ライフサイエンスコーパス: step

1 n of lamellae formed during the first growth step.

2 cal properties of the QDs at each patterning step.

3 publication-ready results and figures in one step.

4 ruction of multiple ring systems in a single step.

5 omatic ring is involved in the rate-limiting step.

6 LC-MS/MS methods, each in a single enzymatic step.

7 hosphine dosage during the surface treatment step.

8 e of the kinetically much reduced nucleation step.

9 -component Ugi reaction (Ugi-4CR) as the key step.

10 h the Mn-I exchange and the C-C bond-forming steps.

11 n feature extraction and following filtering steps.

12 h been prepared from cyclopentanone in eight steps.

13 nge coupling of electron and proton transfer steps.

14 onformational changes with chemical reaction steps.

15 s, demonstrating that it uncouples these two steps.

16 nostic and validation tools for all relevant steps.

17 the need of a secondary antibody, or washing steps.

18 complex and lengthy processing and assembly steps.

19 of its stereoisomers was accomplished in 10 steps.

20 ue functional molecules in minimal synthetic steps.

21 t can also drive secondary energy-conversion steps.

22 fraction without the need for any additional steps.

23 intermolecular metal-mediated self-assembly steps.

24 urs to complete involving many sophisticated steps.

25 does not require sample treatment or washing steps.

26 numerical modeling of myosin V diffusion and stepping.

27 he STN is involved in the dynamic control of stepping.

28 ith different numbers of minimization and MD steps, 10 different force fields and three different wat

29 review, we will highlight the ways in which STEP(61) differentially regulates NMDARs and AMPARs, as

30 al synthesis of (+)-6-epi-ophiobolin A in 14 steps, a task which addresses construction of the synthe

31 RT-qPCR assay that omits the RNA extraction step altogether.

32 step is before the first tension-generating step and is moderately fast.

33 ing total synthesis of the alkaloid in three steps and a 36% overall yield.

34 t decouple the cycloaddition from subsequent steps and allow interception and characterization of thi

35 ed to minimize the number of sample-transfer steps and facilitate the direct enzymatic digestion of e

36 However, the need for several reagents and steps and the high cost of PCR hinder its worldwide impl

37 ect of water molecules on prominent reaction steps and their associated energies.

38 te a rate-limiting C-H reductive elimination step, and calculations attribute this to a significant s

39 ssion genes were identified at the screening step, and finally found six mostly changed hub genes inc

40 olved in processing the detail of individual steps, and DMN adding representation of broad task conte

41 including inchworm-like movements, backward steps, and foot stomps.

42 nded PET, compared with DDG for conventional step-and-shoot scans.

43 th rich edge sites are synthesized via a one-step approach by harnessing geometric constraints.

44 It performs imputation using a two-step approach.

45 number of steps per day and the intensity of stepping are associated with lower mortality.

46 e a protocol optimization is identified, the steps are as follows: identification of the imaging situ

47 f the changes in free energy of intermediate steps are minimized and the catalytic cycle is devoid of

48 regions in a POOR-get-POORer fashion unless steps are taken to interrupt it.

49 However, the multiple steps associated with proton-coupled electron transfer r

50 at predefined intervals and enables a single-step batch correction and quantification for high-throug

51 al identity of cell clusters is an important step before downstream analyses and it remains technical

52 G proteins has been emerging in incremental steps, but attributing biological significance to their

53 st data processing workflows include similar steps, but underlying algorithms and implementation of d

54 solved via a computational method called the step-by-step linearization method (SSLM).

55 leading to product evolution in a controlled step-by-step manner.

56 We provide a step-by-step overview, a tailored set of consensus crite

57 detail in our methods sections and to share step-by-step protocols in protocol repositories or journ

58 Quick start and step-by-step tutorials as well as tutorial data are full

59 ethane generation, compared to the competing step, C-C coupling.

60 The olefin metathesis step can be carried out with substrates and a Mo-based c

61 ation of proteins and lipids at intermediate steps can only be resolved with cryo-electron tomography

62 ardiac cycle and their dynamic response to a step change in MAP was calculated by means of transfer f

63 jects in three different protocols involving step changes in exercise load and compared the results t

64 Achieving step changes in genetic yield potential is crucial to en

65 -state measurements and dynamic responses to step changes in light intensity are assessed.

66 rs (e.g. Murrumbidgee, Macintyre) experience step changes towards greater discontinuity, characterise

67 This approach takes us one step closer to mass production of macroscopic monolayers

68 as a novel fibrotic-switch, bringing us one step closer to understanding the complex biological mech

69 ntally friendly and eliminates the acid etch steps common to conventional sapphire preparation, sugge

70 d for this novel synthesis is the facile one-step construction of a spiroketal trimer intermediate, w

71 e reveals that the cyclization step is a key step controlling the selectivity of the process.

