ライフサイエンスコーパス: structural alteration

1 ent parts of the cage can be changed without structural alteration.

2 t the observed kinetic diversity arises from structural alteration.

3 ngle-nucleotide mutations in the vicinity of structural alteration.

4 ycosylation site likely responsible for this structural alteration.

5 involve multiple chromosomes and additional structural alterations.

6 pressure-volume relationships and myocardial structural alterations.

7 in biological activity in response to minor structural alterations.

8 this activity could be abolished by multiple structural alterations.

9 gesting the first evidence in vivo of NOTCH3 structural alterations.

10 and inflammation and were protected against structural alterations.

11 he collapsed state without substantial local structural alterations.

12 from the proton release group and resulting structural alterations.

13 re helping to uncover potentially associated structural alterations.

14 giogenic markers in kidney grafts as well as structural alterations.

15 tral role of protein phosphorylation for the structural alterations.

16 extreme stability and rare examples of their structural alterations.

17 otide changes occur frequently near sites of structural alterations.

18 t position 20 (P20L), resulting in secondary structural alterations.

19 , acetylation is known to produce nucleosome structural alterations.

20 ar earlier and more predominantly than other structural alterations.

21 h the disappearance of CSR- and SHM-mediated structural alterations.

22 rol its Rab5 GEF activity through allosteric structural alterations.

23 ansgene architecture, somatic mutations, and structural alterations.

24 glomeruli did not have any major sequence or structural alterations.

25 feature of cancer that involves large-scale structural alterations.

26 Recovery sleep normalizes these structural alterations.

27 trum and associated with cognition and brain structural alterations.

28 ction evolve independently and are caused by structural alterations affecting the S-haplotype.

29 Similarly, ultrastructural analysis revealed structural alteration among hair cells within 15 minutes

30 de substitution rate is higher near sites of structural alteration and decreases with increasing dist

31 at Val-1(beta) gives rise to less pronounced structural alteration and different functional change.

32 that protein can change, either because of a structural alteration and/or a direct modification of an

33 uggests an association between the predicted structural alteration and/or damage to retinoschisin and

34 tutions and small insertion/deletions, large structural alterations and copy number events.

35 and a 3-fold increase in platelet size with structural alterations and functional impairments in act

36 lexes bind to promoters to control chromatin structural alterations and gene activation in a cell con

37 pressure (MAP) and was associated with renal structural alterations and proteinuria characteristic of

38 ecular dynamic simulations confirm the local structural alterations and the Raman sensitive band iden

39 However, characterization of complex structural alterations and their underlying mechanisms r

40 reduces atrial sympathetic nerve sprouting, structural alterations, and AF complexity in goats with

41 est that learning-induced freezing behavior, structural alterations, and enhanced neural sensory repr

42 Associated with these structural alterations are compensatory changes in the p

43 n transcripts have been reported, additional structural alterations are largely uncharacterized.

44 Thus, in the mutational landscape, structural alterations are linked to single-nucleotide c

45 l damage, whereas in minimal change disease, structural alterations are mostly transient.

46 Taken together, we demonstrate that ATRX structural alterations are not loss-of-function and put

47 Furthermore, such structural alterations are present in pediatric and adul

48 Such structural alterations are well documented to impair mit

49 The identified structural alterations are, for the most part, not consi

50 icated that the mutations caused undesirable structural alterations as evidenced by significant chang

51 iron-sulfur centers, rather than from global structural alterations as has been suggested previously.

52 novel EPHB4 mutations that lead to putative structural alterations as well as increased cellular pro

53 ar smooth muscle cells (vSMCs) can result in structural alterations associated with aneurysms and vas

54 but its functional/interaction sites and the structural alterations associated with artemisinin resis

55 Histologic studies revealed that structural alterations associated with thymic involution

56 ature that has implicated direct or indirect structural alterations at dendritic spines in the pathog

57 ens from cryptogenic patients not presenting structural alterations at imaging.

58 ular and animal model studies that implicate structural alterations at spiny synapses in the pathogen

59 Fourth, the profound structural alterations at the EPs likely contribute impo

60 Air pollution has been related to brain structural alterations, but a relationship with white ma

61 Our results show that m6A-dependent RNA structural alterations can promote direct binding of m6A

62 and binding assays, we offer evidence that a structural alteration caused by phosphorylation partiall

63 investigate whether a transdiagnostic set of structural alterations characterized schizophrenia, depr

64 ancy of the photoreceptor but is caused by a structural alteration close to the ATP-binding site.

