ライフサイエンスコーパス: staphylococcal enterotoxin B

1 and structure to the bacterial superantigen staphylococcal enterotoxin B.

2 vivo and in vitro following stimulation with staphylococcal enterotoxin B.

3 n of peripheral blood mononuclear cells with staphylococcal enterotoxin B.

4 nonimmune rabbits or rabbits immunized with staphylococcal enterotoxin B.

5 was reduced by anti-class II MHC Abs and by staphylococcal enterotoxin B.

6 syngeneic T cell-proliferative responses to staphylococcal enterotoxin B.

7 mphocytes in IFN-gamma-/- mice injected with staphylococcal enterotoxin B.

8 h a pool of 300 peptides from TB (MTB300) or staphylococcal enterotoxin B.

9 induced by the atopic dermatitis-associated staphylococcal enterotoxin B.

10 cells of mice immunized with a superantigen, staphylococcal enterotoxin B.

11 lood mononuclear cells (PBMCs) stimulated by staphylococcal enterotoxin B.

12 ules (MTs) is described for the detection of staphylococcal enterotoxin B.

13 positive blastospores or Pep(263) but not by staphylococcal enterotoxin B.

14 hen egg lysozyme, cholera toxin, ricin, and staphylococcal enterotoxin B.

15 s, the loading of an I-A(b)-binding peptide, staphylococcal enterotoxin B 121-136, onto T2-I-A(b) cel

16 In this report, we show that exposure to staphylococcal enterotoxin B, a bacterial superantigen,

17 iber-optic biosensor has been used to detect staphylococcal enterotoxin B, a causative agent of food

18 This phenotype was reproduced with staphylococcal enterotoxin B, a heterologous SAg that al

19 pe mice were injected intraperitoneally with staphylococcal enterotoxin B, a pyrogenic superantigen,

20 s, which is a known motif for recognition of staphylococcal enterotoxin B, a superantigen associated

21 of an additional T cell-activating stimulus, staphylococcal enterotoxin B, Abs to CTLA-4 and PD-1 rev

22 ein and the T-cell receptor and can redirect staphylococcal enterotoxin B-activated T cells to kill i

23 In this study, we show that staphylococcal enterotoxin B activates a Galphaq and PLC

24 Animals treated with lipopolysaccharide or Staphylococcal enterotoxin B alone became tolerant and d

25 were treated daily with saline, 50 microg/kg Staphylococcal enterotoxin B alone, 1000 microg/kg lipop

26 n of naive CD4(+) T lymphocytes with soluble staphylococcal enterotoxin B and anti-CD28.

27 ive response of CD3epsilon.PRS(M) T cells to staphylococcal enterotoxin B and anti-CD3 Ab was normal.

28 e was mecA, Panton-Valentine leukocidin, and staphylococcal enterotoxin B and C negative, toxic shock

29 alysis (BIAcore) revealed that scFvs against staphylococcal enterotoxin B and cholera toxin B subunit

30 c-field-driven assay for fluorescein-labeled staphylococcal enterotoxin B and cholera toxin B was dev

31 in the vaccine, as assessed by responses to staphylococcal enterotoxin B and cytomegalovirus antigen

32 respond poorly to the bacterial superantigen staphylococcal enterotoxin B and do not respond to pepti

33 ed with lipid-complexed plasmid DNA encoding staphylococcal enterotoxin B and either GM-CSF or IL-2.

34 bsequently, solutions of fluorescein-labeled staphylococcal enterotoxin B and fluorescein-labeled cho

35 It was determined that neither staphylococcal enterotoxin B and interleukin-2 activatio

36 logous lymphocytes, activated in vitro using staphylococcal enterotoxin B and interleukin-2 and then

37 in model buffer (PBS-BSA) and 0.1 ng/mL for staphylococcal enterotoxin B and LT.

38 mulation by two fundamentally distinct SAgs, staphylococcal enterotoxin B and Mycoplasma arthritidis

39 lized the clinically important superantigens staphylococcal enterotoxin B and TSS toxin-1 with a sing

40 ssays for detection of both a protein toxin (staphylococcal enterotoxin B) and a small molecule (2,4,

41 potential biological warfare agents, ricin, staphylococcal enterotoxin B, and epsilon toxin, in comp

42 of detection for the toxins (cholera toxin, staphylococcal enterotoxin B, and ricin) were 1.6, 0.064

43 was induced in wild-type mice injected with staphylococcal enterotoxin B, and the administration of

44 iomeningitis virus) infection and bacterial (staphylococcal enterotoxin B) antigen immunization.

