ライフサイエンスコーパス: streptococcal

1 Here we show that streptococcal 4-aminobenzoate/para-amino benzoic acid (p

2 . pyogenes virulence factor, which we termed streptococcal 5'-nucleotidase A (S5nA).

3 y, this priming step appears to be unique to streptococcal ABC transporter-dependent RhaPS biosynthes

4 donii and in Escherichia coli expressing the streptococcal accessory Sec system.

5 standing of the predominant features of oral streptococcal adaptive immune repertoires.

6 he beta-sandwich domain seen in the parental streptococcal adhesin, but flanking sequences at both N-

7 otein Epf from S. pyogenes serotype M49 is a streptococcal adhesin.

8 sin, Fap1, demonstrating that BapA1 is a new streptococcal adhesin.

9 cosylation of a family of serine-rich repeat streptococcal adhesins.

10 a mutant deficient in the production of the streptococcal ADP-ribosyltransferase SpyA generates lesi

11 retention, we tested the effect of adding a streptococcal albumin-binding domain (ABD) and a llama s

12 Although streptococcal and Bacillus UGLs were active on unsaturat

13 In comparison with structures of streptococcal and Bacillus UGLs, a pocket-like structure

14 SC-derived mAb 24.3.1 was found to recognize streptococcal and brain Ags.

15 -rhamnose biosynthesis, such as Ri03, affect streptococcal and mycobacterial viability and can serve

16 biotic used as the last resort treatment for streptococcal and staphylococcal bacteria including meth

17 soriasis activity has been linked to group A streptococcal and viral infections.

18 llin-resistant Staphylococcus aureus (MRSA), streptococcal, and pneumococcal bacteremia were found to

19 It was seen more commonly with MRSA, streptococcal, and pneumococcal species.

20 Affinity purification of the anti-streptococcal antibodies present within pooled immunoglo

21 The streptococcal antigen I/II (AgI/II)-family polypeptides

22 ion of the minor fimbrial antigen (Mfa) with streptococcal antigen I/II (e.g., SspB) facilitates colo

23 algorithms used a rapid and specific group A streptococcal antigen test to screen throat specimens, f

24 erful lysin with potential for treating most streptococcal associated infections.

25 IgG from SC and a related subset of streptococcal-associated behavioral disorders called "pe

26 Streptococcal attachment to and entry into epithelial ce

27 The theme of molecular mimicry in streptococcal autoimmune sequelae is the recognition of

28 pathogenesis of rheumatic fever and group A streptococcal autoimmune sequelae of the heart valve and

29 AE reports for viridans group streptococcal bacteremia, a targeted toxicity on AAML053

30 he third Ig-binding domain of protein G from streptococcal bacteria (GB3).

31 Streptococcal bacteria use peptide signals as a means of

32 colonized much less efficiently in vitro on streptococcal biofilms than on Actinomyces naeslundii bi

33 latelets directly enhances the resistance of streptococcal biofilms to clindamycin.

34 lonization of S. mutans BM71 on the existing streptococcal biofilms.

35 ght the potential importance of prophages in streptococcal biology and pathogenesis.

36 ults of routine throat cultures on selective streptococcal blood agar plates.

37 We analyzed 58 recent oral streptococcal bloodstream isolates, and we obtained clin

38 Among 6506 cases with streptococcal BSIs (mean age 68.1 years [SD 16.2], 52.8%

39 The prevalence of IE in streptococcal BSIs is species dependent with S mutans, S

40 We investigated all patients with streptococcal BSIs, from 2008 to 2017, in the Capital Re

41 ence of IE at species level in patients with streptococcal BSIs.

42 wo conserved group A streptococci (GAS) Ags, streptococcal C5a peptidase and immunogenic secreted pro

43 biosynthesis, whereas the Wzx/Wzy-dependent streptococcal capsular polysaccharide pathways instead r

44 Autoantibodies against the group A streptococcal carbohydrate epitope GlcNAc and cardiac my

45 GAS-induced IL-17A significantly influences streptococcal carriage and alters local inflammatory res

46 n (Plg)-binding M protein (PAM) is a group A streptococcal cell surface receptor that is crucial for

47 ent serotypes of the coaggregation-mediating streptococcal cell-surface receptor polysaccharides (RPS

48 The competitiveness of low-passage commensal streptococcal clinical isolates is positively influenced

49 oinflammation associated with an established streptococcal CNS infection when delivered therapeutical

50 utbreak investigation implicated measles and streptococcal co-infections in most deaths, and also cha

51 The streptococcal collagen-like (Scl) proteins are widely pr

52 ce factors deployed by streptococci includes streptococcal collagen-like (Scl) proteins.

