ライフサイエンスコーパス: submicromolar

1 (100-17,000 Da), and concentration (neat to submicromolar).

2 helical peptide (THP) when the substrate was submicromolar.

3 ormations at a physiological Ca(2+) level of submicromolar.

4 mean-graph midpoint (MGM) GI50 values in the submicromolar (0.033-0.630 muM) range.

5 n A inhibited the viral entry process with a submicromolar 50% inhibitory concentration (IC50) (IC50

6 array of in vitro assays, we have identified submicromolar (600 nM) N1L antagonists belonging to the

7 We show herein that RS67333 is also a submicromolar acetylcholinesterase (AChE) inhibitor and

8 were the most potent derivatives exhibiting submicromolar activities; among them monoesters are part

9 Compounds had submicromolar activity against Mycobacterium tuberculosi

10 most potent compounds, 7g and 13, exhibited submicromolar activity against the replicating bacteria

11 A number of compounds demonstrated submicromolar activity in a cell line model of prion dis

12 n-JNK inhibitors were identified that showed submicromolar activity in a cellular assay.

13 very of potent and selective inhibitors with submicromolar activity in cells and clear mechanism of a

14 roach afforded a series of compounds showing submicromolar activity in HCV replicon assays.

15 Of 81 new chemotypes discovered, 30 showed submicromolar activity, including a 180-pM subtype-selec

16 inhibit Shp2 over Shp1 and PTP1B with low to submicromolar activity.

17 We demonstrated submicromolar affinities for 2-OG and ferrous iron and H

18 in produces highly selective MRI probes with submicromolar affinities for small molecules.

19 approach led to macrocyclized peptides with submicromolar affinities for TNKS and high proteolytic s

20 aled two nipecotic acid derived binders with submicromolar affinities.

21 proinflammatory cysteinyl leukotrienes with submicromolar affinities.

22 f IMPDH from the fungus Ashbya gossypii with submicromolar affinities.

23 the full-length Gag, binds the membrane with submicromolar affinities.

24 ns the myo-inositol ligand, which binds with submicromolar affinity (0.76 +/- 0.08 muM).

25 regions on the target guanylate cyclase with submicromolar affinity (apparent KD-values of 663 +/- 12

26 2a-CRIg dimer bound C3b-coated surfaces with submicromolar affinity (KD).

27 e ZA loop of Brd4, leading to compounds with submicromolar affinity and cellular target engagement.

28 remained bound to the side of F-actin with a submicromolar affinity and did not nucleate actin polyme

29 s PHD, binds Lys4-trimethylated histone 3 in submicromolar affinity and has been reported to have the

30 less complex than ritonavir have comparable submicromolar affinity and inhibitory potency for CYP3A4

31 ed linked molecules that bind to RPA70N with submicromolar affinity and minimal disruption of RPA's i

32 that the CAP WH2 domain binds INF2-DID with submicromolar affinity but has weak affinity for actin m

33 5) inhibitor sildenafil was found to possess submicromolar affinity for AA2AR.

34 The PPAR-alpha agonist fenofibrate exhibited submicromolar affinity for both receptors (pKi CB1, 6.3

35 col was developed, which led to ligands with submicromolar affinity for FKBP51 and FKBP52.

36 in MlcB binds the sole IQ motif of MyoB with submicromolar affinity in the absence and presence of Ca

37 n's disease, binds copper(II) ion (1:1) with submicromolar affinity in vitro.

38 Selected bicyclic peptides display submicromolar affinity to G4 structures and high selecti

39 I J-protein family, bound DnaK2 or HtpG with submicromolar affinity, and HtpG bound DnaK2 with microm

40 e compound, termed VU590, inhibits ROMK with submicromolar affinity, but has no effect on Kir2.1 or K

41 e cytoplasmic domain of ATP1A1 and FGF2 with submicromolar affinity.

42 roline-rich (PxxP) motif of Aplip1/JIP1 with submicromolar affinity.

