ライフサイエンスコーパス: sulfate group

1 ient to shield the charge contributed by the sulfate group.

2 ndent on the positioning of at least one 6-O-sulfate group.

3 ted di-, tri-, and pentasaccharides with one sulfate group.

4 e residue and the attachment position of the sulfate group.

5 s positioned to recognize the substrate beta-sulfate group.

6 charides, notably including variants with 3O-sulfate groups.

7 ose containing a combination of 2-O- and 6-O-sulfate groups.

8 ttranslationally modified by the addition of sulfate groups.

9 ic oligosaccharides as well as phosphate and sulfate groups.

10 uded the positioning of the methyl ether and sulfate groups.

11 2-O-sulfated iduronate residues, but no 6-O-sulfate groups.

12 in chains that lack their N-, C6-O-, or C2-O-sulfate groups.

13 drugs owing to their high number of anionic sulfate groups.

14 tions to transiently form adsorbed SO(3) and sulfate groups.

15 side chains terminated by negatively charged sulfate groups.

16 that binding is specific to the presence of sulfate groups.

17 onal coordination of the ammonium across the sulfate groups.

18 eived neither cobra venom factor nor dextran sulfate (group 1), there was rapid destruction of islets

19 gnificantly less frequently in the magnesium sulfate group (1.9% vs. 3.5%; relative risk, 0.55; 95% C

20 resolution of IDA was higher in the ferrous sulfate group (29% vs 6%; P = .04).

21 n length (tetramers and hexamers), number of sulfate groups (3-7), sulfate patterns (sulfate position

22 59 completed the trial (28 [70%] in ferrous sulfate group; 31 [78%] in iron polysaccharide complex g

23 methoxy (1), hydroxy (2), carbamate (3), or sulfate groups (4).

24 n the iron complex group than in the ferrous sulfate group (58% vs 35%, respectively; P = .04).

25 lfation pattern (statistical distribution of sulfate groups along a chain), ionic strength, CS intrin

26 ee of sulfation, but also the arrangement of sulfate groups along the GAG chain, plays a key role in

27 was most important, the 2-O-sulfate and 6-O-sulfate groups also contributed to neuregulin-1 binding

28 acquired HIV infections, 25 in the cellulose sulfate group and 16 in the placebo group, with an estim

29 school age was 14% (88/629) in the magnesium sulfate group and 18% (110/626) in the placebo group (ri

30 es of sulfatides require the presence of the sulfate group and are inversely related to the FA chain

31 ence went from 83.7% to 46.2% in the ferrous sulfate group and from 84.6% to 47.1% in the HIP group.

32 not significantly different in the magnesium sulfate group and the placebo group (11.3% and 11.7%, re

33 Salt bridges between the sulfate group and two lysine residues appear to compensa

34 ssays indicate that salt bridges between the sulfate group and two lysine residues compensate for the

35 egmented polyurethane (F-PU-S), with pendant sulfate groups and a flexible hydrocarbon backbone, exhi

36 , glycosulfopeptides permit the placement of sulfate groups and glycans of precise structure at defin

37 clearance depends on specific subclasses of sulfate groups and not on overall charge of the chains.

38 cid conditions without affecting the O- or N-sulfate groups and purified by reversed-phase high-perfo

39 th four sulfate groups, CL-1S, with a single sulfate group, and CL-4OH, a nonionic analog with four h

40 pelling evidence that a specific subclass of sulfate groups, and not the overall charge of HS, permit

41 s controlled by sulfotransferases, which add sulfate groups, and sulfatases (Sulf), which remove 6-O-

42 r HLGAG oligosaccharides, provided that most sulfate groups are deprotonated.