72 Median daily step count was similar among men (7202 with interquartil

73 trains with the most conserved genes of each step deleted, but also additional modifications are dete

74 les simulations of all critical experimental steps, distinctive roaming signatures were identified.

75 of azole, either as initial treatment or as step-down therapy from amphotericin B.

76 A key step during HCMV reactivation in latently infected HPCs

77 sp(3) )-H bond cleavage is the rate-limiting step during the reaction process.

78 sera from patients without any amplification step (e.g., PCR) required, thus simplifying the operatio

79 An atom- and step-economic synthesis of aryliminophosphoranes bearing

80 ral coordination MgO lattice positions under step-edges, hence highly confined by the oxide support.

81 e masking effect in outliers, and a backward step eliminates swamping effects.

82 n couples substrate specificity to an ATPase step essential for DNA methylation.

83 he synthesis of alkenes using a one-pot, two-step experimental setup.

84 We employed a two-step fabrication process to ensure an even mixture and d

85 y the effect of aging time and manufacturing steps (filtration, addition of additives or spices, sole

86 ng molecular weight cutoff (MWCO) filtration step followed by shotgun proteomic analysis.

87 window, sample processing is a time-limiting step for research on the early life-history stages of co

88 rial neonatal meningitis and is an important step for the continued development of phage therapy targ

89 clopentadiene system, and a final protection step for the easy isolation and purification of the prod

90 ata show that HS17B3 acts as a rate-limiting-step for the maximum level of testosterone production by

91 igh quality genome assembly is a vital first step for the study of an organism.

92 Here, we reveal key steps for the pro-motion of this reaction by water when

93 ins for the meninges prior to proposing next steps for this work.

94 environmental cues represents a significant step forward in the development of synthetic materials t

95 Recoveries of the enrichment step from spiked bovine serum albumin digests were >80%

96 Mechanisms of regulation at each step, from initiation to elongation dynamics, produce qu

97 ifferentiation is best described as a single step gradualistic process with a large number of transit

98 Disconnections of varying step heights are displayed and shown to define both defo

99 As a first step, how do we systematically trace the provenance of k

100 ented the content and position of individual steps, however the DMN preferentially represented task i

101 ss aliphatic sulfonamides, applying a single-step hydrosulfamoylation using inexpensive olefins, tris

102 OCT scans improved by 1 step in 10 patients in the PPV group.

103 tructural gene annotation is often the first step in analysis.

104 ngly implicating TJ disruption as a critical step in antigen responsiveness.

105 ls across nesting sites worldwide, a crucial step in assessing the impact of climate change on imperi

106 n of a cell into two daughter cells-is a key step in cell growth and proliferation.

107 e present study establishes that another key step in central metabolism is poisoned by molecular oxyg

108 that drive aortic degeneration is a crucial step in developing an effective pharmacologic treatment

109 A key step in domestication of the grapevine was the transitio

110 ed neurulation in vertebrates, is a critical step in embryogenesis.

111 the capsid at low pH and facilitating a late step in entry involving uncoating and delivery of the RN

112 ecular recognition of carbohydrates is a key step in essential biological processes.

113 ed signaling pathways is the essential first step in evaluating their therapeutic potential.

114 Power analysis becomes an inevitable step in experimental design of current biomedical resear

115 ruption leads to fitness defects, a critical step in identifying candidate cancer targets.

116 ecarboxylation is not a completely essential step in its catalysis.

117 ligand perception is considered to be a key step in KAR/KL signaling.

118 A salient step in many studies is to identify editing sites that s

119 ZMPSTE24 performs a key proteolytic step in maturation of prelamin A, the farnesylated precu

120 lytic resection of DSB-adjacent DNA is a key step in meiotic DSB repair, but this process has remaine

121 The first committed step in menaquinone biosynthesis is catalyzed by MenD, a

122 We find that the rate-limiting step in mRNA cleavage frequently involves unmasking of t

123 e O-H bond in H(2) O is a critical, limiting step in plasmonic photosynthesis.

124 s of this study represent an important first step in repurposing class I PI3K inhibitors to modulate

125 ng to CTC homing to the endothelium, a first step in secondary tumor formation.

126 ear polyubiquitin chains is a key regulatory step in signal transduction that impacts cell death and

127 inally-differentiated myocytes is a critical step in skeletal muscle development and repair.

