ライフサイエンスコーパス: subcellular target

1 d in more precise reconstructions of complex subcellular targets.

2 stem are directed onto specific cellular and subcellular targets.

3 is tightly regulated in both activity and in subcellular targeting.

4 y, the type I activation loop is also key in subcellular targeting.

5 the biological consequence of this specific subcellular targeting.

6 domain located at its N terminus involved in subcellular targeting.

7 east was improved by manipulation of protein subcellular targeting.

8 , is up-regulated 2.5-fold without change in subcellular targeting.

9 and common DISC1 amino acid substitutions on subcellular targeting.

10 r cellular complement, expression level, and subcellular targeting.

11 ol of mRNA translation rates, stability, and subcellular targeting.

12 h a concomitant isoform switch and change of subcellular targeting.

13 tions, such as interactions with proteins or subcellular targeting.

14 or pRTL2 plasmids, and used to study protein subcellular targeting.

15 Subcellular targeting analysis by fluorescence microscop

16 The subcellular target and cellular uptake mechanism of the

17 modulated by a combination of stage-specific subcellular targeting and assembly dynamics.

18 e of the SUMO-interacting motif (SIM) in the subcellular targeting and cellular functions of EPAC1.

19 apoptotic effect of PAK-2p34 is regulated by subcellular targeting and degradation by the proteasome.

20 extent alternative splicing might influence subcellular targeting and function of ClC-3.

21 ac2 crystal structure, is important for Epac subcellular targeting and in vivo functions.

22 rget for protein kinases and be required for subcellular targeting and membrane clustering of the rec

23 f beta4, a subunit predicted to regulate the subcellular targeting and modulation of both P/Q- and N-

24 y seems to be controlled by IKK interaction, subcellular targeting and oxidative stress conditions.

25 dysfunction required an intact pore, correct subcellular targeting and Rab interactivity of TPC2.

26 These in vivo and in vitro subcellular targeting and recombinant expression experim

27 a1 variants and explored their roles in Duox subcellular targeting and reconstitution.

28 C15 or C20 isoprenoid moieties) may mediate subcellular targeting and regulation of activity; and se

29 protein function largely depends on specific subcellular targeting and specific interactions with cel

30 Subcellular targeting and the activity of facilitative g

31 protein targeting sequences, mutant signals, subcellular targets and source organisms.

32 Multiple mechanisms regulate the properties, subcellular targeting, and cell-surface expression of Kv

33 r, these results suggest that actin binding, subcellular targeting, and dimerization are associated i

34 ly crucial for endoplasmic reticulum export, subcellular targeting, and fibril formation by Pmel17 an

35 ncluding reductions in intrinsic conduction, subcellular targeting, and protein stability.

36 R/K-V/I-X-F) in a family of proteins mediate subcellular targeting, and the amino acids that form the

37 Our subcellular targeting approach can be transferred to oth

38 th identity of the linker and control of its subcellular targeting are highly modular.

39 ailed overview of the recent developments in subcellular targeting as a novel platform for next-gener

40 how this functional diversity affects their subcellular targeting behaviors, we measured the binding

41 in complexes that are likely involved in the subcellular targeting, cytoskeletal anchoring, and local

42 nce lifetime microscopy O(2) sensors without subcellular targeting ("cytosol") or with targeting to t

43 ic endosomes, but its pH sensitivity and its subcellular targeting differed from transferrin.

44 This domain is responsible for the subcellular targeting differences between gamma and delt

45 We have determined the subcellular targeting domain of delta(E) CaMK-II, an iso

46 ficially localized to the cell edge with the subcellular targeting domain of Rap1a, it increases cell

47 ers is a challenge because the dimensions of subcellular targets (e.g., the cell nucleus) are of the

48 Examination of coding sequences and subcellular targeting elements indicated that the comple

49 ional simulations indicate that the observed subcellular targeting enables control over the nonlinear

50 nction in heterologous cells is regulated by subcellular targeting, endocytosis, and intracellular tr

51 We utilized subcellular targeted fluorescence resonance energy trans

52 d (4) the neuromuscular synapse is a primary subcellular target for muscle ERK1/2 function in vivo.

53 R and further demonstrates the importance of subcellular targeting for optogenetic actuators and repo

54 The subcellular targets for the majority of these effectors

55 Here we show, using subcellular-targeted, genetically encoded hemoprotein pe

56 they are targeted to, and we monitored their subcellular targeting in living cells.

