ライフサイエンスコーパス: suis

1 nt (38.8% for M. haemofelis and 31.1% for M. suis).

2 ZYH33 of the zoonotic pathogen Streptococcus suis.

3 cy, focussing on suilysin from Streptococcus suis.

4 ecies and subsequently serotyped as Brucella suis.

5 Streptococcus pyogenes, S. agalactiae and S. suis.

6 a species: B. abortus, B. melitensis, and B. suis.

7 ide polymorphisms with B. melitensis than B. suis.

8 hare a common ancestor that diverged from B. suis.

9 y with cell morphology and attenuation of B. suis.

10 s of Brucella abortus, B. melitensis, and B. suis.

11 cessary for the intracellular survival of B. suis.

12 tasis in the zoonotic pathogen Streptococcus suis.

13 in the opportunistic pathogen Streptococcus suis.

14 lla abortus, B. melitensis, B. canis, and B. suis.

15 Bordetella bronchiseptica, and Streptococcus suis.

16 em from the zoonotic pathogen, Streptococcus suis.

17 atural product gene cluster in Streptococcus suis.

18 ae, Streptococcus pyogenes and Streptococcus suis.

19 ch correlated well with host clearance of S. suis.

20 .5743) compared to S. pyogenes (1.03) and S. suis (0.57).

21 SSU05_1971 on the reverse strand) in the S. suis 05ZYH33 that causes streptococcal toxin shock-like

22 is (6 persons), C. felis (6 persons), and C. suis (1 person) infection.

23 p died within 1 week after challenge with S. suis (10 of 11 in each of two trials).

24 co-regulated genes, we searched the Brucella suis 1330 and B. abortus 2308 genomes for genes with an

25 te 9-941 and compare it to those of Brucella suis 1330 and Brucella melitensis 16 M.

26 Only B. suis 1330 appears to have an intact beta-ketoadipate pat

27 mpleted Brucella melitensis 16M and Brucella suis 1330 genomes have facilitated the investigation of

28 minal processing protease (CtpA) of Brucella suis 1330 is a member of a novel family of endoproteases

29 pon which the published sequence of Brucella suis 1330 is based and describe the differences between

30 ld isolates compared to the newly revised B. suis 1330 reference genome identified on average 13, 15,

31 sic infectious Brucella reference strain, B. suis 1330, was also used.

32 n and liver, but were less efficient than B. suis 1330.

33 Here, we found that S. suis 2 can escape phagocytic clearance by adenosine synt

34 cate that Ssads play an important role in S. suis 2 escaping human innate immunity in the context of

35 ant roles in developing therapies against S. suis 2 infection.

36 he most common clinical manifestations of S. suis 2 infection.

37 ctions (Nudix hydrolase and DNA binding), S. suis 2 retains a single regulatory role in the modulatio

38 However, the mechanisms of S. suis 2 surviving in human blood remains unclear, so to i

39 Ssads could impair PMN's defense against S. suis 2 with decreasing of oxidative activity and degranu

40 Streptococcus suis serotype 2 (S. suis 2) is a highly invasive pathogen in pigs and humans

41 nated as Ssads (the adenosine synthase of S. suis 2).

42 q gene cluster, is specific to Streptococcus suis, a burdensome agricultural pathogen and zoonotic ag

43 pathogens through analysis of Streptococcus suis, a ubiquitous component of the respiratory microbio

44 The virulence factor S. suis adhesin P (SadP) recognizes the galabiose Galalpha1

45 fection with the nematode parasite Trichuris suis alters systemic cytokine levels, cellular cytokine

46 elA and RelQ are identified in Streptococcus suis, an important emerging zoonotic Gram-positive bacte

47 cted by CSF culture, including Streptococcus suis and Acinetobacter baumannii.

48 tently emerging from one subpopulation of S. suis and acquiring genes through horizontal transfer fro

49 40-fold coverage of adult male and female T. suis and approximately 80-Mb draft assemblies.

