ライフサイエンスコーパス: straightforward

1 able software makes the assessment procedure straightforward.

2 s using cell biological and genetic tools is straightforward.

3 urement of BBB permeability in humans is not straightforward.

4 ry statistics from these files is not always straightforward.

5 ose reliable characterization however is not straightforward.

6 agnosis of long QT syndrome (LQTS) is rather straightforward.

7 mple, and data collection and processing are straightforward.

8 lem in analytical chemistry, and it is never straightforward.

9 re efficient, inexpensive, and operationally straightforward.

10 noma screening from in vitro to ex vivo more straightforward.

11 ap between two populations is, in principle, straightforward.

12 irical results and ecological theory are not straightforward.

13 vity of diverse single-atom catalysts is not straightforward.

14 adenosine nucleotide analogues is rapid and straightforward.

15 c passage problems in more-level systems are straightforward.

16 reactions has allowed interesting and highly straightforward access to a variety of building blocks f

17 ivity in protonation, and enabled simple and straightforward access to complex deuterium-labeled comp

18 ies from a variety of radical precursors and straightforward access to hydropersulfides.

19 The developed protocol enables the easy and straightforward access to several high-value beta-aryl-b

20 reoselective synthetic protocols that enable straightforward access to these building blocks.

21 on and pathology of peripheral myelin, and a straightforward, accurate and sensitive workflow to addr

22 targeted lead structure, allowing relatively straightforward adaptation to the different structural r

23 The interface is a straightforward addition to commercially available techn

24 A straightforward alkali-metal-mediated hydroamination of

25 q2-clawback provides a straightforward alternative for samples from common envi

26 sis of an early pregnancy loss is relatively straightforward, although progress in predicting and pre

27 Straightforward analog-to-digital signal conversion does

28 ble instruments in applications that require straightforward analyses with no consumables.

29 However, straightforward analysis of this data does not provide o

30 We apply this in a straightforward analytical method, persistent associatio

31 This new alkylation method is fast and straightforward and allows for the direct introduction o

32 Our optimized in-solution workflow is straightforward and also much less equipment- and techni

33 Sample preparation for our device is also straightforward and appropriate for field deployment, re

34 This straightforward and atom-economical strategy can provide

35 To address these challenges, we developed a straightforward and comprehensive analytical methodology

36 This method provides a straightforward and convenient approach for the synthesi

37 Our system provides a straightforward and cost-effective approach for high eff

38 These straightforward and cost-effective designed systems can

39 This straightforward and cost-effective methodology for quant

40 To develop a straightforward and cost-effective platform for assessin

41 We envision the use of this approach as a straightforward and cost-effective strategy to improve t

42 Here we report a straightforward and cost-efficient strategy to develop J

43 AutoDock Bias is a straightforward and easy to use script-based method that

44 ally protected or free amines, render this a straightforward and effective approach for the preparati

45 A straightforward and efficient method was developed by ul

46 ralized linear mixed-effects models (GLMMs), straightforward and efficient one-step procedures for fi

47 esign strategy is anticipated to form a more straightforward and efficient paradigm for practical app

48 We report a straightforward and efficient Pd/enamine catalytic proce

49 article occlusion within crystals provides a straightforward and efficient route to make new nanocomp

50 This multicomponent reaction provides a straightforward and facile pathway for the synthesis of

51 ogenating system (R(4)NHal/NOHSO(4)), giving straightforward and general access to halogenated 3,5-di

52 By demonstrating the veracity of this straightforward and inexpensive sampling method, we prov

53 an expansion of the synthetic scope of this straightforward and inherently environmentally friendly

54 Our model is straightforward and intuitive.

55 The complete experimental protocol is straightforward and lays a foundation for future explora

56 iastereo- and regioselectively proceed under straightforward and mild conditions.

57 called boron-Wittig reaction, allows for the straightforward and often stereoselective formation of s

58 This methodology is conceptually straightforward and readily implemented, and can be broa

59 Our tool allows the straightforward and reproducible simulation of bacterial

60 ting up and running these simulations is not straightforward and requires expert knowledge.

61 mating the index of this type of lens is not straightforward and requires substantial iterative compu

62 Thus, junctured-DNA tweezers allow a straightforward and robust access to single-molecule for

63 CytoCensus opens the possibility of straightforward and robust automated analysis of develop

64 As a straightforward and robust technique to determine nonaqu

65 A straightforward and scalable methodology to synthesize d

66 Together, glyoxalation is a straightforward and scarless method for imparting revers

67 A straightforward and selective reduction of nitroarenes w

68 ed electrochemical biosensors, yet in a more straightforward and sensitive way following green chemis

69 entrations and is generally considered to be straightforward and trouble free.

