ライフサイエンスコーパス: starting point

1 on and subsequent retrievals (retrieval as a starting point).

2 outward path, allowing direct return to the starting point.

3 he evidence accumulation, rather than in its starting point.

4 dged by approaches that leverage mRNA as the starting point.

5 omplished from Garner's aldehyde as a common starting point.

6 as known FK1 binder and provide new chemical starting points.

7 subsequently expanding over 500 km from its starting point [7-11].

8 Using the identified compounds as a starting point a substructure directed search against CH

9 cumulated in this review can serve as both a starting point and a complete reference material for det

10 GEMM models using common melanoma GEMMs as a starting point and added additional CRISPR, Cre-inducibl

11 from simple; however, this paper provides a starting point and basic principles to facilitate discus

12 tiple possible goal locations from different starting points and via multiple routes.

13 ct on determining neonatal shark contaminant starting points, and trophic ecology and physiology may

14 steine to identify FGFR4 selective inhibitor starting points are summarized which made use of both ra

15 Finally, using metamapping as a starting point can dramatically accelerate later learnin

16 tis sp. PCC 6803 (Synechocystis 6803) as the starting point encompassing 593 reactions.

17 it further makes these techniques a valuable starting point for a bottom-up approach in understanding

18 er positive-strand RNA viruses and provide a starting point for a comprehensive analysis of critical

19 erity, level of control and phenotype is the starting point for a comprehensive treatment strategy.

20 mone receptor 1 (MCHr1) antagonists were the starting point for a drug discovery program that culmina

21 target protein, can be an effective chemical starting point for a drug discovery project.

22 lizing the simple benzofuran template 7 as a starting point for a fragment growing approach was pursu

23 s syndrome to identify an appropriate dosage starting point for a future efficacy trial using a pharm

24 ist of 32 potentially relevant items was the starting point for a modified Delphi procedure involving

25 We anticipate our research to be a starting point for a more comprehensive evaluation invol

26 Such, this contribution may serve as a starting point for a more detailed investigation of the

27 We anticipate that our findings will be a starting point for a more sophisticated understanding of

28 The peptides therefore represent a promising starting point for a new class of substrate-competitive

29 This serves as a starting point for a new generation of chemical separati

30 ncentrations in rats, providing an excellent starting point for a proof-of-principle study.

31 itself represents a poor medicinal chemistry starting point for a selective, cell-active inhibitor gi

32 agment hit 1,2,3-triazole 7 as an attractive starting point for a structure-based drug design hit-to-

33 of the zirconium catalyst and serves as the starting point for a theoretical study of the catalytic

34 We suggest that the LLPS model provides the starting point for a unifying quantitative framework for

35 Taken together, necrosis represents the starting point for a vicious cycle including the uptake

36 and computational modeling can serve as the starting point for additional antibody reengineering (e.

37 ically on the homopolymerization of TFE (the starting point for all fluoropolymer industries), it wil

38 slope-to-amplitude ratio (TS/A) was used as starting point for an ECG-based [K(+)] estimate (KECG).

39 DCP3 is intended to be a model starting point for analyses at the country level, but co

40 This work is a starting point for analysing skin and other heterogeneou

41 metabolite (+)-pleuromutilin has served as a starting point for antibiotic development.

42 The quality framework developed can be the starting point for any Total Diet Study centre and can b

43 Our results provide a starting point for broader quantitative analyses of scie

44 tained from these screens suggest they are a starting point for chemical modifications with potential

45 inesia pathophysiology will serve as the new starting point for clinical and experimental purposes.

46 ncer Institute remains rightly viewed as the starting point for clinical PDT in modern medicine.

47 ccf-nDNA recovery and serves as an important starting point for clinical studies.

48 The findings are an important starting point for clinicians considering the introducti

49 ling may invalidate the standard single-site starting point for considering magnetism, and can lead t

50 omic deprivation, and obesity, but provide a starting point for considering the number of individuals

51 The outcome of the algorithm serves as a starting point for correction methods.

52 EUHC) with 218 interventions that provides a starting point for country-specific analysis of prioriti

53 These findings provide a starting point for creating mechanistic framework of bra

54 biosynthesis in M. pulcherrima and provide a starting point for deciphering the molecular functions u

55 omic-level view of the azole synthetase is a starting point for deeper understanding and control of b

56 Arevalo et al. (2019) use this as a starting point for defining ecologically-relevant popula

57 (2019) use this as a starting point for defining ecologically-relevant popula

58 archenteron elongation and provides a useful starting point for designing future experiments to exami

59 molecular skeleton were explored as a viable starting point for designing new anti-glioblastoma drug

