ライフサイエンスコーパス: stress

1 ing the Hippo pathway in response to osmotic stress.

2 n attenuated unfolded protein response to ER stress.

3 equent cold acclimation followed by freezing stress.

4 ctrin tetramers to release excess mechanical stress.

5 nd absorption and does not generate cellular stress.

6 use of hyperglycemia and resultant oxidative stress.

7 I, suggesting improvement in myocardial wall stress.

8 s mediates neuronal injury through oxidative stress.

9 SAA2 production in Th17-deficient mice after stress.

10 d nutrient uptake, and lowering in oxidative stress.

11 ding intracellular infection and proteotoxic stress.

12 to the pathophysiology that follows chronic stress.

13 d spontaneously recover after removal of the stress.

14 d promotes cellular survival during times of stress.

15 Germ cells are vulnerable to stress.

16 ctivator of PKM2, during acute outer retinal stress.

17 that FACT is needed to overcome replication stress.

18 ue to TEPP-46-induced increases in oxidative stress.

19 em more susceptible to ROS-induced oxidative stress.

20 pathway and increased endothelial oxidative stress.

21 ed RNA during several forms of environmental stress.

22 hase cell death during exposure to weak acid stress.

23 space for potential pathogens during thermal stress.

24 to individual differences in the response to stress.

25 ased in autumn due mainly to increased water stress.

26 sucrose preference after subchronic variable stress.

27 ing contractility reserve after hypertrophic stress.

28 metal-based anticancer agents that cause ER stress.

29 ak (DSB) repair and in resolving replication stress.

30 , to study their vulnerability to flow shear stress.

31 herb capable of performing CAM under drought stress.

32 l Ca(2+) overload during periods of nutrient stress.

33 taining systemic homeostasis under metabolic stress.

34 ng ribosome biogenesis and repress nucleolar stress.

35 d anticipated resource demands, and personal stress.

36 evaporative cooling that mitigates crop heat stress.

37 bind to this protein during nonreductive ER stress.

38 thesis during cellular response to oxidative stress.

39 h inhibition and hypersensitivity to osmotic stress.

40 ajor mechanisms it uses to recover from this stress.

41 individual mice may be experiencing thermal stress.

42 c stage as host cells become physiologically stressed.

43 ular deformation at moderate-to-higher shear stresses.

44 acid-a plant hormone associated with abiotic stresses.

45 In the CNS, early-life stress (1) decreased 2-arachidonoyl glycerol and arachid

46 often referred to a second noninvasive test (stress: 14.6% versus 8.5%, odds ratio [OR], 1.91; CTA: 3

47 ee acute (24 h) temperature treatments: cold stress (18 degrees C), heat stress (32 degrees C), or a

48 mes were higher for both inconclusive tests (stress: 3.7% versus 2.0%, hazard ratio, 1.81, P=0.034; C

49 treatments: cold stress (18 degrees C), heat stress (32 degrees C), or a control (24 degrees C).

50 ographics; (2) social network; (3) perceived stress; (4) consideration of future consequences; (5) gl

51 .4%, OR, 5.95; P<0.001) and catheterization (stress: 5.5% versus 2.4%, OR, 2.36; CTA: 23.4% versus 4.

52 erall, 8.0% of tests were inconclusive (9.7% stress, 6.4% CTA).

53 rd ratio, 1.85; P=0.044) and positive tests (stress: 8.3% versus 2.0%, hazard ratio, 3.50; CTA: 9.2%

54 ce that have undergone chronic social defeat stress, a mouse model of depression, at both the level o

55 Here, we utilized single prolonged stress, a validated rodent model of post-traumatic stres

56 esangial cells dividing during hyperglycemic stress abnormally synthesize hyaluronan (HA) in intracel

57 xercise and temperature-matched passive heat stress ABSTRACT: Acute moderate-intensity exercise incre

58 lated SMAD1/5 acts in synergy with metabolic stress-activated FOXO1 through formation of a complex.

