ライフサイエンスコーパス: status epilepticus

1 fter single febrile, unprovoked seizures, or status epilepticus).

2 neuroprotective actions in rodent models of status epilepticus.

3 ocampus was active throughout the episode of status epilepticus.

4 hippocampal neuronal death in vivo following status epilepticus.

5 ility; however, it reduced susceptibility to status epilepticus.

6 d after pilocarpine- and kainic acid-induced status epilepticus.

7 out the process of epileptogenesis following status epilepticus.

8 glia following excitatory injury elicited by status epilepticus.

9 65 did not predict progression to refractory status epilepticus.

10 trongly resembles clinical EEG recordings of status epilepticus.

11 53 (29.9%); 96 cases (54.2%) were refractory status epilepticus.

12 reduced mortality, severity, and duration of status epilepticus.

13 the hippocampus of humans who died following status epilepticus.

14 cond-line drug for benzodiazepine-refractory status epilepticus.

15 psy after intra-amygdala kainic acid-induced status epilepticus.

16 rologic outcomes in patients with convulsive status epilepticus.

17 ment in auditory discrimination had incident status epilepticus.

18 ndard care alone in patients with convulsive status epilepticus.

19 s in the context of a stroke-like episode or status epilepticus.

20 patients admitted to the ICU for convulsive status epilepticus.

21 enic injuries, including pilocarpine-induced status epilepticus.

22 us epilepticus can be inhibited to terminate status epilepticus.

23 ated patients with nonprincipal diagnoses of status epilepticus.

24 patients admitted to the ICU for convulsive status epilepticus.

25 especially in patients with complex partial status epilepticus.

26 considered in the evaluation of the child in status epilepticus.

27 ic infusions to be weaned with resolution of status epilepticus.

28 considered first-line therapy for pediatric status epilepticus.

29 igh suspicion for nonconvulsive seizures and status epilepticus.

30 considered in young children with recurrent status epilepticus.

31 n 2 pediatric patients with super-refractory status epilepticus.

32 sful anaesthetic liberation after refractory status epilepticus.

33 1% had nosocomial infections diagnosed after status epilepticus.

34 the withdrawal of anaesthetics in refractory status epilepticus.

35 lectrographic seizures, or 3) electrographic status epilepticus.

36 ably well on our cohort of ICU patients with status epilepticus.

37 r the definitions of seizures, epilepsy, and status epilepticus.

38 reduced mortality, severity, and duration of status epilepticus.

39 n, and mortality observed during focal onset status epilepticus.

40 f activation in relation to the induction of status epilepticus.

41 nt in the treatment of paediatric convulsive status epilepticus.

42 ting an EEG pattern concerning for incipient status epilepticus.

43 m, and olfactory system in the initial phase status epilepticus.

44 ond-line management of paediatric convulsive status epilepticus.

45 Of 311 patients with status epilepticus, 224 patients (72%) were treated on t

46 Of 467 patients with incident status epilepticus, 238 returned to baseline (51.1%), 16

47 nding prevalence was high in post convulsive status epilepticus (33.5%, 20.2%, and 32.9%), CNS infect

48 ollment of patients with a second episode of status epilepticus accounted for 16 additional instances

49 etrospective review of adults with new-onset status epilepticus admitted to Mayo Clinic, Rochester MN

50 Our analysis demonstrates that status epilepticus after admission for sepsis in the Uni

51 FVB mice (n = 127) that had experienced status epilepticus after systemic treatment with pilocar

52 rom randomisation to cessation of convulsive status epilepticus, analysed in the modified intention-t

53 ractive shifts in neuronal activity (kainate status epilepticus and CaMKIIa Gq DREADD activation) tri

54 arpine-induced status epilepticus, and after status epilepticus and daily treatment beginning 24 hour

55 e associated with higher rates of refractory status epilepticus and death (with every 1mg/L: odds rat

56 left untreated, the disease can progress to status epilepticus and death in infancy.

