ライフサイエンスコーパス: sulfated

1 nd 12 metabolites (methylated, glucuronided, sulfated).

2 Sulfated 2-acrylamido-2-methyl-1-propanesulfonic acid (A

3 linker N, N'-bis (acryloyl) cystamine (BAC), sulfated 2-acrylamido-2-methyl-1-propanesulfonic acid (A

4 on sequon on Gal-GlcNAc and GalNAc-GlcNAc of sulfated-3-Gal, sulfated-6-GlcNAc, and sulfated-4-GalNAc

5 ulfoglycans containing sulfated-6-GlcNAc and sulfated-4-GalNAc residues.

6 Ac of sulfated-3-Gal, sulfated-6-GlcNAc, and sulfated-4-GalNAc.

7 ated and fucosylated sulfoglycans containing sulfated-6-GlcNAc and sulfated-4-GalNAc residues.

8 -GlcNAc and GalNAc-GlcNAc of sulfated-3-Gal, sulfated-6-GlcNAc, and sulfated-4-GalNAc.

9 in the fibromodulin N-terminal domain are O-sulfated, a posttranslational modification often involve

10 rbed on Bronsted acidic sulfated ZrO2 (ZrS), sulfated Al2O3 (AlS), and ZrO2-WO3 (ZrW).

11 Carrageenans are sulfated alpha-1,3-beta-1,4-galactans found in the cell

12 Idraparinux is a fully O-sulfated alpha-methyl glycoside of heparin pentasacchari

13 r (CCR5) recognition through CCR5's tyrosine-sulfated amino (N) terminus, release of the gp41 fusion

14 CR5 mutants severely damaged in the tyrosine-sulfated amino terminus or extracellular loop 2.

15 To limit intestinal absorption, C7-sulfated analogues designed to avoid active and passive

16 We discover 20 sulfated and 4 acetylated N-glycans on IgGs.

17 This library covers 4-O-sulfated and 6-O-sulfated oligosaccharides ranging from

18 rat gut model, we found intact, methylated, sulfated and both methylated and sulfated quercetin soph

19 Expanded searches also revealed many sulfated and complex glycans that remained hidden to the

20 allowing the characterization of both lowly sulfated and highly sulfated HS oligosaccharides.

21 Based on the controlled production of both sulfated and nonsulfated variants in plants, we could un

22 f 26 neutral, sulfated, sialylated, and both sulfated and sialylated core 1 (Galbeta1-3GalNAcalpha1-)

23 OMP)] matrices compared with monosulfated (4-sulfated) and unsulfated hyaluronic acid matrices in mic

24 ormones and processes it to a unique, triple-sulfated, and N-terminally truncated product distinct fr

25 ant metabolites (hydroxylated, methoxylated, sulfated, and quinone)] in concentration-response (10 nM

26 one composed of 3-alpha-Glc1 units partially sulfated at 2- and 4-positions and branches of Pyr(4,6)a

27 o glycopeptide sequencing, of which 514 were sulfated at the site-specific locations.

28 ty that we predict to be posttranslationally sulfated at two conserved tyrosine residues.

29 a cajennense tick can be posttranslationally sulfated at two tyrosine residues, albeit as a mixture o

30 because of the unique positioning of the 3-O-sulfated beta-galactose headgroup.

31 method is illustrated by the synthesis of a sulfated beta-mannuronic acid disaccharide.

32 ial origin (aromatic compounds, secondary or sulfated bile acids, and benzoate) and estrogen metaboli

33 Sulfated BP-PLGA microspheres were capable of loading LY

34 acid CIF peptide ligands, which are tyrosine sulfated by the tyrosylprotein sulfotransferase TPST/SGN

35 of Siglec-8 toward different sialylated and sulfated carbohydrate ligands and determined the structu

36 structures, langerin has the ability to bind sulfated carbohydrate ligands as 6-sulfated galactosides

37 Sulfated carbohydrates have been implicated in diverse b

38 HIV-1 entry by adding or removing a tyrosine-sulfated CCR5 peptide from the culture medium.

39 FPX is a valid model for the highly sulfated cell signalling molecule heparan sulfate (HS).

40 fluenza virus particles using novel magnetic sulfated cellulose particles is presented and compared t

41 rifugation method, use of the novel magnetic sulfated cellulose particles reduced the influenza A vir

42 ions and increased concentrations of the non-sulfated chondroitin disaccharide D0a0 and the disacchar

43 This nematode produces large amounts of non-sulfated chondroitin in addition to low-sulfated chondro

44 non-sulfated chondroitin in addition to low-sulfated chondroitin sulfate chains.

