ライフサイエンスコーパス: substrate-specific

1 dc20 inhibition by the spindle checkpoint is substrate specific.

2 Notably, AKT signaling in melanoma cells is substrate specific.

3 or one or more cdks, but none is known to be substrate specific.

4 to dsx shows that the requirement for Doa is substrate specific.

5 eins is ordered, occasionally redundant, and substrate-specific.

6 these effects were both enzyme-specific and substrate-specific.

7 amatic change upon PKA phosphorylation was a substrate-specific, 7-fold increase in both K(m) and k(c

8 ing of how transmembrane interactions govern substrate-specific a disintegrin and metalloproteinase p

9 different catalytic strategies to accomplish substrate-specific acetylation.

10 These enzymes are both tissue and substrate-specific across all three organisms.

11 equiring mechanisms for tight repression and substrate-specific activation.

12 We show here that resveratrol is a substrate-specific activator of yeast Sir2 and human Sir

13 d Cdh1 proteins were identified as limiting, substrate-specific activators of APC-dependent proteolys

14 es toward a tyrosine-phosphorylated TCR zeta substrate (specific activity ranging from 0.23 to 40 pmo

15 lation turnover to generate clearly resolved substrate-specific activity thresholds, which in turn en

16 ytic subunit uses unique elements to mediate substrate-specific activity, and use NAT-type specific a

17 cells before gastrulation; and third, it has substrate-specific activity, cleaving Xnr1, Xnr2, Xnr3 a

18 ADAM10 complexes may allow cell type- and/or substrate-specific ADAM10 targeting.

19 stabilization of each loop conformation and substrate-specific adaptation of the active site.

20 n domain containing 13 (KCTD13) protein is a substrate-specific adapter for cullin3-based E3 ubiquiti

21 KCTD13 encodes a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3-u

22 odel of S2P substrate specificity in which a substrate-specific adapter protein tethers the S2P to it

23 LHL40, an E3 ubiquitin ligase cullin3 (CUL3) substrate-specific adapter protein, result in severe con

24 lin 3a (CUL3a) in the cytoplasm, likely as a substrate-specific adapter protein.

25 x, Tramtrack, and Bric-a-brac) protein, is a substrate-specific adaptor for Cullin3-RING ubiquitin li

26 ntains the stability of the Pcu1p-associated substrate-specific adaptor protein Pop1p.

27 es in which we propose that ETO1 serves as a substrate-specific adaptor protein.

28 of a large family of BTB-domain proteins as substrate-specific adaptors for C. elegans CUL-3.

29 BTB-Kelch proteins are substrate-specific adaptors for cullin-3 (Cul3) RING-box

30 roteins, which modulate protein stability as substrate-specific adaptors for ubiquitination, have bee

31 F-box family of proteins, which function as substrate-specific adaptors of Cul1-based ubiquitin liga

32 However, the substrate-specific adaptors of this ligase remain unchar

33 e expression or the function of select F-box substrate-specific adaptors that results in neoplastic c

34 ltisubunit E3 ubiquitin ligases that recruit substrate-specific adaptors to catalyze protein ubiquity

35 the Kelch-like protein family, which acts as substrate-specific adaptors to Cullin E3 ubiquitin ligas

36 ligases often use repeat domain proteins as substrate-specific adaptors.

37 ls5p-Als6p constructs, the regions mediating substrate-specific adherence were localized to the N-ter

38 ive Hsp104 activity, we elucidated enhanced, substrate-specific agents that counter proteotoxicity un

39 n of PPO-catalyzed reactions are shown to be substrate specific and can be quantitatively accounted f

40 to show that the outcome of Spy's action is substrate specific and depends on its relative affinity

41 i from diverse environments, we defined both substrate-specific and core microbial components of the

42 Nevertheless, stereoselectivity is highly substrate-specific and for most substrates and OCTs, the

43 e findings represent the integration of both substrate-specific and global regulatory systems, and ma

44 whereas the ADP-ribosylation by ExoS is poly-substrate-specific and includes Ras as an early target f

45 This reconstitution is substrate-specific and is reminiscent of the SC35-mediat

46 We find rates are substrate-specific and obey predictions of classical nuc

47 gates, indicating that SUMO deconjugation is substrate-specific and plays a critical role in determin

48 inct NXF variant proteins carry out separate substrate-specific and tissue-specific RNA regulation.

