ライフサイエンスコーパス: substitution reaction

1 a)-C(delta) bond in 3 and complete the gamma-substitution reaction.

2 ted to the morpholino group through a simple substitution reaction.

3 beled with (18)F using aromatic nucleophilic substitution reaction.

4 diastereoselective palladium-catalyzed azide substitution reaction.

5 as prepared by D-A addition, hydrolysis, and substitution reaction.

6 ified as an "inverse-electron-demand" ligand-substitution reaction.

7 sky reaction followed by a nucleophilic acyl substitution reaction.

8 e OH- + CH3F --> CH3OH + F- SN2 nucleophilic substitution reaction.

9 e the possibility of a nucleophilic aromatic substitution reaction.

10 ate with the proposed electrophilic aromatic substitution reaction.

11 neously activated to effect a stereospecific substitution reaction.

12 olabeling was accomplished by a nucleophilic substitution reaction.

13 bifunctional catalyst in the intramolecular substitution reaction.

14 -exo-trig cyclization/electrophilic aromatic substitution reaction.

15 ic understanding of cuprate-mediated allylic substitution reactions.

16 equence of one-electron reduction and ligand substitution reactions.

17 sunobu, oxidation, reduction, acylation, and substitution reactions.

18 kinetically controlled nucleophilic aromatic substitution reactions.

19 the superiority of organocuprates in allylic substitution reactions.

20 oup in COP-catalyzed enantioselective S(N)2' substitution reactions.

21 of nucleophiles with applications in allylic substitution reactions.

22 itutions at boron and electrophilic aromatic substitution reactions.

23 o found to undergo very facile electrophilic substitution reactions.

24 vity in iridium-catalyzed asymmetric allylic substitution reactions.

25 ent for substrate activation in nucleophilic substitution reactions.

26 remely reactive with respect to nucleophilic substitution reactions.

27 astereoselectivity results from nucleophilic substitution reactions.

28 ich are notoriously poor substrates in other substitution reactions.

29 and the regioselectivities observed in model substitution reactions.

30 s rate-limiting in the nucleophilic aromatic substitution reactions.

31 ave on the stereoselectivity of nucleophilic substitution reactions.

32 tion enthalpies of the carbonyl to phosphine substitution reactions.

33 nd evaluated for regioselectivity in ammonia substitution reactions.

34 capable of catalyzing nucleophilic aromatic substitution reactions.

35 rate of the enzyme for nucleophilic aromatic substitution reactions.

36 classical SN1 and SN2 models of nucleophilic substitution reactions.

37 uch as reductions and vicarious nucleophilic substitution reactions.

38 zene reactivity gave access to oxidation and substitution reactions.

39 e of the different mechanisms of the allylic substitution reactions.

40 des popular starting materials in many photo-substitution reactions.

41 es in Ir-catalyzed, enantioselective allylic substitution reactions.

42 ibing the stereochemical outcome in suchlike substitution reactions.

43 e reactivity and selectivity of nucleophilic substitution reactions.

44 tramolecular ruthenium-catalysed propargylic substitution reactions(10).

45 ic base precursors (F, Cl, Br, and I) or via substitution reactions after the synthesis of the carboc

46 azoles and after intramolecular nucleophilic substitution reaction and electrooxidative disulfide bon

47 lted in an intramolecular radical [1,5]-ipso substitution reaction and migration of the pyrimidinyl r

48 red nucleophiles using nucleophilic aromatic substitution reactions and palladium-catalyzed reactions

49 iranes provide opportunities for bis-allylic substitution reactions and the generation of new vicinal

50 opure aminocyclopentenols, a Pd(0)-catalyzed substitution reaction, and a mild reduction of an alpha-

51 luence on catalysis of nucleophilic aromatic substitution reactions, and a H107S substitution account

52 Palladium-catalyzed allylic substitution reactions are among the most efficient meth

53 d by organic chemists, that radical aromatic substitution reactions are inherently unselective.

54 regioselective and enantioselective allylic substitution reactions are presented.

55 Most substitution reactions are thought to proceed through ra

56 Copper-mediated allylic substitution reactions are widely used in organic synthe

57 assemblies that is capable of catalyzing the substitution reaction at a secondary benzylic carbon cen

58 to prepare allyl terpene maleate monomer by substitution reaction at lower reaction temperatures.

