ライフサイエンスコーパス: staple

1 n contamination, and where corn is a dietary staple.

2 cting residues with a constraining, olefinic staple.

3 people who rely on sorghum as their dietary staple.

4 and arsenic impacted regions where rice is a staple.

5 (10) S(10) P(10) Cl(5) rings and five S-Ag-S staples.

6 ric [-S-Au-S-] and 6 dimeric [-S-Au-S-Au-S-] staples.

7 conformation is present upon removing eight staples.

8 of peptides and for the synthesis of peptide staples.

9 brane complexes through hydrocarbon-mediated stapling.

10 sis of a bis-oxaziridine reagent for peptide stapling.

11 fective cellular activity is achieved by the stapled 1:1 alpha/Sulfono-gamma-AA peptides, evidenced b

12 rved with circular stapling (17%) and linear stapling (15%).

13 hile lower rates were observed with circular stapling (17%) and linear stapling (15%).

14 r stapled (52%), hand-sewn (30%), and linear stapled (18%) anastomotic techniques were used.

15 ghest leakage rate (26%), followed by linear stapling (18%) and circular stapling (6%).

16 rates after intrathoracic end-to-side double-stapling (23.3%) and cervical end-to-side hand-sewn (25.

17 s have potential advantages over suturing or stapling(5,6), existing liquid or hydrogel tissue adhesi

18 Circular stapled (52%), hand-sewn (30%), and linear stapled (18%)

19 , 99.9% of all women had consumed cereal and staples, 57.9% meats, 4.7% eggs, and 0.5% nuts and seeds

20 llowed by linear stapling (18%) and circular stapling (6%).

21 the wound are brought together with sutures, staples, adhesive glue or clips.

22 rcement of fissure openings as compared with stapling alone, with or without tissue sealant or glue,

23 eable, hydrocarbon-stapled synthetic peptide stapled alpha-helical peptide derived from mastermind-li

24 inity differences of a set of perfluoroarene stapled alpha-helical peptides of the BIM BH3 peptide to

25 ructurally and functionally mimic the parent stapled alpha-peptide in its ability to enter certain ty

26 We show that a stapled alpha/beta-peptide can structurally and function

27 places isoleucine 689 with an S-gamma-methyl stapled amino acid, and has significantly higher affinit

28 a methyl group in the gamma-position of the stapling amino acid S5.

29 Here, we analyzed a 58-member library of stapled AMPs (StAMPs) based on magainin II and applied t

30 ess frequently in the patients who underwent stapled anastomosis (P = 0.004).

31 being significantly higher than that in the stapled anastomosis group (8 cases or 5.33%; P = 0.002).

32 carried out in 271 (62.5%) patients, whereas stapled anastomosis was performed in 162 (37.4%) patient

33 ein binding motif onto a covalent side-chain staple and applied to the peptide to enhance its helicit

34 Wheat has become the world's major staple and its consumption correlates with prevalence of

35 The sham diet restricted a similar number of staple and non-staple foods as the low FODMAP diet; the

36 - 84.33 min and 250.55 +/- 43.31 min for the stapled and hand-sewn anastomosis groups, respectively (

37 Here, combined peptide stapling and PEG-fatty acid conjugation affords potent P

38 9) or cervical (n = 255) side-to-side linear-stapled, and cervical end-to-side hand-sewn (n = 175).

39 s major organic forms from commonly consumed staples, and the effect of heat processing on the same.

40 the respective roles of the kernel, surface staples, and the type of ligands on catalysis.

41 ture of an HIV-1 entry inhibitor peptide two stapled- and a retro-enantio peptides have been designed

42 Radiation therapy is a staple approach for cancer treatment, whereas radioresis

43 Examples of the novel multicomponent peptide stapling approach and heterocycle ring-forming macrocycl

44 e, we report the use of a diversity-oriented stapling approach to produce autophagy-inducing peptides

45 d that a macrocyclic peptide formed by ReACT stapling at methionine exhibited improved uptake into li

46 15), whereas Au(22)Cd(1)(SAdm)(16) lacks one staple Au atom compared to Au(24)(SAdm)(16) and thus the

