ライフサイエンスコーパス: substructure

1 ) in an ANCOVA with an adjustment for hidden substructures).

2 graphically correlated fine-scale population substructure.

3 o confounding due to population admixture or substructure.

4 e genetically too different, e.g. population substructure.

5 rt to control for relatedness and population substructure.

6 to admixed populations and populations with substructure.

7 eleton featuring a 3-azabicyclo[3.1.0]hexane substructure.

8 r, genotyping array, and population genetics substructure.

9 n used in bioinformatics to infer population substructure.

10 12) contains a rare 1,2-3,4-bis-epoxydecalin substructure.

11 ransfer hydrogenation catalysts with Cp*IrCl substructure.

12 ck of clear biomarkers for its heterogeneous substructure.

13 itochondrial sequences indicate an east-west substructure.

14 role of "functional aggregation" in nuclear substructure.

15 are both colocalized in the same chloroplast substructure.

16 ely robust against the effects of population substructure.

17 of IDO1 inhibitors based on a benzimidazole substructure.

18 heir distributions, obscuring or eliminating substructure.

19 combinations of lipid A and oligosaccharide substructures.

20 onvergent construction of type II polyketide substructures.

21 fs with biochemically or chemically relevant substructures.

22 mall subsets now linked through their common substructures.

23 to the lipid A and core oligosaccharide (OS) substructures.

24 hout clear overlapping with specific nuclear substructures.

25 of trypanosome nucleoporins to discrete NPC substructures.

26 by combining DOXO with appropriate H2S donor substructures.

27 that alter proper functionality of valvular substructures.

28 o obtain structurally similar structures and substructures.

29 or taxa to visualize and discover community substructures.

30 rgent means of assembling Type II polyketide substructures.

31 s with 71 manually delineated structures and substructures.

32 vendors, specific physical properties or any substructures.

33 insic conformations of the three trapezoidal substructures.

34 e divergent, while type 2 demonstrated novel substructures.

35 2 of the noduli, and 4 innervating multiple substructures.

36 that combines quinolizidine and indolizidine substructures.

37 vel SG proteins and characterize distinct SG substructures.

38 of its proteomic effects in multiple limbic substructures.

39 fine needle aspiration biopsies, and tissue substructures.

40 lly characterised and evaluated for possible substructures.

41 pocampus and amygdala into their constituent substructures.

42 venient and general approach to access these substructures.

43 argely focused on elucidation of the lipid A substructures.

44 This compound consists of a chromophore substructure 1,7-diazaheptamethin.

45 ontacts are formed between a specific set of substructures, after which folding proceeds downhill in

46 The M31 halo also contains coherent stellar substructures, along with a smoothly distributed stellar

47 A substructure analysis of the cocrystallized PDE ligands

48 RV-NPL is robust to population substructure and admixture, inclusion of nonpathogenic v

49 equately control for population admixture or substructure and analyze pedigrees with missing genotype

50 staining, while the FS method often revealed substructure and cellular staining specificity.

51 ollisionless CDM predict halos with abundant substructure and central densities that are too high to

52 oup volumetric assessments were performed at substructure and composite substructures levels.

53 the p7 residue subtly alter the neighboring substructure and electrostatic properties of the HLA-DQ2

54 er pathological remodelling of cardiomyocyte substructure and function during heart failure (HF) refl

55 e and hexosamine modification of the lipid A substructure and further enabled derivation of a core ol

56 amples of these patterns include substantial substructure and heterogeneity in Hispanics/Latinos, iso

57 e sequences showed strong population genetic substructure and isolation by distance, suggesting local

58 Our study indicates ancient population substructure and local adaptation of Africans.

59 nd technical approaches help to untangle the substructure and projection patterns of the cerebellum.