65 valent G194C-hE3 variant primarily exhibited structural alterations close to the substitution site, w

66 al psychopathology drives the convergence of structural alterations common across disorders, then 1)

67 CR)-peptide-MHC complexes reveal substantial structural alterations compared to antimicrobial TCRs.

68 s introduced in apoE4-mut2 result in smaller structural alterations compared with those observed in a

69 nally, the SAXS data indicate a pH-dependent structural alteration consistent with either a pH-induce

70 dramatically altered pulmonary function and structural alterations consistent with enhanced remodeli

71 These structural alterations correlate with protein degradatio

72 synthesized, demonstrating that a number of structural alterations could be made while maintaining g

73 As these structural alterations did not impair functional express

74 chizophrenia phenotype, brain functional and structural alterations differentiate schizophrenic patie

75 ubunit F of V-ATPases is proposed to undergo structural alterations during catalysis and reversible d

76 The current study examined BBB structural alterations during the "BBB leakage" associat

77 Here we investigate the relationship between structural alterations (e.g., insertions and deletions)

78 Complex structural alterations emerge as a relevant early oncoge

79 g processes, resulting in macromolecular and structural alterations - features similar to those seen

80 nally greater gray matter and persistence of structural alterations following long-term recovery.

81 Although the sensitivity of detecting structural alterations from exomes is considerably lower

82 Although a number of structural alterations have been associated with the pat

83 Either modified ANP plasma levels or peptide structural alterations have been involved in development

84 This suggests that some structural alterations have to take place on the pathway

85 ight and adult emergence, possibly due to PM structural alterations impairing digestion.

86 At the species level, genes with structural alteration in nearby regions show increased s

87 Extensive structural alteration in omega6 makes it more rigid, the

88 This suggests a structural alteration in P(M) that is centered on the Hi

89 There was no significant structural alteration in the active material after micro

90 The double mutants show only slight structural alteration in the beta-heme pockets.

91 n, changes at selected sites induce a global structural alteration in the direction of an outward-ope

92 To clarify if structural alteration in these brain areas can be verifi

93 , representing the largest analysis of brain structural alterations in 22q11DS to date.

94 here that the BLIMP1 gene is inactivated by structural alterations in 24% (8 out of 34) activated B

95 sease (AD) is associated with functional and structural alterations in a distributed network of brain

96 These structural alterations in aging mitochondria correlate w

97 are now underway to understand the impact of structural alterations in autoimmune TCR-pMHC complexes

98 This was also evident from structural alterations in BAT morphology, including mito

99 Although pre-RC deficiency induces chromatin structural alterations in both nontransformed and cancer

100 f arrestin binding, we directly observed the structural alterations in both reaction partners.

101 We aimed to characterize functional and structural alterations in cerebral microvasculature befo

102 s in CC density correlate with photoreceptor structural alterations in choroideremia.

103 poisomerase-induced DNA breaks and chromatin structural alterations in conjunction with AIRE-dependen

104 f our analyses provide initial evidence that structural alterations in corticocerebellar circuitry su

105 Structural alterations in DNA can serve as natural imped

106 tration to pregnant rabbits causes permanent structural alterations in dopamine-rich cerebral cortica

107 es of intratumoral androgen synthesis and AR structural alterations in driving AR activity in CRPC, m

108 We propose that structural alterations in eIF2gamma subtly alter the con

109 variants in six patients, and ALK N-terminal structural alterations in five samples, identify additio

110 The resultant structural alterations in hippocampal neurons in vivo ar

111 hanges in their expression patterns and gene structural alterations in human tumors.

112 Structural alterations in individual posterior lobules,

113 In addition, evidence for structural alterations in key oxytocinergic regions emer

114 nderstanding of the extent and nature of the structural alterations in limb muscles in patients with

115 Using fluorescence spectroscopy to probe structural alterations in lyophilized proteins has been

116 s demonstrate that rescue is associated with structural alterations in MA organization and rescue of

117 as a key factor mediating Lkb1 loss-induced structural alterations in mammary epithelium and BM frag

118 epressive Disorder Working Group on cortical structural alterations in MDD.

119 d properties of Ac-6-FP were attributable to structural alterations in MR1 that subsequently affected

120 S.V(+) and SJL-beta2M(-/-) mice did not have structural alterations in Myc or T(12;15) translocations

121 The dATP-mediated structural alterations in myosin reported here may provi

122 rative conditions that correlate to specific structural alterations in neurons that are believed to b

123 t a different extent while they both induced structural alterations in nucleic acids.

124 um in rate, attributed to the onset of local structural alterations in or near the binding site, occu

125 ociated with cognitive dysfunction and brain structural alterations in otherwise healthy adults.

