ライフサイエンスコーパス: subnuclear

1 he PVTD did not associate with several known subnuclear addresses but was almost always perinucleolar

2 We monitored Smc5/6 subnuclear and genomic localization in response to diffe

3 target gene regulatory enhancer regions to a subnuclear architectural structure that serves as an und

4 These changes in subnuclear architecture and cell cycle progression may b

5 the nucleolus in spermatocytes, implicating subnuclear architecture in the regulation of terminal di

6 that it interacts with proteins involved in subnuclear architecture, notably nucleophosmin, a 38-kDa

7 ulated the focal accumulation of Pin1 in the subnuclear area, which recruited Runx2.

8 myelinated fibers, we were able to correlate subnuclear areas in the mouse habenula to subnuclei, whi

9 A1 mutation in SNU-251 cells inhibited BRCA1 subnuclear assembly for DNA-damage repair and increased

10 ein transduction domain 4 (PTD4)], inhibited subnuclear assembly of RAD51 recombinase, and sensitized

11 f any one of the five paralog genes prevents subnuclear assembly of recombinase at damaged sites and

12 on by circumventing its requirement in RAD51 subnuclear assembly.

13 Within nuclei, HYL1 is associated with subnuclear bodies and ring-like structures.

14 ly exported to the cytoplasm and retained in subnuclear bodies called paraspeckles.

15 EAT1 (Menepsilon/beta) to form paraspeckles, subnuclear bodies that alter gene expression via the nuc

16 ge in liquid-liquid phase separation to form subnuclear bodies, as well as by acting as bridging fact

17 PML-like subnuclear bodies, containing XRCC1, juxtaposed to DNA r

18 Here we report that a subnuclear body called the interleukin-6 and -10 splicin

19 from either end of the dimer for paraspeckle subnuclear body formation.

20 B demonstrates the importance of this unique subnuclear body in restricting the monoallelic expressio

21 urons adopt medial (dHbm) and lateral (dHbl) subnuclear character at very different frequencies on th

22 Recently, it has been suggested that subnuclear chromatin compartmentalization might result f

23 ations in chromatin structure and changes in subnuclear chromatin localization in regulating var gene

24 iae found that this local silencing required subnuclear clustering of the tRNA genes near the nucleol

25 RNA polymerase II promoters is dependent on subnuclear clustering of the tRNA genes, but genetic ana

26 revealed that AGO4 and AGO6 differ in their subnuclear co-localization with RNA polymerases required

27 A large number of proteins found in this subnuclear compartment have no identifiable tie either t

28 of how and why these proteins end up in this subnuclear compartment remain unanswered and are the foc

29 , large-scale chromosome folding involving a subnuclear compartment switch of inaccessible chromatin.

30 ing that the Barr body represents a discrete subnuclear compartment that is not freely accessible to

31 RAG-1-RAG-2 complex nucleates a specialized subnuclear compartment that we call the 'V(D)J recombina

32 e neuroblast nuclear periphery, a repressive subnuclear compartment, precisely when competence to spe

33 A polymerase-II also colocalized in the same subnuclear compartment.

34 A structure, specific histone modifications, subnuclear compartmentalization and primary DNA sequence

35 These data suggest that subnuclear compartmentalization enables cyclin D3 to dri

36 smic signal transduction, nuclear import and subnuclear compartmentalization, DNA repair, and transcr

37 Consistent with different subnuclear compartments and functions, distinct domains

38 LocNuclei predicts subnuclear compartments and traveler proteins accurately

39 Coilin protein scaffolds Cajal bodies (CBs)-subnuclear compartments enriched in small nuclear RNAs (

40 be a subset of global NER, restricted to the subnuclear compartments or chromatin domains within whic

41 otein (PML) nuclear bodies (NBs) are dynamic subnuclear compartments that play roles in several cellu

42 ns in vivo is their appropriate targeting to subnuclear compartments where their target genes are loc

43 chromatin modifiers, formation of RNA-based subnuclear compartments, and regulation of transcription

44 late the disposition of FOXP3 into different subnuclear compartments, leading to enhanced chromatin b

45 an accurate partitioning of the genome into subnuclear compartments, with active euchromatin enriche

46 the target gene ensemble reside in distinct subnuclear compartments.

47 hin 1 h, and they were targeted to different subnuclear compartments.

48 due to the presence of chromatin domains and subnuclear compartments.

