ライフサイエンスコーパス: sulfatide

1 both sLeX and 3-sulfated galactosylceramide (sulfatide).

2 e II NKT cells recognize the self-glycolipid sulfatide.

3 id-transfer protein effectively present lyso-sulfatide.

4 s that recognize lipid components such as O4 sulfatide.

5 pids, and variations of the self-glycolipid, sulfatide.

6 rine, phosphatidylinositol, cholesterol, and sulfatide.

7 rebroside (GalC) and its sulfated derivative sulfatide.

8 galactolipids galactocerebroside (GalC) and sulfatide.

9 there was an exceptionally strong binding to sulfatide.

10 rebroside (GalC) and its sulfated derivative sulfatide.

11 containing hydroxylated fatty acids and with sulfatide.

12 alter selectin binding to sLex, heparin, or sulfatide.

13 N-terminal domain binds liposomes containing sulfatide.

14 eramide (GalCer) and its sulfated derivative sulfatide.

15 th micromolar affinities similar to that for sulfatide.

16 was found to contain 17 gangliosides and 13 sulfatides.

17 to the laminin coiled-coil dystroglycan and sulfatides.

18 of myelin 2-hydroxy galactosylceramides and -sulfatides.

19 by treatment of the substrate with SGGLs or sulfatides.

20 s for TSP1, heparan sulfate proteoglycan and sulfatides.

21 responsible for the lysosomal hydrolysis of sulfatides.

22 ng, including phospholipids, cholesterol and sulfatides.

23 eficient (ASA knockout) mice that accumulate sulfatides.

24 tides and 10 to 1,000 nM for C16:0 and C24:0 sulfatides.

25 We used chamber slides coated with sulfatide (3-O-sulfogalactosylceramide) to provide a bas

26 lethanolamines, 2 phosphatidylinositols), 10 sulfatides (5 hydroxylated species and 5 nonhydroxylated

27 -[14C]arachidonoyl-phosphati dylethanolamine:sulfatide (70:0.2:30) were incubated with the supernatan

28 s lipid binding activity with preference for sulfatide, a glycosphingolipid present in the outer leaf

29 Neutrophils stimulated with sulfatide, a ligand for the L-selectin receptor, or the

30 ein for arylsulfatase A in the hydrolysis of sulfatide, a lipid component of myelin.

31 We now show that SC expression of galactosyl-sulfatide, a Lm-binding glycolipid, precedes that of Lms

32 We identified sulfatide, a major constituent of CNS myelin, as a novel

33 egulatory mechanism following recognition of sulfatide, a self-glycolipid ligand for a subset of CD1d

34 Sulfatide accumulated, but galactosylceramide remained a

35 loss of Sap B function leads to progressive sulfatide accumulation in satellite cells surrounding th

36 We show that sulfatide accumulation significantly impacts the formati

37 that these inclusion bodies corresponded to sulfatide accumulation.

38 We therefore suggest that sulfatides act as counterions for interstitial ammonium

39 ids (in particular galactocerebroside and/or sulfatide) act as sensors and/or transmitters of environ

40 e platelet surface, and platelets expressing sulfatides adhere to P-selectin.

41 NS-resident microglia, are inactivated after sulfatide administration, and mice deficient in type I N

42 vine submaxillary mucins, and the glycolipid sulfatide, all of which present multivalent sialylated a

43 Strikingly, we found that the glycolipid Ag sulfatide also localized almost exclusively to early end

44 such that it is able to adhere to heparin or sulfatide and can reduce P-selectin adherence to these l

45 These data indicate that sulfatide and complex b-series gangliosides on the glial

46 o assess the functional interactions between sulfatide and gangliosides, CST (-/-) and GalNAc-T (-/-)

47 in are important in 987P fimbrial binding to sulfatide and glycoprotein receptors, suggesting differe

48 Thus, autoimmune responses to sulfatide and other lipids are present in individuals wi

49 omal storage of the acidic glycosphingolipid sulfatide and progressive demyelination.