43 d cell-surface GAG and, in particular, their sulfate groups are important in binding and modulation o

44 sulfate groups contribute to inhibition, 2-O-sulfate groups are less critical than either N- or 6-O-s

45 her validate that glycosaminoglycans but not sulfate groups are required for polyplex uptake and tran

46 mportant for specificity and that at least 2 sulfate groups are required to cross-link spatially sepa

47 GAGs to mediate RSV infection, only certain sulfate groups are required.

48 is not crucial, and (c) additional negative sulfate groups are well tolerated in certain cases, such

49 The amount and position of sulfated groups are highly variable, thus allowing diffe

50 ulfate, there is a very prominent role for N-sulfate groups, as opposed to a relatively small apparen

51 ile, has been employed for installation of a sulfate group at the 3-position of a range of galacto- a

52 ubstrate for Sulf-1, and substitution of the sulfate group at the 6-O position of the d-glucosamine u

53 like hexasaccharide, bearing an additional O-sulfate group at the non-reducing end, which precludes b

54 The sulfate group at tyrosine 21 contributes substantially t

55 L-selectin-initiated cell adhesion; (b) the sulfate groups at C6 on the glucosamine residues play a

56 luronic acid) and 6S/4S/2S represent O-ester sulfate groups at C6/C4/C2 sites.

57 Modifications include the addition of sulfate groups at specific positions on sugar residues a

58 reas for AgaB oligosaccharides containing C6-sulfate groups at the -4, +1, and +3 positions are still

59 ransferases (3OSTs) catalyze the addition of sulfate groups at the 3-OH site of glucosamine in hepara

60 ar strategy that enables the installation of sulfate groups at the designated positions along the sug

61 nionic polymersome with efficient display of sulfate groups at the surface.

62 hat vGPCR is posttranslationally modified by sulfate groups at tyrosine residues within its N-termina

63 ersistent, consistent with the notion of six sulfate groups being both essential and sufficient for a

64 as modestly affected by the presence of a 17-sulfate group but severely impaired by the presence of a

65 ple charge interaction between the virus and sulfate groups but instead involves a specific GAG struc

66 SULF2 degrades HSPGs by removing 6-O sulfate groups, but had no previously known role in diab

67 nstrates that molecules completely devoid of sulfate groups can activate antithrombin effectively and

68 l (CL) related surfactants: CL-4S, with four sulfate groups, CL-1S, with a single sulfate group, and

69 by a scaffold-based mechanism, in which the sulfate groups comprising GAGs interact primarily with T

70 asaccharide compositions based on acetyl and sulfate group content.

71 Although all N- and O-sulfate groups contribute to inhibition, 2-O-sulfate gro

72 ds (NulOs, e.g., bacterial sialic acids) and sulfated groups contributing to the negative charge in a

73 th their preferential ability to co-ordinate sulfate groups), could form a single extended binding si

74 modified heparins lacking N-sulfate and 2-O-sulfate groups did not block very low density lipoprotei

75 sulfation reactions utilizing the universal sulfate group donor 3'-phosphoadenosine 5'-phosphosulfat

76 of the chain folding as well as the pendant sulfate groups for the fusion-induced antiviral activity

77 in the case of PdGH110, accommodation of the sulfate groups found on lambda-carrageenan.

78 strogen sulfotransferase (EST) transfers the sulfate group from 3'-phosphoadenosine 5'-phosphosulfate

79 Sulfation is the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate

80 ylgalactosamine-4-sulfatase; ARSB) removes 4-sulfate groups from chondroitin-4-sulfate (C4S) and derm

81 1 (Sulf1) act as endosulfatases removing 6-O-sulfate groups from heparan sulfate (HS) in the extracel

82 lar endosulfatases, enzymes which remove 6-O sulfate groups from heparan sulfate chains, diminishes m

83 fatase-2 (SULF2), an enzyme that removes 6-O sulfate groups from heparan sulfate proteoglycans (HSPGs

84 tase and 6-O-sulfatase enzymes that cleave O-sulfate groups from specific locations of the HSGAG poly

85 ted endosulfatase Qsulf1 selectively removes sulfate groups from the 6-O position of sugars within th

86 rted onto the cell surface to liberate the 6-sulfate groups from the internal d-glucosamine residues

87 ARSB is the enzyme that removes 4-sulfate groups from the non-reducing end of chondroitin

88 Recombinant human ARSG is able to cleave 3-O-sulfate groups from these residues as well as from an au

89 nzymatic removal of the non-reducing end 2-O-sulfate group had little effect on the 1:1 interaction w

90 revolutionized proteomics, the fragility of sulfate groups has limited its usefulness in the analysi

91 modified heparins reveals that 2-O- and 6-O-sulfate groups have potent bypass-inducing activity.