57 The selectivity of expression and subcellular targeting in the host is enabled by applying

58 ome and into pRTL2 plasmids to study protein subcellular targeting in the presence and absence of vir

59 ug is sequestered away from the nucleus, its subcellular target, in vesicles expressing each of the t

60 ophagy has been shown to selectively degrade subcellular targets, including proteins, organelles, and

61 ases share 73% identity, provide no apparent subcellular targeting information, and predict inclusion

62 amilies contain distinct regulatory domains, subcellular targeting information, and substrate specifi

63 These findings indicate that subcellular targeting is a critical determinant of eNOS

64 system for delivery into mammalian cells and subcellular targeting is demonstrated by marking organel

65 llipodia and membrane ruffles, and that Fgd1 subcellular targeting is dynamic.

66 Efficient delivery of therapeutic agents to subcellular targets is a major challenge in pharmacology

67 a large Stokes shift, and displays intrinsic subcellular targeting, its compatibility with super-reso

68 However, the subcellular targeting mechanism of these proteins is unk

69 environments; (ii) allow for integration of subcellular targeting moieties; (iii) reduce toxicity; (

70 other in a tRNA-binding area and the 5'-end subcellular targeting motif area.

71 studies therefore identify mitochondria as a subcellular target of reperfusion damage and a site of a

72 e purpose of this study was to determine the subcellular target of the group IIA PLA(2) and its role

73 Thus, subcellular targeting of a chemoattractant can direct ou

74 Subcellular targeting of a single gene product in centra

75 Thus, both structural features and subcellular targeting of Ags can have strong effects on

76 The subcellular targeting of alpha2 to the transverse tubule

77 However, notable differences exist in the subcellular targeting of alternatively configured comple

78 exon I-derived 5' UTR has a distinct role in subcellular targeting of Bdnf mRNA.

79 differences in both the synaptic density and subcellular targeting of BLA inputs.

80 We therefore hypothesized that subcellular targeting of CaMKII can direct its substrate

81 The mechanisms underlying subcellular targeting of cAMP-generating adenylyl cyclas

82 investigated the effect of estradiol on the subcellular targeting of endothelial nitric oxide syntha

83 Both the post-translational processing and subcellular targeting of eNOS appear to be modified by c

84 onal modifications essential for the correct subcellular targeting of eNOS have not been described pr

85 These data suggest that the subcellular targeting of eNOS to caveolae can restrict N

86 th acylations are required for the efficient subcellular targeting of eNOS to plasmalemmal caveolae.

87 Disruption of the DEP-dependent subcellular targeting of Epac abolished cAMP-Epac-mediat

88 ctivation of PKB by Epac requires the proper subcellular targeting of Epac.

89 he I3 domain alone are sufficient for proper subcellular targeting of exogenous hDlg.

90 rosmotic conditions results from inefficient subcellular targeting of F-actin.

91 revealed that the mutation prevented proper subcellular targeting of FGF12 to the axon initial segme

92 Regulated membrane trafficking and subcellular targeting of GABA(A) receptors is important

93 el constructs unravel a presenilin-dependent subcellular targeting of gamma-secretase complexes.

94 The subcellular targeting of hNMT was also examined by immun

95 density-93 (PSD-93), a protein involved the subcellular targeting of ion channels and glutamate rece

96 Subcellular targeting of kinases controls their activati

97 Subcellular targeting of LpdA required a C-terminal moti

98 We trace this variance to the divergence in subcellular targeting of Mid1 and show that duplication

99 te that AMPK couples local energy demands to subcellular targeting of mitochondria during cell migrat

100 eby TGB protein interactions function in the subcellular targeting of movement protein complexes and

101 Since then, it has become clear that subcellular targeting of mRNAs is prevalent, and there i

102 The subcellular targeting of neurotransmitter receptors is v

103 We investigated the pathways underlying the subcellular targeting of NgCAM, a cell adhesion molecule

104 enous promoters were utilized to observe the subcellular targeting of Ntg1p and Ntg2p in S. cerevisia

105 Our results show that normal subcellular targeting of p27 is not subverted in E5/E8 c

106 Thus, subcellular targeting of parvalbumin reveals a distinct

107 We demonstrate that subcellular targeting of Pim1 bolsters the distinct card

108 p, determines both enzymatic specificity and subcellular targeting of PIP kinases.

109 We now demonstrate that the subcellular targeting of PKA through association with A-

110 at may allow for selective regulation and/or subcellular targeting of PP1 isoforms.