59 which relies on a successive 2-fold SN'-type substitution reaction at methoxy-substituted propargylic

60 The nucleophilic substitution reaction at sulfur follows the addition-eli

61 ich undergoes an ipso electrophilic aromatic substitution reaction at the carboxylic acid-bound carbo

62 nctional theory calculations of model alkene-substitution reactions at a diimine-palladium(0) center

63 A series of gas-phase nucleophilic substitution reactions at sulfur of methanesulfinyl deri

64 The regioselective N-addition/substitution reaction between alpha-alkylidene pyrazolin

65 The first step involves a nucleophilic substitution reaction between aryl-BF3K salts (aryl = me

66 We discovered that the nucleophilic substitution reaction between carboxylate and alkoxyphos

67 he synthesis is a new vicarious nucleophilic substitution reaction between p-nitroanisole and a C-sil

68 ype I (PGGTase-I) catalyzes the nucleophilic substitution reaction between the C(20) geranylgeranyl d

69 he prodrug synthesis involves a nucleophilic substitution reaction between the parent tertiary amine

70 Ligand substitution reactions between five-coordinate oxorheniu

71 re synthesized through nucleophilic aromatic substitution reactions between ortho-difluoro benzene an

72 large changes in the emission though ligand substitution reactions between the solid complex and sol

73 Each enzyme catalyzes a nucleophilic substitution reaction, but IS and SS are uniquely able t

74 ge has much in common with familiar chemical substitution reactions, but differs in some respects: no

75 are not met during iridium catalyzed allylic substitution reactions by eta(3)-eta(1)-eta(3) interconv

76 be activated to stereospecific nucleophilic substitution reactions by precisely tailored bis-thioure

77 This study shows that the substitution reaction can be described as a concerted as

78 n an enantioselective intramolecular allylic substitution reaction catalyzed by a combination of pall

79 The reversible nucleophilic substitution reaction catalyzed by the vaccinia virus ty

80 t an unusual concerted nucleophilic aromatic substitution reaction (CSNAr) that is not limited to ele

81 n is provided, as are data from nucleophilic substitution reactions demonstrating that products are f

82 The kinetics of the substitution reaction depend on the size, shape, and bin

83 genase that involves a nucleophilic aromatic substitution reaction, either via an S(N)Ar mechanism or

84 Palladium (0)-catalyzed allylic substitution reactions employing triorganoindium reagent

85 ydroxyisocaproate dehydrogenase, and for the substitution reaction, employing cystathionine beta-lyas

86 The highly exoergic nucleophilic substitution reaction F(-) + CH3I shows reaction dynamic

87 ubjected to sequential nucleophilic aromatic substitution reactions, first at one or both of the more

88 The substitution reactions follow an addition-elimination pa

89 ures an intramolecular aromatic nucleophilic substitution reaction for formation of the diaryl ether

90 ted a room-temperature aromatic nucleophilic substitution reaction for formation of the remaining dia

91 ng system enlisting an aromatic nucleophilic substitution reaction for macrocyclization with biaryl e

92 f a versatile hemiacetal hydroxyl activation/substitution reaction for the formation of anomeric link

93 ough application to a classical nucleophilic substitution reaction for the study of solvent effects,

94 approach relied on two aromatic nucleophilic substitution reactions for formation of the 16-membered

95 port a significant expansion to the scope of substitution reactions for the dodecaborate ion, whereby

96 amic quantities for isomerization and ligand substitution reactions, gas-phase proton affinities, and

97 The vicarious nucleophilic substitution reaction has also been extended to six-memb

98 phospha-Mannich/intramolecular nucleophilic substitution reaction has been developed for the constru

99 phospha-Michael/intramolecular nucleophilic substitution reaction has been developed.

100 the palladium-catalyzed Tsuji-Trost allylic substitution reaction has been intensively studied, ther

101 this process and the regiochemistry of their substitution reactions has been studied.

102 e factors influencing the selectivity of the substitution reaction have been examined thoroughly.

103 de products that readily participate in acyl substitution reactions (hence, they are convertible).

104 plex catalytically promotes the nucleophilic substitution reaction (here after alpha-amidoalkylation

105 r of iodide > bromide > trifluoroacetate for substitution reactions; however, the basicities of bromi

106 We have discovered and studied a tele-substitution reaction in a biologically important hetero

107 iphenylcyclopropene undergoes a nucleophilic substitution reaction in alcohols and thiols to afford 3

108 from skipped enynes by a direct nucleophilic substitution reaction in HFIP at room temperature in ope

109 sumed to be a classical in-line nucleophilic-substitution reaction in which the 3'-hydroxyl of the pr

110 arenes occurs via an electrophilic aromatic substitution reaction in which the coordinated arene pro

111 portance of including electrophilic aromatic substitution reactions in atmospheric models.

