ライフサイエンスコーパス: structural motif

1 olecular HER catalysts based on a MoO(S2)2L2 structural motif.

2 common, tricyclic spirolactone core as a key structural motif.

3 large number of proteins that lack a common structural motif.

4 p-economical enantioselective access to this structural motif.

5 e to the long-range commensurately modulated structural motif.

6 emical modifications available for the enone structural motif.

7 of photochromic molecules based on the imine structural motif.

8 dem repeating a simple helix-loop-helix-loop structural motif.

9 trix with triple helix as the characteristic structural motif.

10 cting single stereoisomers of this important structural motif.

11 al signature of the [U(mu-O)2U] diamond core structural motif.

12 nds that contain the pyrrolodiketopiperazine structural motif.

13 phosphodiester analogues containing a P-B-N structural motif.

14 ain IV that features a carboxypeptidase-like structural motif.

15 Carbocyclic decalin is a ubiquitous bicyclic structural motif.

16 pitope-focused immunogens displaying complex structural motifs.

17 haracterized by 2,3-alkanediol/hydroxyketone structural motifs.

18 ear combination of high- and low-temperature structural motifs.

19 ding of the folding properties of individual structural motifs.

20 econdary metabolites that possess intriguing structural motifs.

21 with a wide variety of functional groups and structural motifs.

22 eported crystal structures featuring unusual structural motifs.

23 size and sequence discrimination within RNA structural motifs.

24 lored in several classes of biomolecules and structural motifs.

25 oader match with metastable, non-crystalline structural motifs.

26 ting a wide variety of biologically relevant structural motifs.

27 eld low-valent group 14 compounds with novel structural motifs.

28 ploration beyond conventional strategies and structural motifs.

29 cages in EMFs by just counting three simple structural motifs.

30 and found evidence for the existence of new structural motifs.

31 ors of these kinases usually carry analogous structural motifs.

32 te localization of proteins via a variety of structural motifs.

33 rials combining nanoscale and supramolecular structural motifs.

34 ions/clusters, yielding myriads of possible structural motifs.

35 le-core (island) and multicore (archipelago) structural motifs.

36 itectures, folds and conformity to conserved structural motifs.

37 , superior to Clog P predictions based on 2D structural motifs.

38 Functional RNAs however, contain versatile structural motifs.

39 clic pyrrolidine (Aoc), and methyl-threonine structural motifs.

40 lize loop, turn, and alpha-helical secondary structural motifs.

41 asso Bundle (PLB) and the knot-like threaded structural motif a Pierced Lasso (PL).

42 We show that this structural motif, a minimal Pro(314)-Trp(316) turn, is e

43 lso expands our understanding of the diverse structural motifs achievable with modified nucleic acid

44 form of the protein in which an Asp-Phe-Gly structural motif along the activation loop adopts a so-c

45 els, encircling larger octagonal channels, a structural motif also found in some zeolites.

46 body BLV1H12 folds into a novel "stalk-knob" structural motif and has been exploited to generate nove

47 topologically featureless, embodying both a structural motif and surface topology previously conside

48 sses an ancestral, spironolactone-as-agonist structural motif and that spironolactone treatment in vi

49 of functionalized alpha-tetralones-a common structural motif and versatile building block in organic

50 he coiled-coil dimer is a widespread protein structural motif and, due to its designability, represen

51 d ligands is reviewed on the basis of common structural motifs and available crystal structures.

52 Knowledge of these structural motifs and binding mode should facilitate the

53 The effects of structural motifs and cluster-cage interactions on forma

54 he cation is therefore critical in directing structural motifs and dictating the resulting hydrogen a

55 nadate compounds reveals the key role of VO4 structural motifs and electronic band-edge character in

56 sferases that share homologous sequences and structural motifs and have many connections to cancer.

57 Oxetanes offer exciting potential as structural motifs and intermediates in drug discovery an

58 ranslation of chirality and asymmetry across structural motifs and length scales plays a fundamental

59 critical for signaling, including all major structural motifs and molecular interfaces.

