ライフサイエンスコーパス: subunit composition

1 dependent activation of AMPARs with distinct subunit composition.

2 ssion and their functionality depends on the subunit composition.

3 nAChR desensitization depends on subunit composition.

4 cal roles served by BK channels of different subunit composition.

5 pse model to precisely control the GABA(A)-R subunit composition.

6 vivo, p97 molecules can be heterogeneous in subunit composition.

7 cellular factors, and not changes in channel subunit composition.

8 glycine receptors (GlyRs) depend upon their subunit composition.

9 ation of distinct Kv channels based on their subunit composition.

10 tested whether Neto2 modulation varies with subunit composition.

11 onal properties determined by their specific subunit composition.

12 ignaling and shows remarkable selectivity of subunit composition.

13 PSD, and they show how this alters receptor subunit composition.

14 show that each complex has a conserved five-subunit composition.

15 ults in a decrease in the NR2A/NR2B ratio of subunit composition.

16 ions or N-methyl-d-aspartate (NMDA) receptor subunit composition.

17 ct the aforementioned difference in receptor subunit composition.

18 asticity determined by NMDA receptor, NR2A/B subunit composition.

19 find that these TARPs specify AMPA receptor subunit composition.

20 iation, post-translational modification, and subunit composition.

21 iates with a Set1-like HMT complex of unique subunit composition.

22 onotropic glutamate receptors via changes in subunit composition.

23 eceptor ion channels are determined by their subunit composition.

24 y in NMDAR signaling created by diversity in subunit composition.

25 c role for Mecp2 in the development of NMDAR subunit composition.

26 NaC channels are characterized by a trimeric subunit composition.

27 roperties that are strongly dependent on the subunit composition.

28 on is mediated by changes in NMDAR and AMPAR subunit composition.

29 ulation of the size of GLUR fields and their subunit composition.

30 d to schizophrenia, regulates synaptic NMDAR subunit composition.

31 tein class, and are flexible with respect to subunit composition.

32 , suggesting a modification of NMDA receptor subunit composition.

33 d be formed by cell type- or tissue-specific subunit composition.

34 AR number or function, including a switch in subunit composition.

35 is not known what controls their number and subunit composition.

36 ely resulting from changes in GABAA receptor subunit composition.

37 monstrating its reliance on GABA(A) receptor subunit composition.

38 ate-gated ion channel receptors with defined subunit composition.

39 el distribution by NRA-2 is dependent on the subunit composition.

40 mediated current, loss of Neto1 alters NMDAR subunit composition.

41 d to simplify data analysis and decipher the subunit compositions.

42 DHA on BK channels with different auxiliary subunit compositions.

43 ning ion series to peaks and deciphering the subunit compositions.

44 may contain AMPA receptors (-Rs) with unique subunit compositions.

45 ticogeniculate synapses have distinct AMPA-R subunit compositions.

46 into nicotinic receptor pentamers of various subunit compositions.

47 ide variety of sizes, shapes, symmetries and subunit compositions.

48 hat hECN GABAARs have an alpha2/3beta3gamma2 subunit composition - a composition that also predominat

49 y-induced synaptic scaling by regulating the subunit composition, abundance, and trafficking of GluA2

50 ing amyloid fibrils, and the initial protein subunits composition, advancing our understanding on the

51 he functional study of NMDARs with different subunit composition after activation by glycine/D-serine

52 llosteric, ligand-gated ion channel with the subunit composition alpha2betagammadelta.

53 h form three plasma oligomers with different subunit compositions (alpha7beta1, alpha7beta0, and alph

54 ays, sodium pumping structures, cofactor and subunit composition, among others.

