ライフサイエンスコーパス: sulfonyl

1 1,2-Bis(sulfonyl)-1-alkylhydrazines (BSHs) were conceived as mor

2 diverse rhodium vinylcarbenes from stable 1-sulfonyl-1,2,3-triazole precursors has been developed.

3 lecular denitrogenative transannulation of N-sulfonyl-1,2,3-triazole-tethered cyclohexadienones has b

4 This methodology utilizes 4-aryl-1-sulfonyl-1,2,3-triazoles as carbenoid precursors and the

5 will describe the recent advances in using N-sulfonyl-1,2,3-triazoles as precursors for the formation

6 n of fused dihydroazepine derivatives from 1-sulfonyl-1,2,3-triazoles bearing a tethered diene is rep

7 re synthesized from 5-alkoxyisoxazoles and 1-sulfonyl-1,2,3-triazoles by tuning the Rh(II) catalyst a

8 a rhodium-catalyzed reaction of 4-alkenyl-1-sulfonyl-1,2,3-triazoles featuring an unusual 4pi electr

9 d reaction of 2,2-diaryl-2 H-azirines with 1-sulfonyl-1,2,3-triazoles has been developed.

10 nsition-metal-catalyzed denitrogenation of 1-sulfonyl-1,2,3-triazoles has emerged as a powerful strat

11 produced from readily available and stable 1-sulfonyl-1,2,3-triazoles in the presence of a rhodium ca

12 enerated from readily available and stable 1-sulfonyl-1,2,3-triazoles in the presence of chiral Rh(II

13 or the ring expansion and rearrangement of 1-sulfonyl-1,2,3-triazoles under rhodium(II)-catalyzed con

14 lyzed and base-mediated transannulation of N-sulfonyl-1,2,3-triazoles with a Michael acceptor-tethere

15 Rhodium-catalyzed transannulation of N-sulfonyl-1,2,3-triazoles with vinyl ether has been accom

16 inyl carbenes, conveniently generated from 1-sulfonyl-1,2,3-triazoles, undergo a facile, mild, and co

17 s using 3-diazoindolin-2-imines instead of 1-sulfonyl-1,2,3-triazoles.

18 identified a potent interaction between the sulfonyl-1,2,4-thiadiazole (compound 187) and FhTIM, whi

19 ienes, which rapidly cyclize to 2,2-diaryl-1-sulfonyl-1,2-dihydropyrazines.

20 ective construction of the highly strained 2-sulfonyl-1,3-diazabicyclo[3.1.0]hexane structures in hig

21 A method to prepare 1-substituted 3-sulfonyl-1H-pyrroles efficiently that relies on the gold

22 cation of 2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phen yl)-1,1,1

23 talyzed intramolecular aminooxygenation of N-sulfonyl-2-allylanilines and 4-pentenylsulfonamides to a

24 intramolecular annulation of the resulting 3-sulfonyl-2-benzylchroman-4-ols.

25 ing (i) NaBH(4)/LiCl-mediated reduction of 3-sulfonyl-2-benzylchromen-4-ones and (ii) sequential BF(3

26 receptor antagonist (2R)-1-[(3-hydroxyphenyl)sulfonyl]-2 -(2-(4-methyl-1-piperidinyl)ethyl)pyrrolidin

27 lar inhibitor of ALDH3A1, 1-[(4-fluorophenyl)sulfonyl]-2-methyl-1H-benzimidazole (CB7, IC50 of 0.2 mu

28 ility of a DH-specific probe that contains a sulfonyl 3-alkyne reactive warhead engineered to avoid h

29 antibiotic susceptibility, suggest that this sulfonyl 3-alkyne scaffold selectively targets a common

30 protein NMR spectroscopy to demonstrate that sulfonyl 3-alkynyl pantetheinamide is fully sequestered

31 ucts possessing a synthetically useful 1-bis-sulfonyl-3-nitroalkene moiety in good to excellent yield

