ライフサイエンスコーパス: structural biology

1 e proteins and are indispensable reagents in structural biology.

2 copists to break into the world of molecular structural biology.

3 equilibrium through rapid kinetics and X-ray structural biology.

4 pt, and this remains an immense challenge in structural biology.

5 ocalization in the cell is central to modern structural biology.

6 als chemistry, geochemistry, biophysics, and structural biology.

7 ts in a complex interact is a cornerstone of structural biology.

8 ctrometry (HDX-MS) is now common practice in structural biology.

9 data from diverse experimental approaches in structural biology.

10 highlight emerging challenges in nucleosome structural biology.

11 e field of G protein-coupled receptor (GPCR) structural biology.

12 rane-spanning proteins is a key challenge in structural biology.

13 es to bridge knowledge gaps between cell and structural biology.

14 to describe with the established concepts of structural biology.

15 emistry, nanoscale physics, nanomedicine and structural biology.

16 eering research in molecular recognition and structural biology.

17 by advances in computational, molecular and structural biology.

18 res of proteins remains a major challenge in structural biology.

19 , which have resulted in amazing progress in structural biology.

20 is an outstanding challenge in the field of structural biology.

21 to characterize with existing techniques in structural biology.

22 o-EM structure determination is transforming structural biology.

23 ding an exceptionally challenging target for structural biology.

24 s to advances in biochemistry, genetics, and structural biology.

25 me fashion, greatly enabling applications in structural biology.

26 multidomain proteins is still a challenge in structural biology.

27 s to be used to address problems relevant to structural biology.

28 osomes is still one of the key challenges in structural biology.

29 such as UCSF Chimera, are a standard tool in structural biology.

30 dvances in G protein-coupled receptor (GPCR) structural biology.

31 X-ray lasers for advancing the frontiers of structural biology.

32 esolution EM maps should prove invaluable in structural biology.

33 ns in atomic detail is a major challenge for structural biology.

34 tance constraints is an important problem in structural biology.

35 r complexes are an important new approach to structural biology.

36 ir native environment is the ultimate aim of structural biology.

37 plant Striga hermonthica using chemical and structural biology.

38 of activity in computational biophysics and structural biology.

39 epresents a grand challenge in chemistry and structural biology.

40 s, which opens perspectives as a new tool in structural biology.

41 l tool in the advancement of high-resolution structural biology.

42 heir properties for specific applications in structural biology.

43 topology needed for biological activity and structural biology.

44 fficult to apply to them standard methods of structural biology.

45 recent advances in 7 transmembrane receptor structural biology.

46 implementation and application of MicroED in structural biology.

47 one of the major challenges in computational structural biology.

48 ontribute to benchmarking smFRET for dynamic structural biology.

49 ding their utility for different problems in structural biology.

50 eported here may enable many applications in structural biology.

51 ensively pursued, facilitated by advances in structural biology.

52 used together to tackle complex problems in structural biology.

53 mains a major bottleneck in membrane protein structural biology.

54 cular complexes has changed the landscape of structural biology.

55 ein-protein and protein-DNA networks and for structural biology.

56 zole substituents, their exact binding mode, structural biology, 3D conformations, and in general the

57 e twentieth anniversary of terpenoid cyclase structural biology: a trio of terpenoid cyclase structur

58 that employs methodologies transplanted from structural biology, adapted to giant supramolecular asse

59 use in all areas of cell research, including structural biology, advanced microscopy, and intracellul

60 A growing area of structural biology aims to characterize these dynamic st

61 The correct affiliation is Anatomy and Structural Biology, Albert Einstein College of Medicine,

62 ed protein profiling, yeast mutagenesis, and structural biology allowed us to decipher significant di

63 s of proteins could make a powerful tool for structural biology and be useful for proteomics and imag

64 Through structural biology and biochemical approaches we demonst

65 Using structural biology and biochemical approaches, we show t

66 Here, using structural biology and biochemistry, we report that the

67 try is providing invaluable contributions to structural biology and biochemistry.

68 other for large scale protein production for structural biology and biophysics studies.

69 ion in materials and medicinal chemistry and structural biology and biotechnology.

