ライフサイエンスコーパス: structurally

1 onserved among IgLONs but remarkably plastic structurally.

2 ve been characterized both biochemically and structurally.

3 n vivo would cause an irreversible loss of a structurally aberrant enzyme through proteolytic degrada

4 Proteolytic degradation of a structurally aberrant enzyme would explain the superior

5 The mitral valve is often structurally abnormal in hypertrophic cardiomyopathy (HC

6 ch revealed that miRNA target sites were not structurally accessible for miRISC binding prior to clea

7 omolecular input, transform the input into a structurally accessible form for circuit wiring, transla

8 nt that this common mechanistic principle is structurally adjusted to carry out a diverse array of bi

9 t remains unclear how binding and hydrolysis structurally alters the SL receptor to enable its engage

10 on, versus the allosteric mechanisms seen in structurally analogous class A G protein-coupled recepto

11 The structurally analogous mu-silyl- and mu-borylamide compl

12 eir ability to generalize learned rules to a structurally analogous new language.

13 We structurally analyzed Bacillus subtilis RNAP-delta-HelD

14 Members of clades 1-3 have been structurally and biochemically characterized, but the fo

15 The actin cytoskeleton consists of structurally and biochemically different actin filament

16 t as a functionality-changing switch for two structurally and biochemically similar signaling molecul

17 ults showed that magnetosomes are stable and structurally and chemically unaffected at temperatures u

18 nsitional region differentially constrict to structurally and dynamically determine the morphology of

19 of the circuits into which the cancer cells structurally and electrically integrate.

20 The reactions employ two structurally and electronically very different in situ s

21 and the arthropod mushroom bodies, are both structurally and functionally comparable.

22 nigra (SNc)-related nigrostriatal pathway is structurally and functionally connected with core region

23 Hippo pathway components are structurally and functionally conserved and are notable

24 n the present study, BrdU-dated cells of the structurally and functionally dissociated dorsal (dDG) a

25 and its single-step transformation into two structurally and functionally distinct types of macrocyc

26 Several structurally and functionally diverse proteins have been

27 The intraparietal sulcus (IPS) is structurally and functionally heterogeneous.

28 The 35 kDa OCP is structurally and functionally modular, consisting of an

29 , the stomach and colon were associated with structurally and functionally more diverse and variable

30 The cell envelope structurally and functionally varies across the length o

31 The ability to produce structurally and functionally well-defined transmembrane

32 odern protein synthetic chemistry to develop structurally and new families of tool molecules needed f

33 , but its application in efforts to identify structurally and physicochemically often dissimilar micr

34 )](2+) (1), is synthesized and characterized structurally and spectroscopically.

35 e show the usefulness of our approach on 759 structurally and therapeutically diverse drugs and 994 s

36 -closed conformation and show antigenically, structurally, and immunogenically that combining 3mut wi

37 R) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeuti

38 These structurally annotated CDRs provide unprecedented insigh

39 s point to dual functions of histidine-43 in structurally assisting the proper coupling between K1 an

40 Structurally, beta-secretase has a very large binding si

41 used DNA-encoded chemical libraries that are structurally biased for a class of protein targets.

42 ues of apatite are generally higher than the structurally bound Cl, and ubiquitously higher than the

43 topes (delta(17)O, delta(18)O and deltaD) of structurally-bound gypsum (CaSO(4).2H(2)O) hydration wat

44 Recombinant Env trimers have been studied structurally, but characterization of Env embedded in in

45 , 2As; P, 2P), where 2As is an unprecedented structurally characterised arsonium-carbene complex.

46 is a protein footprinting technique used to structurally characterize proteins.

47 We have used novel rapid methods to structurally characterize the complementary-determining

48 Here, we biochemically and structurally characterize the naturally split intein Vid

49 tathesis has been used to generate the first structurally characterized boryl complexes of calcium an

50 ge group were generated in the gas phase and structurally characterized by tandem mass spectrometry,

51 2 was structurally characterized by X-ray crystallography, sho

52 ing the reaction, two of which have now been structurally characterized by X-ray crystallography.

53 he benchmark compound ROY as single crystals structurally characterized by X-ray diffraction.