32 at C-9 methylene bridge is developed from N-sulfonyl-4-biaryl-1,2,3-triazole derivatives via Rh-cata

33 F-(N-[[29-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,19-bi phenyl]-2-yl]methyl]-N,

34 anism of CCG-4986 [methyl-N-[(4-chlorophenyl)sulfonyl]-4-nitro-benzenesulfinimidoate], a previously r

35 ulted in identification of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1

36 to the regiocontrolled domino formation of N-sulfonyl-6,7-dihydro-5H-dibenzo[c,e]azepines over the bi

37 le, a high-yield method for the synthesis of sulfonyl 9-fluorenylidenes is described, which consists

38 Finally, sulfonyl acetylenes are efficient for alkyne transfer on

39 more extensive structural exploration of the sulfonyl acrylonitrile chemotype may result in useful in

40 Here, we describe a distinct set of sulfonyl acrylonitrile inhibitors that also emerged from

41 previously that (2E)-3-[(4-tert-butylphenyl)sulfonyl]acrylonitrile (1) induced cancer cell apoptosis

42 e-pot transformation of the products to beta-sulfonyl-alpha,beta-unsaturated ketoximes has also been

43 ddition/decarboxylation cascade synthesis of sulfonyl amidines from sulfonyl azides and substituted a

44 ing this simple protocol, a diverse range of sulfonyl amidines was obtained in moderate to excellent

45 decarboxylation, which liberates the desired sulfonyl amidines, generating N2 and CO2 as the only rea

46 l-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinyl methyl)-acetamide (EMPA),

47 (N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl) -1-piperazinyl]carbo

48 N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1 -piperazinyl]carbo

49 This study describes novel N-sulfonyl-aminobiaryl (biaryl-benzenesulfonamides) as pot

50 A series of N-sulfonyl-aminobiaryl derivatives have been examined as n

51 alyzed cycloisomerization of N-substituted N-sulfonyl-aminobut-3-yn-2-ols is described.

52 palladium(II) acetate to afford the E-isomer sulfonyl analogues of cinnamoyl fluoride in 43-97 % yiel

53 s more ketenophilic bis-silyl ynamines and N-sulfonyl and N-phosphoryl ynamides serve as the reaction

54 ives an easy entry to optically active alpha-sulfonyl- and alpha-phosphoryl oxyketones in respectable

55 We now report the synthesis of sulfonyl- and cyano-substituted oxacycles via intramolec

56 wis acid-mediated [3 + 2] cycloaddition of N-sulfonyl- and N-sulfamoylaziridines with alkenes provide

57 The preparation and chemistry of novel sulfonyl- and phosphoryl-derived lambda(3)-iodanes are r

58 r of acetylenes, leading to hitherto unknown sulfonyl- and phosphoryl-substituted phosphinolines, pho

59 Allylation of the intermediate alpha-sulfonyl anion is more rapid than racemization, leading

60 The corresponding alpha-sulfonyl anion reacts smoothly with diverse alkyl halide

61 ydrazone has been identified as an excellent sulfonyl anion surrogate in the DBU-catalyzed conjugate

62 nyl sulfone and in situ traping of the allyl sulfonyl anion with a CD ring allyl chloride.

63 synthesis of a novel ionic liquid-supported sulfonyl azide and its applications as diazotransfer rea

64 Imidazole-1-sulfonyl azide and salts thereof are valuable reagents f

65 ibe the development of lissamine rhodamine B sulfonyl azide as a sensitive click reagent for the dete

66 e recently reported bench-stable imidazole-1-sulfonyl azide as diazotransfer reagent, this new method

67 Imidazole-1-sulfonyl azide hydrochloride, an inexpensive and effecti

68 Imidazole-1-sulfonyl azide hydrogen sulfate is presented as an effic

69 Imidazole-1-sulfonyl azide hydrogen sulfate provides a considerable

70 group of promising scavengers, based on the sulfonyl azide template.