60 ographic ancestry (BGA); however, population substructure and relatively recent admixture can make di

61 shes sub-nuclear localization in 13 distinct substructures and distinguishes between nuclear proteins

62 rised of intertwined stiff and weakly bonded substructures and exhibits intrinsically ultralow lattic

63 uctural diversity guided by incorporation of substructures and functional groups known to diminish li

64 , members of which possess distinct chemical substructures and necessitate deviating synthetic platfo

65 summarize here recent findings on nucleosome substructures and TF binding dynamics, and highlight how

66 tion can be mapped onto anatomically defined substructures and that detailed examination of substruct

67 ocalization of chemical reactions to network substructures and the identification of critical sites w

68 nsion, and interaction terms connecting drug substructures and the volume/charge of mutant residues a

69 derstanding of their nanometer-scale ciliary substructures and their disruptions in ciliopathies has

70 ties for analyzing RNA structures, including substructuring and search tools.

71 , but the rules that dictate their assembly, substructure, and coexistence with other liquid-like com

72 trong lensing events produced by dark-matter substructure, and compute it for 11 galaxy clusters.

73 (Phi(M) > 1) in the rate-determining loop 1 substructure, and conclusively identify mutations and po

74 xes--one axis is defined through a benzamide substructure, and the other axis is associated with diff

75 the testing of multiple markers, population substructure, and ultimately a requirement for replicati

76 these lesions cosegregate within the clonal substructure, and we have demonstrated that hyperdiploid

77 molecules, and strategies for accessing this substructure are important for developing therapeutic ca

78 ariance to assess whether xenobiotic-derived substructures are among the most-variant Mass2Motifs.

79 These substructures are assembled from chromophore-bearing phy

80 atrophy of specific retinal layers and brain substructures are associated over time, in order to furt

81 ch the fingers/palm/connection, thumb and RH substructures are connected by flexible (disordered) lin

82 Proteins localized in these substructures are important to understand the interior n

83 Discrete substructures are likely to be important to RNA-protein

84 The observed cluster substructures are more efficient lenses than predicted b

85 tical coherence tomography-reflective drusen substructures are optical coherence tomography-based bio

86 nges in cell-based assays combined with drug substructures are predictive of KI-induced cardiotoxicit

87 Organic micropollutants containing aniline substructures are susceptible to different light-induced

88 ct ligand bioactivities and to recognize key substructures associated with GPCRs through the coupling

89 esults suggest that neuronal circuitry has a substructure at far higher resolution than is typically

90 We document high genetic substructure between northwestern and southeastern hunte

91 We validate the differential prevalence of substructures between two distinct samples groups and ap

92 We observed genetic substructuring between Ecuador and West Africa and betwe

93 rsecs are associated with the most prominent substructures, but some are part of the smooth halo(13).

94 Following construction of the hydro-indene substructure by means of a Pauson-Khand reaction, endgam

95 Substructures can help make highly diverse sequence data

96 Thus, mini-protein substructures can only rarely be derived from natural te

97 the interaction mode of the aryloxymethylene substructure cannot be assimilated to that of benzodioxa

98 his charge redistribution modifies the Li(+) substructure causing Li(+) ions to bind more strongly to

99 the natural structural barriers (chromoplast substructure/cell wall) and of the phases (soluble/insol

100 n of a superlattice, we observe a persistent substructure characterized by inter-bubble spacings simi

101 ur tree features include the number of small substructures (cherries, pitchforks) in the trees, measu

102 s the alpha-allyl-alpha,alpha-difluoroketone substructure, complementary palladium-catalyzed decarbox

103 the overall secondary structure into smaller substructures composed of a single base-pair stack, whic

104 Cell walls and chromoplast substructures constitute natural structural barriers gov

105 y linear global features and dendritic local substructures contrary to randomly hyperbranched systems

106 functional networks may contain hierarchical substructures corresponding with more specific cognitive

107 cific precision RSFC to test whether network substructures could be identified in 10 healthy human br

108 Ultimately, such substructuring could be useful for RNA 3D structure pred

109 e identified compounds as a starting point a substructure directed search against CHEMBL Database rev

