ライフサイエンスコーパス: stratum corneum

1 because of poor drug penetration across the stratum corneum.

2 inated by the heterogeneous structure of the stratum corneum.

3 mide structures could be elucidated in human stratum corneum.

4 ses appear to be free to act only within the stratum corneum.

5 h comprise approximately 50% of the lipid in stratum corneum.

6 eramides, an integral lipid component of the stratum corneum.

7 mained bound to a thiol-rich band within the stratum corneum.

8 by complete absence of a granular layer and stratum corneum.

9 s for the 5-fold thickening of the Abca12-/- stratum corneum.

10 d stratum granulosum, and a non-keratinizing stratum corneum.

11 also disrupted, producing a poorly developed stratum corneum.

12 istinct stages: spinous, granular layer, and stratum corneum.

13 s of these agents on the lipid matrix of the stratum corneum.

14 ophil-rich microabscesses formed beneath the stratum corneum.

15 ocytes and in the intercellular space of the stratum corneum.

16 f natural moisturizing factors (NMFs) in the stratum corneum.

17 esence of abundant lipase activity in asebia stratum corneum.

18 ilar to that previously recorded from intact stratum corneum.

19 pidermal differentiation and enriched in the stratum corneum.

20 the recovery of the barrier function of the stratum corneum.

21 volume that can rival the volume of the dry stratum corneum.

22 meable barrier of cornified cell layers, the stratum corneum.

23 rant profilaggrin-processing products in the stratum corneum.

24 stratum corneum was 85% lower than in normal stratum corneum.

25 scopically disrupt the lipid bilayers of the stratum corneum.

26 rficial layers of the epidermis, beneath the stratum corneum.

27 the penetration efficacy of the nanogel into stratum corneum.

28 rugs can effectively permeate through intact stratum corneum.

29 elope of corneocytes in the outer layer, the stratum corneum.

30 could sustain 0.6N that is enough to pierce stratum corneum.

31 igned to create microscopic pores across the stratum corneum.

32 and an accumulation of lipid droplets in the stratum corneum.

33 nt a better way to deliver siRNAs across the stratum corneum.

34 rily distributed into, or on the top of, the stratum corneum.

35 ity results in increased water loss from the stratum corneum.

36 ncluding the intracellular components of the stratum corneum.

37 Skin grafting experiments confirmed the stratum corneum abnormalities and normal BrdU uptake.

38 of interventions with partial removal of the stratum corneum after curettage and microdermabrasion an

39 heir estimated saturation doses in the upper stratum corneum allows one to distinguish between diffus

40 Such barrier function of the stratum corneum also hampers the use of common adjuvants

41 After minimal injury to the stratum corneum alterations in the calcium concentration

42 face between a macroscopic sample of porcine stratum corneum and an adherent deformable elastomer sub

43 ton syndrome, which causes detachment of the stratum corneum and chronic inflammation.

44 tion can effectively carry siRNA through the stratum corneum and deposit it at the lower epidermis/up

45 ely, a low permeability of siRNA through the stratum corneum and epidermis has significantly limited

46 While the makeup of healthy stratum corneum and epidermis is generally understood, t

47 e the skin permeation barrier imposed by the stratum corneum and facilitate transcutaneous delivery o

48 lation has been shown to efficiently disrupt stratum corneum and facilitate transcutaneous drug deliv

49 hough immunostaining was associated with the stratum corneum and fluorescein isothiocyanate-labeled o

50 by histological analysis showing an impaired stratum corneum and higher cellular infiltration after p

51 t (1) both SRB and RBHE penetrate beyond the stratum corneum and into the viable epidermis only in di

52 e delivery of encapsulated molecules via the stratum corneum and mammary ducts in a formulation-depen

53 eposited significantly more dye via both the stratum corneum and mammary ducts, while the 80% and 70%

54 Mutant mice exhibit fragile stratum corneum and perinatal death due to dehydration.

55 lved in the physical barrier function of the stratum corneum and provide innate cutaneous host defens

56 e large anionic molecules must penetrate the stratum corneum and reach the living epidermis and dermi

57 to the cornified envelope) is present in the stratum corneum and retains the ability to form covalent

58 the observed deficit in the adhesion of the stratum corneum and the severely compromised epidermal b

59 lid microneedles, providing microporation of stratum corneum and therefore enhancement of topical dru

60 normalities in both skin barrier structures (stratum corneum and tight junctions), a robust T(H)2 res

61 elivery system that can permeate through the stratum corneum and viable epidermis and efficiently dep

62 on, an accumulation of lipid droplets in the stratum corneum, and a water barrier defect.