54 Here we have prepared and structurally characterized diatomic C(2) as a monoligate

55 Here, we biochemically and structurally characterized diverse inhibitors with varyi

56 magnet research that laid the foundation for structurally characterized metal-organic framework magne

57 identified the metal atoms in 30 previously structurally characterized proteins using minimal sample

58 Amicetin, however, is the first compound structurally characterized to bind to the P-site with de

59 d-state events on the ps timescale have been structurally characterized, conformational changes on sl

60 frameworks (COFs) have been synthesized and structurally characterized.

61 , and pleckstrin domain (DEP1) remains to be structurally characterized.

62 ide was isolated from ripe tomato fruits and structurally characterized.

63 (ZnMe)(2)][BAr(F)(4)] (6) can be trapped and structurally characterized.

64 ediates of the reaction were synthesized and structurally characterized.

65 While it is well understood that, structurally, cholesterol exhibits a densification effec

66 Structurally, chrysophaentin A features a macrocyclic bi

67 ent to shift the protein population toward a structurally closed structure of the complex.

68 Here, we show that although structurally clustered mutations in SNAP25 give rise to

69 logics, including monoclonal antibodies, are structurally complex and are unable to penetrate the ski

70 The synthesis of structurally complex and highly strained natural product

71 larger than D. melanogaster and exhibit more structurally complex antennal lobes [7-12].

72 Epithiodiketopiperazines (ETPs) are a structurally complex class of fungal natural products wi

73 From simple starting materials, structurally complex cyclopentenones may be rapidly asse

74 Forests and coral reefs are structurally complex ecosystems threatened by climate ch

75 Structurally complex habitats tend to contain more speci

76 ctional group interconversions to access the structurally complex linker-attached trisaccharide repea

77 oes this process provide characterization of structurally complex molecules, it works as a reader of

78 gy landscapes at high resolution, studies of structurally complex multidomain proteins, folding in th

79 tandard approach for the characterization of structurally complex nanoparticle populations, as it yie

80 ition from linear DNA structures toward more structurally complex nanostructures has revolutionized l

81 nematodes produce an impressive diversity of structurally complex NDMMs, some of which act as primer

82 ing the utility of this method for accessing structurally complex products from simple starting mater

83 demonstrated by the borylation of a range of structurally complex substrates.

84 n-and explains 98% of surface variation in a structurally complex test system: coral reefs.

85 ew insights into phosphorus as well as other structurally complex, e.g., layered solids that are rele

86 lic) RNA class is among the largest and most structurally complex.

87 combining an external stimulus applied to a structurally compliant adsorbent, offers a promising ave

88 tional steady-state localization showed that structurally compromised KOR1 variants were directed to

89 restrial protected network can be considered structurally connected.

90 ations in the NHL domain are molecularly and structurally conserved between fly and human TRIM32.

91 y in Arabidopsis uL18 proteins share a short structurally conserved domain that binds the 5S ribosoma

92 The PPR domain of PRORP1 bound to the structurally conserved elbow of tRNA and recognized cons

93 ed a novel fusion-modulatory role of a third structurally conserved helical region (HR3) in F.

94 Cyclophilins are structurally conserved pan-allergens showing extensive c

95 econstituted into nanodiscs, including those structurally constrained in the cytoplasm-facing state a

96 ibody-siRNA (1:2) conjugates (ARCs) that are structurally defined and easy to assemble.

97 Microarray and SPR assays of structurally defined HS oligosaccharides show that a rar

98 Structurally defined mimics of native trimeric Env glyco

99 modes of action requires the availability of structurally defined paCOS that can best be produced usi

100 nd the epitope recognized by h5B3.1 has been structurally defined; however, the efficacy of h5B3.1 in

101 In this study, a structurally-defined human monoclonal alloantibody was e

102 Structurally different alkenes, along with an alkyne, ha

103 A wide range of structurally different substrates, viz., cyclohexane, cy

104 Herein, we disclose three structurally differentiated gamma-secretase modulators (

105 city signatures were identified arising from structurally dissimilar PFAS.

