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1 ucture of the phylogenetically conserved ISS stem loop.
2 e more frequent in the absence of a relevant stem-loop.
3 RNA can be replaced by this U6atac distal 3' stem-loop.
4 ally distinctive, lacking the essential P6.1 stem-loop.
5 pecific requirements for the frameshift site stem-loop.
6 thylene blue-labeled structure-switching DNA stem-loop.
7 the HIV-1 trans-activation response element stem-loop.
8 otection of the nucleotides that form the 5' stem-loop.
9 h disrupts a Watson-Crick base pair in the T-stem-loop.
10 re not polyadenylated but end in a conserved stem-loop.
11 and carrier sequences stabilized by a miR-30 stem-loop.
12 llustrates the recognition of unbranched RNA stem loops.
13 transcripts containing 5' MS2 and 3' PP7 RNA stem loops.
14 ve structures comprising either four or five stem-loops.
15 30% preferred structured motifs folding into stem-loops.
16 acting RNA element characterized by multiple stem-loops.
17 e of APOBEC3A, a cytidine deaminase, for DNA stem-loops.
18 esults demonstrate that binding sites within stem-loop 1 of the 5' untranslated region play important
19 g; of the sites tested, those located within stem-loop 1 of the 5' UTR had the most significant effec
20 A, we found that extending the tetraloop and stem loop 2 of the sgRNA with MS2 or PP7 aptamers enhanc
21 y RNA target of FUS via its interaction with stem-loop 3 and provide atomic details of this RNA-media
23 RM binds the 3' end of 7SK RNA at the top of stem-loop 4 (SL4) and interacts with both unpaired and b
24 vivo, due to their preventing formation of a stem-loop 5' of the take-off codon and allowing greater
25 Here we investigate the function of the mRNA stem-loop 5' of the take-off codon, as well as the impor
31 ing the entire assembly, but the U4 snRNA 5' stem-loop adopts alternative orientations each stabilize
33 he impact of several key components of miRNA stem loops and their flanking sequences on the efficienc
36 tem-loop binding protein (SLBP) binds to the stem-loop and is required for all steps in histone mRNA
37 mic structural rearrangements between tandem stem-loop and mRNA pseudoknot structures in two of the s
38 from the 5'-UTR, including the terminator 5'-stem-loop and Shine-Dalgarno blocking hairpins, demonstr
39 e-stranded region of U4 snRNA between its 3' stem-loop and the U4/U6 snRNA stem I is loaded into the
40 One product mapped to a predicted 5'-SL (stem-loop) and two others mapped just 5' to Shine-Dalgar
42 viral genome, built atomic models for 16 RNA stem-loops, and identified three conserved motifs of RNA
44 recurrent APOBEC-signature mutations not in stem-loops are enriched in well-characterized driver gen
45 h the sequences and the structure of the two stem-loops are important for CRD-BP-GLI1 RNA binding.
53 siRNA sequences into a Dicer-independent RNA stem-loop based on pre-miR-451 microRNA-which is highly
57 eduction was correlated with lower levels of stem-loop binding protein (SLBP), which is known to cont
59 eveals that eIF3 uses different modes of RNA stem-loop binding to exert either translational activati
61 and Cy5 on dsRNA, using complexes of an RNA stem-loop bound to L5 protein determined at 2.4 A resolu
62 lly sequestered in a branchpoint-interacting stem-loop (BSL)(8), but whether the human U2 snRNA folds
63 f the structure and dynamics of the UUCG RNA stem-loop by combining molecular dynamics simulations wi
67 nslated region (UTR) of NT8 contains a short stem-loop cis-element that is necessary for the regulati
68 biomineralisation proteins Mms13 and MmsF on stem-loop coiled-coil scaffold proteins (Mms13cc/MmsFcc)
69 aged single beta-actin mRNAs tagged with MS2 stem loops colocalizing with labeled ribosomes to determ
70 nigenomic RNA indicates formation of a small stem-loop composed of the HSPA8 motif, a 3' stem-loop (n
71 V-1 primer binding site, (-)PBS, both in its stem loop conformation and in the corresponding (-)/(+)P
72 re, involving the recognition of ssRNA via a stem-loop conformation, together with our two previous s
74 ination, we targeted LRV1 using long-hairpin/stem-loop constructs similar to those effective against
77 itative analysis showed that the stimulatory stem loop destabilizes the hybrid state and elevates the
81 system is based on a conformation-switching stem-loop DNA scaffold that presents a small-molecule, p
83 structure utilizes an electrode-immobilized stem-loop (DNA-hairpin) probe and two DNA adaptor strand
85 report that the HalV 5' UTR comprises small stem-loop domains separated by long single-stranded area
86 irected at architectural motifs in BC RNA 5' stem-loop domains that serve as dendritic targeting elem
88 cific RNA-protein complexes, such as histone stem-loop elements and their nucleotides that hydrogen b
91 transcripts (pri-miRNAs), with the choice of stem loops for initial processing largely determining wh
92 se data highlight the significance of the 5' stem-loop for the 50-nt bypassing and further enhance ap
93 ication assays, we demonstrate that the five stem-loop form of the RRE promotes greater functional Re
94 hown to mediate efficient nascent transcript stem loop formation-dependent RNA-DNA hybrid realignment
95 n Qrr4 vital for stability, Hfq interaction, stem-loop formation, and base pairing to both luxR and l
97 5' untranslated region contains a predicted stem-loop-forming structure adjacent to the +59 motif.