63 ecreased intercellular lipid lamellae in the stratum corneum, and aberrant keratinocyte differentiati

64 f water ("cisternae") present throughout the stratum corneum, and at 24 h these cisternae substantial

65 wave emission, microjet penetration into the stratum corneum, and impact of microjet on the stratum c

66 otease activity, prevented detachment of the stratum corneum, and improved the barrier function of th

67 l epidermal changes, primarily involving the stratum corneum, and increased epidermal thickness were

68 on through the external barrier of the skin, stratum corneum, and secure exposure to the viable skin

69 ermal changes of the surrounding tissue, the stratum corneum; and information storage is possible in

70 ratum corneum, and impact of microjet on the stratum corneum are considered.

71 epidermis in Drosophila (cuticle) and mice (stratum corneum) are structurally unrelated.

72 within the polymer matrix, breach the skin's stratum corneum barrier and dissolve upon contact with s

73 e a proteolytic cascade that is required for stratum corneum barrier functionality.

74 on due to their ability to bypass the skin's stratum corneum barrier in a minimally-invasive fashion

75 ery to the skin is highly constrained by the stratum corneum barrier layer(1).

76 olgi network, that deliver the precursors of stratum corneum barrier lipids to the extracellular comp

77 o NIR dye and shown to penetrate through the stratum corneum barrier when topically applied to mouse

78 We show that on breakdown of the epidermal stratum corneum barrier, type 2 and type 17 inflammatory

79 rs, and differentiation to form an effective stratum corneum barrier.

80 work in mouse skin on breakdown of epidermal stratum corneum barrier.

81 rrier function is compromised because of the stratum corneum becoming spontaneously detached in the n

82 th a decrease in the free thiol layer in the stratum corneum, but not in the nucleated epidermis.

83 ular layer and thinning of the epidermis and stratum corneum by 50%.

84 ansverse diffusivities of these compounds in stratum corneum by factors ranging from 250 to over 2000

85 delivered to the extracellular spaces of the stratum corneum by the secretion of lamellar bodies.

86 Disruption of the stratum corneum, by acetone application on the skin of h

87 Physical disruption of the stratum corneum can improve the efficiency of delivery.

88 e sweat glands, since increased hydration in stratum corneum causes it to become softer.

89 of stratum corneum swelling, and identifies stratum corneum cell layers that swell less.

90 Both the number of stratum corneum cell layers was reduced and the processi

91 iciency caused striking malformations of the stratum corneum, characterized by dysmorphic and pleomor

92 In the normal epidermis, the stratum corneum chymotryptic enzyme (SCCE) thought to pl

93 ing enzymes are potential substrates for the stratum corneum chymotryptic enzyme (SCCE), protein extr

94 neum tryptic enzyme (SCTE, kallikrein 5) and stratum corneum chymotryptic protease (SCCE, kallikrein

95 ompromises permeability barrier homeostasis, stratum corneum cohesion, wound healing, and epidermal i

96 Ceramides in mammalian stratum corneum comprise a heterogeneous mixture of mole

97 Stratum corneum comprises corneocytes, derived from oute

98 f contact allergy, nickel sensitization, and stratum corneum defects.

99 involucrin) and prevented cytokine-mediated stratum corneum degradation.

100 hione and, following penetration through the stratum corneum, depleted thiols in the viable epidermis

101 ation, cornified envelope morphogenesis, and stratum corneum desquamation.

102 -related peptidases that are associated with stratum corneum detachment was either low or undetectabl

103 y and provides free amino acids in the outer stratum corneum, did not account for the relative humidi

104 confirmed that a well-tolerated regimen for stratum corneum disruption before vaccine patch applicat

105 e-induced immunity and that the magnitude of stratum corneum disruption correlates with the immune re

106 These rhythms persist during stratum corneum disruption with and without CS applicati

107 gic side-effects is related to the degree of stratum corneum disruption.

