ライフサイエンスコーパス: sulfonamide

1 ch we refer to as SPLAMs (splicing inhibitor sulfonamides).

2 tional mechanism of the ion transport by bis(sulfonamides).

3 nating in biomass (macrolides) and effluent (sulfonamides).

4 ha-acetoxy ketones in the case of absence of sulfonamide.

5 peting reduction of the azide substrate to a sulfonamide.

6 B yielded an additional oxidized adduct, the sulfonamide.

7 ty over hNaV1.5 comparable to the heteroaryl sulfonamide.

8 ersion of secondary and tertiary alcohols to sulfonamides.

9 2) C-H bonds with pyrazoles, imidazoles, and sulfonamides.

10 try, and provide attractive bioisosteres for sulfonamides.

11 ical internal alkenes as well as substituted sulfonamides.

12 terionic/cationic polyfluoroalkyl amides and sulfonamides.

13 rotelomer carboxylates and n:2-fluorotelomer sulfonamides.

14 rearrangement involving aryl and heteroaryl sulfonamides.

15 nation was observed for carboxylic acids and sulfonamides.

16 f only two described natural product primary sulfonamides.

17 g better yields than more encumbered N-alkyl sulfonamides.

18 ible with our reaction conditions as well as sulfonamides.

19 tereoselectively construct 5-membered cyclic sulfonamides.

20 a screen revealed sulfolane 1 and indoline-5-sulfonamides 2 and 3 as potent inhibitors of mycobacteri

21 5,9b-te-trahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (2,3,5,6TMP-TQS), previously published as a

22 n-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide (25) was identified as the lead compound in

23 coupling of the penultimate core acid 2 with sulfonamide 3 furnishes drug substance 1 with consistent

24 %), vancomycin (4/25, 16.0%), and antibiotic sulfonamides (4/25, 16.0%).

25 iler chicken isolates, followed by sul1 (for sulfonamide; 44.16%), aadA1 (for streptomycin; 33.50%),

26 antimicrobials, the most commonly used were sulfonamides (75%) and streptomycin (54%).

27 f two largely employed antibiotics families: sulfonamides (9 SDs) and fluoroquinolones (6 FQs).

28 Perfluorohexane sulfonamide, a potential transformation product of sulfo

29 eFOSE and N-EtFOSE); and two perfluorooctane sulfonamide acetic acids (N-MeFOSAA and EtFOSAA).

30 Aryl sulfonamides add to benzyne upon fluoride activation, an

31 g esters, aryl halides, aryl boronic esters, sulfonamides, alkyl tosylates, and alkyl bromides.

32 nium sulfoxide (FTSHA-SO), 6:2 fluorotelomer sulfonamide alkylamine (FTAA) and C3 to C6 perfluoroalka

33 The sulfonamide alkylation partner appears to be only limite

34 rotelomer sulfonamide (FTSAm), fluorotelomer sulfonamide alkylbetaines (FTABs), fluorotelomer betaine

35 ic acids, phenols, thiophenol, and secondary sulfonamide also provide the desired products of esters,

36 for tetracyclines, macrolides-lincosamides, sulfonamides, aminoglycosides, and beta-lactams were qua

37 ation strategy that primarily focused on the sulfonamide and benzamide appendages of the scaffold.

38 on and borylation of anthraquinones to the o-sulfonamide and m-borylated products has been developed.

39 donors: KPC-2 is preferentially inhibited by sulfonamide and tetrazole-based derivatives, NDM-1 by co

40 differentiated from each other and also from sulfonamides and aliphatic carboxylic acids based on rea

41 Primary sulfonamides and amides can be protected in moderate to

42 ises the possibility that inhibition by aryl sulfonamides and by classic local anesthetics might show

43 ith dihydropteroate synthase (DHPS), such as sulfonamides and p-aminosalicylic acid (PAS), we hypothe

44 In contrast, sterically hindered bis-sulfonamides and related nucleophiles reacted with BCB-B

45 Simple sulfonamides and sulfamates can be used directly in the

46 sulfonyl fluorides can be converted to aryl sulfonamides and sulfonic esters using Cs2CO3 under mild

47 eous adverse drug reaction compared with non-sulfonamides and that medicinal chemists should not avoi

48 To monitor the levels of sulfonamides and their metabolites in farms in Lebanon,

49 nd C(8) perfluorosulfonates, perfluorooctane sulfonamide, and 6:2 and 8:2 fluorotelomer sulfonates).

