ライフサイエンスコーパス: sulfone

1 of the synthetic homopolymer poly(propylene sulfone).

2 addition to tosylacetylene (ethynyl p-tolyl sulfone).

3 n sulfoxide, terbufos sulfone and disulfoton sulfone).

4 eferentially to the anti-N-benzylpyrrolidine sulfone.

5 e location of the olefin with respect to the sulfone.

6 bsequent S-oxidation gives the corresponding sulfone.

7 tion process of a N-Boc-protected piperidine sulfone.

8 o works with metabisulfite for the source of sulfone.

9 ide, allyl methyl sulfoxide and allyl methyl sulfone.

10 ons of an appropriately functionalized vinyl sulfone.

11 via isomerization to an electrophilic vinyl sulfone.

12 lfones and their ensuing reaction with allyl sulfones.

13 cetylenes, and easy access to arylacetylenic sulfones.

14 is crucial to the rate for the bispropargyl sulfones.

15 by ring expansion to generate novel bicyclic sulfones.

16 zation of bispropargyl substrates other than sulfones.

17 t one-pot synthesis of alpha-alkyl-beta-keto sulfones.

18 -substituted internal alkynes from propargyl sulfones.

19 d with periodate to give their corresponding sulfones.

20 y of two new reaction modes of epoxides with sulfones.

21 yl-alpha-amino acids to 1-(N-acylamino)alkyl sulfones.

22 es access to various alpha-substituted vinyl sulfones.

23 nd enals for the synthesis of functionalized sulfones.

24 properties never observed for the respective sulfones.

25 g oxygen atom of the keto group of beta-keto sulfones.

26 zed conjugate addition of aldehydes to vinyl sulfones.

27 electivity, proving superior to phenyl vinyl sulfone 1 and with clear advantages over bis-sulfone 2.

28 lity of 6-(aryl)methylidene penicillin-based sulfones 1-7 to repurpose beta-lactam antibiotics activi

29 lly prevalent picolyl amides with an allenyl sulfone, 1-methyl-4-(propa-1,2-dien-1-ylsulfonyl)benzene

30 Sulfone 10b had salmeterol-like potency and selectivity

31 y with regard to hERG activity, led to alkyl sulfone 16.

32 sulfone 1 and with clear advantages over bis-sulfone 2.

33 hyde (1) and ethyl 1-phenyl-1H-tetrazol-5-yl sulfone (2), considered a paradigmatic example of the re

34 Heteroaryl vinyl sulfone 3 presented excellent output in terms of reactiv

35 The easily available vinyl sulfone 3 showed great potential for new applications in

36 Oxidation of 30 to sulfone 31 and phosphonate hydrolysis completed the synt

37 ied PHE-OPs (3.0%), DBT and dibenzothiophene sulfone (4.9%), PYR and 3 quantified PYR-OPs (3.1%), and

38 o-Phe-Leu-Leu-4-aminomethyl-Phe-methyl vinyl sulfone (4a, LU-102), and a fluorescent activity-based p

39 ega)-heptaprenol, 4] using the nerol-derived sulfone 8 as the key intermediate.

40 Sulfone 8 is prepared by the literature route and is con

41 tion of this novel series delivered thiazole sulfone 93, which was able to disrupt the GK-GKRP intera

42 On the other hand, diallyl sulfone, a known metabolite of diallyl monosulfide, alky

43 enolates with beta,beta-difluorovinyl phenyl sulfone, a new (1'-fluoro)vinyl cation equivalent, and a

44 A vinyl sulfone acceptor olefin was developed, which allowed for

45 nt evidence that rigosertib, a styryl-benzyl sulfone, acts as a RAS-mimetic and interacts with the RB

46 which allowed for the efficient synthesis of sulfone adducts that could be used as branch points for

47 oxycarbonyl alaninal and chloromethyl phenyl sulfone afforded chlorohydrins, which were converted int

48 n of 2-hydroxybenzaldehydes and 2-bromoallyl sulfones afforded 2H- and 4H-chromenol derivatives endow