60 and reconcile crystallographically observed structural motifs and non-covalent interaction acceptor-

61 andin J(3) (Delta(12)-PGJ(3)), whose unusual structural motifs and potent cytotoxicities present uniq

62 However, piRNAs lack conserved structural motifs and show relatively low sequence simil

63 c replacement concepts to eliminate unwanted structural motifs and to improve the inhibitor character

64 es of enzymes and the correlation of protein structural motifs and translational pausing.

65 ular but complex energetic properties of RNA structural motifs and will aid in the eventual quantitat

66 into nanosheets that inherited the hole/edge structural motifs and, under certain conditions, possess

67 ructures, including changes in the size of a structural motif, and revealed modification sites that p

68 lore sHsps, expand our understanding of sHsp structural motifs, and provide a testable Hsp21 structur

69 The two structural motifs are connected through an acetylene lin

70 Next, the molecular structural motifs are identified by querying these chemi

71 These dimeric structural motifs are important building blocks for the

72 and (single-core) or archipelago (multicore) structural motifs are photo-oxidized on artificial seawa

73 l space, providing the possibility for novel structural motifs as well as useful quantities of less a

74 Structural motifs at the cleavage sites of starch, beta-

75 Here, we present the structural motif-based approach "SUMMIT Motif" for the d

76 be recognizable because they have repeating structural motifs, but mimicry of these does not have to

77 he dimerization interface of a transmembrane structural motif called GASright, which is characterized

78 A structural motif called the G-box in the centriole outer

79 in guanine-rich DNA, here we show that this structural motif can be exploited to guide the self-asse

80 Specific RNA sequences and structural motifs can also enhance activation of OAS1 th

81 Detection of such structural motifs can provide valuable insights into the

82 Solution studies suggest a robust structural motif capable of assembling as a tetramer of

83 d conventional tools as well as a search for structural motifs characteristic of scorpion venom compo

84 is selectively converted to the 1,4-diketone structural motif common to the herqulines via initial hy

85 The X-ray structure of ClbM shows a structural motif common to the recently described MATE f

86 otochromic properties, and how the different structural motifs compare under identical conditions.

87 erestingly, both PrV gH and EBV gH contain a structural motif composed of a DB and supporting amino a

88 over because the addition of new topological structural motifs consistent with cubic ice leads to the

89 The beta-ketoester structural motif continues to intrigue chemists with its

90 Our study reveals that several conserved structural motifs contribute to efficient host cell bind

91 However, no known structural motifs could be identified from its sequence,

92 These studies revealed a suite of structural motifs critical for ligand activity.

93 acids and we show that this patch defines a structural motif crucial for MapZ function.

94 We use a set of NTP binding sub-structural motifs derived from a previous study and scan

95 les real-time retrieval and superposition of structural motifs, either extracted from a reference str

96 s demonstrates the broad design space of DNA structural motifs, enriching the toolbox of DNA tile-bas

97 TGF-beta monomer, lacking the heel helix, a structural motif essential for binding the TGF-beta type

98 Numerous variations on structural motifs exist within pharmaceutical compounds

99 e-and-conquer strategy that identifies their structural motifs first.

100 hexagonal vacancy as a new and more flexible structural motif for borophene.

101 vides constraints for using this pH-adaptive structural motif for creating DNA-based nanomaterials.

102 of proMPO-processing proconvertase, (ii) the structural motif for subsequent cleavage to the heavy an

103 T@Gan) endohedral Ga-clusters as a favorable structural motif for superconductivity and develop empir

104 The structural motif for the localisation of the mid-gap sta

105 mental method to determine the importance of structural motifs for biological function.

106 clopropyl ketones were recognized as crucial structural motifs for C-C bond formation.

107 blishes the extracellular loops as important structural motifs for ion selectivity and channel inhibi

108 sorption spectroscopy (IRAS) to identify the structural motifs formed upon interaction of water with

109 and furnishes cycloadducts with a prominent structural motif found in many natural products.