110 ngle fibres, with a double helical repeating substructure displaying small variations in adhesive for

111 (-)-Englerin A features high substructure dissimilarity to known ligands for voltage-

112 In this material, the guest substructure does not exhibit three-dimensional ordering

113 erdominance is not supported, and population substructure does not explain the observed haplotype fre

114 e-domain interactions globally such that all substructure-domain contributions to drug-target interac

115 GIFT was then implemented to predict substructure-domain interactions based on drug repositio

116 ons, or GIFT, is proposed herein to evaluate substructure-domain interactions globally such that all

117 Eighteen of the top 100 predicted combined substructure-domain interactions had corresponding drug-

118 tomic heralds such as RPE changes and drusen substructure emergence detectable 1 to 2 years before GA

119 of the mouse vomeronasal organ, an olfactory substructure essential for social recognition.

120 e used for PCA and adjustment for population substructure, estimating homozygosity rates in individua

121 Te2, with interlocked rigid and weakly bound substructures, exhibits lattice thermal conductivity as

122 proteins FliM and FliN, whereas an analogous substructure for the closely related non-flagellar (NF)

123 lass of materials with quasi-one-dimensional substructures for various applications.

124 mouse retinas and reveal previously unknown substructures formed by resident proteins.

125 s been applied to the synthesis of important substructures found in natural products and biologically

126 vantage of SED lies on its ability to detect substructures from long ECFPs which significantly improv

127 new method (LocNuclei) that predicts nuclear substructures from sequence alone.

128 among distal residues, dissecting individual substructures from the context of folded proteins result

129 Stellar substructures from the first epoch are gone, but those f

130 estimation to better decompose mixture model substructure; fuzzy clustering to better identify substr

131 2-8Neu5Ac and Neu5Gcalpha2-6Galbeta1-4GlcNAc substructures; Galbeta and GlcNAcbeta terminal substruct

132 hybridization approach using two privileged substructures gave instant access to a new series of tan

133 oducing enhancements to automate learning of substructured genomic mixtures, with specific emphasis o

134 An (E)-iminium vinylogous substructure has been shown as the common cation scaffol

135 For both the lipid A and core OS substructures, HCD and UVPD produced highly informative

136 ing biclusters which are the most meaningful substructures hidden in gene expression data remains a h

137 ottleneck (small ROHs) and recent population substructuring (highly homozygous individuals).

138 is modulated by ECD binding to peptidoglycan substructures, however, the molecular mechanisms underpi

139 aneous and mediated by four specific protein substructures; (ii) the ability of PITPalpha to initiate

140 These substructures impede productive folding and can serve as

141 mary cilia are ubiquitous mammalian cellular substructures implicated in an ever-increasing number of

142 The cascade builds the full cephalotaxine substructure in a single operation in 60 % yield.

143 re, providing further support for population substructure in Asia [8] and suggesting that this persis

144 An alkyne substructure in each candidate small molecule enables af

145 ll type deconvolution by taking advantage of substructure in genomic mixtures via a strategy called s

146 pproach for the identification of population substructure in high-density genotyping data/next genera

147 slands sampled here indicate little regional substructure in MC1R.

148 ussing on the role and targeting of vacuolar substructure in plant immunity and pathogenesis.

149 ructure; fuzzy clustering to better identify substructure in sparse, noisy data; and automated model

150 ying driver mutations and delineating clonal substructure in three different human tumor data sets.

151 e their effectiveness in identifying mixture substructure in true breast cancer CNV data from the Can

152 nes, especially chiral amines, are prevalent substructures in a wide range of natural products and dr

153 abled their application as stains of vesicle substructures in confocal fluorescence microscopy imagin

154 e potential applications of these privileged substructures in drug discovery, efficient, atom-economi

155 ituted 1H-indazoles are useful and important substructures in many pharmaceuticals.

156 -Dihydrobenzofurans and indolines are common substructures in medicines and natural products.

157 with beta-stereogenic centers are important substructures in pharmaceuticals and natural products.