49 The requirement for this RS domain is substrate specific, and correlates with the strength of

50 The activity of each HalM enzyme is substrate-specific, and the assay products exhibit antim

51 ern blot analysis using a phosphorylated Akt substrate-specific antibody of Akt immunoprecipitated fr

52 KA upon exposure to EJ, as detected by a PKA substrate-specific antibody.

53 the Hsp90 molecular chaperone system to the substrate-specific arm of SCF ubiquitin ligase complexes

54 upon protein tyrosine phosphorylation and is substrate specific, as it is induced by vitronectin and

55 of a cargo to protect its adaptor is adaptor substrate-specific, as adaptors with artificial degradat

56 rotein ratios decreased with age, suggesting substrate-specific barrier regulation.

57 lant higher eukaryotes and inconsistent with substrate-specific base excision repair mechanisms found

58 wever, the action of Ras/NORE1A/beta-TrCP is substrate-specific because IkappaB, another substrate of

59 y state for both substrates while displaying substrate-specific behaviors.

60 ith the MAPK binding linear motif to achieve substrate specific binding, and it also enables co-recru

61 Together, these studies suggest that substrate-specific binding by sirtuin proteins involves

62 ted to play a particularly important role in substrate-specific binding by the sirtuin proteins.

63 nus) domain ubiquitin ligases occurs through substrate-specific binding domains.

64 nths prior to death, to evaluate region- and substrate-specific binding of the highly fluorescent PiB

65 witching may involve the removal of an early substrate-specific binding site as a mechanism to exclud

66 tural variability in regions associated with substrate-specific binding.

67 eart at different FXN levels, and focused on substrate-specific bioenergetics and stress signaling.

68 Although substrate-specific carbohydrate transporters and hydrola

69 y a tyrosine finger motif, thereby providing substrate-specific catalytic activity.

70 For example, the formation of substrate-specific cavities within bulk silica, while co

71 ced folate carrier (RFC1) resulted in marked substrate-specific changes in folate binding and the ind

72 ity Functional Theory) identifies the highly substrate-specific changes required to improve laccase d

73 eate across the outer membrane do so through substrate-specific channels proteins.

74 herefore, we hypothesize that, in analogy to substrate-specific channels that evolved to bind certain

75 These data provide further evidence for the substrate-specific chaperone function of FlgN and FliT a

76 The data suggest that FliS acts as a substrate-specific chaperone, preventing premature inter

77 les and identify one set of sodium-dependent substrate-specific chemical shifts.

78 robiome, and mechanisms of site-specific and substrate-specific citrullination.

79 GIT1-betaPIX, which CRL3-KLHL4 exploits as a substrate-specific co-adaptor to recognize and monoubiqu

80 elevated expression of F-box Skp2 protein, a substrate-specific component of SCF (Skp1-Cullin-F box p

81 ble to isolate M77 of Adx alpha helix-3 as a substrate-specific contact towards CYP11A1.

82 holesterol and vitamin D3, and whether these substrate-specific contacts are important for CYP11A1 mo

83 o take substrates into account for potential substrate-specific control of MMP1 activity in the futur

84 port that these functions depend on SPOPL, a substrate-specific CUL3 adaptor.

85 hemical assays, pathogenic Lon proteins show substrate-specific defects in ATP-dependent proteolysis.

86 ions that abolish kinase activity or display substrate-specific defects in specific pathways, such as

87 transport of at least two substrates showed substrate-specific defects in transport.

