ライフサイエンスコーパス: substrate

1 " state until the specific binding of a true substrate.

2 hile the filter paper is pressed against the substrate.

3 lated reaction and enables the uncaging of a substrate.

4 ward the N-glycan compared to another glycan substrate.

5 prepared on a commercial flat-sheet ceramic substrate.

6 ted by autoubiquitination and a soluble ERAD substrate.

7 ificity of intrinsic Xase for its biological substrate.

8 ity, and is not an efflux transporter (P-gp) substrate.

9 tallurgical bonding between the clad and the substrate.

10 zyme and then transferred in one step to the substrate.

11 r and a low index waveguide layer on a glass substrate.

12 2 in nuclear PQC degradation varies with the substrate.

13 phosphorylation of CHK1, the downstream ATR substrate.

14 as high frequency, low-loss waveguides on a substrate.

15 eliably created and freely moved on a sample substrate.

16 nd that 5-OHBza-R is the most favored MtBzaC substrate.

17 promise upon limitation of the corresponding substrate.

18 placement of UPF1 already bound to potential substrates.

19 o interact with DCX, but not with other cdk5 substrates.

20 spect to cellular levels of their nucleotide substrates.

21 hich requires disordered ends in its protein substrates.

22 accessed chemoenzymatically using synthetic substrates.

23 om the N or C-termini of peptide and protein substrates.

24 ndensation of water vapor on low-temperature substrates.

25 fice-copy papers work as flexible supporting substrates.

26 20% are achieved, both on rigid and flexible substrates.

27 e shift of conjugated bis-aryl cycloalkenone substrates.

28 material softening dominates on hydrophobic substrates.

29 -uptake flux rather than the identity of the substrates.

30 mediate the degradation of distinct cellular substrates.

31 with active phosphatases for the binding of substrates.

32 if specificity and expands the repertoire of substrates.

33 ns and phosphorylate an extensive network of substrates.

34 ecognize and accommodate several diverse DNA substrates.

35 tures distinguishing these unique endogenous substrates.

36 or the efficient synthesis of heteroaromatic substrates.

37 Motifs (SIMs) required to bind SUMO modified substrates.

38 rly reactive towards sterically bulky alkene substrates.

39 tions suggesting distinct effects of the two substrates.

40 generally, two-dimensional fluids on curved substrates.

41 alkaline phosphatase from hydrolysing these substrates.

42 or identification of myocardial pathological substrates.

43 tial H3K4 demethylase activity on nucleosome substrates.

44 sing effects on cellular handling of various substrates.

45 ore selective processes for less constrained substrates.

46 es the CoREST repressor to act on nucleosome substrates.

47 a large linker domain blocks activation and substrate access.

48 sits atop the enzymatic pocket and occludes substrate accessibility.

49 mechanistic challenge to control the mode of substrate activation as well as origin of enantio- and d

50 catalysts have enabled novel multifunctional substrate activation modes and unprecedented selectivity

51 -RING ubiquitin ligase (CRL), containing the substrate adaptor ZSWIM8, that mediates TDMD.

52 of BPM (BTB/POZ-MATH) proteins, which act as substrate adaptors of CUL3-based E3 ubiquitin ligases.

53 We also demonstrate that substrate adhesion and integrin localization are enhance

54 rface interaction, without damaging the SERS substrate, allowing for efficient sensor reuse.

55 , invoking direct nucleophilic attack by the substrate alpha-amino group on the sn-2 ester to form a

56 ransmembrane domain (TMD) housing the Zn(2+) substrate; an interfacial site between TMD and C-termina

57 ble covalent interactions between an organic substrate and a chiral mediator, we have developed a tra

58 king effect and the steric hindrance between substrate and catalyst.

59 se 3 (ANT3) as a previously unknown mortalin substrate and cell survival/death effector.

60 Depending on the substrate and conditions, the Banert cascade can proceed

61 nanoribbons can readily be removed from its substrate and dispersed in solution.

62 omain mobility, and associated the histidine substrate and docking domains with the kinase core, thus

63 tself and other surfaces, as a soft, elastic substrate and encapsulation coating for wireless electro

64 us to determine how heparanase recognizes HS substrate and selects a favorable cleavage site.