57 ease progression between 2 and 5 months post-status epilepticus and drastically reduced the frequency

58 y and demonstrate that blocking P2Y(1) after status epilepticus and during epilepsy has potent antico

59 r research to enable early identification of status epilepticus and efficacy of anti-epileptic drugs

60 novel treatment strategy for drug-refractory status epilepticus and epilepsy.

61 ndidate for the treatment of drug-refractory status epilepticus and epilepsy.SIGNIFICANCE STATEMENT T

62 The primary outcome of cessation of status epilepticus and improvement in the level of consc

63 CRP at the blood-brain barrier in rats after status epilepticus and in CE rats.

64 en electrographic seizures or electrographic status epilepticus and mortality or short-term neurologi

65 Respondents continue to rely on myoclonic status epilepticus and neuroimaging, which were favored

66 evels in the contralateral hippocampus after status epilepticus and resulted in more frequent spontan

67 rence and sedation and times to cessation of status epilepticus and return to baseline mental status.

68 orn up to 5 weeks before pilocarpine-induced status epilepticus and these cells were then eliminated

69 ous anaesthesia without developing recurrent status epilepticus, and a wean failure as either recurre

70 including pain, alcohol withdrawal syndrome, status epilepticus, and acute agitation.

71 us asthmaticus, alcohol withdrawal syndrome, status epilepticus, and acute behavioral psychologic dis

72 ce, in mice 5 days after pilocarpine-induced status epilepticus, and after status epilepticus and dai

73 140 patients with encephalitis, seizures or status epilepticus, and antibodies to unknown neuropil a

74 cal ventilation for more than 24 hours after status epilepticus, and arterial hypotension requiring v

75 described as a strategy for super-refractory status epilepticus, and better evidence for their use ma

76 , fosphenytoin, and valproate in established status epilepticus, and here we describe our results aft

77 erline common EEG seizure onset patterns and status epilepticus, and postulates a role for synaptic p

78 Recommendations regarding nutrition during status epilepticus are lacking, and it is unclear whethe

79 ses of truly refractory and super-refractory status epilepticus are seen infrequently at any given in

80 The definition of status epilepticus as a prolonged seizure or a series of

81 ity during anaesthetic weaning in refractory status epilepticus as predictors of successful weaning f

82 onstandardized and age-standardized rates of status epilepticus as the underlying cause of death in t

83 -6B and HHV-7 primary infection with febrile status epilepticus as well as the role of reactivation o

84 of MRI vs. computed tomography in new-onset status epilepticus, as well as high rates of identificat

85 on locomotor rhythmogenesis and touch-evoked status epilepticus associated with markedly impaired KCC

86 rbital and midazolam significantly increased status epilepticus-associated neuronal injury in various

87 atment, and critically, that the duration of status epilepticus at the time of treatment is an import

88 trols in vehicle-treated mice 2 months after status epilepticus, but remained at only 63% of controls

89 he primary efficacy outcome was cessation of status epilepticus by 10 minutes without recurrence with

90 Finally, induction of status epilepticus by intrahippocampal injection of pilo

91 ability to accurately predict the outcome of status epilepticus by measures of discrimination and cal

92 creasing evidence suggests that seizures and status epilepticus can be immune-mediated.

93 ium-permeable AMPA receptors modified during status epilepticus can be inhibited to terminate status

94 Lastly, kainate-induced status epilepticus causes GIRK1 and GIRK2 cleavage in th

95 ing fatal etiology, duration and severity of status epilepticus, Charlson comorbidity index, and trea

96 logy, Status Epilepticus Severity Score, and status epilepticus classification per the Status Epilept

97 Loss of consciousness, status epilepticus classification, or age greater than o

98 nce was particularly high in post convulsive status epilepticus, CNS infection, and post cardiac arre

99 If status epilepticus continued at 12 minutes, fosphenytoin

100 her modified AMPA receptors generated during status epilepticus could be targeted with a drug.