60 These findings provide an important starting point for developing nonhuman primate models to

61 d red blood cells and potentially provides a starting point for developing novel strategies to preven

62 Together, these studies represent a starting point for developing structure-based drug-desig

63 s identified here can potentially serve as a starting point for development of GluD2-selective ligand

64 thal concentrations, hence providing a novel starting point for discovery of custom designed engineer

65 The outputs were assembled and used as the starting point for discussions occurring at a subsequent

66 incamine, an indole alkaloid, as a synthetic starting point for dramatic structural alterations of it

67 present four options for finding a chemical starting point for drug discovery projects: screening li

68 Such information can also provide a starting point for drug discovery.

69 These structures provide an essential starting point for elucidating the complex gating mechan

70 connectivity (FC) methods-are likely a good starting point for estimating brain network interactions

71 In doing so, we provide a suitable starting point for expansions of AMS interventions in th

72 rs for helicases, and 9 could be a promising starting point for exploring molecular probes to elucida

73 n enzyme orthosteric sites offers a rational starting point for FBDD.

74 y-based considerations comprise an important starting point for formulating clinical management pathw

75 of isoquinoline ethyl urea 13 as a promising starting point for fragment evolution.

76 We anticipate our study to be a starting point for further and more sophisticated invest

77 DiB-splits also represent an attractive starting point for further design of a protein-protein i

78 We anticipate these findings to be a starting point for further exploration of molecular cata

79 The hypotheses we generated may serve as a starting point for further functional studies in this re

80 ble, make this new class of molecules a good starting point for further in vivo studies.

81 Our results serve as a starting point for further investigations on how a type

82 It may also be used as a starting point for further numerical optimization algori

83 Nevertheless, 1a served as a starting point for further optimization.

84 ient-derived xenograft models and provides a starting point for further pharmacokinetic/dynamic optim

85 tes near the Fermi edge, which was used as a starting point for further selection of suitable MOFs.

86 pted to other imaging modalities and forms a starting point for further steps of data analytics and m

87 tially explicit data set may also serve as a starting point for further studies aiming at determining

88 rine life in the water column to establish a starting point for further study into ecosystem impact.

89 mg/m(2)/day of miransertib is an appropriate starting point for future efficacy trials and that this

90 ed between hsNadE and tbNadE provides also a starting point for future efforts in the development of

91 use and human microsomes and provides a good starting point for future efforts.

92 upport for multiple hypotheses should be the starting point for future FLS analyses.

93 These results may provide an alternative starting point for future investigations into unconsciou

94 Our engineered strain constitutes a starting point for future optimization efforts towards r

95 This study will serve as a starting point for future research on osmotic stress res

96 This dataset provides a solid starting point for future studies addressing key element

97 ta, and including essential genes, will be a starting point for future work examining how different d

98 lation within the spinal cord constitute the starting point for handedness, implying a fundamental sh

99 r synergy model, deeming them as a promising starting point for hit-to-lead development.

100 bility versus resilience to stress provide a starting point for in vivo models of mechanisms predispo

101 The starting point for including such information is the qua

102 on during tissue or organ progression, and a starting point for investigating regulatory elements tha

103 r a warmer climate, this work may serve as a starting point for investigating socioeconomic factors o

104 This knowledge provides a starting point for investigations into the role of speci

105 This review was designed to serve as a starting point for investigators wishing to use PRSs in

106 onomically verified dataset provides a valid starting point for macroecological and evolutionary stud

107 ecognition of protein structural fold is the starting point for many structure prediction tools and p

108 s structural data for BLV Gag and could be a starting point for modeling Gag-small molecule interacti

109 The Hubbard model represents a minimal starting point for modeling strongly correlated systems.

110 We anticipate our study to be a starting point for more extensive studies on ancient ani

111 sider including the 32 shared variables as a starting point for more policy- and practice-relevant re

112 calculate key quantities, making it a useful starting point for more realistic models.

113 , and we hope that this manuscript will be a starting point for more research work on fossil evidence

114 anticipate that the present work serves as a starting point for more sophisticated and detailed studi

115 We anticipate our findings will be a starting point for more sophisticated non-intrusive pati

116 small-scale exploratory study may serve as a starting point for nephrologists seeking to improve on p

117 This work defines the starting point for new biofilm/lectin-targeted drugs to

118 gh this half-strip LFA may serve as a useful starting point for others developing similar tests.

119 one core and a JAK1 bias was selected as the starting point for our fragment-based lead generation ef

120 l fishing effort resulted in an impoverished starting point for PIPA equivalent to 1.5 y of banned fi

121 e and dementia and potentially may provide a starting point for prevention and treatment.