98 ependent RNA polymerase, confirming that the stem-loop forms the core of the norovirus subgenomic pro
99 newal, DDX6 associates with YBX1 to bind the stem loops found in the 3' UTRs of regulators of prolife
100 f the HIV type 1 (HIV-1) RNA frameshift site stem-loop, frameshift efficiency, and infectivity, using
101 eriments, we studied how frameshift-inducing stem-loops from E. coli dnaX mRNA and the gag-pol transc
102 in multiple kinetoplastid species, putative stem-loops from L. donovani and Trypanosoma brucei nucle
103 epeat (full-DR-crRNA) sequence with specific stem-loop G-C base substitutions exhibit increased editi
104 c stability, high repetitiveness, and stable stem-loop/hairpin secondary structures that are hallmark
105 knot structure with coaxial alignment of the stem-loop helix (P1) and the pseudoknot helix (PK).
107 inding (Kd = 120 +/- 10 nm) to the conserved stem-loop I of the 3'-BTE by exposing more unpaired base
108 aled that the 5'U-Ubulge and central loop of stem-loop I or RNA motif 3 of 7SK are required for trans
112 thylation of two conserved adenosines in the stem loop II region of HIV-1 Rev response element (RRE)
114 We also present evidence that vsRNA1 targets stem-loop II of the viral 5' untranslated region and inh
116 s a result of greater Shannon entropy in RRE stem-loop II, which is key to primary Rev binding.IMPORT
119 s followed by formation of a strong, GC-rich stem-loop in the RNA exit channel of RNA polymerase (RNA
121 the trans-acting factor that binds the LdNT3 stem-loop in vivo is substantially higher than required
122 t cyclin F co-evolved with the appearance of stem-loops in vertebrate H2AFX mRNA to mediate SLBP degr
124 ix 8 alterations including single and double stem-loop insertions as well as loop diminutions affecti
125 Reporter assays confirmed that cap-distal stem-loop insertions increase dependence on Ded1 but not
132 op interaction between the 3'BTE and a 5'UTR stem-loop is necessary for translation to initiate.
135 teraction of PCBP2 with the apical region of stem-loop IV (SLIVm) of poliovirus RNA in its full-lengt
137 r with one another (similar to characterized stem-loop kissing interactions) forming a hitherto undes
138 use of sgRNAs truncated for the 3'-terminal stem loops leads to reduced activity during genomic edit
139 re analyses from NGS indicated extensive TAR stem-loop malformations predicted to inactivate proviral
140 r, poly-A-containing arms flanking the miRNA stem-loop markedly enhanced transgenic miRNA expression.
141 he temperature-dependent TSS selection and a stem-loop masking of ribosome binding sites was predicte
143 tes yeast and mammalian ribosomes and an RNA stem-loop mimic of the sarcin/ricin loop (SRL) at a high
145 l predicted sites within the 'stem' when the stem-loop model was first proposed and no mutations have
146 onstrate the potential importance of the two-stem-loop motif as a target region for the inhibition of
151 y junction (FWJ) and its appropriate control stem-loop motifs (Dumbbell, GAAATT-Hp, CTATC-Hp, GTGC-Hp
152 en-J) junction and their appropriate control stem-loop motifs (GAAATT-Hp, CTATC-Hp, and Dumbbell).