50 tane sulfonamidoacetic acid, perfluorooctane sulfonamide, and PFOS.

51 this work, we explored the amide, carbamate, sulfonamide, and urea derivatives of prop-2-ynylidenecyc

52 gh-risk" drugs such as antiepileptic agents, sulfonamides, and antiretroviral drugs accounted for the

53 glycosides, tetracyclines, fluoroquinolones, sulfonamides, and chloramphenicol) and limited-efficacy

54 cies, nucleobases, nucleosides, nucleotides, sulfonamides, and cyclic peptides among other highly pol

55 to the functionalization of primary amides, sulfonamides, and other N-functional groups that typical

56 acids (e.g., carboxylic acid based polymers, sulfonamides, anionic polysaccharides, and anionic polyp

57 Sulfapyridine (SPy) is a sulfonamide antibiotic largely employed as veterinary dr

58 dition, the photosensitized oxidation of the sulfonamide antibiotic sulfadiazine (SDZ) was studied.

59 sotalol (a beta-blocker) and sulfadiazine (a sulfonamide antibiotic) exhibited a marked photosensitiz

60 m of sulfamethoxazole (SMX), a commonly used sulfonamide antibiotic, by Arabidopsis thaliana.

61 ted approach for the facile integration of a sulfonamide antibiotic-sensing layer with SAW technology

62 this population were to penicillins (12.8%), sulfonamide antibiotics (7.4%), opiates (6.8%), and nons

63 BZ), naproxen (NAP), trimethoprim (TMP), and sulfonamide antibiotics (SAs)) in synthetic hydrolyzed h

64 uced transformation of selected anilines and sulfonamide antibiotics were determined by competition k

65 m "sulfa allergy", originally coined for the sulfonamide antibiotics, has become associated with any

66 for a human blood factor in the activity of sulfonamide antibiotics.

67 ontaining backbone to enable construction of sulfonamide antisense oligonucleotides (SaASOs).

68 n was therefore selected to access aliphatic sulfonamides, applying a single-step hydrosulfamoylation

69 tion of such a molecule - an AminoPYrimidine-Sulfonamide (APYS1) that has potent, bactericidal activi

70 visible-light photoredox catalysis, primary sulfonamides are coupled with electron-deficient alkenes

71 to the N-O bond of N-(pentafluoro-benzoyloxy)sulfonamides are described.

72 cluding tetracyclines, fluoroquinolones, and sulfonamides are effective for plague treatment, althoug

73 Sulfonamides are key motifs in pharmaceuticals and agroc

74 Sulfonamides are known not only to be antimicrobial drug

75 Sulfonamides are pervasive in pharmaceuticals and agroch

76 such as fluoroquinolones, tetracyclines, and sulfonamides are potentially safer but lack robust human

77 mpound 1 by replacing the carboxylate with a sulfonamide as in 50.

78 st time a novel series of tellurides bearing sulfonamide as selective and potent inhibitors of the be

79 d optimization of a novel class of tricyclic sulfonamides as allosteric GlyR potentiators.

80 We discovered a novel series of aryl sulfonamides as CNS-penetrant, isoform-selective Na(V)1.

81 Here we show bis(sulfonamides) as efficient receptors for selective Cl(-)

82 nto sodium sulfonates, sulfonate esters, and sulfonamides, as well as styrenes by Julia-type olefinat

83 designed and synthesized a total of 32 beta-sulfonamide Asp analogues and characterized their pharma

84 n small structural differences in these beta-sulfonamide Asp analogues provide analogues with diverse

85 s of antimicrobial drug ions (quinolones and sulfonamides) at a water/oil interface.

86 enzyme overexpressed in hypoxic tumors, with sulfonamide-based imaging agents.