70 It provides a straightforward and user-friendly platform for performin

71 Here, a straightforward and well-controlled one-pot synthesis of

72 rview participants considered their decision straightforward and were satisfied with their decision w

73 Simple, straightforward, and atom economic methods for the synth

74 ow the outcomes of these transitions are not straightforward, and how environmental context strongly

75 (GFE) are developed by a one-step, low-cost, straightforward, and mass-producible method, and are sea

76 all, these advances allow for a more robust, straightforward, and safe instrumentation platform, perm

77 We have developed a detailed, straightforward, and scalable method to deliver shRNAs i

78 f which the fabrication processes are rapid, straightforward, and translatable to industrial mass pro

79 ith rest congestion, where diagnosis is more straightforward; and (2) individuals with exercise intol

80 out the sex ratio have always seemed to have straightforward answers, which on closer inspection turn

81 estions for which there have not always been straightforward answers.

82 rization for exons and introns (MEI), is its straightforward applicability to existing archived data

83 The straightforward applicability without the need for any s

84 To address this issue, we proposed a straightforward approach by combining active plasmonic n

85 This mild and straightforward approach involves in situ formation and

86 This study represents a straightforward approach to design new targeted peptides

87 with neuronal tracers not only represents a straightforward approach to identify axonal projection c

88 anation of olefins represents a conceptually straightforward approach to prepare enantiomerically enr

89 f ionizable groups represents a powerful yet straightforward approach to probing complex systems.

90 A straightforward approach to the synthesis of two differe

91 This study provides a simple and straightforward approach toward engineering light-weight

92 ycloaddition of 2H-azirines with nitrones, a straightforward approach toward the regioselective synth

93 No freely available tools provide straightforward approaches for consistent, flexible meta

94 lable chemical feedstock, is one of the most straightforward approaches for the synthesis of three-di

95 Resolution of Pol II blocking can be as straightforward as temporary backtracking and transcript

96 atures related to drug effects is not always straightforward as the complex TMS-EEG induced response

97 However, tuning such systems is not straightforward, as aligning the frontier orbitals to E(

98 chniques, and their relative ranking, is not straightforward, as the interactions between the environ

99 he potential of this new methodology for the straightforward assembly of chiral building blocks such

100 s calculator, a comprehensive, flexible, and straightforward assessment approach that provides an eas

101 riles via C-H/N-H bond activation, providing straightforward atom-economic access to a wide variety o

102 lar comonomers represents the seemingly most straightforward, atom- and energy-efficient approach for

103 We establish a straightforward batch approach for synthesizing uniform,

104 otential inclusion in anti-tau trials may be straightforward because the only independent predictor o

105 While conceptually straightforward, both approaches lead to problems in pra

106 An efficient and straightforward Bronsted-acid mediated cascade process w

107 This model constitutes a straightforward but highly reliable tool for isolating t

108 his microfluidic device provides a rapid and straightforward capturing and quantification method to a

109 The enantiomer-specific activity and straightforward chemical synthesis of (unnatural) ent-(+

110 , FloChIP's interconnected design allows for straightforward chromatin reimmunoprecipitation, which a

111 The dendrimer synthesis entails straightforward click coupling followed by an amidation

112 Therefore, we have developed a quick and straightforward collagenase-based enzymatic method to re

113 ies into a single codebase and to facilitate straightforward comparison and adoption of different app

114 lock-polymer phase behavior is governed by a straightforward competition between chain stretching and

115 We therefore developed a generalizable, but straightforward computational method to handle arbitrari

116 ce (CoGEF) method is a highly accessible and straightforward computational technique that simulates t

117 Considering the straightforward conditions for both the installation and

118 A straightforward conservation analysis of MSAs composed o

119 The straightforward construction of the stereogenic axis by

120 de material-based NPs (defined as LCD NP) is straightforward, cost-effective, and scalable.

121 and the (2)D HILIC column dimension allowed straightforward coupling of HILIC for both IPRP and AEX

122 run several experiments in parallel, and (5) straightforward data analysis.

123 ombine deep mutational scanning (DMS) with a straightforward data processing step to bridge reads in

124 onization protocol that enables a particular straightforward derivatization of unsaturated lipids in

125 with the valence hole (H(2)O(+)/OH) enabled straightforward detection.

