ライフサイエンスコーパス: start site

1 atin state to another at their transcription start site.

2 ,214 nt upstream from the PDE3A1 translation start site.

3 S) 87 kb upstream of the RANKL transcription start site.

4 the NEIL3 PQS located near the transcription start site.

5 located upstream of the major transcription start site.

6 asis of their proximity to the transcription start site.

7 that are more proximal to the transcription start site.

8 paused RNA polymerase II downstream from the start site.

9 yielding a protein with a unique translation start site.

10 tyrosine 88 upstream of the AR transcription start site.

11 h increasing distance from the transcription start site.

12 anscribed regions toward the transcriptional start site.

13 bdominant peak upstream of the transcription start site.

14 II that is preassembled at the transcription start site.

15 n of Pol II release from the transcriptional start site.

16 eosomes phased relative to the transcription start site.

17 ed just upstream of the cxcr4b transcription start site.

18 to a site close to the ANO1 transcriptional start site.

19 window of fixed size at their transcription start sites.

20 e stalling, which causes bias at translation start sites.

21 on is achieved via alternative transcription start sites.

22 omplexes to local and distal transcriptional start sites.

23 ing genic enhancers and active transcription start sites.

24 ks identified in enhancers and transcription start sites.

25 ethyl (H3K4me2) extended farther upstream of start sites.

26 h upstream and downstream of transcriptional start sites.

27 ions and also present multiple transcription start sites.

28 ranscripts displaying intronic transcription start sites.

29 t via a decrease of H3K4me3 at transcription start sites.

30 ol II) occupancy downstream of transcription start sites.

31 ment, especially in the detection of correct start sites.

32 equency and GC enrichment near transcription start sites.

33 are near or far from annotated transcription start sites.

34 they are located within active transcription start sites.

35 ncreased accumulation around transcriptional start sites.

36 rease of the H3K4me3 mark at transcriptional start sites.

37 osomes at the early and late transcriptional start sites.

38 We identified 248 transcriptional start sites, 116 transcriptional termination sites and 8

39 ions, 231 exon extensions, 192 novel protein start sites, 19 novel translational frames, 28 events of

40 (kb) downstream of the Irf8 transcriptional start site (+32-kb Irf8) that was active in mature cDC1s

41 splicing event identified was an alternative start site (39%), MBD-seq genome-wide CpG methylation da

42 n within 500 base pairs of the transcription start site and akin to its bacterial homologue NusG.

43 ichment and depletion near the transcription start site and identify triplets that have the strongest

44 ing the DNA strands around the transcription start site and phosphorylating the C-terminal domain for

45 ibed genes with preference for transcription start site and promoter regions and a large number of ac

46 leasing paused RNAPII near the transcription start site and promoting transcription elongation.

47 ications around the Cga gene transcriptional start site and that JNK inhibition dramatically reduces

48 -loops are bounded between the transcription start site and the first exon-intron junction.

49 ny kilobases downstream of the transcription start site and to produce invariably tight repression of

50 loops that bring together the transcription start site and transcription termination site of induced

51 at CpG sites near the primary transcription start site and within exon 2 partially mediate the effec

52 hment of Lin28A binding around transcription start sites and a positive correlation between its genom

53 wed an increased distance to transcriptional start sites and accessible chromatin of the host genome

54 KChIP mRNAs contain multiple start sites and alternative exons that generate consider

55 natural selection around their transcription start sites and are enriched for cis-regulatory control.

56 oned immediately downstream of transcription start sites and at different densities across chromosome

57 amma-retroviral integration to transcription start sites and enhancers through bimodal interaction wi

58 Also, within genes, start sites and exon usage can be highly differential, p

59 We also identified transcriptional start sites and other putative regulatory regions that a

60 model in which MuvB binds near transcription start sites and plays a role in positioning downstream n

61 und to dap160 and endophilin B transcription start sites and promoters in whole nervous systems and i

62 ssociated with a longer pol II dwell time at start sites and reduced transcriptional polarity because

63 tably expands the catalogue of transcription start sites and termination sites, defines unique transc

64 ative splicing, and multiple transcriptional start sites and termination sites; while at the translat

65 rine nucleotides at eukaryotic transcription start sites and the correlation between metabolite level

66 to accumulation of H3K9me3 on transcription start sites and the corresponding downregulation of expr

67 creased distance from active transcriptional start sites and to accessible chromatin regions.

