ライフサイエンスコーパス: stepped

1 one- (1.(H2O,EtOH)), two- (1.3H2O) and three-stepped (1.

2 y of macrocycle conformations ranging from a stepped 2 + 2 macrocycle to a multiply folded 8 + 8 macr

3 sphere adsorption to the flat {1014} and the stepped {3148} and {31216} planes of calcite.

4 found to adsorb preferentially on the acute-stepped {3148} face of calcite, in agreement with experi

5 order dendrites exiting from them generally stepped abruptly to a diameter of 0.4-0.6 micrometer, wh

6 t least two varieties of carbonates, using a stepped acid dissolution technique paired with ion micro

7 source, and a calibrated (68)Ge point source stepped across the axial field of view (FOV) provided th

8 A (68)Ge point source was stepped across the axial field of view to measure the se

9 ncidence events as a (22)Na point source was stepped across the coincidence line of response between

10 We examined the effectiveness of integrated stepped alcohol treatment (ISAT) on alcohol use and HIV

11 This resource consists of "Stepped Aligned Inbred Recombinant Strains" (STAIRS) plu

12 These sequence 'walkers' can be stepped along raw sequence data to visually search for b

13 tforms, followed by development of multitier stepped altar platforms and use of pecked basalt stones

14 framework can also undergo a combination of stepped and continuous breathing.

15 hat explain why, surprisingly, CO desorbs at stepped and flat Pt crystal planes at once, regardless o

16 ale engineering of these interlayers to form stepped and graded electronic profiles can lead to remar

17 e coupling constants: field-swept, frequency-stepped, and high-field MAS NMR.

18 entage of spinal rats per group that plantar stepped, and was the only group to significantly improve

19 smaller proportion of cells, in response to stepped application of progesterone (3 microM).

20 o treatment strategies are currently used, a stepped approach beginning with more simple care that is

21 ion trapping mass analyzers an integrative, stepped approach to spectral reconstruction is a logical

22 The end result is a structured, stepped approach using neurobiological constructs as tar

23 he possibility of improved diagnosis through stepped approaches, epitope-binding analysis, and bioinf

24 week for six weeks, in which the supervisor stepped aside and workers discussed problems, ideas, and

25 In this population-based fMRI study, we stepped back by over a decade to characterize the change

26 Properties of the derived response to a stepped background and to test flashes presented in stea

27 but not backward locomotion while two others stepped backward but not forward.

28 Lastly, spinal cats also stepped backward on a split-belt treadmill, with the lef

29 chment and detachment of a barium ion onto a stepped barite (BaSO(4)) surface.

30 m(II) complex "foot" that can be selectively stepped between 4-dimethylaminopyridine and pyridine lig

31 Purpose A stepped care (SC) program in which an effective yet leas

32 of a stepped care case-finding intervention (stepped care [SC]) vs a moderate-strength single-level i

33 zing nonopioid analgesic medications using a stepped care algorithm and monitoring.

34 s of usual care alone, usual care with SSCM, stepped care alone, and stepped care with SSCM.

35 rity categorization is essential for using a stepped care approach to asthma pharmacotherapy.

36 symptom monitoring with an algorithm-guided stepped care approach to optimizing analgesics.

37 To simulate a comparison of a stepped care case-finding intervention (stepped care [SC

38 , AND PATIENTS: Randomized controlled trial (Stepped Care for Affective Disorders and Musculoskeletal

39 Stepped care interventions can reduce PTSD symptoms and

40 Stepped care is an increasingly popular treatment model

41 In conclusion, stepped care model appeared to be better than CAU in tre

42 r "low-intensity" interventions as part of a stepped care model.

43 atients with major depression were allocated stepped care or usual care.

44 rogram (NAEPP) Expert Panel II recommended a stepped care pharmacotherapy approach to asthma treatmen

45 included in this review, of which 6 examined stepped care prevention and 4 examined stepped care trea

46 mpare the efficacy and cost-effectiveness of stepped care prevention and treatment with care-as-usual

47 No significant difference was found between stepped care prevention/treatment and CAU in preventing

48 The CC patients received stepped care that consisted of (1) continuous postinjury

49 The Stepped Care to Optimize Pain Care Effectiveness (SCOPE)

50 Results showed stepped care treatment revealed a significantly better p

51 nxiety disorders was significantly higher in stepped care treatment than in CAU.