158 ve astronomical units that show four annular substructures in the disk of the young (less than 500,00

159 tary disks are known to possess a variety of substructures in the distribution of their millimetre-si

160 ions of the four images provide evidence for substructures in the lensing galaxy.

161 erentially on different types of copolymeric substructures in the plant cell wall, possibly because t

162 Although population substructuring in P falciparum has resulted in clonal ou

163 These substructures, in turn, support putative de novo structu

164 st-variant Mass2Motifs to xenobiotic-derived substructures including paracetamol/acetaminophen mercap

165 that label small subsets of neurons in brain substructures, including known and novel cell types.

166 roups and heteroatoms to the spiroadamantane substructure increased the solubility and metabolic stab

167 erreflective foci, and OCT-reflective drusen substructures independently predict geographic atrophy (

168 s via external interactions with neighboring substructures, indicating that subdomain interactions ca

169 urate, largely at the expense of leaving out substructures inside the nucleus making a fine-grained a

170 resentations may reveal underlying community substructures invisible in 2D representations.

171 al immune responses, the presence of deposit substructure is an important indicator of underlying hem

172 The alpha-carboxy-tropone substructure is ideal for this purpose as the proton can

173 subjects are related and whether population substructure is present.

174 (i.e., local unfolding of previously folded substructures is required when moving from the unfolded

175 he expected object size (e.g., organs, organ substructures, lesions, or voxels).

176 were performed at substructure and composite substructures levels.

177 ide chains and defined small molecule ligand substructures (ligand fragments) observed in the Protein

178 We found that chimpanzee population substructure makes genetic information a good predictor

179 ch extracts biochemically relevant molecular substructures ("Mass2Motifs") from a collection of fragm

180 ch extracts biochemically relevant molecular substructures ("Mass2Motifs") from spectra as sets of co

181 pectrum, characteristic fragment, and common substructure matches.

182 developed characteristic fragment and common substructure matches.

183 Such selection and the emerging substructure may affect treatment-based intervention str

184 tical coherence tomography-reflective drusen substructures may be a clinical entity helpful in monito

185 nce with the principle that ventral striatum substructures may cooperate to guide motivated behaviors

186 ere examined using the automated hippocampal substructure module in FreeSurfer 6.0.

187 of embedded CF3 substituents within organic substructures necessitates the development of diverse me

188 ynthesis of diverse collection of privileged substructures needed for a drug design and discovery cam

189 ves, covering elemental composition, typical substructures, neutral losses, and adducts, InterpretMSS

190 Multiple annular substructures observed towards disks at young ages can a

191 tical coherence tomography-reflective drusen substructures (ODS) and examine their associations with

192 likelihood-based method for determining the substructure of anomalously scattering atoms in macromol

193 re this behavioural symptom by examining the substructure of apathy in ALS and to determine the relia

194 e hierarchical and laminated, similar to the substructure of bone, superior crack resistance can be r

195 To quantify the substructure of FAs, we developed a clustering method ba

196 ted detachment of chromatin from the nuclear substructure of freshly isolated, unfixed cells, followe

197 th the templates D-glucuronic acid (GlcA), a substructure of hyaluronan, and N-acetylneuraminic acid

198 roisoquinoline (THIQ) moiety is a privileged substructure of many bioactive natural products and semi

199 ameter and sensing of dynamic changes in the substructure of myelin at nanoscale.

200 The terphenyl substructure of the chiral cyclophane natural product ba

201 and differentiation, and explain the clonal substructure of tumors.

202 cture-function analysis and requirement of a substructure of U6atac 3' stem-loop in U12-dependent in

203 linical trajectories, and pathophysiological substructures of ASD.