65 s ability to O-fucosylate itself and a model substrate and to specifically hydrolyze GDP-Fuc.

66 However, nonhistone substrates and additional catalytic activities of SIRT6,

67 of human VKOR and pufferfish VKOR-like, with substrates and antagonists in different redox states.

68 earning-based predictor of protease-specific substrates and cleavage sites.

69 gnins, including the identification of novel substrates and enzyme activities towards the synthesis o

70 ells exhibited elevated levels of NUDT3 mRNA substrates and increased P-body abundance.

71 r the growth of A. baumannii on host-derived substrates and is involved in desiccation tolerance, imp

72 The plant supplies carbon substrates and other nutrients to the bacteria in exchan

73 s, and accumulation of plasmanylethanolamine substrates and resulted in an inability of these cells t

74 me fascinating issues about representational substrates and structures in the predictive brain.

75 e observe transient interactions between DNA substrates and the Rad50 coiled coils.

76 Sulfamethazine (NAT2-selective substrate) and NAT2 protein expression differed signific

77 obust, to enable rapid ubiquitylation of the substrate, and fragile, to enable the subsequent functio

78 ivergence between enzymes based on organism, substrate, and mechanism.

79 Mutations in nuclear export stabilized substrates, and caused accumulation in the nucleus.

80 capillary adhesion dominates on hydrophilic substrates, and material softening dominates on hydropho

81 ltimarker antibody cocktails, nanostructured substrates, and microfluidic chaotic mixers.

82 y recognizes 3' intrinsic terminators of RNA substrates, and that the discrimination between RNA liga

83 the intermolecular interactions between the substrates, and the triplet state reaction paths.

84 zation in different forms, both with/without substrates, apparently by promoting oligomerization invo

85 e interfacial bonds with the heteroepitaxial substrate are broken to create a freestanding film.

86 (group D), which use reduced flavin as a co-substrate, are less amenable to spectroscopic investigat

87 UGT, enables functionality testing with many substrates as well as other applications for further ana

88 zes that the use of chalcophilic elements as substrates as well as the Mo/W ligand in DMSORs has inde

89 ndent kinases (CDKs) phosphorylate different substrates at different stages, thus enforcing a tempora

90 and appeared to depend on a balance between substrate availability and biotic interactions.

91 within bacteria in environments where growth substrate availability is difficult to quantify can have

92 ntify recognition elements of transpeptidase substrates, (b) reveal a novel mechanism of stereochemic

93 e structures show how the donor and acceptor substrates bind in the active site and how ethambutol in

94 ansition of the ankyrin repeat motifs in the substrate binding domain of cpSRP43 drives its activatio

95 h and without evidence of donor and acceptor substrate binding obtained using a crystal engineering a

96 high selectivity when targeting the peptide substrate binding site of NTMT1/2.

97 ground mutants display significantly reduced substrate binding, catalytic efficiency, and inhibitor b

98 mutagenesis to identify residues involved in substrate binding.

99 auses a change in the DeltaH associated with substrate binding.

100 de bonds and reductively eliminate H(2) upon substrate binding.

101 ht into dynamic loop movements that occur on substrate binding.

102 esult in a partially collapsed inward-facing substrate-binding cavity.

103 (2020) discover that the C-terminal substrate-binding domain of FBXL5 contains a redox-sensi

104 e Spf1 revealed a large, membrane-accessible substrate-binding pocket that alternately faced the ER l

105 ed that, because DapF (Ct) utilizes a shared substrate-binding site for both racemase and epimerase a

106 tive site is almost identical to that of the substrate-bound structure and satisfies all hydrogen-bon

107 o suggests that ATMs of lean mice serve as a substrate buffer or reservoir to modulate lipid, catecho

108 t glycerol uptake defers to other glycolytic substrates but not to gluconeogenic ones.

109 y heterogeneous peri-infarct zone is a known substrate, but the functional role of the myocytes is le

110 sights for the potential prediction of novel substrates by combining additional approaches.

