ライフサイエンスコーパス: substrain

1 tated Nnt(C57BL/6J) allele from the C57BL/6J substrain.

2 ceptible RED strain and the resistant MOYO-R substrain.

3 ia major infection depending on the parasite substrain.

4 y stimuli compared with the related C57BL/6N substrain.

5 te a highly conserved branch of the HTLV-IIB substrain.

6 em cell line derived from a related C57BL/6N substrain.

7 C57BL/6N substrains, but not in the C57BL/6J substrain.

8 une arthritis, unlike the wild-type B10.Q/Ai substrain.

9 red in its entirety within a single congenic substrain.

10 endent of frequency of Th17 or Th1 in either substrain.

11 esponses similar to those of other C3H mouse substrains.

12 Mp-lpr/lpr strains to generate C1q-deficient substrains.

13 gence of behavioral performance in these 129 substrains.

14 was present on epithelial structures in both substrains.

15 pic and phenotypic differences between these substrains.

16 infiltrating lacrimal gland lesions in both substrains.

17 etabolic disease is similar in the 6J and 6N substrains.

18 c orchitis (EAO) exists among various BALB/c substrains.

19 an disease, makes extensive use of 129 mouse substrains.

20 thand C57BL/6 is often used to describe both substrains.

21 ed yellow fever vaccines produced from three substrains.

22 -deficient 6J mice and NNT-competent C57BL/6 substrains.

23 susceptible wild-type and initial resistant substrains.

24 y divergent, yet genetically similar, rodent substrains.

25 ignificantly, and similarly with age in both substrains.

26 d mice and was not different between the two substrains.

27 NOD/ShiLtJ (CHORI-29), two commonly used NOD substrains.

28 only in BALB/cJ mice and not in other BALB/c substrains.

29 sceptible to infection as other C3H (H-2(k)) substrains.

30 J mice to those of TLR4-sufficient C3H mouse substrains.

31 d MRL/lpr (mean difference 33.6%, P < 0.001) substrains.

32 of all groups tested, suggesting that linked substrain 129 alleles, not the absence of D2 receptors p

33 an induced severe arthritis in the C3H/HeJCr substrain (95-100% incidence), whereas the original pare

34 Draxin expression in BTBR/R also makes this substrain a more precise model to investigate the core e

35 sal agenesis and behavior in the 129/SvEvTac substrain and compared their behavior to that of C57BL/6

36 nalyses, we ranked polymorphisms in C57Bl/6N substrain and selected genes Crb1, Cyfip2, Adamts12, Plk

37 wering effect demonstrated by the S.R(ET3x5) substrain and the BP lowering effect retained by the S.R

38 or characterizing sequence variants in these substrains and demonstrate their use in quantitative ana

39 lead to extensive genetic variability among substrains and embryonic stem cells derived from them.

40 This review will describe these two substrains and highlight the importance of separate cons

41 inge eating in closely related C57BL/6 mouse substrains and in an F2 cross to identify quantitative t

42 strate their use in quantitative analysis of substrains and sequence variations in mixed virus cultur

43 Studies in rodent substrains and subpopulations are providing new insights

44 rt weight comparisons between these congenic substrains and their S control localized the BP QTL to a

45 etic relationship between four C57BL-derived substrains and used the panel to map two N-ethyl-N-nitro

46 The dacryoadenitis in both substrains appears to be Th2 in nature, with little IFN-

47 These selected substrains are an ideal resource for forward and reverse

48 died primarily in C57BL/6 mice, however, 129 substrains are commonly used in gene-targeting experimen

49 overage sequencing data confirm that the two substrains are nearly coisogenic.

50 Furthermore, considering that C57BL/6 substrains are relatively resistant to kidney damage, th

51 e distinguishing features of the SAMP1/YitFc substrain at the University of Virginia, compared with t

52 in IL-12-dependent IFN-gamma responses in a substrain (B10.Q-H2-(q)/SgJ) of B10.Q mice that manifest

53 entials and PPI in these two closely related substrains based on the hypothesis that any observed end

54 d 129, we document that outcrossing of these substrains, both deliberate and accidental, has lead to

55 mutation in homozygous form in all C57BL/6N substrains, but not in the C57BL/6J substrain.

56 during the critical period, whereas another substrain, C57BL/6J (6J), exhibits both plasticity proce

57 dominant screening for obesity using C57BL/6 substrains, C57BL/6J and C57BL/6N, with the routine use

58 In this study, two common substrains, C57BL/6J and C57BL/6NHsd, exhibited differen

59 Furthermore, a DBA/2 substrain, called DBA/2J-Gpnmb+/SjJ, contains the wildty

60 ed ablation of this gene in the NOD/ShiLtDvs substrain completely inhibited diabetes development.

61 ell response to MCMV infection in novel BALB substrains congenic for different MHC (or H-2 in mice) h

62 ed glaucoma, using as a control the congenic substrain DBA/2J Gpnmb(+/SjJ) (D2G), which is not affect

63 cle bacilli tested and was deleted only from substrains derived from the original BCG Pasteur strain

64 ility to Candida vaginitis in derived murine substrains differing in sensitivity to estrogen (CD-1 an

65 and IL-4Ralpha-/- mice infected with either substrain displayed reduced Th2 responses.