50 Only B. suis and B. canis isolates clustered together and could

51 We have investigated how B. suis and B. melitensis enter human monocytes and in whic

52 Genome sequencing of B. suis and B. melitensis revealed that both are complete d

53 In contrast to B. suis and B. melitensis, it was found that B. neotomae is

54 While occasional detection of C. suis and C. muridarum in poultry is reported here for th

55 ies-level identification among Streptococcus suis and its close relatives remains challenging due to

56 Trichuris suis and Oesophagostomum dentatum larvae were similarly

57 two closely related species, Actinobacillus suis and Pasteurella multocida.

58 ctiae, S. equi, S. mutans, S. pneumoniae, S. suis and S. uberis, as well as representative enterococc

59 mologues in Helicobacter pylori and Brucella suis and the archaeal type II secretion ATPase GspE, a u

60 distinct from "H. heilmannii" type 1 and "H. suis" and clustered with "H. heilmannii" types 2 and 4.

61 eria meningitidis, Haemophilus influenzae, S suis) and O tsutsugamushi, Rickettsia typhi/Rickettsia s

62 B. abortus, B. melitensis, B. suis, and B. canis produced identical PCR interspace pro

63 cella melitensis, Brucella abortus, Brucella suis, and Brucella canis were extracted and distributed

64 cella melitensis, Brucella abortus, Brucella suis, and Brucella canis) is problematic for many clinic

65 In Streptococcus mutans, Streptococcus suis, and species of the bovis, salivarius and pyogenic

66 regulatory cytokine IL-10 in response to T. suis antigens.

67 cause the strategies to target pathogenic S. suis are limited, new therapeutic approaches are needed.

68 Brucella abortus, B. melitensis, and B. suis are pathogenic to humans, whereas B. ovis and B. ne

69 sent, to our knowledge, the first case of S. suis arthroplasty infection and streptococcal toxic shoc

70 tients infected with B. abortus and Brucella suis as well as rabbit antisera prepared against killed

71 a that are distinct from type 1 and from "H. suis." As "H. heilmannii" type 1 predominates in people,

72 . congolense, T. theileri, T. simiae, and T. suis assays.

73 lates from farms with no known history of S. suis-associated disease.

74 of Wb and S708 phages that are lytic for B. suis, B. abortus and B. neotomae.

75 s were shared between only B. abortus and B. suis, B. abortus shared more fragments and had fewer nuc

76 species-Brucella abortus, B. melitensis, B. suis, B. canis, and B. ovis-using whole-genome compariso

77 and unlike B. abortus, B. melitensis, and B. suis, B. neotomae has not been observed to infect humans

78 Streptococcus suis bacteria are one of the most serious health problem

79 S. suis bacteria express capsular polysaccharides (CPS) a m

80 nella strains was 84 to 92%, with that of E. suis being most similar to that of the H. felis strain f

81 une electron microscopy demonstrated that S. suis BgaC is an atypical surface-anchored protein in tha

82 Therefore we concluded that S. suis BgaC is an atypical surface-exposed protein without

83 Bioinformatics analyses revealed that S. suis BgaC shared the conserved active sites (W240, W243

84 ucella abortus-Brucella melitensis, Brucella suis-Brucella canis, Brucella ovis, and Brucella ceti.

85 d three from cows: all were classified as S. suis by MALDI-TOF MS but tested negative by the recN PCR

86 d swine and three from cows identified as S. suis by MALDI-TOF MS, but which tested negative by a rec

87 Besides Gln, H. suis can also convert glutathione (GSH) to glutamate, an

88 hat administration of the nematode Trichuris suis can be beneficial in treating various immune disord

89 fection with highly pathogenic Streptococcus suis can cause septic shock, which is characterized by h

90 S. suis can induce disease and also quietly reside on mucos

91 oteins in data banks, such as Tritrichomonas suis, Candida albicans, and Saccharomyces cerevisiae pro

92 Streptococcus suis causes disease in pigs worldwide and is increasingl

93 Helicobacter (H.) suis causes gastric pathologies in both pigs and humans.

94 This study evaluated 2,379 S. suis central nervous system (CNS) isolates from diagnost

95 killed S. suis vaccine (group 6) prior to S. suis challenge or a single 2-ml intramuscular dose of an

96 sows were randomly assigned to Streptococcus suis challenge or control subgroups.

