ライフサイエンスコーパス: subtype

1 of other factors (such as HIV or aggressive subtypes).

2 ith cancer, considering age, sex, and tumour subtype.

3 cancer (TNBC) is an aggressive breast cancer subtype.

4 er (TNBC), the most aggressive breast cancer subtype.

5 hemes and high robustness of the mesenchymal subtype.

6 who met criteria for PPA but not a specific subtype.

7 cleotide exchange depending on the G-protein subtype.

8 N9, an avian H3N8, and a human seasonal H3N2 subtype.

9 e ALNs(-) were associated with the luminal A subtype.

10 , no clinical test can reliably diagnose the subtype.

11 n explored in developmental dyslexia nor its subtypes.

12 l premature menopause and gene-specific CHIP subtypes.

13 d clonal architecture differed among MDS/MPN subtypes.

14 ould ideally be specific for distinct glycan subtypes.

15 ster adult-onset diabetes patients into five subtypes.

16 nt as a collection of different histological subtypes.

17 breast cancer than in luminal A or luminal B subtypes.

18 operties previously associated with discrete subtypes.

19 gorithm was used to delineate neurocognitive subtypes.

20 d recurrence across individual subgroups and subtypes.

21 on among patients with different IBS symptom subtypes.

22 cer (BLBC) compared with other breast cancer subtypes.

23 mors that detects potentially targetable ICC subtypes.

24 itory neurons of parvalbumin or somatostatin subtypes.

25 urring as a multiplicity of species-specific subtypes.

26 xtended signatures of distinct breast cancer subtypes.

27 hways as promising targets for breast cancer subtypes.

28 t significantly differ between breast cancer subtypes.

29 ific antibody responses against 11 different subtypes.

30 might influence caries progression or caries subtypes.

31 underlie differences between Kabuki syndrome subtypes.

32 of these cells further divided them into 40 subtypes.

33 travital imaging of the different mural cell subtypes.

34 pecific high-risk subgroups or breast cancer subtypes.

35 rols the production of two specific neuronal subtypes.

36 requirements for annotating sequences as new subtypes.

37 on and their co-regulation in two major TGCT subtypes.

38 g African mammals are exposed to diverse IAV subtypes.

39 ristics displayed marked differences between subtypes.

40 olecular markers to better define GPe neuron subtypes.

41 there is no clinical diagnostic test for CMS subtyping.

42 been widely applied in the context of tumour subtyping.

43 rrelated negatively with illness duration in Subtype 1 (r = -0.201, P = 0.016) but not in Subtype 2 (

44 The cannabinoid receptor subtype 2 (CB2R) represents an interesting and new thera

45 P1 subtype 2 (P1-2) was the predominant P1 subtype (59.8%).

46 Subtype 1 (r = -0.201, P = 0.016) but not in Subtype 2 (r = -0.045, P = 0.652), potentially indicatin

47 tein-coupled receptor, somatostatin receptor subtype 2 (SSTR2), in pituitary cells.

48 Subtype 2 had normal and stable anatomy, except for larg

49 Subtype 2 showed increased volume in the basal ganglia a

50 the N-methyl-d-aspartate receptors (NMDARs) subtype 2B (GluN1/2B), we investigated in the current wo

51 with U46619 and prostaglandin E(2) receptor subtype 3 activated with iloprost showed a similar react

52 elationships are different in the two cancer subtypes; (3) key neural functions such as neural crest

53 Rats were orally infected with Blastocystis subtype 4 (ST4) cysts, isolated from human stool samples

54 as were restricted to the molecular SHHalpha subtype(4) and characterized by universal biallelic inac

55 P1 subtype 2 (P1-2) was the predominant P1 subtype (59.8%).

56 trains were subtype C (85% C3), and 33% were subtype A.

57 sting for age, gender, baseline BCVA and AMD subtype, A (protective) allele of C2-CFB-SKIV2L rs429608

58 The clustering revealed 2 distinct PCOS subtypes: a "reproductive" group (21%-23%), characterize

59 y associated miRNAs much improves the cancer subtyping accuracy.

60 f the study was the effect of primary tumour subtype, age, and sex and on severe acute respiratory sy

61 ide bond was essential for alpha3beta4 nAChR subtype allosteric selectivity.