128 Our result offer insight into a key step in substrate ubiquitination by a member of the larg

129 iod about 400 Mya and represent a transition step in tetrapod evolution.

130 and antigenic peptides is the most selective step in the antigen presentation pathway.

131 igin and catalyzes the terminal chlorination step in the biosynthesis of (-)-acutumine.

132 orylase, which catalyzes the first committed step in the biosynthesis of Asc.

133 rase (PNMT, EC 2.1.1.28) catalyzes the final step in the biosynthesis of epinephrine and is a potenti

134 uentially identified the target item of each step in the correct order.

135 IMPDH1 catalyzes the rate-limiting step in the de novo synthesis of guanine nucleotides, im

136 imming, suggesting that this is an important step in the decay mechanism.

137 a closed protein shell (or capsid) is a key step in the replication of viruses and in the production

138 It was then successfully applied as the key step in the synthesis of the natural product lamellarin

139 om a limited cohort provide a critical first step in understanding the earliest immune response to HI

140 lls and endothelial cells (ECs) is a crucial step in vascular inflammation.

141 00 operations while reusing only 22 distinct steps in 10 unique modules, with the code able to access

142 cloning in wheat is to manually perform many steps in a long bioinformatics pipeline.

143 ing a cascade of fast and co-occurring redox steps in enzymatic systems such as ferritin.

144 , assembly, and release, implying additional steps in IB function.

145 Arfs control distinct steps in intracellular membrane traffic, and one of the

146 d translation factors) and regulates crucial steps in protein synthesis.

147 One of the key steps in the assay is converting unmethylated cytosines

148 d formation and RNA replication, housing key steps in the virus life cycle that warrant further inves

149 urnover-limiting and selectivity-determining step induced by the optimal ligand.

150 of soy protein-based foods requires multiple-step, intensive processing and storage of soy ingredient

151 site-specific methods that require multiple steps, introduction of mutations, or use of enzymes.

152 The sequence of reaction steps involved in the C(5+) ketone formation from ethano

153 Here, we discuss the steps involved in tissue preparation for three-dimension

154 energy surface reveals that the cyclization step is a key step controlling the selectivity of the pr

155 conclude that, as in model A, the Pi release step is before the first tension-generating step and is

156 The lipid extraction step is time consuming and often employs toxic solvents

157 The basic rhythmic activity that underlies stepping is generated by a neural network, situated in t

158 vention participants, 491 (97%) received the Step it Up intervention.

159 The STEP-KOA strategy may be efficient for delivering exerci

160 All the steps leading to the final grafted molecular complex hav

161 teral mechanical perturbations affecting the step length over multiple gait cycles.

162 le the MD network preferentially represented step-level information.

163 y modest subcortical filtering, with robust, step-like attenuation in distractor processing between m

164 The sensor showed a two-step linear response from 0.05 to 5 muM and 5-30 muM wit

165 ia a computational method called the step-by-step linearization method (SSLM).

166 s "King of Bitters"), was accomplished in 14 steps (LLS).

167 to product evolution in a controlled step-by-step manner.

168 This finding suggests a multi-step mechanism of kinase activation.

169 nergy requirements, the number of procedural steps, miniaturization, and automation are just a few of

170 ic pattern when Parkinson's patients perform stepping movements, raising the question whether the STN

171 Second, we used two-step MR to investigate whether DNA methylation mediates

172 of machine-learning models, but appropriate steps must be taken to avoid overfitting.

173 earch efforts in order to elucidate the next steps needed to develop a fundamental framework needed f

174 rs proceeds in two steps, with a slow second step occurring over many days where native lipid membran

175 exception was comprehension of the composite step of "Check, give, and call 911 immediately" (thresho

176 yme-adenylate intermediate is a common first step of all DNA ligases.

177 A key step of an automated computational design algorithm is m

178 lium assembly pathway, controlling the final step of cilia initiation.

179 mRNA translation represents the last step of genetic flow and primarily defines the proteome.

180 hydratase (ALAD), which catalyzes the second step of heme biosynthesis, is an Fe-S protein.

181 A hallmark of the initiation step of HIV-1 reverse transcription, in which viral RNA

182 cognitive mechanisms work in concert at each step of its process: recognizing the problem, generating

183 at the cause of resistance lies in the entry step of MNV infection.

184 o termed deadenylation, is the rate-limiting step of mRNA degradation in eukaryotic cells.

185 ite adenosine, the nucleophile for the first step of splicing(1).

186 originally identified to catalyse the final step of the methanogenesis pathway.

187 ing the respiratory chain and each enzymatic step of the tricarboxylic acid (TCA) cycle.