87 amide, a potential transformation product of sulfonamide-based PFASs, was present at high concentrati

88 Fluorotelomer- and perfluoroalkyl sulfonamide-based polyfluorinated compounds were transfo

89 E) reporter assays, we identified a bis-aryl sulfonamide bearing compound 1 that demonstrated sustain

90 namide headgroup have emerged, with the acyl sulfonamide bestowing levels of selectivity over hNaV1.5

91 Notably, fluorotelomer sulfonamide betaines (8:2-FTAB and 10:2-FTAB), fluorotel

92 of the structures revealed that the mode of sulfonamide binding correlates well with their inhibitor

93 aries bearing combinations of modifications (sulfonamide, biotin, mannose) against matched targets (c

94 Structural restriction of the sulfonamide bond was used to design sultams with abnorma

95 Once assembled, the synthesis of a sulfonamide by reacting 4-chlorobenzenesulfonyl chloride

96 identified a nanomolar potent PEGylated bis-sulfonamide CA inhibitor (25) able to significantly redu

97 ss-dehydrogenative coupling of indoline with sulfonamides, carboxamides, and anilines is reported.

98 the desymmetrized product using the complete sulfonamide catalyst I.

99 chalcone scaffold and cLogP increase in the sulfonamide chain improved potency.

100 antibiotic (eg, nitrofurantoin, trimethoprim/sulfonamides, ciprofloxacin) in the 30 days after the as

101 of inhibition of Nav1.7 channels by the aryl sulfonamide compound PF-05089771, consistent with state-

102 uinolinone sulfonamide inhibitors [ Bicyclic sulfonamide compounds as sodium channel inhibitors and t

103 We characterized 2 novel sulfonamide compounds identified in the screen.

104 ,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide), consistent with AA site involvement.

105 t of the phosphodiester backbone of RNA by a sulfonamide-containing backbone to enable construction o

106 These results strongly suggest that sulfonamide-containing compounds are not at a higher ris

107 tion: should medicinal chemists avoid making sulfonamide-containing compounds in drug discovery progr

108 Analogues of the sulfonamide-containing COX-2 inhibitor Celecoxib were pr

109 n protocol generates molecules as complex as sulfonamide-containing cyclobutyl-spirooxindoles for dir

110 -containing DNA-RNA hybrid than that for the sulfonamide-containing DNA-DNA hybrid.

111 (T(m)) of both hybrids, it was lower for the sulfonamide-containing DNA-RNA hybrid than that for the

112 On the basis of the prevalence of sulfonamide-containing drugs and building blocks, we hav

113 seawater, where according to the literature sulfonamides content is minimum compared with other envi

114 nt GLO1 inhibitor was developed with a novel sulfonamide core pharmacophore.

115 The crystalline sulfonamides could be further elaborated by alkylation a

116 Aliphatic carboxylic acids and sulfonamides could not be differentiated from each other

117 The sulfonamides could withstand conditions that functionali

118 n and reductive elimination with a series of sulfonamide derivatives are in good agreement with exper

119 (SAR) studies carried out to identify novel sulfonamide derivatives as potent, selective, and state-

120 the preformation of ammonium, pyridinium, or sulfonamide derivatives from the corresponding alkyl ami

121 In particular, sulfonamide derivatives of cinchona alkaloids are highly

122 carboxylation of 8-aminoquinoline amide and sulfonamide derivatives.

123 N-(3-Phenylprop-2-yn-1-yl)-sulfonamides derived from serine and threonine were synt

124 te nanoparticles for specific and label-free sulfonamide detection is reported.

125 timizing HIV-1 PIs containing bis-THF in non-sulfonamide dipeptide isosteres.

126 Indisulam is an aryl sulfonamide drug with selective anticancer activity.

127 e selected a series of positional isomers of sulfonamide drugs that were analyzed in positive and neg

128 mutant AML that can be targeted by existing sulfonamide drugs.