62 s were used to assess associations of asthma subtype and AF.

63 redominantly of germinal center B-cell (GCB) subtype and carried gene mutations similar to the adult

64 ive and clinical stage, sex and histological subtype and is better than PDC without- MCR.

65 tial binding to the proinflammatory monocyte subtype and partially via SR-BI (scavenger receptor BI).

66 e tumor immune microenvironment that vary by subtype and pathologic response.

67 by a member of the largest ubiquitin ligase subtype and reveal how a defined architecture within a d

68 using a novel machine-learning tool called "Subtype and Stage Inference" (SuStaIn) and to evaluate t

69 eity and limited information about molecular subtypes and actionable biomarkers.

70 sociated cytokine changes differed among CRS subtypes and control tissues.

71 Our identification of discrete cell subtypes and differentially expressed genes within the h

72 inferences, drug resistant mutations (DRMs), subtypes and HIV-1 diversity estimations were completed.

73 9 inhibited promoter activity of diverse HIV-subtypes and HIV-1 replication in primary T cells.

74 n strategy enabling assaying of individual C-subtypes and impurities for ototoxicity and antimicrobia

75 creased in breast cancer of luminal and HER2 subtypes and inversely correlated with patients' prognos

76 MLVA type was associated with P1 subtypes and P1-2 variant types but not with macrolide r

77 s; however, the genetically-defined neuronal subtypes and projections that govern these behaviors are

78 s that were associated with distinct MDS/MPN subtypes and that were mutually exclusive with most of t

79 own about the molecular make-up of human EEC subtypes and the regulated secretion of individual hormo

80 ng issues regarding the origins of molecular subtypes and their progression relationships.

81 g that LVI and perineural invasion, mucinous subtype, and low age constitute independent risk factors

82 rt, VTE risk associated with incident HF, HF subtypes, and abnormal echocardiographic measures in the

83 ion and the signaling mechanisms of receptor subtypes, and the dynamics of ACh hydrolysis.

84 in differential association of GlycA with HF subtypes, and whether therapeutic lowering of GlycA can

85 ctions is a key feature in cancer diagnosis, subtyping, and treatment, where it complements routine h

86 The phenotypes of each breast cancer subtype are defined by their transcriptomes.

87 genic avian influenza viruses of the A(H5N1) subtype are endemic and cocirculate with other influenza

88 Our results suggest that these subtypes are biologically relevant because they appear t

89 en coupled with cas gene systems, CRISPR-Cas subtypes are highly site and taxon specific.

90 disorder, but diagnoses and determination of subtypes are made based on symptoms.

91 tients, including those with SPINK1-positive subtype, are treated with AR-antagonists.

92 ences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of

93 t 22% of tumors exhibited a novel epigenomic subtype associated with hypermethylation and somatic mut

94 i that were associated with the reproductive subtype at genome-wide significance (PRDM2/KAZN, P = 2.2

95 odies against 3 different hemagglutinin (HA) subtypes, at low prevalence, while carnivores showed a h

96 ch is to identify neurobiologically informed subtypes based on brain imaging data.

97 o resistance to stem bnAbs is low for the H3 subtype but substantially higher for the H1 subtype owin

98 We found that 51% of KSHV-strains were subtype C (85% C3), and 33% were subtype A.

99 8) alone at months 0 and 1 and with bivalent subtype C gp120/MF59 at months 3, 6, and 12.

100 human T-cell leukaemia virus type 1 (HTLV-1) subtype c is endemic to central Australia.

101 In this study, a 12-month booster of subtype C pox-protein vaccines restored immune responses

102 s retaining exceptional potency against some subtype C viruses.

103 Our results also demonstrate that glycan subtype can be predicted at some glycosites based on seq

104 (n = 928), we investigated whether molecular subtypes can be robustly identified using methods potent

105 -pathogenicity avian influenza virus (LPAIV) subtypes can reassort with circulating human strains and

106 Two informatics approaches (subtype categorization to define phylogenetic clusters a

107 These subtypes challenge the notion that brain volume loss is

108 eal the tumor signal perturbation status and subtype classification.

109 ur biologically distinct consensus molecular subtypes (CMS1-4) using gene expression.