55 mutations correlated with alterations in ETC subunit composition and activity in primary glioma-initi

56 f temporally diverse signals which stem from subunit composition and also from the inherent ability o

57 CMKII mice revealed changes in NMDA receptor subunit composition and altered NMDA-dependent synaptic

58 produce purified hemichannels of controlled subunit composition and apply it to the generation of he

59 ely related to eukaryotic RNAPII in terms of subunit composition and architecture, promoter elements

60 ptic AMPA receptors (AMPARs) depend on their subunit composition and association with transmembrane A

61 Subunit composition and binding of allosteric modulators

62 The subunit composition and Ca(2+) permeability of AMPA rece

63 that underlies transient alterations in the subunit composition and calcium permeability of synaptic

64 60b levels, a concomitant switch in BAF/Brg1 subunit composition and delayed myogenesis.

65 ed a decrease in relative synaptic NR2B/NR2A subunit composition and did not exhibit LTP.

66 zation to morphine altered hippocampal NMDAR subunit composition and enhanced the SK2 channel-mediate

67 in gamma-aminobutyric acid receptor (GABAAR) subunit composition and function, playing a crucial role

68 ticity occur via modulation of nAChR channel subunit composition and functional clustering.

69 in vivo as multiple subtypes that differ in subunit composition and functional properties.

70 to the eukaryotic V-ATPase but has a simpler subunit composition and functions in vivo to synthesize

71 GABAergic synapses, the relationship between subunit composition and IPSC decay is less clear.

72 shapes N-methyl-D-aspartate receptor (NMDAR) subunit composition and kinetics at excitatory synapses

73 s or remain highly localized, depending upon subunit composition and ligand.

74 lexes from detergent micelles, which reveals subunit composition and lipid binding.

75 as well as the details of the gammaCA domain subunit composition and membrane anchoring.

76 et genes, resulting in altered NMDA receptor subunit composition and other molecular adaptations.

77 e further investigated mTOR complex-specific subunit composition and phosphorylation state, and found

78 properties and function are regulated by its subunit composition and phosphorylation.

79 mplex, an important step is to elucidate its subunit composition and posttranslational modifications.

80 Determination of the subunit composition and previous mutational analysis all

81 a developmental shift in glutamate receptor subunit composition and regulation of glutamatergic syna

82 on in large amount, followed by deduction of subunit composition and stoichiometry and determination

83 We determined the exact subunit composition and stoichiometry for the intact cor

84 The subunit composition and stoichiometry of these membrane

85 nopus oocytes to obtain receptors of defined subunit composition and stoichiometry.

86 oncatenated tetrameric channels with defined subunit composition and stoichiometry.

87 The subunit composition and subcellular distribution of AMPA

88 Here we report an analysis of the subunit composition and substrate specificity of the NSL

89 We investigated subunit composition and subunit-specific interactions in

90 tion of synaptic AMPARs by controlling their subunit composition and susceptibility to LTD.

91 PICK1 loss of function alters the subunit composition and the abundance of GluA2-containin

92 ium permeability depends critically on their subunit composition and the identity of associated auxil

93 heir properties are determined both by their subunit composition and their association with auxiliary

94 Receptor properties depend on NR2 subunit composition and variable splicing of NR1.

95 s population, these receptors are diverse in subunit composition and vary in subunit stoichiometry.

96 DPA antagonism was independent of NMDAR subunit composition and was similar at extrasynaptic and

97 y, consist of several subtypes with distinct subunit compositions and functional properties.

98 In addition, the subunit compositions and stoichiometries of the remainin

99 ctional alpha6beta2beta3* AChRs with defined subunit compositions and subunit orders.

100 , negative regulators, NF-kappaB binding and subunit composition, and MAPKs; conversely, IL-13(-/-) m

101 The number of FCP complexes, their subunit composition, and their interactions in the thyla

102 ype studied, their respective GABAA receptor subunit compositions, and critically, on the ambient GAB

103 NMDA/AMPAreceptor ratio and theAMPAreceptor subunit composition are altered in experimental parkinso

104 dual neurons, kainate receptors of different subunit compositions are targeted to various locations w

105 e-gated Ca(2+) channel function or different subunit composition as possible mechanisms underlying th

106 Purified mutant complexes have the same subunit composition as that of the wild-type complex, bu

107 tion of Ca(2+) channel function or different subunit composition as the underlying mechanism.

