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1 bunits) and methyltransferase (HsdM and HsdS subunits).
2 ribosomal RNA (rRNA) of the large ribosomal subunit.
3 ifferent genes and CAPZA2 encodes the alpha2 subunit.
4 ia a SUMO-interacting motif in the HDAC Cpr1 subunit.
5 noglobulin G (IgG) class and targeted the S2 subunit.
6 y a single phosphorylation site on the GluA2 subunit.
7 oribosomes and the maturation of their small subunit.
8 gineered into receptors containing the delta subunit.
9 a large (TerL) and a small (TerS) terminase subunit.
10 suggesting an interaction with this protein subunit.
11 om the N-terminal segment of the neighboring subunit.
12 and prevents its association with the small subunit.
13 ncert with components of the large ribosomal subunit.
14 genes of either the small or large ribosomal subunit.
15 he conserved N terminus of the Rubisco large subunit.
16 ur data showing mislocalization of the gamma subunit.
17 washer" conformation and dock onto the STAG1 subunit.
18 ma as a tetramer of two A-subunits and two B-subunits.
19 ich selectively removes and degrades damaged subunits.
20 tion that generated distinct alpha- and beta-subunits.
21 al gating cooperativity between Nav1.5 alpha-subunits.
22 e smallest and the least conserved among ORC subunits.
23 that accepts the two mitochondrially encoded subunits.
24 s for 30 proteins, including 23 radial-spoke subunits.
25 lpha-subunit and one or more associated beta-subunits.
26 ion proteins, including three RNA polymerase subunits.
27 omplex formation, and the degradation of its subunits.
28 en assembled from multiple simpler identical subunits.
29 AMPARs that contain fast desensitizing flop subunits.
30 rest-neighbor distances between Nav1.5 alpha-subunits.
31 erotetramer comprising two GyrA and two GyrB subunits.
32 ributed to cytochrome c (1) being one of its subunits.
33 , depending on the presence of distinct beta-subunits.
34 n synthesis by immature Escherichia coli 30S subunits.
35 ng of the properties of its light-responsive subunits.
36 stem that allows ectopic targeting of Ctf19c-subunits.
37 f eukaryotic translation initiation factor 2 subunit 1 (eIF2alpha), the SG assembly G3BP paralogs, or
38 cluding core-binding factor alpha1, mediator subunit 12, transcriptional coactivator CBP and TATA-box
39 ariants in protein phosphatase 1, regulatory subunit 12a (PPP1R12A), an important developmental gene
41 ransferase general transcription factor IIIC subunit 4 and decreased histone deacetylase 5 expression
44 broblasts showed reduced levels of the AP4E1 subunit, a surrogate for levels of the AP-4 complex.
45 isomeric, yet, different, 8pai antiaromatic subunits, a benzocyclobutadiene (BCB) and a pentalene, a
46 e with four Zn(2+) binding sites within each subunit: a highly conserved primary site in transmembran
47 d pathway regulating interleukin-27 receptor subunit alpha (IL-27Ra) expression on hematopoietic stem
50 mination microscopy that knockdown of the a3-subunit altered the diameter and density of individual C
51 reased expression of the IL-2 receptor alpha-subunit and activation of the transcriptional regulator
55 nds to uL14 protein onto the large ribosomal subunit and prevents its association with the small subu
57 on, scaffolds the L-type pore-forming alpha1 subunit and, through its C-terminal region, scaffolds th
59 quired for the stability of the EARP complex subunits and for the localization of EARP and its associ
60 m, we engineered an HA tag onto Cx26 or Cx30 subunits and imaged hemichannels that were liganded by F
62 ing either alpha1, alpha2, alpha3, or alpha5 subunits and the molecular dissection of the pharmacolog
67 t of a DNA endonuclease (HsdR, HsdM and HsdS subunits) and methyltransferase (HsdM and HsdS subunits)
68 ion involving the regulatory domain of sigma subunit, and potentially pinpoint a novel target for dev
69 s by varying calcium permeability, auxiliary subunits, and activation levels and show that Zn(2+) inh
70 the carboxy-terminal domains of both of its subunits, and this inhibition is released by interaction
72 f-assembling nanoparticles, including the 60-subunit Aquifex aeolicus lumazine synthase (LuS) and the
73 classes, revealing how contacts to the small subunit are maintained throughout intersubunit rotation.