111 Impairing astrocytic delivery of energy substrates by reducing astrocyte gap junction coupling w

112 ergent access to different products from one substrate can be facilitated, isomeric olefin mixtures c

113 d memory formation by strategic selection of substrate cells, and gene-engineering with synthetic co-

114 interruption of the cofactor channel and the substrate channel via the conformational changes of its

115 agnetostriction, are severely reduced by the substrate clamping effect.

116 tion procedure which involves (1) a modified substrate cleaning procedure and (2) prebake at 700 degr

117 hput bioanalysis of metformin, a small polar substrate commonly used in high-throughput in vitro tran

118 In the present study, we employed a substrate competition strategy to demonstrate DapF (Ct)

119 to a plausible resting state of the catalyst-substrate complex predisposed for asymmetric chlorolacto

120 We analyzed substrate composition and fate of 216 P. unifilis nests

121 ssay, including the importance of enzyme and substrate concentrations, covariation of magnesium and n

122 suppressing aggregation, but how they affect substrate conformations remains poorly understood.

123 allows exquisite control over the patterned substrate/crystal lattice mismatch, something not yet re

124 (TGA), diagnoses with lowest fetal cerebral substrate delivery; "CHD-other," with other CHD diagnose

125 re we report a lithium-ion solid electrolyte substrate, demonstrating its application in high-perform

126 tic domain of human MANEA and complexes with substrate-derived inhibitors, which provide insight into

127 a atomistic modeling of the CdSe surface and substrates, determination of the thermodynamic energies

128 sent a structure of this domain bound to the substrate diC8-PI(3,4,5)P(3), providing the first image

129 he intervening air layer between droplet and substrate during impact, a balance of air compression an

130 r has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol.

131 theory calculations were carried out on the substrate-Fe(III) complexes, which shed light on diaster

132 ron transport system serve as a barometer of substrate flux relative to demand, continuously adjustin

133 nderpotential deposition of copper on a gold substrate followed by in situ redox replace reaction in

134 piral's seam, which we propose positions the substrate for entry into the pore.

135 ippocampal formation is a crucial functional substrate for episodic memory and spatial representation

136 evidence that malonyl-CoA, the rate-limiting substrate for fatty acid synthesis (FAS), is produced in

137 Atelocollagen provides a suitable substrate for MSC attachment and enhancing chondrogenic

138 e possibility of doxycycline uptake from the substrate for mushroom cultivation by the white button m

139 tified neuronal Prkag3 mRNA as a mechanistic substrate for NMD that contributes to the UPF2-mediated

140 so affect DNA repair capacity as NAD(+) is a substrate for PARP-enzymes (mono/poly-ADP-ribosylation)

141 rocessing (based on degradation of DQ-OVA, a substrate for proteases which upon hydrolysis is fluores

142 when expressed with zDHHC20, and MBLAC2 is a substrate for purified zDHHC20 in vitro.

143 The heterogeneous peri-infarct zone forms a substrate for re-entry while arrhythmia initiation is of

144 ced the term "engram" to describe the neural substrate for storing memories.

145 t nucleotide 991, creating an additional DNA substrate for the unessential but highly conserved A* pr

146 e simple to make and can be useful electrode substrates for (single molecule) spectroelectrochemistry

147 te a variety of internal aromatic alkynes as substrates for cyclopropenation with unprecedented effic

148 he potential to reveal the underlying neural substrates for developing a cognitively flexible brain d

149 ifically azetidinium triflates, are suitable substrates for enantioselective ring opening with CsF an

150 hondrial respiration to control the usage of substrates for production of heat versus ATP.

151 were previously identified that may serve as substrates for RMCE reactions for future potential gene

152 neural activity, we reveal potential neural substrates for the pathophysiology of neuropsychiatric d

153 a continuum model of biofilm growth against substrate friction.

154 similar affinities for S7P and the canonical substrate fructose 6-phosphate (F6P).

155 olubility and bioavailability of the NanoLuc substrate furimazine.