49 The use of 1-(tert-butyl)tetrazolyl sulfone affords the construction of the Z-trisubstituted

50 ylation with an iodomethylphenyl sulfide and sulfone-aldehyde coupling/reductive desulfurization sequ

51 Key controlling aspects in the sulfone alkylation/oxidative desulfurization to join the

52 alpha-Sulfone-alpha-piperidine and alpha-tetrahydropyranyl hyd

53 f the sulfonamide) led to the discovery that sulfones also serve as useful directing groups for asymm

54 observed, such as olefins possessing esters, sulfone, amide, cyanide, and ketones, aromatic residues

55 he selectivity of unsymmetrical bispropargyl sulfones, amines, methanes, and sulfides.

56 ate anion-mediated activation of the allenyl sulfone analogous to phosphine-triggered reactions.

57 revealed moderate levels of activity for the sulfone analogue of hydrocodone.

58 as-phase ion/molecule reaction of protonated sulfone analytes with trimethyl borate (TMB) that yields

59 ion products (disulfoton sulfoxide, terbufos sulfone and disulfoton sulfone).

60 a chemical modification to the corresponding sulfone and ether derivatives.

61 n' aroma, while dimethyl sulfoxide, dimethyl sulfone and ethyl methyl sulfone were responsible for 's

62 h involves methylation of a pro-A ring vinyl sulfone and in situ traping of the allyl sulfonyl anion

63 y optimization by incorporation of P1' alkyl sulfone and P2 methyl groups provided a macrocycle with

64 The synthesis of vinyl sulfones and (alpha,beta-unsaturated) nitriles from carb

65 their reactions with beta-substituted vinyl sulfones and alpha,beta-unsaturated esters.

66 In summary, sulfones and aromatic carboxylic acids can be differenti

67 ctive compounds, such as keto-esters or keto-sulfones and cyclic or acyclic diketones, afforded more

68 otherwise difficult to obtain alkyl alkynyl sulfones and cyclic vinyl sulfones via 1,2-rearrangement

69 ization in two systems, namely bis-propargyl sulfones and ethers.

70 nes, hypervalent alkynyliodoniums, acetylene sulfones and in situ oxidized terminal acetylenes are th

71 the reaction between unsubstituted alkyl PT sulfones and linear aliphatic aldehydes.

72 Julia-Kocienski olefination with tetrazolyl sulfones and subsequent macrolactonization.

73 e desired monoarylated alpha-branched benzyl sulfones and sulfonamides were obtained in good yields,

74 um catalyzed Negishi-type alpha-arylation of sulfones and sulfonamides with a broad range of aryl bro

75 into sulfinate intermediates, and onwards to sulfones and sulfonamides, has been realized.

76 ed electrophiles then allows conversion into sulfones and sulfonamides, respectively, in a one-pot, t

77 As monoaza analogues of sulfones and sulfonamides, respectively, they combine go

78 ate intermediates leads to the corresponding sulfones and sulfonamides, two pharmacophores routinely

79 e overoxidation of the product sulfoxides to sulfones and the hydrolysis of epoxides to diols.

80 hotogeneration of aryl radicals from arylazo sulfones and their ensuing reaction with allyl sulfones.

81 nion recognition units containing sulfoxide, sulfone, and sulfoximine groups at C4 unveils an enhance

82 and streamlined syntheses of complex ether, sulfone, and tertiary amine products, some of which woul

83 subsequently converted to gamma-azido vinyl sulfones, and azide-alkyne click chemistry enabled the s

84 including cinnamates, crotonates, coumarins, sulfones, and chalcones were successfully functionalized

85 ons include carboxamides, amines, dithianes, sulfones, and sulfoxides, as well as some ketones, beta-

86 other oxygen-containing species, carbazoles, sulfones, and thiophenes from small crude oil samples (

87 ted oxacycles via intramolecular reaction of sulfone- and nitrile-stabilized carbanions with dialkyl

88 observed that fexinidazole and fexinidazole sulfone are more effective than benznidazole and nifurti

89 Vinyl sulfones are privileged motifs known for their biologica

90 ds, leading to the identification of an aryl sulfone as a replacement for the 3-cyano pyridyl group.

