ライフサイエンスコーパス: subcellular

1 studied how the photophysical properties and subcellular accumulation of nonconventional coumarin-bas

2 dence indicates that external stress-induced subcellular adaptation is accomplished through dynamic c

3 epending on the stress and that its terminal subcellular address influences the decision between init

4 These new approaches allow for the subcellular analyses of unstained vitrified cells and th

5 Direct visualization of 3D subcellular and nano-scale structures in cells is helpfu

6 as a method capable of tracking the dynamic subcellular and protein interaction "social network" of

7 r/microcircuit level, in which the molecular/subcellular and systems levels meet.

8 However, a correlative approach that enables subcellular antibiotic visualisation in pathogen-infecte

9 r mapping the wider spatial relationships in subcellular architectures.

10 TT171 fragments can dramatically alter their subcellular behavior and pathogenicity.

11 Finally, mutant HTT subcellular behavior is strongly modified by different c

12 ing, immunoprecipitation, mass spectrometry, subcellular binding pattern analyses in primary neuronal

13 a unique instance of spatial patterning in a subcellular biological system.

14 ces is via microvesicle particles, which are subcellular bodies released directly from cellular membr

15 hed in cells undergoing the initial steps of subcellular branching as a direct response to FGF signal

16 n atrial myocytes predisposes these cells to subcellular Ca waves that occur during the action potent

17 is driven by the underlying stochasticity of subcellular Ca waves, which perturbs AP repolarization a

18 rates a new role for the circadian system in subcellular Ca(2+) signalling, in addition to its role i

19 aging in awake mice, we observed spontaneous subcellular calcium events as well as strong agonist-evo

20 cludes important aspects of the TME spanning subcellular-, cellular- and tissue-level scales.

21 generated by these receptors and a change of subcellular cGMP compartmentation.

22 The subcellular changes in dendritic mitochondria and histoc

23 ly relevant cell states involve cellular and subcellular changes that are only accessible by microsco

24 r changes (cell-cell interactions as well as subcellular changes) that accompany human cell fate tran

25 ese data highlight how protein import into a subcellular compartment can be regulated by ubiquitinati

26 fected by both the sex of the animal and the subcellular compartment in which the receptor is express

27 The primary cilium constitutes a subcellular compartment that orchestrates signal transdu

28 re mediated by protein complexes within this subcellular compartment.

29 Subcellular compartmentalisation is necessary for eukary

30 tion and protein activity, achieving precise subcellular compartmentalisation of RAB13 protein functi

31 se receptors to fine membrane structures and subcellular compartmentation of beta(3)-AR/cGMP signals

32 embrane contact sites (MCSs) are specialized subcellular compartments formed by closely apposed membr

33 termine that endogenous PFK-1.1 localizes to subcellular compartments in vivo.

34 segregate molecules and reactions in various subcellular compartments known as organelles.

35 ntial firing drives calcium responses within subcellular compartments of male rat spinal cord lamina

36 Thus, the activation of acetate in distinct subcellular compartments provides plants with the metabo

37 years as a driving force for the assembly of subcellular compartments termed membraneless organelles.

38 and cytoskeleton act in concert in distinct subcellular compartments to drive forward cell migration

39 very in plants are unable to target specific subcellular compartments with high precision, limiting o

40 is considered a protein present in these two subcellular compartments, and here we report that it not

41 of autophagy are distributed across neuronal subcellular compartments, how local machinery regulates

42 strubtion of ERK susbtrates across different subcellular compartments, it is important to understand

43 rent roles in allantoin distribution between subcellular compartments.

44 lies have been programmed to target specific subcellular compartments.

45 1 variant overexpression implicate different subcellular compartments.

46 of metabolomic and proteomic dynamics within subcellular compartments.

47 zymes often have different roles in distinct subcellular compartments.

48 rsistence of norBNI receptor inactivation in subcellular compartments.

49 nalysis of fractions confirmed separation of subcellular compartments.