52 mined stepped care prevention and 4 examined stepped care treatment, specifically including ones rega

53 Stepped care was a 3-month, multicomponent intervention

54 Stepped care was associated with greater reach and was s

55 sual care with SSCM, stepped care alone, and stepped care with SSCM.

56 Stepped-care and collaborative models provide a framewor

57 Stepped-care antihypertensive drug therapy, in which the

58 g the addition of a recommended standardized stepped-care antihypertensive treatment (SSAHT) to the r

59 decrease in blood pressure than standardized stepped-care antihypertensive treatment alone.

60 of renal denervation added to a standardized stepped-care antihypertensive treatment for resistant hy

61 eatment, renal denervation plus standardized stepped-care antihypertensive treatment resulted in a gr

62 igned to renal denervation plus standardized stepped-care antihypertensive treatment, or the same ant

63 For standardized stepped-care antihypertensive treatment, spironolactone

64 This stepped-care approach provides a framework for sequencin

65 This paper proposes a stepped-care approach that addresses the functional outc

66 imia nervosa and binge eating disorder, with stepped-care approaches showing promise and new behavior

67 n implemented through collaborative care and stepped-care approaches.

68 At 6-months' follow-up, 70% (60-79) of the stepped-care compared with 30% (21-40) of the usual-care

69 Specialized nurses delivered a 12-month, stepped-care depression treatment program beginning with

70 ividual counseling on a fat-modified diet, a stepped-care drug treatment program for diastolic hypert

71 h community-based workers in a collaborative stepped-care framework is an approach that is ripe to be

72 d four suicide attempts in the collaborative stepped-care group and six deaths and six suicide attemp

73 ervention group in which patients received a stepped-care intervention (eight sessions of individual

74 The collaborative stepped-care intervention offered case management and ps

75 We aimed to compare a stepped-care intervention package for depression with us

76 Intervention A stepped-care model for depression treatment was used by

77 Physicians should consider a stepped-care model in which patients may begin with rela

78 ed for initial severity, women receiving the stepped-care program had a mean of 50 additional depress

79 allocated to usual care or a multicomponent stepped-care program led by a nonmedical health care wor

80 The stepped-care program was marginally more expensive than

81 The stepped-care program was significantly more effective an

82 We aimed to compare the effectiveness of a stepped-care programme with usual care in primary-care m

83 nce in all outcome measures in favour of the stepped-care programme.

84 ed systolic hypertension with chlorthalidone stepped-care therapy for 4.5 years was associated with l

85 on and dietary reduction of cholesterol, and stepped-care therapy for hypertension.

86 pertensive therapy with chlorthalidone-based stepped-care therapy resulted in a lower rate of cardiov

87 persons with isolated systolic hypertension, stepped-care treatment based on low-dose chlorthalidone

88 r depression responded well to a structured, stepped-care treatment programme, which is being introdu

89 ared the incremental cost-effectiveness of a stepped-care, multicomponent program with usual care for

90 an primary health-care workers in Nigeria, a stepped-care, problem-solving intervention combined with

91 Limitations include the multi-stepped causal pathway from PDMP mandate implementation

92 We find that this trait underwent stepped change, from thick to semi-thin to thin seed coa

93 which can be monitored by the corresponding stepped changes in the ion current flowing through the p

94 luated the incremental cost-effectiveness of stepped collaborative care for patients with persistent

95 Stepped collaborative care intervention included motivat

96 A stepped collaborative care program for depressed primary

97 PTSD symptom levels and then randomized to a stepped combined care management, psychopharmacology, an

98 communication in the HKR is mediated by the stepped conformation of the salen ligand, and not the sh

99 lation exhibited a canonical anticodon stair-stepped conformation.

100 ification during the middle Pliocene, sudden stepped cooling events during the Pliocene-Pleistocene t

101 ommunity that inhabited the mountains before stepped cooling that first brought a full polar climate

102 d 17,143 children admitted during the 2-year stepped crossover period (November 2015 to October 2017)

103 ntrated and selectively released by applying stepped DC voltages across a microchannel containing an

104 The stepped decline is argued to reflect marine downdraw tri

105 ter delta(13)CDIC, the last of a longer-term stepped decrease through the Spathian.