153 d-J and Open-J with those of their component stem-loop motifs allowed us to be more specific about th
155 We found a c.915+15A>C exon 10/intron 10 stem loop mutation in all affected subjects but not in t
157 stem-loop composed of the HSPA8 motif, a 3' stem-loop (nucleotides 1868-1890) that is similar to a p
158 rmined that the xRRM of LARP7 binds to the 3 stem loop of 7SK and inhibits the methyltransferase acti
160 demonstrate that p65 protein-binding apical stem-loop of U12 snRNA can be replaced by this U6atac di
162 o obtain l-RNA aptamers that bind the distal stem-loop of various precursor microRNAs (pre-miRs).
163 the effect of the +59 motif and the adjacent stem-loop on cagA transcript levels and cagA mRNA stabil
164 can act by pairing with ribosomal RNA or as stem loops or pseudoknots even with one component being
165 sin-V dimer "walking" on an actin fibre, RNA stem-loop packing, and the simulation of cell motion and
166 Moreover, experimental investigation through stem-loop PCR of a random collection of newly discovered
167 ds out among these miRNAs because its entire stem-loop precursor overlaps the coding sequence for the
168 de RNAs, some of which are predicted to have stem-loop precursors potentially representing miRNAs.
169 nse oligonucleotide, containing two distinct stem-loops present in nts 320-380 of GLI1 RNA, was found
173 NA adaptor strands complementary to both the stem-loop probe and the targeted fragment of a ZIKV ampl
174 To increase target miRNA specificity, a stem-loop probe was introduced instead of a linear probe
175 oelectrodes in the fabrication of linear and stem-loop probe-based electrochemical DNA (E-DNA) sensor
178 rophores or affinity labels into a short RNA stem loop recognition motif by exchange of a guanine res
181 u1 specifically interacted with the variable-stem-loop region in the 3' NTR and domain IIId of the HC
182 Our previous work demonstrated that the 3' stem-loop region of U6atac snRNA contains a U12-dependen
183 miRNAs, including the sequences flanking the stem-loop region, contributed to high affinity EWS bindi
184 As) are small regulatory RNAs processed from stem-loop regions of primary transcripts (pri-miRNAs), w
185 als a decrease in secondary structure within stem-loop regions of these transcripts in mta mutant pla
186 Mutant MNV RNAs with substitutions in the stem-loop replicated poorly until they accumulated mutat
188 esp. HCV] contribute to the formation of the stem-loop [resp. double stem-loop] secondary structure k
189 RNA and mRNA profiling using high throughput stem-loop reverse-transcriptase quantitative polymerase
190 ts with severe asthma using high-throughput, stem-loop, reverse transcriptase quantitative real-time
192 g messenger RNAs (mRNAs) via a high-affinity stem-loop RNA binding domain interaction, enabling high-
197 ements), and form a thermodynamically stable stem-loop secondary structure (structure requirement).
198 lippery sequence and an immediate downstream stem-loop secondary structure, together called frameshif
200 the formation of the stem-loop [resp. double stem-loop] secondary structure known as the frameshift s
203 , in vitro biochemical data suggest that the stem-loop sequence is sufficient for the initiation of v
204 n via an RNA-binding protein that recognizes stem-loop sequences engineered into the viral genome.
205 sMIR390-based precursors that include distal stem-loop sequences from Arabidopsis thaliana MIR390a (A
206 ary structural elements, only a single 15-nt stem-loop showed a strong correlation with splicing, act
207 cture of QueG bound to a tRNA(Tyr) anticodon stem loop shows how this enzyme uses a HEAT-like domain
208 R/sfRNA of the wild-type virus mapped to RNA stem-loops SL-III and 3' SL, which stick out of the thre
209 ding the transcription factor Xbp1 at a dual stem-loop (SL) structure, leading to Xbp1 splicing and a
213 ind that upon encountering the ribosome, the stem-loops strongly inhibit A-site tRNA binding and ribo
214 ing the interaction of a West Nile virus RNA stem loop structure with the human T cell-restricted int
216 mented by binding of protein LARP6 to the 5' stem-loop structure (5'SL), which is found exclusively i
217 terminal capsid coding region, including the stem-loop structure (5'SL6) at the 3' end of the promote
219 These results indicate that both a predicted stem-loop structure and a strain-specific +59 motif in t
220 abels to monitor changes in the mini TAR DNA stem-loop structure brought on by the HIV-1 nucleocapsid
223 s sequence, translation activity relies on a stem-loop structure identified at nucleotide positions 4
224 versatile protein that can interact with the stem-loop structure in RNA and with G quadruplex DNA.