106 both proteins, resulting in the formation of structurally distinct aggregates.

107 Mechanistically, macroH2A1.2 counteracts its structurally distinct and equally Xi-enriched alternativ

108 Darolutamide is a structurally distinct androgen-receptor inhibitor that i

109 antibiotic arsenal through the discovery of structurally distinct antibacterial molecules.

110 CG2 in the apo state, and bound to the three structurally distinct chemotherapeutics.

111 of BMN proteins respectively defined by two structurally distinct classes of extracellular domains.

112 antiferroelectric state, with inclusions of structurally distinct ferrielectric domains enclosed by

113 We recently showed that structurally distinct fibrillar alpha-Syn polymorphs tri

114 he enzymes that catalyze these reactions are structurally distinct from ubiquitous terpene cyclases t

115 ified the diffusion properties of a panel of structurally distinct lipid, lipid-anchored, and transme

116 sistant cells showed cross-resistance to the structurally distinct MEKi trametinib and elevated extra

117 We found that several structurally distinct PARPi drive PARP-1 allostery to pr

118 The TCRs employ structurally distinct strategies that are highly focused

119 Structurally distinct T(H)2-polarizing agonists varied i

120 catenanes is due to a spontaneous stereo and structurally divergent assembly of the building blocks.

121 MC4R is revealed as a structurally divergent G protein-coupled receptor (GPCR)

122 Structurally Divergent Reactions on Racemic Mixtures are

123 the ligand-binding site and make up the most structurally divergent regions in cognate Nod factor rec

124 experimentally determined half-lives for 52 structurally diverse agrochemical active ingredients in

125 A series of structurally diverse alcoholamine- and alkoxyalkylamine-

126 st family members, LASP1 and LASP2, are more structurally diverse and are expressed in a broader arra

127 logy was developed for expeditious access to structurally diverse and complex pyrazole-pyrazines in o

128 played by heparin by allowing the longer and structurally diverse chains to interact with the client

129 eveloped for the regioselective synthesis of structurally diverse chromenopyrrole frameworks from 3-f

130 Lipids are a structurally diverse class of molecules with important b

131 Pomegranate juice is a complex mixture of structurally diverse compounds appearing in various conc

132 h it functions as a low-threshold sensor for structurally diverse electrophilic irritants, including

133 Cobalamin riboswitches encompass a structurally diverse group of cis-acting, gene regulator

134 dearomatized acylphloroglucinols to access a structurally diverse group of synthetic acylphloroglucin

135 Here we report an array of structurally diverse hybrid ruthenium halide perovskites

136 eS25), which is required by functionally and structurally diverse IRESs, impacts both steps of the co

137 el membranes show common properties of these structurally diverse lipids that also share a known func

138 Sphingolipids (SLs) are structurally diverse lipids that are defined by the pres

139 ndent NR repression appears to occur through structurally diverse mechanisms.

140 rved oxindole isostere, shared between three structurally diverse modulators (LY-3130481, JNJ-5551111

141 building blocks, and their transformation to structurally diverse molecular scaffolds.

142 of methods, applied to a large corpus of 550 structurally diverse networks from six scientific domain

143 Structurally diverse orthosteric and allosteric ligands,

144 ns Fis and HU and by Nhp6A, indicating these structurally diverse proteins impede Nhp6A mobility on D

145 We explored here the oligomerization of a structurally diverse set of prebiotically plausible xeno

146 olchicine site binders, a frequent target of structurally diverse small molecules.

147 target validation of this class of proteins, structurally diverse small-molecule ligands and methodol

148 tically and spatially restricted, as well as structurally diverse specialized metabolites via multist

149 Heparan sulfates are structurally diverse sulfated polysaccharides that resid

150 Structurally diverse wall teichoic acids (WTAs), which c

151 on molecules that would be easy to make, yet structurally diverse.

152 This enables the analysis of structurally driven polyspecificity in TCRs, which is no

153 The d(CGA) triplet repeat motif is structurally dynamic and can transition between parallel

154 experiments confirm that the +3 RTIC is more structurally dynamic than earlier-stage RTICs.

155 of zearalenone and its metabolites have been structurally explained.