126 ctric field (PEF) treatments caused cellular/structural alterations in Oxalis tuberosa (oca) tubers a

127 , the findings provide new insights into the structural alterations in patients with dilated cardiomy

128 1 on CCL19-expressing stroma led to profound structural alterations in perivascular FRCs and associat

129 tered cocaine or food self-administration on structural alterations in PL neurons.

130 ltreatment results in similar functional and structural alterations in previously maltreated but heal

131 orts that a decrease in pH below 6.0 induces structural alterations in profilin, favoring dissociatio

132 Neuroimaging studies have shown structural alterations in several brain regions in child

133 vide evidence for a functional effect of the structural alterations in Sle1c Crry and suggest that th

134 ovel cellular and extracellular matrix-level structural alterations in term and preterm human fetal a

135 Together, these data demonstrate that structural alterations in the AR gene are linked to stab

136 atial distribution of fibrillation waves and structural alterations in the atrial free walls in a goa

137 90 mm Hg and with evidence for functional or structural alterations in the cardiovascular system.

138 ide/lyso-PL interaction was not sensitive to structural alterations in the ceramide molecule.

139 ules VI and VII are underdeveloped, while no structural alterations in the cerebral cortex are observ

140 nstrate that sialylation induces significant structural alterations in the Cgamma2 domain and propose

141 in the Xaa positions does not lead to large structural alterations in the collagen triple helix.

142 ted oligosaccharides of HS that portray fine structural alterations in the diabetic rats indicative o

143 ry by binding to the coreceptor and inducing structural alterations in the extracellular loops.

144 ormalities in aspects of face processing and structural alterations in the fusiform gyrus, part of th

145 nucleotide polymorphism genotyping to detect structural alterations in the genomic DNA of patients wi

146 Structural alterations in the hippocampus and other medi

147 e brains of Df(16)A(+/-) mice and results in structural alterations in the hippocampus.

148 ment in glandular tissues is associated with structural alterations in the hollow ducts and spherical

149 of Pseudomonas aeruginosa ClpV1 and observed structural alterations in the hydrophobic groove.

150 anges in activity, with either functional or structural alterations in the Ib neuron occurring follow

151 CF-5/20 are not related to the induction of structural alterations in the LPS or cell permeability.

152 is associated with persistent functional and structural alterations in the medial prefrontal cortex (

153 ested whether chronic social defeat produces structural alterations in the mPFC in mice.

154 PEL cells, in contrast, lack structural alterations in the MYC gene, but have deregul

155 Structural alterations in the platelet internal membrane

156 Chronic stress leads to neurochemical and structural alterations in the prefrontal cortex (PFC) th

157 The above structural alterations in the recently activated CTLs ar

158 tron microscopy further revealed PCD-related structural alterations in the TAB-meristem of BE-treated

159 The differences in intrinsic KIEs reflect structural alterations in the transition states.

160 The structural alterations in the trimolecular complex are d

161 At the earliest point, MMP-2 leads to structural alterations in the tubular basement membrane,

162 lpha-helix and the C-terminal helix, showing structural alterations in the two ScDF structures.

163 ity were accompanied by related white matter structural alterations in the uncinate fasciculus, forni

164 nd irrelevant stimuli, and is accompanied by structural alterations in the white matter of the fronta

165 ich cells of the human body normally acquire structural alterations in their DNA post-zygotically.

166 in schizophrenia reflects molecular and not structural alterations in these cells and their axon ter

167 copy tools, which fail to reveal any notable structural alterations in these regions at a submicrosco

168 thodology was applied to investigate whether structural alterations in this oligosaccharide pool, enr

169 We highlight important structural alterations in two loops flanking the dimer i

170 ) exhibited basal bradycardia but no cardiac structural alterations; in contrast, no homozygotes were

171 fuse large B-cell lymphoma--harbour frequent structural alterations inactivating CREBBP and, more rar

172 ucleotide variations and somatic large-scale structural alterations, including amplifications and del

173 channel inactivation is sufficient to drive structural alterations, including atrial and ventricular

174 aged mice revealed a variety of age-related structural alterations, including axonal swellings, spro

175 cold storage of porcine arteries by limiting structural alterations, including the collagen matrix, r

176 The resulting structural alterations indicate that LTA4 entrance into

177 Microfractures are structural alterations indicative of areas of tissue rem

178 We have found that the structural alterations induced by sialylation can be mim

179 demonstrate that Fc variants that mimic the structural alterations induced by sialylation, such as F

180 However, there are few data regarding structural alterations induced by the binding between th

181 We present evidence that structural alteration induces single-nucleotide changes

182 The degree of structural alteration is however very significant, mimic

183 This structural alteration leads to an expansion of the AR bi

184 Structural alterations led to altered mechanical propert

185 Herein, we describe structural alterations made within a lipid class exempli

186 ergo numerous physiological, biochemical and structural alterations, making them more attractive to s

187 bling experimental design techniques such as structural alteration, manipulation of anisotropy, inter

188 This structural alteration may increase helix-helix interacti

189 These structural alterations may provide DS with an additional

190 ulted in a detectable secondary and tertiary structural alteration measured by circular dichroism.