50 ostic nanoparticles (NPs) to enter cells and subcellular compartments.

51 characterization of novel gene products and subcellular complexes.

52 nal model of a deformable cell that includes subcellular components responsible for mechanosensing.

53 Disease can induce changes to subcellular components, altering cell phenotype and lead

54 spatially concordant or discordant, such as subcellular concordant or discordant Ca2+alternans in ca

55 Many subcellular condensed bodies are hierarchically organize

56 ic cell and delivers cargo proteins to their subcellular destinations, such as sites of action or deg

57 pability to quickly scan intact samples with subcellular detail, the DeepDOF microscope can improve t

58 orescence microscopy can reveal cellular and subcellular details down to the molecular level with flu

59 ces of SNX14 mutations to be consequences of subcellular disruption to autophagy and lipid metabolism

60 these findings provide new insights into the subcellular distribution and roles of specific PATs and

61 channel activity, and pendrin abundance and subcellular distribution in wild-type and intercalated c

62 nse, we measured pendrin label intensity and subcellular distribution in wild-type mice, knockout mic

63 ealed stiffness-dependent differences in the subcellular distribution of actomyosin contractility, wi

64 oblasts and that HIPK4 deficiency alters the subcellular distribution of an F-actin capping protein i

65 In L924P there was also altered subcellular distribution of endogenous alpha1 subunit, a

66 In this study, we found that the subcellular distribution of Hsp82 is regulated by its co

67 The subcellular distribution of lipids in human hair was inv

68 We therefore comprehensively determined the subcellular distribution of mammalian PATs in dorsal roo

69 sed several orthogonal approaches to map the subcellular distribution of PI, including localizing exo

70 aimed to identify changes in expression and subcellular distribution of proteins involved in IMTG st

71 In agreement, the subcellular distribution of Rad23 is noticeably altered

72 valuable tool to experimentally modulate the subcellular distribution of seed storage proteins.

73 The subcellular distribution of the ClC-5:S244L variant was

74 We discovered a strictly segregated subcellular distribution of these proteins and a sequent

75 In general, the cortex structure and subcellular distribution vary significantly across cell

76 inase A anchoring proteins, which alters its subcellular distribution.

77 ct on pendrin total and apical abundance and subcellular distribution.

78 t (AIS) of excitatory pyramidal neurons; the subcellular domain where action potentials are initiated

79 ambiguity is critical as CaM is enriched in subcellular domains where Ca(V) channels reside, such as

80 On the basis of subcellular dosimetry, (125)I-KX1 was approximately twic

81 Thus, subcellular drug-delivery holds promise as a means to re

82 tion to visualize and analyse the growth and subcellular dynamics of individual wild-type and mutant

83 on and simulation of SBML representations of subcellular dynamics within multiscale models of epithel

84 We revealed the subcellular enrichment of glycogen in live cancer cells

85 Thus, translation of RAB13 in specific subcellular environments imparts the protein with distin

86 and that this modification can contribute to subcellular fascin localization and function.

87 The subcellular fate of splicing variants AtUPS5L (long) and

88 ction-limited optical performance to resolve subcellular features can be maintained while significant

89 restingly, SIMR-1 also localizes to distinct subcellular foci adjacent to P granules and Mutator foci

90 the potential of this approach by revealing subcellular force patterns throughout phagocytic engulfm

91 results provide general insight into how the subcellular forces are generated and maintained within i

92 Subcellular fractionation analysis using OptiPrep densit

93 Subcellular fractionation confirmed that human tau is hi

94 Here, we utilized subcellular fractionation coupled with tandem mass spect

95 Immunocytochemistry and subcellular fractionation gave consistent results demons

96 Microscopy and subcellular fractionation studies in macrophages demonst

97 Using subcellular fractionation, an improved sequence database

98 gh immunofluorescence staining, immunoblots, subcellular fractionation, and immunoprecipitation exper

99 ted gene silencing, confocal microscopy, and subcellular fractionation, we identified a nuclear varia

100 sed heart especially in organelle-containing subcellular fractions.