70 Because it bridges structural biology and cell biology, cryo-ET is indispen

71 ome a powerful technique at the interface of structural biology and cell biology, due to its unique a

72 nding their pharmacology through the lens of structural biology and describe how this knowledge sugge

73 ques that have led to these advances in GPCR structural biology and discuss how they may influence th

74 ing application of gas-phase measurements in structural biology and drug discovery, the factors that

75 s advanced rapidly through genetic analysis, structural biology and electrophysiology.

76 on of datastores, e.g. SBGrid Consortium for structural biology and Gene Expression Omnibus (GEO) for

77 As such, this work combines knowledge from structural biology and genomics, and suggests a new path

78 ing biochemical reconstitution combined with structural biology and high-resolution cellular imaging.

79 SF(5) groups opens unique opportunities for structural biology and in vivo studies.

80 Here, we review the recent advances in TRPM8 structural biology and investigate the molecular princip

81 The recent progress in structural biology and live-cell imaging shows the T6SS

82 can look forward to complementary data from structural biology and molecular simulations combining t

83 in optical and electron microscopic imaging, structural biology and molecular techniques have facilit

84 ral anesthetics, coincident with progress in structural biology and molecular, cellular, and systems

85 an optimally stable MP that is suitable for structural biology and other biophysical studies.

86 ntral question to G protein coupled receptor structural biology and pharmacology: What chemical featu

87 discuss recent advances in the biochemistry, structural biology and physiology of CDI.

88 ary structures is a fundamental procedure in structural biology and protein bioinformatics.

89 on of biological, pharmacological, chemical, structural biology and protein network data, it provides

90 ocused on enabling a deeper understanding of structural biology and providing new structural views of

91 the power of cellular tomography for in situ structural biology and sheds light on a very abundant cl

92 iders recent advances in glycosyltransferase structural biology and site-directed mutagenesis, pathwa

93 Here, we describe the use of both structural biology and somatic variation to develop opti

94 Structural biology and spectroscopy approaches have led

95 ntly used and integrated in several areas of structural biology and structural bioinformatics.

96 strategy will help advance insights into the structural biology and systems biology of cell signaling

97 ew, we provide a brief introduction into RNA structural biology and then describe how RNA structures

98 Here, by combining enzymology, structural biology, and activity-based metabolomics, we

99 Recent advances in disease modeling, structural biology, and an improved understanding of RAS

100 ing: functional assays, biophysical studies, structural biology, and biochemical high throughput scre

101 As an example of how genome data, structural biology, and biochemistry integrate into a re

102 Experimental information from microscopy, structural biology, and bioinformatics may be integrated

103 used a combination of immunological assays, structural biology, and cheminformatics to construct a r

104 rvesting and nanoscale energy transport, RNA structural biology, and immune receptor signaling, with

105 ances in genetics, microscopy, biochemistry, structural biology, and physical characterization method

106 Using a combination of mutagenesis, structural biology, and single molecule spectroscopy, we

107 cell fractionation to immunoprecipitation to structural biology, and the multidisciplinary approaches

108 dge of the evolutionary biology, immunology, structural biology, and virology of influenza virus is i

109 For structural biology applications that depend on side-chai

110 aluable complementary method in the field of structural biology, applications concerning membrane pro

111 model for the TSHR we applied an integrated structural biology approach combining computational tech

112 an integrated transcriptomic, proteomic, and structural biology approach to demonstrate that the leth

113 the power and versatility of this synthetic structural biology approach to probing molecular and cel

114 Using a hybrid structural biology approach together with the ECD and 7T

115 we analyze PMT-MIR domains by an integrated structural biology approach using X-ray crystallography

116 Using a biochemical and structural biology approach, we demonstrate that the onl

117 Here we employ a 'systems structural biology' approach to functionally characteriz

118 ansient nucleation complex using traditional structural biology approaches challenging.

119 Comprehensive biochemical and structural biology approaches permitted us to delineate

120 Thus, we employed biochemical and structural biology approaches to investigate the interac

121 Here, we combined biochemical and structural biology approaches with ensembles of RNA-prot

122 Employing an array of biochemical and structural biology approaches, including in vitro kinase

123 ines requires multidimensional molecular and structural biology approaches.

124 a formidable challenge and requires in situ structural biology approaches.

125 ral constraints in these ESs by conventional structural biology approaches.

126 ing information complementary to traditional structural biology approaches.