122 These results may provide a starting point for prioritising interactions for conserv

123 This work provides a starting point for probing and enhancing protein functio

124 dation profiles of the compounds; thus, as a starting point for PROTAC development, both the target l

125 stimulated this development as a conceptual starting point for rational catalyst design.

126 nalyses are important because they provide a starting point for rationally tuning the thermodynamics

127 been characterized and our results provide a starting point for refining the physical models of the c

128 eir importance for OsMTP11 function and is a starting point for refining transporter activity/specifi

129 This document forms a starting point for research aiming to develop evidence-b

130 Our findings may provide a starting point for research using data from social media

131 However, health provides a critical starting point for scaling up, given its reach to pregna

132 cales of ~100 kB to 15 MB, offering an ideal starting point for small experiments.

133 ere, we argue that algorithms provide a good starting point for studies of natural behavior more gene

134 Taken together, these results provide a starting point for studying the implications of WDR prot

135 This optimized hit provides an ideal starting point for subsequent hit-to-lead campaigns prov

136 inhibitors of Plasmodium NMT and serve as a starting point for subsequent medicinal chemistry effort

137 ants of plant root colonization and offers a starting point for targeted improvement of the colonizat

138 Our results provide a starting point for technologies enabling direct, rapid,

139 ssing and cell biology fields that provide a starting point for testing this hypothesis.

140 The results provide a starting point for the broader use of 2-aza-Cope reactiv

141 s multiscale characterization can serve as a starting point for the building of robust and mechanisti

142 "chiral pool terpenes") has long served as a starting point for the chemical synthesis of complex nat

143 tin functions should serve as a resource and starting point for the chromatin and cancer biology fiel

144 These motifs are a promising starting point for the construction of artificial protei

145 of the previously reported DDD85646 (1) as a starting point for the design of a class of potent, brai

146 ng at the catalytic site of hRRM1 provides a starting point for the design of a unique class of hRR i

147 We envision this to be a starting point for the design of many types of reversibl

148 diovascular side effects, make 3b a valuable starting point for the design of novel antagonists poten

149 o IgE-FcepsilonRI complexes, and represent a starting point for the design of promising hypoallergens

150 2 diabetes mellitus, as well as a promising starting point for the design of structural analogs with

151 This work provides a starting point for the design of systems that exploit me

152 g a urea zinc-binding motif were used as the starting point for the development of a novel class of h

153 Our findings represent a starting point for the development of a prognostic test

154 ions of N1-Src and C-Src in neurons and is a starting point for the development of a small molecule i

155 oach addressing beer traceability and is the starting point for the development of a standardized pro

156 2,4-oxazolidinediones appear to be a viable starting point for the development of an alternative cla

157 that Evasin-4 derivatives could be used as a starting point for the development of anti-inflammatory

158 ine inhibitor of RSK kinases, as a promising starting point for the development of chemical probes ta

159 Apelin-36-[L28C(30kDa-PEG)] provides a starting point for the development of diabetes therapeut

160 On the other hand, it may serve as starting point for the development of dual targeting lig

161 nto the reactivation mechanism and provide a starting point for the development of improved antidotes

162 of the x-ray crystal structures, provides a starting point for the development of more potent molecu

163 l, compound 7h is represented as a promising starting point for the development of new anti-colorecta

164 odels combine to make apramycin an excellent starting point for the development of next-generation am

165 Synthesized compounds represent a promising starting point for the development of novel antithrombot

166 uggest that gladiolin may represent a useful starting point for the development of novel drugs to tac

167 CAY represents a very valuable starting point for the development of novel wound-healin

168 cterial culture broth extracts have been the starting point for the development of numerous therapeut

169 amino acid sequence and by this, serve as a starting point for the development of peptide-based inhi

170 identifies a promising MMP-14 inhibitor as a starting point for the development of protein-based anti

171 esults indicate this scaffold is a promising starting point for the development of selective antichla

172 Our findings constitute a novel starting point for the development of selective ERAP1 mo

173 RANKL-selective inhibitors are an excellent starting point for the development of small-molecule the

174 Our results provide a starting point for the development of Spt14 inhibitors f

175 flatworm temporary adhesion may serve as the starting point for the development of synthetic reversib

176 elay hIAPP aggregation in vitro, providing a starting point for the development of T2D therapeutics a

177 Compound D11 may serve as a promising starting point for the development of therapeutics to tr

178 the 2A(pro) from EV-D68 and can be used as a starting point for the development of therapeutics with