112 )Et > monoester 3-CO(2)()Et) and may lead to substitution reactions in cellular systems.

113 emarkably lower reactivities in nucleophilic substitution reactions in protic solvents than in aproti

114 enable alcohols to be used as nucleofuges in substitution reactions in the future.

115 clophane scaffold and involving four coupled substitution reactions in the macrocyclization process.

116 picture contrasts that of traditional ligand-substitution reactions, in which the incoming ligand don

117 Redox potentials and substitution reactions indicate that the carbene is the

118 dence for a stepwise, S(N)1 mechanism in the substitution reaction induced by anion binding to the ca

119 ing as expected but rather undergoes ethynyl substitution reactions instead.

120 ical and to estimate the rate of the radical substitution reaction involved in the methyl transfer; a

121 structural motifs that undergo a reversible substitution reaction involving the concerted and spatia

122 The first instances of catalytic allylic substitution reactions involving a propargylic nucleophi

123 s employing catalytic electrophilic aromatic substitution reactions involving bromination.

124 In solution, nucleophilic vinylic substitution reactions involving electron-withdrawing gr

125 A series of nucleophilic substitution reactions involving simple species (chlorid

126 ite nucleophile involved in catalysis of the substitution reaction is located between Pro79 and Thr17

127 The palladium-catalysed allylic substitution reaction is one of the most important react

128 The substitution reaction is performed under ammonia flow by

129 ll mechanistic scenario for this propargylic substitution reaction is provided, including a catalyst

130 sion of gem-diesters to chiral esters by the substitution reaction is the equivalent of an asymmetric

131 the stereochemical outcome of a nucleophilic substitution reaction is unprecedented in the field of s

132 hat the diastereoselectivity of nucleophilic substitution reactions is attenuated at the limits of di

133 ies of 9H-carbazoles by photostimulated SRN1 substitution reactions is presented.

134 le played by the axial region in many ligand substitution reactions is therefore intimately connected

135 d by an intramolecular nucleophilic aromatic substitution reaction, is described.

136 fluorescence measurements indicate that the substitution reaction leading to compounds 4 can be util

137 ity of anilines in the aromatic nucleophilic substitution reaction leading to the formation of the TA

138 ,5- and then the 2,6-positions; nucleophilic substitution reactions occur first at the 8- followed by

139 omoted intramolecular electrophilic aromatic substitution reaction of 1-[2-(3,4-dimethoxyphenyl)ethyl

140 age of CS(2)/aromatization/nucleophilic acyl substitution reaction of 2-(4-oxo-2-thioxothiazolidin-5-

141 The intramolecular aromatic substitution reaction of 2-(diazoacetyl)pyrroles, cataly

142 ondensation-hydrolysis- nucleophilic vinylic substitution reaction of 2-chloropyridinium salts, isati

143 nucleophilic vinylic "addition-elimination" substitution reaction of 3 beta-acetoxy-17-chloro-16-for

144 The intramolecular nucleophilic substitution reaction of 3-oxo-2-(2'-pyridyl)-(2-halophe

145 nucleophilic vinylic "addition-elimination" substitution reaction of 3beta-acetoxy-17-chloro-16-form

146 The electrophilic substitution reaction of 4,7-dihydroindole with aryl-ald

147 The metal-catalyzed allylic substitution reaction of 5a,b and 6a was examined.

148 ated via base-induced vicarious nucleophilic substitution reaction of alkyl dichloroacetates with nit

149 nine may substitute for l-serine in the beta-substitution reaction of an engineered subunit of trypto

150 ivity based on a regioselective nucleophilic substitution reaction of Br4-NDI with arylamines, follow

151 in strong contrast to the previously studied substitution reaction of Cl(-) + CH3I at all but the low

152 emonstrated on the basis of the nucleophilic substitution reaction of CN(-) on (5F)LOH.

153 The nucleophilic substitution reaction of Cys-SeH on (NO2)L has been clea

154 al to study the dynamics of the nucleophilic substitution reaction of dichloroethane by a carboxylate

155 nthesis involved a new nucleophilic aromatic substitution reaction of methacrylamide anion.