108 in desquamation by cleaving proteins of the stratum corneum (e.g., corneodesmosin and plakoglobin).

109 Injury to the stratum corneum elicits an epidermal hyperproliferative

110 assessed in culture media and extracts from stratum corneum, epidermis and dermis after 24h, and the

111 Even though stratum corneum exhibits structural features across mult

112 This concept is probed using excised human stratum corneum exposed to aqueous solutions of radiolab

113 define the in vivo swelling behavior of the stratum corneum: exposure to water for 4 or 24 h results

114 The stratum corneum extracellular matrix (ECM) is enriched i

115 n of the epidermis, including defects of the stratum corneum, extracellular lipid composition and cel

116 suggests that psoriasin, purified from human stratum corneum extracts, selectively kills Escherichia

117 maintain epidermal thickness, contributes to stratum corneum formation and may eliminate pre-malignan

118 ologic role in epidermal differentiation and stratum corneum formation in utero.

119 pidermis-specific polyprotein, profilaggrin, stratum corneum formation, and acquisition of epidermal

120 inocytes is required for epidermal turnover, stratum corneum formation, and removal of ultraviolet-da

121 encoding filaggrin, a protein essential for stratum corneum formation, these data point to an innate

122 Get-1(-/-) mice with striking impairment of stratum corneum formation.

123 inal differentiation protein expression, and stratum corneum formation.

124 Serum antibody reactive with human stratum corneum found in patients with psoriatic arthrit

125 f filaggrin were quantified in tape-stripped stratum corneum from 31 atopic dermatitis patients and u

126 mall numbers of bacteria which penetrate the stratum corneum from everyday activities.

127 f keratinocyte SerpinB2 is protection of the stratum corneum from proteolysis via inhibition of uroki

128 tratum corneum neutralization alone provokes stratum corneum functional abnormalities, including aber

129 lowing secretion of lamellar bodies into the stratum corneum, glucosylceramides are metabolized to ce

130 ix in the outer layer of mammalian skin, the stratum corneum, has been previously investigated by mul

131 t trypsin-like serine protease (TLSP) in the stratum corneum, have been implicated in the pathogenesi

132 tracellular metabolites, which contribute to stratum corneum hydration and pH.

133 We assessed here whether sebum influences stratum corneum hydration or permeability barrier functi

134 sters, triglycerides) did not restore normal stratum corneum hydration to asebia skin, topical glycer

135 on from triglyceride in sebaceous glands for stratum corneum hydration was demonstrated further by (i

136 e hydrolysis in sebaceous glands, normalized stratum corneum hydration, and the glycerol content of a

137 erplasia, inflammation, and decreased (>50%) stratum corneum hydration, associated with a reduction i

138 permeability barrier homeostasis and reduced stratum corneum hydration, we hypothesized here that epi

139 d-derived glycerol is a major contributor to stratum corneum hydration.

140 th ionic and uncharged, partition into human stratum corneum immersed in aqueous solutions to an exte

141 s that crisscross the cornified cells of the stratum corneum imparting structural integrity, and defe

142 by reduced glycerol content in epidermis and stratum corneum in AQP3-knockout mice, and correction of

143 pidermal water loss, increased overt loss of stratum corneum in inflammatory lesions, and impaired st

144 lasers) have been shown to permeabilize the stratum corneum in vivo and facilitate the transport of

145 oy, in contrast to BMV, restores compromised stratum corneum integrity and barrier function.

146 rmeability barrier homeostasis and decreased stratum corneum integrity/cohesion, as well as the mecha

147 cutaneous permeability barrier function and stratum corneum integrity/cohesion, as well as the respo

148 taneous permeability barrier homeostasis and stratum corneum integrity/cohesion, but these approaches

149 bnormalities in both barrier homeostasis and stratum corneum integrity/cohesion.

150 ase inhibitors with the superbase normalized stratum corneum integrity/cohesion.

151 Three modes of bubble-stratum corneum interactions including shock wave emissi

152 er exposure leads to extensive disruption of stratum corneum intercellular lipid lamellae.

153 he disruptive effect of overhydration on the stratum corneum intercellular space, identifies large an

154 ws a strong signal at the stratum granulosum/stratum corneum interface.