50 r range of 5 to 1,000 nM for C18:0 and C24:1 sulfatides and 10 to 1,000 nM for C16:0 and C24:0 sulfat

51 Moreover, 71 sulfatides and 59 polar phospholipids (phosphatidylserin

52 normal nerve function.SIGNIFICANCE STATEMENT Sulfatides and complex gangliosides are membrane glycoli

53 Here, we show vital interdependent roles for sulfatides and complex gangliosides because double (but

54 These findings suggest that sulfatides and complex gangliosides on opposing axo-glia

55 In negative ion mode, MALDI favored sulfatides and free fatty acids, whereas NAPA spectra we

56 Sulfatides and gangliosides are raft-associated glycolip

57 te that two classes of sulfated glycolipids, sulfatides and HNK-1-reactive sulfoglucuronylglycolipids

58 type II NKT cells recognizes myelin-derived sulfatides and is selectively enriched in the CNS tissue

59 The lectin domain of brevican binds sulfatides and SGGLs in a calcium-dependent manner as ex

60 Intact, full-length brevican also binds both sulfatides and SGGLs.

61 er beta2-glycoprotein I forms a complex with sulfatides and thereby becomes a target for anti-phospho

62 d by phosphatidylcholine, sphingomyelin, and sulfatides and were not substantially stimulated by cere

63 roteoglycan, 3-sulfated galactosyl ceramide (sulfatide), and heparin.

64 directed against galactocerebroside sulfate (sulfatide); and RMAb, which is directed against galactoc

65 a1 contains major binding sites for heparin, sulfatide, and alpha-dystroglycan and plays a critical r

66 amide, glucosylceramide, galactosylceramide, sulfatide, and globotriaosylceramide are abnormally incr

67 inding to collagen IV, to bind to galactosyl sulfatide, and to selectively convert alpha-short arm de

68 nd CHO cells expressing P-selectin adhere to sulfatides, and anti-P-selectin antibodies inhibit this

69 ones corresponding to phosphatidylinositols, sulfatides, and gangliosides were recorded in negative i

70 hosphoethanolamines, glycerophospho-serines, sulfatides, and gangliosides.

71 th diverse targets such as heparan sulfates, sulfatides, and integrins on cell surfaces.

72 hermore, both anti-P-selectin antibodies and sulfatide antagonist MCSP significantly reverse platelet

73 e data presented here indicate that GalC and sulfatide are essential in proper CNS node and paranode

74 Sulfatides are expressed on the platelet surface, and pl

75 blasts become competent for BM assembly when sulfatides are intercalated into their cell surfaces.

76 Sulfatides are most highly modulated by wild-type p53 tr

77 de carrier(s) in human CSF demonstrated that sulfatides are specifically associated with apoE-contain

78 Sulfatides are sulfated glycosphingolipids expressed on

79 Sulfatides are sulfated glycosphingolipids present on th

80 c phospholipids, as commonly known, but also sulfatides are targets for most anti-phospholipid antibo

81 Sulfated galactosylceramides (sulfatides) are glycosphingolipids associated with chole

82 ously that an antibody to galactocerebroside/sulfatide arrested terminal differentiation, suggesting

83 can powerfully inhibit axon growth, identify sulfatide as a novel myelin-associated axon growth inhib

84 Thus, we have identified sulfatide as a self-lipid recognized by human iNKT cells

85 Here, we show a novel role for sulfatides as a major ligand for P-selectin in platelet

86 ost of the false positives identified by the sulfatide assay.