91 activity of parthenolide and identify vinyl sulfones as a new class of potential therapeutics that t

92 Herein, we report arylazopyrazole ureas and sulfones as a novel class of photoswitchable serine hydr

93 Herein, we describe a new class of aryl sulfones as disruptors of the GK-GKRP complex, where the

94 first examples of the use of sulfonamides or sulfones as effective directing groups in metal-catalyze

95 The use of sulfones as electron-withdrawing groups in substrates fo

96 ick chemistry enabled the synthesis of vinyl sulfone-based triazoles as potential nonpeptidic cystein

97 elopment of inhibitors with penems and penam sulfones being amongst the most potent and broad spectru

98 am (formerly AAI101) is a novel penicillanic sulfone beta-lactamase inhibitor active against a wide r

99 d through a dual approach: 1) using CF2 as a sulfone bio-isostere to exploit the unique properties of

100 ent upon the nature of heteroatom (O or S in sulfone) bridging the propargyl arms.

101 s a new synthetic application of fluorinated sulfones, but also provides a new route to fluoroalkyl r

102 mination has been studied for sulfoxides and sulfones, but this represents the first study of interna

103 lpyrrolidine (PhPyr) and phenyl trans-styryl sulfone by visible-light-absorbing colloidal CdS quantum

104 3 mins without formation of the highly toxic sulfone by-product.

105 tion approach for the synthesis of beta-keto sulfones by exploiting differential reactivity pattern o

106 ntitatively oxidized to either sulfoxides or sulfones by treatment with dilute hydrogen peroxide or m

107 n layer anchored on a microporous poly(ether sulfone) by surface grafting.

108 e mono-, di-, and trifluoromethyl heteroaryl sulfones can thus be used as efficient radical fluoroalk

109 Together, these results suggest chlorinated sulfone carbofluoresceins can be promising candidates fo

110 New, chlorinated sulfone carbofluoresceins have low p K(a) values (5.2) a

111 The most active dibenzo[b,d]thiophene sulfone co-polymer has a UV photocatalytic activity that

112 The dibenzo[b,d]thiophene sulfone co-polymer has an apparent quantum yield of 2.3

113 Arylazo sulfones, colored thermally stable derivatives of aryl d

114 r Bay 11-7082 and structurally related vinyl sulfone compounds selectively inhibit NLRP3 inflammasome

115 Methionine sulfone containing peptides CLs J (11) and K (12) may be

116 , a new procedure is described to form vinyl sulfone-containing compounds by selective functionalizat

117 An iron-catalyzed synthesis of sulfur- and sulfone-containing heterocycles is reported.

118 these molecules afforded many potent biaryl sulfone-containing Nampt inhibitors which also exhibited

119 A series of vinyl sulfone-containing peptidomimetics were rationally desig

120 on relevant macrophage cytokine responses, a sulfone-containing phosphorylcholine analogue (11a) was

121 Four sulfone-containing SMAs termed 11a, 11e, 11i and 12b wer

122 Reactions of sulfone-containing substrates are successful only with d

123 he higher and more prolonged exposure of the sulfone derivative.

124 s and LC50s for fipronil and its sulfide and sulfone derivatives were determined for 14 macroinverteb

125 A pair of easily accessible vinyl sulfones derived from styrene epoxide and monotosylated

126 the subsequent oxidation of DMSO to dimethyl sulfone (DMSO(2)) is much slower (0.4 M(-1) s(-1)).

127 to both the organomagnesium nucleophile and sulfone electrophile.

128 noate-enoate, ynoate-enenitrile, and alkynyl sulfone-enenitrile substrates.

129 o-4-iodopyridines to acetylenes activated by sulfone, ester, or ketone groups, followed by intramolec

130 aldehyde aminooxylation, followed by a vinyl sulfone forming Horner-Wadsworth-Emmons olefination.

131 zed one-step synthesis of (hetero)aryl alkyl sulfones from (hetero)arylboronic acids, potassium metab

132 a one-pot sequence for the synthesis of aryl sulfones from simple starting materials.