106 received anterior chamber (AC) injections of stepped doses (10(6)-10(8) transduction units) of lentiv

107 col at a lower total dose (0.5-5.0 mSv, with stepped doses of 0.5 mSv).

108 of a block, 20 long-term multifocal wearers stepped down (from different block heights) onto a lower

109 rol and reduce the risk of exacerbations and stepped down after a period of prolonged control.

110 Exposed patients were stepped down by dropping their LABAs or another add-on o

111 89.4% (95% CI, 86.4% to 92.4%) of those who stepped down had preserved asthma control compared with

112 , and the treatment for bronchial asthma was stepped down without any recurrence of asthma attacks.

113 After 4 days in ICU he was stepped down, and discharged after a further 10 days wit

114 on: mean age 50.4 years, 39.4% males, 39,881 stepped down.

115 Following withdrawal of the stepped-down 0.5 mg dose and consequent release into a f

116 In addition, distinct stepped expression levels of hunchback in the gnathal/th

117 , absolute bias of 0.54% to the standardized stepped field (DT)CCSN2 values on the reference system.

118 The traditional stepped field CCS method performs with a relative standa

119 A set of images was recorded at stepped focus settings and analyzed to find the sharpest

120 5-853 kcal/day formula diet for 3-5 months), stepped food reintroduction (2-8 weeks), and structured

121 kcal per day formula diet for 12-20 weeks), stepped food reintroduction (2-8 weeks), and then struct

122 Three trained and three nontrained rats stepped for 1 h (ES; no quipazine) and were returned to

123 ith similar benefits and adverse effects, a "stepped formulary" approach requiring an initial trial o

124 methods based on nucleic acid amplification stepped forwards owing to their high sensitivity, specif

125 This segmentation produces stepped fracture surfaces with characteristic 'lance-sha

126 When cells were stepped from -100 to -30 mV in Ca2+-free conditions, sma

127 0) and Scheme 2 where the potential is again stepped from E(start) to E(step) to oxidize A to B under

128 ral schemes: Scheme 1 where the potential is stepped from E(start) to E(step) to oxidize the initiall

129 me liposome-based drug products have already stepped from the lab-bench to the market.

130 a, mood changes, urinary symptoms, and short-stepped gait.

131 ge of glucose concentrations, responses to a stepped glucose infusion were measured in 23 subjects.

132 The response of the CMHs to a stepped heat stimulus (49 degrees C, 3 s) was either qui

133 llion extraterrestrial H(2)O released during stepped heating.

134 Stepped-heating experiments on martian meteorites Allan

135 age, where {100} facets roughen into vicinal stepped high Miller index facets, while {111} facets rem

136 Kinked-stepped, high Miller index surfaces of metal crystals ar

137 l glucose reabsorption was measured with the stepped hyperglycemic clamp in 15 subjects with type 2 d

138 hed for age, sex, and body mass index with a stepped hyperinsulinaemic hypoglycaemic glucose clamp.

139 Using functional MRI (fMRI) combined with a stepped hyperinsulinemic euglycemic-hypoglycemic clamp a

140 placebo-controlled cross-over trial using a stepped hyperinsulinemic hypoglycemia clamp was performe

141 ted type 1 diabetic subjects participated in stepped hyperinsulinemic- (2 mU x kg(-1) x min(-1)) eugl

142 ter intrahepatic islet transplantation using stepped hyperinsulinemic-hypoglycemic and paired hyperin

143 On day 2, all were studied with stepped hyperinsulinemic-hypoglycemic clamps, using horm

144 Using stepped hypoglycemia clamp studies (5.0, 4.4, 3.9, and 3

145 reatic polypeptide (P = 0.0046) responses to stepped hypoglycemia were reduced significantly, and sym

146 and cognitive responses to hyperinsulinemic stepped hypoglycemic (4.7, 4.2, 3.6, 3.0, 2.8, 2.5, and

147 hyperinsulinemic (2.0 mU x kg(-1) x min(-1)) stepped hypoglycemic (85, 75, 65, 55, and 45 mg/dl) clam

148 and during euglycemic-hyperinsulinemic then stepped hypoglycemic (hourly steps at 85, 75, 65, 55, an

149 ched control subjects were studied utilizing stepped hypoglycemic clamp protocol to achieve target gl