53 Streptococcal collagen-like protein 1 (Scl-1) is one of

54 The streptococcal collagen-like protein 1 (Scl1) is a major

55 urring polymorphism in the gene encoding the streptococcal collagen-like protein A (SclA) in GAS carr

56 We recently reported that the streptococcal collagen-like protein-1, Scl1, selectively

57 ot affect triple helix stability of the Scl (Streptococcal collagen-like) protein.

58 Prior treatment with estradiol prolonged streptococcal colonization and was associated with reduc

59 asal vaccine are necessary for prevention of streptococcal colonization.

60 S. bovis groups of species, even though many streptococcal competence genes and the competence regula

61 f pneumococcus can replace its cps with oral streptococcal cps, it may increase its serotype repertoi

62 their viruses in humans, we analysed 13 977 streptococcal CRISPR sequences and compared them with 2

63 oexist at the same time, which suggests that streptococcal CRISPR/Cas systems are under constant pres

64 combining J8-DT with an inactive form of the streptococcal CXC protease, S. pyogenes cell envelope pr

65 lic replacement of the chromosomally encoded streptococcal cysteine protease (speB) in the MGAS5005 D

66 Streptococcal cysteine protease (SpeB), the major secret

67 Expression of SpeB, a streptococcal cysteine protease, is critical for this pr

68 Viridans group streptococcal detection using PHIS microbiology data had

69 The streptococcal determinant camG encodes a lipoprotein wit

70 Early-onset group B streptococcal disease (EOGBS) occurs in neonates (days 0

71 en and clinical features of invasive group B streptococcal disease in infants younger than 90 days in

72 ve national surveillance of invasive group B streptococcal disease in infants younger than 90 days wa

73 The incidence of invasive infant group B streptococcal disease in the UK and Ireland has increase

74 babies younger than 7 days) invasive group B streptococcal disease is rectovaginal colonisation of th

75 ibitors to be used in prevention of invasive streptococcal disease.

76 I, III, V) could prevent most global group B streptococcal disease.

77 (day 0-6) and late-onset (day 7-89) group B streptococcal disease.

78 ethod facilitating the prevention of group B streptococcal disease.

79 induce complete protection against invasive streptococcal disease.

80 ing an extracellular DNase virulence factor (streptococcal DNase D2, SdaD2) and subsequently acquired

81 The incidence of oral streptococcal endocarditis did not increase (unadjusted:

82 heavy-chain glycan on asparagine 297 by the streptococcal enzyme endo-beta-N-acetylglucosaminidase (

83 ronal cell in Sydenham chorea share a common streptococcal epitope GlcNAc and target intracellular bi

84 oantibodies that target the dominant group A streptococcal epitope of the group A carbohydrate, N-ace

85 expression of the CovRS-controlled secreted streptococcal esterase (SsE).

86 A") protects mice from lethal challenge with streptococcal exotoxin A, as well as from lethal GAS bac

87 We named this protease SepM for streptococcal extracellular protease required for mutaci

88 esults of this study reveal a novel secreted streptococcal factor that, in the absence of SpeB, can t

89 vasive disease have been described, specific streptococcal factors and host properties influencing as

90 tify a putative fibronectin binding protein, streptococcal fibronectin binding protein A (SfbA).

91 To explore the level and extent of streptococcal fomite contamination that children might b

92 Group A streptococcal (GAS) infection induces the production of

93 AIP) began surveillance for invasive group A streptococcal (GAS) infections in Alaska in 2000 as part

94 s (NSAIDs) contribute to more severe group A streptococcal (GAS) infections, yet a beneficial role fo

95 endations regarding the diagnosis of group A streptococcal (GAS) pharyngitis in adults.

96 Group A streptococcal (GAS) pharyngitis is a particularly import

97 g or treating adults at low risk for group A streptococcal (GAS) pharyngitis.