59 ng and interpreting the roles of proteins in stress-activated signaling networks.

60 in regulating plant growth, development and stress adaptations.

61 s success to date in targeting stressors and stress allostasis in treatments for SUDs.

62 ulated glycolysis markedly induced metabolic stress, along with AMPK activation and mTORC1 pathway su

63 Chronic social stress alters blood-brain barrier (BBB) integrity throug

64 in other organisms, sHSPs are upregulated by stress and are proposed to act as molecular chaperones t

65 The homeostatic link between oxidative stress and autophagy plays an important role in cellular

66 siRNA mitigated radiation-induced oxidative stress and cellular injury.

67 Importantly, H. pylori-induced replication stress and DNA damage depend on the presence of co-trans

68 l states promotes cancer cell survival under stress and fosters non-genetic heterogeneity (NGH).

69 It forms fibrils both under cellular stress and in mutated form in neurodegenerative conditio

70 ) Cellular signaling changes; (iv) Oxidative stress and inflammatory responses.

71 oacervating with RNA in the cytoplasm during stress and may be involved in these pathologies.

72 us to how Escherichia coli encountering cell stress and nutrient deprivation can up-regulate and acti

73 pregulated pathways dominated by ATF4-driven stress and proapoptotic responses.

74 is an important brain region that processes stress and regulates immune and autonomic functions.

75 t1), that mimics tassel blasting and drought stress and reveals the genetic mechanisms underlying the

76 he variation of this clade, secondly, relate stress and shape variables, and finally, to classify fos

77 tress, uncovering an unexpected link between stress and sister chromatid cohesion loss.

78 Exposure to traffic noise is associated with stress and sleep disturbances.

79 lane polarization under external compressive stress and spontaneously recover after removal of the st

80 mise the ability of pathogens to resist HOCl stress and therefore may increase the efficacy of the in

81 rioventricular groove, which worsened during stress and were related to malformation severity.(C) RSN

82 rom pathogens, promotes tolerance to abiotic stresses and fortifies cells to withstand the forces ass

83 tissue repair enzymes, pathways of oxidative stress, and altered intestinal barrier function.

84 shaped by diversifying selection on drought stress, and can inform genomics-enabled breeding for cli

85 tasis requires a dynamic response of HSCs to stress, and dysregulation of these adaptive-response mec

86 trient starvation, proteotoxic and organelle stress, and elevation of reactive oxygen species (ROS).

87 healthy diet, lack of exercise, psychosocial stress, and insufficient sleep are increasingly prevalen

88 ty, household economic disruption, household stress, and interruptions in healthcare will contribute

89 mechanical stimuli including stretch, shear stress, and osmotic pressure.

90 Also, they reduced weight loss, oxidative stress, and the anthracnose (Colletotrichum gloeosporioi

91 tion in these mosquitoes is regulated by the stress- and immune-responsive c-Jun N-terminal kinase (J

92 able therapeutic target for individuals with stress- and trauma-related disorders.SIGNIFICANCE STATEM

93 ltwater today are resilient to hydrofracture-stresses are low enough that all water-filled fractures

94 Nervous system development" and "Response to Stress" as the top significantly different biological pr

95 Notably, short-term acute heat stress assays resolved per-colony (genotype) differences

96 ative capacity may protect against oxidative stress associated with birth while ensuring energy avail

97 that an insulin sensitizer may alleviate ER stress associated with YIPF5 disruption by decreasing th

98 ral hypothalamus (LH)] mediates avoidance of stress-associated stimuli.

99 rodes and a strain sensor that eliminate the stress at the interface between the electronics and grow

100 behavioral responses, mostly related to the stress axis.

101 led 40-300 nm diameter OMVs from control and stressed biofilm cells.

102 sess ribosomal integrity following oxidative stress both in vitro and in cells to elucidate details o

103 disulfide bond formation during reductive ER stress but did not bind to this protein during nonreduct

104 gically associated with significant cellular stress but, paradoxically, it favors tumor progression.