49 it associates with DCL3 and AGO4 in distinct subnuclear compartments.

50 n the nucleolus and the expression site body subnuclear compartments.

51 ults in a rapid increase in the formation of subnuclear complexes containing Rad51.

52 ence loss in photobleaching experiments show subnuclear concentrations of MCM-chromatin interactions

53 this study in the C57BL/6J mouse provides a subnuclear cytoarchitectonic parcellation (Nissl stain)

54 g nuclear mechanics do not provide access to subnuclear deformation in live functioning cells.

55 on genotoxic damage, which may modulate APE1 subnuclear distribution and enzymatic activity in vivo.

56 Their subnuclear distribution and interactions with AT-rich DN

57 and coimmunoprecipitation to examine how the subnuclear distribution and protein-protein interactions

58 artmentalized inside of the nucleus, and its subnuclear distribution depends on SIRT1.

59 ll accumulate in the nucleus, although their subnuclear distribution is altered.

60 attern, and coexpression of PDX-1 alters the subnuclear distribution of PCIF1.

61 speckles, indicating a shift from the normal subnuclear distribution of poly(A) RNA.

62 d at the nuclear periphery, we evaluated the subnuclear distribution of recombination-activating gene

63 SOX9-transfected COS-7 cells showed that the subnuclear distribution of SOX9 became more diffuse in t

64 ubc-9(RNAi) also alters the subnuclear distribution of TBX-2::GFP fusion protein, su

65 The subnuclear distribution of TEX1 substantially overlaps w

66 es between monosynaptic and PRV cases in the subnuclear distribution or proportions of retrogradely l

67 the absence of stimuli, ASP shows polarized subnuclear distribution, preferentially in areas with lo

68 s with phosphorylated c-Jun and alters c-Jun subnuclear distribution.

69 sulted in prolonged retention of DDB2 at the subnuclear DNA damage foci within micropore irradiated c

70 family, is concentrated in the nucleolus, a subnuclear domain disparate from the sites of mRNA trans

71 or interchromatin granule clusters (IGCs), a subnuclear domain enriched in pre-mRNA processing factor

72 n as the protein marker of the Cajal body, a subnuclear domain important to the biogenesis of small n

73 locytic leukemia protein (PML) and Daxx in a subnuclear domain, nuclear domain 10 (ND-10), when ectop

74 cation of phytochromes from the cytoplasm to subnuclear domains called photobodies and the degradatio

75 loci physically interacting with particular subnuclear domains could be readily identified.

76 Cajal bodies (CBs) are subnuclear domains implicated in small nuclear ribonucle

77 s the marker protein for Cajal bodies (CBs), subnuclear domains important for the biogenesis of small

78 Runx2, through its PY motif, recruits YAP to subnuclear domains in situ and to the osteocalcin (OC) g

79 Cajal bodies (CBs) are prominent interacting subnuclear domains involved in a number of crucial aspec

80 Cajal bodies (CBs) are subnuclear domains involved in the formation of ribonucl

81 ntly, recruitment of the YAP co-repressor to subnuclear domains is abrogated and expression of the en

82 ompensation, providing new insights into how subnuclear domains of coordinate gene regulation are for

83 Nuclear speckles are subnuclear domains that contain pre-mRNA processing fact

84 leus is compartmentalized into nonmembranous subnuclear domains that regulate key nuclear functions.

85 nuclear environment, but no accumulation at subnuclear domains was observed.

86 hysical location of these damages within the subnuclear domains, determined the cellular ability to r

87 phingolipid species are localized in various subnuclear domains, including chromatin, the nuclear mat

88 encapsidated by HPV16 from reaching the ND10 subnuclear domains.

89 actions within complexes located in separate subnuclear domains.

90 s directs these factors to their appropriate subnuclear domains.

91 other protein components of CBs and related subnuclear domains; however, only a few have examined in

92 he BRC repeat expansion is crucial for RAD51 subnuclear dynamics after DNA damage.

