ライフサイエンスコーパス: subtherapeutic

1 when the international normalized ratio was subtherapeutic.

2 ntrations were consistently documented to be subtherapeutic.

3 renchyma by the IV, IT or IVT routes will be subtherapeutic.

4 d the baseline dosage of acyclovir to become subtherapeutic.

5 R348 10 mg/kg was subtherapeutic.

6 ) to determine the effect of therapeutic and subtherapeutic (0-1 cm H(2)O) nasal continuous positive

7 We describe the effects of feeding a subtherapeutic (50 g/ton of feed) and therapeutic (200 g

8 ere assigned to either therapeutic (n=59) or subtherapeutic (59) nCPAP (about 1 cm H(2)O pressure) fo

9 eated with 1 month's therapeutic (n = 15) or subtherapeutic adaptive servoventilation.

10 al vertebrate species, we proposed that such subtherapeutic administration alters the population stru

11 Concentrations correlated with subtherapeutic and therapeutic blood levels.

12 Subtherapeutic and therapeutic R507 and R545 doses prolo

13 Subtherapeutic anti-IL-6 antibody level or treatment ces

14 Administration of subtherapeutic antibiotic therapy increased adiposity in

15 We generated a model of adiposity by giving subtherapeutic antibiotic therapy to young mice and eval

16 Low-dose (subtherapeutic) antibiotics can enhance energy availabil

17 To prevent supratherapeutic or subtherapeutic anticoagulation, these patients must be i

18 Status epilepticus etiologies included subtherapeutic antiepileptic drugs (43%), alcohol or oth

19 More patients with therapeutic vs subtherapeutic ART had resistance (n = 73): no major mut

20 Absence of NRTI mutations and subtherapeutic ART preswitch were associated with failur

21 Nonadherence, suggested by subtherapeutic ART with/without major resistance mutatio

22 Random, irrational, subtherapeutic artemisinin doses and self-medication wit

23 outside the typical range, most (89%) being subtherapeutic at <12 mug/mL.

24 ensured participants remained protected from subtherapeutic atazanavir concentrations.

25 Therapeutic drug monitoring showed subtherapeutic azole concentration in 32 of 90 (36%) cas

26 We hypothesized that subtherapeutic beta-lactam antibiotic exposure, determin

27 s) were used to determine therapeutic versus subtherapeutic beta-lactam antibiotic exposure.

28 Therapeutic and subtherapeutic beta-lactam use is associated with differ

29 time more than twice the control time) with subtherapeutic bivalirudin anticoagulation (activated pa

30 redictable exposure and higher likelihood of subtherapeutic blood concentration than does IV administ

31 djuvant therapy enabled the use of typically subtherapeutic carboplatin doses without decreasing effi

32 comparison to a monkey that received sCR1 + subtherapeutic CCS (rejected at 11 days) and a control t

33 MRSA pretreated with subtherapeutic ceftaroline-carbapenem therapy revealed t

34 Subtherapeutic CNI concentrations were common in the fir

35 y, and withdrawal of the azole may result in subtherapeutic CNI concentrations.

36 n level, and effectiveness of ceftazidime or subtherapeutic colistin to treat the infections were ass

37 Subtherapeutic colistin was shown to efficiently clear t

38 Carboplatin was delivered at the subtherapeutic concentration of 62.5 microg.

39 ut significantly enhanced Treg generation at subtherapeutic concentrations (P<0.01).

40 Lumefantrine concentrations suggested subtherapeutic concentrations in at least 2 cases.

41 Combined RAPA and IVIG at subtherapeutic concentrations inhibits cell proliferatio

42 Agricultural use of antimicrobials in subtherapeutic concentrations is increasing in response

43 treat or prevent tuberculosis can result in subtherapeutic concentrations of antiretroviral drugs.

44 in with these LA formulations will result in subtherapeutic concentrations of both drugs.

45 ptide killing assays on MRSA pretreated with subtherapeutic concentrations of ceftaroline and carbape

46 ated gene transfer results in persistent yet subtherapeutic concentrations of factor IX and requires

47 han in women with HIV not on ART, leading to subtherapeutic concentrations of MPA in 12% of women, su

48 reptogramin, virginiamycin, has been used at subtherapeutic concentrations to promote the growth of f

49 after several weeks to months and lingers at subtherapeutic concentrations up to 3 years after therap

50 Exposure to some InSTIs, even at subtherapeutic concentrations, can induce adverse effect

51 drug choice, have an increased likelihood of subtherapeutic concentrations, leading to a higher risk

52 At subtherapeutic concentrations, second-generation InSTIs

53 of caseum creates spatiotemporal windows of subtherapeutic concentrations.