71 gent, several different salts of imidazole-1-sulfonyl azide were prepared, and their sensitivity to h

72 + 2 + 2]/[NC + CC + NC] cycloaddition, using sulfonyl azide, alkyne, and quinoline, to prepare pyrimi

73 st direct observation of the S(1) state of a sulfonyl azide, and this vibrational feature allows a me

74 t formation of substituted sulfonamides from sulfonyl azides and amines via nucleophilic substitution

75 lfonamides via the carbonylative coupling of sulfonyl azides and electron-rich heterocycles.

76 cascade synthesis of sulfonyl amidines from sulfonyl azides and substituted amides at low CO pressur

77 sulfonyl carbamates and sulfonyl ureas from sulfonyl azides employing a palladium-catalyzed carbonyl

78 as an efficient reagent for the synthesis of sulfonyl azides from primary sulfonamides.

79 xo mode starting from 2-ethynylbiaryls and N-sulfonyl azides in one pot.

80 en readily accessible propargyl acetates and sulfonyl azides in the presence of CuI catalyst yields t

81 2,3-triazoles from 2-cyanothioacetamides and sulfonyl azides is described.

82 N'-bis-(2-cyanothiocarbonyl)pyrazine 1h with sulfonyl azides to afford bicyclic 1,2,3-thiadiazoles 8

83 contrast to aromatic azides and similarly to sulfonyl azides, 6-azidopyrimidine-2,4-diones 2o-q react

84 e coupling of salicylaldehydes, propiolates, sulfonyl azides, and secondary amines.

85 etween indoles or pyrroles, ynol ethers, and sulfonyl azides, creating four different bonds regiosele

86 tive generation of sulfonyl isocyanates from sulfonyl azides, followed by a [2 + 2] cycloaddition wit

87 Using a two-chamber system, sulfonyl azides, PdCl2, and CO gas, released ex situ fro

88 s, that is, avoiding the isolation of unsafe sulfonyl azides.

89 hemistry from readily accessible alkynes and sulfonyl azides.

90 tramolecular C-H bond amination reactions of sulfonyl azides.

91 pairing of heretofore-unknown (o-fluoroaryl)sulfonyl aziridine building blocks with an array of amin

92 -catalyzed cross-coupling reaction between N-sulfonyl aziridines and organozinc reagents is reported.

93 l]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl] benzamide (navitoclax), a Bcl-2/Bcl-xL/Bcl-w i

94 oromethyl)phosphonate, [(bromodifluoromethyl)sulfonyl]benzene, and ethyl 2-bromo-2-fluoroacetate were

95 the AMPAR antagonist 2,3-dihydroxy-6-nitro-7-sulfonyl-benzo[f]quinoxaline (NBQX) protected against th

96 le, processes which introduce the most basic sulfonyl building block, sulfur dioxide, using catalytic

97 fo (NSA)Neu5Ac) combined the lead 2-naphthyl sulfonyl C-9 substituent with the preferred sulfated sca

98 An efficient synthesis of sulfonyl carbamates and sulfonyl ureas from sulfonyl azi

99 d as nucleophiles to afford a broad range of sulfonyl carbamates and sulfonyl ureas.

100 atory Oxaprozin was prepared using the alpha-sulfonyl carbanion strategy along with optimized desulfo

101 ition or 1,4-/1,2-reduction of the resulting sulfonyl chalcones in THF or MeOH/THF at 25 degrees C; a

102 C2-, and (13)C4-5-diethylamino-naphthalene-1-sulfonyl chloride (DensCl), in combination with liquid c

103 ns can be achieved when the electronics of a sulfonyl chloride activator and the reactivity of a glyc

104 trazolopyridines by treatment with 4-toluene sulfonyl chloride and sodium azide in toluene at elevate

105 s/pyrazines/pyridazine with 2-chloro benzene sulfonyl chloride followed by a Cu(I)-catalyzed Ullmann-

106 rivatization reagent 1,2-dimethylimidazole-5-sulfonyl chloride is its analyte-specific fragmentation

107 phase, PBS buffer, and rat serum of 12 aryl sulfonyl chloride precursors with various substituents (

108 reaction protocol avoids the need to employ sulfonyl chloride substrates, thus removing the limitati

109 yrazines/pyridazines on the 2-chloro benzene sulfonyl chloride, followed by Cu(I)-catalyzed ipso chlo

110 onstrate that activating a hemiacetal with a sulfonyl chloride, followed by treating the resultant gl

111 es/pyrazines/pyridazine and 2-chloro benzene sulfonyl chloride.