45 nd TNF-alpha in CD8(+) T cells responding to staphylococcal enterotoxin B appeared to be largely segr

46 hal doses of staphylococcal enterotoxin A or staphylococcal enterotoxin B at 1 day after burn injury

47 de including the organic photodiode detected Staphylococcal enterotoxin B at concentrations as low as

48 Exposure to the superantigen staphylococcal enterotoxin B augments SLP-76 expression

49 s, including the two MRSA isolates, produced staphylococcal enterotoxins B, C, D, and E on overnight

50 cular permeability, and death in response to staphylococcal enterotoxin B challenge compared with wil

51 In response to staphylococcal enterotoxin B challenge, up-regulation of

52 ccessful in the detection of protein toxins (staphylococcal enterotoxin B, cholera toxin).

53 g viral infection primes mice for subsequent staphylococcal enterotoxin B exposure, possibly via a ga

54 -10 (Fo = 0.16% versus 0.007%; p = 0.04) and staphylococcal enterotoxin B (Fo = 0.49% versus 0.26%; p

55 t mice did not show increased sensitivity to staphylococcal enterotoxin B following adenoviral infect

56 crog/kg lipopolysaccharide with 50 microg/kg Staphylococcal enterotoxin B for 10 days.

57 ecific for CMV pp65(495-503) epitope, or for staphylococcal enterotoxin B, for the expression pattern

58 ystemic adenoviral infection on responses to staphylococcal enterotoxin B in a murine model.

59 epatitis induced by administration of LPS or staphylococcal enterotoxin B in the presence of D-galact

60 n this report show that 1) responsiveness to staphylococcal enterotoxin B in V beta6 T cells was tran

61 re gene expression in T cells activated with staphylococcal enterotoxin B in vivo then cultured with

62 Coinjection of D-galactosamine and LPS or staphylococcal enterotoxin B induced a rapid-onset, low-

63 pplications of a house dust mite extract and Staphylococcal enterotoxin B induced eczematous skin les

64 ich is clearly demonstrated by superantigen (staphylococcal enterotoxin B)-induced deletion of Vbeta8

65 in kinase C-theta (PKC-theta), superantigen (staphylococcal enterotoxin B)-induced deletion of Vbeta8

66 etion of thymocytes, bacterial superantigen (staphylococcal enterotoxin B)-induced elimination of per

67 y similar between human AD skin and allergen/staphylococcal enterotoxin B-induced mouse skin lesions,

68 nditions mimicking a robust immune response (staphylococcal enterotoxin B-induced T cell activation).

69 Among 47 CHIV (median age, 1.5 years), staphylococcal enterotoxin B-induced Th1 cytokine+ and a

70 In contrast, staphylococcal enterotoxin B-induced Th17 cells did not

71 Staphylococcal enterotoxin B induces toxic shock and is

72 gly, anergic Vbeta8(+) T cells isolated from staphylococcal enterotoxin B-injected mice did not exhib

73 alone, coadministration of LPS plus IL-12 or staphylococcal enterotoxin B into scid/scid mice 1 day a

74 tive laser-induced fluorescence detection of staphylococcal enterotoxin B is presented.

75 The combination of lipopolysaccharide and Staphylococcal enterotoxin B leads to late liver injury,

76 gnificant cell adhesion or later response to staphylococcal enterotoxin B-MHC complexes only when Ag

77 In the absence of staphylococcal enterotoxin B, only the combination of Ab

78 -2 in CD4(+) cells that were stimulated with staphylococcal enterotoxin B or cytomegalovirus antigen.

79 PBMC were cultured for 7 d with staphylococcal enterotoxin B or IL-7 in the absence or p

80 erferon-gamma, on mitogenic stimulation with staphylococcal enterotoxin B or on antigenic stimulation

81 Naive T cells primed by (staphylococcal enterotoxin B or tumor-associated protein

82 T, mmCT, or dmLT plus a polyclonal stimulus (staphylococcal enterotoxin B) or specific bacterial Ags,

83 mitogen (phytohemagglutinin), superantigen (staphylococcal enterotoxin B), or anti-CD3 antibody were

84 crog/kg lipopolysaccharide with 50 microg/kg Staphylococcal enterotoxin B, or 100 microg/kg lipopolys

85 vo with myelin oligodendrocyte glycoprotein, Staphylococcal enterotoxin B, or in vitro with anti-CD3

86 Choric exposure to staphylococcal enterotoxin B precipitated a lupus-like i

87 , like TSST-1, is peptide dependent, whereas staphylococcal enterotoxin B presentation is peptide ind

