initiation complexes remain in dynamic scrunchin

153 pared to controls, suggesting that capillary stalling is not a mechanistic link between a Hfd and inc

154 One way to prevent replication fork stalling is through the recruitment of specialized trans

155 ncy to stall before the ICL, whereas Pol eta stalled just after insertion across the ICL.

156 ion of aberrant mRNAs can cause ribosomes to stall, leading to collisions with trailing ribosomes.

157 sequences induce DNA polymerase slippage and stalling, leading to length and sequence variation.

158 , most genome-destabilizing replication fork stalling likely occurs because of proteins bound to the

159 s by stalling ribosomes and through ribosome stalling may also modulate the level of their mRNAs.

160 monstrated, and it is unclear to what extent stalling may limit the power of natural selection to imp

161 ns that result in irreversible transcription stalling might be important for TC-NER.

162 With cell cycle progression stalled, Muller glia undergo reactive gliosis, a patholo

163 nformation of switch I and II regions, which stalls multiple steps of the GTPase cycle and impairs bi

164 Fork slowing and stalling occur at structurally distinct lesions, are alw

165 The stalling of an abundant outer membrane lipoprotein, Lpp,

166 has remained controversial, resulting in the stalling of any therapeutic perspective.

167 retained within the Golgi, likely because of stalling of insulin-granule budding.

168 that has the potential to cause significant stalling of mtDNA replication.

169 ted with each other and imbalances result in stalling of neurite outgrowth.

170 The stalling of Pol eta directly past the ICL is attributed

171 y of nucleotide excision repair triggered by stalling of RNA polymerase at DNA lesions.

172 e report that FUS is necessary for efficient stalling of translation because deficient cells are refr

173 l protein B (SmpB) together rescue ribosomes stalled on a truncated mRNA and tag the nascent polypept

174 fB) releases nascent peptides from ribosomes stalled on mRNAs truncated at the A site, allowing ribos

175 tion factor eRF1, which recognizes ribosomes stalled on rare sense codons.

176 ing pathways of RNase H (RNH) nascent chains stalled on the prokaryotic ribosome in vitro We found th

177 played to apurinic/apyrimidinic 1 (APE1) and stalling on the fold to recruit activating factors, or O

178 Ser deprivation resulted in ribosomal stalling on two of the six Ser codons, TCC and TCT, and

179 gh numerous different obstacles cause Pol II stalling or arrest, the cell somehow distinguishes betwe

180 and take a limited number of steps prior to stalling or dissociation.

181 zones, as well as the poleward movement and stalling patterns of jet streams.

182 complex, but only one is bound productively, stalling Pchlide reduction in both active sites.

183 d Ala/Thr residues are added C terminally to stalled peptide, as shown during C-terminal Ala and Thr

184 These stalling points, which occur after the addition of three

185 If Ltn1 fails to ubiquitylate those stalled polypeptides or becomes limiting, CAT tails act

186 qc2 and the large ribosomal subunit elongate stalled polypeptides with carboxy-terminal alanine and t

187 Here we show that FUS can associate with stalled polyribosomes and that this association is sensi

188 B mutant cell death by possibly mistargeting stalled porins into the inner membrane.

189 Stalled protein synthesis produces defective nascent cha

190 ess, possibly by increasing replication fork stalling, providing a molecular mechanism for the deform

191 e discuss how replication forks are actively stalled, remodelled, processed, protected and restarted

192 ats form non-B DNA secondary structures that stall replication forks, activate the ATR checkpoint kin

193 DNA replication stress can stall replication forks, leading to genome instability.

194 merases may encounter DNA lesions, which can stall replication forks.

195 nts the endonuclease Mus81 from cleaving the stalled replication fork inappropriately.

196 lt-to-replicate' DNA regions, end resection, stalled replication fork processing, and mitochondrial g

197 Mechanistically, RAD52 binds to the stalled replication fork, promotes its occlusion and cou

198 knockdown in BRCA2-deficient cells protected stalled replication forks (RFs).

199 ntral FA pathway protein, FANCD2, locates to stalled replication forks and recruits homologous recomb

200 Degradation and collapse of stalled replication forks are main sources of genomic in

201 Without this response, stalled replication forks are not stabilized, and new or

202 Stalled replication forks can be restarted and repaired

203 RAD51 functions are also required to protect stalled replication forks from nucleolytic degradation d

204 l for telomere maintenance and resolution of stalled replication forks genome-wide.