101 s in Na,K-ATPase subunit distributions among subcellular fractions; and greater inactivation of eIF2a

102 Herein, neutrophil subcellular granules were fractionated by Percoll densit

103 h remains unknown about the roles of Sac1 in subcellular homeostasis and organismal development.

104 i neurons in zebrafish embryos together with subcellular imaging, optogenetics, and photopharmacology

105 cting structural and functional cellular and subcellular information on complex mammalian bodies and

106 architectures, inability to form uniform and subcellular interfaces, or faradaic reactions at electro

107 val state and what happens at a cellular and subcellular level are largely unknown.

108 ty influences efficient CSC transport at the subcellular level remain unknown.

109 action rate of primary cardiomyocytes at the subcellular level to target frequency in vitro.

110 ocesses, particularly those occurring at the subcellular level, critically control the formation of c

111 to interrogate biological soft matter at the subcellular level, in this case, on a cellular model of

112 ion of TPP dynamics within live cells at the subcellular level.

113 x, which is driven by redox chemistry at the subcellular level.

114 mination of absolute protein abundances at a subcellular level.

115 in developmental biology but less so at the subcellular level.

116 e-of-the-art tissue-clearing methods provide subcellular-level optical access to intact tissues from

117 helial cells to conferring new properties at subcellular levels to regulate collective cell behavior.

118 etabolic disruption at both the cellular and subcellular levels.

119 s a p53-responsive lncRNA that regulates p53 subcellular levels.

120 impaired organellar interfacing, to propose 'subcellular lipidome imbalance' as a likely common patho

121 has provided insights on membrane reshaping, subcellular localisation of components, host-pathogen in

122 inferred losses), accompanied by changes in subcellular localisations and substrate specificities.

123 Population genomic and subcellular localization analyses strongly suggest a sin

124 p11 regulates the subcellular localization and cellular level of the potas

125 ncMTOCs are diverse in their composition, subcellular localization and function.

126 t FUS acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS,

127 anulin readthrough protein displayed similar subcellular localization as the wild-type progranulin pr

128 s in close proximity to Tim-3 and alters its subcellular localization by directing it to Rab 5-positi

129 ons, as well as SHELL heterodimerization and subcellular localization by yeast two-hybrid, bimolecula

130 Among these were several proteins that lack subcellular localization data or that are currently assi

131 nt in brain development, the extent to which subcellular localization differs as the brain matures ha

132 use of time-gating allowed the precise DEK1 subcellular localization during 3D morphogenesis.

133 Here, we report examination of the dynamic subcellular localization of all three RLRs within the in

134 ion in U. maydis, interacts and controls the subcellular localization of Biz1, a transcriptional fact

135 es have implicated changes in expression and subcellular localization of connexin-43 (Cx43), the majo

136 The subcellular localization of enzymes that catalyze allant

137 We systematically examine the dynamic subcellular localization of glycolytic protein phosphofr

138 We report differing subcellular localization of lncRNAs in human and mouse e

139 Our findings demonstrate that the subcellular localization of Mad1 is tightly coordinated

140 the formation of membraneless organelles and subcellular localization of numerous proteins.

141 Immunocytochemistry of the subcellular localization of PC7 and its Ala variants of

142 e present study describes the expression and subcellular localization of PDLIM1 for the first time, a

143 reserves the native structure, activity, and subcellular localization of PTP1B, affords changes in ac

144 ic mRNAs, we describe for the first time the subcellular localization of selected Par proteins in bla

145 We examined the subcellular localization of SlpA secretion and S-layer g

146 imate striatum, we compared the cellular and subcellular localization of striatal GluD1 immunoreactiv

147 tion is unknown, raising questions about the subcellular localization of the final stage of TPP biosy

148 reporter system to evaluate the kinetics and subcellular localization of the interaction of ASO and P

149 fically interacts with SART3, regulating the subcellular localization of the protein deubiquitinase U

150 titioning could be accompanied by changes in subcellular localization of the protein products.

