ライフサイエンスコーパス: study uncover

1 spective, double-blind, multicentre, phase 3 studies (UNCOVER-2 and UNCOVER-3), eligible patients wer

2 Sequencing studies uncovered 212 potential biological targets invol

3 These studies uncover a fine-tuned modulation of the proto-onc

4 Our studies uncover a linear signaling pathway from HRI to A

5 Thus, our studies uncover a link of FOXO1, ER stress and HIV infec

6 Collectively, our studies uncover a mechanism by which BAF155 acquires tum

7 These studies uncover a mode of epithelial closure in which fo

8 Genetic studies uncover a mutation in a widely conserved protein

9 Flagellin is shed from bacteria and our studies uncover a new bystander role for this protein in

10 Two new studies uncover a new facet of its regulation in epithel

11 Our studies uncover a new function for polyadenylation in co

12 Taken together, our studies uncover a new metastasis-promoting pathway in Ew

13 Our studies uncover a novel link between MLH1, telomerase, t

14 These studies uncover a novel mechanism by which stress sensin

15 These studies uncover a novel mechanism for the anti-diabetic

16 Our studies uncover a novel mechanism through which the diox

17 Our studies uncover a novel role of the tubular beta-catenin

18 These studies uncover a p53-Ptpn14-Yap pathway that is integra

19 Collectively, these studies uncover a pathogenic role for alternative TDP43

20 These studies uncover a possible mechanism by which local inna

21 Taken together, our studies uncover a previously unidentified role for Hh as

22 These studies uncover a previously unrecognized function for K

23 Our studies uncover a previously unsuspected role of pDCs in

24 These studies uncover a rate-limiting ET within the solvent-fi

25 These studies uncover a role for miR-148a as a key regulator o

26 These studies uncover a role for PGRMC2 in intracellular haem

27 Recent structural and biophysical studies uncover a role for the opening or rotating of th

28 These studies uncover a role for vigilin as a key regulator of

29 These studies uncover a speed control mechanism that might all

30 These studies uncover a transcriptional feedback loop for becl

31 Genome-wide association studies uncovered a major atrial fibrillation susceptibi

32 oint analyses as well as electron microscopy studies uncovered a role for B1 during maturation of pox

