ライフサイエンスコーパス: subtly

1 fer when dietary composition is varied, even subtly.

2 ain and the catalytic core that only changes subtly.

3 ds whose chemical behavior often differ only subtly.

4 from 2.66 A, but the Fe-P bonds only change subtly.

5 uring the interpretation of 20 normal and 20 subtly abnormal mammograms.

6 -discussed quasi-liquid layer on ice evolves subtly above the melting point into a quasi-ice layer at

7 mbrane changes indicate that the protein can subtly adapt to its environment without large structural

8 ion and by down-regulating motility, thereby subtly adjusting and maintaining energy usage and pmf.

9 -1D morphological transition was achieved by subtly adjusting the intermolecular forces.

10 able to tune tRNA suppression efficiency by subtly adjusting the tRNA sequence and inter-convert poo

11 In addition, NAC also subtly adjusts other cellular functions to keep pace wit

12 y influence herbivore fitness but might only subtly affect a third trophic level.

13 nds to LRP2 near the mutation cluster, might subtly affect development and could lead to autism-assoc

14 ermine whether polymorphisms exist that more subtly affect enzymes yet are augmentable in the same wa

15 se genes display defects in cell fusion that subtly affect mating efficiency.

16 s confirms that both N100Y and N100W mutants subtly affect the chemistry of the PLP.

17 Mutations in the CA-CTD domain of Gag which subtly affect the self-assembly of Gag abrogated RNA sel

18 ifferences observed between strains, but can subtly affect turns and certain beta-sheet components.

19 roanatomical structures may be profoundly or subtly affected by the interplay of genetic and environm

20 agar to folate in vegetative cells were only subtly affected in Arp2 phosphorylation mutants.

21 condensed mitotic chromosomes, its deletion subtly affected the nucleoplasmic distribution of the pr

22 t, mediolateral patterning is generally only subtly affected.

23 nscriptional activity of each genomic region subtly affects almost all others).

24 nalysis reveals that loss of an HMGN variant subtly affects expression of numerous genes in specific

25 enetic ablation of MNTB neurons in mice only subtly affects this ability by prolonging the minimum ti

26 Abeta(1-38) isoform, indicating that NSAIDs subtly alter gamma-secretase activity without significan

27 muscle by introducing parasitic losses, and subtly alter how musculoskeletal anatomy modulates muscl

28 neuropathy is caused by mutations that more subtly alter myelin structure and which probably disrupt

29 either N196K- or G301D-substituted U2AF2 can subtly alter splicing of representative endogenous trans

30 domain and that mutations at the P2 position subtly alter the conformation about this site.

31 ose that structural alterations in eIF2gamma subtly alter the conformation of Met-tRNA(i)(Met) on the

32 a mechanism of amino acid substitutions that subtly alter the conformation of NA in and around the ac

33 However, the removal of denaturant does subtly alter the distribution of backbone dihedral phi,p

34 do not affect the affinity of GR for DNA but subtly alter the electrophoretic mobility of the GR-DNA

35 ggests that, in some cases, the mutation may subtly alter the entire protein-RNA interface.

36 losed that differences around the p7 residue subtly alter the neighboring substructure and electrosta

37 ) small overall changes in conformation that subtly alter the nucleotide triphosphate binding site su

38 pecies than the rest of intron 4, and it may subtly alter the ratio of two mRNA splice forms.

39 ard point mutations at the same sites, these subtly altered amino acids preserve the wild-type voltag

40 onstruction of C. albicans strains that were subtly altered at the mating-type-like (MTL) locus, a cl

41 and enclosed ubiquinone-binding site, but a subtly altered global conformation related to changes in

42 Telomere sequences are subtly altered in est2-LT strains, but similar changes i

43 nnels and voltage-gated calcium channels are subtly altered in genetic disorders and mutations in the

44 uitous feature of brain organization that is subtly altered in some neurodevelopmental disorders, yet

45 The binding of PTB is subtly altered in the presence of the central domain (p5

46 Although grossly normal, these mice have a subtly altered proliferative phenotype, with increased c

47 memory deficits, impaired fine motor skills, subtly altered social interactions, and decreased dendri

48 eliminated the nucleosome-free gap but only subtly altered the distribution of SAGA.