98 Invasive group A streptococcal (GAS) strains often have genetic differenc

99 on of streptokinase (SK), a critical group A streptococcal (GAS) virulence factor, were identified th

100 Survivors of infant group B streptococcal (GBS) disease are at risk of neurodevelopm

101 Further reduction in the group B streptococcal (GBS) disease burden in neonates in the Un

102 rain to injury; however, the role of group B streptococcal (GBS) disease has not been reviewed.

103 amining the epidemiology of invasive group B streptococcal (GBS) disease have been undertaken.

104 eighth in a series on the burden of group B streptococcal (GBS) disease, aims to estimate the percen

105 axis (IAP) prevents most early-onset group B streptococcal (GBS) disease.

106 model studies have demonstrated less group B streptococcal (GBS) invasive disease and gastrointestina

107 All streptococcal genomes encode the alternative sigma facto

108 For over a century, acute 'post-streptococcal glomerulonephritis' (APSGN) was the protot

109 des, which are mostly glucans synthesized by streptococcal glucosyltransferases (Gtfs), provide bindi

110 cation schemes within members of the "mitis" streptococcal group.

111 otential mechanism to bolster oral commensal streptococcal H(2)O(2) production by magnesium (Mg(2+))

112 reptococcus gordonii as a model organism for streptococcal H(2)O(2) production, H(2)O(2)-dependent eD

113 to play a role limited to the penetration of streptococcal HA capsules, facilitating bacterial lysoge

114 As determined by apo Streptococcal haem-associated protein, Hb had the lower

115 We evaluate the streptococcal hemoprotein receptor (Shr), a conserved st

116 -rich glycoprotein (HRG), and the name sHIP (streptococcal histidine-rich glycoprotein-interacting pr

117 hese results, plus the suspected role of the streptococcal homologue in certain diseases such as acut

118 ith robust activity and an extended-spectrum streptococcal host range against most streptococcal spec

119 een mitral valve prolapse and viridans group streptococcal IE in a population-based cohort from Olmst

120 sociated with an increased incidence of oral streptococcal IE.

121 Thus, tissue deposition of streptococcal IgA-binding M proteins may contribute to t

122 ulin (IVIG) in treatment of invasive group A streptococcal (iGAS) infection, and the need for prophyl

123 rotease distinct from previous characterized streptococcal immunoglobulin degrading proteases of the

124 and is the main neurologic manifestation of streptococcal-induced rheumatic fever.

125 9.4 million), rheumatic heart disease due to streptococcal infection (9.4 million), and cervical canc

126 e neuropsychiatric disorders associated with streptococcal infection (PANDAS).

127 Streptococcal infection has been linked with the develop

128 de driving IFN-beta in macrophages (MPhi) in streptococcal infection is the cGAS-STING pathway, where

129 t disease (RHD) is a complication of group A streptococcal infection that results from a complex inte

130 tic shock; for 16 (50%) women with a group A streptococcal infection there was <2 h-and for 24 (75%)

131 icularly with confirmed or suspected group A streptococcal infection, should be regarded as an obstet

132 During group B streptococcal infection, the alpha C protein (ACP) on th

133 lines focus solely on group A beta-hemolytic streptococcal infection.

134 such as rheumatic heart disease and invasive streptococcal infection.

135 ion of bacterial adaptations during systemic streptococcal infection.

136 of CpsY-dependent regulation during systemic streptococcal infection.

137 ppressed transcription of these genes during streptococcal infection.

138 ate of varicella-associated invasive group A streptococcal infections (IGASI).

139 ted with increased risks, although less than streptococcal infections for OCD and any mental disorder

140 0.3% and 26.4% of all IE, with a decrease in streptococcal infections over time.

141 H binding in vivo (i.e., for pathogenesis of streptococcal infections), we used our recent finding th

142 e neuropsychiatric disorders associated with streptococcal infections, or PANDAS, describes such a si

143 describe a mechanism that underpins epidemic streptococcal infections, which have affected many milli

144 ay improve outcomes in patients with serious streptococcal infections.

145 s M protein (emm), C5a peptidase (scpA), and streptococcal inhibitor of complement (sic) by directly

146 ovides a novel biophysical aspect of Candida-streptococcal interaction whereby extracellular glucans

147 ture design of small molecular inhibitors of streptococcal invasion.

148 A total of 155 nonduplicate streptococcal isolates (50 group A, 48 group B, 28 group

149 Fifty-six alpha-hemolytic streptococcal isolates were identified using MALDI Bioty

150 ructure revealed a strong resemblance to the streptococcal laminin-binding proteins Lbp and Lmb.