66 macrophages from this Gpnmb-preserved DBA/2 substrain exhibited recovered lysosome function.

67 We found that DBA/2Hsd substrain exhibited reduced inhibition of evoked potenti

68 C3H/He substrains exhibited a modest incidence (average of 19 S

69 The SAMP1/YitFc substrain exhibits unique characteristics when compared

70 hus, the authors decided to test several 129 substrains for their behavioral characteristics.

71 hil migration, induced by the other L. major substrain, Friedlin, was unaffected, and the initial par

72 Sisa1, a congenic substrain from the SHR.WKY-Sa animals carrying an introg

73 ial protein was found in the M. tuberculosis substrains H37Rv, H37Ra, Erdman, and "C" strain, as well

74 Five of the six congenic substrains had significantly lower BP compared to the pa

75 The inbred 129 substrains have been characterized as poor learners that

76 In 2013, a descendent substrain (hereafter, the "2013 strain") became the domi

77 ross onto highly fibrosis-susceptible BALB/c substrain, identified in inbred mouse strain screening.

78 studies suggest that regardless of parasite substrain, IL-10 is as important as IL-4/IL-13 in promot

79 ferences between C3H/HeJ and other C3H mouse substrains in response to M. tuberculosis infection.

80 es associated with development of CP in both substrains, including RIKEN cDNA 1810009J06 gene (trypsi

81 t for IL-4R alpha-chain (IL-4R alpha), while substrain IR173 was highly controlled.

82 mmonly used CD45.1(+) congenic C57BL/6 mouse substrain is characterized by selective deficiency in Vg

83 tic diversity among WKY progenitors, the WMI substrain is significantly more vulnerable to stress rel

84 function, these findings suggest that the 6N substrain is the more logical and representative genetic

85 ypically contain at least two distinct viral substrains, JL1 and JL2, which have been characterized b

86 priate back-crossing to other C57BL/6J mouse substrain lines without this deletion.

87 Because many of the C3H substrains lost arthritis susceptibility or acquired res

88 In previous studies the L. major substrain LV39 caused progressive, nonhealing lesions in

89 han that previously reported in the C57BL/6J substrain maintained by Envigo.

90 Whole-genome sequences of substrains make RCCs possible by supporting the developm

91 d website dedicated to Escherichia coli K-12 substrain MG1655 that is revised daily using information

92 sistance but not in virus-susceptible DBA/2J substrain mice.

93 The differences between the substrains might reflect genetic drift.

94 Several strains and substrains mirrored the high and low responses of B6 and

95 genetic heterogeneity among inbred C3H mouse substrains modifies resistance to infection.

96 MRL/MpJ mice of substrains MRL/MpJ-fas(+)/fas(+) (MRL/+) and MRL/MpJ-fas

97 th this idea, we found that an often-studied substrain of C57BL/6 mice, C57BL/6JOlaHsd (6JOla), lacks

98 pic MuLVs identified in mice infected with a substrain of Friend MuLV (F-MuLV57) are reactive with Hy

99 The moderate seizure severity substrain of genetically epilepsy-prone rats (GEPR-3s) e

100 ing generalized AGS in the moderate severity substrain of genetically epilepsy-prone rats (GEPR-3s).

101 seizure (AGS) ('AGS kindling') in the severe substrain of genetically epilepsy-prone rats (GEPR-9s) r

102 When the substrain of L. major, LV39, was infected, lack of galec

103 Here we describe an FVB substrain of mice in which this repertoire was uniquely

104 titative morphology in eyes of the DBA/2NNia substrain of mouse (DBA) with inherited angle-closure gl

105 F-11A cells are a substrain of murine neuroblastoma F-11 cells that contai

106 sed echocardiographic selection to develop a substrain of myosin light chain (MLC)-Ras (RAS) transgen

107 ons of the GEPR-3 (moderate seizure severity substrain of the GEPR).

108 Interestingly, two substrains of 129 mice were resistant to high-dose Y. pe

109 Multiple substrains of AdV E4 are in circulation but all appeared

110 Rather, the changes suggest that substrains of an established infecting strain are shuffl

111 electroencephalography (EEG) in C3H/He mice, substrains of C3H mice were evaluated by EEG and sensiti

112 Finally, embryos from two substrains of C57BL mice that differ in susceptibility t

113 Two substrains of GEPRs exist, GEPR-9s, exhibiting tonic AGS

114 We report that females of some substrains of inbred mouse strain 129 are resistant to s

115 The M. bovis type strain, five substrains of M. bovis BCG (Copenhagen, Glaxo, Japanese,

116 deletion mutations in the chromosomes of two substrains of M. bovis BCG and M. tuberculosis H37Rv.