97 tion for three consecutive days following S. suis challenge was the most effective regimen for minimi

98 ion-only group and 5 of 23 piglets in the S. suis-challenge-only group (1 of 12 in trial 1 and 4 of 1

99 Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont M

100 role in the activation of neutrophils and S. suis clearance, which further reduced severe inflammatio

101 We identified a zoonotic S. suis clone that diverged from a non-zoonotic clone by me

102 imizing disease associated with PRRSV and S. suis coinfection.

103 duced mortality associated with PRRSV and S. suis coinfection.

104 e supporting the proposal of a structured S. suis complex and identify S. suis sensu stricto-specific

105 sms, support the recognition of a broader S. suis complex, demonstrate the need for genome-based meth

106 y form a broader, previously unrecognized S. suis complex.

107 isolates (no species name), B. canis, and B. suis, confirmed that all but the latter two species coul

108 The B. suis CtpA protein shared up to 77% homology with CtpA pr

109 n of glutamine (Gln) in the medium during H. suis culture.

110 tilocus sequence typing (MLST) scheme for S. suis developed in order to begin to address these issues

111 94 S. suis isolates obtained from various S. suis diseases and from asymptomatic carriage representin

112 Most of the piglets in the PRRSV-S. suis dual-infection group developed suppurative meningit

113 verall, 20 out of 22 piglets in the PRRSV-S. suis dual-infection group died within 1 week after chall

114 ries still report such isolates simply as S. suis, due to the limited resolution of current diagnosti

115 ustness of the core metabolic pathways in S. suis during the infection process.

116 find that several pathogenic lineages of S. suis emerged in the 19th and 20th centuries, during an e

117 We report a fatal case of Brucella suis endocarditis initially misdiagnosed by automated id

118 tance at < or =11 mm, and for Actinobacillus suis, Erysipelothrix rhusiopathiae, and Streptococcus su

119 Application of this method to six Brucella suis field isolates compared to the newly revised B. sui

120 ll as by a marked host range (e.g., Brucella suis for swine, B. melitensis for sheep and goats, and B

121 e sequences, the Haemobartonella spp. and E. suis formed a distinct clade more closely related to Myc

122 The sequence of E. suis from a pig in Illinois was identical to that from a

123 from Agrobacterium tumefaciens and Brucella suis (G-) and to the transfer protein TcpC from Clostrid

124 , and both reactions are catalyzed by the H. suis gamma-glutamyltranspeptidase (GGT).

125 Analysis of the B. suis genome reveals transport and metabolic capabilities

126 B. abortus, Brucella melitensis and Brucella suis; Group III was composed of Wb and S708 phages that

127 Labeling experiments with S. suis grown ex vivo in blood or cerebrospinal fluid refle

128 g isotopologue patterns in amino acids of S. suis grown under in vitro and ex vivo conditions.

129 Streptococcus suis has emerged as an important cause of bacterial meni

130 Although the virulence genes of S. suis have been extensively studied, the mechanisms by wh

131 closely related genetically to Streptococcus suis have recently been formally recognized or proposed,

132 rate that the released proteins of larval T. suis have significant immunomodulatory capacities and ef

133 from Agrobacterium tumefaciens and Brucella suis Here, we studied the structure and function of TraE

134 h additional diagnostic tools for precise S. suis identification, and (iv) VAGs remain an unreliable

135 istence of B. abortus, B. melitensis, and B. suis in mice up to 4 weeks after infection, since deleti

136 etracycline has been described for Chlamydia suis in pigs.

137 o Gb4 could be used to selectively target S. suis in systemic disease without interfering with commen

138 l role of PEP carboxylation for growth of S. suis in the host was supported by experiments with a PEP

139 fficacy and safety of the helminth Trichuris suis in therapy of ulcerative colitis.

140 plementation with Gln was shown to temper H. suis induced gastritis and epithelial (hyper)proliferati

141 Thus, S. suis induced thymocyte apoptosis through a p53- and casp

142 The proximal colon of T. suis-infected pigs exhibited general inflammation around

143 showed clinical symptoms compatible with S. suis infection 24-48 hours after ingestion of SS2.