191 ther, our data establish that the Pro32Pro33 structural alteration modifies the function of integrin

192 revealed that they too contained unselected structural alterations more often than control clones ob

193 profilin-actin complex, corresponds with the structural alterations observed in the partially unfolde

194 hanisms, showing complex relationships among structural alterations observed with conventional neuroi

195 of a novel hybrid series of compounds where structural alteration of aromatic hydrophobic moieties c

196 st time that chronic alcohol exposure causes structural alteration of dendrites and their spines in t

197 plex 16p11.2 rearrangement involving de novo structural alteration of KCTD13.

198 nt with a mechanism involving a mAb-mediated structural alteration of P1 on the cell surface, immuniz

199 demonstrate that centrosome amplification, a structural alteration of the cytoskeleton, can promote f

200 ated by both DNA sequence information and by structural alteration of the duplex.

201 tribute to NAA10 activity inhibition through structural alteration of the NAA10 substrate-binding sit

202 tethering, but is inhibited by HYPK through structural alteration of the NatE substrate-binding site

203 late diaphragmatic dysfunction related to a structural alteration of the ryanodine complex that is r

204 contributes to tRNA binding and suggesting a structural alteration of the substrate-binding pocket oc

205 P-43, FUS, and hnRNPA2B1, bind to and induce structural alteration of UGGAAexp.

206 triggered allergic lungs with functional and structural alterations of airways.

207 idespread transport deficits, which preceded structural alterations of axons, cargos, or microtubules

208 ime to our knowledge, an association between structural alterations of bronchi and PH in COPD.

209 nine (42.9%), Amadori products, and resisted structural alterations of BSA subjected to glycation.

210 Widespread structural alterations of cancer genomes are increasingl

211 Structural alterations of cerebellar circuitry have emer

212 istone H3S10 phosphorylation are a result of structural alterations of chromatin.

213 impaired alcohol seeking was associated with structural alterations of dendritic spines in the CeA an

214 n in keratinocytes of transgenic mice causes structural alterations of epidermal desmosomes.

215 le aspects of asthma pathogenesis, including structural alterations of epithelial cells and smooth mu

216 , as a synthetic starting point for dramatic structural alterations of its complex, fused ring system

217 Aging was associated with profound structural alterations of murine uterine arteries, inclu

218 ffects of alcohol exposure and withdrawal on structural alterations of NAc MSNs.

219 VP37-tubule generation also induced structural alterations of PD as well as modifications to

220 as a sensitive indicator for monitoring the structural alterations of proteins that are often associ

221 that these mutations may result in critical structural alterations of RPE65 protein, disrupt its mem

222 id changes provided preliminary evidence for structural alterations of the A-, B- and/or C-helices wi

223 a is the only strain identified to date with structural alterations of the capsule polysaccharide Gal

224 We compared the extent of structural alterations of the CC, retinal pigment epithe

225 s reflected in a local unfolding or in other structural alterations of the collagen triple helix is u

226 oteins was associated with pronounced (ultra)structural alterations of the elastic fiber network in t

227 ngle-nucleotide substitutions to large-scale structural alterations of the genome.

228 retardation syndrome that is associated with structural alterations of the GLP/EHMT1 gene.

229 ulmonary artery banding, not associated with structural alterations of the lung circulation) was comp

230 wever, these are jeopardized by chemical and structural alterations of the NCs induced by the environ

231 nuclear envelope (NE) that is accompanied by structural alterations of the NE.

232 recociously in an MU-specific manner, before structural alterations of the NMJ.

233 s, however, unknown whether it is related to structural alterations of the retina.

234 Together, these data suggest that structural alterations of the retinal dopaminergic netwo

235 In this study, we explore the properties and structural alterations of the S512R mutation in GlyT2.

236 e a change in illumination did not result in structural alterations of the synaptic ribbon.