112 Aryl sulfonyl chlorides (e.g. Ts-Cl) are beloved of organic c

113 d can be extended to the one-pot reaction of sulfonyl chlorides and 6-chloropyrimidines 2'o with sodi

114 Sulfonyl chlorides are inexpensive reactants extensively

115 herein are generated from the corresponding sulfonyl chlorides by treatment with zinc dust.

116 However, sulfamoyl and sulfonyl chlorides can be easily activated by Cl-atom ab

117 [(18)F]Radiolabeling of sulfonyl chlorides in the presence of competing nucleoph

118 catalyzed deoxygenative O-atom transfer from sulfonyl chlorides is reported.

119 adicals were generated from their respective sulfonyl chlorides under mild, metal-free conditions lea

120 ining functional groups, including sulfones, sulfonyl chlorides, and sulfonamides.

121 ore challenging for sulfamoyl chlorides than sulfonyl chlorides.

122 onylation of electron-deficient alkenes with sulfonyl chlorides.

123 ons via the formation of the intermediate of sulfonyl chroman-4-one.

124 Several chiral sulfonyl compounds were prepared using the iridium catal

125 ucts are converted in situ into a variety of sulfonyl-containing functional groups, including sulfone

126 B(C6F5)3 activates N-sulfonyl cyanamides, thus leading to a formal cleavage o

127 ester building blocks by diazotization of S-sulfonyl-cysteines.

128 ection of the 4-(dimethylamino)azobenzene-4'-sulfonyl derivative of l-methionine (dabsyl Met), the pr

129 apoptosis induction, while some sulfinyl and sulfonyl derivatives (5b, 5c, and 6a-c) were highly effi

130 Sulfonyl-derived functional groups populate a broad rang

131 s work, a concise route for the synthesis of sulfonyl dibenzo-oxabicyclo[3.3.1]nonanes by a two-step

132 nd 2-allylbenzaldehydes provides tetracyclic sulfonyl dihydrobenzo[c]xanthen-7-one core with good to

133 first time, providing a workable access to N-sulfonyl dihydrophenanthridines in good to excellent yie

134 ination-directed [3 + 3] annulation involves sulfonyl elimination via O-S or C-S bond cleavage, affor

135 oselective synthesis of a wide range of beta-sulfonyl enamines without electron-withdrawing groups on

136 ument the failure of the previously reported sulfonyl ester pharmacophore to confer Tdp1 inhibition i

137 In contrast, a sulfonyl, ester-substituted alkyne is reactive enough th

138 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), was characterized us

139 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide 3 (GSK3787) was identified as a

140 The intermediates contain a 3-sulfonyl flavanone motif.

141 ing method for the gram-scale synthesis of 3-sulfonyl flavanones is described by a one-pot straightfo

142 d binding orientation and sheds light on the sulfonyl fluoride activation leading to the sulfonamide

143 We now report on later generation sulfonyl fluoride analogs that exhibit potent and select

144 firmed a chemoselective reaction between the sulfonyl fluoride and a conserved lysine in the ATP bind

145 formed by a non-enzymatic reaction between a sulfonyl fluoride and an amino group.

146 s substituted at the 2 position with an aryl sulfonyl fluoride and at the 5 position with a substitut

147 h the members contain an amino acid inspired sulfonyl fluoride as the electrophilic trap.