133 2 fluorotelomer mercaptoalkylamido sulfonate sulfone (FTSAS-SO2), 6:2 fluorotelomerthiohydroxyl ammon

134 The sulfone functional group has a strong capacity to direct

135 ication of drug metabolites that contain the sulfone functional group.

136 iral activity, although the incorporation of sulfone functionality resulted in a decrease in potency.

137 We report here that a sulfone-functionalized tetrahedral carboxylate-based lig

138 2-Bromoallyl sulfones functioned as synthetic equivalents of allenyl

139 otected 1,3-benzothiazol-2-yl (BT) propargyl sulfones gave corresponding BT fluoropropargyl sulfones,

140 The sulfone group also facilitates the formation of a range

141 based on the bioisosteric replacement of the sulfone group with a phosphinate ester and substitution

142 pairs; however, the analogous sulfoxide and sulfone groups are not.

143 Steric bulk around the azido and vinyl sulfone groups plays a significant role in deciding the

144 hain thioether linkages in these polymers to sulfone groups resulted in disruption of the alpha-helic

145 In the absence of the sulfone groups, we discovered that the tetrahedral linke

146 col for the synthesis of gamma-hydroxy vinyl sulfones has been developed using a proline-based aldehy

147 aturated glycosyl and alpha-D-mannopyranosyl sulfones has been developed via ruthenium-promoted direc

148 ion of silyl ketene acetals with N-Boc-amino sulfones has been developed.

149 obenzaldehydes and beta-substituted vinyl PT-sulfones has been realized for the synthesis of 3,4-unsu

150 rier reaction between nitroalkenes and vinyl sulfones has been successfully carried out for the first

151 onjugate additions to alpha,beta-unsaturated sulfones have been investigated, which provided the key

152 Sulfondiimines-the double aza-analogues of sulfones-hold significant potential as leads in discover

153 of F8BT, P3HT, and the dibenzo[b,d]thiophene sulfone homopolymer P10, we demonstrate how differences

154 bsequent ring contraction, the corresponding sulfone in 83% yield.

155 , with O being trapped in a form of dimethyl sulfone in the electrolyte.

156 The reaction gives vinyl sulfones in a regio- and diastereoselective manner, empl

157 rect access to gamma-keto- and gamma-hydroxy sulfones in a simple and reliable way through a sulfa-Mi

158 litates the preparation of a wide variety of sulfones in a straightforward fashion, including six- th

159 conditions to provide the corresponding aryl sulfones in good to excellent yields.

160 o acceptors to access alpha-D-mannopyranosyl sulfones in good yields with high regioselectivity.

161 mild conditions to give 1-(N-acylamino)alkyl sulfones in good yields.

162 eospecific formation of tertiary homoallylic sulfones in high yield.

163 entally for potassium- and lithium-metalated sulfones, in THF and toluene, respectively.

164 ctions with potassium- and lithium-metalated sulfones, in THF and toluene, respectively.

165 he irreversible reactive "warheads" of vinyl sulfone inactivators of cruzain.

166 yme in complex with a covalently bound vinyl sulfone inhibitor (K777).

167 , the reaction between a 6-alkylidiene penam sulfone inhibitor, SA-1-204, in single crystals of OXA-2

168 A specific vinyl sulfone inhibitor, WRR605, synthesized based on the subs

169 ion emerges despite that the penem and penam sulfone inhibitors form different types of intermediates

170 ve been investigated, which provided the key sulfone intermediate in just six steps from commercially

171 ate reagent ensuring robust preparation of a sulfone intermediate; (iii) development of a safe ozonol

172 tes and alpha,beta-unsaturated ketones/vinyl sulfone is shown.

173 When an allenic sulfone is treated under palladium catalysis in the pres

174 When an allenic sulfone is treated with a phosphine nucleophile and a pr

175 neration of enantioenriched sulfonamides and sulfones is an important objective for fields such as or

176 the lipophilicity of ethers, sulfoxides, and sulfones is dramatically increased upon CH(3)/CF(2)H exc

177 roalkylation of isocyanides with fluorinated sulfones is enabled by visible-light photoredox catalysi

178 lfones gave corresponding BT fluoropropargyl sulfones, Julia-Kocienski reagents for the synthesis of

179 urated electrophilic functions such as vinyl-sulfones, -ketones, -esters, and -nitriles.