105 ls can increase substantially in response to stress, but toxin is not liberated.

106 We achieve this stress by bending single-crystal silicon microbeams usin

107 results demonstrated how plant physiological stress can depend on the interaction between soil proper

108 This stress can double the fracture energy or reduce it to ze

109 Autophagy can protect stressed cancer cell by degradation of damaged proteins

110 ricular ejection fraction <40%) referred for stress cardiovascular magnetic resonance (CMR) may have

111 Hyperosmotic stress caused by drought and salinity is a significant e

112 Stress causes a massive reorganization of the transcript

113 ents of the reward circuitry and interacting stress circuits.

114 re male) with suspected CAD were assessed by stress CMR and followed over a median of 5.4 years.

115 In the multicenter SPINS (Stress CMR Perfusion Imaging in the United States) study

116 th and is reversible after withdrawal of the stress condition and the PI3K inhibitor.

117 necrosis, tassel browning, and sterility, a stress condition known as "tassel blasting." We identifi

118 ds to a variety of intra- and extra-cellular stress conditions including, but not limited to, pathoge

119 Each year, abiotic stress conditions such as drought, heat, salinity, cold

120 of root morphogenesis under both normal and stress conditions.

121 cts under standard conditions and under five stress conditions.

122 P chaperone family proteins under normal and stress conditions.

123 fitness effects of mutations under different stress conditions.

124 lower diversity panel under control and salt-stressed conditions and measured a suite of morphologica

125 les in cells experiencing metabolic or redox stress confirmed that KEAP1 sheds many basal interaction

126 Here we show in mice that stress constrains the shuttling of glucose and lactate t

127 tivity in the elevated plus maze and altered stress-coping strategies in the forced swim task.

128 Recent work showed that cellular stress created by neurotoxins such as MPTP and 6-hydroxy

129 We performed chronic social defeat stress (CSDS) in mice and evaluated behavior with Psycho

130 ion (tLTP) in the chronic unpredictable mild stress (CUMS) mouse model of depression.

131 the understanding of poorly characterized ER stress-dependent RIP.

132 ay even increase prevalence of posttraumatic stress disorder (52.4% vs 37.1%; p = 0.03).

133 has enhanced extinction in a post-traumatic stress disorder (PTSD) animal model and was related to r

134 me-wide association studies of posttraumatic stress disorder (PTSD) may inform risk for this disorder

135 CANCE STATEMENT Patients with post-traumatic stress disorder (PTSD) show heightened amygdala activity

136 , a validated rodent model of post-traumatic stress disorder, in combination with optogenetic activat

137 or use in pharmacotherapy for post-traumatic stress disorder.

138 sorders such as addiction and post-traumatic stress disorder.

139 3 to initiate a slow-cycling state following stress (DNA damage, targeted therapy, and aging).

140 ered by multiple factors, including cellular stress, DNA damage and immune surveillance.

141 multiple mechanisms including the oxidative stress, DNA damage, lysosomal dysfunction, inflammatory

142 Unregulated stress during critical periods of development is propose

143 xercise and temperature-matched passive heat stress during isocapnia (i.e. end-tidal PCO2 was held co

144 pEF develop B-lines upon submaximal exercise stress echocardiography; however, whether exercise-induc

145 Additional analyses probed stress effects on the dorsal hippocampus (HPC), basolate

146 pecific effects on fear sensitization in the stress-enhanced fear learning (SEFL) model of PTSD, as w

147 Mild replication stress enhances appearance of dozens of robust recurrent

148 and continue to diverge following successive stress episodes before reaching persistent abnormal leve

149 SBR was measured before and during a low-stress event (sham clipping) and compared with heart rat

150 t to examine how trait impulsivity and acute stress exposure affect participants' choice behavior and

151 ce of stress-related stimuli following acute stress exposure.SIGNIFICANCE STATEMENT This study in rat

152 ver, had broad morphologies, formed abundant stress fibers, exhibited greater levels of alpha-smooth

153 well as biomarkers of negative responses to stress following heavy alcohol drinking.