47 We measured FA and folate content in dietary staples (bakery bread and tortillas) using microbial ass

48 ssemblies are held together by 120 S-Au(i)-S staples between the protein oligomers, and exist in two

49 Here we report the crystal structure of a stapled bicyclic peptide inhibitor G7-B1 in complex with

50 since the origins of the discipline and is a staple bioanalytical method for efforts ranging from res

51 Double-click stapling can enhance the binding affinity, proteolytic s

52 r basis of zinc (Zn) uptake and transport in staple cereal crops is critical for improving both Zn co

53 o-side esophago-gastrostomy and side-to-side stapled cervical esophagogastric anastomosis after esoph

54 Side-to-side stapled cervical esophagogastric anastomosis may reduce

55 d-sewn esophago-gastrostomy and side-to-side stapled cervical esophagogastric anastomosis.

56 olated from 123 "donuts" of patients where a stapled colorectal anastomosis was made and was analyzed

57 Rice is a major staple crop and immensely affected by soil salinity.

58 Staple crop biofortification through gene stacking, usin

59 vided by consumption of storage roots of the staple crop cassava (Manihot esculenta Crantz) in West A

60 lives in countries sourcing nearly all their staple crop imports from partners who deplete groundwate

61 Cassava is an important staple crop in sub-Saharan Africa, due to its high produ

62 cereals, rice is the second most cultivated staple crop in the world.

63 Cassava is an important staple crop in tropical and sub-tropical areas.

64 sis of proposed hyperosmolality sensing in a staple crop plant, extend our knowledge of the anoctamin

65 Here, we study genome-wide variation in the staple crop Sorghum bicolor (L.) Moench and its associat

66 by poor bioactivity in wheat, a widely grown staple crop, and in tomato.

67 chers and breeders to improve this important staple crop.

68 wth measurements to map QTL in rice, a major staple crop.

69 ome-enabled breeding efforts to improve this staple crop.

70 nd children in the development of maize as a staple crop.

71 Fs averaged 11.13%-13.95% for the three main staple crops (i.e., maize, wheat, and rice), together ac

72 h, as the major nutritional component of our staple crops and a feedstock for industry, is a vital pl

73 ncreasing the selenium (Se) concentration of staple crops by fertilization is a valuable pathway to i

74 ugarcane, jatropha, and eucalyptus, and that staple crops have lower water requirements (<7,000 m(3)h

75 The rate of annual yield increases for major staple crops must more than double relative to current l

76 re these data with two baseline scenarios of staple crops representing previous water demand.

77 thogens, causing significant yield losses on staple crops such as rice and wheat.

78 global health issue, but the iron content of staple crops such as wheat (Triticum aestivum) is diffic

79 Understanding extreme weather impacts on staple crops such as wheat is vital for creating adaptat

80 cy in a wide variety of cereal species - the staple crops that feed the world.

81 w improved strategies for the engineering of staple crops to accumulate additional bioavailable iron

82 Improving productivity of the staple crops wheat and rice is essential to feed the gro

83 Understanding the function of genes within staple crops will accelerate crop improvement by allowin

84 Potato, one of the most important staple crops, originates from the highlands of the equat

85 es the indium uptake and accumulation by two staple crops, rice (Oryza sativa L.) and wheat (Triticum

86 tant viral disease affecting one of Africa's staple crops.

87 at annually destroys millions of hectares of staple crops.

88 isen, standing in stark contrast to other US staple crops.

89 eaves and edible parts of three East African staple crops: Zea mays, Manihot esculenta, and Musa acum

90 s lowered upon omission of four specific DNA staples (defect).

91 ation of a set of alpha-helical peptides and stapled derivatives that specifically targeted the LDH t

92 where people must rely upon sorghum as their staple diet.

93 At high doses, staple dissociation increases which causes structural di

94 d tether-nucleic acid strands and additional staple elements with long nucleic acid chains, acting as

95 In one case (MAP-1) where stapling enhanced alpha-helicity in aqueous and lipid en

96 ficacy and postoperative advantages surround stapled esophagogastric anastomosis compared with the ha

97 ng (13.9%), and cervical side-to-side linear-stapled esophagogastrostomies (11.8%) (P < 0.001).