33 Our studies uncovered a Wnt5a-Ror2-Vangl2 cascade that endow

34 The findings of our study uncover a cellular intrinsic mechanism involving t

35 The findings of our study uncover a mechanism by which PARN acetylation and

36 The results of the present study uncover a new function for an olfactory bulb neuro

37 This study uncovered a cell-intrinsic mechanism by which HCV

38 Thus, our study uncovered a complex relationship between TORC1 ina

39 Our study uncovered a critical molecular crosstalk between T

40 This study uncovered a distinct mechanism regulating de novo

41 Taken together, our study uncovered a mechanism that EV71 utilizes to promot

42 This study uncovered a new function of Cdc6 in regulating cel

43 Thus, our study uncovered a new role for APX6, in protecting matur

44 Our study uncovered a novel carrier-mediated pathway for dru

45 Collectively, our study uncovered a novel mechanism by which AtPRMT3 coope

46 Thus, our study uncovered a novel metabolic function of hepatic BM

47 Taken together, the findings from this study uncovered a novel role of Kv11.1 channels in lung

48 The present study uncovered a previously unappreciated capability of

49 Together, our study uncovered a previously unknown molecular mechanism

50 This study uncovered a role for ARF3 in FM determinacy and re

51 Our previous study uncovered a unique consequence of hybridization in

52 This study uncovers a BTLA-mediated strategy used by the host

53 A new study uncovers a central role for microtubule motor-regu

54 Our study uncovers a connection between transcription and ch

55 Our study uncovers a critical mechanism of immunosuppression

56 Our study uncovers a critical role for Ape1 in DNA repair pa

57 Hence, this study uncovers a critical role for MYSM1 in epigenetical

58 This study uncovers a dual role for Vps34 as a regulator of p

59 Our study uncovers a flexible non-uniform fitness mechanism

60 Our study uncovers a function of SRC in cell-cell communicat

61 Our study uncovers a functional role for the endocannabinoid

62 This study uncovers a fundamental role for the skeletal muscl

63 Our study uncovers a hierarchical, SLM2-dependent mechanism

64 This study uncovers a historic role of wild Solanum species i

65 This study uncovers a hitherto uncharacterized consequence of

66 Hence, our study uncovers a JNK-Hh-JAK-STAT signaling axis in the r

67 This study uncovers a layer of quality control of HR relying

68 Our study uncovers a local crosstalk between mast cells and

69 Thus, our study uncovers a local repulsive mechanism required for

70 Together, our study uncovers a master regulator of the cholesterol-bio

71 This study uncovers a mechanism by which Hof1 controls timely

72 Overall, this study uncovers a mechanism by which oncogenic RAS preser

73 Our study uncovers a mechanism for cocaine that bypasses DA

74 This study uncovers a mechanism for integrating environmental

75 This study uncovers a mechanism for shaping NAc core activity

76 Taken together, our study uncovers a mechanism of azole resistance in C. alb

77 Our study uncovers a mechanism that links the remodeling of

78 Our study uncovers a mechanism whereby co-existing cytoplasm

79 Together, this study uncovers a mechanism whereby serum mitogen signali

80 This study uncovers a molecular cross talk between WNT/beta-c

81 Our study uncovers a molecular mechanism for vitamin D defic

82 This study uncovers a new function for IRF5 in controlling th

83 Our study uncovers a new mechanism for BAP1 involved in deub

84 Our study uncovers a new mechanism of action for DISC1 based

85 Our study uncovers a new mechanism of nuclear quality contro

86 Our study uncovers a new pathway that controls synaptic APP

87 Our study uncovers a new regulatory pathway involving miR-19

88 Our study uncovers a new role for Gravin in coordinating gam

89 Our study uncovers a new role of mechanical tension in neura

90 This study uncovers a new signal crosstalk between endocrine

91 Altogether, this study uncovers a noncanonical function of MPO enzyme in

92 Our study uncovers a noncanonical thermogenic mechanism thro

93 Overall, our study uncovers a novel ability of TIM-family proteins to

94 Altogether, our study uncovers a novel and essential role for the transc

95 Our study uncovers a novel aspect of endothelial cell migrat

96 This study uncovers a novel class of dual inhibitors of DUBs

97 Our study uncovers a novel cross-talk between LGR5 and TGFbe

98 This study uncovers a novel epigenetic RNAi-based epimutation

99 This study uncovers a novel function for MDSCs to inhibit B l

100 Our study uncovers a novel function of AMPKalpha1 in redox r

101 Collectively, our study uncovers a novel function of NLRP3 by demonstratin

102 Our study uncovers a novel function of TNKS in the relief of

103 Therefore, this study uncovers a novel mechanism of action of indenoisoq

104 This study uncovers a novel mechanism of nitric oxide product

105 Our study uncovers a novel mechanism of somatic cell differe

106 This study uncovers a novel mechanism regulating polarized pr

107 Our study uncovers a novel mechanism whereby phosphorylation

108 This study uncovers a novel mechanochemical connection betwee

109 Our study uncovers a novel molecular mechanism by which AEG-

110 Our study uncovers a novel molecular mechanism for regulatin

111 Thus, our study uncovers a novel regulatory mechanism for the deve

112 Collectively, our study uncovers a novel regulatory mechanism mediating bo

113 Our study uncovers a novel role of Bcl2 in HSC quiescence re

114 Collectively, our study uncovers a novel role of HS-type glycosaminoglycan

115 Together, our study uncovers a novel signaling circuit functioning to

116 Our study uncovers a novel tumor suppressor role of ZBTB7A i

117 Our study uncovers a pathogenic role for IFN-alpha/-beta in

118 Our study uncovers a PML degradation mechanism through Notch

119 Thus, our study uncovers a possible link between a protein require

120 5 is safe and well tolerated in humans, this study uncovers a potential therapeutic approach for HF a