43 e EF-Tu switch I region bound to AbDsbA with submicromolar affinity.

44 se soluble construct binds the receptor with submicromolar affinity.

45 point for the development of inhibitors with submicromolar affinity.

46 ly diverse molecules that bind to KEAP1 with submicromolar affinity.

47 ) and heparin is mainly enthalpy driven with submicromolar affinity.

48 en activators, plasmin, and plasminogen with submicromolar affinity.

49 on constants for all 12-mer sequences having submicromolar affinity.

50 -methylated at lysine 9 (H3K9me3/H3K9me2) in submicromolar affinity.

51 CSP binds c-di-GMP with submicromolar affinity.

52 l fragment associates with microtubules with submicromolar affinity.

53 olution, subsecond kinetics and nanomolar-to-submicromolar affinity.

54 nd the drug apixaban; two bound with low and submicromolar affinity.

55 ychotic, although it displays only moderate (submicromolar) affinity for the dopamine D(2) receptor.

56 VU590 was the first publicly disclosed, submicromolar-affinity (IC50 = 0.2 muM), small-molecule

57 e discovery and characterization of VU041, a submicromolar-affinity inhibitor of Anopheles (An.) gamb

58 anced, multifunctional profile consisting of submicromolar ALR2 inhibitory efficacy (IC50=0.99+/-0.02

59 -V27A and A/M2-L26F mutant ion channels with submicromolar and low micromolar IC50, respectively.

60 ory activity toward BChE with IC50 values in submicromolar and micromolar range and exhibited selecti

61 Instead, several gold analogues show submicromolar and selective antimicrobial activity again

62 high CBR affinity with Ki values within the submicromolar and subnanomolar ranges with interesting m

63 NO coordinates tightly to CYP125 and CYP142 (submicromolar) and with a lower affinity (micromolar) to

64 features, including low nanomolar InhA IC50, submicromolar antimycobacterial potency, and improved ph

65 trypanosomal protease (K(i) = 0.6 pM) and a submicromolar antiparasitic activity (EC(50) = 0.67 muM)

66 ed a group of fluorine-substituted SBAs with submicromolar antiviral activity against HBV in human he

67 Reston, and Mengla viruses and is the first submicromolar antiviral agent reported for some of these

68 The six-residue cPT 9 (AAR029b) exhibited submicromolar antiviral potencies in inhibiting cell inf

69 usly and rapidly phase-separate from dilute (submicromolar) aqueous solutions into characteristic 'FG

70 Cyclization to II and III produced submicromolar AR antagonism and protein degradation sele

71 ive site and can be optimized to a selective submicromolar binder.

72 Ti surface from dilute aqueous solution with submicromolar binding affinities as determined by ELISA

73 long as the individual ligands had at least submicromolar binding affinities, they could be linked w

74 This is the first time that submicromolar binding affinity has been achieved for thi

75 the name of O-methylcorypalline), displayed submicromolar binding affinity toward the alpha4beta2 nA

76 e and surface plasmon resonance studies show submicromolar binding of copper/iron to NEILs but not OG

77 rthodox i,i+6 stapled peptide with improved, submicromolar binding to Ctf4.

78 from the rod photoreceptor is stimulated by submicromolar Ca(2+) and exhibits an unusually shallow d

79 esicles by hindering premature exocytosis at submicromolar Ca(2+) concentrations, whereas the N-termi

80 Submicromolar [Ca(2+) ] activates the channel via consti

81 out changing their sensitivity to activating submicromolar [Ca(2+) ](i) .

82 sulfamoylphenyl)-purine derivative exhibited submicromolar CDK2-inhibitory activity by virtue of engi

83 M2 and MDMX with nanomolar affinities, shows submicromolar cellular activities in cancer cell lines i

84 imH in a fluorescence polarization assay and submicromolar cellular activity in a hemagglutination (H

85 methyl reader and writer proteins, and with submicromolar cellular activity.