101 The prognosis of convulsive status epilepticus (CSE), a common childhood medical neu

102 line received more calories and proteins per status epilepticus day, and increasing nutritional suppo

103 relative risk, 1.01; 95% CI, 1.001-1.01) per status epilepticus day, independent of potential confoun

104 s a condition characterized by recurrence of status epilepticus despite use of deep general anesthesi

105 atios of nonconvulsive seizure/nonconvulsive status epilepticus detected by continuous electroencepha

106 ither nonconvulsive seizure or nonconvulsive status epilepticus detected by routine electroencephalog

107 alizations, likely reflecting an increase in status epilepticus diagnoses through improved diagnostic

108 The history of status epilepticus, diagnosis of psychosis and positron

109 Progression to refractory status epilepticus did not impact functional outcome or

110 failures at ICU admission and occurrence of status epilepticus during ICU stay were not associated w

111 ts), and focal epilepsies with an electrical status epilepticus during slow sleep-like EEG pattern (s

112 following experimental prolonged FS (febrile status epilepticus; eFSE).

113 ence of nonconvulsive seizure, nonconvulsive status epilepticus, either nonconvulsive seizure or nonc

114 infection, seizures including non-convulsive status epilepticus, endocrinopathy, or thiamine deficien

115 lence of nonconvulsive seizure/nonconvulsive status epilepticus/epileptiform activity and odds ratio

116 o provide updates on identifying children in status epilepticus, etiologic considerations, and the ra

117 Patient demographics, status epilepticus etiology, Status Epilepticus Severity

118 ratio, 8.85; 95% CI, 4.87-16.08), myoclonic status epilepticus (false-positive rate, 0.05; 95% CI, 0

119 ecorded prospectively demographics, clinical status epilepticus features, treatment, and outcome at d

120 Cessation of status epilepticus for 10 minutes without recurrence wit

121 l patient records of all adult patients with status epilepticus from 2012 to 2018.

122 cohort of patients admitted with refractory status epilepticus from 2016 to 2019.

123 dy reviews protocols for treating convulsive status epilepticus from 33 emergency medical services sy

124 e is a long-standing hypothesis that febrile status epilepticus (FSE) can cause brain injury, particu

125 Whether febrile status epilepticus (FSE) produces hippocampal sclerosis

126 in disorder, arises in children with febrile status epilepticus (FSE).

127 coma is associated with poorer outcome after status epilepticus; furthermore, it portends higher infe

128 0 min) febrile seizures; febrile or afebrile status epilepticus (>30 min); or with clusters of two or

129 of drug-resistant epilepsies and refractory status epilepticus has been further defined and is expec

130 conditions, which in their most severe form, status epilepticus, have a high mortality rate if not qu

131 related mortality and the marked increase in status epilepticus hospitalizations, likely reflecting a

132 se drugs are administered after the onset of status epilepticus, however, their effect on seizure sev

133 tergic synaptic transmission associated with status epilepticus; however, gamma-aminobutyric acidergi

134 form activity in 209 of 374 (55%), including status epilepticus in 102 of 374 (27%).

135 IEM-1460 rapidly terminated status epilepticus in a dose-dependent manner.

136 This review discusses the management of status epilepticus in children, including both anticonvu

137 tatus epilepticus (RSE) and super-refractory status epilepticus in children.

138 irst report of allopregnanolone use to treat status epilepticus in children.

139 with generalized convulsive or nonconvulsive status epilepticus in coma.

140 with promise for prevention of TLE caused by status epilepticus in humans.

141 vestigated P2X7R responses after focal-onset status epilepticus in mice, comparing changes in the dam

142 chemoconvulsant inhibition likely aggravates status epilepticus in Orai1 KO mice.

143 a paucity of data on patients with new-onset status epilepticus in patients without a prior history o

144 ketogenic diet as treatment for uncontrolled status epilepticus in pediatric patients.