129 , the PFOS-precursor N-ethyl perfluorooctane sulfonamide (EtFOSA) is used in Sulfluramid, a pesticide

130 N-MeFOSA, and N-EtFOSA); two perfluorooctane sulfonamide ethanols (N-MeFOSE and N-EtFOSE); and two pe

131 ahydropyridin-1-yl]ethyl}-3-methylb enzene-1-sulfonamide) exhibited a broad antipsychotic-, antidepre

132 sulfonates (FTSs), nonionic perfluoroalkane sulfonamides (FASAs), cyclic PFAS (PFEtCHxS), per- and p

133 dy, the PFAS alternative, perfluoro-1-butane-sulfonamide (FBSA), was identified for the first time in

134 studies of a previously disclosed nonacidic sulfonamide FFA4 agonist.

135 The PFASs detected included perfluorohexane sulfonamide (FHxSA), 6:2 fluorotelomer sulfonamide (FTSA

136 from 6 classes (beta-lactams, tetracyclines, sulfonamides, fluoroquinolones, macrolides, and coccidio

137 e to fluoroquinolones (cdeA and gyrA) and to sulfonamides (folP) were the most frequent in the analyz

138 synthesized six new carboxamides and 24 new sulfonamides for a detailed structure-activity relations

139 hile transformation products perfluorooctane sulfonamide (FOSA) and PFOS are sufficiently mobile to l

140 and three products including perfluorooctane sulfonamide (FOSA) for PFOSAmS through high-resolution m

141 acids (PFCAs, C(4-13)), and perfluorooctane sulfonamide (FOSA) were analyzed in plasma (n = 128) fro

142 uorooctane sulfonate (PFOS), perfluorooctane sulfonamide (FOSA), and C8-C14 perfluoroalkyl carboxylat

143 gnificant temporal trends of perfluorooctane sulfonamide (FOSA), perfluorooctane sulfonate (PFOS), an

144 s for any substances, except perfluorooctane sulfonamide (FOSA).

145 tant intermediate precursor (perfluorooctane sulfonamide: FOSA), into a prevalent compound in most wi

146 uorotelomer alcohols (FTOHs), perfluorooctyl sulfonamides (FOSAs), and sulfonamidoethanols (FOSEs), w

147 fonamidoethanols (FOSEs), and perfluoroalkyl sulfonamides (FOSAs), were assessed in 61 residential in

148 ocol for the direct formation of substituted sulfonamides from sulfonyl azides and amines via nucleop

149 exane sulfonamide (FHxSA), 6:2 fluorotelomer sulfonamide (FTSAm), fluorotelomer sulfonamide alkylbeta

150 ytes with a carboxylic acid, a sulfone, or a sulfonamide functionality formed diagnostic adducts that

151 ,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (GAT107) and 3-(3,4-difluorophenyl)-N-(1-(6-

152 Sulfonamides generally showed higher inhibition compared

153 improvement compared with the control ligand sulfonamide-GGGG.

154 e two phenyl rings and amide nitrogen of the sulfonamide group of compound 1 focused toward identific

155 f cutaneous AEs for drugs with and without a sulfonamide group was conducted.

156 ds via the protonation of oxygen atom of the sulfonamide group.

157 dicinal chemists should not avoid use of the sulfonamide group.

158 the electronic effects of ether, ester, and sulfonamide groups in the homoallylic position.

159 Glutathione sulfonamide (GSA), a HOCl-specific product, was also for

160 istant mutants generated against an indazole sulfonamide (GSK3011724A) identifies several specific si

161 ng affinity resulting from modulation of the sulfonamide H-bond donor strength.

162 Structurally related chiral sulfonamide has shown great potential in drug molecules

163 Reduction of a range of benzo-fused cyclic sulfonamides has been accomplished using low-valent tita

164 fficient manganese-catalyzed N-alkylation of sulfonamides has been developed.

165 the medicinal chemistry pedigree of primary sulfonamides has dominated for several decades.

166 phaCA with a family of acetazolamide-related sulfonamides have been determined.

167 acophoric features that include a heteroaryl sulfonamide headgroup and a lipophilic aromatic tail gro

168 atic tail groups in combination with an acyl sulfonamide headgroup have emerged, with the acyl sulfon

169 Potency optimization of the sulfonamide hit compounds was undertaken as informed by

170 A biaryl acyl sulfonamide hit from this library was elaborated, optimi

171 In contrast to conventional troublesome sulfonamide hydrolysis, a near-stoichiometric amount of

172 ith the Cr catalyst prepared from the chiral sulfonamide identified via the toolbox approach.