86 dine derivatizations provided compounds with submicromolar cellular FAK inhibition potential.

87 se, the most active representatives combined submicromolar cellular potency and nanomolar target affi

88 r cholesterol 27-hydroxylation either in the submicromolar (clevidipine, delavirdine, etravirine, fel

89 nable to image nuclear DNA in fixed cells at submicromolar concentration ([TP-2Bzim] = 100 nM) and to

90 ompounds inhibited tubulin polymerization at submicromolar concentration and inhibited cell growth at

91 d interrupts the lytic cycle of T. gondii at submicromolar concentration by targeting ASP3.

92 termination of trihalomethanes (THMs) at the submicromolar concentration level in water.

93 he NW sensors were found to be sensitive for submicromolar concentration of DA.

94 well-folded protein substrates using only a submicromolar concentration of enzyme.

95 ensitivity toward RSNO concentrations in the submicromolar concentration range.

96 inhibition of HDAC6 with IC50 values in the submicromolar concentration range.

97 adiolabeling studies showed that macropa, at submicromolar concentration, complexed all (225) Ac (26

98 generation and to stimulate fibrinolysis at submicromolar concentration.

99 says showed that binding of AI-2 occurs at a submicromolar concentration.

100 In slice cultures, submicromolar concentrations (0.001 microm) of C11 produ

101 phenol (4-MmC)] inhibits channel activity at submicromolar concentrations (IC(50) = 0.34 +/- 0.08 muM

102 layed potent antiproliferative properties at submicromolar concentrations (IC50 values; 100-500 nM),

103 At submicromolar concentrations 24(S)-HC potentiates NMDAR-

104 ion-dependent self-association that began at submicromolar concentrations and proceeded to dimer and

105 and pronounced photoinduced cytotoxicity at submicromolar concentrations in vitro, with an IC(50)(da

106 s (HCV) NS5A protein is virocidal for HCV at submicromolar concentrations in vitro.

107 We determined that CDDO analogues at submicromolar concentrations induce apoptosis of culture

108 recombinant neurexin to cultured neurons at submicromolar concentrations induced the same suppressio

109 ls that the 5-HT(5A) current is activated by submicromolar concentrations of 5-HT, is inwardly rectif

110 1252-resistant strains remained sensitive to submicromolar concentrations of AFN-1252, which blocked

111 Moreover, submicromolar concentrations of AZ-TAK1, a novel ATP-com

112 c integrity at either dose, however, whereas submicromolar concentrations of C11 did not interfere wi

113 Moreover, we demonstrate that addition of submicromolar concentrations of C1ql proteins to culture

114 Physiologic submicromolar concentrations of DIM protected cultured c

115 2, revealed significantly improved growth at submicromolar concentrations of exogenous heme.

116 Recently, we have demonstrated that submicromolar concentrations of Fe(II) significantly acc

117 th 24p3R or distal tubule cells internalized submicromolar concentrations of fluorescence-coupled pro

118 ear polarization allows for the detection of submicromolar concentrations of fluorinated small molecu

119 ose parallel with stomatal closure evoked by submicromolar concentrations of H2S.

120 human plasma and milk were found to contain submicromolar concentrations of protein N-linked Hcy, wh

121 When inhibited by siRNA or some by submicromolar concentrations of small-molecule inhibitor

122 trate superior antiproliferative activity at submicromolar concentrations of the prodrugs against a p

123 ating lack of NR2B subunits, and no block by submicromolar concentrations of zinc, consistent with NR

124 ontaining the KA1 subunit being sensitive to submicromolar concentrations of zinc.

125 which was alleviated by supplementation with submicromolar concentrations of Zn.

126 sts were cocultured with gammadelta cells in submicromolar concentrations of ZOL, we show that Vgamma

127 ress rimantadine resistance polymorphisms at submicromolar concentrations, and show activity against

128 bits growth of cancer cell lines in vitro at submicromolar concentrations, and significantly suppress

129 At submicromolar concentrations, E-12-NO2 derivatives were

130 n of all enveloped viruses tested at low and submicromolar concentrations, well below the range in wh

131 , as well as malaria parasites in culture at submicromolar concentrations.