151 SPy_2191 immunization significantly reduces streptococcal load in the organs and confers ~76-92% pro

152 ionships between plasminogen-binding group A streptococcal M (PAM) protein and SK2b have been reveale

153 en (Pg)/plasmin receptor, Pg-binding group A streptococcal M protein (PAM), and the human Pg activato

154 d the presence of T cells crossreactive with streptococcal M protein and cardiac myosin.

155 The streptococcal M protein that is used as the substrate fo

156 that respond to peptide sequences common to streptococcal M proteins and skin keratins have been det

157 previously shown that IgA-binding regions of streptococcal M proteins colocalize with IgA in mesangia

158 rldwide, regardless of the infecting group A streptococcal M serotype.

159 due internal peptide (VEK-30) from a group A streptococcal M-like protein, the dynamic properties of

160 plasminogen (human Pg (hPg)) binding Group A streptococcal M-protein (PAM) as its major cell surface

161 urface receptor, plasminogen-binding group A streptococcal M-protein (PAM).

162 cal properties of the complex formed between streptococcal M1 and human fibrinogen.

163 e structure and biosynthesis of streptide, a streptococcal macrocyclic peptide.

164 ortant mechanistic implications for the anti-streptococcal macrophage response and sepsis pathogenesi

165 ed membrane protein which is anchored to the streptococcal membrane by an N-terminal transmembrane se

166 with peptide affinity tags is located in the streptococcal membrane.

167 with BBB endothelium and the pathogenesis of streptococcal meningitis.

168 lood-brain barrier and in the development of streptococcal meningitis.

169 ioning to favour carbon sources generated by streptococcal metabolism.

170 for IL-17A in contributing to the control of streptococcal mucosal colonization and provide new insig

171 mparable to those for the well-characterized streptococcal natural transformation systems.

172 not present in the previously characterized streptococcal OatA.

173 coli strains through induction of different Streptococcal (p)ppGpp synthetase fragments.

174 eals the potential of PCR/ESI-MS to detect a streptococcal pathogen not captured by conventional cult

175 tools for the understanding of Scl-mediated streptococcal pathogenesis and important structural insi

176 We conclude that SpyA contributes to streptococcal pathogenesis in the mouse subcutaneous inf

177 This work provides new perspectives in streptococcal pathogenesis with implications for immunit

178 prompt a reevaluation of the role of SPN in streptococcal pathogenesis.

179 ited growth of GAS, other rhamnose-dependent streptococcal pathogens as well as M. tuberculosis with

180 Streptococcal pathogens have evolved to express exoglyco

181 Many streptococcal pathogens require a polysaccharide capsule

182 Streptococcal pathogens require dTDP-L-rhamnose for the

183 own as pili, have been recently described in streptococcal pathogens, including GBS.

184 Streptococcal pathogens, such as the group B streptococc

185 d in stools was highly suggestive of group A streptococcal perianal infection (probability 83.3%).

186 patients with symptoms suggestive of group A streptococcal pharyngitis (for example, persistent fever

187 uncommon at baseline and changed little for streptococcal pharyngitis (intervention, from 4.4% to 3.

188 acute enteritis, 9; Helicobacter pylori, 1; Streptococcal pharyngitis 1; and posttransplant lymphoma

189 any causes of pediatric pharyngitis, group A streptococcal pharyngitis represents 15 to 30% of infect

190 Little is known why streptococcal pharyngitis usually does not lead to pneum

191 icient for the accurate diagnosis of group A streptococcal pharyngitis, and laboratory testing for co

192 es current point-of-care testing for group A streptococcal pharyngitis, including rapid antigen detec

193 with antibiotics only if they have confirmed streptococcal pharyngitis.

194 um-positive pharyngitis clinically resembles streptococcal pharyngitis.

195 or adult and pediatric patients with group A streptococcal pharyngitis.

196 19179 with acute otitis media; 6746, group A streptococcal pharyngitis; and 4234, acute sinusitis), 4

197 (1100 with acute otitis media; 705, group A streptococcal pharyngitis; and 667, acute sinusitis), 86

198 The type PI-1 streptococcal pilus is a complex, well studied structure

199 ment of Cpa to target receptors and thus the streptococcal pilus to host cells.