110 lo[3.3.1]nonane architecture is a privileged structural motif found in over 1000 natural products wit

111 t nuclear import of ankyrin repeats (ARs), a structural motif found in over 250 human proteins with d

112 We employed the enhanced aromatic sequon, a structural motif found in the reverse turns of some N-gl

113 Pyridine rings are common structural motifs found in a number of biologically acti

114 A variety of structural motifs found in biological composites have be

115 and gamma-lactams, both of which are common structural motifs found in drug molecules and bioactive

116 opropane-fused-delta-lactones, which are key structural motifs found in many biologically active natu

117 Cyclopropanes are important structural motifs found in numerous bioactive molecules,

118 Cyclobutanes and cyclobutenes are important structural motifs found in numerous biologically signifi

119 cyl-piperidine is a widespread and important structural motif, found in approximately 500 currently a

120 fficient and selective construction of these structural motifs from simple building blocks is desirab

121 ins to be designed by using only examples of structural motifs from unrelated proteins.

122 The reactivity and diversity of these structural motifs has captured the interest of synthetic

123 systems of design principles underlying such structural motifs has enabled the fabrication of lightwe

124 elective compounds with strikingly different structural motifs have been identified.

125 G-quadruplex (G4) structural motifs have been linked to transcription, rep

126 We showed that in T. brucei the TPR structural motifs, highly conserved between the studied

127 methodology is a powerful tool for accessing structural motifs, highly desirable by the pharmaceutica

128 pyrrolopyrimidine scaffold was modified with structural motifs identified from a screening campaign w

129 ide structures, which are based on different structural motifs, if an appropriate choice of cations i

130 Primary amines are an important structural motif in active pharmaceutical ingredients (A

131 Vicinal diamines are a common structural motif in bioactive natural products, therapeu

132 underlying mechanical roles of a ubiquitous structural motif in biogenic calcite, their nanoscopic i

133 tly well-conserved staggered cross-heme wire structural motif in functionally related outer membrane

134 The carbamate group is a key structural motif in many approved drugs and prodrugs.

135 The k-junction is a structural motif in RNA comprising a three-way helical j

136 Here, we identify a short structural motif in the disordered NS5A-D2 and report it

137 al, similar to the recently discovered MB6 M structural motif in the Ti7 Rh4 Ir2 B8 solid compound.9.

138 ssive antibody based on a novel "stalk-knob" structural motif in the ultralong complementary-determin

139 active sites and establishing links between structural motifs in a catalyst, local electronic struct

140 results shed new light on the nature of the structural motifs in ACKR2 that are responsible for liga

141 iphenylmethylamines, which are highly valued structural motifs in bioactive molecules and chemical se

142 arallels between the in vitro assemblies and structural motifs in developing enamel.

143 rategy provides opportunities to achieve new structural motifs in DNA nanotechnology and introduce ne

144 reported and compared to more commonly used structural motifs in drug discovery.

145 ive as potential electrolyte additives or as structural motifs in drug synthesis, with the latter bei

146 sheets that, on a basic level, mimic protein structural motifs in fully synthetic systems.

147 uted 5,6-dihydrophenanthridines as important structural motifs in natural products and bioactive mole

148 Nucleic acid junctions are ubiquitous structural motifs in nature and in designed materials.

149 lycyclic aromatic hydrocarbons are important structural motifs in organic chemistry, pharmaceutical c

150 Phenylacetylenes are key structural motifs in organic chemistry, which find wides

151 Well-studied structural motifs in Rad23 have been shown to bind polyu

152 2-pyridyl)-N'-ethylpiperazines are important structural motifs in several medicinally relevant compou

153 r activators via differential recognition of structural motifs in the allosteric pocket.

154 bsence of S15 revealed specific sequence and structural motifs in the central junction that are impor

155 agation of the allosteric signal through key structural motifs in the cyclic nucleotide-binding domai

156 ich we show is linked to the location of the structural motifs in the dimer interface, thereby establ

157 The mutations tested included truncations of structural motifs in the gp41 CT and two point mutations

158 Particular attention is paid to the overall structural motifs in the three-periodic cyanometallates,

159 inical development or that have revealed new structural motifs in this highly competitive area of res

160 Moreover, we identified two structural motifs in transmembrane segments 2 and 4 invo

161 ed 1,1,2-triarylethyl products that occur as structural motifs in various natural products.

