ライフサイエンスコーパス: sulfo group

1 ne unit carrying either a 3-O-sulfo or a 6-O-sulfo group.

2 accharide sequence containing a critical 3-O-sulfo group.

3 ride composition and content and position of sulfo groups.

4 onic acid linked to glucosamine carrying 6-O-sulfo groups.

5 oligosaccharides with precisely located 6-O-sulfo groups.

6 acid) linked to glucosamine carrying various sulfo groups.

7 g oligosaccharides with different numbers of sulfo groups.

8 on laser irradiation, reflecting lability of sulfo groups.

9 ated, in part, with the solvolytic loss of N-sulfo groups.

10 kinetic studies showed that loss of the 3-O-sulfo group affected both the ability of the pentasaccha

11 Alexa Fluor 350, a coumarin tag containing a sulfo group, along with guanidation of epsilon-amino gro

12 ified heparins showed that the presence of N-sulfo groups and either 2- or 6-O sulfo groups were requ

13 ght or more saccharide residues with seven O-sulfo groups and four N-sulfo groups exhibited potent in

14 osamine residue of heparan sulfate can carry sulfo groups at the 2-N, 3-O, and 6-O positions, leading

15 Moreover, we showed that one of the three sulfo groups can be easily substituted with S-, N-, and

16 strength and pH showed that loss of the 3-O-sulfo group caused a massive approximately 60% loss in b

17 esults in up-regulation of 2-O-, 6-O-, and N-sulfo group-containing disaccharides, further emphasizin

18 ides and resistant tetrasaccharides with 3-O-sulfo group-containing glucosamine residues at their red

19 The content of 3-O-sulfo group-containing tetrasaccharides in a heparin cor

20 block copolymers containing S-domains (high sulfo group content) placed adjacent to N-domains (low s

21 p content) placed adjacent to N-domains (low sulfo group content) were chemoenzymatically synthesized

22 esidues with seven O-sulfo groups and four N-sulfo groups exhibited potent inhibition.

23 2-O-sulfotransferase (HS-2OST) transfers the sulfo group from 3'-phosphoadenosine 5'-phosphosulfate (

24 These findings demonstrate that the 3-O-sulfo group functions as a key determinant of heparin pe

25 luor 350, a coumarin derivative containing a sulfo group (i.e., bearing strong negative charge), show

26 To elucidate the role of the 3-O-sulfo group in the activation mechanism, we compared the

27 that a modest increase in the content of 3-O-sulfo groups in BIH increases the number of antithrombin

28 ethod for controlling the positioning of 6-O-sulfo groups in oligosaccharides.

29 determination of chain length and number of sulfo groups in the intact GAGs.

30 This sulfo group interacts with the guanidinium group of Arg1

31 350, and Arg-190 of 2OST interact with the N-sulfo groups near the modification site, consistent with

32 The location of the sulfo group of S-pyr is postulated to mimic the phosphon

33 to proceed through hydride transfer and the sulfo group of the oxidized and reduced molybdenum cente

34 ronic acid monosaccharides or the N- and 6-O-sulfo groups of the glucosamine sulfate monosaccharides.

35 ys-146, and Arg-147 from apoE and N- and 6-O-sulfo groups of the glucosamine units from the heparin f

36 dues make direct contact with either the 2-O-sulfo groups of the iduronic acid monosaccharides or the

37 drogen bonding distances to the carboxyl and sulfo groups of the uronic acid unit.

38 (o) The enhancement of enzyme affinity by a sulfo group on C-6 of Gal was demonstrated by an increas

39 In contrast, 6-O-sulfo groups on HS are likely excluded by steric and ele

40 This requirement for the N-acetyl or N-sulfo groups on the glucosamine substrate can be explain

41 we compared the effects of deleting the 3-O-sulfo group or mutating the Lys(114) binding partner of

42 the detection and localization of the lost N-sulfo groups, potentially providing valuable insights in

43 ementary to heparan sulfate rich in N- and O-sulfo groups such as that found in the liver and the bra

44 s finding showed that LGS1 in sorghum uses a sulfo group to catalyze leaving of a hydroxyl group and

45 O-sulfotransferase (2OST) that transfers the sulfo group to the 2-OH position of iduronic acid (IdoA)

46 HS 2-O-sulfotransferase (2OST) transfers the sulfo group to the 2-OH-position of glucuronic or iduron

47 ferase (3-OST) is an enzyme that transfers a sulfo group to the 3-OH position of a glucosamine unit.

48 2-O-sulfotransferase (CS-2OST) transfers the sulfo group to the hexauronic acid that is adjacent to N

49 nclude that mutant 3-OST-6 fails to transfer sulfo groups to the 3-OH position of HS, resulting in in

50 The product ions resulting from the sulfo-group transfers were characterized by MS(3) experi

51 sence of N-sulfo groups and either 2- or 6-O sulfo groups were required for inhibition of toxicity.

52 Sulfo groups were transferred from adenosine 3'-phosphat