156 the force produced by posttetanic twitches, structurally explaining posttetanic potentiation.

157 In Escherichia coli, the CTT contains a structurally flexible linker domain and a small metal-bi

158 Expanded helicenes are large, structurally flexible pai-frameworks that can be viewed

159 The heterogeneous hydrogels can be structurally fused by interfacial crosslinking and coupl

160 Structurally, geniculate axons innervated excitatory cor

161 te the dissemination patterns of MDSCs under structurally guided migration, at the single-cell level.

162 Structurally, H(2)O(2) treatment reduced the number of c

163 occus radiodurans phytochrome changes from a structurally heterogeneous dark state to an ordered, lig

164 obtained for PF4 association with longer and structurally heterogeneous heparin oligomers (decamers).

165 The structurally heterogeneous peri-infarct zone is a known

166 rmolecular contacts and was otherwise highly structurally heterogeneous.

167 sparate and often anomalous properties, from structurally homogeneous mixed valency, to superconducti

168 wo subunits, GABA(B1) and GABA(B2), that are structurally homologous but perform distinct and complem

169 The structurally homologous Mtf1 and TFB2M proteins serve as

170 Furthermore, dbToxRp is structurally homologous to the V. parahaemolyticus VtrA

171 c insight into such heteromerization using a structurally homologue apolipoprotein fragment of apoA-I

172 K95 and pneumococcal strain D39 both produce structurally identical capsular PS, and their genetic ba

173 ariant with an impaired MIDAS (but otherwise structurally identical) by small-angle X-ray scattering

174 t understood of these channels, with various structurally identified features within its trimeric ass

175 their embryos, and eight modifications were structurally identified using high-resolution accurate m

176 the importance of maintaining and enhancing structurally intact forests.

177 We conclude that NMJs remain structurally intact in rectus abdominis in both cancer a

178 nes to construct electrically conductive and structurally intact Pe-QD solids for efficient optoelect

179 s associate in supercomplexes (SCs) that are structurally interdependent.

180 abicyclo[3.2.0]heptan-2-one motif, which are structurally interesting cores with potential in natural

181 A structurally intriguing exception to all known transmemb

182 ntioselective synthesis of (-)-maximiscin, a structurally intriguing metabolite of mixed biosynthetic

183 e available, including some enantiomeric and structurally isomeric forms.

184 a suspect-screening approach, including 700 structurally known cyanopeptides, and identified 11 cyan

185 ucing a neuroprotective cis interaction that structurally links the protein's two domains.

186 GCP6 form distinct Y-shaped assemblies that structurally mimic GCP2/GCP3 subcomplexes distal to the

187 These molecules, named KoH bodies, structurally mimic naturally existing Bence-Jones light-

188 -a human des-octapeptide insulin analog-as a structurally minimal, full-potency insulin.

189 from CIU suggest that Ag(i)-MT complexes are structurally more ordered and that the energy required t

190 fully functional Cu(A) center designed in a structurally nonhomologous protein, cytochrome c peroxid

191 lmos is a rare condition defined by a small, structurally normal eye with resultant high hyperopia.

192 been extensively studied in patients with a structurally normal heart, these are less well understoo

193 stes that are germline ablated but otherwise structurally normal.

194 structural classes of antibiotics are rare, structurally novel broad-spectrum antibiotics exceptiona

195 applies SMART 2.0 to the characterization of structurally novel cyclic peptides, and compares this ap

196 Here, we show that a structurally novel form of the heterocyst, the specializ

197 omy of these structures and the absence of a structurally observable inverse trans-influence in 2-U(P

198 ed a multivalent, polymer-based prodrug of a structurally optimized camptothecin (SN22) designed to o

199 interactions have been better characterized structurally or by simulations than experimentally in wa

200 ilament protein lacks detectable homology to structurally or functionally characterized proteins.