144 a more severe proinflammatory response to S. suis infection and increased the mortality rate, while i

145 aken together, these results suggest that S. suis infection can cause atrophy of the thymus and induc

146 nse, and the outcome of highly pathogenic S. suis infection in a mouse model.

147 A 21-day T. suis infection in four pigs induced a significant change

148 Moreover, S. suis infection increased cleavage of caspase-3, caspase-

149 end labeling (TUNEL) assays revealed that S. suis infection induced apoptosis in CD3(+), CD14(+), and

150 S. suis infection resulted in a rapid depletion of mitochon

151 s to examine its effect on the outcome of S. suis infection.

152 ated in swine spleen cells in response to S. suis infection.

153 food-borne transmission in Asia, zoonotic S. suis infections are mainly occupational hazards elsewher

154 S. suis interaction with human and pig IEC correlates with

155 ore, B. melitensis but not B. abortus nor B. suis interfered with the invasive capacity of EVT-like c

156 Brucella suis is a causative agent of porcine brucellosis.

157 We found that B. suis is a highly divergent clade with extensive intraspe

158 Streptococcus suis is a neglected zoonotic pathogen that has to adapt

159 Streptococcus suis is a significant cause of mortality in piglets and

160 Streptococcus suis is a zoonotic swine pathogen and a major public hea

161 S. suis is also a very successful colonizer of mucosal surf

162 Streptococcus suis is an emerging swine-associated zoonotic agent that

163 Streptococcus suis is an emerging zoonotic pathogen, and causes sepsis

164 ted with CNS disease.IMPORTANCEStreptococcus suis is an important and complex systemic bacterial path

165 Streptococcus suis is an important pathogen of pigs and occasionally c

166 assical growth experiments, we found that S. suis is auxotrophic for Arg, Gln/Glu, His, Leu, and Trp

167 According to genomic analysis, S. suis is divided into asymptomatic carriage, respiratory

168 The pig whipworm Trichuris suis is important in swine production because of its neg

169 Streptococcus suis is one of the most important zoonotic bacterial pat

170 Streptococcus suis is part of the pig commensal microbiome but strains

171 Brucella suis is the causative agent of swine brucellosis and is

172 e pathogenicity and zoonotic potential of S. suis is yet to be fully realized.

173 suis, is a cysteine protease distinct from previous char

174 The cleavage patterns of DNA from S. suis isolated from the sows matched the cleavage pattern

175 matched the cleavage patterns of DNA from S. suis isolated from their respective pigs.

176 was to characterize the diversity of 208 S. suis isolates collected between 2014 and 2017 across Nor

177 otential, we compared whole genomes of 98 S. suis isolates from human patients and pigs with invasive

178 e genetic markers that differentiated 115 S. suis isolates into disease-associated and non-disease-as

179 sekeeping gene fragments from each of 294 S. suis isolates obtained from various S. suis diseases and

180 o be a competitive method to characterize S. suis isolates recovered from pigs on UK farms and one th

181 llection of 50 previously uncharacterized S. suis isolates, in comparison to existing methods used to

182 indicator of genetic relatedness between S. suis isolates, these findings suggest that capsular gene

183 methods used to characterize and subtype S. suis isolates.

184 Both for H. pylori and H. suis, it has been hypothesized that the degradation of G

185 retory (E/S) products of first-stage (L1) T. suis larvae (Ts E/S) using LC-MS/MS analysis and examine

186 Of note, infection by T. suis led to a significant shift in the metabolic potenti

187 of MALDI-TOF MS results, can misidentify S. suis-like isolates.

188 nfirm extensive taxonomic diversity among S. suis-like organisms, support the recognition of a broade

189 e starvation induced adaptive response in S. suis makes a great contribution to understanding better

190 suggest that the Haemobartonella spp. and E. suis may be reclassified in the same genus in the family

191 stribution of disease-causing isolates of S. suis, most isolates previously characterized as of high

192 amplified from purified DNA of Eperythrozoon suis, Mycoplasma genitalium, and Bartonella bacilliformi

193 Streptococcus suis negatively impacts swine health, posing diagnostic

194 Intriguingly, the S. suis NrtR naturally contains a single amino acid substit

195 etails about the impact and mechanisms of S. suis on specific populations of thymic and immune cells

196 annosyldiacylglycerol found in Streptococcus suis or alpha-mannosylceramide demonstrated markedly les

197 previously identified as unique to either B. suis or B. melitensis were present in the B. abortus gen

198 eceived three weekly doses of 2500 Trichuris suis ova (n = 45) or placebo (n = 44) over 6 months.