173 derived by lead optimization of the benzene-sulfonamide in silico hit compound 3.

174 The reactivity of sulfonamides in comparison to trifluoroacetamide is comp

175 BIN analogs as well as axially chiral N-aryl sulfonamides in excellent enantiopurity.

176 cing functionalized 5-membered chiral cyclic sulfonamides in high yields with high enantioselectiviti

177 titative screening of 12 different regulated sulfonamides in honey.

178 (beta-lactams, tetracyclines, quinolones and sulfonamides) in milk within 20 min.

179 h the folate pathway, as other antimicrobial sulfonamides; indeed, the sulfonamide portion of the com

180 is the first time a natural product primary sulfonamide inhibitor has been assessed for inhibition a

181 ion of a series of atropisomeric quinolinone sulfonamide inhibitors [ Bicyclic sulfonamide compounds

182 e cancer, obesity, epilepsy, glaucoma, etc., sulfonamide inhibitors as those reported here may be of

183 n HCAII that stabilizes the apolar moiety of sulfonamide inhibitors is replaced with a more open, hyd

184 Sulfonamide inhibitors of HpalphaCA possess anti-H. pylo

185 offer ADME advantages over known heteroaryl sulfonamide inhibitors.

186 When the sulfonamide is unprotected, the characteristic ring-open

187 lity to discriminate among various different sulfonamides is demonstrated.

188 ived nonaflates with amides, carbamates, and sulfonamides is described.

189 The negative perception of sulfonamides is not supported by any systematic study or

190 ntramolecular hydroamination of alkenes with sulfonamides is reported.

191 the multidimensional LCxDMS-MS separation of sulfonamide isomers in human plasma.

192 hane (Crwn-THF), a P2'-methoxybenzene, and a sulfonamide isostere, is highly active against laborator

193 )-N, N-bis(pyridin-2-ylmethyl) naphthalene-1-sulfonamide (L).

194 c system followed by thiazole replacement on sulfonamide led to identification of lead molecules with

195 was explored through preparation of a crude sulfonamide library and evaluation of the library in a B

196 nanticipated oxygen-nitrogen exchange of the sulfonamide ligand prior to an inner-sphere SN2-type red

197 ized Cr-reagent, prepared from CrCl(2) and a sulfonamide ligand, allows one to perform the coupling w

198 ))-N bond-forming reductive elimination from sulfonamide-ligated Pd(IV) complexes.

199 The sulfonamide linker is critical to activity, substitution

200 ocaine and the external binding site of aryl sulfonamides may have synergistic actions.

201 1) and K2P10.1 (TREK-2) activators-an N-aryl-sulfonamide, ML335, and a thiophene-carboxamide, ML402-d

202 Although sulfonamide modification caused a decrease in melting te

203 ferroptosis inhibitors containing amide and sulfonamide moieties with improved stability, single dig

204 nce of association between the presence of a sulfonamide moiety and a high reporting rate of cutaneou

205 f 0.48); however, the reparametrization of a sulfonamide moiety improved the agreement with experimen

206 The properties of a sulfonamide moiety replacement were evaluated by incorpo

207 ome associated with any drugs that contain a sulfonamide moiety.

208 position of the d-glucosamine unit with the sulfonamide motif effectively inhibited the Sulf-1 activ

209 dyl radical intermediates formed from native sulfonamide N-H bonds leading to 1,4-cyclohexadiene-fuse

210 upled electron transfer (PCET) activation of sulfonamide N-H bonds.

211 a logical correlation between the acidity of sulfonamide N-H proton and binding strength.

212 to the pyrimidine nitrogen and (2) from the sulfonamide N-H to the gatekeeper threonine.