88 reactive response with two targets: CD1a and staphylococcal enterotoxin B presented by classical majo

89 strated decreased pulmonary HIV-specific and staphylococcal enterotoxin B-reactive CD4(+) memory resp

90 howed significant variability over time, but staphylococcal enterotoxin B responses remained relative

91 beta-chain junctional regions of a panel of staphylococcal enterotoxin B-responsive V beta6 T hybrid

92 Chronic exposure to staphylococcal enterotoxin B resulted in a multisystem a

93 on-Tg and Fas-Tg mice, challenging mice with staphylococcal enterotoxin B resulted in significantly h

94 ng in vivo stimulation with the superantigen staphylococcal enterotoxin B resulting in increased T ce

95 d in 15 min, and detection of cholera toxin, staphylococcal enterotoxin B, ricin, and Bacillus globig

96 s could be detected in a single 3 x 3 array: Staphylococcal enterotoxin B, ricin, cholera toxin, Baci

97 perantigens staphylococcal enterotoxin A and staphylococcal enterotoxin B (SEB) 7 days later enhanced

98 ta-chain-SEC3 complex, (2) a complex between staphylococcal enterotoxin B (SEB) and an MHC molecule,

99 after exposure to pathogen-derived inducers staphylococcal enterotoxin B (SEB) and lipopolysaccharid

100 Murine lymphocytes responded less well to staphylococcal enterotoxin B (SEB) and SEA, but mouse ce

101 evaluated the local and systemic effects of staphylococcal enterotoxin B (SEB) and streptococcal pyr

102 Detection of staphylococcal enterotoxin B (SEB) as a bacterial toxin

103 Using the well-characterized Staphylococcal enterotoxin B (SEB) as a model system, we

104 ed quantitative detection in various food of staphylococcal enterotoxin B (SEB) as a model up to 6 pg

105 TCR beta chain (mouse V beta8.2) and the SAG staphylococcal enterotoxin B (SEB) at 2.4 A resolution r

106 phytohemagglutinin (PHA) or the superantigen staphylococcal enterotoxin B (SEB) caused a 3- to 6-fold

107 Staphylococcal enterotoxin B (SEB) causes food poisoning

108 BALB/c mice were exposed to staphylococcal enterotoxin B (SEB) either systemically o

109 We observed that staphylococcal enterotoxin B (SEB) enhanced the IL-4 Der

110 assay (RPLA), were selected for detection of staphylococcal enterotoxin B (SEB) from 77 clinical Stap

111 id substitutions at specific residues of the staphylococcal enterotoxin B (SEB) gene cloned from Stap

112 Using anti-staphylococcal enterotoxin B (SEB) IgG as a "gate" and S

113 e method for the detection of a model toxin, staphylococcal enterotoxin B (SEB) in buffer, apple juic

114 Intranasal exposure to staphylococcal enterotoxin B (SEB) in C57BL/6 wild-type

115 s article, we present the x-ray structure of staphylococcal enterotoxin B (SEB) in complex with its r

116 nologies is used to improve the detection of Staphylococcal enterotoxin B (SEB) in food.

117 production as well as toxic shock induced by staphylococcal enterotoxin B (SEB) in HLA class II trans

118 ed the effects of the bacterial superantigen staphylococcal enterotoxin B (SEB) in mice.

119 T cells from wild-type mice were primed with staphylococcal enterotoxin B (SEB) in vitro, which induc

120 We activated Vbeta8(+) T cells with staphylococcal enterotoxin B (SEB) in vivo and monitored

121 In normal mice, injection of 1-100 microg of staphylococcal enterotoxin B (SEB) induced clonal elimin

122 consequences of Mycobacterium bovis BCG and staphylococcal enterotoxin B (SEB) inoculation in vivo i

123 The bacterial superantigen staphylococcal enterotoxin B (SEB) interacts with T cell

124 Staphylococcal enterotoxin B (SEB) is a bacterial supera

125 Staphylococcal enterotoxin B (SEB) is a bacterial supera

126 Staphylococcal enterotoxin B (SEB) is a potent superanti

127 Staphylococcal enterotoxin B (SEB) is a potent toxin tha

128 Staphylococcal enterotoxin B (SEB) is a superantigen kno

129 Staphylococcal enterotoxin B (SEB) is a superantigen tha

130 Staphylococcal enterotoxin B (SEB) is a superantigen tha

131 T-cell stimulating activity of Staphylococcal enterotoxin B (SEB) is an important facto

132 re to the Staphylococcus aureus superantigen staphylococcal enterotoxin B (SEB) may occur accidentall