88 ible connection between MsRH2-1 function and substrate specific degradation via the ubiquitin pathway

89 Substrate-specific degradation is a key feature of the u

90 BAG6 and inhibiting its capacity to promote substrate-specific degradation.

91 chondrial energy fluxes evaluated, including substrate-specific dehydrogenase activities, respiratory

92 er stability of the PP1-PPP1R15A complex nor substrate-specific dephosphorylation.

93 activation and therefore was probably due to substrate-specific differences in transporter/substrate

94 es, despite its sequence similarity to broad-substrate specific dioxygenases that do.

95 nzyme produced in Escherichia coli is highly substrate specific, displaying a strict requirement for

96 Substrate-specific DNA binding activity was detected in

97 pment of protein kinase inhibitors targeting substrate specific docking sites, rather than the highly

98 ound that the Hex3.Slx8 complex has a robust substrate-specific E3 ubiquitin ligase activity.

99 uitin-conjugating enzyme, and, frequently, a substrate-specific E3 ubiquitin-protein ligase.

100 actions without relying on photocatalysts or substrate-specific EDA complexes and opens new avenues f

101 These data suggest a substrate-specific effect such that certain mutations ar

102 with telomerase, rather than it being a DNA substrate-specific effect.

103 The substrate-specific effects of the W217A mutant correlate

104 to investigate the general function and the substrate-specific effects of the YER motif.

105 This substitution had highly substrate-specific effects ranging from transport reduce

106 hat LGMDD1 GF domain mutants in Sis1 exhibit substrate-specific effects, influenced by Hsp70 activity

107 UPS activity, many of which had pathway- or substrate-specific effects.

108 Y361 exhibited substrate-specific effects.

109 These results support the role for a substrate specific electrostatic interaction between the

110 ining hydroxylation, and identify additional substrate-specific elements that contribute to distinct

111 -CoA synthase (KCS) gene family catalyze the substrate-specific elongation of VLCFAs.

112 Mus81 is a highly conserved substrate specific endonuclease.

113 These experiments revealed a substrate-specific energetic barrier to cpTat-mediated t

114 Structures of AAD-1, an (R)-enantiomer substrate-specific enzyme, in complexes with a phenoxypr

115 nformational landscape of promiscuous versus substrate-specific enzymes.

116 These proteins exhibit a blend of substrate specific exo- and endonuclease activities and

117 s FlgN and FliT have been proposed to act as substrate-specific export chaperones, facilitating incor

118 n multiple SCF complexes involving different substrate-specific F-box proteins that are involved in d

119 oting complex (APC), in association with its substrate-specific factor Cdh1.

120 romoted SCF-mediated polyubiquitylation in a substrate-specific fashion.

121 ptidase activity of individual subunits in a substrate-specific fashion.

122 We suggest that FlgN and FliT are substrate-specific flagellar chaperones that prevent oli

123 By tagging synaptic proteins with a peptide substrate specific for CaMKII and expressing them in cul

124 )-Ala(12)] angiotensin I is an ACE-resistant substrate specific for chymase.

125 inhibition of prenylation of Ki-Ras, HDJ2, a substrate specific for FPTase, and Rap1A, a substrate sp

126 substrate specific for FPTase, and Rap1A, a substrate specific for GGPTase-I.

127 7) (S)-BEL, a chiral enantiomer of suicidal substrate specific for iPLA2beta, could be effectively u

128 We also propose a new substrate specific for PR3.

129 Since pp120 is the first identified substrate specific for the insulin vis-a-vis the IGF-1 r

130 that nanoparticles conjugated with a peptide substrate specific for the serine protease granzyme B, w

131 l)butyl]guanine ([(18)F]FHBG), a radioactive substrate specific for the sr39TK PET reporter protein.

132 o 2-cyano-6-aminobenzothiazole and a peptide substrate specific for the tumor-overexpressed enzyme fu

133 rine protease activity against a fluorogenic substrate specific for TLSPs.