156 oss-correction in vivo, the role of the GALC substrate galactosylceramide, and the origin of psychosi

157 layers of VSe(2) grown on graphite or MoS(2) substrate has opened new opportunities to explore these

158 We also review how access to these substrates has now enabled biochemical studies that deep

159 Recently, it was reported that AspH substrates have a non-canonical EGFD disulfide pattern.

160 Despite their importance, ADAR RNA substrates have not been mapped extensively in vivo.

161 nspeptidation, and (d) demonstrate that both substrates have to be bound before transpeptidation occu

162 e approached with caution in the presence of substrate heterogeneity or variable sample thickness.

163 Here, we report a new substrate, hydrofurimazine, whose enhanced aqueous solub

164 idylinositol 4,5-bisphosphate (PIP(2) ), the substrate hydrolysed by PLC, and intracellular Ca(2+) .

165 The 71 UGGT substrates identified were mainly large multidomain and

166 nsures stabilization of its putative protein substrate IFN-gamma receptor 1 (IFNGR1) at the protein l

167 irst image of a 5-phosphatase with a trapped substrate in its active site.

168 3-Hydroxyhispidin acts as a luciferin substrate in luminescent fungi.

169 on and interact with two-residue segments of substrate in the axial channel, as observed for other AA

170 While the phenolic substrate in this study is fixed at the NP@MOF interface

171 sferases by binding to the same site as both substrates in EmbB and EmbC.

172 used to show that Vif degrades these PPP2R5 substrates in roughly the same time frame as APOBEC3 deg

173 In DdPhyA, two mobile loops that enclose substrates in the PHDs are conserved, but the C-terminal

174 T) sensors on seven different types of paper substrates including nitrocellulose, nylon, poly(vinylid

175 ydrolyze cyclic phosphate bonds on different substrates, including cyclic nucleotides.

176 been shown to each secrete a distinct set of substrates, including PE and PPE families of proteins, n

177 is extensively examined through a variety of substrates, including synthesis and late-stage functiona

178 We apply this strategy to various substrates-including silicon, ceramic, metal and transpa

179 Likewise, stiff substrates induce microglial bipolarization and diminish

180 ined growth of fibroblasts on micropatterned substrates induces stem-cell-like spheroids.

181 odopseudomonas palustris, the type of carbon substrate influences the relative rates of diazotrophic

182 nithine decarboxylase reveals how the larger substrate is accommodated and how active site residues h

183 - to the inward-facing state, when the bound substrate is translocated from the extracellular to the

184 istic understanding of how Msp1 extracts its substrates is still lacking.

185 In films deposited on orthorhombic substrates it tends to align with the shorter axis; howe

186 We identify binding sites for substrate K(+) and Cl(-) ions, demonstrate the importanc

187 in high-permittivity gallium arsenide (GaAs) substrate layer.

188 The substrate Leu-FC empowered sensor displayed broad dynami

189 e MurJ, we find that addition of the natural substrate lipid-II results in the formation of a 1:1 pro

190 ng protein unfolding, increasing further the substrate load on proteasomes, and, thus, putting furthe

191 the RVOT, congruent with the arrhythmogenic substrate location detected by epicardial potential dura

192 rmal contact to adhesive contact for various substrate material properties, surface energy and roughn

193 d to MlaFEDB, suggesting that multiple lipid substrates may be transported each cycle.

194 at chain debranching promotes degradation of substrates modified with branched chains under multi-tur

195 First, the shape of the substrate nanocrystal must guide the crystallographic or

196 as well as its catalytic activity toward its substrate Notch, a critical regulator of B cell and T ce

197 In fact, during the reduction of substrates, NQO2 generates fairly unstable intermediates

198 the deacetylation of cortactin, a nonhistone substrate of HDAC8, and increased expression of three fi

199 intervention strategies, the neurobiological substrates of ELA-attributable differences remain unknow

200 ation, and that the critical neuroanatomical substrates of g and working memory include the arcuate f

201 rther expand our understanding of the neural substrates of memory.