87 mouse CD1d in complex with cis-tetracosenoyl sulfatide at 1.9 A resolution reveals that the longer ci

88 bound CD1d is inefficient in presenting lyso-sulfatide at neutral pH, it is efficiently presented at

89 The nonhydrolyzed sulfatide-Azure A is recovered and measured at a wavelen

90 total sulfatide used in the enzyme reaction (sulfatide-Azure A present in a parallel assay performed

91 rfaces decreased the immunoreactivity toward sulfatide-beta2-glycoprotein I complex by >50% in 12 of

92 Selective sulfatide binding may indicate possible function for GSD

93 ed by site-directed mutagenesis to study its sulfatide binding properties.

94 residues within SBP that are responsible for sulfatide binding.

95 Dab2 sulfatide-binding motif contains two helices when embedd

96 e of a Dab2-derived peptide encompassing the sulfatide-binding motifs has been determined in dodecylp

97 inding peptide (SBP), contains two potential sulfatide-binding motifs represented by two consecutive

98 surface by binding to sulfatides through two sulfatide-binding motifs, modulating the extent of plate

99 region within Dab2, which we refer to as the sulfatide-binding peptide (SBP), contains two potential

100 d-binding in other proteins, suggesting that sulfatide-binding proteins share common binding mechanis

101 Both sulfatide micelles and sulfatide-binding recombinant malaria circumsporozoite p

102 son to other sulfatides or alphaGalCer, lyso-sulfatide binds with lower affinity to CD1d.

103 he role of MmpL8-mediated lipid transport in sulfatide biogenesis, we insertionally inactivated the m

104 SL-1 are coupled and that the final step in sulfatide biosynthesis may be the extra-cellular esterif

105 the integrin alpha(IIb)beta(3) receptor and sulfatides, blocking their association to fibrinogen and

106 nct mode of recognition of a self-glycolipid sulfatide bound to CD1d by a type II NKT TCR.

107 et of anti-phospholipid antibodies, bound to sulfatide-bound beta2-glycoprotein I and previous absorp

108 antibodies from 4 of 5 patients reacted with sulfatide-bound beta2-glycoprotein I.

109 s a single species of sulfatide, namely lyso-sulfatide but not other sulfatides containing additional

110 CGT-deficient mice do not synthesize GalC or sulfatide but surprisingly form myelin containing glucoc

111 Beta2-glycoprotein I binds to surface-bound sulfatides but not to other glycolipids, such as ceramid

112 In addition, sulphogalactosylceramide (sulfatide) but not heparin can induce HPC mobilization.

113 JL/J mice with a synthetic cis-tetracosenoyl sulfatide, but not alpha-galactosylceramide, reverses on

114 Sulfatide, but not galactocerebroside or ceramide, stron

115 bited the binding of laminin to bovine brain sulfatide, but not to its cell surface receptors on MCF-

116 branes immobilized with phosphoinositides or sulfatide, but not with cardiolipin.

117 Since recognition of sulfatide by CD1d-restricted T cells has now been shown

118 ibly communicating with the sulfate group of sulfatide by hydrogen bonding and/or salt bridge formati

119 binding self-glycolipid ligands such as lyso-sulfatide can be presented via the secretory and endosom

120 er a single immunodominant form of synthetic sulfatide can treat ongoing chronic and relapsing EAE in

121 Examination of potential sulfatide carrier(s) in human CSF demonstrated that sulf

122 The sulfatide/CD1d-tetramer(+) cells isolated from naive mic

123 Mice deficient in sulfatide (cerebroside sulfotransferase knock-out, CST (

124 in the myelin sheath, including ganglioside, sulfatide, cerebroside, sphingomyelin and total brain li

125 At a sulfatide coating density of 1 microg/well, beta2-glycop

126 II NKT cell TCRs, therefore, recognize CD1d-sulfatide complexes by a distinct recognition mechanism

127 sulfatide in a manner that was dependent on sulfatide concentration and incubation temperature and i

128 The increase in sulfatide concentration by a 14-mer prosaptide, TX14(A),

129 Herein prosaposin was found to increase sulfatide concentrations in primary and transformed Schw

130 posins, only saposin C was found to increase sulfatide concentrations in these cell types.