126 osed benchtop approach is cost-effective and straightforward, does not require sophisticated faciliti

127 The isolation of the reaction products is straightforward due to the lack of solvents and a high p

128 Our approach is straightforward, easy to implement, and enables quantita

129 use computational workflows, STRIPE-seq is a straightforward, efficient means by which to probe the l

130 Herein, a straightforward electrochemical approach for the determi

131 A straightforward energetic parameter explains the experim

132 ombination of these two procedures affords a straightforward entry to diarylated hydantoins.

133 how the model can be used in reverse, where straightforward experiments measuring the activity of an

134 major depressive disorder and discuss STIR's straightforward extension to genome-wide association stu

135 This study reports a straightforward fabrication technique for patterning an

136 Straightforward family-wise correction (Bonferroni) of p

137 This straightforward framework provides the basis for transla

138 Our work highlights the utility of our straightforward genetic screening method in identifying

139 menting optogenetics in plants has been less straightforward, given their dependency on light for the

140 Here, a straightforward heterogeneous interfacial method to deve

141 We expect that this relatively straightforward, homogeneous assay can be widely used fo

142 Designing such processes is hardly straightforward, however, especially when the desired ro

143 he storage and analysis of query results are straightforward; however, for complex queries, these cap

144 concept experiments, the approach led to the straightforward identification of a new thiosemicarbazon

145 ninvasive monitoring of Th2 polarization and straightforward identification of innate lymphoid cell 2

146 ection platform is described that allows for straightforward identification of transcriptional regula

147 ns of the analytic solutions are found to be straightforward if a combination of the source function

148 We anticipate that the straightforward implementation of autoPOTS will make it

149 pointspread function of the sensor enables a straightforward implementation of super-resolution techn

150 le the interpretation of a shortest paths is straightforward in binary, unweighted networks, whenever

151 Diagnosis is straightforward in most patients with typical symptoms a

152 While straightforward in principle, experience has shown that

153 gnosis of Hymenoptera venom allergy (HVA) is straightforward in the majority of patients, but can be

154 This technology allows straightforward incorporation of multiple functional com

155 ) The ease of peptide preparation allows for straightforward incorporation of unnatural amino acids a

156 e-beam and multibeam SEM workflows should be straightforward, increasing reliability while improving

157 he outstanding structure-directing effect of straightforward inorganic counteranions in solution on t

158 ULTS: We present a framework that allows the straightforward integration and simulation of SBML repre

159 oblem of toxicity and simultaneously achieve straightforward integration of complimentary devices to

160 ualisation post-discovery, SV-Pop allows for straightforward integration of multi-population analysis

161 FAIMS resolution using solely N(2) and thus straightforward integration with any MS platform: here O

162 The straightforward interpretation of these data suggests th

163 A straightforward interpretation of these findings is that

164 Using behavioral modeling, we show that the straightforward intuition that these tasks just probe sp

165 n of an external calibration method to allow straightforward laboratory and field measurement of (*)O

166 This new assay now enables straightforward large-scale screening for PSD inhibitors

167 A sensitive and straightforward LC-IT-TOF-MS method was validated for th

168 Facilitated cascade testing is a straightforward, low-cost, easily implemented strategy w

169 lows for control of product distributions by straightforward manipulation of reaction conditions (e.g

170 th different substituents were prepared in a straightforward manner through indole- and benzo[b]thiop

171 a single mediator cannot be generalized in a straightforward manner to high-dimension mediation.

172 ructural buckling, can all be predicted in a straightforward manner.

173 her conformational searching strategies in a straightforward manner.

174 ralized calibration, which is capable of the straightforward mapping of retention time models between

175 SPIM systems, SPIM-FRAP is set to provide a straightforward means of quantifying the spatial distrib

176 y photon losses and cannot be extended using straightforward measure-and-repeat strategies without co

177 ariant at the molecular level, demonstrate a straightforward mechanical agitation-based methodology f

178 This operationally straightforward, metal-free and modular transformation f

179 Laser writing as a simple and straightforward method for covalent 2D patterning of gra

180 osed of cation selective membranes provide a straightforward method for enhancing cathode reversibili

181 Nanopore reads can be used to implement a straightforward method for error correction that reduces

182 We present a straightforward method for extending the duration of a s

183 FFPEcap-seq is a fast and straightforward method for making high-quality 5' end RN

184 A straightforward method for ring opening of donor-accepto

185 ounds emerged over the last two decades as a straightforward method for the formation of C(sp(3))-C(s