151 We investigate the expression and subcellular localization of the SARS-CoV-2 receptor, ang

152 determine the endogenous gene expression and subcellular localization of the sole Na(V) channel in bo

153 osphorylation controls RING domain-dependent subcellular localization of TRAF2 to modulate the spatio

154 Here, we report a novel subcellular localization of zebrafish Crb1 in retinal co

155 by using local mitochondrial polarity and a subcellular localization redistribution property of the

156 Analysis of lncRNA 1810058I24Rik subcellular localization revealed that this transcript w

157 The effect of each alteration on subcellular localization was also determined.

158 between the activity of CAs (with different subcellular localization, abundance and gene expression)

159 nteraction with biomembranes, differences in subcellular localization, and relocalization after irrad

160 ssay, CyQuant, annexin V, JC-1, cytochrome C subcellular localization, caspase 3 activation, and immu

161 ges affect delivery efficiency and determine subcellular localization, effects that could permit the

162 rmation on PKARIalpha catalytic activity and subcellular localization, live-cell fluorescence imaging

163 As ICAP1 controls KRIT1 subcellular localization, presumably influencing KRIT1 f

164 found that protein turnover is influenced by subcellular localization, protein function, complex asso

165 d super-resolution microscopy, light-induced subcellular localization, reaction-diffusion modelling a

166 ocyte damage is not clear, including APOL1's subcellular localization, topology, and whether the dama

167 ough its transmembrane domain and alters its subcellular localization.

168 substrate specificity, ligase activity, and subcellular localization.

169 d on its posttranslational modifications and subcellular localization.

170 mensions: space, time, sex, environment, and subcellular localization.

171 gth scale associated with the concept of SFK subcellular localization.

172 nstrate a robust, yet tunable, mechanism for subcellular localization.

173 applications for further analysis, including subcellular localization.

174 lex formation but does partially control its subcellular localization.

175 ried partial loss of function despite proper subcellular localization.

176 cells as well as their turnover kinetics and subcellular localization.

177 translational modification that controls its subcellular localization.

178 everely disrupted function without affecting subcellular localization.

179 el subunit (Kv1.1), thereby regulating Kv1.1 subcellular localization.

180 disassembly of such substrates in different subcellular localizations and, hence, power a plethora o

181 However, how PLKs are targeted to distinct subcellular localizations during meiotic progression rem

182 cts leads to protein products with different subcellular localizations, we propose that after gene du

183 ration and phagocytic processing at distinct subcellular localizations: Trpml regulates hemocyte migr

184 ematic and comprehensive analysis of protein subcellular location as a critical part of proteomics ('

185 rom the Human Protein Atlas as the source of subcellular location information, and built classificati

186 lification method to noninvasively image the subcellular location of RNA targets in living cells.

187 Y RNAs regulate the subcellular location of Ro60, since Ro60 is reduced in t

188 ols for mapping the spatial distribution and subcellular location of target analytes.

189 t-inducible nuclear exporter, to control the subcellular location of the H2Bub1 E3 ligase, Bre1.

190 Here, we determine the steady-state subcellular location of thousands of proteins simultaneo

191 We show that Inp1 is present in the correct subcellular location to interact with both the plasma me

192 l peptidoglycan synthase activity at a given subcellular location.

193 enzymes regulate this process at a distinct subcellular location.

194 ns and in gene regulation, we analyzed their subcellular locations and DNA-affinities.

195 udied for many years, but annotating protein subcellular locations and understanding variation of the

196 The sorting of RNA molecules to subcellular locations facilitates the activity of spatia

197 timate the fractions of protein in different subcellular locations, and can help to quantify the chan

198 ycosylation between individuals, cell types, subcellular locations, and pathophysiological conditions

199 Cofactors can target PP1 to substrates or subcellular locations, but it remains unclear how they m

200 fined understanding of signaling at distinct subcellular locations.

201 lasm without being constrained to particular subcellular locations.