45 for these complexes; indeed, for the highly sulfated chondroitin sulfate motifs, CS-E and CS-D, ther

46 Heparin is a highly sulfated, complex polysaccharide and widely used anticoa

47 parated mixtures, with a particular focus on sulfated compounds.

48 were identified in biological fluids, mainly sulfated conjugates of caffeic and ferulic/isoferulic ac

49 We have examined the effect of increased sulfated content of galactosylceramides (sulfatides) on

50 oth the cellular receptor CD4 and a tyrosine-sulfated coreceptor to infect its target cells.

51 gstrom cryo-EM structures of E51, a tyrosine-sulfated coreceptor-mimicking antibody, complexed with a

52 2 as the site of binding for the most potent sulfated coumarin.

53 Overall, sulfated coumarins represent first-in-class, sub-maximal

54 thrombin was impaired in the presence of the sulfated coumarins suggesting that allosteric partial in

55 We synthesized a focused library of some 36 sulfated coumarins to discover two agents that display s

56 We could indeed detect sulfated CS in both wild type and mutant nematodes.

57 also describe the synthesis of unnatural 6-O-sulfated CS pentasaccharides containing either a 6-O-sul

58 ional composite of CS-A and CS-E [4- and 4,6-sulfated CS-GAG (COMP)] matrices compared with monosulfa

59 a sulfated heparan sulfate analogue, and by sulfated cyclodextrin, a sulfated small molecule.

60 Here, we identified a sulfated derivative of the Escherichia coli polysacchari

61 iched in galactosylceramide (GalCer) and its sulfated derivative sulfatide.

62 the form of methylated, glucuronidated, and sulfated derivatives (in total, 21 derivatives were iden

63 group of LC-PCBs and their hydroxylated and sulfated derivatives by selective displacement of the fl

64 rmore, analysis of a minilibrary of variably sulfated derivatives of Escherichia coli K5 polysacchari

65 emonstrated the dual regulatory role of high-sulfated derivatives on the biological activity of endot

66 ccharide to be converted into 12 differently sulfated derivatives.

67 -sulfotransferases-1 (3-OST1) to provide 3-O-sulfated derivatives.

68 from Hp (particularly reduced sulfation and sulfated disaccharide content), and that they are each d

69 companied by a decrease in iduronic acid 2-O-sulfated disaccharide structures.

70 ts displayed a relative increase in mono-6-O-sulfated disaccharides accompanied by a decrease in idur

71 parallel increase in iduronic acid mono-2-O-sulfated disaccharides.

72 and septic humans was enriched in 2-O- and N-sulfated disaccharides; furthermore, the presence of the

73 Two sulfated diterpene glycosides featuring a highly substit

74 The tyrosine-sulfated domain and the leucine-rich repeat domain both

75 gth fibromodulin and its N-terminal tyrosine-sulfated domain purified from tissue, as well as recombi

76 d ADAMTS2/14-mediated cleavage of a tyrosine-sulfated domain.

77 ized by the individual 1 cell line lacks 2-O-sulfated domains but had an increase in N- and 6-O-sulfa

78 ed domains but had an increase in N- and 6-O-sulfated domains demonstrating functional impairment of

79 pro-pathogenic activity is dependent on 2-O-sulfated domains in HS, indicating that the effects of s

80 These results demonstrate that 2-O-sulfated domains in syndecan-1 HS halt disease progressi

81 effects of different PGs and their assorted sulfated epitopes.

82 posed mechanisms of sulfatase catalysis is a sulfated FGly intermediate.