133 we measured the binding of a set of SEC3 and staphylococcal enterotoxin B (SEB) mutants to soluble re

134 d the utility of two recombinantly expressed Staphylococcal Enterotoxin B (SEB) mutants, a single poi

135 Various in vitro effects of staphylococcal enterotoxin B (SEB) on human peripheral b

136 with purified T cells and the superantigens staphylococcal enterotoxin B (SEB) or toxic shock syndro

137 lpha), while stimulation of these cells with staphylococcal enterotoxin B (SEB) or toxic shock syndro

138 l clone HA-1.70 with either the superantigen staphylococcal enterotoxin B (SEB) or with a specific an

139 Systemic exposure to staphylococcal enterotoxin B (SEB) rapidly and selective

140 Stimulation of T-cells with staphylococcal enterotoxin B (SEB) significantly elevate

141 The superantigen staphylococcal enterotoxin B (SEB) simultaneously binds

142 oduced interferon (IFN) gamma in response to staphylococcal enterotoxin B (SEB) stimulation in 382 he

143 When mice were injected with staphylococcal enterotoxin B (SEB) superantigen and H57-

144 A macaque model was employed to explore staphylococcal enterotoxin B (SEB) superantigen-driven T

145 fall into two groups: superantigens such as staphylococcal enterotoxin B (SEB) that contain a single

146 de inhibits the binding of the super-antigen staphylococcal enterotoxin B (SEB) to IAk.

147 m. immunization of rabbits with formalinized staphylococcal enterotoxin B (SEB) toxoid in saline elic

148 esent a new homogeneous detection method for staphylococcal enterotoxin B (SEB) utilizing core-shell-

149 ection system for immunological detection of staphylococcal enterotoxin B (SEB) was designed, fabrica

150 A candidate vaccine against staphylococcal enterotoxin B (SEB) was developed using a

151 A rapid and sensitive detection of staphylococcal enterotoxin B (SEB) was developed using a

152 ine production to an exogenous superantigen, staphylococcal enterotoxin B (SEB) was diminished in HLA

153 lasmon resonance (SPR) detection signal from staphylococcal enterotoxin B (SEB) was dramatically incr

154 or Bacillus globigii, MS2 bacteriophage, and staphylococcal enterotoxin B (SEB) were 10(5) cfu/mL, 10

155 Staphylococcal enterotoxin B (SEB), a potential biologic

156 develop an antibody (Ab) therapeutic against staphylococcal enterotoxin B (SEB), a potential incapaci

157 Staphylococcal enterotoxin B (SEB), a primary cause of f

158 Staphylococcal enterotoxin B (SEB), a shock-inducing exo

159 Bacterial superantigens, such as staphylococcal enterotoxin B (SEB), can trigger acute pa

160 er with superantigen-producing S. aureus, or staphylococcal enterotoxin B (SEB), caused a heightened

161 Superantigens, such as staphylococcal enterotoxin B (SEB), elicit a strong prol

162 t physiologically relevant concentrations of staphylococcal enterotoxin B (SEB), F1 antigen from Yers

163 ss spectrometry to identify a protein toxin, staphylococcal enterotoxin B (SEB), in a model food matr

164 Staphylococcal superantigens, including staphylococcal enterotoxin B (SEB), promote vigorous T c

165 e TCR Vbeta domain fail to respond the bSAGs staphylococcal enterotoxin B (SEB), SEC1, SEC2, and SEC3

166 Clostridium perfringens epsilon toxin (ETX), staphylococcal enterotoxin B (SEB), shiga toxin (STX), a

167 the potential role played by superantigens, staphylococcal enterotoxin B (SEB), staphylococcal enter

168 rvival after challenge with the superantigen staphylococcal enterotoxin B (SEB), using lipopolysaccha

169 the ability of two overlapping fragments of staphylococcal enterotoxin B (SEB), which encompass the

170 esicular stomatitis virus (VSV) can redirect staphylococcal enterotoxin B (SEB)-activated T cells to

171 ded in the analysis, out of which 25.3% were staphylococcal enterotoxin B (SEB)-IgE positive.

172 5) and Fas ligand (FasL) play major roles in staphylococcal enterotoxin B (SEB)-induced peripheral de

173 ufficient counterparts for responsiveness to staphylococcal enterotoxin B (SEB).

174 cycle upon stimulation with the superantigen staphylococcal enterotoxin B (SEB).