134 e activities in phosphorylating an exogenous substrate specific for ZAP-70 and Syk kinases.

135 protein system which allows for a variety of substrates (specific for MRI, florescence, or protein pu

136 Addition of excess unlabeled substrates specific for 10 distinct mammalian P-450 subf

137 e preparation was active against fluorogenic substrates specific for cathepsin D and E and inactive a

138 c for cathepsin D and E and inactive against substrates specific for cysteine cathepsins.

139 cence polarization assay against fluorogenic substrates specific for MMPs or TLSPs.

140 Transfected switch substrates specific for mu-->gamma3 and mu-->gamma1 are

141 Its effects on protein turnover are substrate-specific, for unknown reasons.

142 arcina acetivorans, and have also identified substrate-specific functional roles for cyt c during met

143 ur results reveal an unanticipated degree of substrate-specific functionality encoded in N-terminal s

144 romiscuous GSTA1-1 that is not observed with substrate-specific GSTA4-4.

145 The substrate-specific H-bonding interactions play a critica

146 Each H/ACA RNP contains a substrate-specific H/ACA RNA and four common proteins, t

147 Target substrate-specific hammerhead ribozyme cleaves the speci

148 Some connections were substrate-specific, highlighting the value of the rapidl

149 efficient conversion of activated PP2A into substrate-specific holoenzymes, thus minimizing unregula

150 that most transport systems are exquisitely substrate specific, how are diverse protein sequences re

151 e, to lessen off-target effects, we engineer substrate-specific Hsp104 variants.

152 This effect of spermine was substrate specific; i.e. with casein as substrate, sperm

153 Remarkably, the substrate-specific increase in activity caused by T-loop

154 a result, these mutants not only regain the substrate-specific induction on catabolic arginine and h

155 Substrate-specific inhibition of C99 cleavage is desirab

156 herefore prove to be a valuable compound for substrate-specific inhibition of other RecQ family helic

157 Substrate-specific inhibition of the proteasome has been

158 s phosphorylation is inhibited by heparin, a substrate-specific inhibitor of CK2.

159 kely applicable for the development of other substrate-specific inhibitors as well.

160 n help in the discovery of ADAM isoform- and substrate-specific inhibitors.

161 the development of therapeutically valuable substrate-specific inhibitors.

162 ought about by the reversible interaction of substrate-specific inner-membrane proteins with an outer

163 dings fill an important gap in understanding substrate-specific inside-out signal transfer along clea

164 ods, the affinity method based on the enzyme-substrate specific interaction between amylase and glyco

165 e lifetime is achieved by the phosphorylated substrate-specific interaction with a bifunctional ligan

166 To find the structural elements that provide substrate-specific interactions and to allow identificat

167 tion e can be evaluated as the difference of substrate-specific isotope ratios between inflow and out

168 bind ions, the modification of the QDs with substrate-specific ligands or receptor units, and the ch

169 rocytes secondary to an up-regulation of its substrate-specific light chain, xCT, and that this occur

170 hese data demonstrate that BB0646 is a broad substrate specific lipase that contributes to lipolytic

171 pH influenced CBL affinity isolation in a substrate-specific manner that paralleled pH effects on

172 translocon and demonstrate that it acts in a substrate-specific manner to facilitate the initiation o

173 n compartmentalization can be modulated in a substrate-specific manner to generate biologically signi

174 and SSB that modulate helicase activity in a substrate-specific manner with little effect on overhang

175 rs was found to vary as much as 60-fold in a substrate-specific manner, an unexpected finding for act

176 nverted repeats of salmonid transposons in a substrate-specific manner, and it mediates precise cut-a

177 be turned off with a galactose analogue in a substrate-specific manner, indicating that galactose cat

178 etero-oligomers, however, was modulated in a substrate-specific manner, presumably due to the specifi

179 tment shifts cellular energy metabolism in a substrate-specific manner, spares pyruvate carbon from o

180 te the anaphase-promoting complex (APC) in a substrate-specific manner, there is no evidence that the

181 236 residue increases protease activity in a substrate-specific manner, while Gly244 has an overall n

182 proteins into the endoplasmic reticulum in a substrate-specific manner.