108 of gamma-secretase complexes, based on their subunit composition, as a valid strategy.

109 ian cells respond to hypoxia by altering COX subunit composition, as previously observed in yeast, bu

110 ic transmission and changes in AMPA receptor subunit composition at 72 h postsurgery.

111 t the acute activity-dependent switch in NR2 subunit composition at developing hippocampal synapses r

112 ecrease the NR2A/NR2B ratio of NMDA receptor subunit composition at glutamatergic synapses, a rejuven

113 In contrast, NMDARs subunit composition at mPP-DG synapses is not altered an

114 findings suggest that AIDA-1 regulates NMDAR subunit composition at synapses by facilitating transpor

115 ity of the coagonist not only with the GluN2 subunit composition at synaptic NMDARs but also with ast

116 GluN2 subunit composition at the synaptic site critically dete

117 evelopment and is associated with changes in subunit composition, but the mature channel composition

118 nAChRs expressed in the VTA exhibit diverse subunit compositions, but the functional and pharmacolog

119 In addition, we show that NMDAR subunit composition can be reverted back to the juvenile

120 implications, because a switch in the nAChR subunit composition can bring about a corresponding swit

121 that both the number of receptors and their subunit compositions can be altered.

122 Together our data suggest that multiple KCNQ subunit compositions can mediate the ImAHP, and that the

123 During development, the synaptic NMDARs subunit composition changes, switching from predominance

124 dual ATPase subunit loss on mSWI/SNF complex subunit composition, chromatin targeting, DNA accessibil

125 and altered postsynaptic glutamate receptor subunit composition, coinciding with a reduction in syna

126 sential for cell survival and has a distinct subunit composition compared to the eukaryal counterpart

127 Diversity in nAChR subunit composition complicates the development of selec

128 ion reveals a novel mechanism by which NMDAR subunit composition confers specificity to the program o

129 NMDAR subunit composition defines their biophysical properties

130 Thus, the subunit composition-dependent stimulation by DHA demonst

131 The subunit composition determines channel conductance prope

132 Thus, because subunit composition dictates key channel properties, suc

133 cessed generating various forms differing in subunit composition due to the presence or absence of N-

134 ents that capitalize on the heterogeneity of subunit composition during assembly and exchange reactio

135 change from a GluN2B- to a GluN2A-dominated subunit composition during postnatal development.

136 identify a category of tetramers that have a subunit composition equivalent to an octameric building

137 r results underscore the importance of NMDAR subunit composition for memory destabilization and sugge

138 ptic GluN2B responses, effecting a switch in subunit composition from GluN2B to GluN2A, a process nor

139 uired for viability and differs in structure/subunit composition from its eukaryal counterpart, it is

140 ynaptic N-Methyl-D-aspartate (NMDA) receptor subunit composition from predominantly GluN2B to GluN2A,

141 Dopamine depletion alters the subunit composition further, rendering Kir2 channels in

142 To date, AMPAR subunit composition has been quantitatively evaluated on

143 ate derivative dependent pathways, ribosomal subunit composition, hormone signaling, wound response,

144 a crucial unanswered question is the role of subunit composition in observed NMDAR mechanosensitivity

145 olecular methods to alter glutamate receptor subunit composition in olfactory bulb granule cells, the

146 gression may be mediated by changes in NMDAR subunit composition in the PFC, and point to a critical

147 tical events in determining changes in AMPAR subunit composition in the response to ischaemia.

148 in experience-dependent regulation of NMDAR subunit composition in vivo.

149 (GABA(A) R) subtypes, distinguished by their subunit composition, in striatal synapses.