49 Using unnatural amino-acid mutagenesis, we subtly altered the properties of this Trp to reveal spec

50 Replacing these residues subtly altered the protein-PEG interface and thermal unf

51 nscriptional profile of these Treg cells was subtly altered, with an overrepresentation of IRF4-depen

52 ever, their size and protein composition are subtly altered.

53 e segrosome interactively with ParG, thereby subtly altering centromere conformation.

54 ions, e.g., by imposing greater rigidity, by subtly altering certain side chain vectors, or by adjust

55 s the role played by CH...pi interactions in subtly altering conformational preferences of three-resi

56 stability by binding across CA molecules and subtly altering interhexamer interfaces remote to the li

57 ier observations that CQR can be overcome by subtly altering the CQ side-chain length.

58 Conversely, the sugar moiety subtly alters DNA interactions.

59 le, and chromatin organization in cells, and subtly alters its nuclear mobility.

60 We show that addition of HA subtly alters mechanical properties and structure of the

61 We predict that calcium subtly alters scruin conformation through its calmodulin

62 e show here that mutation of this Gln to His subtly alters the active site structure but preserves 30

63 g multiple low-energy conformations and only subtly alters the average conformation and orientation.

64 This neomorphic mutation subtly alters the DNA-binding preference of OCT2, leadin

65 anifest the symptoms of FXTAS, although more subtly and less often than their male counterparts.

66 However, these effects are only subtly and not significantly stronger for ERBSs in diffe

67 ted with IF1, the equivalent site is changed subtly and the enzyme is incapable of binding thiophosph

68 endings varied both between strains of mice (subtly) and between species (more dramatically).

69 ism neither shifted their gaze away nor more subtly averted their gaze to peripheral locations.

70 geting the membrane-located channel requires subtly balancing lipophilicity, activity, and aqueous so

71 n of production of short transcripts differs subtly between basal and enhanced transcription, indicat

72 The pathogenicity island, which varies only subtly between strains, is approximately 150 kilobases i

73 istical topography, specific energetic terms subtly bias the representative structures giving rise to

74 ily genes; and Dkk4 transgenic mice showed a subtly but appreciably modified claw phenotype.

75 Unexpectedly, this early response was subtly but significantly different in people older than

76 dings indicate that the Ser-700 polymorphism subtly but significantly sensitizes the calcium-binding

77 More subtly, but crucially, we find that the observed velocit

78 ay produce "silent" programming defects that subtly, but irrevocably, jeopardize life-long well-being

79 ial community composition and structure were subtly, but significantly, altered by fertilization, wit

80 e, irradiation time, and photon flux), IRMPD subtly, but significantly, outperforms resonant-excitati

81 dinary wires but rather, indirectly and more subtly by dynamical stability.

82 ficity for the two enzymes can be controlled subtly by manipulation of the privileged quinolone core

83 phenotypic differentiation was defined more subtly by nonrandom transcriptional network organization

84 emoval of extracellular Ca(2+), was enhanced subtly by raising extracellular [Ca(2+)] from 2 mm to 10

85 es, the inhibition modulated neuronal output subtly, by elevating spike threshold or altering firing

86 onic sensors need microstructures that offer subtly changeable EDL interfaces to boost sensitivity, w

87 These replacements subtly changed the chemistry of two amino acids, but the

88 ches, usually altered IH more distinctly and subtly changed the kinetics.

89 Multimodal imaging revealed subtly changed, decreased FAF while the choroidal archit

90 reduces free IAA content in roots, but only subtly changes free IAA content in tomato hypocotyls.

91 em can substantially alter these motions, by subtly changing mechanical properties such as body or le

92 ions in the mitochondrial proteome gained by subtly changing steady-state protein assembly, stability

93 ther substitution improved solubility, while subtly changing the ordering of polymer films.

94 92% (S)-2) using the same chiral catalyst by subtly changing the structure of the achiral boronic aci

95 cating advanced multifunctional materials by subtly combining contrasting multi-components.