186 A general and straightforward method for the synthesis of COO-BODIPYs

187 Here we report a robust and straightforward method for the whole-plant live imaging

188 An efficient and straightforward method has been developed for the synthe

189 Here, a straightforward method to de-dope PEDOT:PSS using commer

190 Beyond map comparison, GROmarhos provides a straightforward method to detect solvent cavities and av

191 Here, we developed a straightforward method using self-packed capillary porou

192 We foresee that this straightforward method will gain wide acceptance for PET

193 We introduce here a straightforward methodology based on the simultaneous an

194 In this report, we present an efficient and straightforward methodology to access bicyclic carbo- an

195 Concurrently, straightforward methods for testing the invasion criteri

196 tative ee sensing with good accuracy using a straightforward mixing protocol and subsequent circular

197 pid complexes in the gas phase and provide a straightforward model to explain the results of several

198 iCTeC) device for microbial imaging-based on straightforward modifications of the typical slide-sampl

199 This offers a straightforward molecular basis for NPA inhibition of PI

200 ative conditions are lacking, we developed a straightforward NMR approach termed hydrogen/deuterium e

201 information encoded in 3D image data into a straightforward numerical representation.

202 successfully assembled to AzaBPDI using this straightforward one-pot synthesis starting from the easi

203 The methods available are either not straightforward or not sensitive enough, limiting their

204 -dependent enzymes for (2)H-labelling is not straightforward, owing to difficulties in supplying a su

205 The straightforward oxidation of electron-rich arenes, namel

206 Herein, we created a simple, rapid, and straightforward papertronic 4- and 16-channel sensing pl

207 We describe a straightforward paradigm of temporal fate specification

208 upies the active site of LpxH, foretelling a straightforward path for rapid optimization of this clas

209 Using straightforward PCR amplifications, Sanger sequencing an

210 However, this conceptually straightforward plan led to unexpected results.

211 ulfonyl flavanones is described by a one-pot straightforward POCl(3) mediated intermolecular (5 + 1)

212 Csp(2)-Csp(2) bond-forming reaction opens a straightforward pot-, atom-, step-, and energy-economic

213 ments of the signal-to-noise ratio, enabling straightforward ppb detection of low-level target compon

214 Advanced herein is a straightforward, practical, and transition-metal-free as

215 advances enable the rapid and experimentally straightforward preparation of complex oligosaccharide u

216 ent and practical synthetic strategy for the straightforward preparation of diverse and valuable amin

217 his coupling lends complexity to a seemingly straightforward problem.

218 development of IoE, and their functionality, straightforward processing and unmatched versatility mak

219 Moreover, our study describes a straightforward protocol for elucidating the physiologic

220 A straightforward protocol toward pharmacologically releva

221 Nested resampling adds a straightforward quality-control step for interpreting th

222 t the peptide level is relatively common and straightforward, quantification at the residue level is

223 er, analytical methods for comprehensive and straightforward quantitative profiling of these metaboli

224 oving stimulus within retinotopic maps for a straightforward read-out by downstream areas.

225 This straightforward regulatory strategy ensures CDK7 activat

226 Contrastingly, we demonstrate a straightforward relationship between poison-induced indi

227 ng of biomineralization and (ii) it offers a straightforward route for the preparation of novel nanoc

228 Together, these phenomena suggest that straightforward rules drive incredible neuronal complexi

229 oods provides both a prototype effective and straightforward sample preparation protocol and delivers

230 Ultimately, this study presents a straightforward, scalable framework for interrogating th

231 A straightforward, scalable synthetic route gives access t

232 for endogenous protein manipulation that is straightforward, scalable, and highly flexible in terms

233 ood of individual spiking patterns and has a straightforward, scalable, efficient, learnable, and rea

234 We find a straightforward scaling relationship in which the resolu

235 to a practical platform, offering simple and straightforward sensing of uranyl levels in urine, suita

236 ur in an abstract state space independent of straightforward sensory percepts.

237 ure of the parameter estimator, or else by a straightforward simulation approach.