179 on and point to the BTZ scaffold as a useful starting point for the discovery of allosteric MGL inhib

180 haracterization and can serve as a promising starting point for the discovery of new antimelanoma the

181 ical pollination syndromes, but provided the starting point for the evolution of a novel set of disti

182 Our framework should provide a good starting point for the more detailed analysis of policie

183 e that ODC1 gene hypermethylation could be a starting point for the onset of genome-wide epigenetic a

184 Our model is an important starting point for the predictive modeling of cell fate

185 Our results present a starting point for the rational design of lead halide pe

186 We anticipate our discovery to be a fresh starting point for the study on the roles of MOCOS in br

187 factor receptor inhibitor, was explored as a starting point for the synthesis of new hits against Try

188 sociated regions should provide an important starting point for the translational community in search

189 The starting point for the workshop was the recent reports f

190 tin polymerization and limits tetraploidy, a starting point for tumorigenesis.

191 chiral coiled-coil dimers, which represent a starting point for understanding associations of l- and

192 modification and is therefore an attractive starting point for understanding control of Tau's inhibi

193 ive inference framework offers an attractive starting point for understanding cultural cognition.

194 they believe this study provides a critical starting point for understanding how to optimize the vir

195 e "Immediate Early Gene" (IEG) response, the starting point for understanding the gAP.

196 These insights also provide a starting point for understanding the types of subsequent

197 nofibers to enable adhesion, and serves as a starting point for unraveling the molecular architecture

198 ase protein targets and potentially serve as starting points for a new therapeutic approach to the tr

199 molecules from this study serve as candidate starting points for CDI drug development and provide new

200 encouraged to pursue these as drug discovery starting points for COVID-19.

201 that can serve as pharmacological probes or starting points for developing CNS-active Keap1 inhibito

202 activities represent potentially attractive starting points for divergent evolution in the laborator

203 olecules identified here represent potential starting points for DMD drug discovery efforts.

204 ordinary selectivity profiles make excellent starting points for drug development.

205 olded proteins, such ensembles are excellent starting points for further refinement with additional e

206 yields of these clusters render them perfect starting points for further research.

207 metabolic stability, thus offering excellent starting points for further therapeutic development.

208 that the molecules disclosed can be used as starting points for future efforts toward compounds with

209 Our results may serve as useful starting points for future therapeutic intervention appr

210 ousands to millions of molecules to identify starting points for medicinal chemistry.

211 chance of success when seeking new chemical starting points for novel and less-tractable targets.

212 their parent institutions, making them good starting points for our initial efforts to promote the d

213 Starting points for our optimization efforts with the go

214 These hyperstable minibinders provide starting points for SARS-CoV-2 therapeutics.

215 insight and are expected to represent useful starting points for searches by more advanced methods.

216 Finally, we suggest good starting points for self-learning and hope to convince r

217 To identify starting points for such therapeutics, we performed a la

218 h dual asexual/sexual activity, representing starting points for target identification and candidate

219 ggesting that such proteins may be excellent starting points for the development of customized biocat

220 tagonists and may be considered as promising starting points for the development of new therapeutic a

221 tools for probing MYC function and serve as starting points for the development of novel anti-MYC th

222 ed approach can be used to identify chemical starting points for the development of small-molecule st

223 nner with fragments that represent promising starting points for the development of specific 14-3-3 P

224 entify fragment molecules that will serve as starting points for the development of tankyrase substra

225 enzymatic source of cAMP production, are key starting points for understanding cAMP compartments and

226 This article represents a starting point from which diagnostic and management deci

227 k aromatic compounds are compelling low-cost starting points from which molecular complexity can be g

228 The starting point in the exercise is the one-dimensional (1

229 s vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies w

230 wide association (GWA) studies can provide a starting point in the search for novel drug targets and

231 hey cannot proceed without the low-frequency starting point in their broadcasts.

232 en together, the present findings provided a starting point in understanding the effect of intestinal

233 reduces the hit rates of attractive chemical starting points in subset screening.

234 icable to novel protein targets, identifying starting points in the development of therapeutics.

235 or small molecule drug discovery, a chemical starting point is then required.

236 into B-cell clones and identification of the starting point of a B-cell clonal lineage, the initial V

237 monly assumed that choice history shifts the starting point of accumulation toward the bound reflecti

238 adjustments, as reflected by changes in the starting point of evidence accumulation, are responsible

239 This agitator represents the starting point of the allosteric signal propagation path

240 The starting point of the CGP map is a weighted network, the

241 -saccade process, in turn, helped to set the starting point of the next within-saccade process.