131 Sulfatides constitute a major component of myelin glycol

132 major myelin lipids galactosylceramides and sulfatides contain 2-hydroxy fatty acids.

133 lfatide, namely lyso-sulfatide but not other sulfatides containing additional acyl chains.

134 Reduced levels of binding to sulfatide-containing liposomes correlated with reduced f

135 mutant (K117A) did not interact at all with sulfatide-containing liposomes.

136 In contrast, the sulfatide content in brain tissues from human apoE4-expr

137 TX14(A) enhanced the sulfatide content of primary Schwann cells by 2.5-fold,

138 phatidylethanolamine, phosphatidic acid, and sulfatide, critical for synaptic functions.

139 Renal sulfatide-deficient mice had lower urinary pH accompanie

140 Blocking sulfatide degradation from the saposin B deficiency dimi

141 In addition to sulfatide-dependent loss of NF155, CST (-/-) x GalNAc-T

142 We found profound inhibition of sulfatide-dependent T cell proliferation which was parti

143 Sulfatide derived from the myelin stimulates a distinct

144 Assembly is characterized by coalescence of sulfatide, DG, and c-Src into a Lm-associated complex; b

145 abrogate 987P binding to the lipid receptor sulfatide did not affect the interaction with the glycop

146 Mice unable to make sulfatide did not regenerate RGC axons more robustly aft

147 metachromatic leukodystrophy, who accumulate sulfatides due to a deficiency in arylsulfatase-A, direc

148 tail of CD1b to lysosomes, failed to present sulfatide efficiently.

149 reas other lipids, such as sphingomyelin and sulfatide, either did not affect ISVP* formation or prev

150 However, mycoplasmas bound to sulfatide exhibited no gliding motility, regardless of r

151 here, the histone H1 molecules stabilize the sulfatide-fimbriae interaction by simultaneously binding

152 onance shows that the affinity of human CD1d-sulfatide for the iNKT cell receptor is relatively low c

153 ce lacking the ability to synthesize GalC or sulfatide form dysfunctional and unstable myelin.

154 is obtained by subtracting the nonhydrolyzed sulfatide from the total sulfatide used in the enzyme re

155 by dextran sulfate 500K, dextran sulfate 5K, sulfatides, fucoidan, and heparin but not by chondroitin

156 ed by decreased brain levels of cholesterol, sulfatide, galactosylceramide, and triglyceride.

157 ed sphingolipid analogs of glucosylceramide, sulfatide, ganglioside GM1, ceramide 1-phosphate, sphing

158 matrix for imaging of acidic lipids such as sulfatides, gangliosides, and phosphatidylinositols in t

159 by 3'SL was least sensitive to inhibition by sulfatide, gastric mucin, and other sulfated oligosaccha

160 R42, is responsible for interaction with the sulfatide headgroup, whereas the C-terminal polybasic re

161 Here, we demonstrate that sulfatides, highly charged anionic glycosphingolipids, a

162 H confirmed the novel role of this enzyme in sulfatide hydrolysis.

163 M. pneumoniae bound to surfaces coated with sulfatide in a manner that was dependent on sulfatide co

164 bind to sialylated receptors but adhered to sulfatide in a temperature-dependent manner.

165 eature of neuroinflammatory disease and that sulfatide in APCs may contribute to the endogenous pathw

166 lted in decreased sulfate incorporation into sulfatide in cultures of differentiating OL.

167 Over 50% of GalCer and sulfatide in myelin is hydroxylated by the integral memb

168 NK T cell hybridomas is unable to recognize sulfatide in the presence of CD1d+ antigen-presenting ce

169 cell reactivity toward these GSLs and to the sulfatides in a fashion comparable with alpha-GalCer.

170 Sulfatides in brain lipid extract were also easily detec

171 esponsible for the catabolism and control of sulfatides in humans.