150 We performed stepped hypoglycemic clamp studies in successful pancrea

151 Hyperinsulinemic stepped hypoglycemic clamps (85, 75, 65, 55, and 45 mg/d

152 ere assessed during morning hyperinsulinemic stepped hypoglycemic clamps (85, 75, 65, 55, and 45 mg/d

153 betic control subjects with hyperinsulinemic stepped hypoglycemic clamps (glucose steps of approximat

154 On day 2, subjects underwent stepped hypoglycemic clamps (nadir 60 mg/dL) with evalua

155 Consequently, we performed stepped hypoglycemic clamps in 7 donors of varying glyce

156 subjects were studied with hyperinsulinemic-stepped hypoglycemic clamps the day after saline or cort

157 ction tests deteriorated (P < 0.0001) during stepped hypoglycemic clamps, but there were no significa

158 ps of pancreas transplant recipients using a stepped hypoglycemic, hyperinsulinemic clamp.

159 approximately 5 years earlier using the same stepped, hypoglycemic clamp technique.

160 Participants unknowingly stepped in circles opposite to the direction of the prio

161 s is fraught with challenges, and often side-stepped in favour of studying the function of different

162 Twelve healthy participants stepped in place on the axis of a rotating surface rangi

163 nucleus to a vertical bar stimulus that was stepped in small increments through the receptive fields

164 e observed by 7 d, when only trained KO mice stepped in the open field.

165 orescence emission red shift and an apparent stepped increase in fluorescence intensity.

166 screening mammography increased, yielding a stepped increase in women recalled per cancer detected f

167 interventions led to smaller but significant stepped increases compared with the automated interventi

168 only partially updated when measured against stepped increases in PEs.

169 their evaluations of pain in relation to the stepped increases in prediction errors.

170 (somatostatin/glucagon/growth hormone) with stepped insulin levels.

171 ation of artificial nanofluidic devices have stepped into a completely new stage, termed 2D nanofluid

172 A gunman with a semiautomatic weapon stepped into a tourist coffee shop and systematically sh

173 ieved, crop functional genomics studies have stepped into the big-data and high-throughput era.

174 sual care), pulse oximetry introduction, and stepped introduction of a multifaceted oxygen system.

175 re the effect of a targeted, low-burden, and stepped invitation strategy versus control on uptake of

176 reas beta-RbBi(3)Se(5) and CsBi(3)Se(5) have stepped layers with alkali metal ions found disordered i

177 clinical decision making that involves four stepped levels, proceeding from the lowest to the highes

178 ful symptom relief and low mortality through stepped management, adding disopyramide in appropriately

179 still survive with an anisotropic etched and stepped nanotip at temperatures up to 800 degrees C, muc

180 Monkeys tracked a target that stepped obliquely away from the point of fixation, then

181 Demonstrator pigeons (Columba livia) stepped on a treadle in the presence of 1 light and peck

182 The response to stepped onset of an approximately half-saturating backgr

183 , and persistent congestion to a strategy of stepped pharmacologic therapy (94 patients) or ultrafilt

184 ion, and persistent congestion, the use of a stepped pharmacologic-therapy algorithm was superior to

185 xisting WRF to intensive volume removal with stepped pharmacological therapy or fixed rate ultrafiltr

186 on did not differ by mode of volume removal (stepped pharmacological therapy versus ultrafiltration,

187 Here we describe a two-stepped photobiotin-based procedure to enrich a target (

188 tation is presented for the magnetism of the stepped pi-chain of 2 using an alternating Heisenberg ch

189 structure and geometry optimizations on the stepped pi-chain, the isolated molecule and (di)cations

190 We found that stepped platinum (Pt) surfaces can undergo extensive and

191 tions, we study the adsorption of water on a stepped platinum surface.

192 ce of 61 pS was found when the Cx43 cell was stepped positively or the Cx40 cell negatively (V(j)=70

193 o adequately resolve by means of traditional stepped potential protocols.

194 a recombinant human construct Eg5-513-5His, stepped processively along microtubules in 8-nm incremen

195 strated behavior of water chains adsorbed on stepped Pt surfaces to transfer protons via thermally ac

196 at are otherwise invisible when conventional stepped pulses are applied.