156 The substitution reaction of phosphono allylic carbonate 10a

157 We have developed a copper-catalyzed substitution reaction of propargylic ammonium salts with

158 TFE) or hexafluoropropan-2-ol (HFP) mediated substitution reaction of the bay-region C10 acetoxy grou

159 cess is followed by FeBr3-mediated SN2'-type substitution reaction of the formed homoallenic bromohyd

160 monitoring the kinetics of the nucleophilic substitution reaction of the imidazole moiety by amines.

161 Aromatic nucleophilic substitution reaction of the nitro group of meso-nitropo

162 n the sequential intramolecular nucleophilic substitution reaction of the phosphonylation.

163 ion, followed by an intramolecular aromatic substitution reaction of the resultant cation (i.e., a d

164 The rate of the nucleophilic substitution reaction of tributylamine with methyl p-nit

165 The substitution reactions of 2 with 9-ethylguanine at vario

166 Nucleophilic substitution reactions of 2-deoxyglycosyl donors indicat

167 A systematic study of the N-substitution reactions of 3-substituted pyrazoles under

168 Nucleophilic substitution reactions of 4-substituted cyclohexanone ac

169 Other substitution reactions of [NiFe(3)S(4)](+) clusters and

170 inc complexes can either be formed by ligand substitution reactions of [Zn(2)(eta(5)-Cp*)(2)] or by r

171 Nucleophilic substitution reactions of acetals having benzyloxy group

172 Nucleophilic substitution reactions of alcohols are among the most fu

173 ay of methods for achieving nickel-catalyzed substitution reactions of alkyl electrophiles by organom

174 mplished by photochemically promoted allylic substitution reactions of allylic alcohols and ethers wi

175 Acetal substitution reactions of alpha-halogenated five- and si

176 Here, we use this approach to study the substitution reactions of arsenic(III) compounds with th

177 tacene derivatives via nucleophilic aromatic substitution reactions of bidentate nucleophiles and tet

178 Nucleophilic substitution reactions of C-4 sulfur-substituted tetrahy

179 S(N)2, and syn and anti S(N)2' nucleophilic substitution reactions of chloride anion with allyl chlo

180 n assessing the stereoselective nucleophilic substitution reactions of cyclic oxocarbenium ions at hi

181 t has been proposed to take place in related substitution reactions of cyclopentadienyl-metal complex

182 The photoinduced substitution reactions of halogenated alkanes (1-haloada

183 stituents were used in nucleophilic aromatic substitution reactions of halogens.

184 n dynamics strikingly different from that of substitution reactions of larger halogen anions.

185 substituted zirconacycles allowed for facile substitution reactions of MesC[triple bond]CPh or PrC[tr

186 The gas-phase substitution reactions of methyl chloride and 1,3-dimeth

187 Asymmetric lithiation-substitution reactions of N-Boc-pyrrolidine and N,N-diis

188 signed phosphine oxide promotes nucleophilic substitution reactions of primary and secondary alcohols

189 Nucleophilic substitution reactions of small rings incorporating sele

190 , is used to study the nucleophilic aromatic substitution reactions of SNAr and VNS (vicarious nucleo

191 Lewis acid-mediated nucleophilic substitution reactions of substituted tetrahydropyran ac

192 Nucleophilic aromatic substitution reactions of suitably activated (electron-d

193 addition to reductive coupling with alkenes, substitution reactions of tertiary radicals with allylic

194 Substitution reactions of the chemically and photochemic

195 yields and with high anomeric purities by S-substitution reactions of the sulfide anion or sulfur-ce

196 , was prepared and characterized, and olefin-substitution reactions of these complexes were found to

197 Partial substitution reactions of these W(6)S(8) complexes by ph

198 promoted intramolecular direct nucleophilic substitution reactions of unsaturated alcohols with hete

199 atalyzed regio- and enantioselective allylic substitution reactions of unstabilized silyl dienolates

200 eport Ir-catalyzed, enantioselective allylic substitution reactions of unstabilized silyl enolates de

201 as created from an unsaturated aldehyde by a substitution reaction on a derived allylic tosylate.

202 es have been shown to catalyze electrophilic substitution reactions on activated substrates.