162 Perhydroazulenes are common structural motifs in various terpene natural products.

163 How Plexins employ their diverse structural motifs in vivo to perform distinct roles is u

164 broad range of geminal diazides with various structural motifs including sterically demanding substit

165 isordered in isolation, p27 adopts secondary structural motifs, including an alpha-helical structure,

166 w epothilone B analogues equipped with novel structural motifs, including fluorine-containing residue

167 The conserved structural motifs investigated here shed light on the in

168 hat contains several predicted coiled-coils, structural motifs involved in protein-protein interactio

169 This structural motif is common across a range of M and X ato

170 e same, reinforcing the conclusion that this structural motif is completely general.

171 inct registers accommodated by a twist: this structural motif is exploited by vFLIP, allowing it to b

172 a spectral evolution suggests that a common structural motif is formed as early as the tetramer.

173 This structural motif is unusually consistent across all spec

174 products bearing non-native and rigidifying structural motifs, isotopic labels, and a variety of bio

175 remarkable carbon allotrope with highly rare structural motifs, it also reveals a fascinating hierarc

176 The ACT domain is a widely distributed structural motif known to be important for allosteric re

177 NAs are built from a common set of recurring structural motifs, leading to the perspective that a gen

178 nozinc compounds, leading to highly valuable structural motifs, like precursors to lignan natural pro

179 ucture shows specific interactions between a structural motif located at the end of the Rnt1p dsRNA-b

180 These data suggest structural motifs located in the two adjacent Ig-like do

181 ld of the polypeptide chain, and, typically, structural motifs made up of smaller numbers of amino ac

182 frared spectroscopy (FTIR) and tested if the structural motif matches previous data on the organic ma

183 fluorescent property of coumarin, these new structural motifs may find potential application in mate

184 tandem with two newly curated NMR molecular structural motif metabolomics databases (MSMMDBs).

185 The synergy between two structural motifs--nanoscale brick-and-mortar stacking o

186 ical materials in compounds that feature the structural motif of a square-net.

187 ic silicocenium cation and features the rare structural motif of an apical silicon(II) atom with an e

188 erein, we exploited the presence of a unique structural motif of DDX3X not shared by other cellular e

189 nstrate that the alpha-helix, a much simpler structural motif of enzyme, can facilitate its own growt

190 self-assemblies describe not only the basic structural motif of G-quadruplexes formed by, e.g., telo

191 lo[1,2-a]pyrimidine scaffold is an important structural motif of new poly(ADP-ribose) polymerase (PAR

192 robial muramyl-dipeptides (MDP), the minimal structural motif of peptidoglycan of both Gram-positive

193 te leading to the formation of an aniline, a structural motif of prospective safety concern.

194 h human breast tumors that occur in a common structural motif of RAD51.

195 subclass of aza-heterocyles as they are the structural motif of relevant cationic alkaloids, and the

196 new class of compounds that incorporated the structural motif of the 1-(3',4',5'-trimethoxtbenzoyl)-3

197 Peptidoglycan (PG) is the core structural motif of the bacterial cell wall.

198 reoselectively the cyclopentenone alkylidene structural motif of the molecule.

199 ts suggest specific druggable targets in the structural motifs of alpha-synuclein that may help preve

200 (D-A) dyes constitute one of the fundamental structural motifs of functional organic materials.

201 Here, we systematically mutagenized structural motifs of PlexB and examined the function of

202 n investigational approach, we exploited the structural motifs of the benzodiazepinic scaffold to dev

203 sing Ag concentration (0, 2, 5 at.%) but the structural motifs of the medium-range ordered clusters b

204 lly stable FeSb2 products also contain local structural motifs of the metastable phase, despite their

205 se crystal structures shed light on specific structural motifs of the S. aureus ribosome and the bind

206 cursors are determined and compared with the structural motifs of their crystalline products.