83 gene, dehydroepiandrosterone (DHEA) and its sulfated form (DHEA-S), and characteristics of attention

84 percentage of bovine sperm bound to the 3'-O-sulfated form of Lewis A (suLe(A)) trisaccharide and sia

85 portantly, the peptide is only active in the sulfated form, further confirming the importance of the

86 aran sulfate occurring in N-acetylated and N-sulfated forms, and as the unmodified amine.

87 es, including the characterization of labile sulfated functional groups.

88 The small molecule sulfated GAG antagonist bis-2-methyl-4-amino-quinolyl-6-

89 y controlling Wnt3a availability through its sulfated GAG chains.

90 imental and computational study revealed how sulfated GAG derivatives (sGAG) influence the interplay

91 The sulfated GAG oligosaccharides derived from cartilage pos

92 This research establishes that chicken sulfated GAG polysaccharides can enhance iron uptake by

93 Both the cartilage and skin sulfated GAG polysaccharides showed greater ferritin for

94 t demonstration of surfen as an inhibitor of sulfated GAG signaling to stem GBM invasion.

95 Heparin, the most highly sulfated GAG, binds sCT in the pH interval 3-7.

96 nt positive charge, and its interaction with sulfated GAG-polymers were quantitatively investigated u

97 While no sulfated GAGs have been found in marine sponges, chondro

98 HSV-1 recognized all sulfated GAGs, but not the nonsulfated hyaluronan, indic

99 n inexpensive, colorimetric urinary assay of sulfated GAGs.

100 Agars are sulfated galactans from red macroalgae and are composed

101 tain polyanionic, low-methylated pectins and sulfated galactans, a feature shared with the cell walls

102 Chondrus crispus is a marine red alga with sulfated galactans, called carrageenans, in its extracel

103 alactosamine dominated, we also detected 6-O-sulfated galactosamine residues.

104 rmed by unique loop regions, recognizing 6-O-sulfated galactose dictates tight specificity distinct f

105 ggesting that P1 does not mediate binding to sulfated galactose.

106 y to bind sulfated carbohydrate ligands as 6-sulfated galactosides in the Ca(2+)-dependent binding si

107 o receive the N-acetyl and sulfate groups of sulfated GalNAc residues of glycosaminoglycans such as c

108 epolymerized for compositional analysis, 3-O-sulfated glucosamine at the reducing ends appears to be

109 hat specifically degrades HS chains with 3-O-sulfated glucosamine at the reducing-end.

110 in the peptide backbone and acid sensitive O-sulfated glycan chains.

111 Heparinase treatment, which digests anionic sulfated glycan polymers, before exposure rendered cells

112 ycopeptide containing aspartic acid and an O-sulfated glycan was synthesized.

113 Human naive and memory B-cells express sulfated glycans as high affinity CD22 ligands, which ar

114 similar applications based on permethylated sulfated glycans have not been fully investigated.

115 Siglec-F recognizes sialylated sulfated glycans in glycan-binding assays, but the ident

116 based nanoLC-MS/MS analysis of permethylated sulfated glycans in negative ion mode and demonstrate th

117 ) are a class of heterogeneous, often highly sulfated glycans that form linear chains consisting of u

118 ed mucin preparations carried sialylated and sulfated glycans, bound to eosinophils and induced their

119 nkage isomers, 26 structural isomers, and 27 sulfated glycans.

120 exchange cartridges facilitated detection of sulfated glycans.

121 an easy way to separate and hence enrich the sulfated glycans.

122 ted to suggest that the shifting between the sulfated glycoconjugates as distinct targets of CTX A2,

123 ugh interactions with adhesion receptors and sulfated glycolipids (Figure 1, bottom).

124 We report here on supramolecular sulfated glycopeptide nanostructures, which display a tr

125 Food grade sulfated glycosaminoglycan (GAG) polysaccharides were su

126 Heparan sulfate (HS) is a sulfated glycosaminoglycan abundant on the cell surface

127 osition of AF-specific extracellular matrix (sulfated glycosaminoglycan and collagen type I), indicat

128 result from differences in intracellular HA, sulfated glycosaminoglycan concentration, apoptosis, or

129 Starting from the observation that the sulfated glycosaminoglycan-specific peptide exerts a dif

130 that specifically degrade heparan sulfate, a sulfated glycosaminoglycan.