199 Trichuris suis ova (TSO) have been tested for therapeutic applicat

200 o assess the safety or efficacy of Trichuris suis ova in allergies, inflammatory bowel diseases, mult

201 ormation supports further investigation of T suis ova in patients with immune-mediated diseases, part

202 Patients received 2500 Trichuris suis ova or placebo orally at 2-week intervals for 12 we

203 suggests that cytokines induced by Trichuris suis ova treatment do not alter allergic reactivity to p

204 C cytokine responses were not affected by T. suis ova treatment.

205 Trichuris suis ova were obtained from the US Department of Agricul

206 Eggs of the pig whipworm (Trichuris suis ova) have been shown to be safe in multiple studies

207 oduction of T. suis-specific cytokines in T. suis ova-treated participants, allergen-specific cytokin

208 a sub-cohort of randomized participants (T. suis ova-treated, n = 12, Placebo-treated, n = 10).

209 However, little is known about the S. suis population structure, the clonal relationships betw

210 es may be moving horizontally through the S. suis population.

211 agnoses, alongside the complex ecology of S. suis, poses significant challenges in comprehending this

212 B. suis primarily infects pigs and is pathogenic to humans.

213 disease, exposure to the helminth Trichuris suis reduces disease activity.

214 llous trophoblasts (EVTs), B. abortus and B. suis replicated within single-membrane acidic lysosomal

215 4 bp and 742,431 bp for M. haemofelis and M. suis, respectively, are typical of mycoplasma species, h

216 s MIT 94-022 and MZ 640285, and Helicobacter suis, respectively.

217 sults indicate that zoonotic potential of S. suis results from gene loss, recombination and horizonta

218 . abortus, Brucella melitensis, and Brucella suis results in rough, attenuated mutants which fail to

219 supplementation, and analyzed for Chlamydia suis S-45 infectivity.

220 T. suis secretes extremely high amounts of PGE2 (45-90 ng/m

221 We conclude that T. suis secretes PGE2 to suppress proinflammatory responses

222 The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammat

223 cing revealed that most isolates were not S. suis sensu stricto but instead belonged to other recogni

224 identified 38 genes conserved in >=95% of S. suis sensu stricto genomes that may support future marke

225 ing revealed that only four isolates were S. suis sensu stricto, while most others belonged to Strept

226 a structured S. suis complex and identify S. suis sensu stricto-specific markers that may inform impr

227 nged intranasally with 2 ml of Streptococcus suis serotype 2 (10(8.30) CFU/2 ml).

228 Streptococcus suis serotype 2 (S. suis 2) is a highly invasive pathoge

229 dercooked pork is a risk factor for human S. suis serotype 2 (SS2) infection.

230 Streptococcus suis serotype 2 is an encapsulated bacterium and one of

231 Streptococcus suis serotype 2 is an important bacterial pathogen of sw

232 Furthermore, nrtR knockout in S. suis serotype 2 reduces its capacity to form biofilms an

233 ydrogenase (GDH) enzymes of 19 Streptococcus suis serotype 2 strains, consisting of 18 swine isolates

234 Isolates of Streptococcus suis serotype 5 collected from three sows and nine of th

235 on with human and pig IEC correlates with S. suis serotype and genotype, which can explain the zoonot

236 ens for the development of semi-synthetic S. suis serotypes 2 and 9 glycoconjugate veterinary vaccine

237 Oligosaccharides resembling the CPS of S. suis serotypes 2, 3, 9, and 14 have been synthesized, gl

238 We identified 29 S. suis serotypes and 4 reclassified serotypes as putative

239 sufficient for defining a pathotype, (ii) S. suis serotypes and STs associated with CNS infection are