111 Subcellular targeting of protein kinases and phosphatase

112 These findings provide a mechanism for the subcellular targeting of RGS9-2 in neurons.

113 Interaction with R7BP is important for the subcellular targeting of RGS9-2, which in native neurons

114 the molecular determinants that specify the subcellular targeting of RGS9-2.Gbeta5.R7BP complex are

115 Subcellular targeting of signaling enzymes influences wh

116 at an important role for Hub1 is the correct subcellular targeting of Snu66, although our data sugges

117 ritical determinant of neuronal output, with subcellular targeting of synaptic inhibition able to exe

118 Subcellular targeting of the cAMP-dependent protein kina

119 Subcellular targeting of the components of the cAMP-depe

120 tion is a key determinant for the reversible subcellular targeting of the enzyme to plasmalemmal cave

121 Specific subcellular targeting of the sensor demonstrated rapid i

122 , we conducted a comparative analysis of the subcellular targeting of the two Pd-resident and two unr

123 basis for the transmembrane domain-mediated subcellular targeting of UBC6 was evaluated by lengtheni

124 We subsequently tested the subcellular targeting of yellow fluorescent protein fusi

125 To determine the precise subcellular targets of MOR agonists, immunoreactivity ag

126 in vivo HSP-70 expression, and that specific subcellular targets of PDT (which can differ for various

127 To identify the cellular and subcellular targets of trkB ligands in the adult rat hip

128 t-translational process, which may serve for subcellular targeting or membrane anchoring.

129 gged a series of known proteins with diverse subcellular targeting patterns as well as several protei

130 plication history, alternative splicing, and subcellular targeting patterns to identify cases of subl

131 the stable co-existence of plasmids in which subcellular targeting plays a major role.

132 Here, we identify the subcellular targeting potentials for nine CDPK isoforms

133 ctivation mechanism that may account for its subcellular targeting properties.

134 of C2 domains can account for most of their subcellular targeting properties.

135 and protein degradation can be avoided with subcellular targeting, protease mutants and co-expressin

136 In turn, subcellular targeting, protein-protein interactions, or

137 Subcellular target recognition in the CNS is the culmina

138 l function of NRP1 in both axon guidance and subcellular target recognition in the construction of GA

139 ed in BCs, controls both axonal guidance and subcellular target recognition.

140 the relationship between enzyme activity and subcellular targeting remains obscure.

141 t identified an N-terminal signal peptide or subcellular targeting sequence.

142 minal hypervariable domain (HVD) serves as a subcellular targeting signal.

143 ot affect phosphatase activity but encodes a subcellular targeting signal.

144 ether, these data show that PKCepsilon forms subcellular-targeted signaling modules with ERKs, leadin

145 uncated Lrmp-EGFP fusion proteins identified subcellular targeting signals in the C terminus of Lrmp;

146 full anti-protease activity and appropriate subcellular targeting signals, including the one embedde

147 functionally required Kunitz domain 1 and/or subcellular targeting signals.

148 ence quantum efficiency, larger diversity of subcellular targeting strategies, and improved selectivi

149 Using two-photon uncaging, we show that this subcellular targeting strongly influences synaptic effic

150 involved in targeting an mRNA to a specific subcellular target such as the germinal granules and sug

151 ontain motifs that serve as "signatures" for subcellular targeting, such as a nuclear localization si

152 PKC is known to participate in the enzyme's subcellular targeting, suggesting an additional mode of

153 Finally, subcellular targeting the CopC protein to plant vacuoles

154 Subcellular targeting the sensor to nerve terminals reve

155 ms from RI measurements of the corresponding subcellular targets, thereby achieving multiplexed micro

156 complex were shown to determine its precise subcellular targeting to either the outer segment of pho

157 strict requirement of Arf6 for RhoB-specific subcellular targeting to endosomes and biological functi

158 ferentially regulated by caveolin-1 mediated subcellular targeting to lipid raft/caveolae and in endo

159 structure-guided sensor design or on precise subcellular targeting to presynaptic boutons-allow singl

160 ordination, and the latter leads to specific subcellular targeting to the plasma membrane.

161 ta1-C2 governs its specific Ca(2+)-dependent subcellular targeting to the plasma membrane.

162 al lipid addition, membrane association, and subcellular targeting to the plasma membrane.

163 Subcellular targeting to the vicinity of preferred subst

164 its endocytosis is required to deliver NO to subcellular targets to cause hyperpermeability.

165 inguish between these mechanisms by applying subcellular targeting using a soft X-ray microbeam in co

166 A system named P2SL that infer protein subcellular targeting was developed through this computa

167 Ralpha both were presynaptic, although their subcellular targeting was distinct.

168 g electron-dense contrast agents to specific subcellular targets within intact cells.