154 Despite the potential role of ER stress for As-induced neurotoxicity, the underlying mech

155 f the nuclear envelope and its resistance to stresses found that both mutations result in similar nuc

156 for sustaining or abrogating the light- and stress-gated response.

157 We also demonstrate light- and cellular stress-gated switch function in cultured hippocampal neu

158 Lastly, MYT knockdown caused stress-gene overactivation and death in human EndoC-beta

159 r recent work demonstrated that B2 RNA binds stress genes to retard transcription elongation.

160 NA from chromatin, and activation of thermal stress genes.

161 reviously uncharacterized RBPs that modulate stress granule abundance, highlighting the applicability

162 tact sites defined the position where PB and stress granule fission occurs.

163 nuclear localization, phase separation, and stress granule recruitment of CIRBP in cells.

164 Stress granules (SGs) are cytoplasmic assemblies of prot

165 th TDP-43 and its CTD are also known to form stress granules by coacervating with RNA in the cytoplas

166 Psychological stress has adverse effects on various human diseases, in

167 endosymbiotic algae ("bleaching") under heat stress has become a major problem for reef-building cora

168 The stress hormone abscisic acid (ABA) initiates a signaling

169 htened amygdala activity; elevated levels of stress hormones, including norepinephrine; and are resis

170 e aberrant repair of spontaneous replication stress, however successful fragile site repair cannot be

171 in less than 6.5% (odds ratio = 1.08 per 0.1 stress hyperglycemia ratio increment; p < 0.001) and gly

172 .5% (48 mmol/mol) (odds ratio = 1.08 per 0.1 stress hyperglycemia ratio increment; p = 0.005).

173 Unlike admission glucose concentration, stress hyperglycemia ratio was significantly associated

174 n calcium binding decreases under mechanical stress (i.e. cbEGF domains are mechanosensitive).

175 te various size and charge variants from the stressed IgG(1).

176 y, and an impaired response to mitochondrial stress in affected cells.

177 Chronic stress in both humans and rodents induces a robust downr

178 atory processes and the effects of oxidative stress in Caco-2 cells, and preserved the integrity of t

179 mitochondrial activity and reduces oxidative stress in children with SCD/VOE.

180 Albumin induced features of ER stress in renal tubular cells with ATF3/ATF4 activation.

181 plication timing (RT) under mild replication stress in the context of the 3D genome organization.

182 s necessary for the development of oxidative stress in the retina of streptozotocin-induced diabetic

183 envelope may balance significant mechanical stresses in yeast and in cells from higher organisms.

184 pid peroxidation, a potent form of oxidative stress, in mediating RV hypertrophy and failure in conge

185 ants, higher temperatures, CO(2) and drought stress increase foliar herbivory.

186 eactive nitrogen species as well as cellular stress induced by antibiotics.

187 ar chaperones to protect other proteins from stress-induced damage.

188 ockdown in the NAc reduced susceptibility to stress-induced helplessness and increased NAc neuronal a

189 Stress-induced increases in BLA activity mediated by LC-

190 findings indicate that modulation of chronic stress-induced neuronal activity limits microglia-mediat

191 (2020) show that stress induces the release of noradrenaline from sympath

192 SF1 partner, CTCF, interacted with HSF1 in a stress-inducible manner and functions in repression of s

193 significance of using metal complexes as ER stress-inducing agents for the treatment of cancer is pr

194 ponse (UPR) signaling and cell death upon ER stress induction.

195 network hypothesis suggests that early-life stress initiates a positive feedback loop between periph

196 ibution of the peak leaf area and vegetation stress intensity was highly variable among models.

197 Under stress, intensive chloroplast protein remodeling and deg

198 Oxidative stress is a central part of innate immune-induced neurod

199 or human amyloid diseases in which oxidative stress is often an associated hallmark.

200 Although contractile stress is relatively low, myotomal muscles develop high

201 lls respond to the R loop-associated genomic stress is still poorly understood.