242 dental transmission events, 3) predating the starting point of the outbreak, 4) capturing new unsuspe

243 s with a spatial sequence, flashing only the starting point of the sequence triggers an activity wave

244 functional unit of organisms, represents the starting point of this review.

245 nsights that suggest that microfissures, the starting points of paint delamination, are the result of

246 of high-affinity ligands to serve as PROTAC starting points remains challenging.

247 et, little is known about the performance of starting points (seed nodes) for diffusion.

248 a rise-to-threshold decision process with a starting point that reflected expected state-dependent t

249 e, illustrating that fragments are versatile starting points that can be optimized to structurally di

250 Taking as a starting point the involvement of the TCA cycle in PPGL

251 We use as our starting point the Magnetic Materials Database on the Bi

252 cule in complex with a target protein as the starting point, this approach identifies attachment poin

253 gy is the generation of a library of design 'starting points' through the discovery and characterizat

254 osals enumerated here will serve as a useful starting point to address these challenges.

255 nticipate that these hybrid structures are a starting point to build integrated biological circuits a

256 Our results can also serve as a starting point to categorize GO terms into region-specif

257 Here the rat HPF flatmap was used as a starting point to construct an analogous flatmap for the

258 W. smithii provides a unique starting point to determine if there are universal nonbi

259 nd theoretical model proposed here provide a starting point to develop a comprehensive understanding

260 This scaffold represents a promising starting point to develop a new antimalarial.

261 These fragments represent a starting point to develop ALAS2 inhibitors as substrate

262 s with planar moieties represent a promising starting point to develop small-molecule therapeutics fo

263 nistic findings would pave the way for a new starting point to discover drugs for (so far) "undruggab

264 t with this review, we provide a forum and a starting point to discuss the idea that catalytic functi

265 , we use Metchnikoff's seminal lectures as a starting point to discuss the tremendous variety of cell

266 Our structure provides a starting point to establish structural parameters of the

267 The results provide a solid starting point to evaluate the effects of these loci in

268 The data presented herein may serve as a starting point to evaluate tolerance limits of metals an

269 This structure provides a starting point to exploit HIPK2's distinct structural fe

270 male germ cell biology and TLR function as a starting point to explore the mechanistic and evolutiona

271 These studies will serve as a starting point to explore the nonlinear dynamics of atri

272 these findings may represent an encouraging starting point to further expand this chemical class, ad

273 s plausible deletion precursors, providing a starting point to identify the molecular mechanisms of m

274 ors may be used in the future as a promising starting point to perform motional cooling for explorati

275 fields via improved management, providing a starting point to set priorities and inform policy.

276 ess in cancer, this work provides a valuable starting point to study broader cross-talk between metal

277 This study provides a starting point to study how RGB cone-specific transcript

278 during this form of cell death, providing a starting point to study iron signaling in living systems

279 Although RCTs may provide a useful starting point to think about bias, they do not provide

280 Our structural studies provide a starting point to understand and further study the molec

281 TRPC proteins in a mouse model and provide a starting point to understand the function of TRPC channe

282 New phytases are sought as starting points to further optimize the rate and extent

283 lations with ML, this paper can be used as a starting point toward accelerated optimization of C-S-H

284 t antigens in PAH lung immune complexes as a starting point toward resolving these issues to better i

285 as the ones presented here, provide valuable starting points toward insecticides and are complementar

286 The starting point was Lee Hartwell's 1970s landmark papers

287 Using liver biopsy as a starting point, we analyzed the development of end-stage

288 Using these priority areas as a starting point, we developed a conceptual framework of t

289 covalent kinase inhibitor (CKI) SM1-71 as a starting point, we developed covalent inhibitor 15a, whi

290 na Human BodyMap RNA sequencing dataset as a starting point, we first identified lincRNAs ubiquitousl

291 Using the X-ray crystal structure as a starting point, we have modeled the motions of a DNA dup

292 he consensus substrate-peptide sequence as a starting point, we optimized the length and rigidity of

293 g the policy learned from the moth data as a starting point, we propose an actor-critic learning algo

294 Using our work as a starting point, we propose continued development of mode

295 inhibitors to serve as alternative chemical starting points, we performed a high-throughput screen o

296 c lipid and its related metabolic enzymes as starting points, we summarize their roles within the dif

297 oughly 36 times more tightly than the design starting point (wild-type c-Raf-RBD).

298 Some of these probes represent exciting starting points with the potential to illuminate poorly

299 ormation as possible from any search and any starting point within EMBL-EBI's websites.

300 that if evolution had begun from a different starting point within the network of sequences encoding