240 r americanus) or porcine whipworm (Trichuris suis) show that they are safe and may be effective thera

241 es, an active component was purified from T. suis soluble products (TsSPs) that suppress---- TNF and

242 Treatment with Trichuris suis soluble products during monocyte-to-macrophage diff

243 ations worldwide, making detection of the S. suis species in asymptomatic carrier herds of little pra

244 Despite increased production of T. suis-specific cytokines in T. suis ova-treated participa

245 Our studies showed that smooth virulent B. suis strain 1330 (S1330) prevented programmed cell death

246 e with virulent B. abortus strain 2308 or B. suis strain 1330 but no protection against B. melitensis

247 lasma haemofelis strain Ohio2 and Mycoplasma suis strain Illinois, which are the first available geno

248 infected macrophages and rough attenuated B. suis strain VTRS1 (a vaccine candidate) induced strong m

249 type, thus increasing the knowledge about S. suis strains circulating in the United States.

250 Characterization of S. suis strains originating from pigs with histologic confi

251 ttle geographical clustering of different S. suis subpopulations, and the bacterium undergoes high ra

252 brunensis sp. nov., as well as Streptococcus suis subsp.

253 eptococcus suis was revised to Streptococcus suis subsp.

254 of the initial description of Streptococcus suis subsp.

255 h can be delineated from other Streptococcus suis subsp.

256 ation of ova from the pig whipworm Trichuris suis (T. suis; TSO) has been proposed for the treatment

257 sipelothrix rhusiopathiae, and Streptococcus suis tested on enriched chocolate Mueller-Hinton agar, s

258 sent crystal structures of VirB8 of Brucella suis, the causative agent of brucellosis, and ComB10, a

259 p)ppGpp in glucose starvation response in S. suis, the growth curves and transcriptional profiles wer

260 all frequency of NHPGH species was 10 for H. suis (three duodenal ulcer, three gastritis, and four ga

261 ova from the pig whipworm Trichuris suis (T. suis; TSO) has been proposed for the treatment of allerg

262 soluble products derived from the Trichuris suis (TsSP) significantly affect the differentiation of

263 administered with emulsifying adjuvants, S. suis type 2 CPS is able to induce potent IgM and isotype

264 gate prototypes were prepared by coupling S. suis type 2 CPS to tetanus toxoid, and the immunological

265 F), and IL-10, was observed in mice after S. suis type 2 infection.

266 S. suis type II was recovered from their brains and joints.

267 nged intranasally with strain MN 87555 of S. suis type II.

268 ection and disease following challenge by S. suis type II.

269 dissect the central metabolic activity of S. suis under different conditions of nutrient availability

270 tramuscular doses of an autogenous killed S. suis vaccine (group 6) prior to S. suis challenge or a s

271 ort the complete genome sequence of Brucella suis VBI22, which was isolated from raw milk from an inf

272 ing organisms: Brucella melitensis, Brucella suis, Vibrio cholera, Yersinia pestis, and Francisella t

273 The hexamer of Brucella suis VirB11 (BsB11), like that of the Helicobacter pylor

274 trol of NAD(+) homeostasis contributes to S. suis virulence.

275 Furthermore, B. suis was determined to be paraphyletic in our analyses,

276 that fewer than half of cases from which S. suis was isolated from the brain had histologic evidence

277 The recombinant BgaC protein of S. suis was purified to homogeneity.

278 Streptococcus suis was revised to Streptococcus suis subsp.

279 n and potential bioterrorism agent, Brucella suis, was determined.

280 nderstand the genetic basis of disease in S. suis, we study the genomes of 375 isolates with detailed

281 f H. felis, and two strains of Eperythrozoon suis were sequenced and compared.

282 cine proximal colon in response to Trichuris suis (whipworm) infection using 16S rRNA gene-based and

283 Comparison of B. suis with Brucella melitensis has defined a finite set o

284 We compared in vitro interaction of S. suis with human and porcine intestinal epithelial cells

285 Culture of T. suis with several cyclooxygenase (COX) inhibitors that i

286 milarity of the 16S rRNA gene sequence of E. suis with those of three Haemobartonella strains was 84