92 that the negatively charged sugar residue or sulfate group in gangliosides is one of the important si

93 er control values was detected in the copper sulfate group in terms of the aggregate modulus.

94 n EDD of GST, precluding localization of the sulfate group in that peptide.

95 on patterns depending on the position of the sulfate group in the heterocycle.

96 specific to the level and distribution of 4-sulfate groups in C4S.

97 sensitive to the content or arrangement of O-sulfate groups in heparan sulfate.

98 contacts between basic residues in gp120 and sulfate groups in proteoglycans, HIV-1 may exploit these

99 r the first time, the unique distribution of sulfate groups in the CS chains of placental CSPGs and t

100 The majority of the sulfate groups in the CSPGs are clustered in CS chain do

101 electively sulfated heparins indicate that O-sulfated groups in HS are critical for FGF10 signaling a

102 um ion complexation of HLGAGs stabilizes the sulfate groups, increases the relative abundances of bac

103 oups are less critical than either N- or 6-O-sulfate groups, indicating that inhibitory activity is d

104 x) blood group determinant, bringing several sulfate groups into close proximity and creating large n

105 Structure-function studies reveal that the sulfate group is an important determinant for efficient

106 sually a phosphate group and less commonly a sulfate group, leads to diverse structural and functiona

107 rs of 3,4-dihydroxyhex-5-enoic acid with the sulfate group located at the C-3 or C-4 position.

108 Only heparin chains lacking the N-sulfate group lost the ability to neutralize infection,

109 degree of sulfation and the position of the sulfate groups mainly determine biological function.

110 er of monosaccharide residues, acetylations, sulfate groups, multiple charges, and exchanges between

111 hazard ratio of infection for the cellulose sulfate group of 1.61 (P=0.13).

112 ulfo-Le(x), and forms a salt bridge with the sulfate group of 4'-sulfo-Le(x).

113 ts with both the iron-sulfur cluster and the sulfate group of adenosine 5'-phosphosulfate.

114 The 6-O-sulfate group of heparin plays a pivotal role in mediati

115 Whereas the N-sulfate group of heparin was most important, the 2-O-sul

116 In addition, the sulfate group of p-nitrocatechol sulfate was found to be

117 interaction, possibly communicating with the sulfate group of sulfatide by hydrogen bonding and/or sa

118 2-O-sulfate group of the I ring and the 6-O-sulfate group of the A ring are not.

119 l for site-specific binding, whereas the 2-O-sulfate group of the I ring and the 6-O-sulfate group of

120 etween this cationic amino acid and the core-sulfate group of the N-glycan is proposed to reduce mobi

121 n bonds either to the caboxylate or to the 4-sulfate groups of C4-S.

122 and galactose-6-sulfatase (GALNS) hydrolyze sulfate groups of CS.

123 th take advantage of binding of carboxyl and sulfate groups of GAGs to trivalent neodymium.

124 The sulfate groups of heparan sulfate- and chondroitin sulfa

125 m groups of FN-C/H II and carboxylate and/or sulfate groups of heparin.

126 e represented by peptide F-9 and the heparan sulfate groups of HSPG.

127 e ideally placed to receive the N-acetyl and sulfate groups of sulfated GalNAc residues of glycosamin

128 idues in positions 29, 42, and 77 in binding sulfate groups of the dp8 and dp10 forms of heparin.

129 ate-immobilized heparin, indicating that the sulfate groups of the glycosaminoglycan mediate p17 inte

130 bridging oxygen between the 5'-phosphate and sulfate groups of the PAPS molecule as is seen in the PA

131 In contrast, 6-sulfo sialyl Lex containing a sulfate group on the N-acetylglucosamine residue did not

132 In these interactions, the sulfate groups on C-2 were shown to interact more intens

133 Microarray results also indicate that sulfate groups on GAGs are essential for CHIKV binding a

134 The clustering of sulfate groups on heparin and its polymeric nature are e

135 inding depends on the amount and patterns of sulfate groups on HS, which are controlled by various HS

136 GSC number is sensitive to the levels of 6-O sulfate groups on HS.

137 An SPGG molecule containing approximately 10 sulfate groups on positions 2 through 6 of the pentagall

138 The sulfate groups on suramin form stable electrostatic inte

139 The installation of sulfate groups on the carbohydrate residues of glycoprot

140 rin on glypican binding also indicate that O-sulfate groups on the heparan sulfate chains play a crit

141 residues well placed to bind to clusters of sulfate groups on the high affinity dodecasaccharide.