148 port that covalent bond formation by an aryl sulfonyl fluoride electrophile at a tyrosine residue (Ty

149 oupling that is compatible with the aromatic sulfonyl fluoride functional group.

150 y, in which either the alkenyl moiety or the sulfonyl fluoride group can be the exclusive site of nuc

151 gh SuFEx click derivatization of the pendant sulfonyl fluoride group in 96 well-plates-demonstrating

152 In total, 24 peptido sulfonyl fluoride inhibitors have been designed and synt

153 A number of the peptido sulfonyl fluoride inhibitors were found to be highly sel

154 he membranes was achieved by reacting Nafion sulfonyl fluoride poly(perfluorosulfonyl fluoride) membr

155 highlighting the utility of lysine-targeted sulfonyl fluoride probes in demanding chemoproteomic app

156 Here, we report the design of sulfonyl fluoride probes that covalently label a broad s

157 f apoptosis protein (XIAP) using a benzamide-sulfonyl fluoride warhead.

158 se inhibitor AEBSF (4-[2-aminoethyl] benzene sulfonyl fluoride) up-regulated full-length Dicer, both

159 We showcase 2-Substituted-Alkynyl-1-Sulfonyl Fluorides (SASFs) as a new class of connective

160 leaving group (LG) in covalent reactions of sulfonyl fluorides and arylfluorosulfates.

161 nd bis(trifluoromethyl)sulfur oxyimines from sulfonyl fluorides and iminosulfur oxydifluorides, respe

162 Sulfonyl fluorides are known to inhibit esterases.

163 Sulfonyl fluorides are valuable synthetic motifs for a v

164 fers facile access to a wide range of biaryl sulfonyl fluorides as bioorthogonal "click" reagents.

165 versatility and potential utility of [(18)F]sulfonyl fluorides as synthons for indirect radiolabelin

166 Additionally, sulfonyl fluorides can be converted to aryl sulfonamides

167 A few of the aryl sulfonyl fluorides efficiently form conjugates with TTR

168 lectfluor has been developed generating aryl sulfonyl fluorides in good to excellent yields.

169 the thyroxine binding site, most of the aryl sulfonyl fluorides react rapidly and chemoselectively wi

170 -catalyzed conversion of aryl iodide to aryl sulfonyl fluorides using DABSO and Selectfluor has been

171 y benign electrochemical approach to prepare sulfonyl fluorides using thiols or disulfides, as widely

172 lyl ethers and aryl fluorosulfates (or alkyl sulfonyl fluorides).

173 is lower than that of the corresponding aryl sulfonyl fluorides, which are better characterized with

174 ed by cyclization of the corresponding amino sulfonyl fluorides.

175 trapping with an F electrophile delivers the sulfonyl fluorides.

176 ion of electronically and sterically diverse sulfonyl fluorides.

177 itroallylic acetates yields tetrasubstituted sulfonyl furans through a cascade S(N)2'-intramolecular

178 es are obtained with an electron-withdrawing sulfonyl group (left).

179 nal and internal alkynes bearing a 2-pyridyl sulfonyl group (SO2Py) at the propargylic position affor

180 onstrated that a small compound containing a sulfonyl group acts as inhibitor of catBoNT/A through co

181 g situating adjacent to the active site, its sulfonyl group adopting a sharp kink, and its N-CF(3)-ph

182 The size of the substrate's N-sulfonyl group also influences the enantioselectivity of

183 ,1-deactivated olefins substituted with a BT-sulfonyl group and a carbonyl or nitrile, respectively,

184 izing donor-acceptor interaction between its sulfonyl group and Ni(II).

185 ination mode, in which an oxygen atom of the sulfonyl group coordinates to Pd.

186 Such a sulfonyl group dance (functional group swap) results fro

187 In addition, the presence of the BT-sulfonyl group in prepared structures allows for further

188 The sulfonyl group in the tail of compounds 1 and 2 is invol

189 The sulfonyl group is demonstrated to be an effective direct

190 Substituted anilines containing a sulfonyl group may be oxidized in situ in the presence o

191 s, whereas electron-rich substrates provided sulfonyl group migration products.

