ライフサイエンスコーパス: submicroscopic

1 s) with one additional GSD I patient showing submicroscopic 6q14.1 deletion.

2 Viruses are submicroscopic agents that can infect other lifeforms an

3 togenetic anomaly of chromosome 7 revealed a submicroscopic allelic imbalance for a third distal locu

4 liposomes resulted in their conversion into submicroscopic alpha-gal nanoparticles.

5 ve been demonstrated to be the most frequent submicroscopic alterations in cytogenetically normal acu

6 ene (n = 8) and trisomy 8 (n = 3), recurrent submicroscopic alterations, including acquired uniparent

7 re 13.5% (range 0.0-55.9, 66 substudies) for submicroscopic and 8.0% (0.0-50.6, 66 substudies) for mi

8 is approach allowed us to detect and monitor submicroscopic and asymptomatic infections over a 4-year

9 blic health problem, and the contribution of submicroscopic and asymptomatic infections to its persis

10 There is a considerable burden of submicroscopic and asymptomatic malaria in malarious reg

11 However, many asymptomatic infections are submicroscopic and can only be detected by molecular met

12 gnancy were at significantly higher risks of submicroscopic and microscopic infections throughout pre

13 were highest in the first trimester for both submicroscopic and microscopic infections.

14 of gametocyte carriers are asymptomatic and submicroscopic and represent a challenge to malaria cont

15 died the dynamics of and factors influencing submicroscopic (and microscopic) P. falciparum infection

16 nt excitation lead to a method of creating a submicroscopic area of total internal reflection illumin

17 Because of submicroscopic bacteremia, microscopy can be insensitive

18 Moreover, submicroscopic BCAs and subarray threshold CNVs are intr

19 ion of Ag-containing membranes, formation of submicroscopic BCR oligomers, and recruitment and activa

20 , with the proportion of infections that are submicroscopic being highest in South American surveys a

21 villages, determined factors associated with submicroscopic carriage, and assessed the natural histor

22 indows, and bed net use were associated with submicroscopic carriage.

23 Over 4 weeks, 23% of submicroscopic carriers (61 of 266) became RDT positive,

24 When transmission reaches very low levels, submicroscopic carriers are estimated to be the source o

25 bmicroscopic reservoir and the likelihood of submicroscopic carriers developing patent malaria in coa

26 ssing 80% of participants, the proportion of submicroscopic carriers increased with decreasing villag

27 asymptomatic infections and 95.3% (41/43) of submicroscopic cases (<16 parasites/muL), outperforming

28 delineation of many previously unrecognized submicroscopic chromosomal aberrations (genomic disorder

29 isk variants and rarer more highly penetrant submicroscopic chromosomal deletions and duplications, k

30 d that the technique is capable of detecting submicroscopic chromosomal DNA deletions.

31 tools designed to aid the interpretation of submicroscopic chromosomal imbalance, inversions, and tr

32 Genomic mechanisms for these submicroscopic chromosomal rearrangements remain unknown

33 artificial chromosome microarray to identify submicroscopic chromosomal rearrangements specific to au

34 horts, of high-density microarray studies of submicroscopic chromosomal structure as well as high-thr

35 Submicroscopic chromosome 7q11.23 deletions cosegregate

36 found that the t(4;19) is associated with a submicroscopic chromosome duplication involving a 19p ch

37 croscopically detectable rearrangements, and submicroscopic copy-number variants (CNVs), which collec

38 The discovery of submicroscopic copy-number variations (CNVs) present in

39 ons vividly shows regions of microscopic and submicroscopic curvature of the membrane, and also gives

40 We report two submicroscopic de novo deletions of 11p13 that cause ani

41 A submicroscopic deletion containing SOX2 was identified a

42 This submicroscopic deletion is readily detected by fluoresce

43 with this inheritance pattern, 51 carried a submicroscopic deletion of 1q21.1 that has previously be

44 Neurofibromatosis type 1 patients with a submicroscopic deletion spanning the NF1 tumor suppresso

45 at the mutation is associated with a <170 kb submicroscopic deletion that includes the anonymous micr

46 Our data also suggest that submicroscopic deletion, but not large deletions, is the

47 3 GTS patients and 1571 control subjects for submicroscopic deletions and duplications of these four

48 marily because of its higher sensitivity for submicroscopic deletions and duplications.