172 es a first step in understanding the role of sulfatides in regulating PDGFRalpha levels in OLs and it

173 This study points to a seminal role of sulfatides in renal ammonium handling, urinary acidifica

174 ts deficiency results in the accumulation of sulfatides in the cells of the central and peripheral ne

175 nse, suggesting an immunomodulatory role for sulfatides in the pathogenesis of tuberculosis.

176 ein I also depends on the coating density of sulfatides in the well.

177 icantly able to inhibit bacterial binding to sulfatide, indicating that in addition to glycoproteins,

178 elet mixture, reduces the number and size of sulfatide-induced aggregates.

179 PD-L pathway failed to prevent bacterial- or sulfatide-induced iNKT cell anergy, suggesting additiona

180 growth inhibitor, and provide evidence that sulfatide inhibition contributes to axon regenerative fa

181 Sulfatides interact with several cell adhesion molecules

182 oposed to play an essential role in the FasG-sulfatide interaction, possibly communicating with the s

183 These results show that sulfatide interactions with P-selectin are important in

184 The sulfatide interactions with P-selectin stabilize platele

185 stricted type II NKT cell subset reactive to sulfatide involved in the regulation of autoimmunity and

186 o than was wild-type myelin, indicating that sulfatide is a major component of the inhibitory activit

187 Presentation of lyso-sulfatide is inhibited in the presence of primaquine, co

188 The hydrolyzed sulfatide is monitored upon inclusion of the colorimetri

189 Thus, ARSA activity toward the sulfatide is obtained by subtracting the nonhydrolyzed s

190 Cis-tetracosenoyl sulfatide is one of the immunodominant species in myelin

191 by neuron- or glial-specific rescue, whereas sulfatide is principally expressed and functional in gli

192 We propose that sulfatide is recognized only by human iNKT cells because

193 g of polar lipids including gangliosides and sulfatides is a necessary step in understanding the dive

194 substrate, galactosyl-3-sulfate ceramide (or sulfatide), is performed using neat sulfatide without ch

195 caused an increase in brain cholesterol and sulfatide levels in four major brain structures (hippoca

196 sterol and establish that it does not affect sulfatide levels in the brain, these levels did increase

197 g high density lipoproteins, suggesting that sulfatide levels in the central nervous system (CNS) are

198 Excess hydroxy and non-hydroxy fatty acid sulfatide levels were present in brain and kidney.

199 Galactocerebroside and sulfatide, major galactosphingolipid components of oligo

200 urons and oligodendrocytes expressing the O4 sulfatide marker.

201 The sulfatide mass in hippocampus and cortex of apoE knockou

202 e that interactions of these antibodies with sulfatides may contribute to some of the clinical sympto

203 an serve as a second-tier test following the sulfatide measurement in DBS for newborn screening of ML

204 Sulfatide-mediated activation of type II NKT cells reduc

205 cells as well as after their inactivation by sulfatide-mediated activation of type II NKT cells.

206 ecause CD1 molecules are nonpolymorphic, the sulfatide-mediated immune-regulatory pathway can be targ

207 Protection from hepatic IRI by sulfatide-mediated inactivation of type I NKT cells was

208 The mechanism involved in sulfatide-mediated inhibition may share features with ot

209 Both sulfatide micelles and sulfatide-binding recombinant mal

210 specifically recognizes a single species of sulfatide, namely lyso-sulfatide but not other sulfatide

211 i-galactolipid antibodies, showing that anti-sulfatide O4 but not anti-galactocerebroside O1 blocks t

212 he 3-hydroxyl group in the sphingoid base of sulfatides offered some protection from oxidation for th

213 In this study, the effect of sulfatides on mouse T cell function and differentiation

214 The inhibitory effect of sulfatides on T cell function was CD1d-independent and w

215 sed sulfated content of galactosylceramides (sulfatides) on the regulation of PDGFRalpha in multipote

216 glucopyranosylceramide (beta-GlcCer) but not sulfatide or phospholipids in a CD1d-dependent manner, w

217 not involved in P-selectin binding to either sulfatide or sLeX.