155 Keratinization of the stratum corneum involves a highly choreographed sequence

156 served after tape-stripping, indicating that stratum corneum is a major source of UVA-induced oxidati

157 The study suggests the stratum corneum is a more chaotic structure than previou

158 nderstanding of the mechanical properties of stratum corneum is based on the assumption that its thic

159 The stratum corneum is composed of protein-enriched corneocy

160 lux between the follicle and the surrounding stratum corneum is involved.

161 anisotropic brick-and-mortar geometry of the stratum corneum is obtained using the commercial finite

162 The barrier function of the stratum corneum is provided by patterned lipid lamellae

163 The permeabilization of the stratum corneum is transient and its barrier function re

164 The skin barrier (stratum corneum) is a major factor for determining the n

165 ed that the viable epidermis, underlying the stratum corneum, is included as a potentially important

166 brosidase activity at the stratum granulosum-stratum corneum junction and a modest decrease in both i

167 ence of expression at the stratum granulosum/stratum corneum junction.

168 ression of terminal differentiation markers (stratum corneum, K10, and loricrin).

169 The stratum corneum layer and Ki67 in keratinocytes of the e

170 xplain the lack of restoration of functional stratum corneum layers observed after BM treatment.

171 e expansion of the lacunar spaces within the stratum corneum leading to the formation of transient ch

172 trastructural analyses demonstrated abnormal stratum corneum lipid architecture in AD and IV HEEs, in

173 n expansion of the lacunar spaces within the stratum corneum lipid bilayers but no changes in the org

174 interactions of cavitation bubbles with the stratum corneum lipid bilayers.

175 oordinately drive both the generation of the stratum corneum lipid-enriched extracellular matrix and

176 aditional dermal absorption models treat the stratum corneum lipids as a homogenous medium through wh

177 d irregular distribution patterns within the stratum corneum lipids as observed in experimental data.

178 These studies demonstrate unequivocally that stratum corneum neutralization alone provokes stratum co

179 To study the consequences of stratum corneum neutralization, independent of hydration

180 The PCA content in the stratum corneum of AD(-)PA(+) subjects was significantly

181 ed changes in skin properties and CCBAs from stratum corneum of healthy human subjects, providing a m

182 c transport and distribution of water of the stratum corneum of infants and compare it to those of ad

183 The results suggest that although the stratum corneum of infants may appear intact shortly aft

184 Accordingly, the lipid composition of the stratum corneum of Irf6(-/-) skin was abnormal, culminat

185 The stratum corneum of lesional but also clinically unaffect

186 found in both interfollicular and follicular stratum corneum of lesional KP, which correlated ultrast

187 om the stratum basale, stratum spinosum, and stratum corneum of lesions from the transgenic mice usin

188 o compromised chelation of the metals in the stratum corneum of patients with atopic dermatitis.

189 n, higher protein-to-lipid ratios within the stratum corneum of RHS indicated reduced lipid amounts a

190 igo, Staphylococcus aureus spreads under the stratum corneum of skin by elaboration of exfoliative to

191 strated notable topographical changes in the stratum corneum of skin permeated with CYnLIP that were

192 laggrin is a major structural protein in the stratum corneum of the epidermis.

193 limited by their poor permeation across the stratum corneum of the skin and low penetration into the

194 y due to the transport barriers posed by the stratum corneum of the skin and the biofilm.

195 ic junctions made between the keratin of the stratum corneum of the skin and the glass surface.

196 The impact of the complex structure of the stratum corneum on transdermal penetration is not yet fu

197 evealed interactions between the gel and the stratum corneum or, more specifically, its protein and l

198 showed that it shrunk the corneocytes in the stratum corneum (p<0.001) and the imaging of the skin ha

199 ng the integrity and barrier function of the stratum corneum, particularly during times of skin infla

200 ed ductal penetration, but minimally altered stratum corneum penetration as compared to the control s

201 er breakdown, attributed to the elevation of stratum corneum pH.