49 ysis of 9 DS-ALL cases identified additional submicroscopic deletions in key genes, including ETV6, C

50 of HTX1 localization, a PCR-based search for submicroscopic deletions in this region was performed in

51 h mental retardation and overlapping de novo submicroscopic deletions of 15q24 (1.7-3.9 Mb in size).

52 ity or replication stress can generate large submicroscopic deletions of the type seen in cancer cell

53 ndrome is a rare genetic disorder, caused by submicroscopic deletions on chromosome 15q.

54 uffering from developmental disorders harbor submicroscopic deletions or duplications that, by affect

55 tu hybridization on cells from patients with submicroscopic deletions to narrow the candidate region

56 It is associated with visible or submicroscopic deletions within chromosome band 17p13.3.

57 rbored asexual stages, or had gametocytes at submicroscopic densities.

58 h histologically negative SLNs, detection of submicroscopic disease by tyrosinase RT-PCR does not def

59 that use methodologies capable of detecting submicroscopic disease can distinguish subgroups of pati

60 could improve prognostication by identifying submicroscopic disease during remission.

61 (2+) between active channels situated within submicroscopic distances amplified receptor inactivation

62 tudies establish MA-TIRFM for measurement of submicroscopic distances between fluorescent probes and

63 tware, pixel by pixel, generating a range of submicroscopic distances between QD pairs.

64 ctrons, was developed for the measurement of submicroscopic distances.

65 Over recent years small submicroscopic DNA copy-number variants (CNVs) have been

66 ndent spectral shifts; 2), identification of submicroscopic domains by fluorescence lifetime imaging

67 ly contribute to cAMP gradients occurring in submicroscopic domains.

68 transmembrane proteins into microscopic and submicroscopic domains.

69 identified seven unrelated individuals with submicroscopic duplication in 17p13.3 involving the PAFA

70 A submicroscopic duplication that contains the entire prot

71 Cryptic, submicroscopic duplications were observed at or near the

72 in whole organisms, tissues, organelles, and submicroscopic environments in which measurements were p

73 These differences in submicroscopic epidemiology potentially warrant differen

74 elation between the outcome of treatment and submicroscopic evidence of residual disease.

75 Thirteen percent to 23% of clones exhibited submicroscopic FHIT deletions spanning approximately 200

76 Acute leukemia genomes commonly harbor submicroscopic gains and deletions of DNA which target k

77 transmission is much less likely to occur at submicroscopic gametocyte levels.

78 pants were infected three or more times, and submicroscopic gametocyte prevalence was high, 48% of th

79 These studies have identified cryptic or submicroscopic genetic alterations that define new ALL s

80 Multiple submicroscopic genetic alterations with prognostic signi

81 Multiple submicroscopic genetic alterations with prognostic signi

82 of aneuploidy, transcriptional profiles and submicroscopic genetic alterations.

83 d called EigenDel for detecting the germline submicroscopic genomic deletions.

84 rs are the clinical conditions manifested by submicroscopic genomic rearrangements including copy num

85 Submicroscopic gold particle suspensions scatter colored

86 Secretory cells contain submicroscopic granules composed of a polyanionic polyme

87 nges allow for the routine identification of submicroscopic imbalances in large numbers of patients.

88 lciparum and 87% of P. vivax infections were submicroscopic in 2014.

89 high burden of infections was identified as submicroscopic in Rourkela (45%, 42 infections) and Chen

90 We aimed to explore potential drivers of submicroscopic infection and to identify the locations w

91 Significant variation in the prevalence of submicroscopic infection exists even across settings cha

92 c structure of the infected population (with submicroscopic infection more likely to occur in adults

93 in low transmission settings, but drivers of submicroscopic infection remain unclear.

94 thirds of PCR-positive individuals harboring submicroscopic infection.

95 doses was not associated with the number of submicroscopic infections (aIRR = 1.2, P = .543).

96 doses was not associated with the number of submicroscopic infections (aIRR=1.2, p=0.543).

97 Risk factors for submicroscopic infections among women with NAAT-positive

98 ming of interventions, which need to include submicroscopic infections and be implemented in the dry

99 in patients with early-stage malaria and/or submicroscopic infections and could greatly benefit mala

100 enabling improved detection of asymptomatic submicroscopic infections and dramatic savings in labor

101 fects on the proportions of asymptomatic and submicroscopic infections and on transmission potential

102 During pregnancy, submicroscopic infections are more common than microscop

103 nfection and to identify the locations where submicroscopic infections are most common.