131 This interaction is blocked by heparin, a sulfated glycosaminoglycan.

132 Structural characterization of sulfated glycosaminoglycans (GAGs) by mass spectrometry

133 sulfate (CS) proteoglycan (CSPG)-associated sulfated glycosaminoglycans (GAGs) that are selectively

134 y langerin was demonstrated to interact with sulfated glycosaminoglycans (GAGs), in a Ca(2+)-independ

135 importance of tissue-specifically expressed, sulfated glycosaminoglycans (GAGs), like HS, in determin

136 ients that are achieved by interactions with sulfated glycosaminoglycans (GAGs).

137 Proteoglycans are proteins that carry sulfated glycosaminoglycans (GAGs).

138 of glycans, sialylated oligosaccharides and sulfated glycosaminoglycans (GAGs).

139 cated TcdA lacking the CROPs, and identified sulfated glycosaminoglycans (sGAGs) and low-density lipo

140 Here, we employ a haploid screen to identify sulfated glycosaminoglycans (sGAGs) as its second glycan

141 cell surface glycocalyx with upregulation of sulfated glycosaminoglycans and charged glycoproteins.

142 c bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in t

143 IMP-3 K26A/K45A retained higher affinity for sulfated glycosaminoglycans than K42A/K110A and exhibite

144 nes for the biosynthesis of sialic acids and sulfated glycosaminoglycans were analyzed in the anammox

145 scent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox

146 Highly sulfated glycosaminoglycans within the cartilage matrix

147 ents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).

148 mpressive moduli, biochemical content (i.e., sulfated glycosaminoglycans, collagen), and histological

149 g of CpClec-Fc was specifically inhibited by sulfated glycosaminoglycans, particularly heparin and he

150 ng peptide tool that specifically recognizes sulfated glycosaminoglycans, we analyzed the role of mem

151 anular sludge, focussing on sialic acids and sulfated glycosaminoglycans.

152 ly shown to be enhanced by heparin and other sulfated glycosaminoglycans.

153 fication of various fucosylated, sialylated, sulfated glycotopes and definitive determination of the

154 The amount and position of sulfated groups are highly variable, thus allowing diffe

155 Through sulfated groups on their glycosaminoglycan chains, hepar

156 litative and quantitative analysis of highly sulfated Hep/HS compounds in a manner not possible with

157 Herein, we show that highly sulfated Hep/HS isomers may be resolved by gated-trapped

158 lines of evidence suggested the role of 3-O-sulfated heparan sulfate (3-OS HS) during HCMV-mediated

159 all molecule that masks sGAGs, by GM-1111, a sulfated heparan sulfate analogue, and by sulfated cyclo

160 of cells in sodium chlorate, indicating that sulfated heparan sulfate chains are required for nuclear

161 indings indicate that circulating 2-O- and N-sulfated heparan sulfate fragments contribute to septic

162 izable syndrome and emphasize a role for 2-O-sulfated heparan sulfate in human neuronal, skeletal, an

163 nalysis of GAG isomers, in particular highly sulfated heparin (Hep) and heparan sulfate (HS), is chal

164 so allowed relative quantification of highly sulfated heparin isomers.

165 These contain lower sulfated Hp-like and heparan sulfate (HS), as well as ot

166 decreased glomerular expression of a highly sulfated HS domain, and albuminuria.

167 terization of both lowly sulfated and highly sulfated HS oligosaccharides.

168 GAGs from Idua(-/-) BM and specifically 2-O-sulfated HS, elevated in Idua(-/-) BM, both inhibited CX

169 thelial cells and that these effects require sulfated HS.

170 ed binding region to chondroitin sulfate and sulfated hyaluronan but not to the non-sulfated hyaluron

171 e and sulfated hyaluronan but not to the non-sulfated hyaluronan, confirming binding specificity.