68 eosome-depleted regions around transcription start sites and transcription termination sites.

69 e-induced H3 K9 acetylation at transcription starting site and enhancer regions.

70 00 bases upstream of the CEBPA transcription start site, and demonstrated through mutational analysis

71 250 base pairs from the HSF1 transcriptional start site, and electrophoretic mobility shift and ChIP

72 ly localizes downstream of the transcription start site, and if H2A.Z is already present downstream,

73 due to differences around the transcription start site, and that its expression is repressed by down

74 protein CEBPZ present at the transcriptional start site, and this is required for recruitment of METT

75 servations when using H3K4me3, transcription start sites, and RNA polymerase II to represent the mass

76 ing reads, their enrichment at transcription start sites, and transcription factor footprint analyses

77 etermined total RNA abundance, transcription start sites, and transcription termination sites at sing

78 SNPs in promoter regions or transcriptional start sites; and 12 involving potential functional impai

79 activity, and distance to the transcription start site are features of dose-sensitive CUX1 transcrip

80 Transcription start sites are also binding sites of Origin Recognition

81 The majority of transcription start sites are associated with distal or inter-chromoso

82 Species-specific TE-derived transcription start sites are found to drive the expression of tissue-

83 s select start sites correctly, arguing that start sites are hard-wired for initiation through the ac

84 tend downstream of annotated transcriptional start sites are nevertheless bound by non-nucleosomal or

85 , HIV-1-induced ERVs harboring transcription start sites are primarily found in the vicinity of immun

86 dels and find that gene-distal transcription start sites are robust predictors of active enhancers wi

87 nd nucleosome positioning near transcription start sites, as well as a reversal of exposure-induced c

88 CG to 5hmCG within 2 kb of the transcription start site associates with distinct functions depending

89 vel ASVs from an alternative transcriptional start site (ATSS) of the MBP gene as well as a never bef

90 that ASFV utilizes alternative transcription start sites between early and late stages of infection a

91 seldom found at promoters and transcription start sites, but they are found more at enhancers, parti

92 tiated at internal in-frame and out-of-frame start sites, can be functionally important and contribut

93 t genes, nearby genes, nearest transcription start site, chromosome fragile sites, CpG islands, viral

94 and chromatin gave patterns of transcription start sites closely similar to those occurring in vivo,

95 Backtracking is most frequent within 2 kb of start sites, consistent with slow elongation early in tr

96 the 70 bp upstream of the AT2R transcription start site contain a core promoter region, and regions u

97 ns, we find that the mutant ribosomes select start sites correctly, arguing that start sites are hard

98 CpG hypomethylation at the HLF transcription start site correlated with high HLF mRNA expression, whi

99 Two cti transcriptional start sites (cti-279 and cti-77) were identified with ct

100 exons consistent with existing transcription start site data.

101 Annotation of 1625 transcriptional start sites defines transcription units for most protein

102 striking enrichment of PAR at transcription start sites, depletion of heterochromatin and downregula

103 ome occluding the TATA box and transcription start sites did not impede transcription but rather, enh

104 t that the probability of using a particular start site differs among mRNA molecules and can be dynam

105 ere in closer proximity to the transcription start site (distance: 542 bp) than to the start codon (d

106 ccurs primarily from alternative translation start sites downstream of the stop codon.

107 ng complex (APC/C) to specific transcription start sites during mitosis.

108 repositioned and occupy at least a subset of start sites during mitosis.