183 he anaphase-promoting complex/cyclosome in a substrate-specific manner.

184 f, can phosphorylate exogenous proteins in a substrate-specific manner.

185 various physiological functions largely in a substrate-specific manner.

186 ctivates or represses editing in a stage and substrate-specific manner.

187 is possible to inhibit gamma-secretase in a substrate-specific manner.

188 stabilizing SIRT1/peptide interactions in a substrate-specific manner.

189 tylation and internal modifications in a NAT substrate-specific manner.

190 slation during ER stress, inhibits RIDD in a substrate-specific manner.

191 ein-1/tolloid-like proteinase activity, in a substrate-specific manner.

192 hway involving multiple membrane-associated, substrate-specific mannosyltransferases (ManTs) responsi

193 hagy(4,5), is phosphorylated by mTORC1 via a substrate-specific mechanism that is mediated by Rag GTP

194 ent targets only partially overlap, implying substrate-specific mechanisms of HuC-mediated splicing r

195 How mitochondrial shape and substrate-specific metabolism are related has been a dif

196 cleavage of EGF ligands can involve the same substrate-specific metalloprotease but does require diff

197 doxin (Adx), but the structural basis of the substrate-specific modulation towards Adx is not known.

198 unction toward RagC/D, resulting in impaired substrate-specific mTOR-dependent phosphorylation of TFE

199 We propose that Rrp47p functions as a substrate-specific nuclear cofactor for exosome activity

200 ealkylation activities, including regio- and substrate-specific O-demethylation and O,O-demethylenati

201 olvement of this protein in the catalysis of substrates specific of the anaerobe cytoplasm of DvH.

202 in angiosperms and gymnosperms, mediated by substrate-specific OMTs, represents one of the fundament

203 Substrate-specific outer membrane channels of gram-negat

204 The presence of efflux pumps and substrate-specific outer-membrane porins in Pseudomonas

205 active molecules at electrodes modified with substrate-specific oxidative enzymes.

206 into the active pocket of CYP9Q1, a broadly substrate-specific P450 with high quercetin-metabolizing

207 ta therefore characterize Ubxn7 as the first substrate-specific p97 cofactor regulating replisome dis

208 provides a basis for regulation of an mTORC1 substrate-specific pathway and a roadmap to discover MiT

209 ics reveals that these enzymes assemble into substrate-specific pathways requiring about 100 enzymes

210 to additional ERAD substrates to interrogate substrate-specific pathways.

211 r dialysis with 5 microM MLCK(11-19)amide, a substrate-specific peptide inhibitor of MLCK, markedly r

212 The unique ability to interchange substrate-specific peptides into the linear self-assembl

213 nzyme for mannitol biosynthesis, is a highly substrate-specific phosphatase and, accordingly, represe

214 onist dose-dependent cAMP/PKA activities for substrate-specific phosphorylation dictated by dual regu

215 PP1-interacting proteins (PIPs) to generate substrate-specific PIP/PP1 holoenzymes, but the lack of

216 assemble modularly-i.e., by a simple sum of substrate-specific primary degrader modules, one for eac

217 Such substrate-specific properties of signals were evolutiona

218 ions that are critical for the catalytic and substrate-specific properties of the IMP-1 enzyme.

219 We predict that substrate-specific protease-accessibility-regulation con

220 ns, acting as a scaffolding protein and as a substrate-specific protease.

221 ns, we briefly exposed inside-out patches to substrate-specific proteases.