93 AD(+) metabolism in the nucleus is linked to subnuclear dynamics of active SIRT1.

94 s act in DNA repair, recombination and RAD51 subnuclear dynamics, though not equivalently, while muta

95 and anabolic functions of osteoblasts as the subnuclear effector of multiple signaling axes (e.g. tra

96 chromatin at DSBs establishes an accessible subnuclear environment that facilitates DNA damage signa

97 tional group of genes, suggesting that these subnuclear environments are not organized to respond to

98 Subnuclear environments at the nuclear periphery promote

99 Such subnuclear environments have significant implications fo

100 gle-expresser cells, predominantly contain 1 subnuclear ESB, as determined using Pol I or the ESB mar

101 ifferent families colocalize within the same subnuclear expression site, indicating that the role tha

102 and p220 are targeted to, and colocalize at, subnuclear foci (Cajal bodies) in a cell cycle-dependent

103 colocalize at histone gene loci in dedicated subnuclear foci (histone locus bodies) that are distinct

104 replication machinery localize into discrete subnuclear foci after DNA damage, where they play requis

105 XopD colocalized with SlERF4 in subnuclear foci and catalyzed SUMO1 hydrolysis from lysi

106 activation of TAF1, ATR rapidly localized to subnuclear foci and contributed to the phosphorylation o

107 In addition, PRR5 recruits TOC1 to large subnuclear foci and promotes phosphorylation of the TOC1

108 report that 1) Sp2 localizes largely within subnuclear foci associated with the nuclear matrix, and

109 ut blocking RAD51's ability to assemble into subnuclear foci at sites of DNA damage.

110 ceptors, phytochromes, from the cytoplasm to subnuclear foci called phytochrome nuclear bodies.

111 he chromodomains target proteins to specific subnuclear foci coincident with heterochromatin.

112 tant was also compromised for forming stable subnuclear foci in living cells.

113 various fluorescent derivatives form similar subnuclear foci in plant cells and that homologous inter

114 ed processes, BLAP75 colocalizes with BLM in subnuclear foci in response to DNA damage, and its deple

115 mage-induced recruitment of Nse4 and Smc5 to subnuclear foci in vivo.

116 ERCC1 translocation to DNA damage-induced subnuclear foci is markedly impaired in USP45 knockout c

117 s its redistribution from the cytoplasm into subnuclear foci known as photobodies (PBs), which dissip

118 e gene-specific transcription factor NPAT in subnuclear foci, including Cajal bodies that associate w

119 ing hinge region also prevented formation of subnuclear foci, structures potentially important for ep

120 ding FANCD2, BRCA1 and RAD51, to MMC-induced subnuclear foci.

121 promoting the proper assembly of HR-directed subnuclear foci.

122 e required for N and P colocalization in the subnuclear foci.

123 where it colocalized with the proteasome in subnuclear foci.

124 -related modifier 1 (SUMO1) was localized to subnuclear foci.

125 ly with CDK8 and can cause it to localize to subnuclear foci.

126 heavily targeted host protein colocalized in subnuclear foci.

127 sically and partially colocalize at discrete subnuclear foci.

128 Using the subnuclear fractionation assay, we further demonstrated

129 Subnuclear fractionation showed PELP1 association with c

130 ntified by Western blot analyses in purified subnuclear fractions (e.g., nucleoli and nuclear matrix)

131 Subnuclear functions are regulated by controlling the su

132 roblasts undergo a developmentally regulated subnuclear genome reorganization to permanently silence

133 lvinar and the mediodorsal nucleus displayed subnuclear heterogeneity in their driver assemblies.

134 Trm1p-II N-acetylation is necessary for its subnuclear INM location.

135 that might contribute to the characteristic subnuclear KSHV microdomains ("LANA speckles"), a hallma

136 lable, we established nuclear morphology and subnuclear localisation.

137 ed COS-1 cells, the RD3-fusion protein shows subnuclear localization adjacent to promyelocytic leukem

138 p60/Hop with AF9 is necessary for the proper subnuclear localization and activity of AF9.

139 MeCP2-e1 differed from the bulk of MeCP2 in subnuclear localization and co-factor interaction.

140 research addresses the relationship between subnuclear localization and gene expression in fission y

141 HDA15 phosphorylation status determines its subnuclear localization and oligomerization.

142 y on the Msx1 homeoprotein by regulating its subnuclear localization and proximity to target genes.

143 sine 9 of histone H3 (MeK9H3) to examine the subnuclear localization and replication timing of chroma

144 lf-life of NPHP7/Glis2, but also altered the subnuclear localization and the transcriptional activity

145 issing its C-terminal domain restores normal subnuclear localization and toxicity in C. elegans and C

146 However, the precise subnuclear localization and transport of vRNPs remain un

147 AR2 differ in both their ability to modulate subnuclear localization as well as to promote site-selec

148 f abolish self-interaction or cause aberrant subnuclear localization but do not abolish interaction w

149 nsive alterations to chromatin structure and subnuclear localization have been shown to play key role

150 negative charges from HEXIM1 results in its subnuclear localization into nuclear speckles.