121 Our study uncovers a premeiotic role for an invertebrate bou

122 Collectively, our study uncovers a previously unappreciated role of PML in

123 Together, this study uncovers a previously uncharacterized histone deac

124 Our study uncovers a previously undefined role of innate leu

125 This study uncovers a previously underappreciated dependency

126 Our study uncovers a previously unknown mechanism by which a

127 Our study uncovers a previously unknown mechanism by which G

128 Our study uncovers a previously unknown mechanism for the in

129 In sum, our study uncovers a previously unknown mechanism in which R

130 Our study uncovers a previously unknown relationship between

131 Our study uncovers a previously unknown relationship between

132 This study uncovers a previously unknown role for acyl-carnit

133 Thus, this study uncovers a previously unknown role of MT6/MMP25 in

134 Collectively, our study uncovers a previously unknown tightly coupled posi

135 This study uncovers a previously unrecognized dominant functi

136 Our study uncovers a previously unrecognized mechanism by wh

137 Collectively, our study uncovers a protective role for OVOL1 in curtailing

138 Collectively, our study uncovers a protein complex, which consists of FIGN

139 Collectively, our study uncovers a protein complex, which consists of SWS1

140 posure therapies.SIGNIFICANCE STATEMENT This study uncovers a reciprocal relationship between dendrit

141 Our field and laboratory study uncovers a rich sexual repertoire that predictably

142 Our study uncovers a role for GUN1 in the regulation of RNA-

143 This study uncovers a role of HEY2 in the normal transmural e

144 Taken together, our study uncovers a role of TTP as a suppressor of feedback

145 Altogether, this study uncovers a significant mechanism for defective cho

146 Our study uncovers a strategy used by L. monocytogenes to mo

147 Overall, this study uncovers a strong connection between chromatin re-

148 Together, our study uncovers a TET1/GFI1/EZH2/SIN3A/miR-22/CREB-MYC si

149 Our study uncovers a unique antibacterial role for HMOs agai

150 Together, this study uncovers a unique molecular mechanism of lymphangi

151 Altogether, our studies uncover an essential role for DNMT1 in MaSC and

152 he flight muscle phenotype in Drosophila Our studies uncover an evolutionarily ancient role for SRF i

153 Furthermore, our studies uncover an important role of MRN, CtIP, and thei

154 Our studies uncover an indispensable role of APP in the GABA

155 Thus, our mechanistic studies uncover an NBAT1-dependent CRM1/MDM2-based poten

156 These studies uncover an RNA-mediated mechanism of targeting A

157 The results of this study uncover an intriguing beneficial interaction betwe

158 Together, our study uncovered an association of sporadic Q331K mutatio

159 Our study uncovered an evolutionarily conserved recruitment

160 Our study uncovered an important role of SHP2 in bone develo

161 This study uncovers an anti-sense lncRNA (APOA4-AS), which is

162 This study uncovers an association of male fertility with dev

163 This study uncovers an essential role for ANKS4B in brush bor

164 Our study uncovers an essential role for FA proteins in main

165 Together, our study uncovers an essential role for SDE2 in maintaining

166 Furthermore, our study uncovers an important contribution of the non-kina

167 Therefore, this study uncovers an important role for TLX and miR-219 in

168 Our study uncovers an inf-DC-gammadeltaT17-PMN-MDSC regulato

169 Collectively, our study uncovers an integrin alpha11-positive subset of pr

170 Our study uncovers an intricate IBC-initiated autocrine-para

171 Therefore, our study uncovers an oncogenic role of EZH2 independent of

172 Our study uncovers an unexpected mechanism of therapeutic in

173 Thus, our study uncovers an unforeseen role of CaN in postsynaptic

174 Our study uncovers an unrecognized higher-order-translation

175 This study uncovers and investigates the effect of phosphatid

176 Taken together, these studies uncover ANK3 and other genes in our dataset as b

177 Thus, our study uncovers biophysical gradients in the cerebellar c

178 Collectively, our study uncovers both separate and interdependent Brd2 and

179 Collectively, our studies uncover causal mechanisms for the class II pheno

180 A molecular network map revealed in this study uncovers CD271 as a context-specific molecular swi

181 risons become apparent using gar: functional studies uncovered conserved roles for such cryptic CNEs,