202 nover were significantly upregulated in heat stressed larvae.

203 tion and extended longevity, and exposure to stress led to splicing and activation of xbp-1 in these

204 s monocyte removal by amplifying the hypoxic stress manifest within monocytes in acute inflammatory l

205 he processes by which this microbiota-immune-stress matrix may influence centrally mediated events an

206 nse, and higher activation with acute mental stress may indicate a more severe stress reaction.

207 How integrin binding under shear stress mechanosignals a functional shift in iMo toward a

208 dox sensor to prevent drug-induced oxidative stress-mediated DNA damage and execution with potential

209 ondrial dysfunction and associated oxidative stress might induce senescence in joint tissue cells.

210 is present; and (c) mitochondrial oxidative stress must precede the insulin stimulus to cause insuli

211 vacuolization, possibly resulting in osmotic stress; no accumulation of multiple kinetoplasts and/or

212 There is emerging evidence that stress not only impacts high-order regions of the brain,

213 veals that olivines experienced differential stresses of ~3-12 MPa, consistent with their storage in

214 and white wine production and environmental stress on grape integrity, can increase bacterial divers

215 fflux was sufficient to mimic the effects of stress on long-term potentiation.

216 d on proteasomes, and, thus, putting further stress on their capacity for protein homeostasis.

217 plants exposed to different levels of water stress or to natural water availability, respectively.

218 However, the downstream mediators of ER stress pathway in promoting lipid accumulation remain po

219 erse health has implicated air pollution and stress pathways.

220 ip angle of the slab and predicts a detailed stress pattern related to bending down to 450 km, follow

221 drial hyper-function and increased oxidative stress, possibly resulting in neurodegeneration in non-d

222 tested whether each person's depression and stress predicted their own decisional conflict (actor ef

223 iabetes the destructive effects of metabolic stress predominate and beta cell death or dysfunction oc

224 Stress promotes negative affective states, which include

225 xercise and temperature-matched passive heat stress provoked ~16% increases in vertebral artery blood

226 The changes of stress ratio were highly consistent with clinical data o

227 ute mental stress may indicate a more severe stress reaction.

228 osystems experience, but effects of changing stress regimes are not well understood.

229 c effects on social- and affective behavior, stress regulation, and neural activity.

230 standing of the neuroanatomical basis of the stress-related feeding behaviors.

231 es the adequate and coordinated emergence of stress-related internal states.

232 approach for the treatment of affective and stress-related neuropsychiatric disorders.

233 Altered stress-related responses have also been observed in anim

234 ns are important for persistent avoidance of stress-related stimuli following acute stress exposure.S

235 -5 methylome on development, homeostasis and stress remains unknown.

236 anscription factor foxo1 are associated with stress resilience.

237 at modifies behavioral coping mechanisms and stress resiliency in mice.

238 uman therapeutic intervention and developing stress-resilient crops.

239 with heptose biosynthesis, colonization, and stress resistance.

240 Our study defines an antifolate stress response in E. coli and links its associated meta

241 ne up-regulation is a common transcriptional stress response in RTECs to ischemia-, cisplatin-, and r

242 emonstrated that increased expression of the stress response protein regulated in development and DNA

243 n this study, we investigated one such brain stress response system, pituitary adenylate cyclase-acti

244 f PP-InsPs influence the ESR through general stress response transcription factors Msn2/4.

245 important area of the brain involved in the stress response, and higher activation with acute mental

246 wever, loss of Hel2 triggered the integrated stress response, via phosphorylation of eIF2alpha, thus

247 ells to daunorubicin activated an integrated stress response-like transcriptional program to induce A

248 -dependent expression of immune function and stress response.

249 ase (CrRLK1L) and others involved in abiotic stress response.

250 d, an in vivo network consisting of selected stress-response and cambium regulators indicated ERF-1 a

251 at the defects of the bon mutants in osmotic stress responses were suppressed by mutations in the NLR

252 for this USP in mycobacterial physiology and stress responses.