110 cape of 34 BI-ALCLs (15 tumor and 19 in situ subtypes) collected from 54 BI-ALCL patients diagnosed t

111 nveyed the greatest relative risk for all PC subtypes combined (RR, 2.30; 95% CI, 2.22 to 2.40), foll

112 ification includes 2 classes, 6 types and 33 subtypes, compared with 5 types and 16 subtypes in 2015.

113 However, organoid stress and subtype defects are alleviated by transplantation into t

114 positively correlated with survival in a GBM subtype defined by low expression of ASCL1, a proneural

115 ific molecular mechanism that underlies PDAC subtype definition.

116 i sarcoma (KS)-associated herpesvirus (KSHV) subtype depends mostly on patient origin.

117 ians that refines cortical projection neuron subtype development.

118 Histopathologic subtype, differentiation grade, lymphovascular invasion,

119 nt-derived xenografts with species-conserved subtype-discriminating functional properties.

120 We found that C-subtypes displayed broad and potent in vitro antimicrobi

121 N = 36,360) were classified into one or more subtypes: early onset (EO), lethal, and/or clinically si

122 nical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) w

123 -cell lymphoma-let alone any of the specific subtypes, except advances made for patients with CD30-po

124 All GTT subtypes express programmed death-ligand 1 (PD-L1), and

125 lly-mediated role of CRC consensus molecular subtype features with the potential to inform precision

126 ompt the dismissal of discrete transcriptome subtypes for HGSOC and replacement by a more realistic m

127 cell proliferation in vitro, a hallmark cell subtype found in the pathology of index cases.Conclusion

128 Here we report switching of fibroblast subtypes from a neonatal to adult state and this drives

129 criptomic changes occur in distinct neuronal subtypes from several families of principal neurons (L5-

130 ndemic influenza outbreaks of 1918 and 2009, subtype H1N1 influenza A viruses (IAVs) have caused seas

131 iruses has led to the emergence of new virus subtypes (H5Nx), notably H5N2, H5N6, and H5N8.

132 Genetic analyses showed that all subtypes had an excess of genetic risk for Alzheimer's d

133 Exacerbation-prone asthma subtype has been reported in studies using data-driven m

134 undamental differences between breast cancer subtypes has driven therapeutic advances; however, basal

135 Diverse applications-particularly in tumour subtyping-have demonstrated the importance of integrativ

136 ciation of GlycA with the heart failure (HF) subtypes: heart failure with preserved ejection fraction

137 iltrating lymphocytes (continuous variable), subtype (HER2-enriched and basal-like vs rest), and 13 g

138 ging to one of the following five histologic subtypes: high-grade myxoid liposarcoma (HG-MLPS); leiom

139 eceptive fields of these two mechanoreceptor subtypes homotypically tile glabrous skin in a manner th

140 F-FDG PET/CT had high specificity for all IE subtypes; however, sensitivity was markedly lower for na

141 e classification of melanoma into four major subtypes (i.e., BRAF-mutant, NRAS-mutant, NF1-deficient,

142 r potency for the alpha3beta2 neuronal nAChR subtype (IC(50) 1.3 nM).

143 te that our method achieves high accuracy in subtype identification.

144 ures reported for each gene-specific disease subtype in the literature and highlight the importance o

145 ries (NCCL), of which 179 were sequenced and subtyped in the gag, protease (PR)-reverse transcriptase

146 nd 33 subtypes, compared with 5 types and 16 subtypes in 2015.

147 ssociation of GlycA with incident HF and its subtypes in a multiethnic cohort.

148 dentified and characterized a variety of RGC subtypes in animal models, although only a handful of st

149 completely distinct morphologically defined subtypes in humans.

150 Selective ablation of any of these subtypes in mice did not induce gastroparesis per se, no

151 he identification of both good and poor risk subtypes in patients treated with R-CHOP (rituximab, cyc

152 monstrate the differential loss of these RGC subtypes in response to disease or injury.

153 ation of L-type current among the major VGCC subtypes in SCN neurons, but also reveal that diurnal mo

154 cy range, the role of distinct interneuronal subtypes in slow (<60 Hz) and fast gamma states remains

155 By extending our analyses to other melanoma subtypes in The Cancer Genome Atlas, we predict that ele

156 We identified three neurocognitive subtypes in the depressed group.

157 phil populations containing Nalpha and Nbeta subtypes in the ear dLN.