96 e tendon, we fabricated a novel composite by subtly combining two contrasting components: NiTi shape-

97 gnetoencephalography studies, or may be more subtly composed of differentiated activity of individual

98 method to locate and align only those, often subtly, conserved patterns essential to the family as a

99 erous cis-acting sites, which therefore very subtly contribute to the regulation of the "switch".

100 f anti-oxidant genes (Nrf2, HO-1, and Keap1) subtly contributed in the overall improvement in NAFLD r

101 potential nucleophilic addition but also to subtly control the regiochemistry by preventing the C-2

102 ed that the C20orf54 rs13042395 genotype was subtly decrease the risk of ESCC (T vs. C: OR = 0.95; 95

103 morphism was significantly associated with a subtly decreased cancer risk in under-weight group and n

104 ty of fine roots produced by palisade grass, subtly decreased nitrate leaching potential through incr

105 ny genes, at the expense of smaller and more subtly defined populations.

106 roscopy that the curvature of the nanoribbon subtly depends on the ligand-ligand interactions at the

107 show that yeast nucleosomes are likely to be subtly destabilized as compared with nucleosomes from hi

108 exhibited by members of a homologous series subtly differ from one compound to another, which can im

109 be applicable to any mixture of complex and subtly different analytes for which nucleic acid-based r

110 ll agonists where binding modes will be only subtly different and confined to only one binding site.

111 Baseline synaptic responses in CA1 were only subtly different between the two MA groups, but long-ter

112 e first study which attempts to quantify the subtly different binding specificities of a transcriptio

113 eural Networks (ANNs), are able to recognize subtly different biological entities.

114 molecular recognition of highly complex and subtly different carbohydrates, followed by reactions at

115 iable C-terminal peptide residues and elicit subtly different CLR conformations.

116 ovative therapies that take advantage of the subtly different collagens that exist within the skin.

117 Finally, response vigor exhibited a subtly different collection of MF and MS influences.

118 ectrometry (IM-MS) measurements, distinguish subtly different conformational states for protein compl

119 r proteins interact with the same domain but subtly different contact points of P450MT2.

120 ntrol presentation of sugar functionality in subtly different contexts.

121 Moreover, we find that subtly different environmental conditions can lead to dr

122 ergoing a slow conformational exchange among subtly different environments.

123 tion in developing control over enactment of subtly different facial expressions and therefore skills

124 the nucleobase with the active site are only subtly different for G versus oxoG, hOGG1 fails to catal

125 gy of polyps from SMAD4 mutation carriers is subtly different from other JPS polyps, notably includin

126 at these analogues may have a mode of action subtly different from that of the parent drug artemisini

127 ears to have an overall conformation that is subtly different from that of the wild-type enzyme.

128 shared by all CD4 TCRs, and that it is only subtly different from the common orientation proposed fo

129 One of these morphologies was subtly different from the previously published 27-A-reso

130 signal sequence variations may correspond to subtly different functional properties.

131 tion' - genes encoding similar proteins with subtly different functions, such as olfactory receptors.

132 complexes in vivo, suggesting that they have subtly different functions.

133 ts in the formation of planar complexes with subtly different geometries.

134 Many glycoproteins contain populations of subtly different glycoforms; therefore, with stricter or

135 The left and right eyes receive subtly different images from a visual scene.

136 stablishing a clear role for ARBs, have been subtly different in distinct patient populations.

137 hat each snoRNA forms two different snoRNPs, subtly different in how the proteins are bound to the C/

138 -type enzyme, and the crystal structures are subtly different in the active sites of the D256E and wi

139 Muller cells are subtly different in the GFAP(-/-)vim(-/-) mouse retina b

140 rned to efficiently collect rewards from two subtly different linear tracks in virtual reality.

141 dominantly off-pathway oligomers, albeit via subtly different mechanisms.

142 s while HBV and CCMV capsids fit similar but subtly different models of nucleation-limited assembly t

143 whose nonequivalent packing is reflected in subtly different morphologies of the two protomers.

144 luster and/or NU-1000 structure may comprise subtly different numbers of these ligands.

145 have started to illuminate the multiple and subtly different pathways that animal viruses use to ent

146 led to generation of several substrains with subtly different phenotypes.

147 ge of systems with an ability to distinguish subtly different processes.