104 Prospectively, submicroscopic infections at inclusion were associated w

105 Molecular methods can detect submicroscopic infections but have not hitherto been ame

106 ber of P. falciparum infections, focusing on submicroscopic infections detectable only by PCR.

107 ber of P. falciparum infections, focusing on submicroscopic infections detectable only by PCR.

108 to assess prevalence of and risk factors for submicroscopic infections during pregnancy and at delive

109 ies with information on both microscopic and submicroscopic infections during pregnancy from Asia, th

110 Submicroscopic infections during pregnancy were associat

111 asites and shows promise as a tool to detect submicroscopic infections in malaria control and elimina

112 To eliminate malaria, surveillance for submicroscopic infections is needed.

113 Quantifying these submicroscopic infections is therefore key to understand

114 ificant influence of seasonality, with fewer submicroscopic infections observed in the wet season tha

115 variate analyses, we evaluated the impact of submicroscopic infections on maternal anemia, premature

116 Our results show that submicroscopic infections predominate in low-transmissio

117 arasite density suggests the contribution of submicroscopic infections to transmission across differe

118 tion tests (NAATs), the median proportion of submicroscopic infections was 58.7% (range 0.0-100); thi

119 proportional high burden of asymptomatic and submicroscopic infections was detected in community surv

120 women with no malaria infections, those with submicroscopic infections were more likely to present wi

121 ng river levels and increasing rainfall, but submicroscopic infections, detected by qPCR, were perenn

122 were employed to detect both microscopic and submicroscopic infections, respectively.

123 protection against P. falciparum, especially submicroscopic infections.

124 by microscopy to identify microscopic versus submicroscopic infections.

125 ificantly more common among microscopic than submicroscopic infections.

126 pregnancy should target both microscopic and submicroscopic infections.

127 Most infections before pregnancy were submicroscopic infections.

128 protection against P. falciparum, especially submicroscopic infections.

129 ominent roles for infections in children and submicroscopic infections.

130 e considered differences in estimates due to submicroscopic infections.

131 logical factors associated with low-density, submicroscopic infections.

132 -reducing interventions require knowledge of submicroscopic infectious reservoirs among asymptomatic

133 1 deletion resulted from a maternal balanced submicroscopic insertional translocation of the entire P

134 associated gene rearrangements in tumors are submicroscopic, intralocus deletions of hundreds of kilo

135 current chromosome macrorearrangements and a submicroscopic inversion polymorphism.

136 All the mothers were heterozygous for an 8p submicroscopic inversion that was delimited by the 8p-OR

137 eatment response assessed by measurements of submicroscopic leukaemia (minimal residual disease) has

138 e investigated retrospectively the impact of submicroscopic leukemia on outcome in 64 patients receiv

139 mu, and pfubp1 more often survive ACT at the submicroscopic level, and contribute to onward transmiss

140 The clinical significance of submicroscopic levels of leukaemic cells in bone-marrow

141 Even submicroscopic levels of Plasmodium falciparum gametocyt

142 a companion article we present the idea that submicroscopic light-scattering particles, such as gold

143 chor on a protein is sufficient to determine submicroscopic localization within the plasma membrane.

144 llite markers enabling the identification of submicroscopic losses.

145 2-based applications, including detection of submicroscopic malaria and diagnosis of severe malaria.

146 The relationships between submicroscopic malaria and subsequent microscopically de

147 On the Thailand-Myanmar border, submicroscopic malaria at first antenatal consultation w

148 dertaken to investigate associations between submicroscopic malaria at the first antenatal care (ANC)

149 there is some evidence that individuals with submicroscopic malaria can infect mosquitoes, transmissi

150 should strive to define the degree to which submicroscopic malaria contributes to the infectious res

151 The weighted proportion of women with submicroscopic malaria infection was 4.6% (95% CI 3.9-5.

152 We aimed to describe the epidemiology of submicroscopic malaria infections in pregnant women in A

153 Results identified 54 asymptomatic submicroscopic malaria infections, including a large clu

154 arriage, and assessed the natural history of submicroscopic malaria over 4 weeks.