202 econd messenger produced at several discrete subcellular locations.

203 clear how this complex is regulated at other subcellular locations.

204 activity is temporally regulated at specific subcellular locations.

205 nting ectopic functionality at inappropriate subcellular loci and orienting tissue morphogenesis.

206 Subcellular lumen formation by single-cells involves com

207 rosomes are key players in the initiation of subcellular lumen formation in Drosophila melanogaster,

208 h leads to the extension and guidance of the subcellular lumen within the tracheal terminal cell (TC)

209 rval tracheal TC leading to cells with extra-subcellular lumina.

210 own on the what leads to the growth of these subcellular luminal branches or makes them progress thro

211 ed for optogenetics, targeted cell ablation, subcellular manipulation, and imaging.

212 n leak and uncoupling as a potentially novel subcellular mechanism for the maturational failure of ol

213 ess granules (SGs) are prominent examples of subcellular, membraneless compartments that are observed

214 ter combinations of signaling enzymes within subcellular microdomains.

215 Using intravital subcellular microscopy, we reveal that LTB4 elicits sust

216 However, the role of subcellular mitochondrial trafficking during cell protru

217 ould be effectively suppressed by inhibiting subcellular mitochondrial trafficking.

218 n during cell migration that is regulated by subcellular mitochondrial trafficking.

219 o the oscillatory regime, as observed in the subcellular model and experimentally.

220 Both the full subcellular model and the minimal model present the same

221 Using an in-silico subcellular model of rabbit ventricular myocyte, we show

222 invasion, but has not incorporated detailed subcellular modelling RESULTS: We present a framework th

223 cell reporter, pHluorin-CD63, allows dynamic subcellular monitoring of exosome secretion in migrating

224 identification of platelets, and 4) detailed subcellular morphology.

225 namically regulates signaling by controlling subcellular NAD(+) concentrations.

226 entalizing NAD(+), and methods for measuring subcellular NAD(+) levels.

227 en cells that can be controlled spatially on subcellular or tissue scale via photocleavage.

228 s enabled functional imaging of cellular and subcellular organelles at <=50 nm resolution.

229 Mitochondria are subcellular organelles best known for their central role

230 zing and tracking target biomolecules and/or subcellular organelles labeled with imaging probes.

231 o rapidly and reversibly recruit proteins to subcellular organelles, to induce organelle contacts, an

232 or visualizing cell membranes and eukaryotic subcellular organelles.

233 s of biological systems, including cells and subcellular organelles.

234 neless organelles play a crucial role in the subcellular organization of bacterial cells.

235 e powerful imaging methods for exploring the subcellular organization of biomolecules.

236 Subcellular organization of RNAs and proteins is critica

237 phenomenon whereby global cell shape affects subcellular organization to modulate signaling that enab

238 emerged as a new paradigm for understanding subcellular organization, prebiotic life, and the origin

239 TIL function by inducing a state of impaired subcellular organization.

240 lar and extracellular structures may have on subcellular oxygen availability.

241 3sigma in skin keratinocytes, shows aberrant subcellular partitioning and function in differentiating

242 A-approved KIs and classify their effects on subcellular pathways and processes.

243 us to investigate the effect of mutations in subcellular pathways on the migration of cells within th

244 e morphology, cytoskeletal organization, and subcellular pattern of force generation in corneal kerat

245 s a novel platform enabling the profiling of subcellular phenotypes associated with perturbation.

246 onfined spaces within a microfluidic device, subcellular photoactivation of Rac1, diffusion of cytopl

247 , I discuss NAD(+) metabolism, how different subcellular pools of NAD(+) are established and regulate

248 between PI availability and the turnover of subcellular PPIn pools.

249 ighly controlled photothermal stimulation at subcellular precision without the need for genetic modif

250 high-resolution studies of many systemic and subcellular processes in larvae.

251 model system to investigate the cellular and subcellular processes underlying complex cell-shape dete

252 ganelles facilitates the focused analysis of subcellular protein and metabolite pools.