74 rrelates with nucleotide occupancy: five MCM subunits are bound to either ATPgammaS or ADP, whereas t
76 ontacts between the penultimate and terminal subunits are consistent with existing cryogenic electron
78 he quinone-binding site to the transmembrane subunits are found to be responsible for proton pumping.
81 e cytosolic portions of beta- and gamma-ENaC subunits as being important for PIP(2)-ENaC interactions
82 eric receptors that contain binding-impaired subunits, as we show for both kainate and GluA2 AMPA rec
83 Although much is known about the auxiliary subunits associated with postsynaptic GluRs, far less is
85 intersubunit bridges to the small ribosomal subunit, assumes different conformations in the five cla
86 almodulin, the distance across the two GluN1 subunits at the entrance of the first transmembrane segm
87 tly tagged retrograde tracers (cholera toxin subunit B) into retinotopically-matched locations in var
88 of these molecules to pop out of this second subunit before finally re-entering to form a stable comp
89 ts, we investigated the effects of G protein subunit beta 5 (Gnb5) knockout on insulin secretion.
90 itor of interleukin-23 (IL-23) via IL-23 p19 subunit binding, significantly improved psoriatic arthri
92 EM) structures of DNA-PKcs (DNA-PK catalytic subunit) bound to a DNA end or complexed with Ku70/80 an
94 d, oxidized, and depleted of its stabilizing subunit calstabin-1 6 hours after the onset of the mecha
95 subtilis gyrase is a minimal enzyme, and its subunits can functionally interact with subunits from ot
96 es can self-assemble from smaller individual subunits, can be produced from prokaryotic and human exp
97 n mutants; the heterodimeric capping protein subunit CAPZB and its partner TWF2 never concentrated at
98 d silencing, we identified that the GABA(A)R subunit combination alpha3beta2gamma1 conforms the bulk
99 in-containing TCP-1 (CCT or TRiC) is a multi-subunit complex that folds many of the proteins essentia
100 stinct cellular functions, but how the multi-subunit complexes influence deacetylase activities and s
101 kinase module (CKM) is a detachable Mediator subunit composed of cyclin C and one each of paralogs Cd
102 e further investigated mTOR complex-specific subunit composition and phosphorylation state, and found
105 ster is only moderately selective for alpha5-subunit-containing GABA(A) receptors, the derivative SH5
106 s of brain injury, drugs that inhibit alpha5 subunit-containing gamma-aminobutyric acid type A recept
107 Thus, we postulated that inhibiting alpha5 subunit-containing gamma-aminobutyric acid type A recept
110 f Kir6.1 (Kir6.1(-/-) ) or SUR2 (SUR2[STOP]) subunits, contractile parameters were not significantly
116 OSCP and F(6) The final component of the PS, subunit d, is added subsequently to form a key intermedi
117 IFT54 directly interacted with IFT dynein subunit D1bLIC, and deletion of residues 261-275 reduced
118 controlled Pol II kinetics by coupling rapid subunit degradation with orthogonal experimental readout
121 complexes form a core to which the catalytic subunit dimers are attached, adopting the shape of a Mal
123 of dystonia, although variants in different subunits display different phenotypic and inheritance ch
126 s a powerful tool for obtaining insight into subunit diversity, post-translational modifications, sto
127 identify inhibitors of the DNA-PK catalytic subunit (DNA-PKcs) with good selectivity versus the stru
129 nd higher-order changes induced by the beta3-subunit do not alter the degree of electrophysiological
131 rising from the inactivation of the N-module subunits due to attrition caused by its constant activit
132 atekeepers MICU1 and MICU2, and an auxiliary subunit, EMRE, essential for Ca(2+) transport(3-8).
133 cetylcholine receptors containing the alpha5 subunit encoded by Chrna5 Disruption of this gene impair
135 tes, and deletion of the only G-protein beta-subunit-encoding gene of A. oligospora nearly abolished
136 e complex 2 (PRC2) is composed of three core subunits, enhancer of zeste 2 (EZH2), embryonic ectoderm
137 es the ratio of ATP synthase enzyme to its c-subunit, enhancing ATP production efficiency and synapti
140 out of both AMPK catalytic alpha1 and alpha2 subunits exhibited significantly higher fasting blood gl
141 erotrimeric complex, and its catalytic alpha subunit exists in 2 isoforms: AMPKalpha1 and AMPKalpha2.
144 of a large subunit (LiGPPS.LSU) and a small subunit for which two different cDNAs (LiGPPS.SSU1 and L
145 ere also fast, but absolutely required Kv3.3 subunits for fast repolarization (half-widths: 0.25 +/-
147 of major capsid proteins and terminase large subunits further suggests they form a distinct clade wit
149 t non-coding gap in a phage T4 topoisomerase subunit gene (gp60) requires several recoding signals.