172 fate) and compared our results to chemically sulfated hyaluronan.

173 ot require compounds such as hydrocarbons or sulfated hydrocarbons, however, it cannot be explained o

174 Four new metabolites of PCMC (hydroxylated, sulfated/hydroxylated, sulfated PCMC, and glucuronidated

175 Both antibodies were efficiently sulfated in planta on coexpression of an engineered huma

176 As human trypsins are post-translationally sulfated in the autolysis loop, we also assessed the eff

177 ic Env interact with E51, revealing tyrosine-sulfated interactions with gp120 mimicking CCR5 interact

178 tiation of neutral glycan isomers as well as sulfated isomeric structures, where the sulfate was reta

179 the HS structure revealed that the highly O-sulfated K5 polysaccharides inhibited HMPV infection, id

180 ryos a exhibited region-specific increase in sulfated keratan sulfate and a concomitant reduction in

181 protein kinase (CCaMK)-dependent manner, and sulfated LCOs enhanced the colonization of Populus by L.

182 Keratan sulfate (KS) is a sulfated linear polymer of N-acetyllactosamine.

183 Heparan sulfate, a sulfated linear polysaccharide modified in a complex var

184 e group of glycosaminoglycans (GAGs), highly sulfated linear polysaccharides.

185 face via interactions with surface-localized sulfated lipid and protein receptors.

186 Interactions of these sulfated metabolites of LC-PCBs with HSA, however, have

187 Several acetylated, hydroxylated, and/or sulfated metabolites were identified, some of which were

188 y little is known about the function of most sulfated metabolites, the synthesis of activated sulfate

189 etabolites, together with glucuronidated and sulfated metabolites, were detected.

190 ice immune receptor XA21 is activated by the sulfated microbial peptide required for activation of XA

191 The hydrated sulfated MOF exhibits a good catalytic performance for t

192 ed, phosphorylated, sialylated, and multiply sulfated moieties as modifications of oligomannosidic, h

193 ylacrylamide based NPs that incorporate both sulfated N-acetylglucosamine and hydrophobic monomers we

194 onsisting of 927 N-glycan structures and 387 sulfated N-glycan compositions.

195 LC-MS/MS) were used to identify N-glycan and sulfated N-glycan compositions.

196 sferase-1 (GlcNAc6ST-1) failed to synthesize sulfated N-glycans and exhibited abnormal myelination an

197 light the tremendous structural diversity of sulfated N-glycans and strongly suggest potential functi

198 Sulfated N-glycans are biologically important structures

199 Here, we report that sulfated N-glycans are involved in peripheral nervous sy

200 Major sulfated N-glycans were identified in both porcine and m

201 myelin glycoproteins contain highly abundant sulfated N-glycans.

202 ie-Tooth neuropathy, has abundant GlcNAc-6-O-sulfated N-glycans.

203 The high-throughput analysis of sulfated N-glycomes remains a daunting technical challen

204 c analyses enable rapid determination of new sulfated-N-glycan structures in large sets of influenza

205 of human-, swine-, and avian-origin viruses; sulfated Neu5Acalpha2-3 substructures were associated wi

206 n-6) polyunsaturated fatty acids (PUFAs), 2) sulfated neurosteroids, which play a role in brain devel

207 re essential for growth and development; low sulfated neurosteroids, which play a role in brain devel

208 d both undersulfated (NA) domains and highly sulfated (NS) domains as well as very well defined non-r

209 M. pneumoniae recognizes sialylated and sulfated oligosaccharide receptors to colonize the respi

210 the generation of comprehensive libraries of sulfated oligosaccharides for unlocking the "sulfation c

211 Three sulfated oligosaccharides of natural origin were chosen

212 This library covers 4-O-sulfated and 6-O-sulfated oligosaccharides ranging from trisaccharides to

213 energy activation methods for GAGs and other sulfated oligosaccharides.

214 tures of oligo-porphyrans, a class of highly sulfated oligosaccharides.

215 method for detection and characterization of sulfated oligosaccharides.