197 opriate samples is evolved by a procedure of stepped pyrolysis (0-1000 degrees C, typically in 50 deg

198 t will be shown that nitrogen formation on a stepped rhodium surface is a dynamic interplay of atomic

199 (stationary spot) revealed Ca2+ sparks with "stepped' rises, consistent with multiple sites of origin

200 Both groups received a stepped sequence of preinvitation, invitation, and remin

201 For the dihydride-stepped Si(111) surface, a unique reaction pathway is id

202 tionally, extra curing induced protruding or stepped sidewalls under high printing speed, which requi

203 eward loads, we found that individual motors stepped sideward in both directions, with and against lo

204 n this article we predict theoretically that stepped silicon surfaces stabilized by adsorbed gold ach

205 Stepped single-crystal surfaces are viewed as models of

206 in contrast to typical N(2) dissociation on stepped sites adopted by Ru-Cs counterparts, giving new

207 ding that are distinct from the terraces and stepped sites found on polycrystalline Cu foil.

208 oreover, the [Cu2(glu)2(bpa)] MOF displays a stepped sorption isotherm for the uptake of CO2 at room

209 on of the electrode and employing a coarsely stepped squarewave voltammetry, a technique which is app

210 ered cubic metals such as Cu have kinked and stepped structures which are nonsuperimposable mirror im

211 hoosing an appropriate fold pattern a target stepped surface can be designed.

212 late transition metals can modify binding at stepped surfaces opposite to well-established trends on

213 a characteristic elastic strain variation at stepped surfaces, and unveil subtle stress-release effec

214 tle is known about the chemistry of water on stepped surfaces, commonly occurring in realistic situat

215 omains along the terraces of atomically flat stepped surfaces.

216 ease in amplitude to go directly to the back-stepped target location.

217 Lower olefins are produced at promoted (stepped) terrace sites that are available and active, qu

218 pontaneous release; and when the voltage was stepped to >-40 mV, secretion ensued.

219 Cells were voltage clamped at -30 mV and stepped to -120 mV in 10 mV steps of 2 s duration.

220 Using a moving pursuit stimulus that stepped to a new spatial location just before a targetin

221 In this method, the applied force is rapidly stepped to a new value and either the unfolding or refol

222 med, it persists even after the potential is stepped to higher values (0.5-0.8 V(SCE)).

223 When the outer segment of the cone was stepped to low-Ca(2+)-O Na+ solution before the bleach w

224 currents were restored when the patches were stepped to negative potentials.

225 lamp mode, the cells were held at -60 mV and stepped to values from -60 to 80 mV.

226 time scale than unfolding and involves sharp stepped transitions.

227 2) vs standard (n=247) treatment groups with stepped treatment algorithms defined for both.

228 to specialty centers or for the selection of stepped treatment algorithms.

229 f our findings and further assessment of the stepped treatment model is warranted.

230 Stepped-treatment approaches customize interventions bas

231 f linear and rotary motors, and explains the stepped unidirectional rotary motion.

232 Participants were stepped up at weeks 4 and 12 if they exceeded a priori d

233 Thus, we have stepped up the computational strategy using a protocol b

234 dates that asthma treatment is progressively stepped up to achieve symptom control and reduce the ris

235 ntinue to increase as the CO2 enrichment was stepped up to higher concentrations.

236 Vaccination needs to be stepped up to protect persons who remain at risk of HBV

237 e arm, of those with 6 months recurrence who stepped up treatment, 18 (38%) of 47 patients were in re

238 We show how these actions can provide a stepped-up basis for additional federal action to reduce

239 ented global warming, only extraordinary and stepped-up conservation efforts will prevent a new round

240 5 V) from the biofuel cell is converted to a stepped-up power and charged to the capacitor to the vol

241 ipants randomized to receive MTX monotherapy stepped-up to combination therapy at 24 weeks if the Dis

242 Rutgeerts score >/=i2) at 6 months, patients stepped-up to thiopurine, fortnightly adalimumab with th

243 s with endoscopic recurrence at 6 months who stepped-up treatment, FC levels decreased from 324 mug/g

244 patients in the active care group, 47 (39%) stepped-up treatment.

245 The advantage of stepped vitrification (SV) is avoiding ice crystal nucle

246 orbidity and length of in-hospital stay in a stepped wedge cluster randomized controlled trial conduc

247 This was a pragmatic stepped wedge cluster randomized controlled trial evalua

248 A stepped wedge cluster randomized controlled trial was co

249 A multicenter stepped wedge cluster randomized controlled trial.

250 rapy with RUTF (992 children) according to a stepped wedge design to control for bias introduced by t

251 ects of this program in ICU patients using a stepped wedge design.