150 whole brain and regional signatures of AMPAR subunit gene expression in healthy human brains as well
151 ha3 nicotinic acetylcholine receptor (nAChR) subunit gene, increases risk of tobacco dependence but u
152 on under redox control include NMDA receptor subunits GluN1 and GluN2A as well as KEAP1 (regulator of
153 tes phosphorylation of NMDA receptor (NMDAR) subunit GluN2B and that GluN2B-containing NMDARs also re
154 pecific knockdown or deletion of a key NMDAR subunit, GluN2B, implicated in the actions of ketamine.
156 ndothelium-specific expression of Kir6.1 GoF subunits had negligible effects on lymphatic contraction
157 new azacryptand containing three azobenzene subunits has been developed, and its photoisomerization
160 ng measurements performed on cholera toxin B subunit homopentamer (CTB(5)) and nanodiscs containing a
162 a receptor bearing multiple light-switchable subunits in a confined space is critical for the design
163 ) mapping of the static positions of SBF/MBF subunits in fixed cells revealed each transcription fact
164 ntegrator, but the roles of other Integrator subunits in gene regulation have yet to be elucidated.
166 rotein abundance of specific nuclear-encoded subunits in oxidative phosphorylation complexes I and V
169 tact V-ATPase from bovine brain with all the subunits including the subunit H, which is essential for
170 atin regulatory regions of the NADPH oxidase subunits increases in the mdx muscle and JQ1 administrat
175 al vector-induced re-expression of the beta4 subunit into either the MHb or IPN restored a "stop" sig
178 antitative analysis indicates that the beta3-subunit is not required for this clustering but beta3 do
180 erences in the interactions of the catalytic subunit Isw1 with the acidic pocket of nucleosomes and t
181 esidues, and ultimately serves to coordinate subunit joining through the release of late-stage mtLSU
184 onditional kidney tubule-specific ENaC gamma-subunit knockout mice displayed decreased claudin-8 expr
186 s heteromeric protein, consisting of a large subunit (LiGPPS.LSU) and a small subunit for which two d
189 ort that ablation of m(6)A methyltransferase subunit METTL14 in myeloid cells exacerbates macrophage
190 mitochondrial localization of the core MICOS subunit Mic60 in relation to two other MICOS proteins, M
191 ith the alpha-carboxyltransferase (alpha-CT) subunit of ACCase and participate in an original mechani
194 opsis thaliana mutant of the POL2A catalytic subunit of DNA polymerase epsilon and show that POL2A is
196 on requires RNA cleavage by the endonuclease subunit of Integrator, but the roles of other Integrator
199 r of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2), which s
200 aration-of-function mutations into the SUZ12 subunit of PRC2 to drive it into a PRC2.1 or 2.2 subcomp
202 mice with a genetic deletion of the specific subunit of system x(c)(-), xCT (xCT(-/-) mice), we uncov
203 nactivation of the gene SMARCB1, a conserved subunit of the chromatin remodeling BAF complex, which h
205 ection of inhibitory antibodies to the alpha subunit of the Gs heterodimeric protein (GalphaS) into w
206 on genetic ablation of METTL3 (the catalytic subunit of the major m(6)A methyltransferase complex), m
207 alently modify cysteine-54 (C54) of the MPC2 subunit of the mitochondrial pyruvate carrier (MPC) is p
208 his study, we examine the role of the NCKAP1 subunit of the pentameric cytoskeletal SCAR/WAVE complex
210 tracellular HA-DAT colocalized with VPS35, a subunit of the retromer complex mediating recycling from
219 ulating effect, i.e. they can bind to Galpha subunits of different classes and either stimulate or in
220 ilencing of endogenous genes that encode two subunits of magnesium chelatase, an enzyme necessary for
223 ss-of-function variants in genes that encode subunits of the adaptor protein complex 4 (AP-4) lead to
229 impact of loss-of-function variants in AP-4 subunits on intracellular protein trafficking using pati
230 interaction modes are modulated by accessory subunits, oncogenic histone mutations, and the methylati
231 n about turn in order to enter a neighboring subunit, only for some of these molecules to pop out of
232 hase leak channel by mild depletion of its c-subunit or pharmacological inhibition normalizes stimulu
234 s bound to the preformed F(1)-c(8) module by subunits OSCP and F(6) The final component of the PS, su