216 atively modulated by 5beta-reduced steroids, sulfated or carboxylated steroids, and beta-estradiol, w

217 s expand the "cationic" metal center-anionic sulfated oxide surface distances, and this separation/we

218 olid acid catalysts (cation-exchange resins, sulfated oxides, and acidic zeolites).

219 f PCMC (hydroxylated, sulfated/hydroxylated, sulfated PCMC, and glucuronidated PCMC) were identified

220 But only one metabolite, sulfated PCMC, was confirmed in wastewater and in urine.

221 nthomonas oryzae pv. oryzae (Xoo) produces a sulfated peptide named RaxX, which shares similarity to

222 at variations in sequences and structures of sulfated peptides.

223 measurements of self-binding forces of this sulfated polysaccharide and their chemically desulfated

224 Heparin is a linear, highly sulfated polysaccharide consisting of alternating glucos

225 and of purified calcium spirulan (Ca-SP), a sulfated polysaccharide contained therein.

226 rotein 2 significantly more than the natural sulfated polysaccharide heparin, and promoted regenerati

227 Heparan sulfate (HS) is a sulfated polysaccharide that decorates cell surface and

228 Heparan sulfate (HS) is a linear sulfated polysaccharide that is a component of the cell

229 Chondroitin sulfate (CS) is a sulfated polysaccharide that plays essential physiologic

230 Its sulfated polysaccharide units, which were characterized

231 with binding domains for the highly diverse sulfated polysaccharides are important growth factors in

232 m-dependent multivalent self-interactions of sulfated polysaccharides components of extracellular mem

233 Heparan sulfates (HS) are linear sulfated polysaccharides that modulate a wide range of p

234 Heparan sulfates are structurally diverse sulfated polysaccharides that reside at the surface of a

235 in infection in relevant models, we utilized sulfated polysaccharides, heparan sulfate mimetics, and

236 nt from other polyomaviruses, as it requires sulfated polysaccharides, such as heparan sulfates and/o

237 nds including dimethylsulfoniopropionate and sulfated polysaccharides.

238 ysaccharides alginates and fucose-containing sulfated polysaccharides.

239 Our discovery that sulfated progesterone metabolites are a prognostic indic

240 lant activity, a library of 34 homogeneously sulfated protein variants were rapidly assembled using o

241 o paves the way for economical production of sulfated proteins as therapeutic agents in mammalian sys

242 only a small fraction of the total predicted sulfated proteins has been identified to date.

243 imilar procedures can be applied to identify sulfated proteins in yeast and human proteome microarray

244 Among the 4256 E. coli K12 proteins, 875 sulfated proteins were identified using antisulfotyrosin

245 Heparan and chondroitin/dermatan sulfated proteoglycans have a wide range of roles in cel

246 nd infection via Ca(2+)-dependent binding to sulfated proteoglycans on intestinal epithelial cells.

247 re was significantly less total collagen and sulfated proteoglycans present in the type VI collagen-d

248 rter that promotes a ventral accumulation of sulfated proteoglycans, which is required for ventral PM

249 ed synthesis of matrix molecules, especially sulfated proteoglycans.

250 methylated, sulfated and both methylated and sulfated quercetin sophoroside in the plasma following j

251 Here we found that a synthetic sulfated RaxX derivative comprising 13 residues (RaxX13-

252 We further demonstrate that sulfated RaxX directly binds XA21 with high affinity.

253 tic cleavage of the glycoside bond between 3-sulfated rhamnose and uronic acid according to a beta-el

254 of disaccharide building blocks comprising 3-sulfated rhamnose linked to d-glucuronic acid (GlcUA), l

255 nd understudied group of eukaryotic tyrosine sulfated ribosomally synthesized, posttranslationally mo

256 tween amino acids of viral glycoproteins and sulfated saccharides on the GAG chain.

257 HS is composed of sulfated saccharides that are biosynthesized through a c

258 d-type and SOT1 knockdown trees suggest that sulfated salicinoids do not affect the feeding preferenc

259 x canescens) resulted in decreased levels of sulfated salicinoids in comparison to wild-type plants,

260 of P trichocarpa matched the accumulation of sulfated salicinoids in planta.