54 self-reported health status compared with a subtherapeutic control.

55 - allograft recipients treated with a brief, subtherapeutic course of cyclosporin A maintained their

56 Third we assessed whether a subtherapeutic course of cyclosporine would potentiate e

57 d with blocking anti-MCP-1 mAb plus a brief, subtherapeutic course of rapamycin had long-term islet a

58 toadjusting CPAP (4-20 cm H(2)O) or group B) subtherapeutic CPAP (pressure fixed at 4 cm H(2)O).

59 Compared with results without CPAP, subtherapeutic CPAP did not affect any measured polysomn

60 ate the effects of autoadjusting CPAP versus subtherapeutic CPAP treatment over 6 months on NAFLD act

61 Subtherapeutic CsA and RS-61443 monotherapy groups devel

62 Addition of FTY720 therapy to a subtherapeutic CsA immunosuppressive regimen delays the

63 cant difference was noted in the presence of subtherapeutic CSA or FK levels (15.4% vs. 13.9%, P=NS).

64 Subtherapeutic cutoffs were: rifampicin <8 ug/mL, isonia

65 The described dosing schedule resulted in subtherapeutic daclizumab levels in liver transplant rec

66 optimization of therapy and avoid periods of subtherapeutic delivery kinetics.

67 metabolizers will experience more prolonged subtherapeutic dolutegravir concentrations.

68 when donor sMHC were combined with a single subtherapeutic dosage of cyclosporine.

69 pointing results so far, in part, because of subtherapeutic dosage used in clinical studies.

70 to show that piceatannol, when combined with subtherapeutic dosages of CsA, prevents graft rejection,

71 RAPA at a subtherapeutic dose of 0.1 mg/kg worsened glucose metabo

72 Finally, a subtherapeutic dose of anti-CD154 Ab or CTLA4-Ig, which

73 However, mice treated intermittently with a subtherapeutic dose of benzylpenicillin had significantl

74 Treatment of animals with BX471 and a subtherapeutic dose of cyclosporin (2.5 mg/kg), which is

75 days after transplantation with or without a subtherapeutic dose of cyclosporine.

76 on immunosuppression, the combination at the subtherapeutic dose of each drug may be synergistically

77 follow-up, small sample size, and a possibly subtherapeutic dose of etanercept.

78 A subtherapeutic dose of local radiotherapy in combination

79 ntravenously administered saline or a single subtherapeutic dose of MP (5 mg/kg) as the parent drug (

80 (allograft) immunosuppression with a single subtherapeutic dose of MP delivered as a liver-targeted

81 In contrast, the subtherapeutic dose of ropinirole generated only modest

82 The subtherapeutic dose of ropinirole improved the use of pr

83 These data support the use of the subtherapeutic dose of ropinirole in a chronic model of

84 MOPC-315 tumor bearers when combined with a subtherapeutic dose of the chemotherapeutic agent melpha

85 oups: saline; carboplatin (31.25 mug/20 muL, subtherapeutic dose); 2-DG (250 mg/kg); 2-DG (500 mg/kg)

86 02), which included four patients treated at subtherapeutic doses and 24 patients treated at 960 mg t

87 on therapy with CsA + RS-61443 at these same subtherapeutic doses developed acute rejection (P < or =

88 bits lymphocyte proliferation, was tested at subtherapeutic doses in combination with cyclosporine (C

89 Treatment with subtherapeutic doses of a MEK-1/2 inhibitor delayed arth

90 The collateral effects of feeding subtherapeutic doses of antibiotics to agricultural anim

91 The combined adoptive transfer of subtherapeutic doses of both TRP1-specific TCR transgeni

92 2) Subtherapeutic doses of CsA do not prolong allograft sur

93 nted to Lewis or control dark agouti rats on subtherapeutic doses of cyclosporin.

94 ll function in vitro and, when combined with subtherapeutic doses of cyclosporine (CsA), prolongs all

95 nt effects of delivered vIL-10 alone or with subtherapeutic doses of cyclosporine A (CsA) on paramete

96 more pronounced effects in combination with subtherapeutic doses of DEX.