148 Chromatin immunoprecipitation revealed subtly different promoter targeting between the differen

149 pplications but is made challenging by their subtly different properties.

150 Both methods give comparable although subtly different results.

151 from mating naturally by their responses to subtly different sex pheromone isomers, (E)-12- and (Z)-

152 e the P-box region in discrimination between subtly different small molecules.

153 tspots in the same cell produced spikes with subtly different spatiotemporal voltage signatures, cons

154 cid catabolic pathways studied to date use a subtly different spectrum of decarboxylases from the fiv

155 light direction and body orientation evolved subtly different strategies and performed less robustly.

156 s located on prey or eggs bind single CRs in subtly different structural conformations to elicit spec

157 vely, which have the same stoichiometry, but subtly different structures.

158 issae to distinguish between surfaces having subtly different textures and shapes.

159 ), homosexual men tend to be infected with a subtly different variant of HIV-1 than intravenous drug

160 eadily interchanged or "shuffled" to produce subtly different variants with distinct molecular shapes

161 , PIPK1gamma and layilin in similar although subtly different ways.

162 A series of subtly different, designed substrate analogues based on

163 However, their stratification patterns are subtly different, with M4 dendrites positioned just dist

164 trol for it and, at once, to discern between subtly different, yet important, Eurasian sources (such

165 e neural code for letter strings may also be subtly different.

166 biochemical properties of these enzymes are subtly different.

167 ir underlying protofilament hierarchy may be subtly different.

168 ile kinematics of tethered walking flies are subtly different.

169 the structures of Yb2CdSb2 and Ca2CdSb2 are subtly different: Ca2CdSb2 has a layered structure built

170 the chemical bonding in the two compounds is subtly different; in the (Eu(1-x)Ca(x))(2)Ge(2)Pb struct

171 ess vast brain areas to identify diverse and subtly-differentiated morphologies.

172 These observations illuminate how subtly differing ligand preferences of competing metal i

173 ng site for E2F transcription factors and is subtly distinct from a canonical p53-transactivating ele

174 Cell-based assays revealed subtly distinct intracellular sites of NS1 localization

175 mixing approach opens the door to a range of subtly distinct materials for chemical and biological ap

176 Even subtly distinct structural isomers evoked posterior resp

177 no acids, peptides, and nucleotides yielding subtly distinct taste qualities.

178 that the precise alignment of substrates is subtly distorted.

179 In contrast, poorly responsive variants subtly diverged, revealing a partial restoration of prot

180 ind to BRCA2's two distinct PhePP motifs via subtly divergent binding pockets.

181 However, it represents an example of either subtly divergent or powerfully convergent evolution, bec

182 ated with previous learning can be delivered subtly during SWS to selectively enhance memory consolid

183 ce charge, were found to both decisively and subtly effect therapeutic efficacy.

184 Although single HSP90 mutants showed subtly elevated levels of lesions, double mutant analysi

185 not show abnormal pathology, but do display subtly elevated levels of the highly amyloidogenic 42- o

186 ce for independence comes from the fact that subtly elevating Mad2(MDF-2) levels bypasses the require

187 sitions the peptide main chain and generates subtly enhanced interactions between the analogue peptid

188 Canoe loss subtly enhances AJ planar polarity and dramatically incr

189 states, but the average conformation differs subtly, especially at the G34-I35 linkage and V27 side c

190 proliferation in vitro but in vivo may more subtly exploit the proliferative pathways provided by ly

191 mines cardiac repolarization, and HERG-G628S subtly facilitates the genesis and propagation of premat

192 rs recognized by PvdS orthologues may differ subtly from species to species.

193 This pattern differs subtly from that described previously in rats.

194 n NEUROG3 loss-of-function phenotype differs subtly from that in mice, but the reason for this differ

195 This behaviour differs subtly from that of seeds overwintered in the soil seed

196 ootprint of MAb E33 on the E protein differs subtly from that of the well-characterized DIII-LR MAb E

197 tationary gating kinetics that differed only subtly from that produced by agonist binding.

198 nvolved in the binding to MHC class I differ subtly from those involved in binding to class II protei

199 ally, central LZ FDCs constitutively express subtly higher CR2 membrane densities than peripheral LZ

200 suggests that latent T. gondii infection can subtly impair brain function and increase vulnerability

201 iar and non-familiar orientations, increases subtly in neurons that exhibit stimulus competition.