182 Together, these studies uncover critical roles for NFIA in reactive astr

183 Our study uncovered critical effects of SRSF2 mutants in hem

184 This study uncovers critical redox control of tumor plasticit

185 Together, our study uncovers critical roles of the actin bundler T-Pla

186 Further studies uncovered defects related to MAP kinase I (Slt2)

187 Our studies uncover design similarities between LCD and deve

188 This study uncovered differences in the fatty acid selectivit

189 Our study uncovers differential and context-dependent effect

190 Mechanistic studies uncovered distinct catalytic activities and reac

191 Our study uncovers early mesenchymal-neuroepithelial interac

192 Our study uncovers essential mechanistic insights to the neu

193 Our study uncovers essential roles of Afadin and RhoA in pan

194 This study uncovers ETV4 as an important factor in controllin

195 Together, our study uncovers evolutionarily important determinants of

196 Our study uncovered extensive networks of peptidergic signal

197 Taken together, our study uncovers, for the first time, that RECK is a novel

198 Our study uncovers genes required for lineage specification

199 Genetical genomics studies uncover genome-wide genetic interactions between

200 Therefore, our study uncovers GRKs as targets for ameliorating patholog

201 Genetic studies uncovered heterozygous missense mutations in SAM

202 A new study uncovers how two plants connect and demonstrates t

203 Our study uncovers IL-21 deficiency as a novel cause of earl

204 These studies uncover important connections between inflammati

205 Collectively, this study uncovers key features of the 3D organization of ac

206 Our study uncovers key roles for TNF and, to a lesser extent

207 Our study uncovers MaIL1 as an integral RNA component of the

208 Together, our study uncovered many previously uncharacterized represso

209 Taken together, our study uncovers mechanisms by which epithelial cells acqu

210 This study uncovers mechanisms by which ionizing radiation, e

211 Collectively, this study uncovers mechanisms underlying the therapeutic eff

212 Taken together, our study uncovers mechanisms underlying ZIKV neuropathogene

213 This study uncovers molecular networks with considerable conv

214 These studies uncover multiple regions within Set5 that regula

215 Together, this study uncovers multiple defects of DNMT3A caused by the

216 Overall, our study uncovers multiple scales of population dynamics th

217 Thus, our study uncovered N-Myc induction and nutrient levels as i

218 These studies uncover new paradigms for the preferential speci

219 These studies uncover new physiological roles for GDE3 in glio

220 Here, we discuss recent studies uncovering new molecular pathways and metabolic

221 In sum, this study uncovers new anatomical and functional modules of

222 Our study uncovers new features of RNA recognition and splic

223 In conclusion, our study uncovers new insights into SHOC2 function and reve

224 This study uncovers new metabolic checkpoints for T cell acti

225 spectrometry and protein-protein interaction studies uncover novel associations between UBASH3A and c

226 Our studies uncover novel functions of MSN subtypes in depre

227 Our studies uncover opportunities for simultaneously treatin

228 These studies uncover parameters that can be tuned to maximize

229 Our study uncovers patterns of distinct BRAF clonal evolutio

230 Our molecular and genetic studies uncover PI3K/AKT2 as a direct PDGFA target that

231 The study uncovered poor management of diabetes along the ca

232 These studies uncover post-transcriptional regulation underlyi

233 Our studies uncover previously unidentified targets of HSF-1

234 Our study uncovers previously obscured finer-scale genome or

235 This study uncovers previously unknown mechanisms of Hippo re

236 Ultrastructural studies uncovered progressive dilation of the sarcoplasm

237 Our study uncovers RagA/B GTPases as key regulators of lysos

238 Collectively, our study uncovers REST in regulating EMT and stemness prope

239 otine dependence.SIGNIFICANCE STATEMENT This study uncovers several neuropharmacological alterations