207 Our results describe important structural motifs of this channel family and lay the gro

208 pentanal (4-OPA), which has a 1,4-dicarbonyl structural motif present in many limonene SOA compounds.

209 The reactions offer potential entry to key structural motifs present in bioactive natural products.

210 addition, our work highlights how very small structural motifs present in intrinsically disordered pr

211 thesis of tetrahydrofuran diols (THF-diols), structural motifs present in many bioactive natural prod

212 In this study, we focused on structural motifs present in the core of the key immunog

213 NS5A-D2 comprises a short structural motif (PW-turn) embedded in a proline-rich se

214 Lipid-binding and lipid transfer structural motifs range from multi-beta-strand barrels,

215 stituted aromatic piperazines are privileged structural motifs recognized by aminergic G protein-coup

216 support the presence of two kink-turns, the structural motifs recognized by L7Ae, in distinct functi

217 that BP position scales systematically with structural motifs, reflecting local rigidity: disordered

218 ions is essentially governed by a few simple structural motifs, requiring only the connectivity infor

219 lactone moieties with cyclopropyl and lactam structural motifs, respectively, were found to be tolera

220 AT (PBS_HEAT) and Leucine-Rich Variant (LRV) structural motifs, respectively.

221 Thus, this study identified the structural motif responsible for the unique autophosphor

222 The structural motifs responsible for activation and regulat

223 tive phase, the presence of the rutile phase structural motif results in a faster structural collapse

224 omputational methods, we establish that this structural motif results in near optimal adsorption ener

225 We defined a minimal Rossmann-like structural motif (RLM), identified RLM-containing domain

226 For the identification of structural motif(s), first, the (1)H and (13)C chemical

227 cyclobutanes and cyclobutenes are important structural motifs seen in many bioactive natural product

228 tinct regions to interact with different DNA structural motifs, showing versatility in DNA-binding.

229 re increasingly turning to an unconventional structural motif: small, strained ring systems.

230 hway to enable concerted maturation of other structural motifs spanning multiple rRNA domains.

231 drug binding sites and have revealed unique structural motifs specific for this pathogenic strain, w

232 o- and stereocontrolled construction of this structural motif still constitutes a significant synthet

233 of new recombinant selenoproteins containing structural motifs such as selenyl-sulfhydryl and diselen

234 been that proteins with curvature-promoting structural motifs, such as wedge-like amphipathic helice

235 ules may rely on the movement of a conserved structural motif, switch II.

236 to its basic elements, which we dub tertiary structural motifs (TERMs).

237 long linear fatty acyl component, an unusual structural motif that has not been reported before in ot

238 Triazabutadienes are an understudied structural motif that have remarkable reactivity once re

239 nd regulate cellular senescence depends on a structural motif that includes tyrosine (Y)80 in the SH2

240 we highlight the concept of tessellation, a structural motif that involves periodic soft and hard el

241 ituted (tertiary) carbamyl nitrogen atoms, a structural motif that is almost inaccessible via extant

242 and suggests that granulopoiesis requires a structural motif that is conserved between the mouse Ren

243 A structural motif that is found in two cancer drugs may b

244 loop-receptor interaction represents a novel structural motif that is present in multiple structured

245 The peptide alpha-helix represents a common structural motif that mediates communication between sig

246 ory calculations (DFT), we have identified a structural motif that more effectively delocalizes elect

247 of the electronic structure, we identify key structural motifs that are associated with high water sp

248 ns of base pairs is 87% on average with many structural motifs that are highly conserved.