204 quantitative way to elucidate supramolecular substructures of cellulose and their impact on enzyme ac

205 ones that strictly respect the known spatial substructures of IT ("face patches") did not improve pre

206 ve neuroimaging methods and demonstrated the substructures of it using other approaches in an animal

207 Spatial visualization of proteins in substructures of rat brain, and in human ovarian cancero

208 We found METTL5 expression in various substructures of rodent and human brains and METTL5 prot

209 sequencing has enabled reconstructing clonal substructures of somatic tissues from frequency and cooc

210 et interactions, such as those involving the substructures of synthetic drugs and protein domains, is

211 nderlies an "electrical circuit" between two substructures of the adult rat hippocampus consisting of

212 eal both the morphological and compositional substructures of the cell walls.

213 0 bilateral pairs of neurons innervating all substructures of the central complex exhibit orcokinin i

214 rocess, the chaperone HJURP protects various substructures of the dimer, serving both as a folding an

215 xpresses a repertoire of enzymes that target substructures of the glycosaminoglycans with variable su

216 In this study, we synthesized the exact substructures of the LM glycans that consist of an alpha

217 ts for transition-state structure within all substructures of the WW domain fold (hydrophobic core, l

218 ll 3 patients with hematologic neoplasms had substructure on electron microscopy.

219 ll 3 patients with hematologic neoplasms had substructure on electron microscopy.Part-2: Whereas ligh

220 The half bridge is a SPB substructure on the nuclear envelope (NE), playing a key

221 f ppiGReMLIN to point out relevant conserved substructures on protein-protein interfaces, we compared

222 involvement in MDD is confined to principal substructures only.

223 ase separated, reminiscent of stress granule substructure or nanoscale liquid droplets.

224 gnoring the competitive effects of different substructures or domains, but this could lead to high fa

225 ed multi-molecular structures, such as viral substructures or intact viruses.

226 0.045, respectively), OCT-reflective drusen substructures (P = 0.004 and P = 0.03, respectively), an

227 dataset of RNA tertiary (3D) structures and substructures plus a web-based search tool-designed to e

228 We found that protein substructures preceding conserved rare codons tend to ha

229 t HS causes deconstruction of all centrosome substructures primarily through degradation by centrosom

230 e chemistry; however, most reactions of this substructure proceed through reactive intermediates pron

231 d data set of 153 drug pairs, we showed that substructure profiles are useful in predicting synergy.

232 present a computational framework that uses substructure profiles derived from the molecular structu

233 CA2 to CA4 were the only substructures reduced in first-presentation depression.

234 Super-resolution microscopy reveals stable substructures, referred to as cores, within stress granu

235 lows molecules to be grouped based on shared substructures regardless of classical spectral similarit

236 QSM could make a potentially useful tool for substructure-resolved in vivo habenula imaging, and prov

237 t-based search on rich metadata and chemical substructure search allow precise identification of desi

238 t is, a lectin-glycoprotein interaction, via substructure search and the knowledge of site-specific g

239 harmacophore search followed by docking, and substructure search resulted in five additional ligands.

240 It is tightly bound to the latter via a substructure search tool that maps each ligand to full s

241 for lead optimization based on perfect match substructure search, (iv) re-rank virtual screening resu

242 tational algorithm to perform maximal common substructure searches on chemical binders for each targe

243 fibres, each with a double helical repeating substructure, separated by a central gap of 8-10 nm in w

244 ding sites may bind to similar drugs, the 3D substructure similarity data can be used to identify sim

245 for rapidly identifying whole organ and some substructure staining, while the FS method often reveale

246 ware packages are widely used in analysis of substructure: Structure and Eigenstrat.

247 Excluding molecules with substructures such as five-membered rings from training

248 biomolecules containing a push-pull nitrogen substructure, such as bioamines, amino acids, and peptid

249 ctionally and anatomically distinct cortical substructures, such as areas or layers, contain differen

250 ion relationship between amygdala anatomical substructures, supporting the use of network analysis te

251 ations of 41 clusters from the Local Cluster Substructure Survey.