127 , an organism that has resisted conventional structural-biology approaches, to obtain atomic models o

128 Advances in structural biology are also shedding new insights into m

129 is review describes how advances in cell and structural biology are uncovering in growing detail how

130 e follows the broader, 50-year trajectory of structural biology, as I could rarely resist opportuniti

131 nd straightforward tool for biochemistry and structural biology, as it does not recur to nitrogen-15

132 In this Review, we discuss the structural biology aspects and mechanisms of catalysis b

133 owing opportunities for integrative, dynamic structural biology at the atomic scale, contending there

134 acterization of 17 recombinant proteins with structural biology-based investigations in the context o

135 oteins have been one of the 'blind spots' in structural biology because they are generally very hydro

136 ections, such as directed material assembly, structural biology, biocatalysis, DNA computing, nanorob

137 ative program combining medicinal chemistry, structural biology, biochemical testing, and microbiolog

138 The PCDDB has found broad usage by the structural biology, bioinformatics, analytical and pharm

139 l enable future applications in the areas of structural biology, biophysics, and biopharmaceutical ch

140 s fields in natural science, as for instance structural biology, biophysics, and molecular nanotechno

141 with possible application in fields such as structural biology, biophysics, synthetic biology and ph

142 has important applications in the fields of structural biology, biotechnology, and biopharmaceutics.

143 of workflows for applications in comparative structural biology, biotherapeutic analysis, and high th

144 perties not only in the traditional field of structural biology but also in the growing research area

145 lar couplings (RDCs) are important probes in structural biology, but their analysis is often complica

146 likely accelerate the development of dynamic structural biology by identifying transient conformation

147 the saccharide detergents widely employed in structural biology can cause unfolding of membrane prote

148 ombination of phylogenetics, bioinformatics, structural biology, cell biology, and biochemistry, we h

149 merging tools in a variety of fields such as structural biology, cell imaging, and drug discovery.

150 rse research fields including, synthetic and structural biology, cellular reprogramming and functiona

151 of scientists including those interested in structural biology, cloning, glycobiology and chemical b

152 In structural biology, collision cross sections (CCSs) from

153 Here, we use integrative structural biology combined with yeast genetics and bioc

154 exibilities provide a unique resource to the structural biology community that can be computationally

155 unique opportunities to a rapidly developing structural biology community where there is increasing i

156 SAXS) has become much more accessible to the structural biology community.

157 native MS has become well established in the structural biology community.

158 ng based on recent insights into immunology, structural biology, computational biology, and immunoeng

159 As structural biology continues to provide increasingly hig

160 d signals, which are problematic for in situ structural biology, contribute specifically to the inter

161 al efforts in the area of chemokine receptor structural biology could dramatically increase the outco

162 arative biology, experimental evolution, and structural biology, could thoroughly determine how viral

163 proteins function was resolved, in part, by structural biology coupled with immunological and biolog

164 e (super)families, exploiting both available structural biology data and conformational similarities

165 n data publication and dissemination system, Structural Biology Data Grid (SBDG; data.sbgrid.org), to

166 Here, we integrate biophysical and structural biology data to reveal how these mutations le

167 constructing realistic geometric meshes from structural biology data.

168 ic developments that have benefited from new structural biology data.

169 one of the best represented proteins in the structural biology database.

170 Structural biology enables determination of atomic struc

171 Action on Native MS and Related Methods for Structural Biology (EU COST Action BM1403) as an introdu

172 ve Mass Spectrometry and Related Methods for Structural Biology (EU COST Action BM1403), which involv

173 tely recover interaction modes discovered by structural biology experiments.

174 ckly mine the entire PDB to generate desired structural biology features.