145 Using a recently developed model of status epilepticus in postnatal day 7 rat pups that resu

146 the 21-year study period, the prevalence of status epilepticus in primary admissions of septic patie

147 lsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence sug

148 We will present the current definition of status epilepticus, including a recently modified operat

149 The definition and general approach to status epilepticus, including resource use, should evolv

150 Seizure activity, in particular status epilepticus, increases cerebral amino acid transp

151 tigate a potential role of Orai1 channels in status epilepticus induced by chemoconvulsants, we exami

152 made in a well-characterized mouse model of status epilepticus-induced epilepsy (systemic pilocarpin

153 at desirable and undesirable consequences of status epilepticus-induced TrkB activation are mediated

154 Treatment with pY816 following status epilepticus inhibited TLE and prevented anxiety-l

155 sistent across two different mouse models of status epilepticus (intra-amygdala kainic acid and intra

156 Status epilepticus is a common neurologic emergency in c

157 Status epilepticus is a common neurologic emergency with

158 Status epilepticus is a common neurological emergency wi

159 Super-refractory status epilepticus is a condition characterized by recur

160 Super-refractory status epilepticus is a life-threatening condition.

161 Generalized convulsive status epilepticus is a life-threatening emergency, beca

162 Status epilepticus is also increasingly identified in th

163 Status epilepticus is an acute neurologic emergency, the

164 Status epilepticus is an emergency; however, prompt trea

165 Rapid management of status epilepticus is associated with a greater likeliho

166 Generalized convulsive status epilepticus is associated with a rapidly rising m

167 Generalized convulsive status epilepticus is associated with high mortality.

168 ; however, prompt treatment of patients with status epilepticus is challenging.

169 Status epilepticus is common in neonates and infants, an

170 Status epilepticus is defined as a state of unrelenting

171 ndicate that increased calorie intake during status epilepticus is independently associated with unfa

172 A common form of generalized convulsive status epilepticus is of focal onset.

173 Benzodiazepine-refractory, or established, status epilepticus is thought to be of similar pathophys

174 od-brain barrier pathology in rats following status epilepticus, late electrocorticography to identif

175 We then show that the persistent status epilepticus-like activity is associated with a re

176 This showed that during status epilepticus-like activity, reduced Cl- extrusion

177 arbital had a similar exacerbating effect on status epilepticus-like activity, while a high concentra

178 s epileptiform activity during this stage of status epilepticus-like activity.

179 stimulation of GABAergic interneurons in the status epilepticus-like state, actually enhanced epilept

180 Having a predetermined status epilepticus management pathway can expedite manag

181 Among 244 patients with status epilepticus (mean age was 64 yr [interquartile ra

182 ogenesis was initiated using the pilocarpine status epilepticus model in male and female mice.

183 in as seizures progressed and at the peak of status epilepticus, motor and somatosensory cortex, retr

184 annabidiol use, the most common of which was status epilepticus (n=9 [6%]).

185 eadache that progressed to hydrocephalus and status epilepticus necessitating a medically induced com

186 six had encephalitis with seizures (one with status epilepticus needing pharmacologically induced com

187 tives was described in patients with stroke, status epilepticus, neurodegenerative disorders, neurotr

188 Convulsive status epilepticus often results in permanent neurologic

189 EG) confirmed status epilepticus, refractory status epilepticus on day 1, "super-refractory" status e

190 The rate of progression to EEG-confirmed status epilepticus on the first day was lower in the hyp

191 Increased C-reactive protein levels at status epilepticus onset were associated with higher rat

192 rs; five male patients) developed refractory status epilepticus or epilepsia partialis continua along

193 icus, and a wean failure as either recurrent status epilepticus or the resumption of anaesthesia for

194 jections of kainic acid (20 mg/kg) to induce status epilepticus or the vehicle (saline).

195 rm of encephalitis with seizures, refractory status epilepticus, or both.

196 s the specific impact of therapeutic coma on status epilepticus outcome.

197 en daily calorie intake and outcome in adult status epilepticus patients deriving from a 5-year cohor

198 population-standardized hospitalizations for status epilepticus per 100 000 persons increased by 56.4

199 ths to younger than 18 years with convulsive status epilepticus presenting to 1 of 11 US academic ped

200 Excessive activation of TrkB caused by status epilepticus promotes development of temporal lobe

201 logistic regression analysis disclosed that status epilepticus, psychosis and cognitive dysfunction

202 For this purpose, we used two distinct post-status epilepticus rat models, in which epilepsy was ind

203 agents for refractory generalised convulsive status epilepticus, rather than additional trials of sec