192 Use of an electron-donating sulfonyl group results in an unanticipated aza-Michael/a

193 rogen substituent at 2-position directed the sulfonyl group to the N-3 position, while alkylsulfanyl

194 nodihydrofurans, respectively, bearing a key sulfonyl group, in excellent yields with a broad substra

195 a longer perfluoroalkyl chain and a bulkier sulfonyl group, when compared to PFOAAmS.

196 the presence or absence of the N-(2-pyridyl)sulfonyl group.

197 eaction taking advantage of the N-(2-pyridyl)sulfonyl group.

198 of the tether and the presence or absence of sulfonyl groups.

199 ular amination of an N-guanidyl pyrrole by a sulfonyl guanidine.

200 nvolves the transformation of a variety of N-sulfonyl heterocycles and phenyl benzenesulfonates to th

201 toskeletal networks with 5-iodonaphthalene-1-sulfonyl homopiperazine and cytochalasin D abolished the

202 4-bromophenyl)-2-oxo-2,3-dihydro-1H-indole-5-sulfonyl hydrazide 40, which demonstrated 59% oral bioav

203 Using various sulfonyl hydrazides as the sulfonyl precursor, a series

204 catalyst system, terminal alkynes react with sulfonyl hydrazides to produce branched allylic sulfones

205 aldehydes, respectively and (2) utilizing a sulfonyl hydrazine polymer treatment.

206 Ionic liquid-supported sulfonyl hydrazine was synthesized and reacted with a nu

207 Subsequent hydrolysis of the beta-hydroxy N-sulfonyl hydrazone products produces the corresponding b

208 port here an asymmetric boronate addition to sulfonyl hydrazones catalyzed by chiral biphenols to acc

209 tuted diazo reagents, generated in situ from sulfonyl hydrazones in the presence of base, can serve a

210 ive production of alpha-alkyl-beta-hydroxy N-sulfonyl hydrazones with alpha-quaternary centres.

211 dition of Grignard reagents to alpha-epoxy N-sulfonyl hydrazones-directed by the alkoxide of the 1-az

212 nd N-alkyl arylamines using NH2/NH(alkyl)-O-(sulfonyl)hydroxylamines as aminating agents; the relativ

213 uthyl-methylpyrolydinium bis (trifluromethyl sulfonyl) imide [C(4)mpyr][NTf(2)].

214 RILs, protonated betaine bis(trifluoromethyl sulfonyl)imide ([Hbet][Tf2N]) and choline bis(trifluorom

215 ionomers that contain either one or two bis(sulfonyl)imide groups on the side-chain in addition to a

216 hyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imide in an operating EDLC with electrodes comp

217 tyl-3-methylimidazolium bis(trifluoromethane-sulfonyl)imide, improves stability of the antibody.

218 enzimidazolium)dodecane bis[(trifluoromethyl)sulfonyl]imide bromotrichloroferrate(III) ([(C16BnIM)2C1

219 ordinate to the Cl, N, and O of alpha-chloro sulfonyl imine substrates is supported by computational

220 delta-acetoxy allenoates react with cyclic N-sulfonyl imines (sulfamidate imines/sulfonyl imines) to

221 nonstabilized azomethine ylides and cyclic N-sulfonyl imines has been developed providing a workable

222 cyclic N-sulfonyl imines (sulfamidate imines/sulfonyl imines) to afford functionalized 2-pyridinyl ac

223 applied to the synthesis of N-sulfinyl and N-sulfonyl imines, but its general validity has been prove

224 carbonyl group in the parent compound with a sulfonyl in the PDK inhibitors.