158 rneurons (Gad1+), as well as Sst+ and Pvalb+ subtypes in the mPFC produced dose and time-dependent an

159 derstanding the relative contributions of HC subtypes in the outer retina.

160 show that neurochemically distinct neuronal subtypes in the primary auditory cortex have different c

161 interneurons (Sst and Pvalb), whereas other subtypes in the same families were less affected.

162 e the importance of assessing histologic CRC subtypes independently.

163 f using CC mice for studying complex disease subtypes influenced by sex and genetic background.

164 Our main discoveries are: (1) while both subtypes involve neural functions, TNBC has substantiall

165 alignant mesotheliomas (MM), the sarcomatoid subtype is associated with higher chemoresistance and wo

166 The human FBN1+ FAP cell subtype is novel and a corresponding FBN1+ FAP cell type

167 and host factors suggests the acral melanoma subtype is uniquely unrelated to pigmentation.

168 owever, integrated molecular knowledge of EN subtypes is lacking.

169 n or malignant, and if it is malignant, what subtype it belong to, and whether it should be managed w

170 significantly associated with the metabolic subtype (KCNH7/FIGN, P = 1.0 x 10-8).

171 Fibroblast subtypes localize to discrete anatomical positions offer

172 Physiologically, one of the VTA Sst neuron subtypes locally inhibited neighboring dopamine neurons.

173 In multiple lymphoma subtypes, malignant B cells hijack AgR signaling pathway

174 In kidney cancer, RP subtypes map to molecular subtypes related to cell-of-or

175 TMN2 RNA was confined to tissues and disease subtypes marked by TDP-43 inclusions.

176 man and mouse data sets identified shared EN subtype markers, which were visualized in situ using hyb

177 gest that targeted perioperative care for HF subtypes may be crucial for the growing population of HF

178 While the NAc expresses various HA receptor subtypes, mechanisms by which HA modulates NAc circuit d

179 n tumor development as governed by molecular subtype mutations and lineage-restricted differentiation

180 ficant associations with molecular subgroups/subtypes, mutations, and prognosis.

181 In the United States, NAFLD and its subtype, nonalcoholic steatohepatitis, affect 30% and 5%

182 In this subtype of AML, the translocation of a GATA2 enhancer (3

183 ol brains to identify a convergent molecular subtype of ASD with shared dysregulation across both the

184 disease (AERD) is a mechanistically distinct subtype of chronic rhinosinusitis with nasal polyps (CRS

185 urposeful biologic regulation to create this subtype of circadian rhythms.

186 his effect of leptin is mediated by the NMDA subtype of glutamate receptors (NMDARs).

187 d "macrotrabecular-massive" (MTM) histologic subtype of hepatocellular carcinoma (HCC) (MTM-HCC) repr

188 TAFRO syndrome, a clinical subtype of idiopathic multicentric Castleman disease (iM

189 cancer (NSCLC), the most common histological subtype of lung cancer.

190 entify transcription factors that define one subtype of neural crest, the cardiac crest, and demonstr

191 enoma and early adenocarcinoma, a pathologic subtype of non-small cell lung cancer.

192 lication stress was enriched in the squamous subtype of PC (P < .001) but was not associated with DDR

193 nt clinical questions are whether there is a subtype of schizophrenia which responds differently to c

194 Only the pSCC subtype of tongue cancer was associated with nociceptive

195 e DNA/RNA-binding protein FUS causes certain subtypes of ALS/FTD by largely unknown mechanisms.

196 cohort of 404 patients comprising different subtypes of B cell neoplasms, we demonstrate that IgCall

197 e provide a tool for assessment of molecular subtypes of bladder cancer in routine clinical practice.

198 ay utilization distinguish EMT and papillary subtypes of breast cancer and identify said pathways as

199 s associated with worse prognosis than other subtypes of breast cancer.

200 Up to four different subtypes of C. acnes were observed in the deep tissues o

201 Of 11 patients, 5 (45%) had different subtypes of C. acnes within the deep tissues even though

202 mber variations (CNV), associated with novel subtypes of childhood B-ALL, have prognostic significanc

203 arcinoma (CRC) cells typifying all molecular subtypes of CRC.