222 establish a versatile platform for analyzing substrate-specific proteasome function and indicate that

223 In P. aeruginosa, the largest family of substrate-specific proteins is the OccD (previously repo

224 s, the ubiquitin-proteasome system regulates substrate-specific proteolysis during the cell cycle, ap

225 not calpain 2, in mouse hearts demonstrated substrate-specific proteolytic activity under basal cond

226 strated that polyarginine potently inhibited substrate-specific proteolytic cleavage by furin.

227 altered mitochondrial function, and ordered, substrate-specific proteolytic events.

228 egradation of oxalic acid is catalyzed, in a substrate-specific reaction, by oxalate decarboxylase (O

229 o accelerate conventional reactions, perform substrate-specific reactions, and manipulate regio- and

230 2 (S phase kinase-associated protein 2), the substrate-specific receptor of the ubiquitin ligase resp

231 ation, and identifies important residues for substrate-specific recognition and acetylation by NatB e

232 Y substrate binding lipoprotein that dictate substrate-specific recognition and has revealed which di

233 olecular mechanisms of how E3 ligases confer substrate-specific recognition, and their role in substr

234 Cyp4f14-null mice exhibited substrate-specific reductions in liver microsomal vitami

235 Cdc20 and Cdh1/Hct1, have been identified as substrate-specific regulators for APC-dependent proteoly

236 -terminally located ~70 amino acid core of a substrate-specific regulatory subunit (PPP1R15A/GADD34 o

237 f parallel experimentation to develop novel, substrate specific results.

238 ines a recognition motif for the assembly of substrate-specific RING/cullin 3/BTB ubiquitin ligase co

239 other gram-positive bacteria have a similar substrate-specific role.

240 dly reduced (by 30%); these results indicate substrate-specific roles for His(91) and Phe(84).

241 no reaction is operationally simple, robust, substrate specific, selective and high yielding.

242 reover, inhibition of TGase-modified htt was substrate-specific since overall TGase activity in the s

243 implications for the rational design of new substrate-specific SIRT1 modulators.

244 gest that cleavage results from binding at a substrate-specific site.

245 cs and deduce that this behavior arises from substrate-specific stabilization of a conformational cha

246 The application of substrate-specific stable isotope tracers has permitted

247 any breakthroughs, there are limitations to 'substrate-specific' stable isotope tracers, which limit

248 The recombinant substrate-specific subunit LhaS accepted heme from diver

249 In sum, our study establishes neo-substrate-specific targeted protein degradation via KLHD

250 As C-1 Sec7 was much less substrate-specific than cytohesin-1, it appears that str

251 nto the role of stable isotope tracers, from substrate-specific to novel D2 O approaches, in facilita

252 Ketoconazole (KET) and quinidine (QIN), substrates specific to cyt P450 3A enzymes, were used to

253 of fecal contamination, were detected using substrates specific to enzymes produced by each species.

254 n of the 7-amino-4-methylcoumarin (AMC) from substrates specific to thrombin or plasmin was monitored

255 structure is not what one would expect of a substrate-specific transmembrane channel, leading us to

256 of two ATP-binding cassette-type ATPases, a substrate-specific transmembrane protein (S component) a

257 tems use related outer membrane proteins for substrate-specific transport across the outer membrane.

258 Numerous studies have sought to characterize substrate-specific transport by NSTs; however, the avail

259 dL, which may provide an explanation for the substrate-specific transport of TodX and TbuX observed w

260 pled transport, but the mechanism underlying substrate-specific transport rates is still not understo

261 single metal ion is mediated by two or more substrate-specific transport systems.

262 is indeed reflected in protein investment in substrate-specific transporters and enzymes, this is not

263 , leading to loss of functional gigaxonin, a substrate specific ubiquitin ligase adapter protein nece

264 -associated degradation due to their role in substrate-specific ubiquitination, which is required for

265 ield models that explain 68 to 86 percent of substrate-specific variation in editing levels.

266 ort pyruvate into the TCA cycle in an energy substrate specific way.

267 Activation is substrate specific, with a smaller effect noted for reti