253 oles in both normal plant development and in stress responses.

254 creased autophagy and up-regulation of an ER stress-responsive chaperone.

255 remodeling and activation of an ATF4-bound, stress-responsive enhancer.

256 iety of cis-regulatory elements (CREs) in ER stress-responsive gene promoters.

257 ons in plant immunity by modulating multiple stress-responsive processes in this quasi-organelle.

258 We compared stress responsiveness in four populations of tree swallo

259 stionnaire-2, and stress using the Perceived Stress Scale.

260 ected human scalp remains unclear, oxidative stress sensing appears to be a key factor involved.

261 examine regions and pathways expressing the stress-sensitive peptide corticotropin-releasing factor

262 at the level of arbor growth: Under nutrient stress, sensory dendrites preferentially grow as compare

263 alpha, the ultimate effector protein of this stress signaling cascade.

264 pture the viscoelastic modulation of nuclear stress-strain relationships by the physiological tetheri

265 range of physical, chemical, and biological stresses, support biofilms, and play critical roles in i

266 NFkappaB signaling and hdac1 as mediators of stress susceptibility.

267 This finding is corroborated in stress-susceptible male mice that have undergone chronic

268 However, protracted recruitment of stress systems can precipitate wear and tear on the body

269 he patients remained asymptomatic during the stress test.

270 y disease and moderate or severe ischemia on stress testing to be treated with an initial invasive st

271 on between MDD-PRS and depression when under stress than at baseline, suggesting that MDD-PRS adds un

272 ese changes provoke a state of persistent ER stress that has been demonstrated to govern multiple pro

273 water salinization in semi-arid context, and stress that identifying dominant drivers is crucial for

274 e intensity and variability of environmental stress that organisms and ecosystems experience, but eff

275 ichia coli has evolved to minimize metabolic stress that results from the acquisition and use of cyst

276 eptibility testing against P. aeruginosa and stress the need for P. aeruginosa-specific breakpoints.

277 Under mild or moderate levels of ER stress, the homeostatic UPR sets in motion transcription

278 ammasome activation in response to metabolic stress through induction of lncRNA Gm15441.

279 myelin loss attributed to elevated oxidative stress through NADPH oxidase in lineage-traced microglia

280 thway from adverse childhood experiences and stress to disruption of the development of neural system

281 The cumulative science linking stress to negative health outcomes is vast.

282 hile hydrogen peroxide distributes oxidative stress to sensitize the network to mitochondrial critica

283 that RPL4 loss-of-function increases osmotic stress tolerance and decreases sensitivity to cytokinin-

284 ternative translation mechanisms involved in stress tolerance and drug resistance.

285 Polkappa, to induce mutagenesis that enables stress tolerance or escape.

286 Thus, oxidative stress transcriptomics identified neurotoxic CNS innate

287 Darkness and salt stress triggered BPM1 degradation, whereas elevated temp

288 Moreover, plant iron stress triggers immune activation, suggesting that sensi

289 Two stress ulcer prophylaxis strategies were compared (prefe

290 s and promote survival following replication stress, uncovering an unexpected link between stress and

291 During adulthood, stress unmasked persistent changes in DHPG-induced LTD a

292 sing the Patient Health Questionnaire-2, and stress using the Perceived Stress Scale.

293 Replication stress was enriched in the squamous subtype of PC (P < .

294 respiratory and arousal responses to somatic stresses, whereas RTN selectively controls lung ventilat

295 disconnect between respiration and oxidative stress, whereby mitochondrial oxidant levels do not rise

296 viding cellular protection against oxidative stress while serving as a reactive oxygen species (ROS)-

297 d orchestrates thymic regeneration following stress, while thymocyte-derived LXRalphabeta limits cell

298 nction, beta-cells are prone to biosynthetic stress with limited measures for self-defence.

299 y ~43% during both exercise and passive heat stress, with no change in internal carotid artery blood

300 urgor buffering, the amelioration of osmotic stress, wounding-induced sieve tube occlusion, and possi