202 The two species differ subtly in phenotype and cannot be differentiated by mito

203 tion from pre-SMA to STN when choices differ subtly in reward values, allowing more time to choose th

204 oragog and intestinal epithelia but differed subtly in the kidneylike nephridial tubules; neither Zn

205 lecular oligonucleosome patterns that differ subtly in their relative abundance across epigenomic dom

206 f T cells by MHC-peptide ligands that differ subtly in their structure have largely been based on eit

207 evels of histone H3 K18 and K27 acetylation, subtly increased H3 K27me3 and unaltered overall levels

208 engineered dopaminergic PC12 cell lines with subtly increased levels of MAO-B mimicking those observe

209 We report an intervention that subtly increases the observability of public goods contr

210 Next, we show that subtly increasing the probability that similarly tuned s

211 n the smaller effect modifier loci that more subtly influence colour.

212 ges, where structural inequities continue to subtly influence opportunities and pairings of mentors a

213 many new questions, the answers to which may subtly influence our approach to the treatment of reject

214 udy provides evidence that maternal PCOS may subtly influence the neurodevelopment of the offspring,

215 fruit-flies suggest that very many genes can subtly influence the trait.

216 at WM performance in healthy subjects may be subtly influenced by functional differences in CRHR1 and

217 to which it translates to a higher BMI, was subtly influenced by socioeconomic standing in both wome

218 First, it subtly influences centriole length by counteracting the

219 imary role at only a handful of origins, but subtly influences initiation timing globally.

220 This approach, which subtly integrates coverage information into the procedur

221 More subtly, it can also infer a researcher's latent hypothes

222 es on CD4(+) T cell phenotypes, whereas PD-1 subtly limits CD8(+) T cell phenotypes.

223 Protein homeostasis is subtly maintained on the mitochondrial inner membrane an

224 The cycle time of the distractor actions was subtly manipulated across trials, and the cycle time of

225 Subtly manipulating the relative timing of Kenyon cell s

226 r work emphasizes that spatial structure can subtly mediate intraspecific competition and the effects

227 Our data showing that A(1)AR activation subtly mediates a proarrhythmic Ca(2+) entry through TRP

228 nal in translation in vivo but is presumably subtly misfolded.

229 to characterize how immune responses may be subtly modified by tissue context.

230 These subtly modified electrical properties may result in atyp

231 al infection model also indicated that Lrrk2 subtly modifies the inflammatory response.

232 h as boron (B) in powder metal catalysts can subtly modify catalytic properties, and the associated c

233 scopic picture of how helix sequence changes subtly modulate conformational fluctuations at each base

234 to reflectin-based films, which was found to subtly modulate reflectin thin-film reflectivity.

235 However, we also find that m(1)Psi can subtly modulate the fidelity of amino acid incorporation

236 Most strains possess factors that subtly modulate the host environment, increasing the ris

237 namics in RAS proteins and oncogenic mutants subtly modulate the interactions with their downstream e

238 thought to either strongly "drive", or more subtly "modulate" activity patterns respectively.

239 This mimicry can be subtly modulated by different social contexts.

240 , whose catalytic function in translation is subtly modulated by posttranscriptional modifications.

241 bservations highlight how local stability is subtly modulated by sequence to tune protein conformatio

242 s, possibly due to higher N demand, AM fungi subtly modulated NO3- leaching, decreasing losses by 54%

243 The D130I mutation subtly modulates the helical structure.

244 By subtly modulating these two types of interactions throug

245 rotein synthesis and may affect longevity by subtly modulating this pathway.

246 replicates to higher titers in vivo, and is subtly more virulent, than the parental virus.

247 ponses are lost in a mouse line expressing a subtly mutated alpha2AAR, D79N alpha2AAR, created by two

248 ement proceeds with high selectivity between subtly nonequivalent acetal oxygen atoms.

249 f HIV-1 are not identical but instead differ subtly on one of their ends.

250 line silicate frameworks are shown to depend subtly on the architectures of the organic species, whic

251 tend to change shape in a way that converges subtly on the flightless form.