155 rth, but the effects of lower density (i.e., submicroscopic) malaria infections are poorly characteri

156 The use of an RT-PCR assay for detection of submicroscopic melanoma metastases in SLNs improved the

157 alf was submitted for molecular detection of submicroscopic metastases using a reverse transcriptase-

158 ng 353 inhabitants enrolled, a ratio of 17:1 submicroscopic/ microscopic malaria infections.

159 uring the past 2 decades, and measurement of submicroscopic (minimal) levels of residual disease (MRD

160 an image-like spatial map of the rapidity of submicroscopic motions of scattering centers.

161 ome lipid mixtures form membranes containing submicroscopic (nanodomain) ordered lipid domains (rafts

162 Low-density infections are often submicroscopic, not detected with rapid diagnostic tests

163 identification of additional cell lines with submicroscopic or larger deletions of the locus which oc

164 ared to 25.0% (248/992) of participants with submicroscopic or no parasitemia (odds ratio [OR] 0.25,

165 und that those of young age and those with a submicroscopic P. falciparum infection prior to pregnanc

166 The incidence rate of submicroscopic P. falciparum infections during pregnancy

167 Submicroscopic P. falciparum mono-infection (adjusted HR

168 study, we document the deleterious impact of submicroscopic P. falciparum parasitemia during pregnanc

169 atic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population.

170 A considerable proportion of submicroscopic P. vivax infections resolved spontaneousl

171 with increased risk of maternal anaemia, but submicroscopic P. vivax mono-infection was not.

172 We identified submicroscopic PAR1 deletions encompassing the recently

173 Submicroscopic parasitaemia at first ANC visit was assoc

174 participants of cohort 2 developed transient submicroscopic parasitaemia.

175 We show that submicroscopic parasite carriage is common in adults, in

176 are unable to characterize the complexity of submicroscopic parasite dynamics, particularly in high t

177 Residual submicroscopic parasitemia is common after ACT and is as

178 Participants with submicroscopic parasitemia were at a lower risk of gamet

179 Participants with PCR-positive, submicroscopic parasitemia were followed in subsequent s

180 hose with parasitemia detected by PCR alone (submicroscopic parasitemia) (6.1 U/g Hb, IQR 4.8-8.6, p

181 lacental malaria remain asymptomatic or have submicroscopic parasitemia, masking the association betw

182 s associated with control of microscopic and submicroscopic parasitemia.

183 In addition, submicroscopic particles which scatter blue, green, yell

184 298 ACT-treated children from Mbita, Kenya, submicroscopic persistence of P. falciparum on day 3 pos

185 To characterize submicroscopic Plasmodium falciparum carriage in an area

186 efforts, special attention is being paid to submicroscopic Plasmodium falciparum infections.

187 malaria in pregnancy, mainly with respect to submicroscopic Plasmodium falciparum infections.

188 widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknow

189 ical features, and also in less visualizable submicroscopic regions of activity such as endocytosis,

190 level appears to affect both the size of the submicroscopic reservoir and the likelihood of submicros

191 d to explore determinants of the size of the submicroscopic reservoir including geographical location

192 The extent of the submicroscopic reservoir needs to be taken into account

193 We investigated the size of the submicroscopic reservoir of infection across villages, d

194 nts a crucial determinant of the size of the submicroscopic reservoir, as does the demographic struct

195 r lipid membranes (SLM) have been studied at submicroscopic resolution using atomic force microscopy

196 structural alterations in these regions at a submicroscopic scale.

197 ntial number of P. vivax recurrences, mainly submicroscopic (SM) and asymptomatic, were observed afte

198 alterations in ALL have identified multiple submicroscopic somatic mutations targeting key cellular

199 tically heterogeneous and porous matter with submicroscopic spatial resolution in aqueous solution.

200 plasma membrane are known to partition into submicroscopic sphingolipid- and cholesterol-rich domain

201 and leukaemic cell DNA has identified novel submicroscopic structural genetic changes and sequence m

202 stigated the prevalence and the landscape of submicroscopic structural variants (SVs) at single-base

203 revealed subcellular heterogeneities in the submicroscopic structure of cytoplasm.

204 unclear whether the remaining patients have submicroscopic systemic disease and, if so, what is the

205 dium vivax infections were more likely to be submicroscopic than Plasmodium falciparum infections (3.

206 g constants of these helices depend on their submicroscopic thickness.

207 Submicroscopic vesicles produced using extrusion are wid

208 es (pcTALM), complex assembly within dynamic submicroscopic zones was identified.