203 for regio- and stereocontrolled bis-allylic substitution reactions on both electron-rich and electro

204 redict the outcome of electrophilic aromatic substitution reactions on different heterocyclic compoun

205 of "ylide" structures in Lewis acid induced substitution reactions on the boron vertices of carboran

206 l such conversions are based on axial-ligand substitution reactions on the molecular octahedron.

207 an effective LG for activating nucleophilic substitution reactions on tyrosine sites of proteins.

208 yl bromides and tosylates via a nucleophilic substitution reaction or by hydrothiolation of alkenes.

209 hotoinduced base-promoted homolytic aromatic substitution reaction (photo-BHAS) have remained elusive

210 The Tsuji-Trost allylic substitution reaction provides a useful and efficient ap

211 This newly developed substitution reaction provides an attractive alternative

212 nt, they were good catalysts for the allylic substitution reaction, providing branched allylic esters

213 to contribute about one-half of the overall substitution reaction rate at both low and high collisio

214 the alkenyl migration/electrophilic aromatic substitution reactions recently reported by Oshima and c

215 d regioselectivity in cyanidecarbon monoxide substitution reactions, relate to the enzyme active site

216 leophiles and alkyl electrophiles, many such substitution reactions remain out of reach.

217 io for the competing proton transfer and the substitution reactions results from the competition betw

218 he "element effect" in nucleophilic aromatic substitution reactions (S(N)Ar) is characterized by the

219 ne-pot tandem 1,4-addition-nucleophilic acyl substitution reaction sequence to afford 3-substituted 4

220 s the study of the competing elimination and substitution reactions simultaneously.

221 ylating agents defined by their nucleophilic substitution reactions (SN1 and SN2) are still unclear.

222 merize via a series of nucleophilic aromatic substitution reactions (SNAr), in which aromatic enolate

223 cal cascades, including unimolecular radical substitution reactions (SRN1-type chemistry), base-promo

224 We argue that substitution reactions take place after the two binary s

225 reoselective (>/=15:1) aromatic nucleophilic substitution reaction that benefits from substrate preor

226 DTT likely functions in a ligand substitution reaction that generates a [2Fe-2S]-DTT spec

227 ze the transition state of the in-line S(N)2 substitution reaction that is peroxidation.

228 not sufficiently activated for nucleophilic substitution reactions that are generally required for t

229 amples of catalytic enantioselective allylic substitution reactions that involve alkyne-based nucleop

230 play a dominant role in nucleophilic vinylic substitution reactions that proceed so readily in the co

231 alyze a variety of dissociative nucleophilic substitution reactions that proceed via oxocarbenium ion

232 port puts forward the first cases of allylic substitution reactions that result in the generation of

233 es as a "textbook example" of a nucleophilic substitution reaction, the selective mono-alkylation of

234 Through nucleophilic substitution reactions, the chlorides are useful precurs

235 have been employed in asymmetric lithiation-substitution reactions, the limited conformational flexi

236 In these copper-mediated allylic substitution reactions, the Z-isomer 4a displayed comple

237 )R) can be induced to undergo solvolysis and substitution reactions through an elimination-addition m

238 per configuration, and (d) an intramolecular substitution reaction to form the sensitive bridging lac

239 nt must be a stable cation precursor for the substitution reaction to proceed under these conditions.

240 Progress has been made for directed aromatic substitution reactions to achieve ortho and meta selecti

241 OCl(2)(bdt)](1-) (2), which undergoes ligand substitution reactions to form other monodithiolene comp

242 r further functionalization via nucleophilic substitution reactions to generate new fullerene derivat

243 The avoidance of electrophilic aromatic substitution reactions to make the isoquinoline allows d

244 lcohol and subsequently employs nucleophilic substitution reactions to prepare various derivatives.

245 ones 7-10 undergo stereoselective lithiation-substitution reactions to provide cis-18-27 and cis-31-3

246 (RBO) monomers in the gas phase by a radical substitution reaction under single-collision conditions

247 ives undergo the intramolecular nucleophilic substitution reaction upon treatment with a strong base,

248 The direct allylic substitution reaction using allylic alcohols in 1,1,1,3,

249 atropisomer-selective electrophilic aromatic substitution reaction using simple bromination reagents.