240 Recent studies uncovered significant roles for intestinal micro

241 Together, this study uncovering Skp2-mediated Twist stabilization and o

242 The present study uncovers specific microRNA expression signatures a

243 This study uncovered substantial influence of the organized m

244 In vivo combination studies uncovered surprising benefits of low doses of AB

245 This study uncovers synergistic activation of Arg1 by RA and

246 In vivo studies uncover that EhActn2 plays an important role in

247 Mechanistic studies uncover that the activated ROS1 results from hig

248 These studies uncover that tubule-derived Shh triggers the ear

249 FCS and temporally resolved genetic studies uncovered that Antennapedia itself is necessary

250 mics and gene set enrichment analysis (GSEA) studies uncovered that CITED2 deficiency broadly enhance

251 scriptomics and gene set enrichment analysis studies uncovered that KLF6 deficiency attenuates broad

252 Collectively, our studies uncovered that KLF6 govern inflammatory and hypo

253 Electrophysiology and EM studies uncovered that the number of multigranular compo

254 The results in this study uncover that enzymes involved in PolyP homeostasis

255 This study uncover that proline can appropriately reduce lign

256 Taken together, this study uncovered that CdpR is an important QS regulator,

257 This study uncovers that a lipid pathway promotes neuronal fu

258 Taken together, our study uncovers that the capacity of vacuolar Cl(-) loadi

259 Therefore, our study uncovers that under normal conditions HuR modulate

260 Our studies uncover the complement of planarian GPCRs and re

261 Our studies uncover the underlying kinetic basis for a class

262 Soon after, studies uncovered the role of PCSK9 in the regulation of

263 ep and wake to lay the foundation for future studies uncovering the mechanisms that underlie the init

264 Altogether, our study uncovered the existence of a novel Akt-HSF-1 signa

265 This study uncovered the genetic regulation of fibre-cell dev

266 This study uncovered the Skp2-mediated CSC-like phenotype wit

267 Our study uncovers the 1q21.3-directed S100A7/8/9-IRAK1 feed

268 This study uncovers the defensive function of JA signaling in

269 Our study uncovers the evolutionary strategies by which vacc

270 Our study uncovers the first genetic evidence explaining why

271 Our study uncovers the fundamental role of binocular experie

272 his comprehensive genomic and transcriptomic study uncovers the genetic basis of key evolutionary ada

273 This study uncovers the indispensable contributions of dopami

274 Our study uncovers the loss-of-function mutation in ZBTB7A a

275 This study uncovers the mechanism underlying Plk4 activation

276 This study uncovers the metabolic mechanisms by which IL-7 ta

277 In sum, our study uncovers the molecular basis of a major nuclear fu

278 This study uncovers the molecular function of the natural var

279 Our study uncovers the molecular heterogeneity of SLE and pr

280 Collectively, our study uncovers the mutual association between the qualit

281 This study uncovers the opportunity to use properties of hepa

282 Our study uncovers the pathogenic mechanism whereby absence

283 Overall, our study uncovers the pleiotropic role of otoferlin in the

284 Our study uncovers the postsynaptic function of the SNAP25-V

285 Therefore, this study uncovers the previously inaccessible kinetics and

286 This study uncovers the role for general splicing machinery i

287 This study uncovers the role of anisotropic spin-orbit coupli

288 Our study uncovers the role of chirality in defining the mes

289 This study uncovers the role of temperature in environmental

290 This study uncovers the role of weak noncovalent interactions

291 Our study uncovers the structural basis for LPS recognition,

292 Our study uncovers the widespread occurrence and strong immu

293 This study uncovers two competing processes triggered by viru

294 Our study uncovers two distinct mechanisms by which motivati

295 Our study uncovers unexpected differences between monocytes

296 In addition, the study uncovers unexpected exosomal transfer of this micr

297 The studies uncover unique properties of B6-(F) Mes, includi

298 This study uncovers unique gene signatures that define tissue

299 Our study uncovers unknown effects of RT delivered on a woun

300 Furthermore, our study uncovered well known and new PPXY-WW1-interacting