151 Moreover, we show that CESTA subnuclear localization is BR regulated and discuss a mo

152 eat in the N-terminus of the RS domain while subnuclear localization is controlled by phosphorylation

153 functions, and suggest that its nuclear and subnuclear localization is highly dependent on direct or

154 marrow blasts in 3 patients and restored the subnuclear localization of both NPM1 and PML.

155 romoter by C/EBP beta-1 without altering the subnuclear localization of C/EBP beta-1.

156 hromosomal organizational structures and the subnuclear localization of chromosomes as they relate to

157 ay muscle-specific defects linked to altered subnuclear localization of heterochromatin, leading to a

158 site mutations affected the subcellular and subnuclear localization of ICP0, its ability to alter th

159 s numerous cellular functions, including the subnuclear localization of its target proteins.

160 tightly correlated with phosphorylation and subnuclear localization of retinoblastoma protein (Rb).

161 We report here the differential subnuclear localization of RNA strands of opposite polar

162 etermine signals controlling the nuclear and subnuclear localization of the 18-kDa FGF-2, its full-le

163 ynamics during elongation or disruption, the subnuclear localization of the MUC4 loci, the cohesion o

164 r functions are regulated by controlling the subnuclear localization of the nuclear proteins.

165 trafficking within the cell, we analysed the subnuclear localization of wild-type and mutant p53 in h

166 H2AX phosphorylation to DNA damage and their subnuclear localization to DNA damage sites.

167 Disruption of Runx1/AML1 subnuclear localization, either by a single amino acid s

168 Analysis of subnuclear localization, gene expression, and chromatin

169 use embryonic stem cells and measuring their subnuclear localization, genomic distribution and histon

170 ological activity of Runx2, dependent on its subnuclear localization, in promoting early events of br

171 been reported to regulate their activity and subnuclear localization.

172 uggesting that ERK may regulate TRAP220/Med1 subnuclear localization.

173 mation via mechanisms that do not compromise subnuclear localization.

174 he mRNA splicing factor SRSF2 and alters its subnuclear localization.

175 hylation of H3K9 and H3K27 and disruption of subnuclear localization.

176 ow to high mobility and displaying different subnuclear localizations patterns.

177 e, replication origins occupy characteristic subnuclear localizations that anticipate their initiatio

178 ins (SIRT1, SIRT6, and SIRT7) show different subnuclear localizations: SIRT6 and SIRT7 are associated

179 Furthermore, we report that the subnuclear-localized EXC-7 protein, the C. elegans ortho

180 We assessed the subnuclear location finding a widespread distribution of

181 Max was recruited to different subnuclear locations by interactions with Myc versus Mad

182 hen expressed alone but was relocalized to a subnuclear locus when coexpressed with the MFSV N protei

183 sor protein that is associated with distinct subnuclear macromolecular structures called the PML bodi

184 Many brain regions contain subnuclear microarchitectures, such as the matrix-strios

185 atin-remodeling events and rapid assembly of subnuclear microenvironments that activate histone gene

186 gerin sequesters NRF2 and thereby causes its subnuclear mislocalization, resulting in impaired NRF2 t

187 eplication, and is associated with decreased subnuclear mobility of the locus.

188 on and suggests that additional steps (i.e., subnuclear mobilization or uncoating) limit successful A

189 tal regulator relocalizes a locus into a new subnuclear neighborhood that is permissive for high leve

190 The nucleolus has begun to emerge as a subnuclear organelle capable of modulating the activitie

191 The nucleolus is a subnuclear organelle in which rRNAs are transcribed, pro

192 The nucleolus is the subnuclear organelle responsible for rRNA synthesis, pro

193 biogenesis that takes place in a distinctive subnuclear organelle, the nucleolus.

194 The morphology and composition of subnuclear organelles, such as Cajal bodies (CBs), nucle

195 mb bodies, and paraspeckles are membraneless subnuclear organelles.

196 lear components including nuclear lamina and subnuclear organelles.