132 2-induced monomethylation of p53 Lys(370) at submicromolar concentrations.

133 ii is susceptible to hBD-2 and -3 killing at submicromolar concentrations.

134 that shows in vitro cytotoxic activities at submicromolar concentrations.

135 clinically relevant mycobacterial species at submicromolar concentrations.

136 ch appears to stabilize this G-quadruplex at submicromolar concentrations.

137 1s, CDK16 and PIM3 at clinically achievable, submicromolar concentrations.

138 r l-allo-Ile inhibited carboxypeptidase A at submicromolar concentrations.

139 e entry of cell culture grown HCV (HCVcc) at submicromolar concentrations.

140 es not undergo dissociation upon dilution to submicromolar concentrations.

141 ophilin is dimeric in the cytoplasm, even at submicromolar concentrations.

142 in some AML cell lines, induced apoptosis at submicromolar concentrations.

143 e shown to potently inhibit HCV infection at submicromolar concentrations.

144 cancer cells with K-Ras mutations at low or submicromolar concentrations.

145 he viability of several lung cancer lines at submicromolar concentrations.

146 s, templated ligation occurs rapidly even at submicromolar concentrations.

147 ation of compounds 5 and 6 as hits active at submicromolar concentrations.

148 oiety and the detection of its hydrolysis at submicromolar concentrations.

149 tivity against several pathogenic strains at submicromolar concentrations.

150 ulin and inhibited tubulin polymerization at submicromolar concentrations.

151 fungal activity against filamentous fungi at submicromolar concentrations.

152 TR human bronchial epithelial (hBE) cells at submicromolar concentrations.

153 d proteome profiling identified CIAPIN1 as a submicromolar covalent target of VLX1570, and further an

154 mino, and methylsulfanyl derivatives exerted submicromolar cytotoxic effects in vitro against a panel

155 rated in buffer and in serum with associated submicromolar detection limits as low as 190 nM (buffer)

156 ncentration method to boost sensitivity with submicromolar detection limits for iodide (S/N approxima

157 lutions, we observed broad linear ranges and submicromolar detection limits.

158 of ISEs, yielding functional electrodes with submicromolar detection limits.

159 d at physiologically relevant micromolar and submicromolar DIM concentrations when cells were exposed

160 , and by the quantitative measurement of the submicromolar dissociation constant Kd (0.2 muM) of the

161 sugar were essential for achieving a low-to-submicromolar dissociation constant that was only slight

162 ll outgrowth in the lung by more than 90% at submicromolar doses.

163 ld-type and splice variant isoforms of AR at submicromolar doses.

164 e than half of the compounds tested showed a submicromolar EC(50) against these parasites.

165 ative activity in K562 and MV4-11 cells with submicromolar EC(50) values.

166 Several compounds from this study exhibited submicromolar EC50 values against S31N-containing A/WSN/

167 t yielded a number of potent antivirals with submicromolar efficacy against several human clinical is

168 vokes endocannabinoid release in response to submicromolar elevation of dendritic calcium that transi

169 omatic substitution did yield compounds with submicromolar enzymatic inhibition.

170 in the identification of a lead series with submicromolar enzyme inhibition, high ligand efficiency,

171 ided the optimization of the series yielding submicromolar enzyme inhibitors with promising cellular

172 II) on ligand-controlled dissolution even at submicromolar Fe(II) concentrations with up to a 13-fold

173 complement factor D inhibitor and exhibited submicromolar FXIa activity and an encouraging absorptio

174 Surprisingly, submicromolar H(2) O(2) poisoned the Isc machinery, ther

175 enhanced activity profiles, including 6 with submicromolar half maximal inhibitory concentrations.