202 rying in both charge and composition, as the substrates of PfCRT in vitro and in situ, and show that

203 e absence of catalytic activity, PTPRU binds substrates of related phosphatases strongly suggesting t

204 rotein production, but previously identified substrates of the redirected ligase do not explain these

205 d that some of these compounds were in vitro substrates of the transporter and validated the differen

206 he host gastrointestinal tract and which are substrates of the V. cholerae RND efflux systems.

207 hich catalyzes the myristoylation of protein substrates, often to mediate membrane targeting.

208 Here, we evaluated the effect of substrate on nest removal by humans in the eastern Brazi

209 tion, (c) assess the impact of peptidoglycan substrates on beta-lactam targeting of transpeptidation,

210 iquitin chains are built unit by unit on the substrate, or a preassembly model, in which polyubiquiti

211 Features at each end of the substrate overcome this barrier and promote release by s

212 Substrate oxidation was unchanged, and safety monitoring

213 ein to obviate possible chaperone effects on substrate physical state or transport.

214 ymes are assembled into metabolons and which substrate pools are used by each is still not well under

215 surface smoothness; moreover, an additional substrate preparation procedure which involves (1) a mod

216 pairing wildtype PKS modules with non-native substrates primarily resulted in poor conversions to ant

217 posed to disrupt the dimer, slow the rate of substrate processing by ~35 %.

218 Analysis of the substrate profile of AldC suggests that this enzyme func

219 show that acidic residues N-terminal to the substrate pTyr in EGFR and HER2 mediate specific binding

220 gregation, and conformation while modulating substrate reactivity and selectivity.

221 les the nicked substrate with the VirD4-like substrate receptor.

222 lizing F-box only protein 44 (FBXO44) as the substrate recognition component.

223 n energy, can help characterize a protease's substrate recognition, giving insights for the potential

224 31, but little is known about the structure, substrate recognition, or catalysis by family members.

225 cial role of the insertion domain in MvcA in substrate recognition.

226 A singular hydrophobic substrate recruitment site is exposed at the spiral's se

227 ilic residue Cys-122 is S-sulfenylated after substrate reduction, which is then resolved by a conserv

228 s, while o-methylbenzaldehyde functionalized substrates required longer irradiation times and resulte

229 d the ER lumen and cytosol and an endogenous substrate resembling an alpha-helical TM.

230 lane lattice matching between Li and the rGO substrate, resulting in planar Li deposition.

231 f DNA and RNA polymerases along their duplex substrates results in DNA supercoiling.

232 The process shows broad substrate scope and delivers complex, chiral homoproparg

233 This method features a broad substrate scope and good functional group tolerance, and

234 The extension of the substrate scope of mTG beyond canonical amines thus subs

235 formation pathway, created by expanding the substrate scope of the carboxylic acid reductase toward

236 We examined the substrate scope using substituted aromatic and aliphatic

237 We uncover that this substrate selectivity is based on the ability of nestin

238 t, a serious heart valve defect, affects the substrate selectivity of ADAM17 toward Heparin-binding e

239 in contrast to many other proteins that use substrate selectivity to preferentially interact with sp

240 These molecular substrates sensitize cardiomyocytes to spontaneous Ca(2+

241 Substrate sequences C-terminal to the dephosphorylation

242 hagy(4,5), is phosphorylated by mTORC1 via a substrate-specific mechanism that is mediated by Rag GTP

243 delineate the evolution of methyltransferase substrate specificities and modification patterns in rRN

244 we showed that these four CEKs have distinct substrate specificities in vitro.

245 ignature that is potentially responsible for substrate specificity and catalytic selectivity of C4H.

246 provide a structural explanation for varied substrate specificity and ion transport ratio among CCCs

247 cysteine protease legumain exhibits a strict substrate specificity for cleavage after asparagine and

248 s position modulate inhibitor efficiency and substrate specificity leading to drug resistance is uncl

249 ate that mycobacterial EHs may have a narrow substrate specificity providing a potential explanation

250 We find that the SNF2 domain couples substrate specificity to an ATPase step essential for DN

251 ubiquitin ligases and, thus, regulate their substrate specificity, ligase activity, and subcellular

252 on transport kinetics (K(m) and V(max)) and substrate specificity.