197 They provide new insights into subnuclear organization and chromosome biology, and, alt

198 potential center of an "anti-reward system." Subnuclear organization and connectivity of the LHb are

199 Subnuclear organization and spatiotemporal regulation of

200 affects gene regulation by facilitating the subnuclear organization of chromatin.

201 ohesin network play an important role in the subnuclear organization of chromatin.

202 In this study, we use the subnuclear organization of factors controlling histone g

203 ropose that Son is essential for appropriate subnuclear organization of pre-mRNA splicing factors and

204 revealing some interesting insights into the subnuclear organization of RNA processing machineries am

205 In contrast, subnuclear organization of SC35 is restored subsequent t

206 formation is prohibited by the fact that the subnuclear organization of the habenular complexes in mo

207 us and provide a model for understanding the subnuclear organization of tissue-specific regulatory pr

208 ells treated with hinokiflavone show altered subnuclear organization specifically of splicing factors

209 The subnuclear origin of LHb inputs to the VTA and RMTg was

210 cript 1 (NEAT1), which forms the backbone of subnuclear "paraspeckle" bodies, has been identified as

211 based on massive-throughput RNA barcoding of subnuclear particles in water-in-oil emulsion droplets,

212 resent in the nucleus, where it localizes to subnuclear particles.

213 role of SUMO binding in this context is the subnuclear partitioning of the active form of Ubc9 (SUMO

214 proteins form foci located partially at the subnuclear periphery.

215 portant signaling roles by targeting PHYB to subnuclear photobodies and interacting with PIF3 to trig

216 We also observed that E1B-55K lacking subnuclear PML localization because of either PML-IV or

217 Moreover, cohesin defects compromise the subnuclear position of chromatin.

218 wever, G9a loss did not significantly affect subnuclear position or replication timing of any non-per

219 tional maintenance did not restore the locus subnuclear position that preceded activation.

220 th transcriptional competence and changes in subnuclear position.

221 n signal sequences, and regulated changes in subnuclear positioning may influence locus recombination

222 "territories" and undergo dynamic changes in subnuclear positioning.

223 s: 16 of 21 repressors blocked Put3-mediated subnuclear positioning; 11 of these required Rpd3.

224 inactive X chromosomes localize to different subnuclear positions and adopt distinct chromosomal arch

225 l DNA to the nucleus and subsequently to the subnuclear promyelocytic leukemia protein bodies, sugges

226 etinopathy-associated RD3 protein is part of subnuclear protein complexes involved in diverse process

227 rrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing

228 cue unc-75 mutant phenotypes and localize to subnuclear puncta.

229 ngly, the molecule inhibits the formation of subnuclear RAD51 foci in cells following DNA damage, whi

230 teins was reduced and this correlated with a subnuclear redistribution.

231 ins associated with nucleosomes in different subnuclear regions in both ES cells and fibroblasts.

232 stered binding sites in spatially restricted subnuclear regions, suggesting that topological structur

233 nals are anatomically restricted to distinct subnuclear regions.

234 te cellular protein functions in addition to subnuclear relocalization.

235 end-joining (NHEJ) processes in specialized subnuclear repair centres; cells have a broad variety of

236 C inhibition caused a complete inhibition of subnuclear repair foci in response to ionizing radiation

237 , is shown biochemically and through FRET in subnuclear repair foci.

238 cellular nucleolar protein nucleolin in the subnuclear replication compartments in which viral DNA r

239 nuclear PI3K signaling, which regulates its subnuclear residency, cell proliferation, and mRNA expor

240 Here, we show that 116HG forms a subnuclear RNA cloud that co-purifies with the transcrip

241 required for the concentration of BFRF3 at a subnuclear site and the N-terminal 65 amino acids contai

242 association of Tax with this multifunctional subnuclear site results in disruption of a subset of the

243 ntial activities, the FBPs traffic to shared subnuclear sites and regulate many common target genes,

244 ch dynamically localize to different defined subnuclear sites during wild-type prophase progression t

245 on of Runx2-YAP transcriptional complexes at subnuclear sites to attenuate skeletal gene expression.

246 riptase (hTERT), are recruited from distinct subnuclear sites to telomeres during S phase.

247 s necessary and sufficient to target AML1 to subnuclear sites.

248 novel evidence of the in vivo occurrence and subnuclear spatial localization of both exogenously expr

249 populations that target the IP with variable subnuclear specificity.

250 ligase correlated with targeting of Smad4 to subnuclear speckles that contain SUMO-1 and PIASy.