176 SW48 colon cancer cells in particular with a submicromolar half maximum inhibition value mainly by in

177 nt that low concentration (few micromolar to submicromolar), highly turbid subglacial meltwater could

178 found in Dodonaea viscosa that constitutes a submicromolar, highly selective, and cell-active modulat

179 Structural modification of the submicromolar hit compound 3 led to the potent 3-methoxy

180 capillary morphogenesis gene 2 (CMG2) with a submicromolar IC(50) and also has antiangiogenic activit

181 roved anti-HAdV activities with nanomolar to submicromolar IC(50) values and high selectivity indexes

182 urther optimized, leading to inhibitors with submicromolar IC(50) values and improved lipophilic liga

183 o the identification of MtGS inhibitors with submicromolar IC(50) values and promising antituberculos

184 them, 13 compounds were identified as having submicromolar IC(50) values.

185 mpound 90, which inhibited the enzyme with a submicromolar IC50 (0.162 muM), capable of inhibiting th

186 We find that PGG inhibits CMG2 with a submicromolar IC50 and it also inhibits the migration of

187 ylphosphanes, was the most efficacious, with submicromolar IC50 concentrations.

188 a bone marrow-sparing compound, exhibited a submicromolar IC50 in 10 of 10 multiple myeloma cell lin

189 reaching of P-gp inhibitory activity at the submicromolar IC50 level.

190 iguration on cytotoxicity was confirmed with submicromolar IC50 values against HCT116 cells.

191 prostate cancer cells with low micromolar to submicromolar IC50 values as well as markedly enhanced a

192 nd kills G. lamblia trophozoites in vitro at submicromolar IC50 values.

193 M2 V27A mutant ion channel, one of them with submicromolar IC50.

194 techol) substituted thienopyrimidinones with submicromolar in vitro activity against both wild type H

195 h isomeric series) exerted low micromolar or submicromolar in vitro cytostatic activities against a b

196 w structural classes of GPR119 agonists with submicromolar in vitro potencies.

197 rations are able to stimulate physiological (submicromolar) increases in cGMP concentration in an act

198 ow 10 muM, with the best compound exhibiting submicromolar inhibition (IC50 = 0.8 muM).

199 ed by this methodology, with several showing submicromolar inhibition and exquisite selectivity again

200 h structural class, CM026 and CM037, exhibit submicromolar inhibition constants but have different me

201 four hCA isozymes (I, II, IX, and XII) with submicromolar inhibition constants, including perfluoroo

202 e most potent compound, 25 (FM26), displayed submicromolar inhibition in a coactivator recruitment as

203 )piperazine-1-carbothioamides, which exhibit submicromolar inhibition of bacterial Sfp-PPTase with no

204 lestaurtinib was highest ranked, exhibiting submicromolar inhibition of FGF14:Nav1.6 assembly.

205 bit low nM inhibition of both LDHA and LDHB, submicromolar inhibition of lactate production, and inhi

206 tural characterization of a highly selective submicromolar inhibitor of ALDH3A1, 1-[(4-fluorophenyl)s

207 ound 16 was identified as a highly selective submicromolar inhibitor of BuChE (huBuChE IC50 = 0.443 m

208 1,4]thiazine-6-carboxamide, 11 (ML276), is a submicromolar inhibitor of PfG6PD (IC(50) = 889 nM).

209 inhibit Tdp1 and identified compound 50 as a submicromolar inhibitor of Tdp1 (IC(5)(0) = 0.87 muM).

210 This compound was also found to be a submicromolar inhibitor of the class C ADC-7 and PDC-3 b

211 Initial fragment hit optimization led to a submicromolar inhibitor, which was cocrystallized with P

212 hibitors of this class of enzymes, achieving submicromolar inhibitors for ERAP2 (IC50 = 237 nM) and I

213 th a (3R)-hydroxyl configuration, are low to submicromolar inhibitors of beta-N-acetylhexosaminidases

214 series of compounds is the first example of submicromolar inhibitors of bromodomains outside the BET

215 Approximately 60% of the submicromolar inhibitors of PfKASIII inhibited in vitro

216 s revealed that four hasubanan alkaloids are submicromolar inhibitors of the N87 cell line.