213 Among those treated with a sulfonamide (n = 322 [42%]), tetracycline (n = 171 [22%]

214 on NS5B inhibitors including GSK8175 (49), a sulfonamide- N-benzoxaborole analog with low in vivo cle

215 PF-05089771 is an aryl sulfonamide Nav1.7 channel blocker that binds to the ina

216 Such aryl sulfonamide Nav1.7 channel blockers bind to the extracel

217 in the transition state, especially when the sulfonamide NH is deprotonated, drastically raises the a

218 The inhibitory function of sulfonamides on CA was discovered some 80 years ago.

219 5,9b-te-trahydro-3H-cyclopenta[c]quinoline-8-sulfonamide, originally reported to lack activity when u

220 omer sulfonates (FTS); three perfluorooctane sulfonamides (PFOSA, N-MeFOSA, and N-EtFOSA); two perflu

221 ther antimicrobial sulfonamides; indeed, the sulfonamide portion of the compound is not needed for ac

222 This work highlights the importance of sulfonamide precursors in contributing to bioaccumulatio

223 serum, suggesting in vivo transformation of sulfonamide precursors.

224 ation and enables facile deprotection of the sulfonamide products with thioglycolic acid.

225 only limited by sterics, with unsubstituted sulfonamides providing better yields than more encumbere

226 The natural product primary sulfonamide, psammaplin C (1), when used in combination

227 Based on analysis of tertiary aliphatic sulfonamides published in the Cambridge crystallographic

228 The biotransformation of perfluorooctane sulfonamide quaternary ammonium salt (PFOSAmS) was very

229 Some of the sulfonamides reported here showed significant intraocula

230 The biaryl acyl sulfonamides reported herein may also offer ADME advanta

231 Sulfonamide represents the most reactive activating grou

232 m agents and showed that modification of the sulfonamide residue bears future optimization potential.

233 of linkers and substituents attached to the sulfonamide residue.

234 Sulfonamide residues could be detected in forty-six samp

235 for the first time, for the determination of sulfonamides residues in milk using a highly polar sol-g

236 moxazole led to an increase in macrolide and sulfonamide resistance determinants.

237 of Escherichia coli and its plasmid-encoded sulfonamide resistance gene sul1 in different water matr

238 or amide group of deprotonated quinolone or sulfonamide, respectively, may play a dominant role in s

239 les then allows conversion into sulfones and sulfonamides, respectively, in a one-pot, two-step proce

240 As monoaza analogues of sulfones and sulfonamides, respectively, they combine good physicoche

241 It was shown that by employing these sulfonamide RNA (SaRNA) monomers, it was possible to syn

242 The residues of the four sulfonamides (SAs) were analyzed by extraction process a

243 y high-throughput screening, we identified a sulfonamide scaffold that served as a pharmacophore to g

244 ructure-activity relationship of the benzene-sulfonamide scaffold that yielded a series of highly pot

245 ivity relationship (SAR) of the quinolinol-5-sulfonamide scaffold was explored through preparation of

246 The design of three dual-tailed sulfonamide series 11a-11g, 14a-14h, and 16a-16e as carb

247 a fragment hit with the previously reported sulfonamide series.

248 ulfonamides, tasisulam and chloroquinoxaline sulfonamide, share the same mechanism of action as indis

249 Most of the prepared sulfonamides showed low inhibition against hCA I isoform

250 ound, which was higher than for any existing sulfonamides studied.

251 sin and discovered that derivatives with N8'-sulfonamide substitution exhibit up to a 10-fold increas

252 f the reaction is very broad with respect to sulfonamide substrate, but the position and electronic n

253 nion-binding and transport activity of a bis(sulfonamide) system are far superior compared to those o

254 of novel gallium-radiolabeled small-molecule sulfonamides targeting CA IX.

255 Two other clinically tested sulfonamides, tasisulam and chloroquinoxaline sulfonamid

256 sed strategy is base-mediated cyclization of sulfonamide-tethered 5-iodo-1,2,3-triazoles which are re

257 A series of acidic diaryl ether heterocyclic sulfonamides that are potent and subtype selective NaV1.

258 eport the optimization of a series of phenyl sulfonamides that exhibit a novel mode of binding to non

259 -H bonds over reduction of the azides to the sulfonamides that is higher and with substrate scope tha

260 an additional, alternative binding site for sulfonamides that is not present in HCAII.