202 The lipid matrix of the skin's stratum corneum plays a key role in the barrier function

203 tabolism or in the protein components of the stratum corneum produce scaly or ichthyotic skin with ab

204 In the stratum corneum proteases degrade the inhibitor, freeing

205 strated downregulation of tight junction and stratum corneum proteins in the skin of patients with se

206 cluding downregulation of tight junction and stratum corneum proteins, even in the absence of clinica

207 er hand, correlated with the denaturation of stratum corneum proteins, making it feasible to use prot

208 ) contains multiple conserved genes encoding stratum-corneum proteins.

209 any layers of these specialized cells in the stratum corneum provide a tough and resilient framework

210 Since stratum corneum (SC) acidification in adults is required

211 essential endogenous pathway responsible for stratum corneum (SC) acidification.

212 2-15 months) are linked instead to defective stratum corneum (SC) acidity.

213 Neutralization of stratum corneum (SC) adversely impacts key epidermal fun

214 s limited by their low absorption across the stratum corneum (SC) and into viable cells of skin.

215 e skin is often dependent upon breaching the stratum corneum (SC) and targeting cells within defined

216 Stratum corneum (SC) and viable epidermal thickness meas

217 rmal units has been proposed on the basis of stratum corneum (SC) architecture, proliferation kinetic

218 s of the long periodicity phase (LPP) in the stratum corneum (SC) are studied using bilayer-slab-bila

219 er abnormality was associated with decreased stratum corneum (SC) ceramide content and impaired lamel

220 At birth, human stratum corneum (SC) displays a near-neutral surface pH,

221 enotype, we assessed epidermal structure and stratum corneum (SC) function in a previously genotyped

222 e assessed the mechanisms by which PS alters stratum corneum (SC) function.

223 transporter aquaporin-3 (AQP3) have reduced stratum corneum (SC) hydration and skin elasticity, and

224 Although stratum corneum (SC) hydration has been primarily of con

225 Basal permeability barrier function and stratum corneum (SC) integrity were abnormal, but barrie

226 produces nonlamellar phase separation in the stratum corneum (SC) interstices, explaining the barrier

227 The stratum corneum (SC) is an effective permeability barrie

228 h quantity and spatial distribution of human stratum corneum (SC) lipids from samples collected in vi

229 Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) c

230 The reduced pH of the stratum corneum (SC) of darkly pigmented skin could acco

231 Abundant lacunae of unprocessed lipids in stratum corneum (SC) of FAK(K5 KO) mice and delayed barr

232 ges between altered ceramide profiles in the stratum corneum (SC) of patients with atopic dermatitis

233 showed recently that short-term increases in stratum corneum (SC) pH are accompanied by minor alterat

234 At birth, neonatal stratum corneum (SC) pH is close to neutral but acidifie

235 ifferences in epidermal function, we studied stratum corneum (SC) pH, permeability barrier homeostasi

236 alternative, but the barrier of skin's outer stratum corneum (SC) prevents delivery of most drugs.

237 ous abnormalities were not evident, and both stratum corneum (SC) skin hydration and surface pH were

238 We collected stratum corneum (SC) specimens from the volar forearms o

239 to puncture the skin, can bypass the skin's stratum corneum (SC) to enter the skin microcirculation

240 of skin's outermost and rate limiting layer stratum corneum (SC), and increase its permeability.

241 of the outermost layer of the epidermis, the stratum corneum (SC), are not understood.

242 izational details of epidermis, specifically stratum corneum (SC), during sonophoresis are beyond the

243 In neonatal rat stratum corneum (SC), pH declines from pH 6.8 at birth t

244 The outermost region of the epidermis, the stratum corneum (SC), provides an essential barrier to w

245 st versus fifth stripping ("outer" vs. "mid"-stratum corneum (SC), respectively) from nine normal adu

246 iscrete epidermal skin layers, including the stratum corneum (SC), stratum granulosum (SG), stratum b

247 Intercellular lipids of the stratum corneum (SC), the outer layer of the epidermis,

248 solvents on the outermost layer of skin, the stratum corneum (SC), using polarization transfer solid-

249 e goal of epidermal ontogenesis is to form a stratum corneum (SC), which is required for post-natal p

250 s (pH 5.0-5.5) over 5-6 days in neonatal rat stratum corneum (SC).

251 s through the skin, specifically through the stratum corneum (SC).

252 of the outermost layer of the epidermis, the stratum corneum (SC).

253 signaling from serine proteases (SP) in the stratum corneum (SC).