252 designs: parallel-arm, ring vaccination, and stepped wedge designs.

253 ment (n = 74) or 28 days later (n = 77) in a stepped wedge fashion, allowing comparisons between reci

254 Stepped wedge trials allow investigators to estimate CAC

255 using the IV approach, which are testable in stepped wedge trials but not in parallel-arm trials.

256 While new methods for analyzing stepped wedge trials can provide some improvement over p

257 , however, methods generally used to analyze stepped wedge trials might not perform well in these set

258 Despite the value of new methods, stepped wedge trials still have statistical disadvantage

259 Inclusion of CACE estimates in stepped wedge trials with imperfect compliance could enh

260 ding recently proposed methods for analyzing stepped wedge trials, to determine the statistical prope

261 e a method for estimating CACE in randomized stepped wedge trials, where experimental units cross ove

262 This was a multicenter pragmatic stepped-wedge before-and-after trial in 7 New Zealand ac

263 DESIGN, SETTING, AND PATIENTS: Prospective stepped-wedge clinical practice study of 6290 adults adm

264 This is a secondary analysis of a stepped-wedge cluster randomised controlled trial undert

265 A stepped-wedge cluster randomised trial was conducted in

266 By using a stepped-wedge cluster randomized and controlled trial de

267 We conducted a stepped-wedge cluster randomized controlled trial in 12

268 We conducted a pragmatic multicenter stepped-wedge cluster randomized controlled trial of a p

269 A stepped-wedge cluster randomized quality improvement stu

270 on-wide implementation of this strategy in a stepped-wedge cluster randomized trial (NCT01960972).

271 DESIGN, SETTING, AND PARTICIPANTS: Stepped-wedge cluster randomized trial in 15 EDs in Fran

272 DESIGN, SETTING, AND PARTICIPANTS: Stepped-wedge cluster randomized trial of 2494 adults ho

273 A multicenter, pragmatic, stepped-wedge cluster randomized trial was performed in

274 In a stepped-wedge cluster randomized, controlled trial, we i

275 wer of randomised controlled trial (RCT) and stepped-wedge cluster trial (SWCT) designs in Sierra Leo

276 We conducted a stepped-wedge cluster-randomised controlled trial (RCT)

277 We did a multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial in 11

278 We conducted a stepped-wedge cluster-randomised controlled trial in Esw

279 over three years in central Senegal using a stepped-wedge cluster-randomised design.

280 We conducted an unblinded stepped-wedge cluster-randomised trial comparing three s

281 We did a stepped-wedge cluster-randomised trial of patients aged

282 d a cluster-randomised controlled trial with stepped-wedge cohort design in 6 Norwegian municipalitie

283 Using a stepped-wedge design, we tested whether a bundled interv

284 lly randomized group treatment trial and the stepped-wedge group-randomized trial.

285 The QI package was implemented in a stepped-wedge manner with a delay of three months for ea

286 dship audit-and-feedback intervention, via a stepped-wedge randomized trial.

287 ing rollout of the P4P program to simulate a stepped-wedge study design.

288 In this cluster-randomized, stepped-wedge trial conducted in Tayside, Scotland, we r

289 In a pragmatic, cluster-randomized, stepped-wedge trial with 2 time periods of observation,

290 Stepped-wedge trial.

291 orm the trial design of future international stepped-wedge trials.

292 Stepped-wedge, cluster randomized trial.

293 We did a pragmatic, stepped-wedge, cluster-randomised controlled trial in te

294 d acute coronary syndrome were enrolled in a stepped-wedge, cluster-randomized controlled trial acros

295 A stepped-wedge, cluster-randomized trial was conducted in

296 We conducted a stepped-wedge, community-level randomized trial to deter

297 In this stepped-wedge, non-blinded, cluster-randomised controlle

298 We did a pragmatic, two-step, stepped-wedge, randomised controlled trial at 18 sites g

299 Once north of the caldera, the eruption stepped westward, and a dike propagated along the extens

300 However, on the ground neonates stepped with fewer temporal patterns but all structured