150 +) block was suggested to reflect an unusual subunit composition including the NR2C and NR3A subunits

151 Receptor subunit composition is believed to play a major role in

152 Their subunit composition is developmentally regulated.

153 the function of these subunits and receptor subunit composition is essential for understanding the p

154 of the S. pombe SAGA complex showed that its subunit composition is identical to that of Saccharomyce

155 In yeast, COX subunit composition is regulated by COX5a and COX5b gene

156 We show that this specialized subunit composition is required for ES cell maintenance

157 Distinct Mediator subunit composition is thought to contribute to gene reg

158 elopmental stage-specific regulation of PRC2 subunit composition leads to a switch from canonical sil

159 Pentamers with distinct subunit compositions localize differentially at synaptic

160 As TRP channels with specific subunit compositions may have different functional prope

161 NMDA responses depends strongly on receptor subunit composition: NR1/2A and NR1/2B receptors are mor

162 e prevalent in developing seeds likely has a subunit composition of 4alpha4beta(1), is most active at

163 e that ubiquitylation can directly alter the subunit composition of a core component of the transcrip

164 The subunit composition of alpha-amino-3-hydroxyl-5-methyl-4

165 trafficking events seem to be driven by the subunit composition of AMPA receptor tetramers.

166 The number and subunit composition of AMPARs at synapses determines the

167 nge in the synaptic current, by changing the subunit composition of AMPARs at the parallel fibre-to-c

168 ary visual cortex (area V1), the density and subunit composition of AMPARs differ among cortical laye

169 provides a functional quantification of the subunit composition of AMPARs in the CNS and suggests no

170 Subsequent analysis revealed that a subunit composition of AMPK (alpha2beta2gamma1) is prefe

171 Heart failure induced a shift in the subunit composition of ASICs within muscle afferents, wh

172 esis; however, the mechanisms regulating the subunit composition of BAF/Brg1 complexes, in particular

173 tiple subtypes of IP3R are co-expressed, the subunit composition of channels cannot be specifically d

174 most nothing is known about the structure or subunit composition of channels formed by TRPM1 or any o

175 The subunit composition of ECF transporters is similar to th

176 s, thus making it difficult to establish the subunit composition of functional receptors.

177 The subunit composition of GABA(A) receptors influences thei

178 To establish how the subunit composition of GABAARs influences their ability

179 ignificant brain-regional alterations in the subunit composition of glutamate ionotropic receptors.

180 However, the minimal subunit composition of gustatory receptors required for

181 Thus, how the subunit composition of heterotetrameric IP3R channels co

182 a membrane and simultaneously determines the subunit composition of hundreds of individual protein co

183 ative kinesin-1 and cytoplasmic dynein motor subunit composition of individual, endogenous amyloid pr

184 method has mainly been used to determine the subunit composition of ion channels and receptors at the

185 s a functional signature that depends on the subunit composition of KCNQ2/3 channels, allowing us to

186 ry could be attributed to differences in the subunit composition of Kir2 channels.

187 re liquid chromatography, while the size and subunit composition of larger PAs were characterized usi

188 tracellular transport and steady-state motor subunit composition of mammalian prion protein (PrP(C))

189 ) and other techniques, we have compared the subunit composition of Mediator in three different struc

190 ested that H2Bub1 could either influence the subunit composition of methyltransferase complexes or di

191 advanced proteomic methods can determine the subunit composition of multi-protein complexes.

192 The subunit composition of N-methyl D-aspartate receptors (N

193 of nAChR density (Bmax ) and changes in the subunit composition of nAChRs.

194 roteomics approach, we show that a switch in subunit composition of neural, ATP-dependent SWI/SNF-lik

195 The subunit composition of neuronal TRPC channels remains un

196 Furthermore, the p38 kinase MAPK directs the subunit composition of NF-kappaB following UVB irradiati

197 Whether the subunit composition of NMDA receptors (NMDARs) controls

198 Subunit composition of NMDA receptors (NMDARs) determine

199 tral nervous system, there is a shift in the subunit composition of NMDA receptors (NMDARs) resulting

200 parallel with a developmental switch in the subunit composition of NMDA receptors from NR2B to NR2A.