175 DEM) has become a key experimental method in structural biology for a broad spectrum of biological sp

176 esis, experimental evaluation, modeling, and structural biology for a novel series of sulfonamide hyd

177 S) has evolved as an alternative strategy in structural biology for characterizing three-dimensional

178 The limitations of conventional methods of structural biology for fibril characterization have led

179 e X-ray crystallography has been a staple of structural biology for more than half a century and will

180 Using structural biology, functional assays, and molecular dyn

181 Integrative structural biology has advanced our understanding of the

182 Structural biology has benefited greatly from previously

183 ing use of mass spectrometry in the field of structural biology has catalyzed the development of many

184 l such therapeutics target beta-tubulin, and structural biology has explained the basis of their acti

185 Structural biology has played a key role in understandin

186 G protein-coupled receptor (GPCR) structural biology has progressed dramatically in the la

187 ified tens of thousands of interactions, and structural biology has provided detailed functional insi

188 ess of cryo-electron microscopy (cryo-EM) in structural biology has raised an urgent need for robust

189 Structural biology has recently documented the conformat

190 Structural biology has since precisely revealed those bi

191 Alan Fersht, a pioneer in the field of structural biology, has studied the wild-type (wt) and o

192 Despite advances in ribosome structural biology, identifying the protein and rRNA res

193 inal contributions to science in general and structural biology in particular.

194 onstrating an increasingly important role in structural biology in situ.

195 rted by complementary insight from expanding structural biology initiatives.

196 t knowledge from genetics, biochemistry, and structural biology into detailed molecular descriptions

197 This correlation and its potential uses for structural biology is discussed.

198 Structural biology is entering an exciting time where ma

199 Fundamental to the central goals of structural biology is knowledge of the energetics of mol

200 An unrealized goal in structural biology is the determination of structure and

201 A primary reason for the intense interest in structural biology is the fact that knowledge of structu

202 One of the great ambitions of structural biology is to describe structure-function rel

203 The goal of structural biology is to understand biological macromole

204 One goal of structural biology is to understand how a protein's 3-di

205 While cryo-EM is revolutionizing structural biology, its impact on enzymology is yet to b

206 r method employs only simple tools that most structural biology laboratories can access.

207 nsured that only high-quality data enter the structural biology literature.

208 e is a long history of muscle biophysics and structural biology, many of the mechanistic details that

209 Using structural biology, mass spectrometry and cross-linking,

210 s spectrometry (XL-MS) to make systems-level structural biology measurements in complex biological sa

211 Overall, our studies show that structural biology methods are ideal for stabilizing int

212 Here we employ structural biology methods to identify stable VKOR and V

213 and are difficult to study with conventional structural biology methods.

214 and therefore remain "unseen" by traditional structural biology methods.

215 therefore not easily amenable to traditional structural-biology methods.

216 Alushin investigates the structural biology of biomechanical processes in the cyt

217 we describe the recent progress made in the structural biology of both the relaxosome and the T4SS.

218 New insights into the structural biology of disaggregation obtained from NMR s

219 ant achievement, a full understanding of the structural biology of facilitative glucose transport rem

220 blot analysis to elucidate the function and structural biology of glycoprotein E-selectin ligands ex

221 Recent advances in the structural biology of GPCRs, along with biophysical and

222 Utilizing recent advances in the structural biology of GPCRs, homology modeling has been

223 Recent advances in structural biology of HIV-1 Env and its complexes with t

224 Therefore, a central question for the structural biology of IFs is whether individual subunits

225 Dramatic developments witnessed in the structural biology of membrane proteins continue to reve

226 face area, concepts that originated from the structural biology of proteins.

227 discuss both the biology and the underlying structural biology of RORc, and summarize the RORc modul

228 Despite recent advances in the structural biology of this protein family, the mechanism

229 Recent revolutions in the structural biology of transmembrane proteins have, for t

230 arried out with the determination of further structural biology on the lead series, affording derivat

231 However, structural biology only provides a few "snapshots" of pr

232 and algorithms for common tasks in genomics, structural biology, ontologies, phylogenetics, and more.

233 s a resource for researchers studying kinase structural biology or developing conformation-specific k

234 s emerged as a critical and flexible tool in structural biology, particularly in the study of highly

235 roved understanding of FGF signalling from a structural biology perspective, and of its roles in skel

236 beta2m aggregates are challenging targets in structural biology, primarily due to their inherent tran

237 models and indispensable for development of structural biology processing methods.

238 pharmacological, drug and chemical data with structural biology, protein networks and druggability da

239 pharmacological, drug and chemical data with structural biology, protein networks and unique, compreh

240 in complexes with potential implications for structural biology, proteomics, biomarker detection and

241 opments in G protein-coupled receptor (GPCR) structural biology provide insights into GPCR-ligand bin

242 optimization of a second Bicycle, guided by structural biology, provided a high affinity, metabolica

243 S) is a technology of growing importance for structural biology, providing complementary 3D structure

244 Structural biology relies on specific file formats to co

245 -CoV, and might become an important tool for structural biology, serology, vaccine design and immunol

246 the growing utilization of CIU as a tool for structural biology, significant challenges have emerged

247 om multiple experimental systems biology and structural biology sources.