175 ntiation of T cells following treatment with staphylococcal enterotoxin B (SEB).

176 ultures were stimulated with graded doses of staphylococcal enterotoxin B (SEB).

177 intracutaneous injection of small amounts of staphylococcal enterotoxin B (SEB).

178 d immunoassays of a common food-borne toxin, Staphylococcal enterotoxin B (SEB).

179 isms with particular emphasis on the role of staphylococcal enterotoxin B (SEB).

180 xemplified by ricin, cholera toxin (CT), and staphylococcal enterotoxin B (SEB).

181 finity agents to neutralize the potent toxin staphylococcal enterotoxin B (SEB).

182 lls are hyperresponsive to SAgs, typified by staphylococcal enterotoxin B (SEB); ii) the human MAIT c

183 or saline control (n = 30) for 60 hrs after staphylococcal enterotoxin B (SEB; 10 microg iv) and a s

184 administration by a single i.p. injection of staphylococcal enterotoxin B (SEB; 10 micrograms/mouse)

185 cell transfer with the bacterial enterotoxin staphylococcal enterotoxin-B (SEB), which naturally link

186 ts in the activation of human T cells by the staphylococcal enterotoxins B (SEB), C1 (SEC1), and D (S

187 ermore, syndecan-1-null mice challenged with staphylococcal enterotoxin B showed enhanced T cell accu

188 e with TCR transgenic mice or treatment with staphylococcal enterotoxin B showed that the defect was

189 Prior host exposure to staphylococcal enterotoxin B significantly enhanced fibr

190 versus unoriented constructs in an assay for staphylococcal enterotoxin B spiked into buffer showed t

191 Two days after exposure to the superantigen staphylococcal enterotoxin B, splenocytes cultured with

192 Staphylococcal enterotoxin B stimulated similar cytokine

193 ent of loss of memory CD4+ T lymphocytes and staphylococcal enterotoxin B-stimulated cytokine product

194 Staphylococcal enterotoxin B-stimulated IL-2-producing c

195 gp modulation, P-gp activity was measured in staphylococcal enterotoxin B-stimulated peripheral blood

196 uantified in either anti-CD3/28 antibody- or staphylococcal enterotoxin B-stimulated single-positive

197 hanced activation-induced proliferation (via staphylococcal enterotoxin B stimulation) but inhibited

198 In response to staphylococcal enterotoxin B stimulation, beta-cat(Tg) m

199 cytokine production by cells in response to staphylococcal enterotoxin B stimulation.

200 n of T cells in responses to anti-CD3 mAb or staphylococcal enterotoxin B stimulation.

201 vide or divided only once in the presence of staphylococcal enterotoxin B, suggesting that virus prod

202 deletion of CD4+/CD8+ thymocytes induced by staphylococcal enterotoxin B superantigen and specific p

203 Finally, the inoculation of staphylococcal enterotoxin B superantigen into SIV-infec

204 vels of this cytokine after stimulation with staphylococcal enterotoxin B superantigen.

205 with CpG and stimulation of the TCR with the staphylococcal enterotoxin B superantigen.

206 n the in vitro response to the superantigen, staphylococcal enterotoxin B, the usually observed parti

207 to TSS induced by an unrelated superantigen (staphylococcal enterotoxin B), they were completely resi

208 capable of continuously delivering the SAg, staphylococcal enterotoxin B (total of 10 mug/mouse), or

209 hat the PLCbeta inhibitor U-73122 sensitizes staphylococcal enterotoxin B-treated mice to dexamethaso

210 ty and percentage of IL-15-positive cells in Staphylococcal enterotoxin B-treated monocytes of AD pat

211 IL-15 secretion by Staphylococcal enterotoxin B-treated PBMC of AD patients

212 In adenovirus-infected mice, staphylococcal enterotoxin B triggered a more profound h

213 ative response of Vbeta8(+)CD4(+) T cells to staphylococcal enterotoxin B was comparable in LIGHT(-/-

214 +)CD8(+) T cell proliferation in response to staphylococcal enterotoxin B was significantly lower in

215 T cells stimulated with anti-CD3 antibody or staphylococcal enterotoxin B, we found that chlorampheni

216 holera toxin, ricin, shiga-like toxin 1, and staphylococcal enterotoxin B were performed simultaneous

217 ytes, and leukocytes stimulated ex vivo with Staphylococcal enterotoxin B, which mimics some of the c

218 verity of liver injury following exposure to staphylococcal enterotoxin B without d-galactosamine sen