250 er, we report the effect of ionic liquids on substitution reactions using a variety of anionic nucleo

251 The molecularity of the dissociative substitution reaction varies, depending on the electroph

252 Classical substitution reactions via S(N)1 and S(N)2 pathways are

253 ene sulfide to the salen complex in a ligand substitution reaction was established by isolation of [R

254 In some cases the allylic substitution reaction was found to be accompanied by a k

255 The subsequent substitution reaction was found to proceed in moderate t

256 omponent Mannich-type electrophilic aromatic substitution reaction was previously developed to target

257 of indole to undergo electrophilic aromatic substitution reaction was studied in the past with methy

258 ular nitrile-activated nucleophilic aromatic substitution reaction was used for the key macrocyclizat

259 competent to be intermediates in the allylic substitution reactions was prepared and characterized by

260 In a DFT study of the substitution reaction, we identified a six-membered clos

261 A variety of nucleophilic aromatic substitution reactions were carried out mechanochemicall

262 Rate constants, kArO, for these substitution reactions were determined in 50% MeCN-50% w

263 ct, the activation parameters for the ligand substitution reactions were determined, and single-cryst

264 Finally, dynamic substitution reactions were employed toward the facile p

265 experiments confirmed that all nucleophilic substitution reactions were performed under kinetic cont

266 tively, the oxirane undergoes a nucleophilic substitution reaction where the conjugate base of Pro-1

267 with lithiated alcohols through nucleophilic substitution reactions where azide acts as an unconventi

268 substituted benzenes is capable of inducing substitution reactions where no reaction takes place the

269 lytic enantioselective nucleophilic aromatic substitution reaction which yields axially chiral biaryl

270 we perform an abiotic electrophilic aromatic substitution reaction, which is directed precisely throu

271 highly regioselective electrophilic aromatic substitution reaction, while metalation and alkylation p

272 T7/9 is a typical in-line S(N)2 nucleophilic substitution reaction with a transition state of 70% dis

273 derivatives underwent a direct nucleophilic substitution reaction with alkyl Grignard reagents in th

274 s, as its acetate 4, discovered to undergo a substitution reaction with cysteine derivatives.

275 >99%) after recrystallization and (b) S(N)2 substitution reaction with methylamine to provide diamin

276 onate wafers using an electrophilic aromatic substitution reaction with nitric acid to insert aromati

277 of the diol followed by double nucleophilic substitution reaction with primary amines led to the syn

278 The first example of Ir-catalyzed asymmetric substitution reaction with vinyl trifluoroborates is des

279 propose a general mechanism for the allylic substitution reactions with 1 which involves dissociatio

280 also describe high yielding and C6-selective substitution reactions with 6-bromonucleosides using alc

281 Surprisingly facile direct substitution reactions with acetyl-protected 6-bromopuri

282 with electron-deficient alkenes and radical substitution reactions with allylic and vinylic bromides

283 en atom undergo smooth nucleophilic aromatic substitution reactions with anionic sulfur nucleophiles

284 l equivalent then undergoes nickel-catalyzed substitution reactions with aryl halides and triflates a

285 Substitution reactions with carbon, nitrogen, oxygen and

286 that are crosslinked in situ by nucleophilic substitution reactions with carboxylates.

287 ope effects operating through four bonds for substitution reactions with dimethylallyl derivatives be

288 roducts undergo cross-coupling reactions and substitution reactions with ipso selectivity to generate

289 iments, undergoes gas-phase enantioselective substitution reactions with other amino acids.

290 idine products undergo nucleophilic aromatic substitution reactions with oxygen and carbon nucleophil

291 8-arylBODIPY derivatives suitable for S(N)Ar substitution reactions with phenols exclusively at posit

292 from the parent borane dipp-Imd-BH(3) by (1) substitution reactions with R-X (X = halide or sulfonate

293 was demonstrated via highly enantiospecific substitution reactions with suitably reactive nucleophil

294 ewis acids to mediate electrophilic aromatic substitution reactions with super-stoichiometric equival

295 Nucleophilic aromatic substitution reactions with the hydroxide and hydrosulfi

296 o- and enantioselective Ir-catalyzed allylic substitution reactions with the proper choice of enolate

297 tom, were prepared and subjected to SN1-type substitution reactions with various silyl nucleophiles e

298 sis, including the following: transamination substitution reactions with virtually any primary amine,

299 The nucleotide product of this substitution reaction would be N2-hydroxyguanosine 5'-mo

300 n prototypical identity nucleophilic vinylic substitution reactions, X(-) + ViX --> XVi + X(-) (Vi =