218 In comparison to other sulfatides or alphaGalCer, lyso-sulfatide binds with low

219 uire membrane microdomains containing either sulfatides or complex gangliosides to localize and funct

220 erse lipids such as lysophosphatidylcholine, sulfatide, or mannosyl-phosophomycoketide, but not lipop

221 f MmpL8, which transports a precursor of the sulfatides, or MmpL11, which transports an unknown subst

222 receptor-activating peptide, suggesting that sulfatide-P-selectin interactions are necessary for the

223 These results indicate that GalC and sulfatide play important roles in myelin function and st

224 Cholesterol and sulfatides play many important roles in learning and mem

225 Immunization of mice with sulfatide plus myelin peptide resulted in a more severe

226 These structure and binding data on sulfatide presentation by CD1d have important implicatio

227 iNKT cells directly recognize myelin-derived sulfatide presented by CD1d.

228 ion reactive to a myelin-derived glycolipid, sulfatide, presented by CD1d.

229 ition of type I NKT cells by retinoids or by sulfatide prevents ALD.

230 Moreover, treatment of mice with sulfatide prevents antigen-induced experimental autoimmu

231 n of sulfatide-reactive type II NKT cells by sulfatide prevents induction of EAE.

232 elitis a model for human multiple sclerosis, sulfatide-reactive T cells but not invariant NK T cells

233 kine responses, we showed that activation of sulfatide-reactive type II NKT cells and plasmacytoid DC

234 We have shown that activation of sulfatide-reactive type II NKT cells by sulfatide preven

235 Collectively, the TCR repertoire of sulfatide-reactive type II NKT cells exhibits features o

236 We have shown that the activation of sulfatide-reactive type II NKT cells leads to a signific

237 IRI: type I NKT cells promote injury whereas sulfatide-reactive type II NKT cells protect against inj

238 ophosphatidylcholine (LPC) can stimulate the sulfatide-reactive type II NKT hybridoma Hy19.3 in a CD1

239 eviously determined A'-roof positioning of a sulfatide-reactive type II NKT TCR.

240 ate fimbrial binding to a glycoprotein and a sulfatide receptor on intestinal brush borders of piglet

241 ognized by human iNKT cells and propose that sulfatide recognition by innate T cells may be an import

242 y-determining region (CDR) loops, as well as sulfatide recognition separately encoded by nongermline

243 CD patient showed decreased cerebroside and sulfatide relative to normal white matter.

244 factors, IgG anti-GQ1b:GM4, GQ1b:PS and GQ1b:Sulfatide remained associated with faster recovery.

245 The Dab2 SBP residues that interact with sulfatides resemble those described for sphingolipid-bin

246 pe II NKT cells with antibody or the agonist sulfatide, respectively.

247 ctosylceramide and galactosylsphingosine and sulfatide, respectively.

248 malization of the ratio of long versus short sulfatides, restored PDGFRalpha levels, corrected its lo

249 TCR in complex with CD1d and the self-lipid sulfatide, revealing the unusual recognition of CD1d by

250 rain lipid metabolism (e.g., accumulation of sulfatides) seen in APOE-deficient mice, indicating func

251 al structure of human CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A.

252 method to measure developmentally regulated sulfatide species (C16:0, C18:0, C24:1, and C24:0) in ce

253 ption of an analytical method to study these sulfatide species in raft and non-raft membranes and has

254 Although it is known that sulfatide species show heterogeneity in their fatty acid

255 All four sulfatide species were more abundant in raft membranes t

256 Sulfatide-specific antibodies were also detected in SJL/

257 disease course of EAE, and administration of sulfatide-specific antibody exacerbated EAE.

258 ntly presented sulfatide to CD1a-restricted, sulfatide-specific T cells.