98 Accounting for dietary staples' FA fortification increased population estimates

99 hose with a looser structure (knitted, short staple fibers, lower twist).

100 Khambir is a leavened staple food among the native highlanders of Western Hima

101 s human population is dependent on rice as a staple food and chemical pesticides to control pests is

102 DOCK8-deficient patients is directed against staple food antigens but not house dust mites.

103 a (Manihot esculenta Crantz) is an important staple food crop in Africa and South America; however, u

104 Wheat (Triticum aestivum) is a major staple food crop worldwide.

105 e genome-wide association mapping in rice, a staple food crop.

106 Despite these attributes as staple food crops and sources of high-value chemicals, D

107 y significantly to meeting future demand for staple food crops given that an 8% yield increase across

108 uently, the demand for climate resilience of staple food crops such as wheat must be better articulat

109 ation processes of maize and rice, two major staple food crops that feed the world.

110 Improving essential nutrient content in staple food crops through biofortification breeding can

111 Food security relies on the resilience of staple food crops to climatic variability and extremes,

112 Staple food crops, including cowpea (Vigna unguiculata)

113 Cassava is a major staple food for about 800 million people in the tropics

114 potatoes (Solanum tuberosum andigenum) are a staple food for Andean population; there is great biodiv

115 Rice is the staple food for more than 50% of the world's population(

116 llet [Cenchrus americanus (L.) Morrone] is a staple food for more than 90 million farmers in arid and

117 Rice is a staple food for nearly half of the world's population, b

118 Rice is a staple food for over half of the world's population, but

119 Rice is a staple food in many countries around the world and it is

120 fruit in the world market and is consumed as staple food in many countries.

121 he production of sweetpotatoes, an important staple food in Sub-Saharan Africa.

122 Eggs are staple food in the human diet and are consumed globally.

123 to 6,000 cal B.P. and its earliest use as a staple food in this area of the Andes between 5,000 and

124 Rice is staple food of nearly half the world's population.

125 Quercus acorns have been used as a staple food since archeological times; currently, there

126 Rice (Oryza sativa) provides a staple food source for more than 50% of the world's popu

127 Rice (Oryza sativa L.) is the primary staple food source for more than half of the world's pop

128 Apios (Apios americana Medik.), once a staple food source of Native American Indians, produces

129 Bread is a staple food that is traditionally made from wheat flour.

130 Rice is grown as a staple food, and the bran is used as animal feed or wast

131 t is one of the world's most widely consumed staple food.

132 reasing interest worldwide as an alternative staple food.

133 countries where people eat mostly rice as a staple food.

134 people who depend primarily on rice as their staple food.

135 regions where thiamine-poor white rice is a staple food.

136 poor Africans that depend upon plantain as a staple food.

137 onutrient intakein countries where rice is a staple food.

138 we determined the levels of IgE specific for staple foods and house dust mite allergens in DOCK8-defi

139 estricted a similar number of staple and non-staple foods as the low FODMAP diet; the diets had simil

140 nihot esculenta) is among the most important staple foods in the world, sustaining hundreds of millio

141 Legumes represent staple foods rich in phenolic compounds, which are often

142 of large-scale food fortification (LSFF) of staple foods to prevent micronutrient deficiencies in hi

143 Iron (Fe) is an important mineral element in staple foods which is required in sufficient bioaccessib

144 The biofortification of staple foods with carotenoids provides an efficient deli

145 0 countries to establish programs to fortify staple foods with folic acid to prevent neural tube birt

146 Despite accounting for FA-fortified staple foods, 9-33% of women of childbearing age still h

147 ear evidence for the consumption of expected staple foods, such as cereals (Triticeae), sesame (Sesam

148 may consume smaller quantities of fortified staple foods.

149 the iron and zinc availabilities in African staple foods.