188 eceptor recognition and binding is the first step of viral infection and a key determinant of host sp

189 um stimulator output (MSO) and increasing in steps of 2% until a motor response with a 50 uV peak to

190 fied to be deficient in post-transcriptional steps of chloroplast gene expression.

191 importance for hemostasis, the rate-limiting steps of CLEC-2-induced platelet activation are not clea

192 In the initiating steps of conjugative transfer, DNA transfer and replicat

193 ould target 30 genes that are implied in all steps of CRC tumorigenesis.

194 (bran, middlings, aleurone and I, II and III steps of debranning) and flour/semolina, using UHPLC-MS/

195 s and cons of each approach, (2) the general steps of each approach, and (3) the interpretation of th

196 e de novo DNA methylation that governs early steps of ESC differentiation.

197 and provides key insight into rate-limiting steps of G-quadruplex conformational dynamics.

198 has been shown to be necessary in the early steps of ICL repair to prevent aberrant nuclease resecti

199 and define the biochemical staging of these steps of infection.

200 only binders to the target protein, in early steps of lead compound development, and this process mak

201 Given that rate-limiting steps of metastasis are known to occur while tumor cells

202 cells had an unexpected advantage at initial steps of metastatic seeding, suggesting that Rab27a may

203 utic target for its involvement in the first steps of neurodegeneration as well as in cancer onset an

204 se separation (LLPS) facilitates the initial steps of ribosome biogenesis and other functions.

205 genes encoding enzymes responsible for most steps of the ABA biosynthesis pathway have been identifi

206 al networks to solve problems in the initial steps of the common pipeline for data analysis in metabo

207 mputed efficiently and assessed at different steps of the investigation.

208 potent derivatives, 22 and 30, inhibit early steps of the replicative cycles of HIV-1 and EV-A71 by i

209 nd Fe(2+) as well as the different oxidative steps of the various ferroxidase centers already known i

210 btain insights on the impact of each brewing step on the final product, being also very useful for ce

211 A three-step, one-pot reaction protocol was developed, and a ser

212 nation patterns and skeletal diversity in 10 steps or less from ent-steviol.

213 rations in their heart rate, number of daily steps or time asleep.

214 We provide a step-by-step overview, a tailored set of consensus criteria for

215 Alternate stepping pathways also exist, including inchworm-like mo

216 It is unclear whether the number of steps per day and the intensity of stepping are associat

217 ns and directed edges represent evolutionary steps, presenting evidence that the structural (i.e., ne

218 s are productive and implies a rate-limiting step, probably associated with recruitment of general tr

219 fficiently prepared using an alternative two-step procedure and controlled hydrogenation conditions.

220 activation at overgrowing tissue is a multi-step process requiring ROS- and JNK-mediated Mmp2 upregu

221 his suggests that protamine is using a multi-step process to loop the DNA rather than a one-step proc

222 arbon bond between these substances in a two-step process.

223 ep process to loop the DNA rather than a one-step process.

224 g-5.78Zn-0.44Zr subjected to a complex multi-step processing.

225 in our methods sections and to share step-by-step protocols in protocol repositories or journals.

226 Due to the complex multiple-steps protocols in data acquisition, extreme deviation o

227 e, participants in the highest versus lowest steps quartile lost 2.9% (95%CI, 1.8-4.1) more of their

228 ite release rate of KIF1A was similar to the stepping rate, indicating that during stepping, rear-hea

229 the UO(2)(s) surface as the rate-determining step rather than electron transfer or ion diffusion.

230 ents demonstrate that the Cope rearrangement step, rather than iminium formation, is rate-limiting.

231 to the stepping rate, indicating that during stepping, rear-head detachment is an order of magnitude

232 Many of these reduction steps require the presence of a catalyst to activate the

233 onformational switch and the phosphorylation step, resulting in the rapid generation of the more acti

234 ~ 5.7 nm) were synthesized via a one-pot two-step reverse microemulsion method.

235 here were dose-response associations between steps, SB (inverse) and MVPA quartiles, respectively, wi

236 orders of magnitude less than the equivalent step-scan experiment.

237 h-resolution location data and an integrated step-selection analysis to evaluate caribou, moose, bear

238 Instead of single/multiple-step single-type reactions commonly applied for on-surfa

239 ramps of various durations, amplitudes, and step sizes.

240 Specifically, the two-step solid-solid transition is governed by a competition

241 echanism of 2D halide perovskites during one-step spin-coating.

242 the primary outcomes of fast-pace 5- and 10-step stair ascent power.