249 hosphonates and phosphinates are established structural motifs that are still underrepresented in tod

250 assembly of angularly substituted decalins--structural motifs that are ubiquitous in natural product

251 at the MAPK insert and C-terminal extension, structural motifs that are unique to MAPKs, play a criti

252 anding of their function and elucidating key structural motifs that can be targeted for therapeutic r

253 n architectures to create highly specialized structural motifs that can greatly enhance the rates of

254 port the conclusion that Rb evolved specific structural motifs that confer its unique capacity to bin

255 Here, we identify two structural motifs that determine the time course of AMPA

256 oromethoxy (OCF(2) H) groups are fluorinated structural motifs that exhibit unique physicochemical ch

257 assumption and to determine the fundamental structural motifs that explain Raman spectral features.

258 ved alpha-helical core, made up of ancestral structural motifs that have acted as a skeleton, might h

259 et revealed that of the various sequence and structural motifs that have been proposed to specify FMR

260 aryne intermediates for the introduction of structural motifs that have conventionally been viewed a

261 n biomedical applications and sheds light on structural motifs that make this possible.

262 entified some unique internal and peripheral structural motifs that may be potential candidates for i

263 opeptide repeat (TPR) domains are ubiquitous structural motifs that mediate protein-protein interacti

264 synthetic RNAs with particular sequence and structural motifs that permit subsequent experimental de

265 RFs have structural motifs that recognize stop codons in the deco

266 to be folded in vivo and contain a number of structural motifs that reduced accumulation of a heterol

267 ptide repeats (TPR) are well studied protein structural motifs that support intermolecular protein-pr

268 we demonstrate the existence of a recurrent structural motif, the "arginine fork", that codifies arg

269 haeal viruses, and the herpesviruses share a structural motif, the HK97 fold.

270 es of a set of variants of a common tertiary structural motif, the tetraloop/tetraloop-receptor (TL/T

271 t can be readily derivatized to more complex structural motifs through stereospecific transformations

272 ften require building blocks with particular structural motifs, thus limiting the scope of nanomateri

273 (QD), we apply the thick-shell or "giant" QD structural motif to this notoriously environmentally sen

274 n evasion mechanism by which viruses use RNA structural motifs to avoid immune restriction.

275 trofragments allowed the group efficiency of structural motifs to be assessed, the identification of

276 RNA nanotechnology uses RNA structural motifs to build nanosized architectures that

277 crystals holds promise for the design of new structural motifs to create programmable 3D DNA lattices

278 We use these structural motifs to identify novel partners of GpsB in

279 ative Poisson's ratio by using stability and structural motifs to predict new instances of homogenous

280 coarse-grained model with a set of secondary structural motifs to predict the equilibrium solution st

281 demonstrate that vPOP M013 exploits distinct structural motifs to regulate both the inflammasome and

282 rovide the first evidence that RNA can adopt structural motifs to trigger and/or maintain the specifi

283 le, M = Co(II) or Zn(II)) which have similar structural motifs to ZIFs.

284 d their narrow hydrophobic inner pores mimic structural motifs typical of biological channels.

285 of triazole-containing dipeptides having the structural motives typical of turn inducers.

286 satile approach to stabilize diverse protein structural motifs under a range of chemical environments

287 nce differences result in markedly different structural motifs upon physiological twisting and stretc

288 The HK97 fold is a structural motif used to form the coat protein shells th

289 The attachment of the aziridine structural motif was achieved by application of the Ess-

290 The desired structural motif was formed in moderate to excellent yie

291 The desired structural motif was formed in moderate to good yields (

292 ta Bank led to identification of a recurring structural motif where lysine NH3(+) group interacts wit

293 dentified a (S,S)-cyclopropylcarboxylic acid structural motif which gave selectivity against GPR40.

294 tion between critical residues and important structural motifs which undergo reorganization during ma

295 e majority shares a rather limited number of structural motifs, which are defined by sets of (1)H and

296 t the coordination number of network-forming structural motifs, which play a key role in defining the

297 II)(5)(CN)(13) forms a complex, 3-D extended structural motif with octahedral and rarely observed squ

298 alation region is a new type of DNA tertiary structural motif with similarities to the i-motif.

299 rare codon clusters separate smaller protein structural motifs within structural domains.

300 w that pathogenic alphaviruses use secondary structural motifs within the 5' untranslated region (UTR