200 is is the largest series to our knowledge of streptococcal PJI managed by DAIR, showing a worse progn

201 Eligible patients had a streptococcal PJI that was managed with DAIR.

202 characterised a parallel epidemic of primary streptococcal pneumonia in soldiers without measles.

203 cial for the prevention of diseases, such as streptococcal pneumonia, that are devastating in older p

204 derations when choosing a method for group A streptococcal point-of-care testing, implementation of m

205 nthesized by conjugation of type III group B streptococcal polysaccharide (GBSIII) to ovalbumin (OVA)

206 le to locus diversification or to changes in streptococcal population structure, yet the composition

207 more frequently than group A beta-hemolytic streptococcal-positive pharyngitis in a student populati

208 ings on the immunoglobulin-binding domain of streptococcal protein G (GB1), these experimental result

209 ed using the albumin-binding domain (ABD) of streptococcal protein G as a stable protein scaffold.

210 gment crystallizable (Fc) binding domains of streptococcal protein G to a linear polymer.

211 rived from Albumin Binding Domain (ABDwt) of streptococcal protein G, so called REX and ARS ligands w

212 t of the immunoglobulin binding domain B1 of streptococcal protein G, which in its native conformatio

213 Monte-Carlo rates for the well-characterized Streptococcal protein G.

214 ccal hemoprotein receptor (Shr), a conserved streptococcal protein, as a vaccine candidate against GA

215 ected transcript levels of the gene encoding streptococcal proteinase B, a major RopB-regulated virul

216 These streptococcal proteins form a structurally distinct subc

217 ng mechanism of BBK32 and previously studied streptococcal proteins suggests that the binding and ass

218 that CP outcompetes staphylococcal MntC and streptococcal PsaA for Mn(II).

219 a proteinaceous type II TA cassette from the streptococcal pSM19035 plasmid is a member of the epsilo

220 mmunization against the Vbeta8-targeting SAg streptococcal pyrogenic exotoxin A (SpeA), or active imm

221 Transcript and protein expression of streptococcal pyrogenic exotoxin A (SpeA; also known as

222 the phage encoding the SpeA1 variant of the streptococcal pyrogenic exotoxin A superantigen.

223 A secreted cysteine protease known as streptococcal pyrogenic exotoxin B (SpeB) is a key virul

224 Streptococcal pyrogenic exotoxin B (SpeB) is a protease

225 Streptococcal pyrogenic exotoxin B (SpeB) is an extracel

226 on expression of the extracellular protease, streptococcal pyrogenic exotoxin B (SpeB), capsular hyal

227 s encoding streptococcal superantigen (ssa), streptococcal pyrogenic exotoxins (speC, speH, and speI)

228 equently, we determined that pneumolysin and streptococcal pyruvate oxidase-derived H2O2 production w

229 We found a high sensitivity of a group A streptococcal rapid diagnostic testing (98%) but relativ

230 We conclude that VP1 is a novel streptococcal regulatory peptide that controls biofilm d

231 analyzed CRISPR sequences with corresponding streptococcal repeats in order to improve our understand

232 urrent work, we target a widespread group of streptococcal RiPP BGCs and elucidate both the reaction

233 Although streptococcal SAgs are known virulence factors in scarle

234 oid cells, has to be adapted with respect to streptococcal sensing, handling, and response.

235 e of HLA-II allelic variations in modulating streptococcal sepsis outcomes and suggest the presence o

236 el mechanism of complement activation during streptococcal sepsis, which contributes to the platelet

237 obulin-like lectins (Siglec)-like domains of streptococcal serine-rich repeat (SRR) adhesins recogniz

238 ibbling mechanism that is similar to that of streptococcal serum opacity factor, which also selective

239 ein that may function as a type of conserved streptococcal shape, elongation, division, and sporulati

240 the genomes of strains causing pharyngitis (streptococcal "sore throat").

241 Staphylococcus aureus and streptococcal species accounted for 30.3% and 26.4% of a

242 we investigated the risk of IE according to streptococcal species adjusted for age, sex, >=3 positiv

243 lymers, including capsular polysaccharide of streptococcal species and arabinogalactan of mycobacteri

244 nsporter complex in four different sensitive streptococcal species and demonstrated that it can confe

245 ore, we draw parallels with other pathogenic streptococcal species and provide future research perspe

246 lutionary relic that is not utilized in this streptococcal species and, as such, is under no selectio

247 All streptococcal species contain the master regulator SigX

248 ral genetic transformation; however, not all streptococcal species have been shown to be naturally co

249 stream infections (BSIs) caused by different streptococcal species is unknown.