204 s of ALDH+/CD133+ and drug-resistant (MDR1+) subtypes of CSCs with specific metabolic and stemness si

205 and whether such transition affects risks of subtypes of CVD in Chinese adults.

206 e the differentiation of serotonergic neuron subtypes of DR.

207 We are thus able to alter the subtypes of drugged lymph node cells to improve immunoth

208 Genetic subtypes of dystonia may respond differentially to deep

209 ol individuals, independent of symptom-based subtypes of IBS.

210 ing and community detection, aim to identify subtypes of individuals within a class of symptoms or br

211 We identified 2 subtypes of internalizing youths differentiated by abnor

212 in cancer and shows activating mutations in subtypes of lymphoma.

213 Analyzing subtypes of major depressive disorder and bipolar disord

214 ing early preeclampsia and indicate distinct subtypes of pathophysiology and clinical morbidity.

215 gression challenging.Objectives: To identify subtypes of patients with COPD with distinct longitudina

216 COPD Genetic Epidemiology) study to identify subtypes of patients with COPD.

217 he identification of two clinically relevant subtypes of post-traumatic stress disorder (PTSD) and ma

218 feature that can occur in most histological subtypes of renal cell carcinomas (RCCs) and carries a d

219 s the dorsal raphe, which contains different subtypes of serotonergic neurons.

220 alth status and its transition with risks of subtypes of vascular disease across body mass index (BMI

221 Daraszkiewicz proposed a soft subtyping of hebephrenia based on level of deterioration

222 CARMEN-Cas13 further enables comprehensive subtyping of influenza A strains and multiplexed identif

223 ons were found for the microsatellite stable subtype or late stage colorectal cancer.

224 lic MDD, and did not generalize to other MDD subtypes or other psychiatric disorders.

225 oorly differentiated or grade 3 histological subtype, or any FIGO (1988) stage IIB-IV epithelial canc

226 subtype but substantially higher for the H1 subtype owing to structural differences in the HA stem.

227 However, SadP adhesin from systemic subtype P(N) strains also binds to globotetraosylceramid

228 A multivariable model including the ALL subtype (P = 1.1 x 10-14), the SLC19A1/(ABCC1 + ABCC4) t

229 no effect measure modification by molecular subtypes (P for interaction = 0.889).

230 with the identification of several clinical subtypes, pathogenic genes and putative causative enviro

231 eir predicted functions with tumor types and subtypes, patients' smoking status, and the response to

232 The PDE4 family comprises four subtypes, PDE4A, B, C, and D.

233 ns of skeletal muscle cells using RNA-seq of subtype-pooled single human muscle fibers and single cel

234 1 DR neurons - the most molecularly distinct subtype - possess unique efferent projections and electr

235 hese analyses by colorectal cancer molecular subtypes potentially explain the inconsistent findings b

236 ost studies recruited a single symptom-based subtype rather than all presentations of FND.

237 tion protocols generate heterogeneous neural subtypes rather than a specific neuronal population.

238 tively investigated the associations of PUFA subtypes, ratios, and fish with the incidence of head an

239 In all cases, Galgo subtypes reflected enrichment of gene sets related to th

240 kidney cancer, RP subtypes map to molecular subtypes related to cell-of-origin.

241 unctional diversity of nucleases within each subtype remains poorly explored.

242 ed neurotrophic factor NGF leads to aberrant subtype-restricted patterns of transcription factor expr

243 ssNPA is a new approach for subtyping samples based on deregulation of their gene ne

244 structure of M(1)AChR in complex with MT7, a subtype-selective anti-M(1)AChR snake venom toxin.

245 summarize the current state of the field of subtype-selective GABA(A)R modulators acting via the BZD

246 n of the pharmacology of BZDs indicates that subtype-selective GABA(A)R modulators will have novel ph

247 structure-based drug design to develop more subtype-selective GPCR ligands with potentially reduced

248 Subtype-selective OX1R antagonists are valuable tools to

249 t in RORgammat suggests a high potential for subtype-selective targeting of this NR to more effective

250 e (NAcore) contains two predominate neuronal subtypes selectively expressing either D1-dopamine or D2

251 nverse agonists displaying high affinity and subtype selectivity over the antitarget M(2) are valuabl

252 s with high potency and excellent JAK family subtype selectivity.