238 arkov state models augmented with additional straightforward simulations to determine pose-specific l

239 Herein, we describe a straightforward single hot injection procedure revolving

240 te each of the three signaling pathways in a straightforward single-step analysis setup, without conc

241 In this work, we have developed three straightforward solid-phase approaches based on amide-bo

242 rization schemes and transformations, into a straightforward solution for the compression of sequenci

243 pectral or polarisation decomposition can be straightforward, spatial decomposition is inherently mor

244 ily available starting material (OEP) in two straightforward steps, albeit requiring extensive chroma

245 Conclusions A straightforward strategy based on a selective use of CMR

246 This binder-free and straightforward strategy for electrode preparation by si

247 These new approaches provide a straightforward strategy for the synthesis of functional

248 Herein, we demonstrate a straightforward strategy for the thermodynamically contr

249 We furthermore present a straightforward strategy to identify both nonbiotinylate

250 micro free-flow electrophoresis (muFFE) is a straightforward, suitable tool for microscale purificati

251 We herein report a highly straightforward synthesis of (-)-205B in just six synthe

252 A straightforward synthesis of 1-azido-2-bromo-1,1,2,2-tet

253 enative N-C bond forming reaction allows the straightforward synthesis of a natural product like isoi

254 A straightforward synthesis of a series of previously unkn

255 Herein, a straightforward synthesis of azetidine-3-amines, startin

256 The straightforward synthesis of N,N-disubstituted formamide

257 In this work, a novel strategy for the straightforward synthesis of substituted phthalimides is

258 g materials (HTMs) were prepared following a straightforward synthetic route by cross-linking arylami

259 We developed a straightforward synthetic route to convert nucleophilic

260 sent a conceptually novel and experimentally straightforward technique for selective analyte detectio

261 ensional techniques, MALDI/ToF MS provides a straightforward technique that can be applied to other p

262 However, the lack of a straightforward technique to characterize the local stru

263 Herein, via a straightforward template method, it is reported that suc

264 antifying the robustness of a design is less straightforward than quantifying the robustness of produ

265 It is straightforward that, for choosing a specific cancer tre

266 The temporal coding is straightforward: the spikes are distributed according to

267 es is described, which consists of a one-pot straightforward three-step synthetic route, including (i

268 coupled with in-situ derivatization was more straightforward (three steps) and sensitive, with a limi

269 and BD2 of all family members would be more straightforward to achieve.

270 We have found this approach straightforward to apply to other organisms and highligh

271 arametric bounds for the risk difference are straightforward to calculate and make no untestable assu

272 Whereas it is straightforward to compare the relative genomic distribu

273 PTC1 and PTC2 are relatively straightforward to compute and add information beyond tr

274 e for COX2, which is absent in platelets, is straightforward to demonstrate.

275 epeats (TPRs) and ankyrin repeats makes them straightforward to dissect and redesign.

276 sts of animal activities, although it is not straightforward to do so.

277 thin core and feature tables, which makes it straightforward to extend for future purposes.

278 The methods employed are straightforward to extend to processes other than the ce

279 for this assay are well-developed, it is not straightforward to extract binding constants from the re

280 The proposed Fibonacci fibers are simple and straightforward to fabricate and have a rich set of prop

281 The method is straightforward to implement and enables detection and c

282 hough simple spectra of single chemicals are straightforward to interpret (both visually and via algo

283 ides a robust and sensitive signal, which is straightforward to interpret without electrical models.

284 e motivations of behaviour, not so simple or straightforward to interpret.

285 While it is rather straightforward to measure calcium levels and contractib

286 These sulfinate reagents are straightforward to prepare, stable to storage and coupli

287 nt- and fragment-ion arrival times provide a straightforward topology identification.

288 The GUI provides a straightforward two-dimensional (2D) rendering of a glyc

289 We developed a straightforward U-DNA sequencing method (U-DNA-Seq) that

290 Here we present a straightforward unique molecular identifier (UMI)-linked

291 Stokes-Einstein relation, which eliminates a straightforward use of protein mobility as a marker of m

292 onfirm and monitor PCR, and the absence of a straightforward, user-friendly tool for monitoring PCR.

293 formation onto a "translatability grid" as a straightforward, visual guide for GRI development.

294 Calculations with these equations provide a straightforward way of determining whether emitted dropl

295 eloped in the present work rationalizes in a straightforward way the biphasic oxidation kinetics of Y

296 niche modelling reproducibility, offering a straightforward way to balance efficiency and accuracy.

297 ication down to the lower attomol range in a straightforward way without any prior enrichment or frac

298 However, diagnosis is straightforward when the highly specific serum aquaporin

299 We describe 10 straightforward writing tips-and a web tool, PubReCheck-

300 Herein, we report a straightforward, yet versatile approach to efficiently e