205 he protection, processing, and remodeling of stalled replication forks in mammalian cells.

206 8 overexpression on hydroxyurea (HU)-induced stalled replication forks in the setting of BRCA1 defici

207 Stabilization of stalled replication forks is a prominent mechanism of PA

208 Stabilization of stalled replication forks prevents excessive fork revers

209 curately repair DNA double-strand breaks and stalled replication forks to maintain genome stability.

210 Moreover, in the absence of HAT1, stalled replication forks were unstable, and newly synth

211 ATRX and FANCD2 localize to stalled replication forks where they cooperate to recrui

212 and capacitate this ligase for DNA repair at stalled replication forks, facilitating mitotic progress

213 It has been proposed that at stalled replication forks, monoubiquitinated-FANCD2 serv

214 BRCA-deficient cells by acetylating H4K8 at stalled replication forks, which recruits MRE11 and EXO1

215 DNA digestion triggers CMG ubiquitylation at stalled replication forks.

216 essential for the functional maintenance of stalled replication forks.

217 d describes a new role for TIM in protecting stalled replication forks.

218 and stabilizes the RPA-ATR-ATRIP complex at stalled replication forks.

219 inding protein that stabilizes telomeres and stalled replication forks.

220 nt nucleolytic degradation of nascent DNA at stalled replication forks.

221 NA helicase RECQ1, which promotes restart of stalled replication forks.

222 is implicated in the resection of HU-induced stalled replication forks.

223 t, almost nothing is known about the fate of stalled replication intermediates in mitochondria.

224 plication through telomeres via its roles at stalled replication tracts.

225 pre-RC proteins in cycling cells, triggering stalled replication, DNA damage, and death.

226 icase, whose primary role is to help restart stalled replication, serves as a model for Superfamily I

227 e determine the resolution pathway of lesion-stalled replisomes.

228 ion fidelity during the resolution of lesion-stalled replisomes.

229 Finally, using stalling reporters we show that Plasmodium cells evolved

230 ends based on the assumption of no education stalls, resulting in up to half a child per woman less i

231 ic mark 5hmC in maintaining the integrity of stalled RFs and a potential resistance mechanism to PARP

232 ng 5hmC abundance induced the degradation of stalled RFs in KB2P1.21 and human cancer cells by recrui

233 its product 5hmC, and of APE1 recruitment to stalled RFs promoted resistance to the chemotherapeutic

234 re of Dna2's role in controlling the fate of stalled RFs provides a framework to rationalize the invo

235 G]) and promote dissociation of EF-G from FA-stalled ribosome complexes.

236 ples of conserved uORF nascent peptides that stall ribosomes to regulate gene expression in response

237 d other eubacteria, the tmRNA system rescues stalled ribosomes and adds an ssrA tag or degron to the

238 he mycobacterial HflX dissociates antibiotic-stalled ribosomes and rescues the bound mRNA.

239 uring collisions and that the E-sites of the stalled ribosomes appear to become blocked, which sugges

240 onsequently, the transcripts harboring these stalled ribosomes are selectively cleaved by specific RN

241 s about how multiple pathways that recognize stalled ribosomes coordinate to mount the appropriate re

242 l degradation and could include clearance of stalled ribosomes from mRNA, poising mRNA for degradatio

243 s subsequent transpeptidation in transiently stalled ribosomes may become compromised in the absence

244 Cryo-EM structures of stalled ribosomes provide a structural explanation for t

245 , poising mRNA for degradation and rendering stalled ribosomes recyclable by Pelota/Hbs1/ABCE1.

246 Thus, ANKZF1 liberates peptidyl-tRNAs from stalled ribosomes such that the tRNA is checked in an ob

247 stall as well as how cells use RQC to detect stalled ribosomes, ubiquitylate their tethered nascent c

248 idyl transfer RNA (tRNA), respectively, from stalled ribosomes.

249 o modulate the translation of their mRNAs by stalling ribosomes and through ribosome stalling may als

250 The response to DNA damage-stalled RNA polymerase II (RNAPIIo) involves the assembl

251 GreA is characterised to rescue stalled RNAP complexes due to its antipause activity, bu

252 echanism for TFIIH recruitment to DNA damage-stalled RNAPIIo to initiate repair.