97 Exposure to subtherapeutic doses of linezolid for 10 weeks did not i

98 However, when administered with subtherapeutic doses of opioids or the enkephalinase inh

99 Combination treatment with subtherapeutic doses of Peg IFN-alpha 2a and Nutlin-3 in

100 Therapeutic and subtherapeutic doses of R507 (60 and 15 mg/kg 2 times pe

101 Subtherapeutic doses of rapamycin plus TIM-1-specific an

102 he potent inhibition of CYP3A4 by ritonavir, subtherapeutic doses of ritonavir are used to increase p

103 common tertiary structure and inhibition by subtherapeutic doses of the antibipolar drug lithium.

104 ics in vitro and potentiated the efficacy of subtherapeutic doses of these drugs in vivo in murine PD

105 within the first 3 months of treatment or on subtherapeutic doses were excluded.

106 ts receiving antidepressants were prescribed subtherapeutic doses, and two (18%) of the 11 who were p

107 of a triple-drug regimen using each agent at subtherapeutic doses, namely BQR (2.0 mg/kg/q.o.d.), CsA

108 At subtherapeutic doses, neither anti-ST2L mAb nor CpG alon

109 g antimitotic regimens, enabling efficacy of subtherapeutic doses.

110 rations that routinely use antimicrobials in subtherapeutic doses.

111 hat when mice were administered intermittent subtherapeutic dosing of benzylpenicillin, the strain wi

112 owever, treatment failure, noncompliance and subtherapeutic dosing were often reported.

113 Fifty-five percent (n = 44/80) had subtherapeutic drug concentrations preswitch.

114 Drivers are overall antifungal use, subtherapeutic drug levels at sites of infection/coloniz

115 Subtherapeutic drug levels can be caused by poor adheren

116 reakthrough event are underlying disease and subtherapeutic drug levels.

117 successive cycles of inactivation induced by subtherapeutic exposure to aBL.

118 aches - which include microdosing - evaluate subtherapeutic exposures of new drugs in first-in-human

119 Underdosing and subtherapeutic exposures were more common among malnouri

120 Our results suggest that subtherapeutic expression levels of near full-length, me

121 linical trials have suffered from transient, subtherapeutic expression of human fVIII transgenes.

122 es of 1.5 to 2.5 times the control value are subtherapeutic for most modern aPTT reagents.

123 1.30-1.97) anticoagulation compared with the subtherapeutic group (12%).

124 overy compared to baseline than those in the subtherapeutic group.

125 There was a trend for the subtherapeutic groups to have higher vascular scores.

126 of MCP-1 binding to CCR2 in conjunction with subtherapeutic immunosuppression can have profound effec

127 uto- or allotransplantation, with or without subtherapeutic immunosuppression to temporarily characte

128 The fluconazole concentration was considered subtherapeutic in 40% of the patients.

129 INR was subtherapeutic in 47.4% of ischemic stroke patients and

130 niazid, and pyrazinamide concentrations were subtherapeutic in 85%, 29%, and 13%, respectively, at mo

131 Rifampicin concentrations were subtherapeutic in most Indian patients taking a thrice-w

132 international normalized ratio (INR) levels: subtherapeutic (INR <2), therapeutic (INR, 2-3), and sup

133 , paroxysmal atrial fibrillation (OR: 5.19), subtherapeutic international normalized ratio (OR: 7.37)

134 and 3 ischemic strokes, all in patients with subtherapeutic international normalized ratio.

135 Subtherapeutic lenalidomide concentrations controlled th

136 ering continuous positive airway pressure to subtherapeutic levels for 3 minutes during non-REM sleep

137 The long half-life and persistence of subtherapeutic levels of AZM may result in selection of

138 However, in the presence of subtherapeutic levels of CsA, graft survival time was si

139 Moreover, in mice treated with subtherapeutic levels of immunosuppressive drugs, the re

140 ith a gamma-globin/MGMT vector initially had subtherapeutic levels of red cells expressing gamma-glob

141 No subtherapeutic levels were observed postpartum.

142 Additional preliminary studies suggest that subtherapeutic levels, including microlevels of lithium,

143 closporine, one of which was excluded due to subtherapeutic levels.

144 eared safe, circulating F.IX levels remained subtherapeutic (< 1%).