250 voir for many potential pathogens, including streptococcal species that cause endocarditis.

251 ectrum streptococcal host range against most streptococcal species, including S. pyogenes, S. agalact

252 ial sex pheromone system in a commensal oral streptococcal species, which may have implications for i

253 ve, the most common being Staphylococcal and Streptococcal species.

254 nents (PlyCA and PlyCB) that is specific for streptococcal species.

255 shing between atypical pneumococci and other streptococcal species.

256 ) were identified in four different pyogenic streptococcal species.

257 ration of natural transformation in multiple streptococcal species.

258 lved in phage replication in this food-grade streptococcal species.

259 in vitro phenotypes of its homologs in other streptococcal species.

260 We show that an oral streptococcal strain, SK95, and a pneumococcal strain, D

261 Genome sequencing of an additional 1,125 streptococcal strains and virulence studies revealed tha

262 caused by multidrug-resistant neisserial or streptococcal strains.

263 The streptococcal studies showed much higher MIC/MBC results

264 e oxidative stress-adaptive responses by the streptococcal subfamily of PerR.

265 ND.1 to PhiM23ND.4, harboring genes encoding streptococcal superantigen (ssa), streptococcal pyrogeni

266 ndrome (TSS) is caused by staphylococcal and streptococcal superantigens (SAgs) that provoke a swift

267 eptococcus sepsis by modulating responses to streptococcal superantigens (Strep-SAgs).

268 o yield plasma-neutralizing activity against streptococcal superantigens.

269 Here we show that the streptococcal surface protein SfbI mediates covalent int

270 In particular, streptococcal surface proteins have been implicated as p

271 Isolation of the streptococcal surface proteins recognised by pooled huma

272 by virtue of repetitive sequences-designated streptococcal surface repeats.

273 Individuals with a positive streptococcal test result had an increased risk of any m

274 21 girls and 547922 boys), 638265 received a streptococcal test, 349982 of whom had positive test res

275 < .001), compared with individuals without a streptococcal test.

276 on on individuals with the registration of a streptococcal test.

277 testing, implementation of molecular group A streptococcal testing, and the institutional cost of imm

278 cebo arm due to ineligibility arising from a streptococcal throat infection and one in the lumacaftor

279 DAS hypothesis found that individuals with a streptococcal throat infection had elevated risks of men

280 l disorder and OCD was more elevated after a streptococcal throat infection than after a nonstreptoco

281 specifically OCD and tic disorders, after a streptococcal throat infection.

282 type of psoriasis is usually associated with streptococcal throat infections and mainly occurs in HLA

283 of chronic psoriasis can be associated with streptococcal throat infections, and T cells that respon

284 ith protection from erysipelas (n = 278) and streptococcal tonsillitis (n = 209) compared with contro

285 from patients with flares associated with a streptococcal tonsillitis and with the HLA-Cw6 allele (c

286 Streptococcal toxic shock syndrome (STSS) and necrotizin

287 Streptococcal toxic shock syndrome (STSS) is a rapidly p

288 a patient with necrotizing fasciitis (NF) or streptococcal toxic shock syndrome (STSS).

289 severe invasive disease in humans, including streptococcal toxic shock syndrome and necrotizing fasci

290 Eighty-four cases of severe iGAS infection (streptococcal toxic shock syndrome, necrotizing fasciiti

291 nd in patients with necrotizing fasciitis or streptococcal toxic shock syndrome.

292 up for the outcomes of death, limb loss, and streptococcal toxic shock syndrome.

293 t case of S. suis arthroplasty infection and streptococcal toxic shock-like syndrome due to an nonenc

294 sults have bearing on the pathophysiology of streptococcal toxic shock.

295 e strand) in the S. suis 05ZYH33 that causes streptococcal toxin shock-like syndrome.

296 ted upon endolysosomal processing of group B streptococcal type III polysaccharide coupled to a carri

297 an impaired antibody response against a key streptococcal virulence factor.

298 We identify streptococcal virulence mechanisms important for bacteri

299 ign of future studies of M protein function, streptococcal virulence, epidemiological surveillance, a

300 a vaccine target and a major determinant of streptococcal virulence.