251 F65, creates Tat inhibitors that localize to subnuclear speckles, sites where pre-mRNA processing fac

252 iana OXS3 proteins in plant cells revealed a subnuclear speckling pattern related to the nucleosome i

253 vels in a "goldilocks" region for the proper subnuclear storage of an SR protein splicing factor.

254 and only when DNA damage was concentrated in subnuclear stripes, generated by partially shielded ultr

255 lular functions, such as gene transcription, subnuclear structure formation, viral infection, and cel

256 directly address the neuronal roles of this subnuclear structure have appeared only recently.

257 staged assembly and modification of a unique subnuclear structure that coordinates initiation and pro

258 e a molecular pathway linking the actions of subnuclear structure-specific ncRNAs and nonhistone prot

259 WTX is present in distinct subnuclear structures and co-localizes with the paraspec

260 Therefore, there are modality-specific subnuclear structures in the posterior thalamus, but les

261 e formation of replication compartments, the subnuclear structures in which the viral DNA genome is r

262 3D configuration and chemical composition of subnuclear structures of pyramidal cells in the CA2 regi

263 leukemia nuclear bodies (PML-NBs), which are subnuclear structures required for the development of a

264 nd the nucleus, where it concentrates in two subnuclear structures termed Cajal body (CB) and gems.

265 s of proteins, which associate with specific subnuclear structures, is critical to understanding euka

266 hysical link between the plasma membrane and subnuclear structures.

267 L nuclear bodies and recruits APC/C to these subnuclear structures.

268 recruitment of proteins in and out of these subnuclear structures.

269 mobility of SUMO paralogues differed between subnuclear structures.

270 ncluding Polycomb group (PcG) proteins, form subnuclear structures.

271 wash mutant and knockdown nuclei disrupt subnuclear structures/organelles and exhibit the abnorma

272 We therefore addressed the relevance of AML1 subnuclear targeting and associated functions that resid

273 aining DNA binding activity, display loss of subnuclear targeting and associated transactivation func

274 Thus, we demonstrate that the subnuclear targeting and transcriptional regulatory acti

275 ation of a RUNX2-SMAD osteogenic complex and subnuclear targeting are structurally and functionally i

276 ssor in primary diploid osteoblasts and that subnuclear targeting contributes to Runx2-mediated tumor

277 A subnuclear targeting deficient mutant Runx2, which disru

278 Here, we show that proper Runx2 subnuclear targeting is required for osteolysis.

279 minus of AML1 with the ETO protein, modifies subnuclear targeting of AML1 in acute myeloid leukemia (

280 and that Tat is involved in the nuclear and subnuclear targeting of PP1.

281 We have summarized evidence that subnuclear targeting of transcription factors mechanisti

282 pin RNA-Runx2 or a mutant Runx2 deficient in subnuclear targeting resulted in reversion of acini to m

283 ch also include the transcriptionally active subnuclear targeting sequence (376 to 432).

284 lear localization was introduced in the AML1 subnuclear targeting signal.

285 These findings functionally link AML1 subnuclear targeting with competency for myeloid differe

286 The dsRBMs of ADAR2 are interchangeable for subnuclear targeting, yet such motif alterations do not

287 Reintroduction of WT Runx2, but not a subnuclear targeting-defective mutant, induces both p21(

288 in Tax specific for nuclear localization and subnuclear targeting.

289 signal of Runx factors and exhibits reduced subnuclear targeting.

290 This subnuclear territory thus represents an intermediate reg

291 in many areas of physics and chemistry from subnuclear to astronomic length scales.

292 anial motor neuron positioning and establish subnuclear topography and motor function.

293 e developed a previously undescribed in situ subnuclear trafficking assay that generates transcriptio

294 ar chaperone involvement in steroid receptor subnuclear trafficking was provided by the ATP-dependent

295 rritories and the functional significance of subnuclear transitions.

296 ndings suggest that CLUH plays a role in the subnuclear transport of progeny vRNP.

297 ization to the nucleoplasm and disrupted the subnuclear transport of vRNP, abolishing vRNP nuclear ex

298 ot well established, plays a key role in the subnuclear transport of vRNP.

299 ax TSLS mutant rescued the nuclear entry and subnuclear TSS targeting of both proteins, demonstrating

300 xpression of N and P results in formation of subnuclear viroplasm-like foci.