117 C57BL/6J and 129 substrains of mice are known to differ in their basal le

118 as(lpr)/fas(lpr) (MRL/lpr) mice are congenic substrains of mice that have spontaneously developing la

119 is considered an inherent property of LICs, substrains of NOD/SCID mice that possess additional dele

120 We previously reported that multiple substrains of the 129 mouse background are resistant to

121 atients with recurrent infections, different substrains of the established clone dominate in an appar

122 e show that multiple distinct wild-type (WT) substrains of the highly polyploid cyanobacterium Synech

123 n in DBA/2J mice, using genetically modified substrains of this inbred line.

124 be necessary to determine whether particular substrains of viruses confer an elevated risk of asthma

125 ll nonarthritic animals, regardless of their substrain origin.

126 in, whereas, in its absence, the susceptible substrain outgrew its resistant counterpart.

127 nds but different CP phenotypes of these two substrains presents a unique opportunity to discover gen

128 Comparison of seven congenic substrains refined QTL1 to a 1.17 Mb segment flanked by

129 y or resistance in the C3H/HeJCr and C3H/HeJ substrains, respectively, significant differences were f

130 n because few persist between separate mouse substrains, rodents, or primates.

131 Two nonoverlapping substrains, S.R(ET3x1) and S.R(ET3x6), had significantly

132 The WKY More Immobile (WMI) substrain shows high immobility/despair-like behavior in

133 icroevolution within a clonal population and substrain shuffling in recurrent infections.

134 ndom fashion, a process that we refer to as "substrain shuffling".

135 reation of 2 new mutually exclusive congenic substrains (Sisa1a and Sisa1b) and interrogation of cand

136 Only 1 of the substrains (Sisa1a) continued to demonstrate a BP differ

137 Of eight substrains studied for EAE and 13 for EAO, BALB/cJ mice

138 Mice of 10 C3H substrains (subcolonies) were immunized with cartilage p

139 plasticity was identical in the 6JOla and 6J substrains, suggesting that adult plasticity occurs by a

140 ls resulted in the selective enrichment of a substrain, termed TB40/EE, which infected epithelial cel

141 C3H/HeJBir is a mouse substrain that is highly susceptible to colitis.

142 C3H/HeJBir mice are a new substrain that spontaneously develop colitis early in li

143 te that there is genetic variability in 129S substrains that affects their ability to mount antiviral

144 ility to L. major and even more so for those substrains that are relatively resistant to IFN-gamma me

145 ntially regulated expression between the two substrains that might be candidates in CP progression in

146 mammals and present a framework to use mouse substrains to identify previously unknown genes and alle

147 P lowering effect retained by the S.R(ET3x2) substrain together define the RNO3 BP QTL-containing reg

148 ce of the rd8 mutation in the C57BL/6N mouse substrain used widely to produce transgenic and knockout

149 ative prevalence of the original UK and 2013 substrains, using multiple disease and carriage isolates

150 fficacy, but evidence is limited to the 17DD substrain vaccine.

151 This clearer understanding of 129 substrain variability allows consideration of its negati

152 A second iteration of congenic substrains was used to localize the QTL further to a 2.4

153 DNA segment found to be deleted from all BCG substrains, was conserved in all virulent laboratory and

154 gle region (RD1), which is absent in all BCG substrains, was deleted from virulent M. bovis and Mycob

155 oss of visual acuity between these two DBA/2 substrains, we also conclude that DBA/2NHsd mice are a s

156 t background, further iterations of congenic substrains were constructed and characterized to fine-ma

157 In the current work congenic substrains were constructed from the progenitor congenic

158 the congenic region of RNO3 and six congenic substrains were developed that carry shorter segments of

159 Seven 129 substrains were put through a battery of tasks to determ

160 hibitor swainsonine selected for a resistant substrain, whereas, in its absence, the susceptible subs

161 lion nucleotides from 1000 related bacterial substrains, whereas the method of Metsky et al. shows cl

162 pr) and MRL/Mp-+/+ (MRL/+) mice are congenic substrains, which differ only by a single autosomal rece

163 in the genetic background have risen between substrains, which have major implications in the phenoty

164 with normal CSF-cN distribution and C57Bl/6N substrain with majority of CSF-cNs in ectopic position.

165 advantage of close consanguinity of C57Bl/6J substrain with normal CSF-cN distribution and C57Bl/6N s

166 This fragment was present in the DBA/2N substrain with Rmcf-mediated resistance but not in virus

167 read demand has led to generation of several substrains with subtly different phenotypes.

168 nomic sequence variants distinguishing these substrains with the long term goal of uncovering functio

169 is demyelinating disease exists among BALB/c substrains, with BALB/cAnNCr mice being susceptible whil

170 s and reduced startle relative to the DBA/2J substrain without alterations in auditory sensitivity, a

171 he forced swim test (FST), while the control substrain, WKY Less Immobile (WLI), shows no depressive

172 l cytochrome c-551 from Pseudomonas stutzeri substrain ZoBell has been mutated to convert the invaria

173 e cluster nirFDLGH from Pseudomonas stutzeri substrain ZoBell on a high copy plasmid.

174 for cytochrome c-551 in Pseudomonas stutzeri substrain ZoBell, was engineered to mutate Met61, the si