204 was reduced to 63% of controls 5 days after status epilepticus, recovered to 93% of controls in vehi

205 Pharmacologic P2Y(1) blockade during status epilepticus reduces also associated brain damage,

206 electroencephalographically (EEG) confirmed status epilepticus, refractory status epilepticus on day

207 al cross-sectional studies including 408 304 status epilepticus-related hospital visits using general

208 ere used to estimate population-standardized status epilepticus-related hospitalization rates using I

209 , yet limited data exist detailing trends in status epilepticus-related hospitalizations and mortalit

210 Status epilepticus-related hospitalizations were categor

211 connect exists between the relatively stable status epilepticus-related mortality and the marked incr

212 Age-standardized status epilepticus-related mortality per 1 000 000 perso

213 y, its frequency in patients with convulsive status epilepticus remains unknown.

214 Uncontrolled episodes of status epilepticus require intensive care treatment and

215 6 months to under 18 years, with convulsive status epilepticus requiring second-line treatment, were

216 tus epilepticus on day 1, "super-refractory" status epilepticus (resistant to general anesthesia), an

217 n, adults, and older adults with established status epilepticus respond similarly to levetiracetam, f

218 rarchy in approach in controlling refractory status epilepticus (RSE) and super-refractory status epi

219 isolating brain capillaries from rats after status epilepticus (SE) and in chronic epileptic (CE) ra

220 the onset of severe acute seizures known as status epilepticus (SE) are crucial for the process of e

221 Status epilepticus (SE) can cause brain damage and lead

222 ally relevant question is whether early post-status epilepticus (SE) evoked chloride dysregulation is

223 neuron precursors into the hippocampus after status epilepticus (SE) greatly restrained SRS and allev

224 cial for restraining seizures, cannot thwart status epilepticus (SE) induced neurodegeneration or dow

225 Status epilepticus (SE) is a common neurological emergen

226 Status epilepticus (SE) is a life-threatening condition

227 Status epilepticus (SE) is a life-threatening disease th

228 Status epilepticus (SE) is a prevalent disorder associat

229 Human status epilepticus (SE) is associated with a pathologica

230 Male rats underwent pilocarpine-induced status epilepticus (SE) or sham treatment at P56.

231 , we used a rat model of pilocarpine-induced status epilepticus (SE) to investigate HIF-1alpha expres

232 The generalized seizures of status epilepticus (SE) trigger a series of molecular an

233 Status epilepticus (SE) triggers pathological changes to

234 ss plays in determining KCC2 activity during status epilepticus (SE) using knockin mice in which S940

235 As epileptogenic insult, a status epilepticus (SE) was induced in rats by lithium p

236 Status epilepticus (SE), a medical emergency that is typ

237 roduced in 50% of rats reduced threshold for status epilepticus (SE), accelerated epileptogenesis, an

238 Transient brain insults, including status epilepticus (SE), can trigger a period of epilept

239 insults, such as trauma, stroke, anoxia, and status epilepticus (SE), cause multiple changes in synap

240 mensional inflammatory response ensues after status epilepticus (SE), driven partly by cyclooxygenase

241 found that in the mouse pilocarpine model of status epilepticus (SE), systemic administration of TG6-

242 to adult-born DGCs after pilocarpine-induced status epilepticus (SE), whereas normotopic DGCs synapse

243 n either before or after pilocarpine-induced status epilepticus (SE).

244 s, including trauma, stroke, infections, and status epilepticus (SE).

245 ifferent brain insults, such as ischemia and status epilepticus (SE).

246 blood-brain barrier P-gp up-regulation after status epilepticus (SE).

247 is an episode of de novo prolonged seizures [status epilepticus (SE)].

248 r treatment of a child with super-refractory status epilepticus secondary to FIRES.

249 nterquartile range, 42-76], 55% male, median Status Epilepticus Severity Score 3 [interquartile range

250 iscrimination and calibration indicated that Status Epilepticus Severity Score performed reasonably w

251 Only Status Epilepticus Severity Score was associated with in

252 nd status epilepticus classification per the Status Epilepticus Severity Score were recorded.