109 Follow-up for the latest-starting sites ended on April 1, 2014.

110 hyperacetylated nucleosomes at transcription start sites establish a chromatin landscape that facilit

111 e of epigenetic marks at their transcription start sites, evolutionary conservation among other schis

112 ng nearly 2 kb upstream of the transcription start site for 68 alleles from 57 major lineages of clas

113 5' RACE indicates a transcription start site for HYDIN2 outside of the duplication and we

114 of methylation signals around transcription start site for predicting gene expression, and increased

115 Zap1-mediated changes in the transcriptional start site for RTC4 and the production of a RTC4 transcr

116 of nucleosomes surrounding the transcription start site for silent and actively transcribed genes, at

117 ng sites enriched toward the transcriptional start sites for both induced and repressed genes.

118 rresponding to the alternate transcriptional start sites for tp53 and mdm2 were preferentially expres

119 T1 (TET1ALT) that has a unique transcription start site from an alternate promoter in intron 2, yield

120 q peaks for a given protein or transcription start sites from known gene models.

121 n the promoter and the hCD39 transcriptional start site, generating a mouse in which the expression o

122 nals were located further from transcription start sites, had smaller effect sizes, and were less enr

123 nome-wide mapping of alternative translation start sites has been unattainable.

124 ypomethylated intervals around transcription start sites have evolved to be considerably wider in pri

125 nces upstream of Ccnd2 and Myc transcription start sites implicating both as direct SMAD3 targets.

126 lie within 3 kb upstream of a transcription start site in all species.

127 is translated from a non-canonical CUG (Leu) start site in Exon 3, a site that coincides with an AUG

128 1)A antibody maps sites to the transcription-start site in mRNA 5'UTRs.

129 rikingly, it also revealed putative internal start sites in a number of Escherichia coli genes.

130 seq) method that digitally counts transcript start sites in a strand- and isoform-specific manner.

131 ve chromatin, is enriched near transcription start sites in all eukaryotes.

132 or biased distribution towards transcription start sites in the promoters of co-expressed genes.

133 8000 bp flanking the predicted transcription start sites in Xenopus tropicalis for genome wide identi

134 iched upstream of the KIAA0319 transcription start site, in both zebrafish and humans.

135 expression of an alternative transcriptional start site, including AKT3 The novel AKT3 transcriptiona

136 colocalization of histones and transcription start sites indicate chromatin regulation of transcripti

137 nthesis and degradation at the transcription start site level, characterizing the impact of different

138 referential integration near transcriptional start sites, like gammaretroviruses.

139 ly positioned nucleosomes near transcription start sites likely represent different states of promote

140 Use of alternative transcription start sites located within the Arabidopsis (Arabidopsis

141 0 kbp upstream of the IL-1beta transcription start site), marked by nucleosome depletion, enhancer-pr

142 The resulting accumulation of reads at the start site may be especially useful for detecting weakly

143 The internal start sites may also play regulatory roles in gene expre

144 ide identification of microRNA transcription start sites (miRNA TSSs) is essential for understanding

145 wnstream of annotated ORFs, from alternative start sites nested within annotated ORFs and from RNAs p

146 s, CisMapper can predict which transcription start site of a gene is regulated by a particular bindin

147 also show that an alternative transcription start site of a known plastidial enzyme produces a funct

148 Brahma, its recruitment to the transcription start site of activated genes and developmental enhancer

149 physically interacts with the transcription start site of ARID5B, that alleles of rs7090445 have dif

150 element 47 kb upstream of the transcription start site of c-Myc-interacting CDCA7L.

151 egion 6 kb downstream of the transcriptional start site of Cebpe in murine myeloid cells.

152 hat BRD4 is recruited to the transcriptional start site of differentiation-induced genes.

153 referentially initiates at the transcription start site of genes occupied by high levels of RNA polym

154 nsposons was inserted near the transcription start site of genes.

155 nd a CpG island spanning the transcriptional start site of LTF is hypermethylated in prostate cancer

156 over, two CpG islands near the transcription start site of MYBL1 were identified, and O-GlcNAc levels

157 leosome depleted region at the transcription start site of pol III genes extends past the termination

158 to mutate CTCF-binding sites at the putative start site of TERRA transcripts for a class of subtelome

159 3K4) in the chromatin around the translation start site of the gene.