201 structural features and rich functionality, structurally ordered covalent organic frameworks (COFs)

202 ze around the protein's small protrusions in structurally ordered waters that are characteristic of t

203 can extract water of crystallization (i.e., structurally ordered) from the rock, inducing a phase tr

204 neous and homogeneous characteristics with a structurally organized active "solid-like" catalyst sepa

205 class of phase transformation that occurs in structurally organized, molecularly crowded, and dimensi

206 Structurally, phi14:2 RNAP is most similar to eukaryotic

207 h other as homomers and heteromers, they are structurally plastic and can exert unique biological act

208 sponsive 1D and 2D assemblies that undergo a structurally programmed morphological transition.

209 ed weak agonism on FXR and PPARdelta and was structurally refined to a potent and balanced FXR/PPARde

210 howcase studies, the design and synthesis of structurally regular series of SACs opens the door to sy

211 Because proteins that are structurally regulated by different RTKs or cellular per

212 anced inhibition selectivity relative to the structurally related aldehyde reductase was recorded.

213 Kratom produces more than 40 structurally related alkaloids, but most studies have fo

214 it for the sequencing of heparan sulfate and structurally related biomolecules.

215 ental and computational analysis of Bpin and structurally related boronic esters which allows determi

216 e results did not significantly improve with structurally related catalysts, and a totally unexpected

217 fers from the canonical PTE but falls into a structurally related class of 3' CITEs.IMPORTANCE In the

218 trategy is useful for the synthesis of other structurally related complex glycans.

219 parison of this data with those reported for structurally related compounds, and based on their commo

220 /trans isomers that can discriminate between structurally related enzyme isoforms.

221 we postulate that it is common for all these structurally related enzymes.

222 Work here identifies structurally related furan compounds as novel inhibitors

223 IL-23 and IL-12, two structurally related heterodimeric cytokines sharing a c

224 A structurally related material, K(16.3)Ir(8)O(30), which

225 al pH and temperature and did not respond to structurally related molecules acetate and beta-hydroxyb

226 vity of C. burnetii to progesterone, but not structurally related molecules, is consistent with the a

227 e deficit spending mechanism observed in the structurally related nitrogenase complex.

228 RNase P and RMRP, two sequence-divergent but structurally related non-coding RNAs, share RNP networks

229 (DNA-PKcs) with good selectivity versus the structurally related PI3 (lipid) and PI3K-related protei

230 sts with benzhydrylium ions (Ar(2)CH(+)) and structurally related quinone methides, common reference

231 BACE2, an aspartyl protease that is structurally related to BACE1, has been recently reporte

232 (MCs) belong to a cysteine protease family, structurally related to metazoan caspases.

233 Butyrophilin-3A1 (BTN3A1), a protein structurally related to the B7 family of costimulatory m

234 This compound is structurally related to the Food and Drug Administration

235 7 and lipid 342, and these lipid classes are structurally related to the serine-glycine dipeptide lip

236 b-AP15 and VLX1570 are two structurally related USP14/UCH-37 inhibitors.

237 of the 80S-like assembly intermediate, which structurally resembles scanning complexes, requires the

238 analysis to infer that the transition state structurally resembles the inward-facing conformation.

239 oiety is the active antimicrobial component, structurally resembling a hybrid between ceftazidime and

240 AncFMO1 crystallized as a dimer and was structurally resolved at 3.0 angstrom resolution.

241 Therefore, this study has structurally revealed that the niche is organized into m

242 The RNA-paclitaxel complex is structurally rigid and stable, demonstrated by the sub-n

243 tured on Matrix Plus mature functionally and structurally seven days after thaw from cryopreservation

244 gmentation pathways to generate informative, structurally significant product ions.

245 and post-translationallycleaved Ara h 6 are structurally similar and theirstrong resistance to denat

246 Conversely, Y155 mutation to a structurally similar but non-phosphorylatable amino acid

247 ibitors of BlaR1/MecR1 sensor domains or the structurally similar class D beta-lactamases.

248 We also developed two structurally similar control compounds, 5 (MS167) and 7

249 By contrast, electronically and structurally similar EDO ligands such as dimethyl fumara

250 More specifically, quantification via structurally similar internal standards, different isoto

251 de that PIP(2) influences GIRK channels in a structurally similar manner to Kir2.2 channels.