217 the PPI between stonin2 and Eps15, producing submicromolar inhibitors.

218 hate pathway, in particular, was poisoned by submicromolar intracellular H(2)O(2).

219 vealed a specific Mn(2+) binding site with a submicromolar K(D).

220 (Cdc4) and makes a major contribution to the submicromolar K(m) of Cdc34 for SCF(Cdc4).

221 rous drug-protein interactions determine the submicromolar Kd of posaconazole for CYP46A1.

222 The aptamer binds to each dye with submicromolar KD values, and the resulting fluoromodules

223 Herein we describe the discovery of submicromolar ketohexokinase inhibitors with promising d

224 ing studies, granting a lead compound with a submicromolar Ki.

225 A round of optimization resulted in 11 new submicromolar KOR binders (best Ki = 90 nM).

226 detection for sulfide and cyanide are in the submicromolar level, with a linear dynamic range up to 1

227 lotriazadisulfonamide (CADA) inhibits HIV at submicromolar levels by specifically down-modulating cel

228 tric detection of S-nitrosothiols (RSNOs) at submicromolar levels in blood samples is of potential im

229 several micromolar, followed by recovery to submicromolar levels.

230 ions were scaled up and, after purification, submicromolar ligands based on two scaffolds with no pre

231 ation of 70 PDZ domains showed that ~40% had submicromolar membrane affinity.

232 he effort led to more than 10 compounds with submicromolar MICs and desirable physicochemical propert

233 Several compounds had submicromolar minimum inhibitory concentrations (MIC) ag

234 ese new agents are robust enough to maintain submicromolar PDT in pigmented metastatic melanoma cells

235 anules in the early embryo, with an apparent submicromolar phase boundary comparable to that measured

236 the compound 8a was selected as a selective submicromolar phosphodiesterase-4 (PDE4) inhibitor assoc

237 Molecule 1 had submicromolar photocytotoxicities to cells that were eng

238 wever, this Kd is still much higher than the submicromolar physiological I(-) concentration.

239 n the first AZT-derived 1,2,3-triazoles with submicromolar potencies against HIV-1.

240 ere later combined to produce analogues with submicromolar potencies, including 6-trifluoromethyl-3H-

241 discovery of multiple PRMT3 inhibitors with submicromolar potencies.

242 13755 (an arylstibonic derivative) displayed submicromolar potency (average IC(50) of 0.59 and 0.93 m

243 rivative 2a showed full agonist activity and submicromolar potency (EC(50) = 0.43 muM).

244 ML375 is a highly selective M5 NAM with submicromolar potency (human M5 IC50 = 300 nM, rat M5 IC

245 f P2X4 currents by extracellular BX430, with submicromolar potency (IC50 = 0.54 microM).

246 oacid hybrids, the majority of which exhibit submicromolar potency against 3'-end processing and stra

247 be a selective HCV NS5A inhibitor exhibiting submicromolar potency against both G-1a and G-1b replico

248 azol-2-yl)amino)benzoic acid (27), showing a submicromolar potency against purified CK2alpha (IC(50)

249 es, high activity in cell-free assays, and a submicromolar potency against T315I Bcr-Abl expressing c

250 a series of highly selective mGlu3 NAMs with submicromolar potency and good CNS penetration.

251 acarbocyanine iodide (compound 11), retained submicromolar potency and had calculated physical proper

252 otency; we show that diminazene indeed has a submicromolar potency at ASIC1a (IC50 0.3 muM).

253 Compounds 9b and 9c showed submicromolar potency at both human and rat mGluR4.

254 O-B, high hMAO-B over hMAO-A selectivity and submicromolar potency at hAChE.

255 hibit both SPP and gamma-secretase, but with submicromolar potency for SPP.

256 ited melanoma cell growth via apoptosis with submicromolar potency while sparing healthy cells.