248 Modern structural biology still draws the vast majority of info

249 Structural biology strives to capture biomolecular struc

250 ctivity relationship (SAR) efforts driven by structural biology studies led to the discovery of pyrid

251 itors have been identified, but only limited structural biology studies of IDO1 inhibitors are availa

252 cture-activity relationship, UV spectra, and structural biology studies of several analogues of 24 de

253 te plasticity seen here is expected to drive structural biology studies on CaADH, while the exception

254 Structural biology studies performed inside cells can ca

255 roadens the pool of possible biochemical and structural biology studies, as well as greatly enhances

256 Here, with insights from structural biology studies, we report the development of

257 h will allow for high-throughput and dynamic structural biology studies.

258 -down proteomics and mass spectrometry-based structural biology studies.

259 We report here the results of an integrated structural biology study designed to distinguish between

260 the best of our knowledge, this is the first structural biology study to directly observe how changes

261 aches play an increasingly important role in structural biology, taking advantage of the complementar

262 lectron microscopy (cryo-EM) is an expanding structural biology technique that has recently undergone

263 XL-MS is a structural biology technique that provides information o

264 oss-linking mass spectrometry is an emerging structural biology technique.

265 al changes is notoriously difficult, as many structural biology techniques are also affected by these

266 The three mainstay structural biology techniques are X-ray crystallography,

267 Classical structural biology techniques have revealed detailed sna

268 l overcomes hurdles typically encountered by structural biology techniques such as X-ray crystallogra

269 en-deuterium exchange MS (HDX-MS) with other structural biology techniques to probe the mechanistic b

270 ld be difficult to obtain with more standard structural biology techniques.

271 structure of which has yet to be defined by structural biology techniques.

272 p as a significant complement to traditional structural biology techniques.

273 ving systems is now ushering in a new era of structural biology that is leading to fundamentally new

274 trated using phylogenetics, biochemistry and structural biology that this cysteine-thiol lyase (C-T l

275 can improve our fundamental understanding of structural biology, the molecular basis of diseases, and

276 rotein crystallography" began to morph into "structural biology." The course of the research recounte

277 to cloning and sequencing to biochemistry to structural biology to an understanding of how proteins e

278 at multiple levels of resolution (e.g., from structural biology to cell biology).

279 tocol that exploits the power of integrative structural biology to characterize conformational ensemb

280 Here, we used structural biology to determine how a group of PfEMP1 pr

281 importance for future PELDOR applications in structural biology to develop suitable approaches that c

282 e complementary approaches that combine with structural biology to explore the binding capabilities o

283 We used structural biology to identify hydrophobic patches on 10

284 ) adapted molecular visualization tools from structural biology to render and analyze complex cell su

285 ged from innovations in basic immunology and structural biology to treatments for immune-mediated dis

286 ccessful immune response has been to utilize structural biology to uncover the molecular details of a

287 We used integrative structural biology to visualize the architecture of the

288 -MS) has become an important addition to the structural biology toolbox, but separating closely relat

289 Few structural biology tools presently have the combined spa

290 of human membrane proteins is a challenge in structural biology towards drug discovery.

291 Advances in structural biology unravel a rich repertoire of molecula

292 spectra in NMR have empowered proteomics and structural biology, we envisage that hyperdimensional im

293 seeligeri Using genetics, biochemistry, and structural biology, we found that AcrVIA1 interacts with

294 lar assemblies remains a challenging task in structural biology when using integrative modeling appro

295 s) used to be the most difficult targets for structural biology when X-ray crystallography was the ma

296 en difficult in the core subjects of current structural biology, which include multidomain and intrin

297 The concurrent evolution of experimental structural biology with biomolecular computer modelling

298 Here, we combined NMR structural biology with high-throughput iCLIP approaches

299 t yet available, rapid progress in combining structural biology with other techniques is revealing th

300 tive site should provide important tools for structural biology, yielding insight into substrate gati