160 activator of transcription 3, and a putative start site of the human mIndy promoter was determined.

161 d about 170 kb upstream of the transcription start site of the major transcript for the CADM2 gene, b

162 This region contained the transcriptional start site of the most highly expressed CD16a isoform in

163 41 kilobases downstream of the transcription start site of the transcription factor Irf8 (+41-kb Irf8

164 nd disassembly as Pol II moves away from the start site of transcription and transitions into elongat

165 ceptibility regions with the transcriptional start sites of 304 target genes.

166 s is selectively targeted near transcription start sites of a small group of genes and that most H3NT

167 romatin and localizes to the transcriptional start sites of active genes.

168 e chromatin landscape at the transcriptional start sites of B-cell- and T-cell-specific factors.

169 iments show that MCM2 binds to transcription start sites of cilia inhibiting genes.

170 BP1 predominantly binds to the transcription start sites of DNFA genes, regulating their expression b

171 le TEs are found to create the transcription start sites of downstream genes in mouse, including 117

172 Around the transcription start sites of endo-MEGs, DNA methylation and H3K4me3 sp

173 ine clusters surrounding the transcriptional start sites of expressed genes; its distribution was inv

174 are localized proximal to the transcription start sites of genes, allowing transcription initiation

175 a maximum frequency around the transcription start sites of genes.

176 RNF2 and SALL4 together occupy transcription start sites of germline genes in the stem cell populatio

177 preferentially located around transcription start sites of highly transcribed and paused genes and t

178 Histone marks around transcription start sites of HSV-1-induced and constitutively transcri

179 ce of Grh-binding sites to the transcription start sites of its targets.

180 The transcription start sites of lncRNA gene loci tend to be close to thei

181 tly around 50-500 kbs from the transcription start sites of their nearby genes, and were closely loca

182 ls of 5-hydroxymethylcytosine (5hmC) at exon start sites of upregulated genes, notably axon guidance

183 anscriptional repressor to the transcription start-site of target genes.

184 et-site, which overlaps with the translation start-site of the transcript.

185 n, the first two exons and the transcription starting site of ABCA12.

186 bout 450 bp (upstream of their transcription start site) of the analyzed C(4) Ppc promoters contain a

187 5 is recruited proximal to the transcription start site on the majority of transcription units, while

188 oring gene, likely by deleting transcription start sites on the anti-sense strand of the Gpr27 coding

189 tial utilization of distinct transcriptional start sites on the Ralpha2 promoter.

190 tion reveals two alternative transcriptional start sites, one of which is exclusive to heat stress.

191 ides (nt) upstream of the TERT transcription start site, predominantly in the opposite transcriptiona

192 L is linked to an unannotated alternate MFN2 start site preferentially expressed in platelets.

193 .Z.2 can replace each other at Transcription Start Sites, providing a molecular explanation for this

194 ts in accumulation of RNAP2 at transcription start sites, reduced gene expression, and inhibition of

195 rimethylation (H3K4me3) at the transcription start site regions of the compensatory genes.

196 In contrast, transcription start sites remain accessible in prometaphase, although

197 3), and downstream of the HSP1 transcription start site required for maximal yield.

198 Nase H1 (rnh1) has alternative translational start sites, resulting in two polypeptides, targeted to

199 The analysis of 7678 focused transcription start sites revealed 40% with a perfect match to the Inr

200 nucleotides downstream of the transcription start site reveals a novel type of eukaryotic gene regul

201 motes 48S preinitiation complex assembly and start-site scanning of 5' untranslated regions of mRNAs.

202 study provides key insights into translation start site selection heterogeneity and provides a powerf

203 We find that start site selection is largely stochastic but that the

204 driven by distinct translation start sites, start site selection of individual ribosomes can be visu

205 egulation results from altered transcription start site selection.

206 key regulatory steps of translation such as start-site selection and the coupling of transcription a

207 ons produces ribosomes defective in accurate start-site selection.