180 paired with phosphine oxide, sulfoxide, and sulfone Lewis basic groups are explored.

181 An electron-deficient sulfone ligand proved to be key for the successful imple

182 s in the order ethyl acetate << methyl ethyl sulfone < acetonitrile < N,N-dimethylacetamide approxima

183 for the synthesis of alpha-substituted vinyl sulfones makes use of a combination of a triazole gold c

184 polar organics (o-DGT) without a poly(ether sulfone) membrane was developed, calibrated, and field-e

185 fluoromethylsulfonly)imide in the poly(ether sulfone) membrane with average pore size of approximatel

186 tic HLB disk covered by a 0.2 mum poly(ether sulfone) membrane, for monitoring polar organic micropol

187 0, PNU-101603, and PNU-101244 (sulfoxide and sulfone metabolites) at 1000 mg were 839, 3558, and 54 n

188 bases, either K2 CO3 or DBU, and subsequent sulfone-metal exchange and alkylation rapidly assembles

189 The 2-pyridylsulfone is critical for the sulfone-metal exchange because chelation anchors the org

190 The first general sulfone-metal exchange is described.

191 G hydrogel formulation that uses thiol-vinyl sulfone Michael addition for crosslinking.

192 ionality were investigated to control a keto sulfone Michael addition to construct the C7-C12 linkage

193 ating fetal bovine serum onto the poly(ether sulfone) microdialysis membrane.

194 When combined with REs, the sulfone-modified linker affords novel MOFs, RE-hpt-MOF-1

195 lly, replacement of the epoxyketone by vinyl sulfone moieties further improves the selectivity of bet

196 beta2 adrenoceptor agonists incorporating a sulfone moiety on the terminal right-hand-side phenyl ri

197 ree luminophore, which involves the diphenyl sulfone moiety.

198 Except for protonated sulfones, most of the protonated compounds react very sl

199 ng 1,6-diene with allylic sulfide or allylic sulfone motifs enabled a ring-closing/ring-opening casca

200 methionine sulfoximine (MSX) and methionine sulfone (MSO).

201 e show that methionine sulfoxide, methionine sulfone, N-formylkynurenine, kynurenine, oxindolylalanin

202 Our arylazopyrazole ureas and sulfones offer synthetically accessible scaffolds that c

203 A methoxycarbonyl-substituted vinyl sulfone on reactions with organic azides resulted in the

204 The benzyl styryl sulfone, ON 01910.Na, is a novel anticancer agent that i

205 r fused 6,5-heterocyclic moieties and biaryl sulfone or sulfonamide motifs.

206 s that are different from those observed for sulfones or aromatic carboxylic acids.

207 By using alkynyl sulfones or sulfonates as substrates, the oxidative gold

208 s with m-CPBA to yield the corresponding bis-sulfones (or tetraoxides).

209 rotonated analytes with a carboxylic acid, a sulfone, or a sulfonamide functionality formed diagnosti

210 ery of irreversible inhibitors with p-fluoro-sulfone- or p-fluoro-nitro-substituted N-1 benzyl groups

211 Fipronil and fipronil sulfone (oxidation derivative) each accounted for about

212 f key hydrogen bond anchors between compound sulfone oxygen atoms and Ral backbone nitrogen atoms.

213 asopharyngeal specimens through a poly(ether sulfone) paper matrix, H1N1-specific in situ isothermal

214 unctional groups (aldehyde, ketone, nitrile, sulfone, pentafluorosulfur, and N-aryltrifluoroacetamide

215 In this work, a highly permeable poly(ether sulfone) (PES) based hollow fiber membrane was developed

216 ol (HPG), and then grafting it on poly(ether sulfone) (PES) hollow fiber membrane supports.