201 However, since the putative subunit composition of NMDA receptors on oligodendrocyte

202 regulated by synapse-specific changes in the subunit composition of NMDA-type glutamate receptors (NM

203 glutamate receptor ionotropic NMDA 2 (GluN2) subunit composition of NMDARs determines whether they ac

204 the length of targeting presequences and the subunit composition of organellar processing peptidases

205 hat GluR1-S845 phosphorylation can alter the subunit composition of perisynaptic AMPARs by providing

206 Thus, CRL4(Cdt2) also regulates the subunit composition of Pol delta during the cell cycle.

207 The number and subunit composition of postsynaptic AMPA receptors (AMPA

208 Changes in the subunit composition of postsynaptic AMPA-type glutamate

209 osomal assembly step to regulate the variant subunit composition of potassium channels.

210 nd a single-molecule method to determine the subunit composition of proteins in the plasma membrane o

211 The subunit composition of recombinant GABA(A) receptors (GA

212 The subunit composition of SAGA was the same in each tissue;

213 The content and globulin subunit composition of soybean proteins are known to aff

214 We identified differences in the subunit composition of subcomplexes of ovine complex I a

215 s, selective trafficking mechanisms regulate subunit composition of surface hERG channels.

216 tic plasticity manifested as a switch in the subunit composition of synaptic AMPA receptors (AMPARs)

217 can induce a lasting change in the number or subunit composition of synaptic AMPA receptors (AMPARs).

218 The subunit composition of synaptic AMPA receptors can under

219 The number, synaptic localization and subunit composition of synaptic AMPARs are tightly regul

220 The subunit composition of synaptic and extrasynaptic NMDA r

221 The precise subunit composition of synaptic ionotropic receptors in

222 The subunit composition of synaptic NMDA receptors (NMDAR),

223 Furthermore, we analyze the subunit composition of synaptic NMDA receptors in CA1 py

224 In addition, the subunit composition of synaptic NMDARs changes in chroni

225 ding on the pattern of NMDAR activation, the subunit composition of synaptic NMDARs is under extremel

226 Here we explore the subunit composition of synaptic NMDARs on hippocampal in

227 These data suggest that MPAE alters the subunit composition of synaptic NMDARs, leading to impai

228 ed to different GluN1/GluN2A to GluN1/GluN2B subunit composition of synaptic NMDARs.

229 t is required for (a) maintaining the proper subunit composition of the complex and (b) cell cycle pr

230 Switching this selective subunit composition of the complex in rod photoreceptors

231 The subunit composition of the enzyme appears to vary with c

232 acts in opposition to Pum in regulating the subunit composition of the glutamate receptor.

233 ibodies failed to conclusively determine the subunit composition of the glutamate receptors on DB1 bi

234 The subunit composition of the holo-SWI/SNF and BAF57-deplet

235 uch regulation is typically dependent on the subunit composition of the ionotropic receptor or channe

236 Our results establish the subunit composition of the NALCN complex, uncover the in

237 hycocyanin (APC) in the antenna complex, the subunit composition of the phycobiliproteins, and the te

238 of synaptic transmission and a change in the subunit composition of the postsynaptic glutamate recept

239 Although the subunit composition of the PSII supercomplexes in compar

240 t of synapses is proposed to depend upon the subunit composition of the receptor.

241 To elucidate the subunit composition of the receptors we tested its pharm

242 The subunit composition of the residual alpha6-containing GA

243 The subunit composition of these bridges was unknown, althou

244 physiological importance, the structure and subunit composition of thylakoid FtsH complexes remain u

245 The subunit composition of VRACs determines electrophysiolog

246 These findings support the notion that the subunit composition of VTA GIRK channels is a critical d

247 e in excellent agreement and reveal that the subunit composition of yeast V(1)-ATPase is A(3)B(3)DE(3

248 t any instant, there is heterogeneity in the subunit compositions of PSII complexes within the cell.

249 e partially attributed to differences in the subunit compositions of their nuclear pore complexes.

250 In this study, we report that the subunit compositions of these complexes in striatum unde

251 To examine the effects of subunit composition on GABAR function in situ, we took a

252 f the absence of methods for assessing motor subunit composition on individual vesicular cargos.

253 hus, circuit-based therapies targeting NMDAR subunit composition on PV cells may provide novel treatm

254 their subcellular location rather than their subunit composition or mobility.