150 Roots, tubers, and bananas (RTB) are vital staples for food security in the world's poorest nations

151 s have potential advantages over sutures and staples for wound closure, hemostasis, and integration o

152 ed binding mode of the peptide, in which the staple forms an alternative contact with the surface of

153 An array of 6 linear Ag(2) staples further surround this Ag(60) shell.

154 landraces of maize productive enough to be a staple grain existed in Central America by 4,300 cal B.P

155 of genetic diversity as maize was becoming a staple grain in Central and Mesoamerica.

156 ear when maize was productive enough to be a staple grain in the Americas.

157 ositions should be avoided when applying the stapling groups.

158 Modern gluten-containing staples had levels of TLR4-activating ATIs that were as

159 24 (7%) of 338 participants who received stapled haemorrhoidopexy and 33 (9%) of 352 participants

160 777 patients were randomised (389 to receive stapled haemorrhoidopexy and 388 to receive traditional

161 excisional surgery should be considered over stapled haemorrhoidopexy as the surgical treatment of ch

162 ical effectiveness and cost-effectiveness of stapled haemorrhoidopexy compared with traditional excis

163 raditional excisional surgery group than the stapled haemorrhoidopexy group over 24 months; mean diff

164 antly better quality of life scores than the stapled haemorrhoidopexy group.

165 EQ-5D-3L was higher for stapled haemorrhoidopexy in the first 6 weeks after surg

166 sex, and centre with an automated system to stapled haemorrhoidopexy or traditional excisional surge

167 Stapled haemorrhoidopexy was less painful than tradition

168 ive either traditional excisional surgery or stapled haemorrhoidopexy.

169 orrhoids; traditional excisional surgery and stapled haemorrhoidopexy.

170 Peptide stapling has benefited from the development of several c

171 rolled data comparing Kono-S anastomosis and stapled ileocolic side-to-side anastomosis.

172 gh-resolution, multiplexed experiments are a staple in cellular imaging.

173 reagents in oxidative processes has become a staple in modern organic synthesis.

174 iginating from South America that is a major staple in the tropics, including in marginal environment

175 Radiation is a staple in therapeutic regimens, although cells surviving

176 f genetically encoded, nonreducible covalent staples in a target protein scaffold using computational

177 and corn masa-based foods, which are dietary staples in Mexico.

178 ons of the molecular composition of key food staples incorporated into contemporary diets and how the

179 ect local reactivity: the removal of the DNA staples increased the computed accessibility to a restri

180 g closing metathesis to show that the closed staple is essential to the target interaction.

181 Unregulated FA fortification of dietary staples leads to unpredictable total folate intake witho

182 This indicates that the fiber staple length and/or debris encapsulated inside the fabr

183 r core geometric stability and the optimally stapled ligand-capping anchor and secure the stability o

184 rminal hydroxyls on (100) surface, forming a staple-like local structure with each Ag atom bonded wit

185 Staple line disruption may still lead to sepsis, multior

186 and distance from the pylorus (DP) where the staple line is initiated.

187 Staple line leak rate decreased from 6.5% to 1.4%.

188 f procedure only had a significant impact on staple line leakage rate.

189 Staple line leakage, as the most frequent and most feare

190 for patients who experienced anastomotic or staple line leaks after bariatric surgery, and then eval

191 tents can successfully treat anastomotic and staple line leaks after bariatric surgery.

192 1%), esophago-enteric leak from anastomosis, staple line or localized conduit necrosis (19%), and atr

193 2%), esophago-enteric leak from anastomosis, staple line or localized conduit necrosis (9%), and acut

194 leeve gastrectomy (LSG) including the use of staple line reinforcement (SLR), bougie size (BS), and d

195 the pancreatic duct, staple size, the use of staple line reinforcement, tissue patches, biologic seal

196 bagging specimen, and 7) final inspection of staple line.

197 The Staple-line Reinforcement for Prevention of Pulmonary Ai

198 ATA: No randomized trial evaluating alginate staple-line reinforcement has been performed to date.

199 No randomized trial evaluating alginate staple-line reinforcement has been performed to date.

200 dy was to determine the efficacy of alginate staple-line reinforcement of fissure openings as compare

201 More broadly, diversity-oriented stapling may provide a promising alternative to polycati

202 The staple moieties introduce local conformational changes n

203 Compared to the discrete staple motifs in gold:thiolate nanoparticles, the Cu-thi

204 Despite the presence of such diverse staple motifs, Au279S84 structure has a chiral pseudo-D3

205 Au249 core is protected by three types of staple motifs, namely: 30 bridging, 18 monomeric, and 6

206 ly: 30 bridging, 18 monomeric, and 6 dimeric staple motifs.