261 lar Lymantria dispar A potential role of the sulfated salicinoids in sulfur storage and homeostasis i

262 We identified two sulfated salicinoids, salicin-7-sulfate and salirepin-7-

263 sulfonyl C-9 substituent with the preferred sulfated scaffold.

264 We used an mAb and/or a multimeric synthetic sulfated sialoglycan ligand recognizing Siglec-8 in comb

265 and defined, showing a range of 26 neutral, sulfated, sialylated, and both sulfated and sialylated c

266 s positively charged molecules on the highly sulfated side chains of aggrecan.

267 Third, the sulfated SK (sSK) and sSK-related peptides were more pot

268 te analogue, and by sulfated cyclodextrin, a sulfated small molecule.

269 e number of N-glycan compositions, including sulfated species, identified from urinary exosomes and d

270 Sulfated steroids in the aqueous medium were then hydrol

271 hexane to separate free (unconjugated) from sulfated steroids.

272 the biosynthesis of estrogens from inactive sulfated steroids.

273 y be due to the complex, branched and highly sulfated structure of fucoidans, which also varies among

274 ondroitin-4-sulfate (C4S) is the predominant sulfated structure that regulates axonal guidance and gr

275 rder of hydrophilicity, with the more highly sulfated structures eluting first.

276 nternal d-glucosamine residues in the highly sulfated subdomains of HSPGs.

277 in two serotypes suggesting a propensity for sulfated-sugar binding.

278 work, we investigate the potential of highly sulfated synthetic glycomimetics to act as inhibitors of

279 sponses as intact heparin, (ii) that a fully sulfated tetrasaccharide isolated from bacterial heparin

280 found to be 17.0 nm, similar to those of the sulfated toxins gonyautoxin II and III.

281 f the Delta-2S-iduronate to expose the fully sulfated trisaccharide (GlcNS(6S)-IdoUA(2S)-GlcNS(6S)) d

282 Sulfated Tyr in such compounds was stable in neutral buf

283 l protein sulfotransferase 1, we installed O-sulfated tyrosine in CDR H3 of both bNAbs.

284 t-translational modification (PTM), namely O-sulfated tyrosine in the heavy chain complementarity det

285 l efficacy of PG9 and RSH is the presence of sulfated tyrosine residues in their antigen-binding regi

286 eptides in the PSY (plant peptide containing sulfated tyrosine) family.

287 second variable loop (V2) of gp120 contains sulfated tyrosines (Tys173 and Tys177) that in the CD4-u

288 rm, further confirming the importance of the sulfated tyrosines for function.

289 d variable loop (V3), functionally mimicking sulfated tyrosines in CCR5 and anti-coreceptor-binding-s

290 Homogenously sulfated variants of the proteins were efficiently assem

291 wo tyrosine residues, albeit as a mixture of sulfated variants.

292 In contrast, tyrosine sulfated versions displayed equivalent neutralising acti

293 o the mammalian cell produced bNAbs, but non-sulfated versions showed loss of neutralisation breadth

294 l as two posttranslationally modified sites, sulfated Y38 and phosphorylated S47.

295 t Cp*ZrBz2 /ZrS (Cp*=Me5 C5 , Bz=benzyl, ZrS=sulfated zirconia) catalyzes the single-face/all-cis hyd

296 d to the iridium center by its grafting onto sulfated zirconia, imbuing high levels of activity in el

297 )-3,5-dimethylphenyl) complex chemisorbed on sulfated zirconia, the molecular precursor for which was

298 ation of olefins was also facilitated by the sulfated zirconia-supported ( (dm)Phebox)Ir(III) complex

299 onating or electron-withdrawing groups, with sulfated zirconium oxide partially dehydroxylated at 300

300 A sulfated zirconium-based metal-organic framework, MOF-80

301 complexes are chemisorbed on Bronsted acidic sulfated ZrO2 (ZrS), sulfated Al2O3 (AlS), and ZrO2-WO3