257 y, is <100 nM potent against HDACs 2 and 10, submicromolar potent against HDACs 1, 8, and 11, and >50

258 finding a clear concentration dependence at submicromolar protein.

259 by iterative structure-based design to give submicromolar pyrazolopyridines with good ligand efficie

260 s were bactericidal for the export mutant in submicromolar quantities.

261 l phosphonium salt derivatives active in the submicromolar range (EC(50) from 0.04 to 0.28 muM, SI >

262 ith direct enzyme inhibiting activity in the submicromolar range (IC(50): 0.13-0.37 muM) were designe

263 ibits good antiproliferative activity in the submicromolar range against a human colon cancer cell li

264 omethyl substituents, with TPI values in the submicromolar range and cytotoxicities in the subnanomol

265 ost promising inhibitor, with an IC50 in the submicromolar range and high selectivity, relative to al

266 nsubstituted subtype 11 inhibited RNase H in submicromolar range and RT polymerase in low micromolar

267 cence sensing technique for glutamine in the submicromolar range based on the glutamine binding prote

268 These inhibitors display K(I) values in the submicromolar range for both sphingosine kinases and, in

269 -2 at median effective concentrations in the submicromolar range in ex vivo lymphoid and cervicovagin

270 inum complexes exhibiting IC50 values in the submicromolar range in the A2780 cell line.

271 d in vitro potency with IC(50) values in the submicromolar range was attained with electron-withdrawi

272 st potent compound (8g) inhibited hTP in the submicromolar range with a noncompetitive inhibition mod

273 possess anti-inflammatory activities in the submicromolar range with low cytotoxicity, and that the

274 nc complexes typically reached values in the submicromolar range with low toxicity in the dark (TC50

275 n the physiologically relevant micromolar to submicromolar range with the TGACGTCA canonical motif af

276 nds are highly potent on cancer cells in the submicromolar range without any toxicity on healthy cell

277 ists) but very potent TLR4/MD-2 antagonists (submicromolar range).

278 RNase H and polymerase with IC50s in low to submicromolar range.

279 were characterized by the IC(50) values in a submicromolar range.

280 ressing Ca(v)3.3, with Ki in a micromolar or submicromolar range.

281 the presence of hepcidin, with IC(50) in the submicromolar range.

282 r sensitivity to activation by Ca(2+) in the submicromolar range.

283 yed AC(50) values for PDK1 activation in the submicromolar range.

284 cooperatively with a binding constant in the submicromolar range.

285 n the physiologically relevant micromolar to submicromolar range.

286 e growth of the parasite with IC50 values in submicromolar range.

287 at inhibit ClpP1P2 peptidase activity in the submicromolar range.

288 Submicromolar-range activities were observed against wil

289 of detection for one of the systems reached submicromolar ranges (110 nM).

290 ics with respect to Ubc5 concentration, with submicromolar [S]0.5 and Hill coefficients of 3-5, sugge

291 Nevertheless, submicromolar S100A1 can alter RyR function, an effect t

292 re performed on both targets, resulting in a submicromolar (sEH IC50 = 0.3 muM/PPARgamma EC50 = 0.3 m

293 diates Ca(2+)-dependent Cl(-) transport with submicromolar sensitivity to Ca(2+), consistent with wha

294 The 1-Zn(II) NDP sensor assay offers submicromolar sensitivity, compatibility with both purif

295 n Ca(2+) signals differ vastly from the slow submicromolar signals routinely observed in bulk cytopla

296 New analogues have been identified with submicromolar SIRT2 inhibtory activity and good to excel

297 d X-ray crystallography, that high-affinity (submicromolar) substrate binding to the OM long-chain fa

298 tor, nonsuppressed detection permits LODs of submicromolar to double digit micromolar for a variety o

299 In cell culture, telaprevir showed submicromolar-to-low-micromolar potency against several

300 uctural optimization resulted in a lead with submicromolar VISTA binding affinity.