207 18 kernel protected by six dimeric Au2 (SR)3 staple motifs.

208 ar-stapled technique in 427 patients (double-stapling n = 90, purse-string n = 337), intrathoracic (n

209 turn the computation of lower bounds into a staple of eigenvalue and spectral problems in physics an

210 n profiling of mammalian cells is becoming a staple of many published biomedical and biological resea

211 Human tissue culture cells have long been a staple of molecular and cell biology research.

212 seases and traits and should be considered a staple of network-based gene classification workflows.

213 Although C-C bond formation has been a staple of organic synthesis, the direct transfer of prim

214 Despite being a staple of our science, the process of pre-publication pe

215 It is a staple of quantum chemistry and physics computations.

216 ular, while X-ray crystallography has been a staple of structural biology for more than half a centur

217 Poly(p-phenylenevinylene)s (PPVs), a staple of the conductive polymer family, consist of alte

218 an analysis of a complete supply chain for a staple of the global diet, a loaf of bread.

219 dable sequencing of pathogen genomes - now a staple of the public health microbiology laboratory in w

220 graecum) is an annual herbaceous plant and a staple of traditional health remedies for metabolic cond

221 Stapling of side chains to stabilize an alpha-helical st

222 opsy, 4) gastrocolic ligament dissection, 5) stapling of the stomach, 6) bagging specimen, and 7) fin

223 ne the impact of FA fortification of dietary staples on the proportion of the population consuming be

224 ides containing two cysteine residues can be stapled or cyclized using homobifunctional allylic carbo

225 Our most potent stapled peptide binds to RAP1 protein with a Ki value of

226 s reactions, and a strained 14-membered ring stapled peptide by means of macrocyclic ring-closing met

227 Surprisingly, Bclw or a stapled peptide corresponding to the Bclw BH4 domain int

228 resulting in the synthesis of a cell-active stapled peptide for further development in manipulating

229 partner can assist in the rational design of stapled peptide inhibitors targeting a protein-protein i

230 F4E binding, warranting the investigation of stapled peptide mimics for manipulating eIF4E PPIs.

231 Sld5 CIP, we identified an unorthodox i,i+6 stapled peptide with improved, submicromolar binding to

232 y, the solution structure of the most potent stapled peptide, DD5-o, revealed an alpha-helical confor

233 ich RAB25 is pro-oncogenic with an optimized stapled peptide, RFP14, inhibits migration, and prolifer

234 lize its oncogenic activity using a covalent stapled-peptide inhibitor.

235 efficiencies that rival those of hydrocarbon-stapled peptides active in animals and man.

236 Hydrocarbon-stapled peptides are a class of bioactive alpha-helical

237 Stapled peptides are short peptides that are locked into

238 estioned the mechanistic specificity of such stapled peptides based on interrogating their capacity t

239 ration were used to design second-generation stapled peptides based on RLIP76 that exhibited vastly i

240 We show herein that stapled peptides can be rendered highly cell-permeable b

241 Nearly all stapled peptides caused less membrane perturbation (vesi

242 optimization, and validation of double-click stapled peptides encoding the Ctf4-interacting peptide (

243 Relative to unmodified peptides, optimized stapled peptides exhibit increased structural stability,

244 ar distribution, in evaluating and advancing stapled peptides for clinical translation.

245 However, most of the stapled peptides have limited cell permeability or are i

246 Stapled peptides recapitulate the binding affinity and s

247 Stapled peptides successfully competed with multiple Ral

248 Here, we show that stapled peptides targeting the interface between NCKAP1

249 design and characterization of alpha-helical-stapled peptides that bind selectively to active, GTP-bo

250 x, we have developed first-in-class triazole-stapled peptides that block the protein-protein interact

251 Hydrocarbon-stapled peptides that display key residues of the p53 tr

252 in the trafficking of CPMPs and hydrocarbon-stapled peptides to the cytosol.