225 tically, MCPIP1 physically interacted with a stem-loop structure in the 3' untranslated region of the
228 e local stability of the frameshift site RNA stem-loop structure increase frameshift efficiency 2-fol
231 ect binding between endogenous TruB1 and the stem-loop structure of pri-let-7, which also binds Lin28
232 presence of an evolutionarily conserved RNA stem-loop structure on the negative-sense RNA, the compl
233 mutagenesis, we found that disruption of the stem-loop structure reduced steady-state mRNA levels bet
234 ound that mutations predicted to disrupt the stem-loop structure resulted in decreased steady-state l
235 enesis of the +59 motif without altering the stem-loop structure resulted in reduced steady-state cag
236 ere we describe the identification of an RNA stem-loop structure that functions as the core of the no
238 for ZCCHC4-RNA recognition and a role of the stem-loop structure within substrate in governing the su
241 existence of a preferred binding site in the stem-loop structure, in which ametantrone intercalates i
242 e linked to cycles of folding/unfolding of a stem-loop structure, or to interconversion between highe
250 osome is an efficient helicase, certain mRNA stem-loop structures are known to impede ribosome moveme
251 s within these transcripts predicted to form stem-loop structures are processed by Microprocessor and
252 -derived sequences with predicted stem-bulge-stem-loop structures are sufficient to mediate mRNA tran
253 The switch mechanism relies on two putative stem-loop structures contained within the 5' untranslate
254 se results suggest that disruption of exonic stem-loop structures immediately upstream (but not downs
256 nking short base-paired DNA stretches, as in stem-loop structures of single-stranded DNA (ssDNA) deri
257 toxin hamper its translation by stabilizing stem-loop structures that sequester the Shine-Dalgarno s
260 emities of small RNA footprints or predicted stem-loop structures, in agreement with the model of pas
261 in plants rely extensively on the search for stem-loop structures, leading to high false negative rat
262 hown to cleave within 3'-untranslated region stem-loop structures, which contain double-stranded RNA,
268 binding surface to recognize the base of its stem-loop target RNA and extends a newly-formed alpha he
274 ingle sgRNA, modified to contain MS2-derived stem loops that recruit fusion proteins consisting of th
275 equired the proper spatial organization of a stem-loop that is mainly determined by the U-rich elemen
276 ta suggest that 3D interacts in cis with RNA stem-loops that are essential for viral RNA replication.
277 of dispersed assembly signals in the form of stem-loops that each present a minimal CP-binding motif
278 in modular domains consisting of one or more stem-loops that harbor conserved RNA motifs critical for
280 -binding motif, the relative placement of PS stem-loops, their number, and their folding propensity.
281 y of the RNA structure, the proximity of the stem loop to the slippage site, the length and compositi
283 and for the detailed structural change from stem-loop to duplex RNA-DNA when complementary RNA was p
284 ement), that regulated levels of all pri-miR stem loop transcription and resulting microRNA expressio
287 structure of the substrate stem loop I (SLI)-stem loop V (SLV) kissing loop junction of the Varkud Sa
288 covery of a "hit" molecule able to bind this stem-loop, we now report the development of compounds di
290 y that completely unfolds the tRNA anticodon stem-loop, which is likely critical for recognition of b
291 ice leader downstream of the let-7 precursor stem-loop, which produces a short polyadenylated downstr
292 uses an oligodeoxynucleotide that folds to a stem-loop with a TG-rich double-stranded region and a 3'
294 condary structures of these regions revealed stem-loops with conservation of structure and a common m
296 ied clustered hyperediting within long dsRNA stem loops within 3' untranslated regions of endogenous
298 lear magnetic resonance (NMR) structure of a stem-loop within the c-JUN 5' UTR recognized by eIF3 and
300 Homeobox (Hox) 5' UTR, we identify a modular stem-loop within this element that binds to a single ES,