225 ld synthetic routes for the preparation of 2-sulfonyl indenes and indanes, including: (i) Amberlyst-1

226 (2(2,4-difluoro phenoxymethyl)-pyrrolidine-1-sulfonyl)isatin ((18)F-ICMT-11), has been developed for

227 -7-halogen-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins were developed as a new group of nonrad

228 eaction proceeds via in situ generation of a sulfonyl isocyanate followed by regioselective acylation

229 ial Pd-catalyzed carbonylative generation of sulfonyl isocyanates from sulfonyl azides, followed by a

230 itu from Mo(CO)6, were assembled to generate sulfonyl isocyanates in situ, and alcohols and aryl amin

231 ound of this series, 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6-diol, designated PS10, inhibits

232 s-alpha,beta-unsaturated N-tosylamides via N-sulfonyl ketenimine formation followed by a probable 1,3

233 This domino process involves a range of N-sulfonyl ketimines as C,N-binucleophiles, enolizable ket

234 Increasing the pK(a) of the acyl-sulfonyl linker yielded incremental enhancements, while

235 this transformation is ester << amide < H < sulfonyl < benzoyl << nitro.

236 ical properties of {(7R)-7-[[(4-fluorophenyl)sulfonyl](methyl)amino]-6,7,8,9-tetrahydropyrido[1,2-a]

237 An unexpected 1,3-sulfonyl migration was observed and further analyzed.

238 ate undergoes dehydration and deaurative 1,3-sulfonyl migration, a process that remains rare in gold

239 ization, thiophenol elimination, and N- to O-sulfonyl migration, giving 2-sulfonate-substituted pyrid

240 f prodrugs, increasing the pK(a) of the acyl-sulfonyl moiety, modulation of the lipophilicity, and st

241 Both the electronic and steric nature of the sulfonyl moiety, which serves as a base-labile protectin

242 The best ligand, 9-N-(2-naphthyl-sulfonyl)-Neu5Acalpha2-3-[6-O-sulfo]-Galbeta1-4GlcNAc (6

243 Thermally persistent triplet sulfonyl nitrene, FSO(2)N, was produced in the gas phase

244 onyl, imidoyl, boryl, silyl, phosphonyl, and sulfonyl nitrenes are included.

245 ted domino double cyclocondensation of alpha-sulfonyl o-hydroxyacetophenones and 2-allylbenzaldehydes

246 ecular desulfonylative condensation of alpha-sulfonyl o-hydroxyacetophenones with 2-formyl azaarenes

247 The o-nitration process provides a series of sulfonyl o-nitrostyrenes.

248 -catalyzed aminooxygenation/cyclization of N-sulfonyl-O-butenyl hydroxylamines in the presence of (2,

249 n-withdrawing nonparticipating group, benzyl sulfonyl, on 2-O, an increase in beta-product was observ

250 three-component reaction of alkyne, azides (sulfonyl or phosphoryl azides), and N,N-dialkyloxyformam

251 ulfonyl residue could be replaced by various sulfonyl- or urethane-like protecting groups.

252 ones 1 and o-formyl allylbenzenes 2 provides sulfonyl oxabenzo[3.3.1]bicyclic core 4 in a cosolvent o

253 ntioselective oxyamination of alkenes with N-sulfonyl oxaziridines is catalyzed by a novel iron(II) b

254 We have discovered that N-sulfonyl oxaziridines react with a broad range of olefin

255 3) inhibitor 2-hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid (NSC74859).

256 regio- and stereoselective fluorination; the sulfonyl oxygen atoms are proposed to direct the fluorin

257 A close interaction between nickel and a sulfonyl oxygen of tosylate during oxidative addition is

258 and 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl (Pbf), three acid-labile protecting groups most

259 ated a 4-piperazinylquinoline scaffold and a sulfonyl phamarcophore.

260 -(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970) was performed on pig brain s

261 8-(4-((4-(4-Bromophenyl)piperazin-1-yl)sulfonyl)phenyl)-1-propylxanthine (34, PSB-1901) was the

262 12, (E)-3-(3-((1H-pyrrolo[2,3-b]pyridin-1-yl)sulfonyl)phenyl)-N-hydroxyacrylamide, which has a 7-azai

263 yl)amino)-6-(4-((4-methyl-1,4-diazepan-1- yl)sulfonyl)phenyl)quinoline-3-carbonitrile (NEU-924, 83) f

264 603 [(8-[4-[4-((4-chlorophenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine].