145 wed by a subrenal capsular implantation of a subtherapeutic mass of 25 islets from young (3 months) o

146 were randomly assigned therapeutic NCPAP or subtherapeutic NCPAP (about 1 cm H2O) for 1 month.

147 not significantly, from 20.0 to 23.5 min on subtherapeutic NCPAP (between treatments p<0.005).

148 therapeutic NCPAP, and from 15.0 to 13.0 on subtherapeutic NCPAP (between treatments, p<0.0001).

149 107 men entered the study: 53 received subtherapeutic NCPAP and 54 therapeutic NCPAP.

150 Subtherapeutic NCPAP did not alter the overnight number

151 Therapeutic NCPAP was superior to subtherapeutic NCPAP in all primary outcome measures.

152 lood pressure by 2.5 mm Hg (SE 0.8), whereas subtherapeutic nCPAP increased blood pressure by 0.8 mm

153 ed with the most robust control intervention subtherapeutic nCPAP.

154 leep apnoea compared with a control group on subtherapeutic NCPAP.

155 d vitality were 1.68 (therapeutic) and 0.97 (subtherapeutic) NCPAP (between treatments p<0.0001).

156 artificially low or high doses resulting in subtherapeutic or adverse effects.

157 tion in five individuals with clear skin and subtherapeutic or supratherapeutic drug concentrations;

158 osis is crucial to prevent toxic effects and subtherapeutic or supratherapeutic drug dosing.

159 e day of transplantation in conjunction with subtherapeutic oral cyclosporine (CsA, 10 mg/kg/day, day

160 +10 posttransplantation in conjunction with subtherapeutic oral cyclosporine.

161 tal; two of these cases were associated with subtherapeutic partial thromboplastin time values.

162 eriphery, resulting in limited expansion and subtherapeutic peak concentrations.

163 was similar: 5.4 h (therapeutic) and 4.6 h (subtherapeutic) per night.

164 rior recovery of lung function compared with subtherapeutic PK and narrow spectrum antimicrobials.

165 Despite subtherapeutic plasma bNAb levels, 36% (4/11) in the pla

166 r in the 16 partially adherent patients with subtherapeutic plasma levels (N=13, 81%) than in the 46

167 Augmented renal clearance might lead to subtherapeutic plasma levels of drugs with predominant r

168 plasma levels than in adherent patients with subtherapeutic plasma levels.

169 Subtherapeutic prophylaxis was frequent but rarely repor

170 In one recipient with subtherapeutic RAD blood levels on day 7 posttransplant,

171 a 2-log decline in plasma MTX levels to the subtherapeutic range within 5 minutes of CPG2 administra

172 When combined with a subtherapeutic regimen of rapamycin, CXCR3-173 mAb induc

173 mination over what is expected, resulting in subtherapeutic renally eliminated drug concentrations.

174 These results confirm that subtherapeutic RS-61443 + CsA combination therapy is eff

175 ated diabetes reversal post engraftment of a subtherapeutic SC-islet dose into mice.

176 eutic stimulation settings (active group) or subtherapeutic stimulation settings (control group) for

177 mbined treatment with low-dose rapamycin and subtherapeutic T(reg) numbers on the development of tran

178 Transient subtherapeutic tacrolimus concentrations may induce acut

179 indow may result in allograft dysfunction as subtherapeutic tacrolimus levels predispose to episodes

180 ion had a statistically greater incidence of subtherapeutic tacrolimus trough levels on postoperative

181 studies in drug development, individualized subtherapeutic tests of drug metabolism, carbon dating a

182 Among these patients, 46%, 35%, and 19% had subtherapeutic, therapeutic, and supratherapeutic admiss

183 Serial passage in subtherapeutic transferrin concentrations resulted in no

184 the active drug's exposure and translate to subtherapeutic treatment.

185 but the slow ester hydrolysis can result in subtherapeutic TTX release.

186 The placebo group had subtherapeutic ultrasound to the knee at an intensity of

187 Beginning in 2017, the subtherapeutic use of most antibiotic compounds for grow

188 erapy only (24.8% [95% CI, 24.3%-25.3%]), or subtherapeutic warfarin (25.8% [95% CI, 25.0%-26.6%]); u

189 therapy only (8.1% [95% CI, 7.8%-8.3%]), or subtherapeutic warfarin (8.8% [95% CI, 8.3%-9.3%]).

190 erapeutic anticoagulation; 12751 (13.5%) had subtherapeutic warfarin anticoagulation (INR <2) at the