253 While some dSTACs elicit ER subtype-selectivity in the presence of hormone, most syn

254 The SOCS1/SGK1 subtype showed biological overlap with primary mediastin

255 and white matter integrity, with one of the subtypes showing poorer functioning across multiple doma

256 rs to refine the differentiation of neuronal subtypes.SIGNIFICANCE STATEMENT Predisposition to anxiet

257 ncrease in TFA level and assessed histologic subtype-specific associations with multivariable polytom

258 identify said pathways as a means to enhance subtype-specific diagnoses and treatment strategies.

259 However, some EN subtype-specific genes from mice are expressed in comple

260 This study describes the use of a subtype-specific Kv7 activator to assess assembly of het

261 inct molecular subgroups, with potential for subtype-specific precision therapy.

262 7ac histone modification, we identify neuron-subtype-specific regulatory elements that previously wen

263 on in the brain, raising the possibility for subtype-specific targeting by pharmacological means for

264 shing transcription factor within islet cell subtype specification.

265 mposed of annotations of the five hemorrhage subtypes (subarachnoid, intraventricular, subdural, epid

266 Additionally, we quantified cost changes by subtype, such as costs due to increased healthcare utili

267 ecular differences and species-specific cell subtypes suggesting possible evolutionary divergence.

268 l lung cancer (NSCLC) is a major lung cancer subtype that leads to many cancer-related deaths worldwi

269 s emerging: the classification of TIMCs into subtypes that are conserved across patients and across s

270 unctions among the genetically diverse viral subtypes that contribute to the HIV-1 pandemic.

271 uscles are innervated by two mechanoreceptor subtypes that exhibit distinct responses to tactile stim

272 In mice, we identified several neuronal subtypes that stably express gene modules across all int

273 s, along with clinical data, we identified 4 subtypes that were associated with patient outcomes and

274 population of neurons, comprised of numerous subtypes that work synchronously to transmit visual info

275 roved to be effective in a variety of cancer subtypes, the role of immune checkpoint inhibition in th

276 Among tumor molecular subtypes, the strongest inverse association was observed

277 sifier to identify medulloblastoma molecular subtypes through the use of transcriptomic profiling dat

278 sk of medically attended infection with that subtype throughout life.

279 nd that sequence analysis can predict glycan subtype, thus predicting the presence or absence of this

280 the potential for connecting circuit-defined subtypes to more distal features derived from digital ph

281 s disease mechanisms (rather than malignancy subtypes) to provide a comprehensive description of key

282 ls, two triple-negative breast cancer (TNBC) subtypes, to demonstrate that ZEB1 represses POLQ expres

283 ity of lung cancers as well as incidences of subtype transdifferentiation raise the question of to wh

284 GBM can be subcategorized into four distinct subtypes; tumors that shift towards the mesenchymal phen

285 cedures for the antemortem diagnosis of sCJD subtype using diffusion magnetic resonance imaging (MRI)

286 The worst-prognosis subtype was characterized by mesenchymal gene signatures

287 The clinical PCWG3 subtype was determined for PET versus CI by 3 masked rea

288 Furthermore, these subtypes were associated with novel, to our knowledge, s

289 Subtypes were evaluated for differences in both clinical

290 The most frequent lymphoma subtypes were extranodal marginal zone B-cell lymphoma (

291 Subtypes were patients with high meibum delivery (hypers

292 tical GABAergic neurons that contain diverse subtypes, which participate in layer-specific cortical c

293 ic alpha7- and heteromeric alpha7beta2-nAChR subtypes while preferentially enhancing alpha7beta2-nACh

294 Fecal bacterial profile differed between IBS subtypes, while the mucosa-associated bacterial profile

295 en computationally classified into molecular subtypes whose functional relevance remains to be compre

296 Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-

297 prove stratification of cancer patients into subtypes with distinct survival and therapy response pro

298 We leveraged the presence of clinical subtypes with each disease cohort to identify miRNAs tha

299 d (compared with nonuse) and risk of several subtypes, with effects that appeared strongest for TNBC

300 ctive and previously unrecognized myonuclear subtypes within dystrophic myofibers and uncover degener