208 t protein indicated that for five genes, the start site shift likely has little effect on protein syn

209 the region downstream from the transcription start site, shows conspicuous clustering of sites with a

210 discovery of essential roles for an internal start site (SpaO) and small RNA (InvR).

211 al diversity of cap-associated transcription start sites, splicing events, poly(A) site choice and po

212 frames, each driven by distinct translation start sites, start site selection of individual ribosome

213 Our analysis of foraging's transcription start sites, termination sites, and splicing patterns us

214 e significantly closer to gene transcription start sites than nonclustered CTCF sites, suggesting tha

215 closely located to viral gene transcription start sites than would be expected by chance.

216 n 1.1 kb upstream of the CK5 transcriptional start site that is necessary for P4 activation and conta

217 single KLF site near the EphA5 transcription start site that is required for KLF16 transactivation.

218 ion, including the gain of new transcription start sites that were sometimes within protein-coding se

219 motif downstream of the cagA transcriptional start site (the +59 motif) is associated with both high

220 when positioned downstream of transcription start site, the orientation of potential G4 forming sequ

221 t when targeted far from the transcriptional start site, thereby allowing high-resolution dissection

222 enomic region 3' of the Nkx3.1 transcription start site to be responsible for alterations in Nkx3.1 e

223 1beta promoter upstream of the transcription start site to stabilize their gene transcription.

224 ed regions of DNA, but acts at transcription start sites to attenuate transcriptional initiation.

225 gets more than 10,000 lncRNA transcriptional start sites to identify noncoding loci that influence a

226 , Nup98 binds predominantly to transcription start sites to recruit the Wdr82-Set1A/COMPASS (complex

227 dy, we developed mirSTP (mirna transcription Start sites Tracking Program), a probabilistic model for

228 By mapping global transcription start site (TSS) and chromatin dynamics, we observed the

229 S location with respect to the transcription start site (TSS) and strand of occupancy (coding versus

230 oximal region relative to KLF9 transcription start site (TSS) and two occurred at distal sites.

231 ses and the incorporation of Transcriptional Start Site (TSS) annotations from RIKEN's FANTOM 5 initi

232 The transcription start site (TSS) determines the length and composition o

233 ng sites exist near the gene's transcription start site (TSS) in human but not mouse adipocytes.

234 ymerase II (Pol II) pausing at transcription start site (TSS) is one of the key rate-limiting steps i

235 Transcription start site (TSS) mapping indicates that TBPL2 has a stro

236 rent positions surrounding the transcription start site (TSS) of a reporter gene fusion in Arabidopsi

237 egion +38/+187 relative to the transcription start site (TSS) of the GM2-synthase gene than in normal

238 ac, and H3K4me3 at hundreds of transcription start site (TSS) regions and remote regulatory sites.

239 mechanisms underlying specific transcription start site (TSS) selection in mammals remain unclear.

240 Variations in transcription start site (TSS) selection reflect diversity of preiniti

241 are DNA sequences flanking the transcription start site (TSS) that help direct the proper initiation

242 ription, we investigated their transcription start site (TSS) usage, chromatin organization, and post

243 lines to measure changes in transcriptional start site (TSS) usage, identifying thousands of genetic

244 of repressive H3K9me3 at the transcriptional start site (TSS) with methylation-associated, tumor-spec

245 er region distal from the Igf1 transcription start site (TSS) with multiple E2-dependent ERalpha-bind

246 ave a functional CARE near the transcription start site (TSS), but for others the CARE is downstream.

247 stretch of DNA surrounding the transcription start site (TSS), is a major integration-point for regul

248 ad, and can occur close to the transcription start site (TSS), or within the gene body.

249 lobase-long region, called the transcription start site (TSS), which is upstream of the first protein

250 CTCF-binding site (CBS) and a transcription start site (TSS)-into 16 ectopic loci across 11 chromoso

251 ginal identity as promoter- or transcription start site (TSS)-nucleosomes.

252 However, TC-NER on the transcription start site (TSS)-proximal half of the +1 nucleosome is l

253 ssary for determination of the Transcription Start Site (TSS).