261 a-lactam drugs and the other containing both sulfonamides, three aminoglycosides, and tetracycline.

262 blocks, we have developed a method to enable sulfonamides to be applied as versatile synthetic handle

263 lecular cascade cyclization of homopropargyl sulfonamides to generate a highly reactive dihydropyrrol

264 ethod to reductively cleave the N-S bonds of sulfonamides to generate sulfinates and amines, componen

265 The binding of sulfonamides to human carbonic anhydrase II (hCAII) is a

266 tion/1,6-conjugate addition of homopropargyl sulfonamides to p-quinone methides to access diverse dia

267 r the mild, late-stage conversion of primary sulfonamides to several other other functional groups.

268 s occur via initial reductive deamination of sulfonamides to sulfinates via an NHC-catalyzed reaction

269 ng from the sp(3)-hybrid lone pair in common sulfonamides to the sp-like lone pair in the smallest Pa

270 1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide (TQS) and the alpha7 ago-PAM 4BP-TQS.

271 ing from the previously reported pyrrolidine sulfonamide TRPV4 inhibitors 1 and 2.

272 N,N-Dibromo-p-toluene sulfonamide (TsNBr2) has been found to be an effective r

273 spectrometry confirmed the presence of three sulfonamides, two fluorotelomer sulfonates, and several

274 gh the reaction between terminal alkynes and sulfonamides under ambient air using PIDA (diacetoxy iod

275 A diverse range of aryl and alkyl sulfonamides undergoes mono- N-alkylation in excellent i

276 triad, as well as mild electrophiles such as sulfonamide, urea, and carbamate.

277 e a multiday S(N)Ar arylation of a secondary sulfonamide using HMPA as solvent, multiple functional g

278 erationally simple catalytic N-alkylation of sulfonamides using commercially available chiral amine c

279 clines, chloramphenicol, aminoglycosides, or sulfonamides was 1.3%, 1.4%, 7.5%, and 20.2%, respective

280 Late-stage cleavage of protecting sulfonamides was addressed using reductive N-S cleavage

281 A series of tertiary aliphatic sulfonamides was studied by crystallographic and quantum

282 et testing limit of 10 ng/g in honey for the sulfonamides was used based upon action limits set for o

283 al late-stage functionalization of secondary sulfonamides, we have developed a mild and general metho

284 1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide were also linear and showed no calcium-depen

285 These sulfonamides were also found effective upon oral adminis

286 beta-lactams, tetracyclines, quinolones and sulfonamides were determined to be 8 ng/mL, 2 ng/mL, 4 n

287 ohols, phenols, carboxylic acids, thiols and sulfonamides were found to be competent nucleophiles, pr

288 The synthesized primary and secondary sulfonamides were investigated as inhibitors of six phys

289 oarylated alpha-branched benzyl sulfones and sulfonamides were obtained in good yields, and overaryla

290 A series of aromatic/heterocyclic bis-sulfonamides were synthesized from three established ami

291 edict relative reaction rates with different sulfonamides, which is successful only after considering

292 s of esters, ethers, thioether, and tertiary sulfonamide with 43-93% yields.

293 Negishi-type alpha-arylation of sulfones and sulfonamides with a broad range of aryl bromides has bee

294 ligomeric or polymeric diamines to yield bis-sulfonamides with short or long (polymeric) linkers.

295 An intermolecular alkylation of sulfonamides with trichloroacetimidates is reported.

296 Chemoselective acidic hydrolysis of sulfonamides with trifluoromethanesulfonic acid has been

297 ng/mL for quinolones, and 0.1-3.98 ng/mL for sulfonamides, with linear correlation coefficients highe

298 ubstituted internal alkenes with substituted sulfonamides without having directing group is demonstra

299 carbonic anhydrase yielded a potent ligand, sulfonamide-WIVP, with Kd = 6.7 +/- 2.1 nM, a 20-fold im

300 Both aliphatic carboxylic acids and sulfonamides yield several fragment ions in these MS(4)