255 on of AMPA receptors without modifying their subunit composition or single-channel conductance.

256 ic NMDA-receptor EPSCs, without changing the subunit composition or the protein levels of NMDA-recept

257 s not associated with changes in the levels, subunit composition, or gross subcellular distribution o

258 c alterations in GABA(A) receptor (GABA(A)R) subunit composition over the ovarian cycle correlated wi

259 nsgenic mice to investigate the link between subunit composition, phosphorylation, and dopamine recep

260 Based on their subunit compositions, Pols IV and V clearly evolved as s

261 Because NMDA receptor subunit composition profoundly affects synaptic plastici

262 h a change in glutamate and glycine receptor subunit composition quantified via mRNA levels.

263 oRNAs primarily regulate Drosophila receptor subunit composition rather than overall receptor abundan

264 Emerging evidence suggests that the core subunit composition regulates distinct biological proces

265 lex in vitro and have identified the minimum subunit composition required for histone H3K4 methylatio

266 h levels of pS6 and demonstrate altered GluR subunit composition, resembling those of normal immature

267 ux through AMPARs triggers a switch in AMPAR subunit composition, resulting in loss of Ca(2+) permeab

268 cified by, for example, receptor location or subunit composition seem to govern glutamate-induced exc

269 The AMPA-type glutamate receptor (AMPAR) subunit composition shapes synaptic transmission and var

270 te this, both the terminal and the extension subunit compositions show little changes, while the mean

271 Despite that both terminal and extension subunit compositions show very small changes, mean degre

272 ture of PSI(PsaJF) and a monomeric PSI, with subunit composition similar to the viral PSI, providing

273 Despite decades of study, the subunit composition, subunit arrangement, and molecular

274 IC50 values varied with stereochemistry and subunit composition, suggesting that it may be possible

275 d TvoK, is of an apparent molecular mass and subunit composition that is consistent with the hetero-o

276 We also detected a shift in NMDAR subunit composition that, in contrast to the cell-wide s

277 dendritic GABAA receptors comprise distinct subunit compositions that are regulated differentially b

278 els located on spines depends on the channel subunit composition, the activity of kinases and phospha

279 Aside from the subunit composition, the N-terminal modification and pho

280 Depending on their subunit composition, these receptors exhibit distinct ph

281 create tetrameric channels with a predefined subunit composition to explore the functionality of hete

282 meostatic plasticity regulate synaptic AMPAR subunit composition to increase the contribution of Ca(2

283 Instead, PICK1 permits changes in AMPAR subunit composition to occur in conjunction with synapti

284 mber of GABAA receptors (GABARs) of the same subunit composition to preexisting synapses.

285 tisubunit complex has a similar but distinct subunit composition to that of the Drosophila ADA2A-cont

286 Xenopus laevis optic nerve regeneration, NF subunit composition undergoes progressive changes that c

287 is heavily dependent upon the GABAA receptor subunit composition underpinning tonic inhibition, and o

288 NMDA receptor subunit composition varies throughout the brain, providi

289 The subunit composition was determined by luminescence reson

290 purified from primary keratinocytes, and its subunit composition was determined by mass spectrometry.

291 Subunit composition was unchanged.

292 Selectivity for PAs by subunit composition was variable between treatments, but

293 why different results for hippocampal AMPAR subunit composition were obtained using co-immunoprecipi

294 (PRC1) multi-protein complexes with diverse subunit composition whose functions are incompletely und

295 ecular framework for the regulation of NMDAR subunit composition with implications for synaptic plast

296 ematopoietic gamma-secretase has an atypical subunit composition with significantly altered subunit s

297 We observed a one-to-one similarity in subunit composition with their mammalian counterparts, w

298 tic contact formation is determined by their subunit composition, with the N-terminal ECDs of each of

299 alignment of synaptic AMPA and NMDA receptor subunit composition within specific subtypes of interneu

300 n complexes display remarkable plasticity in subunit composition, yet how a new subunit assembled int