254 ocated downstream from SALL4 transcriptional start site (TSS).

255 ription bubble,' and selects a transcription start site (TSS).

256 g of RNA Pol II at the Ankrd26 Transcription Start Site (TSS).

257 and nucleotide to serve as the transcription start site (TSS).

258 ne 27 acetylation (H3K27ac) at transcription start sites (TSS) and super-enhancers (SEs) prominently

259 The differences in transcription start sites (TSS) and transcription end sites (TES) amon

260 NA polymerase (Pol) II locates transcription start sites (TSS) at TATA-containing promoters by scanni

261 Transcription start sites (TSS) in eukaryotes are characterized by a n

262 sposon inserts proximal to the transcription start sites (TSS) of genes transcribed by RNA polymerase

263 ses in part through changes in transcription start sites (TSS) or cleavage and polyadenylation sites

264 n components),transcription at transcription start sites (TSS), and the number of CCCTC-binding facto

265 imary 5' ends corresponding to transcription start sites (TSS), as well as 1628 processed 5' ends and

266 ry construction by analysing transcriptional start sites (TSS), CRISRPi identified 92% of core cell e

267 hat either create or disrupt transcriptional start sites (TSS).

268 Transcription start-site (TSS) selection and alternative promoter (AP)

269 -6 position relative to the transcriptional start site Tssr 40273; a T at this position in the BALB

270 ucture-prone sites overlapping transcription start sites (TSSs) and CCCTC-binding factor (CTCF) bindi

271 thylated DMCs were enriched at transcription start sites (TSSs) and in CpG islands, and depleted in t

272 promoters are associated with transcription start sites (TSSs) and validate novel RNA transcripts us

273 generated quantitative maps of transcription start sites (TSSs) at a single-nucleotide resolution for

274 r complexes, we identify ~2900 transcription start sites (TSSs) from within pc genes that produce exo

275 A distinct way of locating transcription start sites (TSSs) has been identified in a budding yeas

276 Accurate mapping of transcription start sites (TSSs) is key for understanding transcriptio

277 is associated with gain of new transcription start sites (TSSs) nearby and increased gene expression.

278 as starting material to detect transcription start sites (TSSs) of both stable and unstable RNAs at s

279 -R-loops sharply peaked around transcription start sites (TSSs), and these peak levels corresponded p

280 xposes enhancers to new target transcription start sites (TSSs).

281 ion that one gene has multiple transcription start sites (TSSs).

282 mRNA isoforms with alternative transcription start sites (TSSs).

283 e-depleted regions upstream of transcription start sites (TSSs).

284 some cases mutually exclusive transcription start sites (TSSs).

285 is relationship are changes in transcription start sites (TSSs).

286 tic promoters utilize multiple transcription start sites (TSSs).

287 Heterogeneous transcriptional start site usage by HIV-1 produces 5'-capped RNAs beginn

288 wnstream sequences relative to transcription start site usage suggested that ACA and CNAAATT motifs a

289 precisely delineated by active transcription start sites, validate that these boundaries are sufficie

290 lysis showed that the MITF-A transcriptional start site was highly enriched with H3K27ac marks.

291 An active secondary transcription start site was identified within the intergenic region o

292 ome position downstream of the transcription start site, we identified unwrapped intermediates, inclu

293 observed within 1 kb from the transcription start site, where both histone H3 methylation marks co-o

294 t position +27 relative to the transcription start site, whereas most complexes had completed promote

295 trong Set1 enrichment near the transcription start site, whereas Set2 was distributed along pre-mRNAs

296 in repressed regions and near transcription start sites, whereas the genetically regulated CpGs are

297 precise determination of 2659 transcription start sites which reveal transcriptional and translation

298 ucleotides downstream of the transcriptional start site, while beta genes bore Pol II more evenly acr

299 ariant by activating a cryptic transcription start site within LTR12C.

300 antisense RNAs that arise from transcription start sites within parts of the genome encoding 3'-untra