252 much higher resolution picture of population substructure than it can be obtained with existing metho

253 e Drosophila brain is a central complex (CX) substructure that harbors circumferentially laminated ri

254 producing a unique inorganic-organic hybrid substructure that reinforced the multilayered architectu

255 biomaterial assembled into a solid organoid substructure that reorganized the extracellular matrix c

256 rves as a repository for both small molecule substructures that are significantly associated with eac

257 e alpha to ketones leads to the formation of substructures that are ubiquitous in natural products, p

258 However, more detailed and refined substructures that determine host tropisms are still not

259 currence in the gut have indicated community substructures that may reflect functional and metabolic

260 ein secretion machine is composed of several substructures that organize into a holostructure or inje

261 resent tetrahedral equivalents to the biaryl substructures that overpopulate synthetic libraries.

262 In one substructure, the fan-shaped body, automated analysis re

263 g are used to characterize the properties of substructures-the small-scale distribution of dark matte

264 of volume reduction in principal hippocampal substructures: the cornu ammonis (CA1-CA4), dentate gyru

265 unction of EDAL resides in a 56-nt antiviral substructure through which its 18-nt helix-loop intimate

266 ally flexible 1-benzyl-1-phenylsemicarbazide substructure to fill the EBP.

267 t that N-trifluoromethyl azoles are valuable substructures to be considered in medicinal chemistry.

268 ws the texture of large samples with complex substructures to be scanned and opens up the conceptual

269 specific chromatin segments contact nuclear substructures to mediate this organization.

270 (iv) interpretation of possible fragment ion substructure using an internal database, (v) annotation

271 rovided an accurate prediction of population substructure using variants with a minor allele frequenc

272 n can drive the formation of dynamic droplet substructures (vacuoles) with tunable lifetimes.

273 bstructures and that detailed examination of substructure volumes is now possible, we examined differ

274 sonance imaging brain scans (including brain-substructure volumetrics) were performed annually.

275 initial hydroarylation process, the oxazole substructure was deconstructed using a [4 + 2]/retro-[4

276 The same PAINS substructure was often found in consistently inactive an

277 However, by directly measuring substructures, we show clearly that the bending in the s

278 vian-origin viruses; sulfated Neu5Acalpha2-3 substructures were associated with the binding of human-

279 dose-distribution parameters of the cardiac substructures were collected from three-dimensional comp

280 xtensively tested compounds containing PAINS substructures were detected, and their hit rates were de

281 CBMs) that preferentially bind to cellulosic substructures were fluorescently labeled.

282 Combinations of different chemical substructures were included since they may function as o

283 ino ozonides with cycloalkyl and heterocycle substructures were superior to their acyclic counterpart

284 a compartment composed of novel fibril-like substructures, which we identify here by three-dimension

285 ty of crystals contain quasi-one-dimensional substructures, which yield distinctive electronic, spint

286 an effectively dissociate the complexes into substructures while preserving the native topological in

287 The analysis allows us to isolate molecular substructures, whose presence allows molecules to be gro

288 tes to give medicinally relevant fluorinated substructures with complete regiocontrol.

289 been shifting their attention towards these substructures with the help of fluorescence techniques.

290 At a finer geographic scale, the genetic substructure within the Central sorghum population is as

291 Moreover, a dual substructure within the first highstand suggests tempora

292 myloid load, in addition to the detection of substructures within single amyloid plaques correlating

293 y and high resolution, the identification of substructures within single amyloid plaques, and the qua

294 lidus, putamen, superior temporal gyrus, and substructures within thalamus (lateral dorsal, ventral a

295 y interference and could excellently resolve substructures within the brain.

296 nets (PNNs) are conspicuous neuron-specific substructures within the extracellular matrix of the cen

297 with each enzyme displaying specificity for substructures within these glycosaminoglycans that displ

298 bstructures; Galbeta and GlcNAcbeta terminal substructures, without sialic acid branches, were associ

299 ggests that it has more than one cooperative substructure yielding two separate unfolding transitions

300 y is applicable to the imaging of organellar substructures, yielding a 3D localization precision of ~