217 near triatomic anion, SeCN(-), in poly(ether sulfone) (PES) membranes and room-temperature ionic liqu

218 surface of commercially available poly(ether sulfone) (PES) membranes using the polyelectrolyte multi

219 afted on the substrate surface of poly(ether sulfone) (PES) membranes via covalent bonding.

220 onic acid (AMPS) onto microporous poly(ether sulfone) (PES) substrates and successfully demonstrated

221 enyl)benzene monomers on top of a poly(ether sulfone) (PES) ultrafiltration membrane support.

222 Poly(ether sulfone) (PES)/polyvinylpyrrolidone (PVP) membranes are

223 with model electrolyte solvents (carbonate, sulfone, phosphate, and ether) on the stability of high-

224 These sulfones possess red-shifted absorption and emission spe

225 lfur dioxide from the respective 16-membered sulfone precursors.

226 Another set of exocyclic vinyl sulfones prepared from 3-O-methylated- and 3-O-benzylate

227 nation reaction that releases a methyl vinyl sulfone product and the parent IPA/NO anion which subseq

228 CEESO) without formation of the highly toxic sulfone product.

229 Overall, heteroaromatic sulfones provide modular tunability, shifted chromatogra

230 sulfinate salts yields the much more stable sulfone radicals, which smoothly add to double bonds.

231 Heteroaromatic sulfones react with cysteine via nucleophilic aromatic s

232 This method highlights sulfone reactivity and provides an easy approach for the

233 hat the C2 hydroperoxide of dibenzothiophene sulfone reacts with flavin to form a flavin-N5-oxide.

234 An azanorbornadiene bromovinyl sulfone reagent for cysteine-selective bioconjugation ha

235 rt the one-step synthesis of poly(aryl ether sulfone)s (PSUs) from the depolymerization of PCs and in

236 tures of SHV-1 bound with penem 1, and penam sulfones SA1-204 and SA3-53.

237 nd biological profile of a novel spirocyclic sulfone series of gamma-secretase inhibitors (GSIs) rela

238 ridone derivatives containing sulfoxides and sulfones showed cellular activity against M. tuberculosi

239 lfur from sulfide (S), to sulfoxide (SO), to sulfone (SO2).

240 idge from sulfide (S), to sulfoxide (SO), to sulfone (SO2).

241 henylsulfonyl)vinyl AA-esters undergo smooth sulfone-stannane interchange to stereoselectively give t

242 Sulfone-substituted gamma- and delta-lactams have been p

243 Vinylic, allylic and homoallylic sulfone substitutions were investigated, and high enanti

244 nism among different bispropargyl substrates-sulfone, sulfide, ether, amine, and methane-toward Garra

245 Being mono-aza analogues of sulfoxides and sulfones, sulfimides and sulfoximines, respectively, are

246 This system validates sulfone-sulfone bonding for dynamic self-assembly, prese

247 assembly is directed by dynamic noncovalent sulfone-sulfone bonds that are susceptible to solvent po

248 onyl-containing functional groups, including sulfones, sulfonyl chlorides, and sulfonamides.

249 h as alpha,beta-unsaturated ketones, esters, sulfones, sulfoxides, and phosphonates to yield the corr

250 The reported sulfone synthesis can be performed either as a direct on

251 A variety of electron deficient allyl sulfone systems could be used as delta-carbon radical ac

252 tribenzoate, DCDPS = 4,4'-dicarboxydiphenyl sulfone, TCPP = tetrakis(4-carboxyphenyl)porphyrin).

253 Rigosertib is a styryl benzyl sulfone that inhibits growth of tumor cells and acts as

254 ions of racemic alpha-bromosulfonamides and -sulfones that furnish the desired cross-coupling product

255 orates with a variety of substituted alkenyl sulfones through an alpha-aminomethyl radical addition-e

256 involving the conversion of dibenzothiophene sulfone to 2-(2-hydroxyphenyl)-benzenesulfinic acid, is

257 ctive pyrone Diels-Alder reaction of a vinyl sulfone to construct the cyclophane architecture of the

258 ximal to the electrophilic, tetrasubstituted sulfone to override complex-induced deprotonation.