253 n fluorescent protein (VHA(B) -eGFP) enabled subcellular protein localization in live cells.

254 tion of mRNAs provides an efficient means of subcellular protein localization.

255 for mapping protein-protein interactions and subcellular proteomes in live mammalian cells.

256 es first allowed the observation of peculiar subcellular protrusions along tanycyte processes and at

257 The integration of subcellular Raman spectro-microscopy with lipidomics and

258 unction of P2Y11 receptors depended on their subcellular redistribution and autocrine stimulation by

259 cpRAPID system enables chemical-controllable subcellular redistribution of proteins, as well as induc

260 vely at the biochemical level, analyzing the subcellular redox dynamics of NAD in living plant tissue

261 s of improved biosensors targeted to various subcellular regions via sequence specific motifs to meas

262 gulation of microtubule dynamics resolved to subcellular regions within individual neurites.

263 Dynamic subcellular regulation of protein kinase A (PKA) activit

264 ) and the mesenchymal marker vimentin (V) at subcellular resolution ("EMT-IFA").

265 sive study of complex glycogen metabolism at subcellular resolution and may help reveal new features

266 ria in live or fixed osteosarcoma cells with subcellular resolution at 1 nM, but also efficiently con

267 ircuits over large volumes at high speed and subcellular resolution is a difficult task.

268 hibit a large increase in fluorescence, with subcellular resolution, subsecond kinetics and nanomolar

269 ces, providing spatial force measurements at subcellular resolution.

270 tudinal imaging of the Drosophila abdomen at subcellular resolution.

271 iological activities in living subjects with subcellular resolutions.

272 utility of HuRI in identifying the specific subcellular roles of protein-protein interactions.

273 ological function of single lipid species on subcellular scales in quantitative live-cell experiments

274 This subcellular segregation coincides with DREPP-dependent M

275 phosphatases regulate a myriad of essential subcellular signaling events, yet they remain difficult

276 which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during host r

277 Puromycylation assays reveal subcellular sites, such as nuclei, where puromycylated p

278 which a uridine-adding enzyme is anchored to subcellular sites, where it directly marks RNAs with 3'

279 tant for function, yet mechanisms underlying subcellular size control are largely unexplored.

280 ical circuits that involves the differential subcellular sorting of family-related synaptic proteins.

281 y how this process is controlled in time and subcellular space and integrated with the cell's protein

282 acterizing viral components and processes in subcellular space.

283 ity for biological imaging through combining subcellular spatial resolution with high-performance Orb

284 sions, (ii) resolving anatomical features at subcellular spatial resolution, (iii) biomolecular profi

285 To monitor subcellular sphingomyelin distribution, we generated a l

286 so vary between atrial myocytes depending on subcellular structure and electrophysiology.

287 ving 3D sub-diffraction-limit information in subcellular structures and organelles that have rotation

288 To study the interactions between subcellular structures involved in transducing mechanica

289 lled 'tomography-guided 3D reconstruction of subcellular structures' (TYGRESS) that is a hybrid of cr

290 icroscopy is a powerful tool for visualizing subcellular structures, interactions and protein functio

291 te mitochondrial defects in distinct retinal subcellular structures, the vascular/neural network in D

292 The mechanisms underlying subcellular targeting of cAMP-generating adenylyl cyclas

293 ritical determinant of neuronal output, with subcellular targeting of synaptic inhibition able to exe

294 plication history, alternative splicing, and subcellular targeting patterns to identify cases of subl

295 We illustrate our methods from the subcellular to millimeter spatial scale on diverse sampl

296 gnitude, direction, and strain dynamics from subcellular to tissue length-scales.

297 ferential posttranslational modification and subcellular trafficking, potentially resulting in select

298 We have analyzed subcellular transcriptomes of FMRP-null mouse neuronal c

299 ults suggest that attempts to define precise subcellular translation sites using anti-puromycin immun

300 ical structure of the heart, but also on its subcellular (ultrastructural) architecture, which enable