252 For comparison, the structurally similar Ni compound, [Ni(Htrz)(3)](n)[ClO(4

253 g protein-DNA interaction information across structurally similar proteins is a powerful means to ena

254 plex proteins, DotC, DotD, and DotH, and two structurally similar proteins within the core complex, D

255 onents (Cag3 and CagM) and show that Cag3 is structurally similar to CagT.

256 rate polymerase fold and a C-terminal domain structurally similar to Cas11.

257 ns a Zn(2+) ion at its active center, and is structurally similar to characterized enzymes that confe

258 furantoin, a known antibiotic that, although structurally similar to ES24, does not interfere with Se

259 evealed that the N-terminal half of LegK7 is structurally similar to eukaryotic protein kinases, and

260 ed via an in vitro amyloidogenic pathway are structurally similar to ex vivo human amyloid fibrils do

261 ere abundant in the nightingale song and are structurally similar to fusion rhythms (ornaments) in mu

262 We found that Diadema bindin is structurally similar to that of other genera, but much l

263 lin and butyrophilin-like molecules that are structurally similar to the immunosuppressive B7 family

264 At first, 10,184 molecules structurally similar to the known sweeteners were identi

265 the OG:A mispair amidst highly abundant and structurally similar undamaged DNA base pairs.

266 in with distinct SAM domains predicted to be structurally similar.

267 tion and reorganization, whereas aggrecan, a structurally-similar large PG, has different and often o

268 Here, we report a structurally simple and easily accessible l-proline deri

269 Here, we studied the encapsulation of three structurally simple BODIPY derivatives within the hydrop

270 ults create new possibilities for generating structurally sophisticated out-of-equilibrium species.

271 h a clay layer and the repeated failure of a structurally sound community well.

272 The 3-DXA remained structurally stable to MAE conditions up to 1200 W/100 d

273 t that the designed multi-epitope vaccine is structurally stable which can induce specific immune res

274 denine complexes from the Protein Data Bank, structurally superimposes their adenine fragments, and d

275 First structurally, the presence of MCF led to an initial incr

276 have been largely described functionally and structurally, the stoichiometry and arrangement of heter

277 d with reorganization of further amino acids structurally transforming a loop adjacent to the recogni

278 The present study sheds light on structurally unexplored copper nanomaterials and paves t

279 nosine) representing epigenetic marks, and a structurally unidentified nucleoside adduct.

280 radical framework reconstruction approach to structurally unique 13(14 -> 8),14(8 -> 7)diabeo-steroid

281 These pathogens express structurally unique and densely functionalized glycans o

282 ssays resulted in the identification of five structurally unique and selective HCMV inhibitors, activ

283 taining proteins and use it to design 75,000 structurally unique junctions between monomeric and homo

284 The EDS1 family of structurally unique lipase-like proteins EDS1, SAG101, a

285 Apramycin is a structurally unique member of the 2-deoxystreptamine cla

286 ork illustrates the antifungal activity of a structurally unique NCR peptide against plant fungal pat

287 differences and their respective role in the structurally unique pseudo-heterodimer PfCCT protein in

288 of SARS-CoV have revealed that it employs a structurally unique three-stemmed mRNA pseudoknot that s

289 confer drug resistance on cells by extruding structurally unrelated compounds from the cellular inter

290 tic proteins that bind methylated RNA and is structurally unrelated to the E. coli McrB DNA-binding d

291 families and represent novel hMC1R agonists, structurally unrelated to the natural agonists.

292 3-binding site (site 1) within the flexible, structurally unresolved N-terminal APN region using dire

293 The disease variants lead to structurally unstable MCAT protein with significantly re

294 ydrazine adduct can be further oxidized to a structurally unusual Ni(2) (N(2) H(2) ) species; this re

295 The underlying mechanism is structurally unusual, with the loss of part of the alpha

296 Terpenes constitute one of the most structurally varied classes of natural products.

297 (abc) domain has previously been found to be structurally very similar to the GAT domain present in G

298 by designing a competitive inhibitor that is structurally very similar to the native substrate, resul

299 out of equilibrium have, to this point, been structurally very simple.

300 A new family of structurally well-defined molybdenum alkylidyne catalyst