253 ank-ordering the binding affinities of these stapled peptides with respect to the BIM BH3 peptide.

254 Here, we compare four amphiphilic stapled peptides with their linear counterparts in terms

255 We have previously reported stapled peptides, based on the Ral effector RLIP76, that

256 existing crystallographic data, we developed stapled peptides, referred to as WASF Helix Mimics (WAHM

257 rational inhibitor design through the use of stapled peptides.

258 We found that these stapling peptides have increased alpha-helicity and impr

259 most recent decades, hydrocarbon bridges to "staple" peptides across side chains or hydrogen bond sur

260 "Stapled" peptides are typically designed to replace two

261 780,000 y old, reflects a varied plant diet, staple plant foods, environmental knowledge, seasonality

262 ahedron shell, rather than at the central or staple position, as often reported.

263 ere, we develop a protocol to obtain optimal stapling positions computationally.

264 By screening stapling positions in the Sld5 CIP, we identified an uno

265 in most current programs, choosing the best stapling positions is usually a trial-and-error process.

266 ves may follow the winter migration of their staple prey, moose (Alces alces), to lower altitudes.

267 ds prepared from cereal grains are a dietary staple, providing a significant proportion of daily ener

268 As major food staple, rice (Oryza sativa L.) is cultivated in irrigate

269 Complex scaffold and staple routing needed to design wireframe DNA origami ob

270 custom template strand by binding individual staple sequences to multiple locations on the template.

271 ion, suture ligation of the pancreatic duct, staple size, the use of staple line reinforcement, tissu

272 was confirmed by a crystal structure of the stapled Sld5 peptide bound to Ctf4.

273 The stapled Sld5 peptide was able to displace the Ctf4 partn

274 The yam products can serve as staple source of energy to consumers.

275 We show that a lead double-stapled StAMP named Mag(i+4)1,15(A9K,B21A,N22K,S23K) can

276 affold strand is assembled with a many short staple strands into parallel arrays of double helices, h

277 introduction of DNA origami, which uses many staple strands to fold one long scaffold strand into a d

278 ndreds of short DNA oligonucleotides, called staple strands, to fold a long single-stranded DNA, whic

279 purification, even in the presence of excess staple strands.

280 stacked 12 DNA quasi-rings interlinked by 30 staple-strands.

281 lex by using the cell-permeable, hydrocarbon-stapled synthetic peptide stapled alpha-helical peptide

282 er ttMIE: intrathoracic end-to-side circular-stapled technique in 427 patients (double-stapling n = 9

283 ight from anal verge was 3.0 +/- 2.0 cm with stapled techniques accounting for 66.0%.

284 Cereal grains are the common food staples that collectively provide over 50% of dietary ca

285 is shaped into desired nanostructure by DNA staples that form Holliday junctions with the template.

286 mpounds, while also enabling proximity-based stapling through a DA dimerization reaction.

287 struments, including UV transilluminators, a staple to any molecular biology laboratory.

288 overed with a C-seal, a bioresorbable sheath stapled to the anastomosis.

289 ut which cultivars of current or future food staples to incorporate into existing and future food sys

290 say to screen a small library of aryl-carbon-stapled transmembrane-mimicking peptides produced by sol

291 HBS stapled Trp peptide exhibited signs of steric hindrance

292 ain largely neglected in comparison to other staple tuber crops of tropical agricultural systems such

293 Furthermore, ssDNA appears to staple two monomers to nucleate decamer assembly.

294 peptide to their N-terminus, C-terminus, or stapling unit.

295 By the functionalization of one group of staple units with programmed tether-nucleic acid strands

296 ets and how the nutrient landscapes of these staples vary as a function of cultivar and food processi

297 FA content in dietary staples was variable, whereas use of FA-fortified flour

298 The impact of lactam stapling was found to vary strongly with regard to the d

299 n methanol, stabilized by an unusual (i,i+3) staple which cross-links two d-amino acids.

300 eratures likely affected the productivity of staple wild cereal resources.