237 odulate the size of conduit arteries through structural alterations of the vessel wall that are depen

238 , this mutation induces major functional and structural alterations of the whole trimeric langerin ex

239 Due to their slow photocycle, structural alterations of these proteins can be studied

240 Neuroimaging studies show structural alterations of various brain regions in child

241 Structural alterations on medium spiny neurons (MSNs) of

242 correlated with demographic characteristics, structural alterations on optical coherence tomography a

243 molecule assays to assess the impact of gRNA structural alterations on RNP complex formation, R-loop

244 Further structural alterations on these two alleles begin to rev

245 The majority showed extensive structural alterations (one had an ultramutated profile)

246 d proteolysis studies suggested little or no structural alteration outside of the C-terminal region.

247 ), neurophysiological (P < 0.001), and brain structural alterations (P = 0.001).

248 The structural alterations parallel those observed in models

249 morphology in wild-type macrophages, similar structural alterations persist in CCT alpha-deficient ce

250 The role that these structural alterations play in overall catalysis and pot

251 Even minute structural alterations preclude it from assisting in rib

252 s seen in patients with tumors carrying CDH1 structural alterations, preferentially those belonging t

253 ole-genome paired-end sequencing to identify structural alterations present in a primary PCa patient

254 xtent of strain background polymorphisms and structural alterations present in the host strain, which

255 Structural alterations ranged from precipitate-like alte

256 These structural alterations render the enzyme inactive.

257 The structural alterations suggest functional changes in end

258 EGFR compared with WT, rather than from any structural alteration that impairs the donor role of the

259 , 9p24.1 amplification is a disease-specific structural alteration that increases both the gene dosag

260 ious types of human cancer to IDH1(R132H), a structural alteration that leads to catalysis of alpha-k

261 pocket to facilitate linker dynamics and the structural alterations that accompany drug binding of th

262 t aberrant DNA transposase activity promotes structural alterations that are clonally selected to dri

263 n alleles are among the largest possible RNA structural alterations that can be induced by a single n

264 Computational analysis suggested structural alterations that could provide additional int

265 riments demonstrate that SAM binding induces structural alterations that indirectly stabilize the apt

266 ms that electrophile-protein adducts produce structural alterations that influence biological functio

267 is a useful microscopy tool that can detect structural alterations that may affect product propertie

268 the structure-function of the MuV NC and the structural alterations that occur through its interactio

269 hed on a classification system for OCT-based structural alterations that occurred before the developm

270 herin mutations and calcium depletion induce structural alterations that propagate from the N terminu

271 ling the hydrolysis of one ATP molecule into structural alterations that result in movement of approx

272 eptic and pancreatic digestion attributed to structural alterations that resulted in much lower antig

273 a limiting factor, and the morphological and structural alterations that the nucleus encounters can p

274 demonstrated prevention of podocyte loss and structural alterations, the absence of vascular congesti

275 Despite these structural alterations, they exhibited similar respirati

276 This labeling method causes minimal structural alteration to peptidyl phosphates and allows

277 ociated with auditory-cognitive deficits and structural alterations to auditory thalamocortical syste

278 he fluorine atom can be used to make defined structural alterations to biologically important molecul

279 Mitochondria undergo dynamic structural alterations to meet changing needs and to mai

280 s to prevent corpus cavernosal smooth muscle structural alterations to not only maximize the chances

281 As permanent structural alterations to the cornea after laser-assiste

282 nction through distinct mechanisms involving structural alterations to the nucleosome.

283 e residue is predicted to induce substantial structural alterations to the protein complex.

284 in-domain dimer does not undergo significant structural alteration upon interaction either with class

285 le retaining the capability to undergo large structural alterations upon metal ion binding.

286 1.8-2.2 A for the various mutants to compare structural alterations vis a vis the wild type protein.

287 Using tumor-specific structural alterations, we developed an approach to iden

288 for the presence of copy number changes and structural alterations, we identify key events in the ev

289 acterized by numerous non-random chromosomal structural alterations, we sought to delimit regions of

290 Analogous molecular and structural alterations were also found in human Rasmusse

291 At the cellular level, however, subtle structural alterations were evident.

292 Finally, these structural alterations were noted to persist following a

293 Importantly, these structural alterations were significantly associated wit

294 y viewed, these 3D structures reveal complex structural alterations whereby photoisomerization of the

295 iferation defects but did result in arterial structural alterations, which frequently led to aortic r

296 expense of lignin content and induced lignin structural alterations, with an unexpected increase of l

297 t higher p factor scores are associated with structural alterations within a cerebello-thalamo-cortic

298 often not capable of distinguishing the fine structural alterations within FA isomers and often limit

299 gate the biologic links between cellular and structural alterations within facet joint components and

300 Both structural alterations within pre-existing collagen matr