253 acid as a chiral pool starting material and substrate stereocontrol to establish the five contiguous

254 Our results show that substrate stimulates ATP hydrolysis by accelerating the

255 x responsible for the maturation of multiple substrates, such as Abeta.

256 For more challenging substrates, such as secondary sulfamides, the reaction e

257 The relative reactivity of various substrates supports the proposed mechanism, as does a TE

258 parameters including type of mixing solvent, substrate temperature, particle concentration, and assem

259 minimal length scale for the patterns in the substrate that depends on tau/tau(D) and can be much lar

260 s have been defined using a limited panel of substrates that aberrantly occupy the channel.

261 ehydes and active methylene group containing substrates that affords multifunctional naphthalenes, ph

262 ue to the use of reaction schemes and probes/substrates that are not sensitive to the diverse range o

263 biosynthesis and the chemical nature of the substrates that are translocated by the MmpL transporter

264 Here, we identify the conditions and substrates that decouple the cycloaddition from subseque

265 ivated 1,2-disubstituted alkenes, a class of substrates that has not readily undergone copper-catalyz

266 Heck hydroarylation of alkenyl benzaldehyde substrates that proceeds under mild conditions.

267 Engineered DNA substrates that stabilize a reaction intermediate by mim

268 For the oxygen-tethered substrates, the reaction can proceed at room temperature

269 te via hydrogen atom transfer (HAT) from the substrate to the photoexcited TAC radical dication, thus

270 d structural fold but act on a wide range of substrates to catalyze reactions involved in bioluminesc

271 ng assay to study the binding of ssrA-tagged substrates to ClpXP.

272 ion between endogenous and newly-encountered substrates to influence the evolutionary trajectory, an

273 atform based on poly(ethylene terephthalate) substrates to which polyacrylate-based sensing and polym

274 The structures show that both substrate translocation and release involve movements of

275 nnel lining, with implications for gating or substrate translocation.

276 ow was automated and applied to characterize substrate transport kinetics and to test 294 top-markete

277 During simultaneous feeding on the different substrate types, Fe deficiency triggers a hierarchy in s

278 Our result offer insight into a key step in substrate ubiquitination by a member of the largest ubiq

279 Michaelis complex of the enzyme and natural substrate undergoes which align the nucleophile for effi

280 litated by changes in protein abundances for substrate uptake and initial catabolism.

281 n alternate tool to study methanogenesis and substrate use in particular.

282 fore reperfusion, improves myocardial energy substrate use, and preserves mitochondrial structure and

283 containing peptides to organic and inorganic substrates using single-molecule force spectroscopy (SMF

284 types, Fe deficiency triggers a hierarchy in substrate utilization, which is facilitated by changes i

285 terest is driven by a realization that their substrate versatility and their ability to engage in int

286 belled post-translationally modified protein substrates via simultaneous sensing of both chemo- and s

287 For short-degron protein substrates, we show that unfolding can occur directly fr

288 ally drawing SnSe into a flexible fiber-like substrate, which is polycrystalline, highly flexible, ul

289 This ability allows Rrp6p to target diverse substrates while avoiding a subset of RNAs.

290 that USP(4207) sequesters KATms from diverse substrates whose activities are down-regulated by acylat

291 and is triggered by the interaction of a Tat substrate with the Tat receptor complex.

292 destined for transfer and couples the nicked substrate with the VirD4-like substrate receptor.

293 stion by combining topographically patterned substrates with atomic force microscopy (AFM).

294 nism by which NIS transports different anion substrates with different stoichiometries has remained u

295 n and H/D exchange in a number of additional substrates with favorably positioned bases.

296 The ability to pattern OCCs on solid substrates with high spatial precision and molecularly d

297 Modification of cellular substrates with linear polyubiquitin chains is a key reg

298 d allows for the orthogonal acetalization of substrates with reactive, acid-sensitive functional grou

299 ngle-crystal hybrid perovskites on arbitrary substrates, with precise control of their thickness (fro

300 tions tested is modulated by the presence of substrates, with the majority becoming less accessible i