243 ained structures are accessed in two to four steps starting from the (mostly) commercially available

244 st that the proposed method can be used as a stepping stone towards the development of an accessible

245 ntial and structural features and used a two-step strategy to select the relevant features.

246 d near-IR) highlighting a series of critical steps, such as preprocessing, data selection, feature ex

247 consists of a one-pot straightforward three-step synthetic route, including (i) CuBr(2)-mediated alp

248 electrodes often involves multiple laborious steps that are not directly scalable to current manufact

249 -based approach that allows us to follow the steps that couple ATP turnover to mechanical work.

250 ELISA is the involvement of multiple washing steps that desorbs the capture antigen/antibody off the

251 thermodynamic energies of reactions for each step, the intermolecular interactions between the substr

252 ticipants increased their preferred value of step time asymmetry to coincide with the lowest energy c

253 Kinematic gait measures (trunk displacement, step timing, gait velocity), EMG responses, and subjecti

254 rial samples upon a simple syringe injection step to initiate AST against all antibiotics.

255 E2 or E3 enzyme and then transferred in one step to the substrate.

256 ing the structures of proteins is a critical step to understand their biological functions.

257 oach uses two independent adaptive evolution steps to address the lack of experimental methods to sys

258 cal workflow is the enactment of a series of steps to perform a clinical activity.

259 se, pharmacological interactions, and future steps to provide clearer guidance regarding its cardiova

260 for PRSs and GWAS were used along with extra steps to rule out confounding due to ancestry.

261 lycosylation features and is a crucial first step toward a better understanding of the mechanisms reg

262 yotic phototrophs and represent an important step toward a comprehensive assessment of greenhouse gas

263 o genomic surveillance systems, an essential step toward a more comprehensive understanding of resist

264 termine individual particle acidity and is a step toward addressing a key measurement gap related to

265 This preliminary study is a first step toward automated PET/CT assessment for lymphoma.(C)

266 characterization of exosomes is an important step toward clinical applications that require effective

267 tive mechanisms would represent an important step toward combating this disease.

268 al model as input, representing an important step toward comprehensive modeling of the MHC class I pa

269 The proposed framework is a first step toward developing asthma remission as a treatment t

270 The ACA approach takes a step toward maximizing the capabilities of existing real

271 actors for incarceration provides an initial step toward mitigating the excess morbidity and mortalit

272 s with arbitrarily small separation and is a step toward realizing strongly interacting atomic defect

273 tively, these advancements represent a major step toward realizing the enormous potential of surrogat

274 e on ACL regeneration and signal a promising step toward the clinical translation of a functional bio

275 with different Pt sizes and represents a key step toward the rational design of new heterogeneous cat

276 l-world problem, thus providing an important step toward understanding human sequential decision maki

277 ivity response from past events are critical steps toward improving predictions of future marine heat

278 These findings are a step towards developing a panel of genetic markers asses

279 Our work marks an important step towards enabling application-specific analog comput

280 The work also constitutes an important step towards large-scale quantum dot simulators of corre

281 isation of glucose to fructose is a critical step towards manufacturing petroleum-free chemicals from

282 ial atoms into phase-stable PICs marks a key step towards multiplexed quantum repeaters(7,8) and gene

283 t of diseases as a necessary and fundamental step towards precision medicine, which will benefit men'

284 t the first and second positions, an initial step towards producing completely unnatural polypeptides

285 3D-SMART represents a critical step towards the untethering of single molecule spectros

286 /Munc18-1 complexes in multiple intermediate steps towards the SNARE complex.

287 Quick start and step-by-step tutorials as well as tutorial data are fully incorp

288 s and implementation of different processing steps vary.

289 We present a single-step, versatile strategy for the selective modification

290 -A(2)B(2) porphyrins were synthesized in two steps, via [2+2] condensation between thioglycosylated d

291 s a clear path to the next generation of two-step VT complexes through incorporation of mixed-valence

292 The key step was an intramolecular [2 + 2]-photocyclization.

293 dition), the pull-force required to induce a step was less than when the visual field either rotated

294 In a second step, we selected the best performing model that provide

295 ed in combination with a sample pretreatment step, when detecting melamine from milk.

296 During human walking, step width is predicted by mediolateral motion of the pe

297 eral moxifloxacin prophylaxis was added in a step-wise fashion throughout AEH.

298 hrough a single 15 ns Dexter energy transfer step with a nearly 50% yield.

299 lar volumes varied substantially, but not in step with binding affinity, suggesting distinct modes of

300 assembling of lipid bilayers proceeds in two steps, with a slow second step occurring over many days