236 d an 11% decrease of AMY levels of the GluA1 subunit (p = 0.05) and a 21.5% decrease of aHIP levels o
238 ) retains binding to an NADPH oxidase (NOX2) subunit, p67(phox), and to the RAC-binding domain of p21
239 xis toward host serum, and these ion channel subunits partially rescue sensory defects in Caenorhabdi
241 A receptor (AMPAR) and NMDA receptor (NMDAR) subunit phosphorylation that likely contribute to increa
243 2A-dependent dephosphorylation of the alpha2 subunit play a role in the dynamic regulation of GABA(A)
244 monstrate that alpha2delta1 and alpha2delta3 subunits play distinct but complementary roles in drivin
246 contrast, later in development, alpha2delta1 subunits promote the glutamatergic neurotransmission and
248 ule-specific expression of an L10a ribosomal subunit protein fused with enhanced green fluorescent pr
249 that conditional loss of a Mediator complex subunit protein, Med23 in mouse neural crest cells (Med2
250 loroplast and nuclear genes encoding the PSI subunits (psaA, psaB, and PSAN), the PSII subunits (psbA
251 SI subunits (psaA, psaB, and PSAN), the PSII subunits (psbA, psbB, and PSBW), the antenna proteins (L
252 ), the ribulose 1.5-bisphosphate carboxylase subunits (rbcL and RbcS), and enzymes of chlorophyll bio
253 r antagonist with high selectivity for GluK1 subunits, reduces the desensitization of GluK1/GluK2 het
255 In this work, we examined Spo7, a regulatory subunit required for Nem1 catalytic function, to identif
257 eeping genes such as that encoding the small subunit ribosomal RNA has revealed the extensive diversi
259 plant toxin, ricin, is due to its enzymatic subunit, RTA, which inactivates mammalian ribosomes with
261 idal output neurons showed age-related nAChR subunit-selective reductions in postsynaptic responses t
262 reviously established that the Med1 Mediator subunit serves as a cofactor of GATA TFs in Drosophila,
265 roduced that lacked cognate Se Rubisco small subunits (SSU) and expressed the Se LSU in place of toba
266 c stabilization of the Plasmodium TRiC delta subunit, suggesting an interaction with this protein sub
268 re, we analyze the requirements for core CPC subunits, survivin and INCENP, and the mitotic kinesin-l
269 nd the cyclic nucleotide-gated (CNG) channel subunit tax-4 in larval chemotaxis toward host serum, an
271 p52Shc binding and activating the p47(phox) subunit that results in redox stress and accelerated fib
272 heterotetramer of paralogous alpha- and beta-subunits that mediates respiratory oxygen transport and
273 SERCA is regulated by small membrane protein subunits, the most well-known being phospholamban (PLN)
274 hromatin association of individual replisome subunits, thereby challenging the notion that lagging-st
275 that each TF interacts with a dedicated MED subunit to induce specific transcriptional responses.
278 ses, by stimulus-dependent ATP synthase beta subunit translation; this increases the ratio of ATP syn
279 f this variant in a member of the core TRAPP subunit, TRAPPC4 that associates with vesicular traffick
281 duced in mice lacking all 3 immunoproteasome subunits (triple-ip(-/-)) or lacking either the gene enc
283 on and structure of assembling 60S ribosomal subunits undergo numerous changes as pre-ribosomes trans
284 MF59-adjuvanted glycoprotein B (gB) protein subunit vaccine (gB/MF59) is the most efficacious vaccin
285 ion would be the development of an effective subunit vaccine; however, no approved vaccine currently
286 Using this strategy, the fused pyrrolidine subunit was constructed with exceptionally high regio- a
289 e (PI3K) comprised of the p110beta catalytic subunit was recruited to the gB/EGFR complex despite p11
290 motif linked to the 1,2,5-oxadiazole 2-oxide subunit was synthesized, indicating the stability of pre
293 tions in the expression level of alpha2delta subunits were implicated in several syndromes and diseas
295 t also allows the minimal number of distinct subunits when designing artificial nucleic acid structur
296 uncovered differential binding of these NPC subunits, where Nup107 preferentially targets active gen
297 incoming monomers, and flatten the terminal subunit, which likely promotes ATP hydrolysis and rapid
298 ibosome via specific interaction of the Not5 subunit with the ribosomal E-site in Saccharomyces cerev
300 rough the interaction of distinct regulatory subunits with conserved catalytic subunits in holoenzyme