254 ve cutaneous functions largely reside in the stratum corneum (SC).

255 wed an abnormally-compacted outer epidermis [stratum corneum (SC)], while electron microscopy reveale

256 e outermost skin barrier (referred to as the stratum corneum, SC) and subsequent catalytic generation

257 The intercellular lipid matrix of the skin's stratum corneum serves to protect the body against desic

258 The stratum corneum showed parakeratotsis.

259 ation of the secreted lamellar bodies at the stratum corneum-stratum granulosum boundary.

260 he mechanical effects of these events on the stratum corneum structure, the relationship between the

261 including permeability barrier homeostasis, stratum corneum surface pH, and water-holding capacity,

262 crom) are acquired every 1.7 microm from the stratum corneum surface to the first viable layer (strat

263 sternal structures, defines the magnitude of stratum corneum swelling, and identifies stratum corneum

264 is to produce the protective, semi-permeable stratum corneum that permits terrestrial life.

265 ubstantially reduced drug diffusivity in the stratum corneum (the outermost epidermal layer), dominan

266 corresponding to a depth of 2-3 mum, of the stratum corneum (the outermost, 15-20 mum skin layer).

267 tion and allow S. aureus to spread under the stratum corneum, the main barrier of the skin, explainin

268 sed to effectively deliver siRNA through the stratum corneum, the major challenge is that this approa

269 Stratum corneum, the outermost layer of skin, allows tra

270 We study the drying of stratum corneum, the skin's outermost layer and an essen

271 Retinoids cause dyshesion and thinning of stratum corneum, thereby reducing hyperkeratosis that li

272 orneum in inflammatory lesions, and impaired stratum corneum thickening after phorbol ester treatment

273 markers (filaggrin and loricrin), increased stratum corneum thickness, and significantly reduced T-c

274 h results in a 3- or 4-fold expansion of the stratum corneum thickness, respectively.

275 es had larger values consistently for infant stratum corneum throughout the first year of life and sh

276 ations, reacts with amino acids in the outer stratum corneum to form a mixture of high molecular weig

277 Both exposure of stratum corneum to neutral pH buffers and blockade of ac

278 inished cholesterol sulfate signal along the stratum corneum toward the migrating epithelial tongue.

279 g abnormality associated with an increase in stratum corneum tryptic enzyme (SCTE) in the epidermis.

280 estern blot, and siRNA, the serine proteases stratum corneum tryptic enzyme (SCTE, kallikrein 5) and

281 Located in the stratum corneum, urocanic acid is a major epidermal chro

282 get their effects to skin's barrier layer of stratum corneum using microneedles, thermal ablation, mi

283 ydration, and the glycerol content of asebia stratum corneum was 85% lower than in normal stratum cor

284 The interaction of water with the stratum corneum was assessed by measuring capacitance, t

285 The skin barrier was defective and the stratum corneum was detached through desmosomal cleavage

286 In the current study, the stratum corneum was disrupted using an electrocardiogram

287 glyceride content of both asebia and control stratum corneum was low, consistent with high rates of t

288 dities, indicating that the structure of the stratum corneum was not a major factor.

289 AQP3-knockout mice have reduced stratum corneum water content and elasticity compared wi

290 on found in the extracellular matrix of skin stratum corneum, were analyzed by X-ray diffraction meth

291 Unlike stratum corneum where lipids are organized under a preci

292 tioning-limited solute diffusion through the stratum corneum, where the lipid structure is represente

293 epidermal epithelium leading to a defective stratum corneum, which allows enhanced allergen penetrat

294 ifferentiation and the formation of a mature stratum corneum, which is essential for the skin to prev

295 s vaccination is the barrier function of the stratum corneum, which must be overcome either by abrasi

296 uantity of ultra long-chain ceramides in the stratum corneum, which play a key role in maintaining th

297 kin revealed hyperkeratosis and a disordered stratum corneum with an accumulation of neutral lipid dr

298 se from a pathogen that is restricted to the stratum corneum, with little or no tissue reaction.

299 paired skin barrier function and a defective stratum corneum, with SerpinB2(-/-) mice showing increas

300 pended in water, facilitate adherence to the stratum corneum without subsequent intra-epidermal or fo