265 lfanyl)-2-butanyl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl] benzamide (navitoclax), a Bcl-

266 nd 2,4-dichloro-N-{4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}benzamide (ChemBridge ID5217941)] sharin

267 by accumulation of N-(lissamine rhodamine B sulfonyl)phosphatidylethanolamine (N-Rh-PE), a lipid mar

268 nd p-toluenesulfonyl azide gives access to N-sulfonyl phosphoramidines in good to excellent yields.

269 to the recent discovery of an LpxH-targeting sulfonyl piperazine compound (referred to as AZ1) by Ast

270 Remarkably, none of the sulfonyl piperazine compounds occupies the active site o

271 Using various sulfonyl hydrazides as the sulfonyl precursor, a series of sulfonylated indazole de

272 tion of 1,3-oxazoles containing a variety of sulfonyl-protected alkylamino groups in the fifth positi

273 lysts for the reductive deprotection of aryl sulfonyl-protected phenols.

274 modeled ligands, 3-nitro-5-((trifluoromethyl)sulfonyl)pyridine-2(1H)-one (L8) is found to be highly v

275 ive S(N)Ar substitution of the corresponding sulfonyl pyridines.

276 ion of the terminal alkyne and addition of a sulfonyl radical to the resultant vinyl azide.

277 catalyst-free approach for the generation of sulfonyl radicals from aryldiazonium tetrafluoroborates

278 erate alkyl, alpha-acyl, trifluoromethyl and sulfonyl radicals.

279 id H2O adsorption takes place at hydrophilic sulfonyl/salt groups on domain surfaces at low RH, while

280 While attempts to render this 1,3-sulfonyl shift stereoselective failed, we uncovered anot

281 An observation of N-to-C 1,3-sulfonyl shift was made when examining these aza-Claisen

282 addition of a keto sulfone and a tandem 1,3-sulfonyl shift/Mannich cyclization to construct the tric

283 lladium catalysis is required, as facile 1,3-sulfonyl shifts dominate under thermal conditions.

284 A glycan microarray library of synthetic 9-N-sulfonyl sialoside analogues was screened to identify po

285 e manner, employing sodium sulfinates as the sulfonyl source and eosin Y as the photocatalyst.

286 substitution on the substrate backbone and N-sulfonyl substituent affect the level of enantioselectiv

287 Epoxidation of N-sulfonyl substituted allenamides with dimethyldioxirane

288 methylphosphonate- and (difluoromethylphenyl)sulfonyl-substituted alkyl acetals.

289 The use of chiral N-sulfonyl-substituted allenamides provided minimal diaste

290 te, whether generated from N-carbamoyl- or N-sulfonyl-substituted allenamides.

291 pyridinium ylides 3, sulfonium ylide 4, and sulfonyl-substituted chloromethyl anion 5.

292 dicate that the twofold deoxygenation of the sulfonyl substrate proceeds by the intervention of an of

293 s and ketone derivatives, thus rendering the sulfonyl triazole traceless.

294 ntioselective oxyamination of alkenes with N-sulfonyl ureas employing chiral, lactic acid-based hyper

295 ficient synthesis of sulfonyl carbamates and sulfonyl ureas from sulfonyl azides employing a palladiu

296 ubstituted amide nucleophiles to afford acyl sulfonyl ureas in good yields.

297 ord a broad range of sulfonyl carbamates and sulfonyl ureas.

298 irecting groups, such as benzyl, ketone, and sulfonyl, were shown to give good enantioselectivity und

299 ed study of amidine synthesis from N-allyl-N-sulfonyl ynamides is described here.

300 With N-sulfonyl ynamides, the use of palladium catalysis is req