259 The ability of 1,6-diene-fused allylic sulfone to undergo efficient SO(2) extrusion generated a

260 nating reagent for the one-pot conversion of sulfones to alkenes by way of the Ramberg-Backlund rearr

261 nctioned as synthetic equivalents of allenyl sulfones under these conditions.

262 Our results suggest that the sulfones undergo a relatively fast isomerization followe

263 benzo[b,d]thiophene or dibenzo[b,d]thiophene sulfone units greatly enhances the H2 evolution rate.

264 othiadiazepine 2,2-dioxide, the formation of sulfone via o-quinodimethane is the preferred pathway fr

265 tain alkyl alkynyl sulfones and cyclic vinyl sulfones via 1,2-rearrangement or 1,5-CH insertion, resp

266 ides a new avenue for the synthesis of vinyl sulfones via a decarboxylative radical coupling strategy

267 n of aryl ester pronucleophiles to vinyl bis-sulfones via C(1)-ammonium enolate intermediates has bee

268 or the construction of alpha-alkyl-beta-keto sulfones via C(sp(3))-H bond functionalization followed

269 nsition-metal-free one-pot synthesis of aryl sulfones via the reactive quinone imine ketal intermedia

270 dratase (DH) domains by means of a 3-alkynyl sulfone warhead.

271 tert-butoxycarbonyl)methylidenecephalosporin sulfone was examined kinetically, spectroscopically, and

272 ence of other functionalities in addition to sulfone was found not to influence the diagnostic reacti

273 The resulting sulfone was reacted with aldehydes to access beta-substi

274 Their oxidation to sulfones was also demonstrated to have no effect on thei

275 lfinates for the synthesis of arylacetylenic sulfones was developed.

276 tion of terminal alkynes to branched allylic sulfones was developed.

277 ve Ir-catalyzed hydrogenation of unsaturated sulfones was developed.

278 sulfoxide, dimethyl sulfone and ethyl methyl sulfone were responsible for 'sulfurous' aroma.

279 Instead, 3,5-bis(trifluoromethyl)phenyl sulfones were employed, thereby simultaneously retaining

280 as observed, while only small amounts of the sulfones were formed, if any.

281 In addition, alkyl phenyl sulfones were found to be effective electrophiles in the

282 Thus, highly functionalized vinyl sulfones were obtained in moderate to good yields.

283 Chiral cyclic and acyclic sulfones were produced in excellent enantioselectivities

284 y photo-oxygenation products (sulfoxides and sulfones) were found.

285 replaced with oxygen, sulfur, sulfoxide, and sulfone, were prepared by a short sequence from the ethy

286 ompounds, comprising endoperoxides and vinyl sulfones, were capable of high activity profiles compara

287 As sulfoximines are analogues of sulfones where one of the two S[double bond, length as m

288 d with acrylates, styrenes, and vinyl phenyl sulfones, whereas the saturated alkylation products were

289 ed to the discovery of a one-carbon tethered sulfone which gave rise to substantial improvements in b

290 cycles were converted into the corresponding sulfones which were used as precursors of novel benzo-2,

291 ammatory drugs sulindac sulfide and sulindac sulfone, which attenuate beta-catenin transcription acti

292 y drug sulindac and its metabolite, sulindac sulfone, which were readily distinguished.

293 onformity with a diradical mechamism for the sulfone, while for the ether, the anionic [4 + 2] appear

294 ic fragment ions of m/z 75, 105, and 123 for sulfones, while an additional methanol elimination was o

295 hly reactive S(N)Ar reaction of 4-quinolinyl sulfones with a range of structurally diversified 1 degr

296 ceptorless dehydrogenative coupling of alkyl sulfones with alcohols.

297 fonyl hydrazides to produce branched allylic sulfones with good to excellent yields and selectivities

298 a variety of (enantiopure) trans-cyclopropyl sulfones with high diastereoselectivity.

299 een developed that allows the union of vinyl sulfones with photoredox-generated alpha-amino radicals

300 Suzuki-Miyaura coupling of borylated allylic sulfones with various electrophiles in both inter- and t