259 sis showed lipid-specific antibodies against sulfatide, sphingomyelin and oxidized lipids in cerebros

260 was, however, a marked effect of apoE on the sulfatide (ST) content in both the brain and CSF.

261 e recently noted a profound decline in brain sulfatides (ST) in subjects who died with incipient deme

262 rest, ganglioside GM2, asialo-GM2 (GA2), and sulfatides (ST).

263 lycerol (PG), phosphatidylinositol (PI), and sulfatides (ST).

264 Sulfatide stimulation in vitro led to prominent suppress

265 Alcian blue positive (sulfatide) storage cells were found in the brain, spinal

266 y mimics that of the alkyl chain in the CD1a-sulfatide structure.

267 d blood spots (DBS) using deuterated natural sulfatide substrate.

268 95% failed to inhibit mycoplasma binding to sulfatide, suggesting that P1 does not mediate binding t

269 eramide, and the sulfated glycosphingolipids sulfatide, sulf-lactosylceramide, and sulf-globopentaosy

270 -3-sulfate-3-sulfohydrolase), which converts sulfatide (sulfogalactocerebroside) to galactocerebrosid

271 We disrupted sulfatide synthesis by a genetic approach along the enti

272 tivate ERKs, which is essential for enhanced sulfatide synthesis in Schwann cells.

273 The PACAP effect on sulfatide synthesis was fully reproduced in a cerebellar

274 lated from human cerebrospinal fluid carries sulfatide that can be captured by APCs and presented by

275 ickling may expose normally cryptic membrane sulfatides that could mediate this adhesive interaction.

276 With the exception of sulfatides, the invasion-inhibitory effect was not media

277 the platelet membrane surface by binding to sulfatides through two sulfatide-binding motifs, modulat

278 stigated presentation of the self-glycolipid sulfatide to a type II NKT cell that specifically recogn

279 ld-type CD1a molecules efficiently presented sulfatide to CD1a-restricted, sulfatide-specific T cells

280 se prevention correlates with the ability of sulfatide to suppress both interferon-gamma and interleu

281 it is not important for presentation of lyso-sulfatide to type II NKT cells.

282 possible function for GSDMB in the cellular sulfatide transport.

283 Moreover, tolerized DCs from sulfatide-treated animals can adoptively transfer protec

284 After deacylation of bovine brain sulfatide under mild alkaline conditions and reacylation

285 g the nonhydrolyzed sulfatide from the total sulfatide used in the enzyme reaction (sulfatide-Azure A

286 e Sphingomonas glycosphingolipids (GSLs) and sulfatide variants were shown to activate human NKT cell

287 ceramide-1-phosphate, glucosylceramide, and sulfatide, via the C1q domain in an oligomerization-depe

288 Myelin in which sulfatide was lacking or blocked using specific antibodi

289 binding to heparin, alpha-dystroglycan, and sulfatides was dependent upon both shared and unique con

290 that CD1d presenting self-lipids, including sulfatide, was widely recognized by gut Vdelta1+ gammade

291 lin-associated lipids galactocerebroside and sulfatide were modestly reduced in Igf1(-/-) brains.

292 Sulfatides were highly concentrated in the fetus liver,

293 ically selective images for cerebrosides and sulfatides were successfully obtained.

294 sitols, phosphatidylinositol-phosphates, and sulfatides) were scrutinized on rat brain tissue section

295 pports adhesion of cells expressing SGGLs or sulfatides, which was inhibited by monoclonal antibodies

296 Consistent with colocalization of CD1a and sulfatide, wild-type CD1a molecules efficiently presente

297 mologous series of ceramide monohexoside and sulfatide with hydroxylated fatty acyl chains ranging fr

298 First, FasG attaches strongly to sulfatide with hydroxylated fatty acyl chains.

299 en embedded in micelles, reversibly binds to sulfatides with moderate affinity, lies parallel to the

300 mide (or sulfatide), is performed using neat sulfatide without chemical modification.