253 t demographics, status epilepticus etiology, Status Epilepticus Severity Score, and status epilepticu

254 of anesthetic drugs, mechanical ventilation, Status Epilepticus Severity Score, refractoriness of sei

255 ance: Prolonged seizures in super-refractory status epilepticus (SRSE) have been shown to cause neuro

256 Super-refractory status epilepticus (SRSE) is a life-threatening form of

257 ome measures of occurrence of first seizure, status epilepticus, stroke-like episode, and death.

258 parameters resulted in immediate relapse of status epilepticus, suggesting a pivotal role of deep br

259 orth London, UK (the north London convulsive status epilepticus surveillance study cohort; NLSTEPSS).

260 ined as frequency of complications following status epilepticus termination and return to premorbid f

261 Complications after status epilepticus termination are frequent and associat

262 ative risks of complications occurring after status epilepticus termination for no return to premorbi

263 on the ICU for more than 24 hours following status epilepticus termination.

264 epticus (SRSE) is a life-threatening form of status epilepticus that continues or recurs despite 24 h

265 ar-old boy with a prolonged super-refractory status epilepticus that eventually resolved after commen

266 The choice of drugs for patients with status epilepticus that is refractory to treatment with

267 ate - in children and adults with convulsive status epilepticus that was unresponsive to treatment wi

268 text of benzodiazepine-refractory convulsive status epilepticus, the anticonvulsant drugs levetiracet

269 e showed that, following pilocarpine-induced status epilepticus, there are two independent changes in

270 during successful anaesthetic liberation in status epilepticus; these findings are absent in patient

271 d in guidelines for management of refractory status epilepticus; this is, however, based on weak evid

272 agents are typically titrated in refractory status epilepticus to achieve either seizure suppression

273 Consecutive patients with status epilepticus treated at the ICUs from 2012 to 2016

274 We examined nationwide variability in status epilepticus treatment by analyzing 33 publicly av

275 In the Established Status Epilepticus Treatment Trial (ESETT) we compared t

276 nical trials, such as the ESETT (Established Status Epilepticus Treatment Trial), compare effectivene

277 Among pediatric patients with convulsive status epilepticus, treatment with lorazepam did not res

278 As the episode of status epilepticus waned, smaller volume of brain was ac

279 rom randomisation to cessation of convulsive status epilepticus was 35 min (IQR 20 to not assessable)

280 Refractory status epilepticus was a secondary outcome.

281 Electrically induced status epilepticus was characterized by electroencephalo

282 Status epilepticus was convulsive in 124 (70.1%) and non

283 Status epilepticus was initiated by electrical stimulati

284 Convulsive status epilepticus was terminated in 106 (70%) children

285 hospitalizations were categorized by whether status epilepticus was the principal diagnosis, whether

286 In 2010, status epilepticus was the reported underlying cause of

287 l of acquired epilepsy induced by electrical status epilepticus, we show that oxidative stress occurs

288 ial instability emerged around 6 weeks after status epilepticus, well after the onset of chronic seiz

289 Poor outcomes in new-onset status epilepticus were associated with older age as wel

290 Patients with status epilepticus were identified by retrospective sear

291 All patients with status epilepticus were monitored regarding nutrition su

292 e found that 48% of children presenting with status epilepticus were unresponsive to benzodiazepine t

293 They develop epilepsy after experiencing status epilepticus when naturally exposed to domoic acid

294 ay be a treatment option in super-refractory status epilepticus when other treatment options have fai

295 270 critically ill patients with convulsive status epilepticus who were receiving mechanical ventila

296 ients with 11 episodes of serial seizures or status epilepticus, who underwent MRI and (18)F-FET PET,

297 on and diagnostic evaluation of the child in status epilepticus will help identify causes, which may

298 er proband subsequently developed refractory status epilepticus, with dramatic electroclinical improv

299 echanism underlying benzodiazepine-resistant status epilepticus, with relevance to how this life-thre

300 e (FIRES), a subtype of new onset refractory status epilepticus, with the recombinant interleukin-1 (