252 mobility of DNA knots depends crucially and subtly on the physical properties of the gel and, in par

253 satisfied then the eventual outcome depends subtly on the strength of local superiority of one speci

254 of-function effects are dependent, sometimes subtly, on the nature and apparently the extracellular,

255 ination, they can also alter gene expression subtly or powerfully.

256 ight result in neighboring molecules packing subtly out of register, leading to premature crystal gro

257 Non-fluorescent alpha1(V) THP subtly perturbed amide NMR chemical shifts of MMP-12 not

258 To examine this link directly, we subtly perturbed electron transport chain function in th

259 overall expression of the Treg signature was subtly perturbed in T1D, but not T2D, patients.

260 The low-dimensional representation is subtly perturbed in the solvated phase relative to the i

261 the thermal stability of DJ-1 in solution by subtly perturbing the structure of DJ-1 without causing

262 More subtly, phylodynamic models indicate that widespread cro

263 By subtly positioning the side chains on the three residues

264 of blatantly presented issues, and 72.6% of subtly presented issues.

265 Subtly prompting people to think about accuracy had a ge

266 evealed a unique folate-binding mode; tMTHFR subtly rearranges its active site to form a distinct fol

267 provides a foundation for interpreting (and subtly redefining) commonly used quantities such as firi

268 embryos lacking B4galt1, NOTCH signaling is subtly reduced during somitogenesis.

269 ers has been restricted to recent reports of subtly reduced fluid-fluid transition temperatures.

270 eutrophil accumulation was unchanged or only subtly reduced relative to wild-type control mice.

271 wo similar genomes on a similar phenotype is subtly reflected in their genotypes: only 30 genes are d

272 The shape of the Sun subtly reflects its rotation and internal flows.

273 constitutes one of the most spectacular yet subtly regulated phenomena in cell biology.

274 and 3) throughout periods where the computer subtly removed active control over balance.

275 th the apposition of active-site domains and subtly repositions zinc-binding residues.

276 lu activity have played an important role in subtly reshaping the structure of primate genomes.

277 The precise magnitude of the bend is subtly sequence dependent (consistent with a curved gene

278 rganized according to similar principles but subtly shift from the "classic" ventral striatum to the

279 y onset diabetes of youth in whites presents subtly similar to type 2 diabetes in adults.

280 substantially different from T(EM) but only subtly so from T(N).

281 any MAPs, the HsCKK domain can differentiate subtly specific tubulin conformations to enable microtub

282 lity that excess adiposity may paradoxically subtly suppress hypothalamic-pituitary-gonadal function

283 as been unsuccessful because of the long and subtly symptomatic preclinical period, difficulties obta

284 receptors may influence spatial memory more subtly than previously thought.

285 More subtly, these early AD-linked calcium alterations also r

286 and alkynyl ligand electronics combine more subtly to drive the magnetism of the new complexes repor

287 in a heterogeneous TS ensemble that responds subtly to mutation or changes in the solvent conditions.

288 our studies, we show that race biases can be subtly transmitted via televised nonverbal behavior.

289 tiphase transport, in a highly selective and subtly triggered fashion and without clogging, has inspi

290 size of EP-PDI crystals, we find that we can subtly tune their crystal structure and thereby alter th

291 expression in response to synaptic input to subtly tune their firing properties.

292 equilibrating alkyl-palladium complexes were subtly tuned to form either a primary or trisubstituted

293 ich allows it to access and persist within a subtly unique niche of the memory compartment characteri

294 tion profile of the gamma HC subunit changed subtly upon Ca(2+) addition, suggesting that the entire

295 Saccharides are complex, subtly variable, and camouflaged by hydroxyl groups that

296 ntial for the [(HCDippN)(2) BO](-) ligand to subtly vary its electronic-donor capabilities is reveale

297 also suggests that other factors contribute subtly when the structure of the substrate is altered.

298 alters protein stability and misfolding only subtly, whilst changing Ser to Asn at codon 169 causes i

299 was revealed for producing errors that were subtly wrong.

300 duced by the TLR7 receptor agonist imiquimod subtly yet reproducibly decreases time to skin graft rej