253 SA facilitates the association of UVSSA with stalled RNAPIIo.

254 tic ribosome in vitro We found that ribosome-stalled RNH has an increased unfolding rate compared wit

255 competing theories of typhoid proliferation stalled sanitary reform until the provision of cheap ext

256 force to release a stall induced by the SecM stalling sequence and that readthrough of SecM directly

257 By encoding an intrinsic stall site within the template DNA, our chemical transcr

258 the largest ribosome density at established stalling sites.

259 pends on accessory factors for recovery from stalled states and adaptation to environmental changes.

260 ion rates occurs when ribosome collisions at stalls stimulate abortive termination of the leading rib

261 Infusion of epidermal growth factor enabled stalled striatal astrocytes to resume neurogenesis.

262 These stalled structures recruited the majority of the autopha

263 n TC translation speed and the likelihood of stalled TCs such as Harvey have received significant att

264 replication fork progression and restart of stalled telomere replication forks.

265 imply that most cancers suffer frequent fork stalls that are reduced by the HJ removers EME1 and GEN1

266 DNA lesions stall the replisome and proper resolution of these obstr

267 ning and markers for positive selection, has stalled the adaptation of CRISPR/Cas9-mediated genetic t

268 ucts degenerated, causing cholestasis, which stalled the recruitment of phagocytic macrophages and th

269 osilicates increases the Young's modulus and stalls the degradation rate of the resulting hydrogels.

270 natal mice disrupts this healing process and stalls the regrowth of axons, suggesting that microglia

271 n response to DNA damage or replication fork stalling, the basal activity of Mec1(ATR) is stimulated

272 apidly find specific binding sites, and then stalled to the specific sites to form a stable complex f

273 olymerase, Ctf18-RFC can rapidly signal fork stalling to activate the S phase checkpoint.

274 toxin that enlists highly selective ribosome stalling to recalibrate the transcriptome and remodel th

275 for its phosphodiesterase activity removing stalled topoisomerase 2 from DNA, TDP2 has also been sho

276 P(max) ~ 42 k(B)T/s (or 102 kW/mol), and the stall torque: G(stall) ~ 3 k(B)T/rad (or 0.01 nN.nm/rad)

277 ent recruitment of DNA repair factors to the stalled transcription complex.

278 p helicase, which is an enzyme that disrupts stalled transcription complexes.

279 actions between RNAP and DNA and dissociates stalled transcription elongation complexes.

280 g translation extracts reveal that PF846 can stall translation elongation, arrest termination or even

281 suggest that alkylative stress is likely to stall translation in vivo and necessitates the activatio

282 n quality control (RQC) system that resolves stalled translation events is activated when ribosomes c

283 Stalled translation produces incomplete, ribosome-tether

284 ated quality control (RQC) serves to resolve stalled translation, during which untemplated Ala/Thr re

285 hibit the synthesis of specific proteins, by stalling translation elongation.

286 ation on mitochondrial surface is frequently stalled, triggering RQC and CAT-tailing-like C-terminal

287 Ribosome stalling triggers no-go decay (NGD) and ribosome-associa

288 xpressing mice with the PGR antagonist RU486 stalled tumor growth and decreased the expression of cel

289 ight into common principles causing ribosome stalling under physiological conditions.

290 whereby LRRK2-mediated Rab10 phosphorylation stalls vesicle fast recycling to promote PI3K-Akt immuno

291 e collisions that occur during translational stalling, which can alter frameshifting in both the stal

292 light the influence of drug-induced ribosome stalling, which causes bias at translation start sites.

293 Notably, the maturing particles did not stall while waiting for the platform domain to mature an

294 NA and cope with replication fork blocks and stalling, while simultaneously promoting sister chromati

295 th purified yeast components and designed to stall with eIF5B and a nonhydrolyzable GTP analog.

296 translation, particularly when ribosomes are stalled with elongation inhibitors prior to puromycin tr

297 a similar set of agents that cause ribosome stalling, with maximal activation of Hel2 observed at a

298 In the absence of Neurog2, neurogenesis stalls, with a significant reduction in early-born BrdU(

299 d via mutations in the TM, but TM adaptation stalled within about 300 generations.

300 ident cells within the wound bed to overcome stalled wound healing.