142 are also modified by functionally important sulfate groups on their NH(2)-terminal tyrosines.

143 Through sulfated groups on their glycosaminoglycan chains, hepar

144 We propose that either the sulfate groups (or the sulfation pattern) at the reducin

145 tperformed heparin molecules with one or two sulfate groups per disaccharide unit in terms of enhance

146 Furthermore, heparin molecules with three sulfate groups per disaccharide unit outperformed hepari

147 ecasaccharides, only those with two or three sulfate groups per molecule showed maximum IRBC inhibiti

148 eterogeneity of modifications and the labile sulfate group present major challenges for liquid chroma

149 Replacement of the sterol hydroxyls with sulfate groups, prior to displacement with GSH, afforded

150 engineered heparan compounds containing 2-O-sulfate groups rescued Sdc1(-/-) mice from AILI by poten

151 ttributed to the presence of zirconium-bound sulfate groups structurally characterized using single-c

152 83k) and with limited changes in the cyclic sulfate group, such as 4,5-cyclic sulfite 87a/b.

153 es, contained genes responsible for NulO and sulfate group synthesis or transfer.

154 More women in the magnesium sulfate group than in the nimodipine group needed hydral

155 The Methylocystis mbtins have a sulfate group that helps stabilize the Cu(I) forms, resu

156 molecules (500-900 Da) were also enriched in sulfate groups that appeared bound to UDOM.

157 An array of sulfate groups that are essential to HS's function were

158 t it is the negative charge, rather than the sulfate group, that confers inhibitory efficacy.

159 is challenging due to the lability of their sulfate groups, the high heterogeneity of modifications,

160 chimeric form of HNK-1ST was shown to add a sulfate group to a precursor, GlcAbeta1-->3Galbeta1-->4G

161 Introduction of an additional sulfate group to the 3-OH of residue H flanking a putati

162 ion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate cha

163 thods for the site-selective introduction of sulfate groups to carbohydrates are thus of interest.

164 that modify sugar chains through transfer of sulfate groups to specific positions on the sugar moieti

165 synthesis and catalyzes the transfer of the sulfate groups to the sugar moiety of heparan sulfate.

166 ever, owing to their lability elimination of sulfate groups upon desorption/ionization is often encou

167 ns illustrates the absolute requirement of N-sulfate groups vicinal to the epimerization site for sub

168 bin increased from 7.9 to 11.9 g/dL (ferrous sulfate group) vs 7.7 to 11.1 g/dL (iron complex group),

169 A glycolipid 3-sulfate group was essential for the T cell suppression,

170 Retention of sulfate groups was also observed in electron detachment

171 ted hepatocytes, whereas heparin lacking 6-O-sulfate groups was as active as unaltered heparin.

172 The importance of the sulfate groups was delineated by using desulfated analog

173 To elicit the effect, the presence of sulfate groups was necessary, yet not sufficient, as cer

174 to typical ECD behavior, localization of the sulfate groups was not possible.

175 ,2-a]carbazole also possessing sulfamate and sulfate groups, was isolated from two separate New Zeala

176 ol) and heparins with different positions of sulfate groups, we quantify how SO(3)(-) and COO(-) cont

177 (ii) Sulfate groups were not detectable in the binding fracti

178 In both ionization modes, the sulfate groups were retained on the backbone, which allo

179 -ancorinolate B, which contain sulfamate and sulfate groups, were isolated from the aqueous extract o

180 an occupant electron density that best fit a sulfate group, which was present in the crystallization

181 designed to conjugate with phosphodiester or sulfate groups, while accommodating various functional g

182 The degree of sulfation and position of the sulfate groups will also affect functions such as immune

183 otein contacts would occur by interaction of sulfate groups with basic amino acid residues on the sur

184 reted molecules that specifically remove 6-O-sulfate groups within the highly sulfated regions on HS.

185 e, an extracellular enzyme which removes 6-O sulfate groups without increasing 2-O sulfation.